Curriculum VitaeGulrana Khuwaja, Ph.D.Assistant Professor

PERSONAL

Father’s Name Hakeem Khalil HusainHome Address: C/O Mr. Jameel Husain, Mohalla. Anta near railway line stop,

Shahjahanpur, U.P, IndiaMobile No. +966559325661Business Address: Neuroscience and Toxicology Unit, Faculty of Pharmacy,

Jazan University, Kingdom of Saudi ArabiaBusiness Phone: +966 559325661Business Fax: +96673217440Email:  gulrana.khuwaja@gmail.com, gulrana_rana@yahoo.co.in,Birth Place: Shahjahanpur, U.P, IndiaCitizenship: IndianPresent position Assistant Professor Faculty of Pharmacy, Jazan University,

Jazan, Kingdom of Saudi Arabia before it Research Associate in the project titled, “Role of some Ayurvedic drugs and herbal extracts in the treatment of cerebral ischemia in rats” in Jamia Hamdard New Delhi 110062.

SKILLSComputer: Working knowledge of Windows, MS Word, Excel, and Internet etc.Languages Knows: English, Hindi and Urdu.

EDUCATION

B.Sc Rohailkhand University, G. F. College Shahjahanpur, UP, India 1995.

M.Sc.

Diplomain computer

Organic Chemistry, Rohailkhand University, G. F. College Shahjahanpur, UP, India 1997.

Working Knowledge, MS Word, Excel and Internet etc Shahjahanpur, UP, India 1998.

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Ph.D. Organic Chemistry, 2006, Department of Chemistry, Aligarh Muslim University, Aligarh, 202002, UP, India.

Title of Ph.D. Thesis: Studies in chemistry of O and N heterocycles and plant products.

ACADEMIC APPOINTMENTS AND POSITIONS

Honors:

1. Best poster presentation Award, held on the “Medical Research day” organized by Faculty of Medicine Jazan University Jazan KSA Saudi Arabia on 1st June 2011.

2. Post Doctor Fellowship in the project entitled, “Role of some Ayurvedic drugs and herbal extracts in the treatment of cerebral ischemia in rats” in Jamia Hamdard New Delhi India, 2010.

3. Research Associate in Jamia Hamdard New Delhi India, 2008.

4. Project fellow under UGC. sponsored research project titled “Synthesis of Pyrazole derivatives and screening them for their potential medicinal use” in the Department of Chemistry A. M. U. Aligarh U.P. India, 2006.

5. Junior project Fellow in the Department of Research in Unani Medicine in the Department of Chemistry A. M. U. Aligarh U.P. India, 2002 sponsored by Tibia College New Delhi.

6. Award Sir Syed Scholarship, in the Department of Chemistry, A. M. U. Aligarh U.P. India, 2001.

PROFESSIONAL SOCIETIES

Life Membership of “Indian Academy of Neurosciences”

FIELD OF SPECIALIZATION:Extraction and purification of active principles from medicinal plants and to check their antioxidant properties using various animal models (Parkinson’s disease, Alzheimer’s disease and cerebral ischemia).

Neurotoxicity biomarker enzymes, Neurotransmitters and their receptors. CNS active drugs, chemicals, brain targeted nanoparticles drugs delivery etc.

Reactive oxygen species and oxidative stress parameters.

Neurodegenerative disorders (Parkinson’s disease, Alzheimer disease, Cerebral Ischemia), their animal management by chemicals, herbal extracts and the active principles.

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Highlights / Experimental Skills:

Expert in the use of Stereotaxic apparatus, spectrophotometer, immunehistochemistry, histopathology, section cutting and staining, electrophoresis (PAGE, Agarose), DNA isolation, & Western blotting.

Extensive experience in the induction of Cerebral Ischemia in rats and mice animal models.

Expert in the induction of Parkinson disease in rats by 6-OHDA model, induction of Alzheimer’s disease in rats model by Streptozotocin model.

Expertise in Neurobehavioral techniques: Morris water maze, Jumping box, Cook’s climbing pole, Video-path analyzer, Rota-rod, Grip test etc.

Expert in handling of animals (Albino Wistar rats and Swiss Albino mice) for the study and Treatment with drugs, ip, iv, im and sc injections, identification and dissection of brain parts.

Professional Experiences:

2010-till date : Assistant Professor Faculty of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia.2006-2010 : 4 years worked on Cerebral Ischemia in rat and mice (MCAO model, Longa et. al. 1989) and Parkinson’s disease in Neurotoxicology Lab, Department of Toxicology, Jamia Hamdard, New Delhi, INDIA.

Worked on the projects related to ischemia and Parkinson disease and their protection by some herbal extracts, active principles and nanocurcumin.

During these projects I had done various enzymatic and non-enzymatic parameters like GPx, GR, GST, SOD, Catalase, GSH, LPO etc., neurobehavioral test like Spontaneous Motor Activity, Flexion test, Rota rod, Grip Test etc., Evans Blue staining, TTC staining, Histopathology and Immunohistochemistry.

Extra Curricular:

1. Recruited as “Head Girl” Sarojini Naidu Hall A.M.U. Aligarh U.P. India, 2003 -2005.

2. Recruited as “House Monitor” Sarojini Naidu Hall A.M.U. Aligarh U.P. India, 2003.

3. Awarded 3rd position in back stroke “Swimming Championship” Aligarh Muslim University Aligarh swimming Club A.M.U. Aligarh U.P. India 2005.

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4. Awarded 2nd position in back stroke “Swimming Championship” Aligarh Muslim University Aligarh swimming Club A.M.U. Aligarh U.P. India 2004.

5. Awarded “3nd position in back stroke Swimming Championship” Aligarh Muslim University Aligarh swimming Club A.M.U. Aligarh U.P. India 2002.

PATENT

Samim M., Maitra A., Naqvi S., Islam F. and Khuwaja G., Patent on the topic “Curcumin encapsulated polymeric micelles and its targeting to brain tissue for the treatment of Brain diseases.” by National Research Development corporation [ A Govt. of India Enterprise] New Delhi (India), Ref.# PAT/4.13.3//10036 July 09 th 2010.

ABSTRACT/PRESENTATIONS

1. Khuwaja G., Safhi MM and Islam F. Safhi, attended, presented and awarded a paper entitled “Neuroprotective effect of Bacopa monniera in 6-hydroxy dopamine model of rats”Medical Research Day at Faculty of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia ,1 June 2011.

2. Khuwaja G., M. Moshahid Khan, Ajmal Ahmad, A. Khan, Syed Shadab Raza, M.B.Khan, P.Srivastav, K.Vaibhav, H. Javed, Fakhrul Islam. Bacopa Monneira protects cerebral Ischemia in rats. International Conference on Advances in Neuroscience, I.A.N, CUSAT, Cochin. Dec. 12-14, 2008.

3. Khuwaja G., Khan MM, Ishrat T, Khan B, Ahmad A, Srivastava P, Khan A, Raza SS, Javed H, Vaibhav K and Islam F. Curcumine protects the oxidative stress induced damage in parkinsonian rats. International Symposium on Advances in Neuroscience and Silver Jubilee Conference of Indian Academy of Neurosciences 2007. Banaras Hindu University, Varanasi-05, India.

4. Khuwaja G, Mohd. Moshahid Khan, Tauheed Ishrat, Badarruzzama Khan, Ajmal Ahmad, Pallavi shrivastava, Andleeb Khan, Syed Shadab Raza, Hayate Javed, Kumar Vaibhav and Fakhrul Islam presented a paper entitle “Curcumine protects the oxidative stress induced damage in parkinsonian rats.”

5. Syed Shadab Raza, Ajmal Ahmad,Khuwaja G., M. Moshahid Khan, M.B. Khan, P.Srivastav, K.Vaibhav, H. Javed, A. Khan, Fakhrul Islam. Sesamin attenuates biochemical, behavioural and histopathological alteration induced by reversible middle cerebral artery occlusion in the rat. International Conference on Advances in Neuroscience, Indian Academy of Neuroscience (I.A.N), CUSAT, Cochin.Dec.12-14, 2008.

6. M. Badruzzaman Khan, H. Javed, A. Ahmad, M. Moshahid Khan, Syed Shadab Raza, Khuwaja G., P.Srivastav, K.Vaibhav, A. Khan, Shazia Jilani, Anand K Deora,

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Fakhrul Islam. Narengenin modulates cognitive deficits caused by the administration of streptozotocin to rats. International Conference on Advances in Neuroscience, I.A.N, CUSAT, Cochin. Dec.12-14, 2008.

7. Hayate Javed, M. Moshahid Khan, Khuwaja G., Syed Shadab Raza, M.B. Khan, Ajmal Ahmad, P.Srivastav, K.Vaibhav, A. Khan, Fakhrul Islam. S-allyl cystein attenuates cognitive performance in streptozotocin induced mice. International Conference on Advances in Neuroscience, I.A.N, CUSAT, Cochin. Dec. 12-14, 2008.

8. Andleeb Khan, Khuwaja G., M.B. Khan, M. Moshahid Khan, Syed Shadab Raza, Ajmal Ahmad, P.Srivastav, K.Vaibhav, H. Javed, Fakhrul Islam. Effect of Thymoquinone on streptozotocin model of cognitive impairment in rats. International Conference on Advances in Neuroscience, I.A.N, CUSAT, Cochin. Dec. 12-14, 2008.

9. Shazia Jilani, Khuwaja G., A. Khan, M. Moshahid Khan, Syed Shadab Raza, H. Javed, Ajmal Ahmad, Anand K. Deora, M.B. Khan, P.Srivastav, K.Vaibhav, Fakhrul Islam. Neuroprotective effect of Withania Somnifera on Cerebral Ischemia in rats. International Conference on Advances in Neuroscience, I.A.N, CUSAT, Cochin. Dec.12-14, 2008.

10. Fakhrul Islam, M.B. Khan, P.Srivastav, K.Vaibhav, Ajmal Ahmad, A. Khan, Mohd. M. Khan, Syed Shadab Raza, H. Javed, Khuwaja G., Ginger extract protects Parkinson’s disease in rats. International Conference on Advances in Neuroscience, I.A.N, CUSAT, Cochin. Dec. 12- 14, 2008.

11. Anand Kanwar Deora, A. Khan, Khuwaja G., Shazia Jilani, M.B. Khan, M. Moshahid Khan, Ajmal Ahmad, , P.Srivastav, K. Vaibhav, Syed Shadab Raza, H. Javed, Fakhrul Islam. Effect of homeopathic medicine on PC12 cell line. International Conference on Advances in Neuroscience, I.A.N, CUSAT, Cochin. Dec’12-14, 2008.

12. Syed Shadab Raza, M. M. Khan, Ajmal Ahmad, Khuwaja G., M. B. Khan, Pallavi Srivastava, Hayate Javed, Kumar Vaibhav, Andleeb Khan and Fakhrul Islam. Protective effect of Silymarin on Transient Focal Cerebral Ischemia in male Wistar rats. Symposium on “Advances in Cerebrovascular Diseases”. 22nd Aug’2008.Central India Institute of Medical Science (CIIMS), Nagpur, India.

13. Fakhrul Islam, Mohd. Moshahid Khan, Khuwaja G., Ajmal Ahmad, Kumar Vaibhav, Syed Shadab Raza. Role of some herbal drugs for the prevention of cerebral Ischemia in rat. Symposium on “Advances in Cerebrovascular Diseases”. 22nd Aug’2008.Central India Institute of Medical Science (CIIMS), Nagpur, India.

14. Mohd.Moshahid Khan, Ajmal Ahmad, Khuwaja G., Syed Shadab Raza, M.B.Khan, Pallavi Srivastava, Hayate Javed, Kumar Vaibhav, Andleeb Khan and Fakhrul Islam. Protective effect of Adenosine on Transient Focal Cerebral Ischemia in male

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wistar rats. Symposium on “Advances in Cerebrovascular Diseases”.22nd Aug’2008.Central India Institute of Medical Science (CIIMS), Nagpur, India.

15. Ajmal Ahmad, Mohd.Moshahid Khan, S. Shadab Raza. M. Badruzzaman, Tauheed Ishrat, Khuwaja G., H. Javed, P. Srivastava, Fakhrul Islam. Neuroprotective property of Querecetin dihydrate in cerebral Ischemia in rats. International Symposium on Advances in Neuroscience and Silver Jubilee Conference of Indian Academy of Neurosciences 2007. Banaras Hindu University, Varanasi-05, India.

16. Mohd. Moshahid Khan, Ajmal Ahmad, Tauheed Ishrat, Khuwaja G., M. B. Khan, Syed Shadab Raza, Hayate Javed, Pallavi Srivastava, Fakhrul Islam. Thymoquinone, a constituent of Nigella sativa, protects dopaminergic neurons against 6-OHDA induced neurotoxicity in Rats. International Symposium on Advances in Neuroscience and Silver Jubilee Conference of Indian Academy of Neurosciences 2007. Banaras Hindu University, Varanasi-05, India.

17. Javed H, Khan MB, Khan MM, Ishrat T, Ahmad A, Khuwaja G., Raza SS, Islam F.Taurine Ameliorates Cognitive Performance in Streptozotocine Model of Rats.Presentation in the International Symposium on Advances in Neurosciences &Silver Jubilee Conferences of Indian Academy of Neurosciences. Theme:Molecular and Cellular basis of brain functions and disorders. BHU, Varanasi India November 22-25, 2007.

Conference and Workshop National and International Attended

1. Attended a Workshop on “Learning-Centered University” Organized by Deanship of Academic Development, Ministry of Higher Education, Jazan University, 8 to 9 October, 2011.

2. Attended Jazan University’s Medical Research Day, 2011 Held at the auditorium, Alshwajra Academic Complex, Complex Jazan University.

3. Attended the UGC-SAP Sponsored “National symposium on Recent Trends in Chemical Sciences” held at the Department of Chemistry, Aligarh Muslim University, Aligarh , 24-25 February 2010.

4. Attended the National symposium on “Epilepsy: Recent advances in drug discovery and treatment” on 13 February, 2010 organized by Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi.

5. Attended and presented poster in the International Conference on “Advances in Neurosciences & XXVI Annual Meeting of Indian Academy Neuroscience” held at Cochin University of Science & Technology, Centre for Neuroscience, Department of Biotechnology, Cochin, India, December 12-14, 2008.

6. Attended and presented poster in the International Conference on Central Indian Institute of medical sciences Silver jubilee Celebration June 2008 to May 2009

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“Advances in Cerebrovascular diseases” as part of Silver jubilee Function of CIIMS, held on 22nd August 2008.

7. Attended and presented poster in the International Symposium on “Advances in Neurosciences & Silver Jubilee Conference of Indian Academy of Neurosciences” (Theme-Molecular and cellular basis of brain functions and disorders) Banaras Hindu University, Varanasi-221005, India, November 22-25, 2007.

8. Attended and presented poster in the CTDDR-2007 “3rd International Symposium on Current Trends in drug discovery research” at Central Drug Research Institute Lucknow, 17th to 21st February, 2007.

9. Attended the International update on “Basic and clinical neurosciences advances and XXIV annual conferences” December 17-20, 2006, in the scientific proceeding at Industrial Toxicology Research centre, Lucknow, India.

10. Attended and presented poster in the International Conference on “Chemistry Biology Interface: Synergistic New Frontier” (CBISNF-2004), Organized by Dr. B.R Ambedkar center for Biomedical Research University of Delhi from November 21-26, 2004.

11. Attended and presented poster in the International Conference on “Recent Advances in biomedical & Therapeutical Sciences” held at Bundelkhand University, Jhansi from 13th to15th January 2004 Jhansi, SUttar Pradesh India.

PUBLICATIONS

1. Raza SS, Khan MM, Ahmad A, Ashafaq M, Khuwaja G, Tabassum R, Javed H, Siddiqui MS, Safhi MM, Islam F. Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke. J Neurolog. Sciences (2011, In Press).

2. Raza SS, Khan MM, Ahmad A, Ashafaq M, Khuwaja G, Tabassum R, Javed H, Siddiqui MS, Safhi MM, Islam F. Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke. Brain Res. 2011, 1420: 93-105.

3. Javed H, Khan MM, Khan A, Vaibhav K, Ahmad A, Khuwaja G, Ahmed ME, Raza SS, Ashafaq M, Tabassum R, Siddiqui MS, El-Agnaf OM, Safhi MM, Islam F.,S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type. Brain Res. 2011, 10:1389:133-42. Epub. 2011 Mar 1.

4. Khuwaja G, Khan MM, Ishrat T, Ahmad A, Raza SS, Ashafaq M, Javed H, Khan MB, Khan A, Vaibhav K, Safhi MM, Islam F. “Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats:’Brain Res. 2011 Jan 12;1368:254-63. Epub 2010 Oct 15.

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5. Ahmad A, Khan MM, Ishrat T, Khan MB, Khuwaja G, Raza SS, Shrivastava P, Islam F “Synergistic effect of selenium and melatonin on neuroprotection in cerebral ischemia in rats.” Biol Trace Elem Res. 2011 Jan; 139(1):81-96. Epub 2010 Apr 1.

6. Khan MM, Hoda MN, Ishrat T, Ahmad A, Khan MB, Khuwaja G, Raza SS, Safhi MM, Islam F.“Amelioration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced behavioural dysfunction and oxidative stress by Pycnogenol in mouse model of Parkinson's disease.”Behav. Pharmacol. 2010 Sep; 21(5-6):563-71.

7. Khan MM, Ahmad A, Ishrat T, Khan MB, Hoda MN, Khuwaja G, Raza SS, Khan A, Javed H, Vaibhav K, Islam F. “Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease.”Brain Res. 2010 Apr 30; 1328:139-51. Epub 2010 Feb 16.

8. Khan MM, Ishrat T, Ahmad A, Hoda MN, Khan MB, Khuwaja G, Srivastava P, Raza SS, Islam F, Ahmad S. “Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats.” Chem. Biol. Interact. 2010 Jan. 5;183 (1):255-63. Epu.

9. Ishrat T, Parveen K, Khan MM, Khuwaja G, Khan MB, Yousuf S, Ahmad A, Shrivastav P, Islam F. Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. Brain Res. 1281:117-27, 2009.

10. Khan MM, Ahmad A, Ishrat T, Khuwaja G, Srivastawa P, Khan MB, Raza SS, Javed H, Vaibhav K, Khan A, Islam F. Rutin protects the neural damage induced by transient focal ischemia in rats. Res. 1292:123-35, 2009.

11. Khan MM, Ishrat T, Ahmad A, Hoda MN, Khan MB, Khuwaja G, Srivastava P, Raza SS, Islam F. Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats. Chem. Biol. Interact. 2009 Oct. 14.

12.Siddiqui Z N, Khuwaja G and Ahmad J. “ Antifungal activity of Cubebin from Piper cubeba”in J. of Indian Chemical Society 84, 823-824, 2007.

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13.Siddiqui Z N, Khuwaja G and Asad M. One Pot Synthesis of 3-acetoacetyl-5-oxo-5H-[1] benzopyrano [3,2-e]pyridin-2-one from triacetic lactones in Indian Journal of Chemistry 45B, 2341, 2006 .

14.Siddiqui Z N, Khuwaja G and Asad M “Synthesis of novel heterocycles from 3-(3-alkyl-5-mercapto-1,2,4-triazolyliminomethyl) chromones” in Heterocyclic Communication 12 (6), 443-448, 2006.

REFERENCES

1. Dr. Fakhrul IslamProfessor Neuroscience and Toxicology Unit, Faculty of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia Email:fislam2001@yahoo.co.in

2. Dr. M. Saeed SiddiquiAssociate ProfessorDepartment of ToxicologyJamia HamdardNew Delhi 110062IndiaTel: +91-11-26059688 Extn. 5569Email: mssiddiqui@jamiahamdard.ac.in

3. Dr. Haider AliAssistant ProfessorDepartment of ToxicologyJamia HamdardNew Delhi 110062IndiaTel: +91-11-26059688 Extn. 5570

Email:hali@jamiahamdard.ac.in

Declaration

I hereby declare that all the statements given above are true to the best of my knowledge. DATE :PLACE: [Dr.Gulrana Khuwaja]

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