1

CURRICULUM VITAE

Personal Details: First Name: Hassan Last Name: Bagher-Ebadian Languages: Farsi, English. Work Address: Room # 79 Section 2F OFP Building, Image Analysis Lab Department of Radiology One Ford Place, Detroit, MI 48202 Tel: (313) 874-4360 Fax: (313) 874-4494

Job Titles: Senior Staff / MR Medical Physicist, Department of Radiology & Research Administration, Henry Ford Hospital, Detroit, MI Appointments: - Department of Physics (Medical Physics), Oakland University, Rochester, MI USA. - Department of Mechanical Engineering, School of Engineering, Shiraz University, Shiraz, Iran. - Department of Nuclear Engineering, Shahid Beheshti University, Tehran, Iran.

Research Interests

I have an interest in a wide range of physiological measurements in the brain and heart using MR Dynamic Contrast Enhanced (DCE), Single Photon Emission Computed Tomography

2

(SPECT) imaging and Positron Emission Tomography (PET) techniques. My recent academic interests are the quantification of cerebral permeability in human and rat models of stroke and cerebral tumor using MRI contrast agents, measurement of cerebral blood flow, transfer rate, blood volume, mean transit time, arterial input function modeling, pharmacokinetic modeling, model averaging, adaptive models and applications of artificial intelligence (AI) in DCE-MRI data analyses. I am also actively working on the outcome prediction of stroke infarction from acute DCE and non-DCE MR information in human using different statistical and analytical modeling. I am familiar with brain lateralization for Epileptic patients as well as Radiotherapy Treatment (RT) planning and shielding. Since 2009, I have been studying MR quantitative biomarkers of drug efficacy for RT and anti-angiogenesis drugs in breast cancer and brain tumor patients. I have technical expertise in applied mathematics and scientific applications programming and have developed, maintained, and documented NeuroPipes, a standard suite of reconstruction, post-processing, and filtering programs for MRI data acquired on different MR consoles/machines (7T and 3T).

Academic Qualification:

2007- 2010 Ph.D.

Biomedical Sciences, Medical Physics Department of Physics, Oakland University, Rochester, MI Dissertation Title: Application of Adaptive Models in MRI

1993 - 1996 MSc.

Nuclear Engineering (Application in Medicine) Department of Nuclear Engineering, Amir-Kabir University of Technology, Tehran, Iran Thesis Title: Extraction of Anatomical Features from Medical Images Using Neural Network Approach.

1988 - 1993 BSc.

Bachelor of Science- Applied Physics (Solid State) Department of Physics, Isfahan University of Technology, Isfahan, Iran Thesis Title: Simulation and modeling of the phase state for type-I and II super conductive materials placed in a high frequency external alternative magnetic field.

Positions and Employment 2001 – 2006 Senior Research Associate in Stroke Program Project at the Neurology Department of Henry Ford Hospital, Detroit, MI USA 2006 – 2010 Research Scientist-I /Academic Instructor of the Neurology Department at Henry Ford Hospital, Detroit, MI USA

2010 – 2013 MR Medical Physicist – Assistant Professor, Research Scientist Level-II with the department of Neurology at Henry Ford Hospital, Detroit, MI USA

2013 – Present Senior Staff, MR Medical Physicist with the department of Radiology at Henry Ford Hospital, Detroit, MI USA

3

Honors and Memberships

2002-Present Ad-hoc Reviewer of the IEEE Trans. On Biomedical Engineering Journal, Washington, D.C. 2005-Present Senior Member of Sigma Xi, the Scientific Research Society, NC 27709, USA. 2005 – Present Permanent member of the technical committee and reviewers of the International Conference on Image Processing associated with the IEEE Transaction on Medical Imaging, Atlanta, USA. 2006-Present Member of the International Society of Magnetic Resonance In Medicine (ISMRM). 2007 Evaluated and recognized as an outstanding researcher and granted US residency by the department of U.S. Citizenship and Immigration Services (USCIS), Nebraska, Lincoln NE 68501 USA. 2007-Present Member of the Nuclear Medicine Society. 2008-Present Ad-hoc Reviewer of Magnetic Resonance in Medicine journal. 2008-Present Ad-hoc Reviewer of Journal of Magnetic Resonance Imaging (JMRI) journal. 2008- Present Member of the Society of Molecular Imaging. 2009-Present Member of the International Neural Network Society

2009-Present Member of the American Association for the Advancement of Science (AAAS) 2010 Recognized and listed in the record of Montclair Who’s Who as an outstanding biomedical expert and awarded the Montclair Who’s Who certificate and honored membership. 2013 Recipient of NIH/NINDS award for “Curing the Epilepsies 2013: Pathways Forward”, NIH, Bethesda, USA

Selected Peer-Reviewed Journal Publications

Hosseini-Ashrafi ME, Bagher-Ebadian H, Yahaghi E. Pre-Optimization of radiotherapy treatment planning: an artificial neural network classification aided technique. Journal of Phys Med Biol 1999;(6):Vol. 44:1513-1528. PMID:10498520

4

Mitsias P, Ewing JR, Patel SC, Khalighi M, Bagher-Ebadian H, Zhao Q, Santhakumar S, Soltanian –Zadeh H, Lu M, Chopp M. Predicting Tissue Outcome in Acute Human Cerebral P8 Ischemia with Multiparametric Magnetic Resonance Imaging. J Stroke, 2003(44), 2 (44); 20-22. Bagher-Ebadian H, Soltanian –Zadeh H, Setayeshi S, Smith ST. Neural Network and Fuzzy Clustering Approach for Automatic Diagnosis of Coronary Artery Disease in Nuclear Medicine. Journals of IEEE Transaction on Nuclear Science 2004;(51)1:184-192. Mitsias, PD, JR Ewing, M Lu, MM Khalighi, M Pasnoor, H. Bagher- Ebadian, Q Zhao, S Santhakumar, MA Jacobs, H Soltanian-Zadeh, SC Patel, M Chopp. Assessing Tissue Viability in Acute Human Cerebral Ischemia with Multiparametric ISODATA Magnetic Resonance Imaging. American J Neuroadiol 2004;25:1499–1508. PMID:15502128 Mitsias PD, M Lu, D Morris, B Silver, C Lewandowski, NI Papamitsakis, MM Khaligi, H. Bagher- Ebadian, Q Zhao, H Soltanian-Zadeh, S Daley, D Hearshen, JR Ewing, SC Patel, M Chopp. Treatment of Acute Supratentorial Ischemic Stroke With Abciximab is Safe and May Result in Early Neurological Improvement. A Preliminary Report. J Cereb Dis 2004;(18):(3)249-250. PMID:15305070 Mitsias PD, Ewing JR, Lu M, Khalighi MM, Pasnoor M, Bagher-Ebadian H, Zhao Q, Santhakumar S, Jacobs MA, Papamitsakis N, Soltanian-Zadeh H, Hearshen DO, Patel SC, Chopp M. Multiparametric Iterative Self-Organizing MR Imaging Data Analysis Technique for Assessment of Tissue Viability in Acute Cerebral Ischemia. American J Neuroadiol 2004;(25):1499-1508. PMID:15502128 Lu M, Mitsias PD, Ewing JR, Soltanian-Zadeh H, Bagher-Ebadian H, Zhao Q, Tebbe NO, Patel SC, Chopp M. Predicting Final Infarct Size Using Acute and Subacute Multiparametric MRI Measurements in Patients with Ischemic Stroke. J Magn Reson Imaging 2005;21(5):495-502. PMID:15834917 Mitsias PD, Lu M, Silver B, Morris D, Ewing JR, Daley S, Lewandowski C, Katramados A, Papamitsakis NI, Khaligi MH, Ebadian HB, Zhao Q, Soltanian-Zadeh H, Hearshen D, Patel S, Chopp M. MRI-Guided, Open Trial of Abciximab for Ischemic Stroke Within a 3 to 24 Hour Window. Neurology 2005;65(4):612-615. PMID:16116128 Jiang Q, Zhang ZG, Ding GL, Silver B, Zhang L, Meng H, Lu M, Pourabdillah-Nejed-D S, Wang L, Savant- Bhonsale S, Li L, Bagher-Ebadian H, Hu J, Arbab AS, Vanguri P, Ewing JR, Ledbetter KA, Chopp M.. MRI Detects White Matter Reorganization After Neural Progenitor Cell Treatment of Stroke. Neuroimage 2006; 32(3):1080-9. PMID:16860575 Soltanian-Zadeh H, Bagher-Ebadian H, Ewing JR, Mitsias PD, Kapke A, Lu M, Jiang Q, Patel SC, Chopp M. Multi-Parametric Iterative Self-Organizing Data Analysis of Ischemic Lesions Using Pre- or Post-Gd T1 MRI. J Cereb Dis 2006;(23):91-102. PMID:17124388 Bagher-Ebadian H, Nagaraja TN, Paudyal R, Whitton P, Panda S, Fenstermacher JD, Ewing JR. MRI Estimation of Contrast Agent Concentration in Tissue Using an Artificial Neural Network. J Magn Reson Med 2007;58(2):290-297. PMID:17654573

5

Bagher-Ebadian H, Jiang Q, Ewing JR. A Modified Fourier-Based Phase Unwrapping Algorithm With an Application to MRI Venography. J Magn Reson Imaging 2008;27(3):649-52. PMC2575666 Sheim S, Bagher-Ebadian H, Panda S, Nelsen K, Brown S, Chetty I, Ewing JR, Mikkelsen T, MRI Measures of Vascular Parameters Predict Treatment Response to Radiation and Anti-angiogenic Agents in Rat Brain Tumors, Int. J of Rad Onc. Bio. Phys., 2008: 72 (1): 82-83 Ewing JR, Brown SL, Nagaraja TN, Bagher-Ebadian H, Paudyal R, Panda S, Knight R, Ding G, Jiang Q, Lu M, Fenstermacher JD. MRI Measurement of Change in Vascular Parameters in the 9L Rat Cerebral Tumor After Dexamethasone Administration, Journal of Magnetic Resonance Imaging. 2008; 27(6):1430-1438. PMC2575657 Bagher-Ebadian H, Soltanian-Zadeh H, Setayeshi S, Re-orientation of the left ventricle’s long-axis cardiac SPECT images using a statistical recursive method, J Nucl Med. 2008; 49 (1):406-407. Bagher-Ebadian H, Soltanian-Zadeh H, Setayeshi S, A hierarchical fuzzy clustering model for myocardial segmentation in cardiac SPECT images, J Nucl Med. 2008; 49(1):124-125. Bagher-Ebadian H, Jafari-Khouzani K, Mitsias PD, Soltanian-Zadeh H, Chopp M, Ewing JR, Prdicting Final Extent of Ischemic Infarction Using Artificial Neural Network Analysis of Multiparametric MRI in Patients With Stroke., IEEE-IJCNN, 2009: 3 (4): 229-235. PMC 978-1-4244-3553-1 Bagher-Ebadian H, Ewing JR, A model to explore the ability of SPECT imaging for diagnosis of coronary artery disease, J Nucl Med. 2009;50 (2):1456-1457. Bagher-Ebadian H, Paudyal R, Mikkelsen T, Jiang Q, Ewing JR, Rapid and Direct Quantification of Longitudinal Relaxation Time (T1) in Look-Locker Sequences Using an Adaptive Neural Network, , IEEE-IJCNN, 2009: 3 (4): 236-241. PMC 978-1-4244-3553-1 Bagher-Ebadian H, Paudyal R, Nagaraja TN, Croxen R, Fenstermacher JD, Ewing JR, MRI Estimation of Gadolinium and Albumin Effects on Water-Proton, Journal of Neuroimage, 18 May 2010, REF: 20493266. Bagher-Ebadian H, Rajan J, Narang J, Generalized linear model approach for diagnosis of coronary artery disease in nuclear medicine, J Nucl Med. 2010;82 (1), REF:798963. Bagher-Ebadian H, Soltanian-Zadeh H, Analytical method for cardiac SPECT simulation, J Nucl Med. 2010;1328 (1), REF:798483. Bagher-Ebadian H, Jafari-Khouzani K, Quantitative study of kidney perfusion: Using an analytical model of blood circulatory system, J Nucl Med. 2010;1329 (1), REF: 798509. Mitsias PD, Lu M, Silver B, Morris D, Ewing JR, Daley S, Lewandowski C, Katramados A, Papamitsakis NI, Khaligi MH, Ebadian HB, Zhao Q, Soltanian-Zadeh H, Hearshen D, Patel S, Chopp M. MRI-Guided, Open Trial of Abciximab for Ischemic Stroke Within a 3 to 24 Hour Window. Neurology 2005;65(4):612-615. PMID:16116128

6

Jiang Q, Zhang ZG, Ding GL, Silver B, Zhang L, Meng H, Lu M, Pourabdillah-Nejed-D S, Wang L, Savant- Bhonsale S, Li L, Bagher-Ebadian H, Hu J, Arbab AS, Vanguri P, Ewing JR, Ledbetter KA, Chopp M.. MRI Detects White Matter Reorganization After Neural Progenitor Cell Treatment of Stroke. Neuroimage 2006; 32(3):1080-9. PMID:16860575 Soltanian-Zadeh H, Bagher-Ebadian H, Ewing JR, Mitsias PD, Kapke A, Lu M, Jiang Q, Patel SC, Chopp M. Multi-Parametric Iterative Self-Organizing Data Analysis of Ischemic Lesions Using Pre- or Post-Gd T1 MRI. J Cereb Dis 2006;(23):91-102. PMID:17124388 Bagher-Ebadian H, Paudyal R, Nagaraja TN, Croxen R, Fenstermacher JD, Ewing JR, MRI Estimation of Gadolinium and Albumin Effects on Water-Proton, Journal of Neuroimage, 18 May 2010, REF: 20493266. Paudyal R, Ewing JR, Nagaraja TN, Bagher-Ebadian H, Knight RA, Panda S, Lu M, Ledbetter K, Fenstermacher JD. The concordance of MRI and quantitative autoradiography estimates of the transvascular transfer rate constant of albumin in a rat brain tumor model. Magn Reson Med. 0740-3194, May 31, 2011,.PMID 21630343 Bagher-Ebadian H, Nejad-Davarani SP, Ali MM, Brown S, Makki M, Jiang Q, Noll DC, and Ewing JR, Magnetic Resonance Imaging Estimation of Longitudinal Relaxation Rate Change (ΔR1) in Dual Gradient Echo Sequences Using an Adaptive Model, IEEE-IJCNN, 2011: 515 (140): 2501-2506. PMC 978-1-4244-9636-5. Bagher-Ebadian H, Jain R, Paudyal R, Nejad-Davarani SP, Narang J, Jiang Q, Mikkelsen T, and Ewing JR, Magnetic Resonance Estimation of Longitudinal Relaxation Time (T1) in Spoiled Gradient Echo Using an Adaptive Neural Network, IEEE-IJCNN, 2011: 523 (73): 2557-2562. PMC 978-1-4244-9636-5. Bagher-Ebadian H, Nassiry C, Ranjbar Z, Faghihi R, Diagnosis of coronary artery disease in nuclear medicine using generalized linear model and singular value decomposition, J Nucl Med. 2011; 52 (Supplement 1):2038. Bagher-Ebadian H, Jafari-Khouzani K, Mitsias PD, Lu M, Soltanian-Zadeh H, et al. (2011) Predicting Final Extent of Ischemic Infarction Using Artificial Neural Network Analysis of Multi-Parametric MRI in Patients with Stroke. PLoS ONE 6(8): e22626. doi:10.1371/journal.pone.0022626 Paudyal R, Bagher-Ebadian H, Nagaraja TN, Fenstermacher JD, Ewing JR. Modeling of Look-Locker estimates of the magnetic resonance imaging estimate of longitudinal relaxation rate in tissue after contrast administration. Magn Reson Med. May 31, 2011.PMID 21630341. Bagher-Ebadian H, Jain R, Nejad-Davarani SP, Mikkelsen T, Lu M, Jiang Q, Scarpace L, Arbab AS, Narang J, Soltanian-Zadeh H, Paudyal R, Ewing JR, Model Selection for DCE-T1 Studies in Glioblastoma, Magn Reson Med. published online: 29 NOV 2011 DOI: 10.1002/mrm.23211. Jain R, Brent G, Narang J, Mikkelsen Tom, Bagher-Ebadian H, Nejad-Davarani SP, Ewing JR, Arbab AS, Content loaded within last 14 days Blood-Brain-Barrier Imaging in Brain Tumors: Concepts and Methods, Journal of Neurographics, Vol.2, Number 2, June 2012 , pp. 48-59(12).

7

Jain R, Narang J, Brent G, Bagher-Ebadian H, Scarpace L, Mikkelsen T, Littenberg B, Schultz LR, Prognostic vascular imaging biomarkers in high-grade gliomas: Tumor permeability as an adjunct to blood volume estimates, Neuro Oncol (2013) 15 (1): 1-3 Asm Iskander, Robert A Knight, Zheng Gang Zhang, James R Ewing, Adarsh Shankar, Nadimpalli Ravi S Varma, Hassan Bagher-Ebadian, Meser M Ali, Ali S Arbab, Branislava Janic, Intravenous Administration of Human Umbilical Cord Blood-Derived AC133+ Endothelial Progenitor Cells in Rat Stroke Model Reduces Infarct Volume: Magnetic Resonance Imaging and Histological Findings, Journal of Stem cells translational medicine 2 (9), 703-714, 2013.

Ewing JR, Bagher‐Ebadian H, Model selection in measures of vascular parameters using dynamic contrast‐enhanced MRI: experimental and clinical applications, Journal of NMR in Biomedicine 26 (8), 1028-1041, 2013.

Aryal MP, Nagaraja TN, Keenan KA, Bagher‐Ebadian H, Panda S, Brown SL, Cabral G, Fenstermacher JD, Ewing JR, Dynamic contrast enhanced MRI parameters and tumor cellularity in a rat model of cerebral glioma at 7 T, Magn Reson Med, Article first published online: 22 JUL 2013, DOI: 10.1002/mrm.24873 Fozouni N, Chopp M, Nejad-Davarani SP, Zhang ZG, Lehman NL, Gu S, Ueno Y, Lu M, Ding G, Li L, Hu J, Bagher-Ebadian H, Hearshen D, Jiang Q, Characterizing Brain Structures and Remodeling after TBI Based on Information Content, Diffusion Entropy, PLoS one, 8 (10): e76343, 2013 Ali MM, Kumar S, Shankar A, Varma NRS, Iskander AMS, Janic B, Chwang WB, Jain R, Babajeni-Feremi A, Borin TF, Bagher-Ebadian H, Brown SL, Ewing JR, Arbab AS, Effects of Tyrosine Kinase Inhibitors and CXCR4 Antagonist on Tumor Growth and Angiogenesis in Rat Glioma Model: MRI and Protein Analysis Study, Journal of Translational oncology, 6 (6) pp: 660-666, 2013 Nagaraja TN, Aryal MP, Brown SL, Bagher-Ebadian H, Mikkelsen T, Yang JJ, Panda S, Keenan KA, Cabral G, Ewing JR, Cilengitide-Induced Temporal Variations in Transvascular Transfer Parameters of Tumor Vasculature in a Rat Glioma Model: Identifying Potential MRI Biomarkers of Acute Effects, PLoS one, 8(12): e84493, 2013

Chwang WB, Jain R, Bagher‐Ebadian H, Nejad‐Davarani SP, Iskander A, VanSlooten A, Schultz L, Arbab AS, Ewing JR, Measurement of Rat Brain Tumor Kinetics Using an

Intravascular MR Contrast Agent and DCE‐MRI Nested Model Selection, Journal of Magnetic Resonance Imaging, 13 JAN 2014 DOI: 10.1002/jmri.24469. Nazem-Zadeh MR, Schwalb MJ, Elisevich KV, Bagher-Ebadian H, Hamidian H, Akhondi-Asl AR, Jafari-Khouzani K, Soltanian-Zadeh H, Lateralization of Temporal Lobe Epilepsy using a Novel Uncertainty Analysis of MR Diffusion in Hippocampus, Cingulum, and Fornix, and Hippocampal Volume and FLAIR Intensity, Journal of the Neurological Sciences, Available Online (in press) May 6-2014.

Peer-Reviewed Journal Publications in Press/Submitted

1. Bagher-Ebadian H, Nejad-Davarani SP, Jain R, Mikkelsen T, Lu M, Jiang Q, Jayant N, Scarpace L, Arbab SA, Ewing JR, Comparison of Signal Intensity and Standard Techniques for Estimation of Pharmacokinetic Parameters in DCE-T1 Studies of Glioblastoma: Using Model Selection, Magn Reson Med. submitted in March. 2014.

8

2. Bagher-Ebadian H, Paudyal R, Nejad-Davarani SP, Jiang Q, Scarpace L, Asgari MH,

Mikkelsen T, Ewing JR, Fensemacher JD,and Ewing JR, MR Estimation of Longitudinal Relaxation Time (T1) in Spoiled Gradient Echo Using an Adaptive Neural Network, Submitted to the Journal of MRM, May. 2013.

3. Bagher-Ebadian H, Noorizadeh A, Nejad-Davarani SP, Knight R, Nagaraja T, Paudyal R, Brown S, Panda S and Ewing JR, MR Estimation of Arterial Input Function (AIF) in Dual Gradient Echo Sequences Using an Adaptive Model Trained by Standard Radiological AIF, Submitted to MRM, Nov. 2013.

Selected Peer-Reviewed Conference Publications

Bagher-Ebadian H, Setayeshi S, Soltanian-Zadeh H,Neural network approach to diagnos of coronary artery disease in nuclear medicine, Institute for Studies in Theoretical Physics and Mathematics (IPM), 11(2): 27, May 22th, Tehran, Iran (2002). Soltanian-Zadeh H, Mitsias PD, Khalighi MM, Lu M, Bagher-Ebadian H, Ewing JR, Zhao Q, Patel SC, Chopp M, Relationships among ISODATA, DWI, MTT, and T2 Lesions in Stroke, Intl. Soc. Mag. Reson. Med.11 (2003), 2245, Toronto, Canada. Nagesh V, Mikkelsen T, Churchman J, Nelson K, Bagher-Ebadian H, Whitton P, Ewing JR, Quantitative T1s at : A Tool for Diagnosis and Characterizat ion of Spheroid Tumors and Detection of Blood-Brain Barrier Leakage Regions, Intl. Soc. Mag. Reson. Med.13 (2005), 395, Miami, Florida, USA. Bagher-Ebadian H, Paudyal, Ewing JR, MRI Estimation of Gd-DTPA Concentration in Tissue from TOMROP Sequence Using Neural Network Approach, 2th Annual Symposium Medical Imaging – HFH, (2005) Detroit, USA, April-2005, 78(2). Ewing JR, Bagher-Ebadian H, Paudyal R,The Ratio of T2* and T1 Relaxivities in Experimental Cerebral Tumor and Normal Brain, Intl. Soc. Mag. Reson. Med.14 (2006), 1494, Seattle, USA. Bagher-Ebadian H, Ewing JR, Jiang Q, Application of Fourier-Based Phase Unwrapping Algorithm for MR-Venography, Intl. Soc. Mag. Reson. Med.14 (2006), 1921, Seattle, USA. Bagher-Ebadian H, Haacke EM, Jiang Q, Ewing JR, A Modified Fourier Based Phase Unwrapping Algorithm with an Application to MR Venography, 3th Annual Symposium Medical Imaging – HFH, (2006) Detroit, USA, March-2006, 85(3). Ewing JR, Brown S, Bagher-Ebadian H, Churchman J, Panda S, Paudyal R, Fenstermacher J, MRI Measures of Changes in the Transfer Constant of Gadomer after Dexamethasone in 9L rat Cerebral Tumor, International Conference on Physc. & Med., Suppl. 18, (1);13-17, London, UK 2006. Jiang Q, Zhang Q, Ding G, Silver B, Meng H, Pourabdollah S, Wang L, Li L, Bagher-Ebadian H, Hu J, Arbab AS, Ewing JR, Chopp M, MRI Detection of White Matter Remodeling after Neural Progenitor Cell Treatment of Stroke, Intl. Soc. Mag. Reson. Med.14 (2006), 623, Seattle, USA.

9

Bagher-Ebadian H, Nagaraja TN, Paudyal, Whitton P, R, Panda S, Karyn L, Fenstemarcher JD, Ewing JR, MRI Estimation of Contrast Agent Concentration in Tissue Using a Neural Network Approach, Intl. Soc. Mag. Reson. Med.15 (2007), Berlin, Germany. Jiang Q, Alexander DC, Ding GL, Zhang ZG, Pourabdollah Nejad S, Zhang L, Bagher-Ebadian H, Ewing JR, Chopp M., White Matter Reorganization after Stroke Measured by Gaussian DTI, q-ball, and PAS MRI, Intl. Soc. Mag. Reson. Med.15 (2007), 134, Berlin, Germany. Pourabdollah S, Bagherebadian H, Jiang Q, Noll DC, Alexander DC, Ewing JR, Jafari-Khouzani K, Chopp M, White Matter and Ischemia Visualization in MR Images for Stroke Patients Using Independent Component Analysis, Intl. Soc. Mag. Reson. Med.15 (2007), 154, Berlin, Germany. Bagher-Ebadian H, Soltanian-Zadeh H, Setayeshi S, Analytical Method for Cardiac SPECT Simulation, 4th Annual Symposium Medical Imaging – HFH, (2007) Detroit, USA, April-2007, 34(3). Bagher-Ebadian H, Ewing JR, Soltanian-Zadeh H, Mitsias PD, Jafari-Khouzani K, Chopp M, Predicting MRI 3-Month Infarct in Patients with Ischemic Stroke Using an Artificial Neural Network Technique, Intl. Soc. Mag. Reson. Med.15 (2007), Berlin, Germany. Bagher-Ebadian H, Jafari-Khouzani K, Mitsias PD, Chopp M, Ewing JR, MRI Measurement of Ischemic Brain Penumbra Using Kohonen’s Multi-Parametric Self-Organizing Map (KMP-SOM) Technique, Proc. Intl. Soc. Mag. Reson. Med.16 (2008), Toronto, Canada. Bagher-Ebadian H, Jafari-Khouzani K, Soltanian-Zadeh H, Ewing JR,A Blood Circulatory Model to Estimate the Arterial Input Function in MR Brain Perfusion Studies, Proc. Intl. Soc. Mag. Reson. Med.16 (2008), Toronto, Canada. Bagher-Ebadian H, Jafari-Khouzani K, Soltanian-Zadeh H, Ewing JR, Blood Circulatory Model to Estimate Arterial Input Function in Brain MR Perfusion Study, 5th Annual Symposium Medical Imaging – HFH, (2008) Detroit, USA, April-2008, 72(5). Jiang Q, Gollapalli L, Haack ME, Ding GL, Zhang ZG, Zhang L, Li L, Wang Y, Ewing JR, Hu JN, Bagher-Ebadian H, Chopp M, Susceptibility Weighted MRI for Detection and Staging of Angiogenesis After Stroke in Rats, Intl. Soc. Mag. Reson. Med. 16 (2008) 304, Toronto, Canada. Ewing JR, Nagaraja TN, Paudyal R, Bagher-Ebadian H, Robert K, Karyn L, Fenstemarcher JD, An MRI Estimate of Vascular Permeability in 9L Cerebral Tumor Agrees with Those of Quantitative Autoradiography, Proc. Intl. Soc. Mag. Reson. Med.16 (2008), Toronto, Canada. Paudyal R, Bagher-Ebadian H, Nagaraja TN, Fenstemarcher JD, Ewing JR, MRI Look Locker Estimates of the Longitudinal Relaxation Rate Are Approximately Linear in Contrast Agent Tissue Concentration, Proc. Intl. Soc. Mag. Reson. Med.16 (2008), Toronto, Canada.

10

Bagher-Ebadian H, Jafari-Khouzani K, Soltanian-Zadeh H, Ewing JR, A Blood Circulatory Model to Estimate the Arterial Input Function in MR Brain Perfusion Studies, Soc. Mag. Reson. Med. 16 (2008) 3260, Toronto, Canada. Ewing JR, Nagaraja TN, Paudya R, Bagher-Ebadian H, Robert K, Karyn L, Fenstermacher JD, An MRI Estimate of Vascular Permeability in 9L Cerebral Tumor Agrees with Those of Quantitative Autoradiography, Intl. Soc. Mag. Reson. Med. 16 (2008) 1886, Toronto, Canada. Paudya R, Bagher-Ebadian H, Nagaraja TN, Fenstermacher JD, Ewing JR, MRI Look Locker Estimates of the Longitudinal Relaxation Rate Are Approximately Linear in Contrast Agent Tissue Concentration, Intl. Soc. Mag. Reson. Med. 16 (2008) 2305, Toronto, Canada. Bagher-Ebadian H, Jafari-Khouzani K, Mitsias PD, Chopp M, Ewing JR, MRI Measurement of Ischemic Brain Penumbra Using Kohonen’s Multi-Parametric Self-Organizing Map (KMP-SOM) Technique, Intl. Soc. Mag. Reson. Med. 16 (2008) 557, Toronto, Canada. Bagher-Ebadian H, Paudyal R, Mikkelsen T, Jiang T, Ewing JR, Rapid and Direct Quantification of Longitudinal Relaxation Time (T1) in Look-Locker Sequences Using an Adaptive Neural Network, Proc. Intl. Soc. Mag. Reson. Med. 17 (2009) 1482, Honolulu, Hawaii. Paudyal R, Bagher-Ebadian H, Nagaraja T, Panda S, Fenstermacher JD, Ewing JR, The Effects Equilibrium Intercompartmental Water Exchange Kinetics on MRI Estimation of Tissue Concentration of Contrast Agents, Proc. Intl. Soc. Mag. Reson. Med. 17 (2009) 721, Honolulu, Hawaii. Bagher-Ebadian H, Paudyal R, Ewing JR, Analytical Equation of State for Rapid and Direct Quantification of Longitudinal Relaxation Time (T1) in Look-Locker Sequences, Proc. Intl. Soc. Mag. Reson. Med. 17 (2009) 3609, Honolulu, Hawaii. Jiang Q, Ding GL, Pourabdollah-Nejad S, Qu CS, Mahmood A, Li L, Zhang ZG, Hu JN, Shen YN, Kou ZF, Bagher-Ebadian H, Ewing JR, Chopp M, Neural Progenitor Cell Distribution and White Matter Reorganization after Traumatic Brain Injury Measured by MRI and Histology, Intl. Soc. Mag. Reson. Med. 17 (2009) 1161, Honolulu, Hawaii. Bagher-Ebadian H, Jafari-Khouzani K, Mitsias PD, Soltanian-Zadeh H, Chopp M, Ewing JR, Prdicting Final Extent of Ischemic Infarction Using Artificial Neural Network Analysis of Multiparametric MRI in Patients With Stroke. Proceedings of International Joint Conference on Neural Networks, IEEE-IJCNN (2009), International Joint Conference on Neural Network, Atlanta 14-17 June, 2009-3 (4): 229-235. Bagher-Ebadian H, Paudyal R, Mikkelsen T, Jiang Q, Ewing JR, Rapid and Direct Quantification of Longitudinal Relaxation Time (T1) in Look-Locker Sequences Using an Adaptive Neural Network: Proceedings of International Joint Conference on Neural Networks, IEEE-IJCNN ( 2009), International Joint Conference on Neural Network, Atlanta 14-17 June, 2009: 3 (4): 236-241. Bagher-Ebadian H, Paudyal R, Nagaraja TN, Croxen RL, Fenstermacher JD, Ewing JR, MRI Estimation of Gadolinium and Albumin Effects on Water-Proton, International Brain Mapping & Intraoperative Surgical Planning Society (IBMISPS) 2009, Harvard Medical School, OA, 1(O3) 03, Boston, USA.

11

Nassiry CH, Bagher-Ebadian H, Faghihi R, Paudyal R, MR Estimation of Longitudinal Relaxation Time (T1) in Rat Brain Using Gauss-Newton Method, International Brain Mapping & Intraoperative Surgical Planning Society (IBMISPS) 2009, Harvard Medical School, OP1 (01), Boston, USA. Entezarmahdi M, Bagher-Ebadian H, Faghihi R, Mitsias P, Asgari MH, Chopp M, and Ewing JR, MR Morphological Features Analysis for Predicting Final Extent of Ischemic Infarction in Patients with Stroke, International Brain Mapping & Intraoperative Surgical Planning Society (IBMISPS) 2010, Salt Lake City, OP1 (01), Utah, USA. Nejad-Davarani SP, and Bagher-Ebadian H, Vasculature Model for Direct Estimation of Hemodynamic Maps in MR Brain Perfusion, International Brain Mapping & Intraoperative Surgical Planning Society (IBMISPS) 2010, Salt Lake City, OP1 (01), Utah, USA. Entezarmahdi M, Bagher-Ebadian H, Faghihi R, Mitsias P, Asgari MH, Chopp M, and Ewing JR, MR Morphological Features Analysis for Predicting Final Extent of Ischemic Infarction in Patients with Stroke, 7th Annual Symposium Medical Imaging – HFH, (2010) Detroit, USA, May-2010, 72(5). Nejad-Davarani SP, Quan J, Bagher-Ebadian H, Bowyer SM, Seidman MD, and Chopp M, Application of Resting State fMRI for Studying Neural Connectivity in Tinnitus Patients, 7th Annual Symposium Medical Imaging – HFH, (2010) Detroit, USA, May-2010, 72(5). Bagher-Ebadian H, Mitsias PD, Asgari MH, Chopp M, Ewing JR, MRI Measurement of Ischemic Brain Penumbra Using an Inelastic Collision Model, Intl. Soc. Mag. Reson. Med. 18 (2010) 674, Stockholm, Sweden Bagher-Ebadian H, Paudyal R, Jain R, Narang J, Ewing JR, Optimal Flip Angle Set in Spoiled Gradient-Echo MR Imaging Technique, Intl. Soc. Mag. Reson. Med. 18 (2010), 7108, E-79, 62, Stockholm, Sweden Bagher-Ebadian H, Narang J, Ewing JR, Davarani-Nejad SP, Asgari MH, Saksena S, Jain R, Direct Comparison of Dynamic Susceptibility Weighted MR Perfusion with CT Perfusion in Brain Tumors, Intl. Soc. Mag. Reson. Med. 18 (2010), 5238, E-80, 63, Stockholm, Sweden Noorizadeh A, Bagher-Ebadian H, Faghihi R, Narang J, Jain R, Ewing JR, Input Function Detection in MR Brain Perfusion Using a Blood Circulatory Model Based Algorithm, Intl. Soc. Mag. Reson. Med. 18 (2010), 6775, E-104, 125, Stockholm, Sweden Jain R, Bagher-Ebadian H, Narang J, Davarani-Nejad SP, Sakesna S, Schultz L, Asgari MH, Ewing JR, Optimal Period of Linearity Using Patlak Analysis in Brain Tumors, Intl. Soc. Mag. Reson. Med. 18 (2010), 5380, E-79, 62, Stockholm, Sweden Paudyal R, Bagher-Ebadian H, Panda S, Fenstemacher JD, Ewing JR, MRI T2

* and T1 Ratio for Assessment of Transport of Macromolecular Contrast Agent in Tumor Interstitium, Intl. Soc. Mag. Reson. Med. 18 (2010), 3853, T-47, Stockholm, Sweden. Bagher-Ebadian H, Nejad-Davarani SP, Ali MM, Brown S, Makki M, Jiang Q, Noll DC, and Ewing JR, Magnetic Resonance Imaging Estimation of Longitudinal Relaxation Rate Change (ΔR1) in Dual Gradient Echo Sequences Using an Adaptive Model, IEEE-IJCNN, 2011: 515 (140): 2501-2506. PMC 978-1-4244-9636-5.

12

Bagher-Ebadian H, Jain R, Paudyal R, Nejad-Davarani SP, Narang J, Jiang Q, Mikkelsen T, and Ewing JR, Magnetic Resonance Estimation of Longitudinal Relaxation Time (T1) in Spoiled Gradient Echo Using an Adaptive Neural Network, IEEE-IJCNN, 2011: 523 (73): 2557-2562. PMC 978-1-4244-9636-5. Bagher-Ebadian H, Nejad-Davarani SP, Paudyal R, Nagaraga TN, Brown S, Knight R, Fenstermacher JD and Ewing JR, Construction of a Model-Based High Resolution Arterial Input Function (AIF) Using a Standard Radiological AIF and the Levenberg-Marquardt Algorithm, Intl. Soc. Mag. Reson. Med. 19 (2011) 3902, Montreal, Canada. Bagher-Ebadian H, Nagaraga TN, Paudyal R, Brown S, Knight R, Panda S, Whitton P, Fenstermacher JD and Ewing JR, MR Estimation of Arterial Input Function (AIF) in Dual Gradient Echo Sequences Using an Adaptive Model Trained by Standard Radiological AIF, Intl. Soc. Mag. Reson. Med. 19 (2011) 3900, Montreal, Canada. Bagher-Ebadian H, Ali MM, Arbab AS, Makki M, Nejad-Davarani SP, Panda S, Jiang Q, and Ewing JR, Adaptive Neural Network for Direct Quantification of Longitudinal Relaxation Rate Change (ΔR1) in T One by Multiple Read Out (TOMROP) Sequence, Intl. Soc. Mag. Reson. Med. 19 (2011) 3907, Montreal, Canada. Bagher-Ebadian H, Nejad-Davarani SP, Paudyal R, Mikkelsen T, Jiang Q, and Ewing JR, MR Estimation of Longitudinal Relaxation Time (T1) in Spoiled Gradient Echo Using an Adaptive Neural Network, Intl. Soc. Mag. Reson. Med. 19 (2011) 137, Montreal, Canada. Nejad-Davarani SP, Jiang Q, Peltier S, Bagher-Ebadian H, Noll D, Wang S, Mitsias P, and Chopp M, Implementation of a framework for Studying Changes in the Functional Connectivity Network After Stroke Using Resting state fMRI, Intl. Soc. Mag. Reson. Med. 19 (2011) 4134, Montreal, Canada. Ali MM, Bhuiyan PI, Bagher-Ebadian H, Janic B, knight RA, Ewing JR, and Arbab AS, A new R2/R1 Ratiometric Method to Measure pH with a Dendrimer-based pH-Responsive MRI Contrast Agent, Intl. Soc. Mag. Reson. Med. 19 (2011) 1688, Montreal, Canada. Paudyal R, Bagher-Ebadian H, Knight R, Nagaraja TN, Fenstermacher JD, Ewing JR, Modeling of Look-Locker Estimates of the Magnetic Resonance Imaging Estimate of Longitudinal Relaxation Rate in Tissue After Contrast , Intl. Soc. Mag. Reson. Med. 19 (2011) 2061, Montreal, Canada. Entezarmahdi M, Bagher-Ebadian H, Faghihi R, Prediction of Final Extent of Brain Ischemic Infarction from Acute MR Textural Information using Generalized Linear Regression, European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 4 (112) 2011, Leipzig, Germany. Chwang WB, Jain R, Arbab SA, Bagher-Ebadian H, Ewing JR, and Essig M, Albumin-bound Blood Pool Contrast Agents and Dynamic Contrast-Enhanced (DCE) Brain Tumor Imaging: Assessing Tumor Morphology and Physiology, permeability & Perfusion session, A16, p:84-91, ASNR 50th Annual Meeting & The Foundation of the ASNR Symposium, New York, April 2012. Nejad-Davarani SP, Bagher-Ebadian H, Noorizadeh A, Analytical Model of the Brain Vascular System for Estimation of the Arterial Input Function (AIF) at the Tissue Level", Conference on Bioinformatics and Computational Biology, SA1, BIOCOMP 2012, July 16-19, Las Vegas, USA.

13

Nejad-Davarani SP, Bagher-Ebadian H, Cerghet M, Peltier S, Budaj J, Li L, Noll D, Chopp M and Jiang Q, Assessment of Changes in Cognitive Networks of the Brain in MS Patients using Resting State fMRI Connectivity Analysis, 9th Annual Symposium Medical Imaging – HFH, (2012) Detroit, USA, May-2012, 75(106). Bagher-Ebadian H, Noorizadeh A, Nejad-Davarani SP, Knight R, Nagaraja T, Paudyal R, Brown S, Panda S and Ewing JR, MR Estimation of Arterial Input Function (AIF) in Dual Gradient Echo Sequences Using an Adaptive Model Trained by Standard Radiological AIF, IEEE-IJCNN, 2012: ID 477, Brisbane, Australia 2012. Aryal MP, Bagher-Ebadian H, Panda S, Keenan KA, Nagaraja TN, Ewing JR, Correlation Between MRI Measured Extravascular Extracellular Volume and Cell Counts from Histology in a Rat Model of Cerebral Glioma, 9th Annual Symposium Medical Imaging – HFH, (2012) Detroit, USA, May-2012, 67(97). Bagher-Ebadian H, Nejad-Davarani SP, Ewing JR, An Analytical Approach for Quantification of Errors in Relaxivity Rate Change (ΔR1) Due to Systematic Errors in Dynamic Studies, 9th Annual Symposium Medical Imaging – HFH, (2012) Detroit, USA, May-2012, 77(108). Bagher-Ebadian H, Nejad-Davarani SP, Jain R, Noll D, Jiang Q, Arbab AS, Mikkelsen T, Ewing JR, An Analytical Approach for Quantification and Comparison between Signal Intensity and Longitudinal Relaxation Rate Change (ΔR1) in MR DCE-T1 Studies, Intl. Soc. Mag. Reson. Med. 20 (2012) 6458, Melbourne, Australia. Bagher-Ebadian H, Nejad-Davarani SP, Jain R, Noll D, Jiang Q, Arbab AS, Mikkelsen T, Ewing JR, Comparison of Signal Intensity and Standard Techniques for Estimation of Pharmacokinetic Parameters in DCE-T1 Studies of Glioblastoma: Using Model Selection, Intl. Soc. Mag. Reson. Med. 20 (2012) 6508, Melbourne, Australia. Noorizadeh Vahed-Dehkordi A, Bagher-Ebadian H, Faghihi R, Nejad-Davarani SP, Kamali-Asl A, A Blood Circulatory Model Based Algorithm for Arterial Input Function Detection in MR Brain Perfusion, Conference on Bioinformatics and Computational Biology, BIC7822, BIOCOMP 2012, July 16-19, Las Vegas, USA. Jabari M, Bagher-ebadian H, Nejad-Davarani SP, Faghihi R, Simulation of Diffusion of Water Molecules in a Multi-Orientation System, Conference on Bioinformatics and Computational Biology, MSV7900, BIOCOMP 2012, July 16-19, Las Vegas, USA. Chwang WB, Jain R, Arbab SA, Bagher-Ebadian H, Ewing JR, and Essig M, Albumin-bound Blood Pool Contrast Agents and Dynamic Contrast-Enhanced (DCE) Brain Tumor Imaging: Assessing Tumor Morphology and Physiology, permeability & Perfusion session, 9th Annual Symposium Medical Imaging – HFH, (2012) Detroit, USA, May-2012, 64(94). Ewing JR, Aryal M, Bagher-Ebadian H, Panda S, Karki K, Nagaraja TN, Cabral G, Fenstermacher JoD, Mikkelsen T. Dynamic Contrast Enhanced MRI at 7T in a Rat Model of Cerebral Glioma: Data Analysis and Model Selection. Intl. Soc. Mag. Reson. Med. 20 (2012) 1530, Melbourne, Australia. Nejad-Davarani SP, Gumenyuk V, Bagher-Ebadian H, Peltier S, Budaj J,Drake CL, Noll D, Jiang Q, Chopp M, Comparison of the Functional Brain Connectivity Network in Night

14

Shift Workers With and Without Shift Work Disorder: A Resting State fMRI Analysis, Intl. Soc. Mag. Reson. Med. 21 (April 2013) 6769, Salt Lake City, USA. Aryal MP, Nagaraja TN, Keenan KA, Bagher-Ebadian H, Panda SP, Brown S, Ewing JR, Logan Plot Estimates of Tracer Distribution Volume from Dynamic Contrast Enhanced MRI Data and Tumor Cellularity in a Rat Model of Cerebral Glioma at 7T, Intl. Soc. Mag. Reson. Med. 21 (April 2013) 5321, Salt Lake City, USA. Nazem-Zadeh MR, Schwalb JM, Bagher-Ebadian H, Hamidian H, Soltanian-Zadeh H,Diffusion Properties of Bilateral Cingulum May Help in Lateralizing Temporal Lobe Epilepsy, 10th Annual Symposium Medical Imaging – HFH, (2013) Detroit, USA. Nazem-Zadeh MR, Schwalb JM, Elisevich KV, Bagher-Ebadian H, Soltanian-Zadeh H,Lateralization of Temporal Lobe Epilepsy by Anaysis Asymetric Fractional Anisotropy in the Cingulum, 2013 Annual Meeting of the American Epilepsy Society, Washington, DC, December 6 – 10, 2013. Bagher-Ebadian H, Jain R, Narang J, Soltanian-Zadeh H, Adaptive Model for Direct Estimation of Hemodynamic Parameters in MR Perfusion Studies: Comparison and Evaluation Using CT Perfusion and Singular Value Decomposition Technique, Intl. Soc. Mag. Reson. Med. 21 (April 2013) 6431, Salt Lake City, USA. Nejad-Davarani PN, Bagher-Ebadian H, Chwang W, Schultz L,VanSlooten A, Arbab AS, Jain R, Comparison of Manually Selected Arterial Input Function and Standard Radiological Arterial Input Function in MR Estimation of Permeability Parameters Using Model Selection Approach, Intl. Soc. Mag. Reson. Med. 21 (April 2013) 6550, Salt Lake City, USA. Bagher-Ebadian H, Nejad-Davarani SP, Ewing JR, Soltanian-Zadeh H, Model Averaging in Estimation of Permeability Parameters from Dynamic Contrast Enhanced Magnetic Resonance Images (DCE-MRI), 11th Annual Symposium Medical Imaging – HFH, (2013) Detroit, USA. Noorizadeh AVD, Bagher-Ebadian H, Jain R, Faghihi R, Kamali-Asl A, Ewing JR, Arterial Input Function Detection in MR Brain Perfusion: Using a Model-Based Objective Function, 11th Annual Symposium Medical Imaging – HFH, (2013) Detroit, USA. Nejad Davarani SP, Bagher-Ebadian H, Ewing JR, Jain R, Noll D, Chopp M, Jiang Q, A Novel Parametric Model of the Brain Vascular System for Estimation of the Arterial Input Function Distortion in Dynamic Contrast Enhanced Imaging Applications, 11th Annual Symposium Medical Imaging – HFH, (2013) Detroit, USA. Chwang WB, Jain R, Nejad-Davarani SP, Iskander ASM, VanSlooten A, Schultz L, Noorizadeh A, Ewing JR, Arbab AS, Bagher-Ebadian H, Measurement of Rat Brain Tumor Kinetics Using an intravascular MR Contrast Agent and DCE-T1 Nested Model Selection, Intl. Soc. Mag. Reson. Med. 21 (April 2013) 6351, Salt Lake City, USA. Bagher-Ebadian H, Hamidian H, Jafari-Khouzani K, Schwab J, Spanaki-Varelas M, Wasade V, Soltanian-Zadeh H, Localized Quantitative Analysis of Positron Emission Tomography for Temporal Lobe Epilepsy Lateralization and Surgical Intervention, Curing the Epilepsies 2013: Pathways Forward", NIH-NINDS-sponsored, Award winner, April 17-19 (2013) at the NIH, Bethesda, MD, USA.

15

Bagher-Ebadian H, Nazem-Zadeh M, Schwalb JM, Hassane A, Soltanian-Zadeh H, Equilibrium Model for Magnetic Resonance Grading of Hippocampal Sclerosis in Temporal Lobe Epilepsy, Intl. Soc. Mag. Reson. Med. 21 (May 2014) 5029, Milan, Italy. Bagher-Ebadian H, Ewing JR, Nejad-Davarani SP, Moradi H, Faghihi R, Jain R, Mikkelsen T, Scarpace L, Soltanian-Zadeh H, Comparison of Logan Plot Analysis and Nested Model Selection Technique for MR Estimation of Distribution Volume in Human Brain Tumor at 3Tesla, Intl. Soc. Mag. Reson. Med. 21 (May 2014) 5118, Milan, Italy. Bagher-Ebadian H, Nejad-Davarani SP, Ewing JR, Mikkelsen T, Jain R, Scarpace L, Soltanian-Zadeh H, MR Estimation of Permeability Parameters in Dynamic Contrast Enhanced Studies Using Model Averaging Technique and Nested Model Selection Method, Intl. Soc. Mag. Reson. Med. 21 (May 2014) 5200, Milan, Italy. Bagher-Ebadian H, Nejad-Davaran SP, Ewing JR, Soltanian-Zadeh H, Error Quantification in Relaxivity Rate Change (ΔR1) Due to Systematic Errors in Dynamic Contrast Enhanced MR Studies, Intl. Soc. Mag. Reson. Med. 21 (May 2014) 5220, Milan, Italy. Bagher-Ebadian H, Luby M, Ewing JR, Mitsias P, Soltanian-Zadeh H, Prediction of Tissue Recovery in Chronic Stroke Using Adaptive Models and Acute MR Information, Intl. Soc. Mag. Reson. Med. 21 (May 2014) 5266, Milan, Italy. Nejad-Davarani SP, Bagher-Ebadian H, Ewing JR, Chopp M,Noll DC, Jiang Q, MR Estimation of the Arterial Input Function at the Tissue Level Using a Novel Cerebral Vascular Model, Intl. Soc. Mag. Reson. Med. 21 (May 2014) 7547, Milan, Italy. Nejad-Davarani SP, Bagher-Ebadian H, Chwang WB, Ewing JR, VanSlooten A, Schultz L, Arbab AS, Jain R, Comparison of Manually Selected Arterial Input Function and Standard Radiological Arterial Input Function in MR Estimation of Permeability Parameters Using Model Selection Approach, Intl. Soc. Mag. Reson. Med. 21 (May 2014) 7643, Milan, Italy. Bagher-Ebadian H, Luby M, Ewing JR, Mitsias P, Soltanian-Zadeh H, Prediction of Tissue Recovery in Chronic Stroke Using Acute MR Information and Adaptive Models, 12th Annual Symposium Medical Imaging – HFH, (2014) Detroit, USA. Nazem-Zadeh MR, Schwalb JM, Bagher-Ebadian H, Mahmoudi F, Hosseini MP, Hamidian H, Hassane A, Meci O, Vijay H, Emari M, Soltanian-Zadeh H, Lateralization of Temporal Lobe Epilepsy Using Intrinsic Property of Water Diffusion in Fornix Crus, Intl. Soc. Mag. Reson. Med. 21 (May 2014) 7990, Milan, Italy. Ewing JR, Aryal MP, Nagaraja TN, Keenan KA, Bagher-Ebadian H, Panda S, Brown SL,Toward an MRI Estimate of Tumor Interstitial Pressure: Porosity in the Tumor Rim, Intl. Soc. Mag. Reson. Med. 21 (May 2014) 7412, Milan, Italy. Bagher-Ebadian H, Mitsias PD, Ewing JR, Soltanian-Zadeh H, Prediction of Ischemic Brain Penumbra Using Acute MR Information and Inelastic Collision Model, American Academy of Neurology Conference (April 2014) P2, 017, pp 56, Philadelphia PA, USA. Nazem-Zadeh MR, Schwalb JM, Elisevich K, Bagher-Ebadian H, Soltanian-Zadeh H, Response-driven Models based on MRI and SPECT findings on Hippocampus for Lateralization of Temporal Lobe Epilepsy, American Academy of Neurology Conference (April 2014) P6, 190, pp108, Philadelphia PA, USA.

16

Nazem-Zadeh MR, Schwalb JM, Bagher-Ebadian H, Jafari-Khouzani K, Elisevich KV, Soltanian-Zadeh H, A Bayesian Averaged Response- Driven Mutinomial Model for Lateralization of Temporal Lobe Epilepsy, IEEE International Symposium of Biomedical Imaging, (SBI 2014). Bagher-Ebadian H, Nazem-Zadeh MR, Schwalb JM, Hassane A, Soltanian-Zadeh H,Magnetic Resonance Grading of Hippocampal Sclerosis in Temporal Lobe Epilepsy Patients Using an Equilibrium Model, American Academy of Neurology Conference (April 2014) P6, 192, pp108, Philadelphia PA, USA.

Book Chapters

1. Hassan Bagher-Ebadian and Seyed Ali Mohammadi-Rad, “Nuclear Medicine” in

Encyclopedia of Global Health, Rolf Janke (Ed), SAGE Publications, Inc., Thousand Oaks, California, December 2006.

2. Hassan Bagher-Ebadian, “Air Filters/Scrubbers” in Vol. 9, Green Series E-reference, Green Health, Paul Robbins, Oladele Ogunseitan, SAGE Publications, Inc., Thousand Oaks, California, April 2009.

3. Hassan Bagher-Ebadian, “Ozone” in Vol. 9, Green Series E-reference, Green Health, Paul Robbins, Oladele Ogunseitan, SAGE Publications, Inc., Thousand Oaks, California, April 2009.

4. Hassan Bagher-Ebadian, “Radon and Basements” in Vol. 9, Green Series E-reference, Green Health, Paul Robbins, Oladele Ogunseitan, SAGE Publications, Inc., Thousand Oaks, California, April 2009.

5. Hassan Bagher-Ebadian, “Ultraviolet Radiation” in Vol. 9, Green Series E-reference, Green Health, Paul Robbins, Oladele Ogunseitan, SAGE Publications, Inc., Thousand Oaks, California, April 2009.

6. Hassan Bagher-Ebadian, “Carbon Filters” in Vol. 10, Green Series E-reference, Green Health, Paul Robbins, Oladele Ogunseitan, SAGE Publications, Inc., Thousand Oaks, California, April 2010.

Book Chapters under preparation

1. Hassan Bagher-Ebadian and James R. Ewing, “MRI Measurement of Ischemic Brain

Outcome Using Artificial Neural Network” in Artificial Neural Networks, Rolf Janke (Ed), Intech. Publications Inc., 1070 Vienna, Austria, European Union, Nov. 2013.

2. James R. Ewing and Hassan Bagher-Ebadian, “Model Selection in Measures of Vascular Permeability using Dynamic Contrast Enhanced MRI: Experimental and Clinical Applications”, NMR in Biomedicine, DCE Chapter, Dec. 2013, in press

Patent/Invention

Avicenna Tool (AVCTOOL Version 1.2 - 2013): A Platform for DCE-MR Data Analysis Using Pharmacokinetic Modeling, and Model Selection. By Hassan Bagher-Ebadian and Siamak P. Nejad-Davarani The Departments of Neurology & Radiology, One Ford Place Building, 2F, Image Analysis Lab, Room# 79, Henry Ford Hospital, 1 Ford Place, Detroit, MI 48202 USA

17

Patent by Hassan Bagher-Ebadian and James R. Ewing Title: MRI Estimation of Contrast Agent Concentration Using A Neural Network Approach. Publication No.: WO/2009/020687, International Application No.: PCT/US2008/064165 Publication Date: 12.02.2009, International Filing Date: 19.05.2008 IPC: A61B 5/05 (2006.01), Priority Data: 60/938,849 18.05.2007 US Agent: KAMP, James, F.; Rader, Fishman & Grauer Pllc, 39533 Woodward Avenue, Suite 140, Bloomfield Hills, MI 48304 (US).

Funded/Approved Research Projects (Ongoing/Completed)

R03 NS079982 (Bagher-Ebadian, Soltanian-Zadeh, Ewing, and Mitsias) 09/15/2013 – 09/14/2015 NIH - Prediction of Stroke Outcome from Early MRI Data Using Adaptive Models Role: Principle Investigator In this study, it is proposed to apply Adaptive Models such as Artificial Neural Network, Generalized Linear Model, Kohonen Multi-Parametric Self-Organizing Map and Inelastic Collision Model to acute MR data sets of human studies gathered from the Stroke Image Repository (STIR) database to predict tissue outcome at three month. This will allow the proposed techniques to be tested and refined, thus selecting a best early predictor of outcome in stroke. Once a predictor of untreated outcome is established, an examination of MRI changes will be conducted in both untreated and treated populations. This latter examination will allow the description of the connection of the proposed predictors to clinical measures to be refined. we will produce a surrogate MRI outcome measure that will be quickly available (essentially in real time) to robustly predict the outcome MRI image of stroke in the brain at the acute and subacute stages of stroke. This may allow the real-time assessment of treatment effects in acute and subacute stroke patients, thus fundamentally changing treatment paradigms. Nathanson (Award) Funding: (Bagher-Ebadian) 06/01/2012 – 12/31/2013

Role: Principle Investigator Study and identification of best biomarkers in Breast Cancer study Using Shutter-Speed Model and Standard Model in DCE-MRI. This study focuses on the applications of Standard and Shutter-Speed models for unbiased estimation of permeability parameters in breast cancer DCE-MRI studies to prevent and reduce the False-Positive fraction. Mentored Grant CA10437-01: (Bagher-Ebadian ) 01/01/08 – 12/08/2012 HFH - MRI Direct Estimate of 3T/7T-MR Contrast Agent Concentration Using Adaptive Systems Role: Principle - Investigator This work serves as a proof of principle and lends credence to the proposal that the method can be extended to other field strengths and MRI input sets associated with faster MRI sequences. It is our general aim to translate and extend this approach for estimating tissue CA concentration to human studies in a clinical 3T system. In order to do that, we will first train an ANN to estimate CA tissue concentration in an animal model of cerebral tumor.

STIR: (Bagher-Ebadian, Mitsiais, & Ewing) 10/01/2012 – 12/31/2014

Role: Principle Investigator Study of Time Invariant Predictor of Stroke Outcome Using Artificial Neural Networks This study has been approved and MR information of 186 patients has been released to our group for constructing an adaptive neural network for a time invariant prediction of the stroke outcome at different time points (acute and subacute).

18

R01 CA135329-01: (Ewing & Bagher-Ebadian) 04/01/09 – 03/31/14 NIH - MRI Biomarkers of Response in Cerebral Tumors Role: Co-Investigator This application will use magnetic resonance (MR) contrast agents and MR detection to measure parameters of vascular physiology in cerebral tumors. In animal models of cerebral tumor these parameters, singly and in combination, will be assessed as predictors of response to antiangiogenic and vascular disrupting therapies. R03 NS061170 (Ewing & Bagher-Ebadian ) 07/01/07 – 06/30/09 NIH - Prediction of Stroke Outcome from Early MRI Data Using an Adaptive Neural Network Role: Co-Investigator To produce a surrogate MRI outcome measure that will be quickly available (essentially in real time) to predict the final results of stroke in the parenchyma of the brain, at the acute and subacute stages of stroke. This will allow the real-time assessment of treatment effects in acute and subacute stroke patients.

Graduate Thesis and Dissertation Supervised/ Under Supervision

Ph.D. Dissertation: Mr. Siamak P. Nejad Davarani First Advisor: Douglas Noll Co-Advisor: Hassan Bagher-Ebadian Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA. Title: Quantitative Measurements of Physiological Parameters in MR Dynamic Contrast Enhanced Studies Using Analytical Models, Proposal approved on September 2011, Defended on Sept. 2013. Ph.D. Dissertation: Mrs. Azimeh Noorizadeh-Dehkordi First Advisor: Alireza Kamali-Asl Co-Advisor: Hassan Bagher-Ebadian Department of Nuclear Engineering, University of Shahid Beheshti, Tehran, Iran. Title: An Integrated Quantitative Model for Grading and Characterization of GBM Brain Tumors Using DCE-MR Pharmacokinetic Model Selection, Proposal approved on February 2014.

Msc. Thesis: Mr. Couhsar Nassiry-Hanis

Frist Advisor: Reza Faghihi Second Advisor: Hassan Bagher-Ebadian Department of Mechanical Engineering, School of Engineering, Shiraz University, Shiraz, Iran. Title: Brain Tissue Characterization in MR Dynamic Contrast Enhanced (DCE) Proposal Approved on: 2008, Defended on Jan 2010. Msc. Thesis: Mrs. Azimeh Noorizadeh First Advisor: Hassan Bagher-Ebadian Second Advisor: Reza Faghihi Consultant: Mohammad Hadi Bagheri Department of Mechanical Engineering, School of Engineering, Shiraz University, Shiraz, Iran. Title: Automatic Detection of Arterial Input Function (AIF) in MR Dynamic Contrast Enhanced (DCE)

19

Proposal Approved on: 2008, Defended on June 2010. Msc. Thesis: Mr. Mohammad Entezarmahdi. First Advisor: Hassan Bagher-Ebadian Second Advisor: Reza Faghihi Consultant: Mohammad Hadi Bagheri Department of Mechanical Engineering, School of Engineering, Shiraz University, Shiraz, Iran. Title: Acute Prediction of Brain Ischemic Pattern in Chronic Stage Using MR modalities. Proposal Approved on: 2009, Defended on June 2010.

Msc. Thesis: Mr. Masoud Jabari. First Advisor: Hassan Bagher-Ebadian Second Advisors: Reza Faghihi and Jiang Quan Consultant: Mohammad Hadi Bagheri Department of Mechanical Engineering, School of Engineering, Shiraz University, Shiraz, Iran. Title: Quantification and Investigation of Water Diffusivity and its application on Fiber Crossing in DTI using Maxwell-Boltzmann Simulation Proposal Approved on: 2010, Defended on June 2012. Msc. Thesis: Mr. Hamed Moradi. First Advisor: Hassan Bagher-Ebadian Second Advisors: Reza Faghihi and Jiang Quan Consultant: Mohammad Hadi Bagheri Department of Mechanical Engineering, School of Engineering, Shiraz University, Shiraz, Iran. Title: Survival Rate Prediction in GBM patients Using Standard Model DCE-MRI analysis and Nested Model Selection. Proposal Approved on: June 2012, Defended on June 2013. Msc. Thesis: Mr. Mohammad Reza Mohammadian First Advisor: Alireza Kamali-Asl Co-Advisor: Hassan Bagher-Ebadian Department of Nuclear Engineering, University of Shahid Beheshti, Tehran, Iran. Title: Model Averaging in DCE-MRI analysis of GBM patients. Proposal is supposed to be submitted: May 2014. Msc. Thesis: Mr. Abbas kargar First Advisor: Alireza Kamali-Asl Co-Advisor: Hassan Bagher-Ebadian Department of Nuclear Engineering, University of Shahid Beheshti, Tehran, Iran. Title: MR Outcome Prediction in Patients with Brain Ischemia. Proposal is supposed to be submitted: May 2014.

Special Skills:

MR Imaging pulse design and programming, Matlab programming, Unix/Linux, Skill in C-programming and constructing Neuro- Pipe structures for reconstruction and post processing of MR data, Programming in X-Windows environment in Solaris, and Apple, Watcom C++ & C++, Interface programming, optimization & treatment planning in RT, data reconstruction, post processing and quality control in MRI, CT and Nuclear Medicine.

20

Signature:

Name Date: Hassan Bagher-Ebadian May. 7th 2014