1

CURRICULUMVITAE

DateUpdated:28October2016Name:

DAVIDBRUCEMATCHAR,MD,FACP,FAHA

Appointments:

InauguralDirectorandProfessor,PrograminHealthServicesandSystemsResearch,Duke-NUSMedicalSchool,Singapore

Professor,DepartmentofInternalMedicine(GeneralInternalMedicine)DukeUniversityMedicalCenter,Durham,NCDirector,DukeCenterofClinicalHealthPolicyResearch

MedicalLicensure:

NorthCarolinaLicense#27243

Specialtycertificationanddate:

DiplomainInternalMedicine,1984

Citizenof: USA

Education: 1972 PikesvilleSeniorHighSchool,Baltimore,MD

1976,AB DepartmentofStatistics,PrincetonUniversity,Princeton,NJ

1976 SchoolofPublicHealth,HarvardUniversity,Boston,MA

1977 EpidemiologyIntelligenceService,TrainingCourse,CenterforDiseaseControl,Atlanta,GA

1980,MD SchoolofMedicine,UniversityofMaryland,Baltimore,MD

1983 FellowinGeneralInternalMedicineDepartmentofMedicine,DukeUniversityMedicalCenter,

Durham,NC

1984 VisitingFellow,DivisionofClinicalDecisionMaking,NewEnglandMedicalCenter,Boston,MA

ProfessionalExperience:1975 Statistician,CenterforEnvironmentalStudies,Princeton,NJ

1977 AssistantStatistician,CentersforDiseaseControl,Atlanta,GA

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1980 Intern,UniversityofMarylandHospital,DepartmentofMedicine,Baltimore,MD

1981 Junior/SeniorAssistantResident,UniversityofMarylandHospital,DepartmentofMedicine,Baltimore,MD

1983 Instructor,PhysicalDiagnosis,DukeUniversityMedicalCenter,Durham,NC

1985 ResearchAssociate,HealthServicesResearchFieldProgram,VAMedicalCenter,Durham,NC

1985–1987 AssociateinMedicine,DivisionofGeneralInternalMedicine,DepartmentofMedicine,DukeUniversityMedicalCenter,Durham,NC

1985–2008 StaffPhysician,AmbulatoryCareService,VAMedicalCenter,Durham,NC

1987–1993 AssistantProfessor,DivisionofGeneralInternalMedicine,DepartmentofMedicine,DukeUniversityMedicalCenter,Durham,NC

1985 MedicalDirector,HospitalBasedHomeCareProgram,VAMedicalCenter,Durham,NC

1988 Director,CenterforHealthPolicyResearchandEducation(renamed:CenterforClinicalHealthPolicyResearch,1997),DukeUniversityMedicalCenter,Durham,NC

1989–1994 AdjunctAssistantProfessor,DepartmentofHealthPolicyandAdministrationSchoolofPublicHealth,UniversityofNorthCarolina,ChapelHill,NC

1989–1994 AssistantResearchProfessor,InstituteofStatisticsandDecisionSciences,DukeUniversityMedicalCenter,Durham,NC

1993–1999 AssociateProfessorwithTenure,DepartmentofMedicine,DukeUniversityMedicalCenter,Durham,NC

1994–1999 AdjunctAssociateProfessor,DepartmentofHealthPolicyandAdministrationSchoolofPublicHealth,UniversityofNorthCarolina,ChapelHill,NC

1996

SeniorFellow,CenterfortheStudyofAgingandHumanDevelopment,DukeUniversityMedicalCenter,Durham,NC

1997–2008 Director,Evidence-basedPracticeCenter,DukeUniversityMedicalCenter,Durham,NC

1999 ProfessorwithTenure,DepartmentofMedicine,DukeUniversityMedicalCenter,Durham,NC

2008–Present ProfessorandInauguralDirector,PrograminHealthServicesandSystemsResearch,Duke-NUSMedicalSchool,Singapore

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2009–Present20152015–20182016 2016–20182016–2019

Professor,DepartmentofPathology,DukeUniversityMedicalCenter,Durham,NCCo-director,HealthServicesResearchInstituteVisitingScientist,DivisionofResearch,HealthServicesResearchUnit,SingaporeGeneralHospitalFellow,AcademyofMedicine,Singapore,ChapterofClinicianScientistsAdjunctFaculty,GeriatricEducationandResearchInstitute(GERI),AlexandraHealthSystemResearchScientist,NationalHeartResearchInstituteSingapore,NationalHeartCentreSingapore

Publications:

1. MatcharDB,CoffeyCE,FeussnerJR.Latereportingofsuddenvisionloss.NorthCarolinaMedicalJournal.45(4):211-212,1984.

2. HarrellFE,LeeKL,MatcharDB,ReichertTA.Regression-modelsforprognosticprediction-advantages,problems,andsuggestedsolutions.CancerTreatmentReports.69(10):1071-1077,1985.

3. MatcharDB,FeussnerJR.Laboratorytestsinthediagnosisofvitamin-B12(cobalamin)deficiency.NorthCarolinaMedicalJournal.47(3):118-120,1986.

4. MatcharDB,FeussnerJR,WatsonDJ,WilkinsonJ,MillingtonDS,GaleD.Significanceoflowserumvitamin-B12levelsintheelderly.JournaloftheAmericanGeriatricsSociety.34(9):680-681,1986.

5. MatcharDB,PaukerSG.Transientischemicattacksinamanwithcoronary-arterydisease-twostrategiesneckandneck.MedicalDecisionMaking.6(4):239-249,1986.

6. FeussnerJR,SimelDL,MatcharDB.Quantitativeapproachestoclinicaldiagnosisofcancerinelderlypatients.ClinicsinGeriatricMedicine.3:447461,1987.

7. MatcharDB,FeussnerJR,MillingtonDS,WilkinsonRH,WatsonDJ,GaleD.Isotope-dilutionassayforurinarymethylmalonicacidinthediagnosisofvitamin-B12deficiency-aprospectiveclinical-evaluation.AnnalsofInternalMedicine.106(5):707-710,1987.

8. MatcharDB,PaukerSG.Endarterectomyincarotid-arterydisease-adecision-analysis.JAMA-JournaloftheAmericanMedicalAssociation.258(6):793-798,1987.

9. SimelDL,FeussnerJR,DelongER,MatcharDB.Intermediate,indeterminate,anduninterpretablediagnostictestresults.MedicalDecisionMaking.7(2):107-114,1987.

10. FeussnerJR,MatcharDB.Whenandhowtostudythecarotidarteries.AnnalsofInternalMedicine.109(10):805-818,1988.

11. FeussnerJR,MatcharDB.Diagnosticevaluationofthecarotidarteries.AnnalsofInternalMedicine.109(10):835-837,1988.

12. SimelDL,MatcharDB,PiscitelliJT.Routineintravenouspyelogramsbeforehysterectomyincasesofbenigndisease-possiblyeffective,definitelyexpensive.AmericanJournalofObstetricsandGynecology.159(5):1049-1053,1988.

13. SimelDL,PiscitelliJ,MatcharDB.Intravenouspyelographybeforehysterectomy.AnnalsofInternalMedicine.111(6):541-541,1989.

14. GoldsteinLB,MatcharDB,MorganlanderJ,DavisJN.Theinfluenceofdrugsontherecoveryofsensorimotorfunctionafterstroke.JournalofNeurologicalRehabilitation.4:137-144,1990.

15. GusbergSB,LowmanJ,FlemingID,BeahrsOH,HenleyCE,MixsonWT,McGivneyWT,MatcharDB,MortensonLE,HoganCM.Healthprofessionalconcernsinthepracticesetting.Cancer.65(10):2413-2414,1990.

16. MatcharDB.Technology-assessmentandguidelinedevelopment-concernsandopportunitiesforacademicgeneralinternists.AmericanJournaloftheMedicalSciences.300(3):171-172,1990.

17. MatcharDB.Decision-makinginthefaceofuncertainty-thecaseofcarotidendarterectomy.MayoClinicProceedings.65(5):756-760,1990.

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18. MatcharDB,GewekeJF,SimelDL,FeussnerJR.Uniformpriorsaren’tathingofthepast-response.MedicalDecisionMaking.10(2):114-115,1990.

19. MatcharDB,SimelDL,GewekeJF,FeussnerJR.ABayesianmethodforevaluatingmedicaltestoperatingcharacteristicswhensomepatientsconditionsfailtobediagnosedbythereference-standard.MedicalDecisionMaking.10(2):102-112,1990.

20. MurphyDJ,MatcharDB.Life-sustainingtherapy-amodelforappropriateuse.JAMA-JournaloftheAmericanMedicalAssociation.264(16):2103-2108,1990.

21. HornerRD,MatcharDB,DivineGW,FeussnerJR.Racialvariationsinischemicstrokerelatedphysicalandfunctionalimpairments.Stroke.22(12):1497-1501,1991.

22. LinzerM,PrystowskyEN,DivineGW,MatcharDB,SamsaG,HarrellF,PressleyJC,PryorDB.Predictingtheoutcomesofelectrophysiologicstudiesofpatientswithunexplainedsyncope-preliminaryvalidationofaderivedmodel.JournalofGeneralInternalMedicine.6(2):113-120,1991.

23. MatcharDB.Two-SidedMatching:Astudyingame-theoreticmodelingandanalysis.MedicalDecisionMaking.11:229,1991.

24. ShlianD,MatcharDB,SeymannGB.Cost-effectivenessevaluationofmeaslesimmunizationstrategiesonacollegecampus.FamilyPracticeResearchJournal.11:193-207,1991.

25. SimelDL,MatcharDB,FeussnerJR.Diagnostic-testsarenotalwaysblackorwhite-or,allthatglittersisnot(a)gold(standard).JournalofClinicalEpidemiology.44(9):967-970,1991.

26. SimelDL,SamsaGP,MatcharDB.Likelihoodratioswithconfidence-sample-sizeestimationfordiagnosticteststudies.JournalofClinicalEpidemiology.44(8):763-770,1991.

27. DuncanPW,GoldsteinLB,MatcharD,DivineGW,FeussnerJ.Measurementofmotorrecoveryafterstroke-outcomeassessmentandsample-sizerequirements.Stroke.23(8):1084-1089,1992.

28. MatcharDB,DivineGW,HeymanA,FeussnerJR.Theinfluenceofhyperglycemiaonoutcomeofcerebralinfarction.AnnalsofInternalMedicine.117(6):449-456,1992.

29. GlassTA,MatcharDB,BelyeaM,FeussnerJR.Impactofsocialsupportonoutcomeinfirststroke.Stroke.24(1):64-70,1993.

30. MatcharDB,DuncanPW,SamsaGP,WhisnantJP,DefrieseGH,BallardDJ,PaulJE,WitterDM,MitchellJP.Thestrokepreventionpatientoutcomesresearchteam-goalsandmethods.Stroke.24(12):2135-2142,1993.

31. McCroryDC,GoldsteinLB,SamsaGP,OddoneEZ,LandsmanPB,MooreWS,MatcharDB.Predictingcomplicationsofcarotidendarterectomy.Stroke.24(9):1285-1291,1993.

32. OddoneEZ,CowperP,HamiltonJD,MatcharDB,HartiganP,SamsaG,SimberkoffM,FeussnerJR.Cost-effectivenessanalysisofearlyzidovudinetreatmentofHIV-infectedpatients.BritishMedicalJournal.307(6915):1322-1325,1993.

33. OddoneEZ,HornerRD,MongerME,MatcharDB.Racialvariationsintheratesofcarotidangiographyandendarterectomyinpatientswithstrokeandtransientischemicattack.ArchivesofInternalMedicine.153(24):2781-2786,1993.

34. PapadakisMA,LeeKK,BrownerWS,KentDL,MatcharDB,KagawaMK,HallenbeckJ,LeeD,OnishiR,CharlesG.Prognosisofmechanicallyventilatedpatients.WesternJournalofMedicine.159(6):659-664,1993.

35. SchapiraMM,MatcharDB,YoungMJ.Theeffectivenessofovariancancerscreening-adecision-analysismodel.AnnalsofInternalMedicine.118(11):838-843,1993.

36. SimelDL,SamsaGP,MatcharDB.Likelihoodratiosforcontinuoustestresults-makingtheclinicianjobeasierorharder.JournalofClinicalEpidemiology.46(1):85-93,1993.

37. DuncanPW,GoldsteinLB,HornerRD,LandsmanPB,SamsaGP,MatcharDB.Similarmotorrecoveryofupperandlowerextremitiesafterstroke.Stroke.25(6):1181-1188,1994.

38. GoldsteinLB,MatcharDB.ThestrokePORT:secondaryandtertiarypreventionofischemicstroke.HealthReports.6:154-159,1994.

39. GoldsteinLB,MatcharDB.Clinical-assessmentofstroke.JAMA-JournaloftheAmericanMedicalAssociation.271(14):1114-1120,1994.

40. GoldsteinLB,McCroryDC,LandsmanPB,SamsaGP,AncukiewiczM,OddoneEZ,MatcharDB.Multicenterreviewofpreoperativeriskfactorsforcarotidendarterectomyinpatientswithipsilateralsymptoms.Stroke.25(6):1116-1121,1994.

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41. GoldsteinLB,McCroryDC,SamsaGP,OddoneEZ,LandsmanP,MooreWS,MatcharDB.Multicenterreviewofpreoperativeriskfactorsforcarotidendarterectomy(CEA)inpatientswithipsilateralsymptoms.Stroke.25(1):273-273,1994.

42. MatcharDB,DuncanPW.Costofstroke.Stroke:ClinicalUpdates.5:9-12,1994.43. MatcharD,McCroryD,PritchettELC.Managementofatrialfibrillation.AnnalsofInternalMedicine.

121(6):466-467,1994.44. MatcharDB,McCroryDC,BarnettHJM,FeussnerJR.Medicaltreatmentforstroke:prevention.Annalsof

InternalMedicine.121(1):41-53,1994.45. MatcharDB,McCroryDC,BarnettHJM,FeussnerJR,MazzaferriEL,HuthEJ,KerbyGR,KlockeFJ,Kussman

MJ,MartonKI,MulleyAG,MushlinAI,PaldaVA,ThibaultGE,ThomsonGE,HarrisonCE,CasselCK,GullenDJ,WebsterJR,AddingtonW,BerensonR,GaryNE,GreenfieldS,HaywoodJ,LopezAM,TraynorMV,WhiteLJ.Guidelinesformedicaltreatmentforstrokeprevention.AnnalsofInternalMedicine.121(1):54-55,1994.

46. MatcharDB,McCroryDC,MillingtonDS,FeussnerJR.Performanceoftheserumcobalaminassayfordiagnosisofcobalamindeficiency.AmericanJournaloftheMedicalSciences.308(5):276-283,1994.

47. OddoneEZ,SamsaG,MatcharDB.Globaljudgmentsversusdecision-model-facilitatedjudgments-areexpertsinternallyconsistent.MedicalDecisionMaking.14(1):19-26,1994.

48. BennettCL,OddoneE,MatcharDB.Cost-effectivenessmodelsofclinicaltrialsofnewpharmaceuticalsforAIDS-relatedpneumocystiscariniipneumonia:aretheyhelpfultopolicymakers?ClinicalPerformance&QualityHealthCare.3:156-164,1995.

49. BlakeleyDD,OddoneEZ,HasselbladV,SimelDL,MatcharDB.Non-invasivecarotidarterytesting:ameta-analyticreview.AnnalsofInternalMedicine.122(5):360-367,1995.

50. GoldsteinLB,BonitoAJ,MatcharDB,DuncanPW,DefrieseGH,OddoneEZ,PaulJE,AkinDR,SamsaGP.USnationalsurveyofphysicianpracticesforthesecondaryandtertiarypreventionofischemicstroke-design,serviceavailability,andcommonpractices.Stroke.26(9):1607-1615,1995.

51. GoldsteinLB,HasselbladV,MatcharDB,McCroryDC.Comparisonandmetaanalysisofrandomizedtrialsofendarterectomyforsymptomaticcarotidarterystenosis.Neurology.45(11):1965-1970,1995.

52. HornerRD,MatcharDB,DivineGW,FeussnerJR.Relationshipbetweenphysicianspecialtyandtheselectionandoutcomeofischemicstrokepatients.HealthServicesResearch.30(2):275-287,1995.

53. HornerRD,OddoneEZ,MatcharDB.Theoriesexplainingracialdifferencesintheutilizationofdiagnosticandtherapeuticproceduresforcerebrovascular-disease.MilbankQuarterly.73(3):443-462,1995.

54. MatcharDB,McCroryDC,BarnettHJ,FeussnerJR.Medicaltreatmentforstrokeprevention.AnnalsofInternalMedicine.122:235-236,1995.

55. McCroryDC,MatcharDB,SamsaG,SandersLL,PritchettELC.Physicianattitudesaboutanticoagulationfornonvalvularatrialfibrillationintheelderly.ArchivesofInternalMedicine.155(3):277-281,1995.

56. MooreWS,BarnettHJM,BeebeHG,BernsteinEF,BrenerBJ,BrottT,CaplanLR,DayA,GoldstoneJ,HobsonRW,KempczinskiRF,MatcharDB,MaybergMR,NicolaidesAN,NorrisJW,RicottaJJ,RobertsonJT,RutherfordRB,ThomasD,TooleJF,TroutHH,WiebersDO.Guidelinesforcarotidendarterectomy-amultidisciplinaryconsensusstatementfromtheadhoccommittee,AmericanHeartAssociation.Circulation.91(2):566-579,1995.

57. TsevatJ,CookEF,GreenML,MatcharDB,DawsonNV,BrosteSK,WuAW,PhillipsRS,OyeRK,GoldmanL.Healthvaluesoftheseriouslyill.AnnalsofInternalMedicine.122(7):514-520,1995.

58. WestmanEC,MatcharDB,SamsaGP,MulrowCD,WaughRA,FeussnerJR.AccuracyandreliabilityofapicalS3gallopdetection.JournalofGeneralInternalMedicine.10(8):455-457,1995.

59. BennettCL,MatcharD,McCroryD,McLeodDG,CrawfordED,HillnerBE.Cost-effectivemodelsforflutamideforprostatecarcinomapatients-aretheyhelpfultopolicymakers?Cancer.77(9):1854-1861,1996.

60. BoineyL,WinklerR,SarinR,MatcharDB.Combiningpatientutilitywithhealthstatusassessmenttoimprovemedicaldecision-making.JournalofDecisionAnalysis.5:248-258,1996.

61. EdelmanD,MatcharDB,OddoneEZ.Clinicalandradiographicfindingsthatleadtointerventionindiabeticpatientswithfootulcers-anationwidesurveyofprimarycarephysicians.DiabetesCare.19(7):755-757,1996.

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62. GoldsteinLB,BonitoAJ,MatcharDB,DuncanPW,SamsaGP.USnationalsurveyofphysicianpracticesforthesecondaryandtertiarypreventionofischemicstroke-medicaltherapyinpatientswithcarotidarterystenosis.Stroke.27(9):1473-1478,1996.

63. GoldsteinLB,BonitoAJ,MatcharDB,DuncanPW,SamsaGP.USnationalsurveyofphysicianpracticesforthesecondaryandtertiarypreventionofischemicstroke-carotidendarterectomy.Stroke.27(5):801-806,1996.

64. GoldsteinLB,BonitoAJ,MatcharDB,SamsaGP.Nationalsurveyofstrokepreventionpractices:Surgicalmanagement.Stroke.27(1):32-32,1996.

65. GoldsteinLB,BonitoAJ,SamsaGP,MatcharDB.USnationalsurveyofphysicianpracticesforstrokeprevention:Medicaltherapyinpatientswithcarotidarterystenosis.Neurology.46(2):26006-26006,1996.

66. GovertJA,KopitaJM,MatcharD,KussinPS,SamuelsonWM.Cost-effectivenessofcollectingroutinecytologicspecimensduringfiberopticbronchoscopyforendoscopicallyvisiblelungtumor.Chest.109(2):451-456,1996.

67. LeapeLL,HilborneLH,SchwartzJS,BatesDW,RubinHR,SlavinP,ParkRE,WitterDM,PanzerRJ,BrookRH,KellyJ,BluthE,KrouselWoodT,KomaroffA,MatcharD,KahnK,TobacmanJ.Theappropriatenessofcoronaryarterybypassgraftsurgeryinacademicmedicalcenters.AnnalsofInternalMedicine.125(1):8-18,1996.

68. MatcharDB,SamsaGP,CohenSJ.Shouldwejustlettheanticoagulationservicedoit?Theconundrumofanticoagulationforatrialfibrillation.JournalofGeneralInternalMedicine.11(12):768-770,1996.

69. McCroryDC,MatcharDB.Strokeprevention:Theemergingstrategies.HospitalPractice.31(3):123-&,1996.

70. MitchellJB,BallardDJ,WhisnantJP,AmmeringCJ,MatcharDB,SamsaGP.Usingphysicianclaimstoidentifypostoperativecomplicationsofcarotidendarterectomy.HealthServicesResearch.31(2):141-152,1996.

71. MitchellJB,BallardDJ,WhisnantJP,AmmeringCJ,SamsaGP,MatcharDB.Whatroledoneurologistsplayindeterminingthecostsandoutcomesofstrokepatients?Stroke.27(11):1937-1943,1996.

72. OddoneE,MatcharDB,GoldsteinL,PrichettE.Strokepreventioninanasymptomaticpatient.JournalofClinicalOutcomesManagement.3:23-35,1996.

73. BeneschC,WitterDM,WilderAL,DuncanPW,SamsaGP,MatcharDB.Inaccuracyoftheinternationalclassificationofdiseases(ICD-9-CM)inidentifyingthediagnosisofischemiccerebrovasculardisease.Neurology.49(3):660-664,1997.

74. BonitoAJ,SamsaGP,AkinDR,MatcharDB.Useofanon-monetaryincentivetoimprovephysicianresponsestoamailsurvey.AcademicMedicine.72(1):73-73,1997.

75. DuncanPW,SamsaGP,WeinbergerM,GoldsteinLB,BonitoA,WitterDM,EnarsonC,MatcharD.Healthstatusofindividualswithmildstroke.Stroke.28(4):740-745,1997.

76. GoldsteinLB,FarmerA,MatcharDB.Primarycarephysician-reportedsecondaryandtertiarystrokepreventionpractices-acomparisonbetweentheUnitedStatesandtheUnitedKingdom.Stroke.28(4):746-751,1997.

77. MatcharDB.CurrenttreatmentofatrialfibrillationintheUnitedStatesandthepotentialforreductioninstroke.CardiovascularReviews&Reports.8:16-29,1997.

78. MatcharDB,McCroryDC,BennettCL.Treatmentconsiderationsforpersonswithmetastaticprostatecancer:Survivalversusout-of-pocketcosts.Urology.49(2):218-224,1997.

79. MatcharDB,OddoneEZ,McCroryDC,GoldsteinLB,LandsmanPB,SamsaG,BrookRH,KambergC,HilborneL,LeapeL,HornerR.Influenceofprojectedcomplicationratesonestimatedappropriateuseratesforcarotidendarterectomy.HealthServicesResearch.32(3):325-342,1997.

80. MatcharDB,SamsaGP,MatthewsJR,AncukiewiczM,ParmigianiG,HasselbladV,WolfPA,DagostinoRB,LipscombJ.Thestrokepreventionpolicymodel:Linkingevidenceandclinicaldecisions.AnnalsofInternalMedicine.127(8):704-711,1997.

81. ParmigianiG,SamsaGP,AncukiewiczM,LipscombJ,HasselbladV,MatcharDB.Assessinguncertaintyincost-effectivenessanalyses:applicationtoacomplexdecisionmodel.MedicalDecisionMaking.17:390-401,1997.

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82. SamsaGP,CohenSJ,GoldsteinLB,BonitoAJ,DuncanPW,EnarsonC,DeFrieseGH,HornerRD,MatcharDB.Knowledgeofriskamongpatientsatincreasedriskforstroke.Stroke.28(5):916-921,1997.

83. BillerJ,FeinbergWM,CastaldoJE,WhittemoreAD,HarbaughRE,DempseyRJ,CaplanLR,KresowikTF,MatcharDB,TooleJF,EastonJD,AdamsHP,BrassLM,HobsonRW,BrottTG,SternauL.Guidelinesforcarotidendarterectomy-astatementforhealthcareprofessionalsfromaspecialwritinggroupoftheStrokeCouncil,AmericanHeartAssociation.Stroke.29(2):554-562,1998andCirculation.97:501-509,1998.

84. GoldsteinL,CohenSJ,MatcharDB,BonitoAJ,SamsaGP.Physician-reportedreadinesstochangestrokepreventionpractices:implicationsforeducationalprograms.StrokeandCerebrovascularDisease.7(5):358-363,1998.

85. GoldsteinLB,SamsaGP,MatcharDB,OddoneEZ.Multicenterreviewofpreoperativeriskfactorsforendarterectomyforasymptomaticcarotidarterystenosis.Stroke.29(4):750-753,1998.

86. LipscombJ,AncukiewiczM,ParmigianiG,HasselbladV,SamsaG,MatcharDB.Predicatingthecostofillness:acomparisonofalternativemodelsappliedtostroke.MedicalDecisionMaking.18(2Suppl):S39-S56,1998.

87. MatcharDB.Thevalueofstrokepreventionandtreatment.Neurology.51(3):S31-S35,1998.88. NaylorCD,JadadAR,GrahamD,MatcharD,SibbaldWJ,HuxJ.TheOntarioHealthCareEvaluation

NetworkandtheCriticalCareResearchNetworkasvehiclesforresearchtransfer.MedicalDecisionMaking.18(1):16-18,1998.

89. OddoneEZ,HornerRD,DiersT,LipscombJ,McIntyreL,CauffmanC,WhittleJ,PassmanLJ,KroupaL,HeaneyR,MatcharD.Understandingracialvariationintheuseofcarotidendarterectomy:Theroleofaversiontosurgery.JournaloftheNationalMedicalAssociation.90(1):25-33,1998.

90. SamsaGP,MatcharDB,CohenSJ,LipscombJ,AbrahamseP,McCormickM.Aseven-stepmodelforpractice–improvementresearch:descriptionandapplicationtothemanaginganticoagulationservicestrial(MAST).NewMedicine.2:139-146,1998.

91. SamsaGP,MatcharDB,GoldsteinL,BonitoA,DuncanPW,LipscombJ,EnarsonC,WitterD,VenusP,PaulJE,WeinbergerM.Utilitiesformajorstroke:Resultsfromasurveypreferencesamongpersonsatincreasedriskforstroke.AmericanHeartJournal.136(4):703-713,1998.

92. KuoRL,AslanP,AbrahamsePH,MatcharDB,PremingerGM.Incorporationofpatientpreferencesinthetreatmentofupperurinarytractcalculi:Adecisionanalyticalview.JournalofUrology.162(6):1913-1918,1999.

93. MatcharDB,SamsaGP.Theroleofevidencereportsinevidence-basedmedicine:amechanismforlinkingscientificevidenceandpracticeimprovement.JointCommissionJournalonQualityImprovement.25:522-528,1999.

94. MatcharDB,SamsaGP.Usingoutcomesdatatoidentifybestmedicalpractice:Theroleofpolicymodels.Hepatology.29(6):36S-39S,1999.

95. McCroryDC,MatcharDB,BastianL,DattaS,HasselbladV,MyersE,NandaK.Evaluationofcervicalcytology.EvidenceReport/TechnologyAssessmentNumber5.(PreparedbyDukeUniversityunderContractNo.290-97-0014.).AHCPRPublicationNo.99-E010.AgencyforHealthCarePolicyandResearch,Rockville,MD,January1999.Availableathttp://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.6794.

96. OddoneEZ,HornerRD,SloaneR,McIntyreL,WardA,WhittleJ,PassmanLJ,KroupaL,HeaneyR,DiemS,MatcharD.Race,presentingsignsandsymptoms,useofcarotidarteryimaging,andappropriatenessofcarotidendarterectomy.Stroke.30(7):1350-1356,1999.

97. SamsaG,EdelmanD,RothmanML,WilliamsGR,LipscombJ,MatcharD.Determiningclinicallyimportantdifferencesinhealthstatusmeasures-ageneralapproachwithillustrationtotheHealthUtilitiesIndexMarkII.Pharmacoeconomics.15(2):141-155,1999.

98. SamsaGP,BianJ,LipscombJ,MatcharDB.Epidemiologyofrecurrentcerebralinfarction-aMedicareclaims-basedcomparisonoffirstandrecurrentstrokeson2-yearsurvivalandcost.Stroke.30(2):338-349,1999.

99. SamsaGP,ReutterRA,ParmigianiG,AncukiewiczM,AbrahamseP,LipscombJ,MatcharDB.Performingcost-effectivenessanalysisbyintegratingrandomizedtrialdatawithacomprehensivedecision

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model:applicationtotreatmentofacuteischemicstroke.JournalofClinicalEpidemiology.52(3):259-271,1999.

100. WilliamsGR,JiangJG,MatcharDB,SamsaGP.Incidenceandoccurrenceoftotal(first-everandrecurrent)stroke.Stroke.30(12):2523-2528,1999.

101. BosworthHB,HornerRD,EdwardsLJ,MatcharDB,TeamVAS.Depressionandotherdeterminantsofvaluesplacedoncurrenthealthstatebystrokepatientsevidencefromthevaacutestroke(VAST)study.Stroke.31(11):2603-2609,2000.

102. GoldsteinLB,BianJ,SamsaGP,BonitoAJ,LuxLJ,MatcharDB.Newtransientischemicattackandstroke-outpatientmanagementbyprimarycarephysicians.ArchivesofInternalMedicine.160(19):2941-2946,2000.

103. JonesMR,HornerRD,EdwardsLJ,HoffJ,ArmstrongSB,Smith-HammondCA,MatcharDB,OddoneEZ.Racialvariationininitialstrokeseverity.Stroke.31(3):563-567,2000.

104. KrumholzHM,BrassLM,EveryNR,SpertusJA,BazzarreT,CohenDJ,HlatkyMA,PetersonED,RadfordMJ,WeintraubWS,CannonCP,EllerbeckEF,McNeilBJ,RyanTJ,SmithSC,BakerDW,AshtonCM,DunbarSB,FriesingerGC,HavranekEP,KonstamM,OrdinDL,PinaIL,PittB,DeLongER,EagleRA,NormandSL,MarkDB,McAllisterBD,ThomasJW,DuncanPW,GoldsteinLB,GorelickPB,HincheyJA,MatcharDB,NilasenaD,WennbergD,WilliamsLS,WolfPA,QualityCareOutcomesResCVDS.Measuringandimprovingqualityofcare-areportfromtheAmericanHeartAssociation/AmericanCollegeofCardiologyFirstScientificForumonAssessmentofHealthcareQualityinCardiovascularDiseaseandStroke.Stroke.31(4):1002-1012,2000.

105. MatcharDB.TreatingQALYSwithaheavydoseofsocialvalues-isthecureworththecost?MedicalCare.38(9):889-891,2000.

106. MatcharDB,McCroryDC,GrayRN.Towardevidence-basedmanagementofmigraine.JAMA-JournaloftheAmericanMedicalAssociation.284(20):2640-2641,2000.

107. MatcharDB,SamsaGP,CohenSJ,OddoneEZ.Communityimpactofanticoagulationservices:rationaleanddesignofthemanaginganticoagulationservicestrial(MAST).JournalofThrombosisandThrombolysis.9(Suppl1):S7-S11,2000.

108. McCroryDC,BrownCB,GrayRN,GoslinRE,KolimagaJT,MacIntyreNR,OddoneEZ,MatcharDB.Managementofacuteexacerbationsofchronicobstructivepulmonarydisease.EvidenceReport/TechnologyAssessmentNumber19.(PreparedbyDukeEvidence-basedPracticeCenter,ContractNo.290-97-0014).AHRQPublicationNo.01-E003.AgencyforHealthcareResearchandQuality,RockvilleMD,September2000.Availableathttp://www.ahrq.gov/clinic/evrptfiles.htm#copd.

109. MitchellJB,BallardDJ,MatcharDB,WhisnantJP,SamsaGP.Racialvariationintreatmentfortransientischemicattacks:Impactofparticipationbyneurologists.HealthServicesResearch.34(7):1413-1428,2000.

110. MyersER,McCroryDC,NandaK,BastianL,MatcharDB.Mathematicalmodelforthenaturalhistoryofhumanpapillomavirusinfectionandcervicalcarcinogenesis.AmericanJournalofEpidemiology.151(12):1158-1171,2000.

111. MyersER,McCroryDC,SubramanianS,McCallN,NandaK,DattaS,MatcharDB.Settingthetargetforabettercervicalscreeningtest:characteristicsofacost-effectivetestforcervicalneoplasiascreening.ObstetricsandGynecology.96(5):645-652,2000.

112. NandaK,McCroryDC,MyersER,BastianLA,HasselbladV,HickeyJD,MatcharDB.AccuracyofthePapanicolaoutestinscreeningforandfollow-upofcervicalcytologicabnormalities:Asystematicreview.AnnalsofInternalMedicine.132(10):810-819,2000.

113. OddoneE,BoossJ,BrassLM,CoullB,GoldsteinL,GorelickP,HornerR,MatcharDB,ProvenzaleJ,KaplanL.AcutestrokemanagementintheVA:atoolboxtoassistpatientcare.FederalPractitioner.17:40-58,2000.

114. RutschmannOT,MatcharDB.Economicsoflow-molecularweightheparins.AmericanJournalofManagedCare.6(20):S1054-S1065,2000.

115. SamsaG,MatcharD.Cancontinuousqualityimprovementbeassessedusingrandomizedtrials?HealthServicesResearch.35(3):687-700,2000.

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116. SamsaGP,MatcharDB.Relationshipbetweentestfrequencyandoutcomesofanticoagulation:Aliteraturereviewandcommentarywithimplicationsforthedesignofrandomizedtrialsofpatientself-management.JournalofThrombosisandThrombolysis.9(3):283-292,2000.

117. SamsaGP,MatcharDB,GoldsteinLB,BonitoAJ,LuxLJ,WitterDM,BianJ.Qualityofanticoagulationmanagementamongpatientswithatrialfibrillation-resultsofareviewofmedicalrecordsfrom2communities.ArchivesofInternalMedicine.160(7):967-973,2000.

118. Frishberg,BenjaminM.,JayH.Rosenberg,DavidB.Matchar,DouglasC.McCrory,MichaelP.Pietrzak,ToddD.Rozen,andStephenD.Silberstein."Evidence-basedguidelinesintheprimarycaresetting:neuroimaginginpatientswithnonacuteheadache."URL:http://www.aan.com/public/practiceguidelines(2000).

119. DalenJE,HirshJ,GuyattGH.SixthACCPconsensusconferenceonantithrombotictherapy:managingoralanticoagulanttherapy.QuickReferenceGuide.AmericanCollegeofPhysicians,NorthbrookIL,January2001.Availableathttp://www.chestnet.org/downloads/guidelines/antithrombotic/qrg.pdf.

120. AnsellJ,HirshJ,DalenJ,BusseyH,AndersonD,PollerL,JacobsonA,DeykinD,MatcharD.Managingoralanticoagulanttherapy.Chest.119(1):22S-38S,2001.

121. GoldsteinLB,JonesMR,MatcharDB,EdwardsLJ,HoffJ,ChilukuriV,ArmstrongSB,HornerRD.ImprovingthereliabilityofstrokesubgroupclassificationusingthetrialofORG10172inacutestroketreatment(TOAST)criteria.Stroke.32(5):1091-1096,2001.

122. MatcharDB,KulasingamSL,McCroryDC,PatwardhanMD,RutschmannOT,SamsaGP,SchemechelDE.UseofpositionemissiontomographyandotherneuroimagingtechniquesinthediagnosisandmanagementofAlzheimer'sdiseaseanddementia.TechnologyAssessmentTaskOrderNumber7(PreparedbyDukeEvidence-basePracticeCenter,ContractNo.290-97-0014).AgencyforHealthcareResearchandQuality,RockvilleMD,December2001.Availableathttp://www.cms.hhs.gov/coverage/download/8b3-ww3.pdf.

123. MatcharDB,MyersER,BarberMW,CouchmanGM,DattaS,Gustilo-AshbyT,KolimagJT,McCrocryDC.Managementofuterinefibroids.EvidenceReport/TechnologyAssessmentNumber34.(PreparedbyDukeEvidence-basedPracticeCenterunderContractNo.290-97-0014).AHRQPublicationNo.01-E051..AgencyforHealthcareResearchandQuality,Rockville,MD,January2001.Availableathttp://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.47755(volumeI)andhttp://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.48739(volumeII).

124. McCroryDC,SamsaGP,HamiltonBB,GovertJA,MatcharDB,Goslin,RE,KolimagaJT.Treatmentofpulmonarydiseasefollowingcervicalspinalcordinjury.EvidenceReport/TechnologyAssessmentNumber27.(PreparedbytheDukeEvidence-basedPracticeCenterunderContractNo.290-97-0014).AHRQPublicationNo.01-E014.AgencyforHealthcareResearchandQuality,Rockville,MD,June2001.Availableathttp://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.38295.

125. SamsaGP,MatcharDB.Haverandomizedcontrolledtrialsofneuroprotectivedrugsbeenunderpowered?Anillustrationofthreestatisticalprinciples.Stroke.32(3):669-674,2001.

126. LeePY,MatcharDB,ClementsDA,HuberJ,HamiltonJD,PetersonED.Economicanalysisofinfluenzavaccinationandantiviraltreatmentforhealthyworkingadults.AnnalsofInternalMedicine.137(4):225-231,2002.

127. MatcharDB,SamsaGP,CohenSJ,OddoneEZ,JurgelskiAE.Improvingthequalityofanticoagulationofpatientswithatrialfibrillationinmanagedcareorganizations:resultsoftheManagingAnticoagulationServicesTrial.AmericanJournalofMedicine.113(1):42-51,2002.

128. McCroryDC,KlassenP,RutschmannOT,ColadonatoJA,YancyWSJr,ReddanDN,GrayRN,OwenWF,ShurrEG,MatcharDB.AppropriatepatientpreparationforRenalReplacementTherapy.EvidenceReport/FinalReport.(PreparedbytheDukeEvidence-basedPracticeCenterandDukeCenterforClinicalHealthPolicyResearch).Rockville,MD:RenalPhysiciansAssociation;April2002.Availableathttp://www.renalmd.org/publications/downloads/FinalEvReportandTables.pdf.

129. MyersER,BarberMD,Gustilo-AshbyT,CouchmanG,MatcharDB,McCroryDC.Managementofuterineleiomyomata:Whatdowereallyknow?ObstetricsandGynecology.100(1):8-17,2002.

130. MyersER,BlumrickR,ChristianAL,DattaS,GrayRN,KolimagaJT,LivingstonE,LukesA,MatcharDB,McCroryDC.Managementofprolongedpregnancy.EvidenceReport/TechnologyAssessmentNumber53.(PreparedbyDukeEvidence-basedPracticeCenterunderContractNo.290-97-0014).

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AHRQPublicationNo.02-E012.AgencyforHealthcareResearchandQuality,Rockville,MD,March2002.Availableathttp://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.102647.

131. RutschmannOT,MatcharDB.Usefulnessofpositronemissiontomographyinevaluatingdementia.JAMA-JournaloftheAmericanMedicalAssociation.287(8):985-986,2002.

132. RutschmannOT,McCroryDC,MatcharDB,ImmunizationPanelMultipleS.ImmunizationandMS-asummaryofpublishedevidenceandrecommendations.Neurology.59(12):1837-1843,2002.

133. SamsaG,OddoneEZ,HornerR,DaleyJ,HendersonW,MatcharDB.Towhatextentshouldqualityofcaredecisionsbebasedonhealthoutcomesdata?Applicationtocarotidendarterectomy.Stroke.33(12):2944-2949,2002.

134. SamsaGP,GovertJ,MatcharDB,McCroryDC.Useofdatafromnonrandomizedtrialdesignsinevidencereports:Anapplicationtotreatmentofpulmonarydiseasefollowingspinalcordinjury.JournalofRehabilitationResearchandDevelopment.39(1):41-52,2002.

135. SamsaGP,MatcharDB,PhillipsDL,McGrannJ.Whichapproachtoanticoagulationmanagementisbest?Illustrationofaninteractivemathematicalmodeltosupportinformeddecisionmaking.JournalofThrombosisandThrombolysis.14(2):103-111,2002.

136. SamsaGP,MatcharDB,WilliamsGR,LevyDE,participantsS.Cost-effectivenessofancrodtreatmentofacuteischaemicstroke:Resultsfromthestroketreatmentwithancrodtrial(STAT).JournalofEvaluationinClinicalPractice.8(1):61-70,2002.

137. ShafferDN,DattaSK,MatcharDB.Cost-effectivenessofabbreviatedregimensforhelicobactorpylorieradicationinpepticulcerdisease.JournalofClinicalOutcomesManagement.9:71-78,2002.

138. WhellanDJ,CohenEJ,MatcharDB,CaliffRM.Diseasemanagementinhealthcareorganizations:Resultsofin-depthinterviewswithdiseasemanagementdecisionmakers.AmericanJournalofManagedCare.8(7):633-641,2002.

139. AbernethyAP,SamsaGP,MatcharDB.Aclinicaldecisionandeconomicanalysismodelofcancerpainmanagement.AmericanJournalofManagedCare.9(10):651-664,2003.

140. BianJ,OddoneEZ,SamsaGP,LipscombJ,MatcharDB.Racialdifferencesinsurvivalpostcerebralinfarctionamongtheelderly.Neurology.60(2):285-290,2003.

141. Colon-EmericCS,DattaSK,MatcharDB.Aneconomicanalysisofexternalhipprotectoruseinambulatorynursingfacilityresidents.AgeandAgeing.32(1):47-52,2003.

142. GoldsteinLB,MatcharDB,Hoff-LindquistJ,SamsaGP,HornerRD.Vastrokestudy-neurologistcareisassociatedwithincreasedtestingbutimprovedoutcomes.Neurology.61(6):792-7962003.

143. GoldsteinLB,MatcharDB,Hoff-LindquistJ,SamsaGP,HornerRD.Veteransadministrationacutestroke(VAST)study-lackofrace/ethnic-baseddifferencesinutilizationofstroke-relatedproceduresorservices.Stroke.34(4):999-1003,2003.

144. HarpoleLH,SamsaGP,JurgelskiAE,ShipleyJL,BernsteinA,MatcharDB.Headachemanagementprogramimprovesoutcomeforchronicheadache.Headache.43(7):715-724,2003.

145. HornerRD,SwansonJW,BosworthHB,MatcharDB,TeamVS.Effectsofraceandpovertyontheprocessandoutcomeofinpatientrehabilitationservicesamongstrokepatients.Stroke.34(4):1027-1031,2003.

146. KulasingamSL,SamsaGP,ZarinDA,RutschmannOT,PatwardhanMB,McCroryDC,SchmechelDE,MatcharDB.WhenshouldfunctionalneuroimagingtechniquesbeusedinthediagnosisandmanagementofAlzheimer'sdementia?Adecisionanalysis.ValueinHealth.6(5):542-550,2003.

147. MatcharDB.Doanticoagulationmanagementservicesimprovecare?ImplicationsoftheManagingAnticoagulationServicesTrial.CardiacElectrophysiologyReview.7:379-381,2003.

148. MatcharDB.Healthpolicyinstroke:translatingwhatweknowintowhatwedo.Stroke.34(2):370-371,2003.

149. MatcharDB,PatwardhanMB,SamsaGP.Makingevidence-basedpracticeimprovementmorethanacomfortingsentiment.AmericanJournalofMedicine.115(5):407-409,2003.

150. ParmigianiG,AshihHW,SamsaGR,DuncanPW,LaiSM,MatcharDB.Cross-calibrationofstrokedisabilitymeasures:Bayesiananalysisoflongitudinalordinalcategoricaldatausingnegativedependence.JournaloftheAmericanStatisticalAssociation.98(462):273-281,2003.

151. BushnellCD,MatcharDB.Pharmacoeconomicsofatrialfibrillationandstrokeprevention.AmericanJournalofManagedCare.10:S66-S71,2004.

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152. DodickD,LiptonRB,MartinV,PapademetriouV,RosamondW,MaassenVanDenBrinkA,LoutfiH,WelchKM,GoadsbyPJ,HahnS,HutchinsonS,MatcharD,SilbersteinS,SmithTR,PurdyRA,SaiersJ,TriptanCardiovascularSafetyE.Consensusstatement:Cardiovascularsafetyprofileoftriptans(5-ht1b/1dagonists)intheacutetreatmentofmigraine.Headache.44(5):414-425,2004.

153. GoldsteinLB,MatcharDB,Hoff-LindquistJ,SamsaGP,HornerRD.VeteransAdministrationAcuteStroke(VASt)Study:Neurologistcareisassociatedwithincreasedtestingbutimprovedoutcomes.Neurology.62:1914-1915,2004.

154. GoldsteinLB,SamsaGP,MatcharDB,HornerRD.Charlsonindexcomorbidityadjustmentforischemicstrokeoutcomestudies.Stroke.35(8):1941-1945,2004.

155. JamesA,MatcharDB,MyersER.TestingforvonWillebranddiseaseinwomenwithmenorrhagia:Asystematicreview.ObstetricsandGynecology.104(2):381-388,2004.

156. MatcharDB.Whatcanmodelsteachusaboutstroketreatment?Sortingoutthemissingbits.Stroke.35(6):1497-1498,2004.

157. MatcharDB,KulasingamSL,HavrileskyL,MannLO,MyersER,McCroryDC,PatwardhanM,ProsnitzR.Positronemissiontestingforsixcancers(brain,cervical,smallcelllung,ovarian,pancreaticandtesticular).(PreparedbytheDukeUniversityunderContractNo.290-02-0025).TaskOrderNo.0.Rockville,MD:AgencyforHealthCarePolicyandResearch.Availableathttp://www.cms.hhs.gov/mcd/index_list.asp?list_type=tech.March2004.

158. McCroryDC,PompeiiLA,SkeenMB,MoonSD,GrayRN,KolimagaJT,MatcharDB.Criteriatodeterminedisabilityrelatedtomultiplesclerosis.EvidenceReport/TechnologyAssessmentNumber100.(PreparedbyDukeEvidence-basedPracticeCenterundercontractno.290-02-0025).AHRQPublicationNo.04-E019-2.Rockville,MD:AgencyforHealthcareResearchandQuality.May2004.

159. OrlandoLA,KulasingamSL,MatcharDB.Meta-analysis:Thedetectionofpancreaticmalignancywithpositronemissiontomography.AlimentaryPharmacology&Therapeutics.20(10):1063-1070,2004.

160. OrlandoLA,MatcharDB.Whentostressovertriptans:AMarkovanalysisofcardiovascularriskinmigrainetreatment.Headache.44(7):652-660,2004.

161. PatwardhanMB,McCroryDC,MatcharDB,SamsaGP,RutschmannOT.Alzheimerdisease:operatingcharacteristicsofPET-ameta-analysis.Radiology.231(1):73-80,2004.

162. RuddAG,MatcharDB.Healthpolicyandoutcomeresearchinstroke.Stroke.35(2):397-400,2004.163. SamsaGP,MatcharDB.Howstrongistherelationshipbetweenfunctionalstatusandqualityoflifeamong

personswithstroke?JournalofRehabilitationResearchandDevelopment.41(3A):279-282,2004.164. SamsaGP,MatcharDB,DolorRJ,WiklundI,HednerE,WygantG,HauchO,MarpleCB,EdwardsR.Anew

instrumentformeasuringanticoagulation-relatedqualityoflife:developmentandpreliminaryvalidation.HealthandQualityofLifeOutcomes.2:22.Availableathttp://www.hqlo.com/content/pdf/1477-7525-2-22.pdf.2004

165. KulasingamSL,MatcharDB,DonaldSchmechelD.P2-350Costassociatedwithincreasingseverityofdementia–Areviewoftheliterature.NeurobiologyofAging.01/200425.

166. HarpoleLH,SamsaGP,MatcharDB,SilbersteinSD,BlumenfeldA,JurgelskiAE.Burdenofillnessandsatisfactionwithcareamongpatientswithheadacheseeninaprimarycaresetting.Headache.45(8):1048-1055,2005.

167. HavrileskyLJ,KulasingamSL,MatcharDB,MyersER.FDG-PETformanagementofcervicalandovariancancer.GynecologicOncology.97(1):183-191,2005.

168. LiaoL,Sarria-SantameraA,MatcharDB,HuntingtonA,LinS,WhellanDJ,KongDF.Meta-analysisofsurvivalandreliefofanginapectorisaftertransmyocardialrevascularization.AmericanJournalofCardiology.95(10):1243-1245,2005.

169. MatcharDB,JacobsonAK,EdsonRG,LavoriPW,AnsellJE,EzekowitzMD,RicklesF,FioreL,BoardmanK,PhibbsC,FihnSD,VertreesJE,DolorR.Theimpactofpatientself-testingofprothrombintimeformanaginganticoagulation:RationaleanddesignofVAcooperativestudy#481-TheHomeINRStudy(THINRS).JournalofThrombosisandThrombolysis.19(3):163-172,2005.

170. MatcharDB,RosenbergJH,CarterS.Guidelinesforanewerainthecareofpatientswithepilepsy:firststepsinrespondingtothechallenge.PostgraduateMedicine.118:18-21,2005.

171. MatcharDB,RuddAG.Healthpolicyandoutcomesresearch2004.Stroke.36(2):225-227,2005.

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172. MatcharDB,SamsaGP.Howcanmodelingbestcontributetotheassessmentofsecondarystrokepreventionstrategies?AmericanJournalofMedicine.118(2):198-199,2005.

173. MatcharDB,SamsaGP,LiuS.Cost-effectivenessofantiplateletagentsinsecondarystrokeprevention:Thelimitsofcertainty.ValueinHealth.8(5):572-580,2005.

174. MatcharDB,Westermann-ClarkEV,McCroryDC,PatwardhanM,SamsaG,KulasingamS,MyersE,Sarria-SantameraA,LeeA,GrayR,LiuK.Disseminationofevidence-basedpracticecenterreports.AnnalsofInternalMedicine.142(12):1120-1125,2005.

175. OrlandoLA,MatcharDB.Chronickidneydisease:Relationshipofnephrologistinvolvementanddiseasecourse.JournalofInvestigativeMedicine.53(1):340,2005.

176. PatwardhanMB,MatcharDB,SamsaGP,McCroryDC,WilliamsRG,LiTT.Costofmultiplesclerosisbylevelofdisability:Areviewofliterature.MultipleSclerosis.11(2):232-239,2005.

177. SamsaGP,MatcharDB,HarnettJ,WilsonJ.Acost-minimizationanalysiscomparingazithromycin-basedandlevofloxacin-basedprotocolsforthetreatmentofpatientshospitalizedwithcommunity-acquiredpneumonia-resultsfromtheCAP-intrial.Chest.128(5):3246-3254,2005.

178. AminMS,MatcharDB,WoodMA,EllenbogenKA.Managementofrecalledpacemakersandimplantablecardioverter-defibrillators-adecisionanalysismodel.JAMA-JournaloftheAmericanMedicalAssociation.296(4):412-420,2006.

179. BianJ,DowWH,MatcharDB.MedicareHMOpenetrationandmortalityoutcomesofischemicstroke.AmericanJournalofManagedCare.12(1):58-64,2006.

180. KulasingamSL,SamsaGP,MatcharDB.Linkingdementiaresearchtopolicy:anexampleusingfluorodeoxyglucosepositronemissiontomographyforthediagnosisofAlzheimer'sdementiaandmildcognitiveimpairment.AmericanJournalofAlzheimersDiseaseandOtherDementia.21(2):73-8,2006.

181. MatcharDB,PatwardhanMB,SamsaGP,HaleyWE.Facilitatedprocessimprovement:AnapproachtotheseamlesslinkagebetweenevidenceandpracticeinCKD.AmericanJournalofKidneyDiseases.47(3):528-538,2006.

182. PatwardhanMB,SamsaGP,LiptonRB,MatcharDB.Changingphysicianknowledge,attitudes,andbeliefsaboutmigraine:Evaluationofaneweducationalintervention.Headache.46(5):732-741,2006.

183. OrlandoLA,OwenWF,MatcharDB:Relationshipbetweennephrologistcareandprogressionofchronickidneydisease.NorthCarolinaMedicalJournal.68(1):9-16,2007.

184. PatwardhanMB,Sarria-SantameraA,MatcharDB.Improvingtheprocessofdevelopingtechnicalreportsforhealthcaredecisionmakers:UsingtheTheoryofConstraintsintheEvidence-basedPracticeCenters.InternationalJournalofTechnologyAssessmentinHealthCare.22(1):26-32,2006.

185. Sarria-SantameraA,MatcharDB,Westermann-ClarkE,PatwardhanMB.Evidence-basedpracticecenternetworkandhealthtechnologyassessmentintheUnitedStates:Bridgingtheculturalgap.InternationalJournalofTechnologyAssessmentinHealthCare.22(1):33-38,2006.

186. EisensteinEL,AnstromKJ,KongDF,ShawLK,TuttleRH,MarkDB,KramerJM,HarringtonRA,MatcharDB,KandzariDE,PetersonED,SchulmanKA,CaliffRM.Clopidogreluseandlong-termclinicaloutcomesafterdrug-elutingstentimplantation.JAMA-JournaloftheAmericanMedicalAssociation.297(2):159-168,2007.

187. MatcharDB,McCroryDC,OrlandoLA,PatelMR,PatelUD,PatwardhanMB,PowersB,SamsaGP,GrayRN.Comparativeeffectivenessofangiotensin-convertingenzymeinhibitors(ACEIs)andangiotensinIIreceptorantagonists(ARBs)fortreatingessentialhypertension.ComparativeEffectivenessReviewNo.10.(PreparedbyDukeEvidence-basedPracticeCenterunderContractNo.290-02-0025.)Rockville,MD:AgencyforHealthcareResearchandQuality.Availableat:www.effectivehealthcare.ahrq.gov/reports/final.cfm.November2007.

188. MatcharDB,ThakurM.Isgenetictestingforcytochromep450polymorphismsreadyforimplementation?AmericanFamilyPhysician.76(3):348-+,2007.

189. MatcharDB.ThakurME.GrossmanI.McCroryDC.OrlandoLA.SteffensDC.GoldsteinDB.ClineKE.GrayRN.TestingforcytochromeP450polymorphismsinadultswithnon-psychoticdepressiontreatedwithselectiveserotoninreuptakeinhibitors(SSRIs).EvidenceReport/TechnologyAssessment.(146):1-77,2007.

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190. PatelMR,HurwitzLM,OrlandoL,McCroryDC,SandersGD,MatcharDB,MarkD.Noninvasiveimagingforcoronaryarterydisease:AtechnologyassessmentfortheMedicareCoverageAdvisoryCommission.AmericanHeartJournal.153(2):161-174,2007.

191. PatwardhanMB,SamsaGP,MatcharDB,HaleyWE.Advancedchronickidneydiseasepracticepatternsamongnephrologistsandnon-nephrologists:Adatabaseanalysis.ClinicalJournaloftheAmericanSocietyofNephrology.2(2):277-283,2007.

192. PatwardhanMB,SamsaGP,MatcharDB,HaleyWE.Non-nephrologistandnephrologistperspectivesonimplementingachronickidneydiseaseguideline.JournalforHealthcareQuality.Inpress(WebExclusive.Vol.29,No.6,pp.W6-3–W6-17.November/December2007).

193. ThakurM,GrossmanI,McCroryDC,OrlandoLA,SteffensDC,ClineKE,GrayRN,FarmerJ,DeJesusG,O'BrienC,SamsaG,GoldsteinDB,MatcharDB.Reviewofevidenceforgenetictestingforcyp450polymorphismsinmanagementofpatientswithnonpsychoticdepressionwithselectiveserotoninreuptakeinhibitors.GeneticsinMedicine.9(12):826-835,2007.

194. AnstromKJ,KongDF,ShawLK,CaliffRM,KramerJM,PetersonED,RaoSV,MatcharDB,MarkDB,HarringtonRA,EisensteinEL.Long-termclinicaloutcomesfollowingcoronarystenting.ArchivesofInternalMedicine.168(15):1647-1655,2008.

195. DornSD,MatcharDB.Cost-effectivenessanalysisofstrategiesfordiagnosingceliacdisease.DigestiveDiseasesandSciences.53(3):680-688,2008.

196. KonstanceRP,EisensteinEL,AnstromKJ,ShawLK,CaliffRM,HarringtonRA,MatcharDB,SchulmanKA,KongDF.Outcomesofsecondrevascularizationproceduresafterstentimplantation.JournalofMedicalSystems.32(2):177-186,2008.

197. KrumholzHM,KeenanPS,BrushJE,BufalinoVJ,ChernewME,EpsteinAJ,HeidenreichPA,HoV,MasoudiFA,MatcharDB,NormandSLT,RumsfeldJS,SchuurJD,SmithSC,SpertusJA,WalshMN.Standardsformeasuresusedforpublicreportingofefficiencyinhealthcare-AscientificstatementfromtheAmericanHeartAssociationInterdisciplinaryCouncilonQualityofCareandOutcomesResearchandtheAmericanCollegeofCardiologyFoundation.JournaloftheAmericanCollegeofCardiology.52(18):1518-1526,2008.

198. MatcharDB,HarpoleL,SamsaGP,JurgelskiA,LiptonRB,SilbersteinSD,YoungW,KoriS,BlumenfeldA.Theheadachemanagementtrial:Arandomizedstudyofcoordinatedcare.Headache.48(9):1294-1310,2008.

199. MatcharDB,MarkDB.Strategiesforincorporatingresourceallocationandeconomicconsiderations:AmericanCollegeofChestPhysicansevidence-basedclinicalpracticeguidelines.Chest.133(6):132S-140S,2008.

200. MatcharDB,McCroryDC,OrlandoLA,PatelMR,PatelUD,PatwardhanMB,PowersB,SamsaGP,GrayRN.Systematicreview:Comparativeeffectivenessofangiotensin-convertingenzymeinhibitorsandangiotensinIIreceptorblockersfortreatingessentialhypertension.AnnalsofInternalMedicine.148(1):16-29,2008.

201. MyersER,McCroryDC,MillsAA,PriceTM,SwamyGK,TantibhedhyangkulJ,WuJM,MatcharDB.Effectivenessofassistedreproductivetechnology(ART).EvidRepTechnolAssess(FullRep).(167):1-195,2008.

202. PatwardhanMB,MatcharDB,SamsaGP,HaleyWE.Opportunitiesforimprovingmanagementofadvancedchronickidneydisease.AmericanJournalofMedicalQuality.23(3):184-192,2008.

203. PatwardhanMB,MatcharDB,SamsaGP,HaleyWE.Utilityoftheadvancedchronickidneydiseasepatientmanagementtools:Casestudies.AmericanJournalofMedicalQuality.23(2):105-114,2008.

204. DolorRJ,YancyWS,OwenWF,MatcharDB,SamsaGP,PollakKI,LinPH,ArdJD,PrempehM,McGuireHL,BatchBC,FanW,SvetkeyLP.Hypertensionimprovementproject(HIP):Studyprotocolandimplementationchallenges.Trials.10:13,2009.PMID19245692.

205. DouglasPS,BrennanJM,AnstromKJ,SedrakyanA,EisensteinEL,HaqueG,DaiD,KongDF,HammillB,CurtisL,MatcharD,BrindisR,PetersonED.Clinicaleffectivenessofcoronarystentsinelderlypersonsresultsfrom262,700MedicarepatientsintheAmericanCollegeofCardiology-NationalCardiovascularDataRegistry.JournaloftheAmericanCollegeofCardiology.53(18):1629-1641,2009.

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206. PatwardhanMB,KawamotoK,LobachD,PatelUD,MatcharDB.Recommendationsforaclinicaldecisionsupportforthemanagementofindividualswithchronickidneydisease.ClinicalJournaloftheAmericanSocietyofNephrology.4(2):273-283,2009.

207. SvetkeyLP,PollakKI,YancyWS,Jr.,DolorRJ,BatchBC,SamsaG,MatcharDB,LinPH.Hypertensionimprovementproject.Randomizedtrialofqualityimprovementforphysiciansandlifestylemodificationforpatients.Hypertension.54(6):1226-1233,2009.

208. FrickKD,KymesSM,LeePP,MatcharDB,PezzulloML,ReinDB,TaylorHR;Vancouvereconomicburdenofvisionlossgroup.Thecostofvisualimpairment:Purposes,perspectives,andguidance.InvestigativeOphthalmology&VisualScience.51:1801-1805,2010.

209. DolorRJ,RuybalidRL,UyedaL,EdsonRG,PhibbsC,VertreesJE,ShihMC,JacobsonAK,MatcharDB;Anevaluationofpatientself-testingcompetencyofprothrombintimeformanaginganticoagulation:PrerandomizationresultsofVAcooperativestudy#481-TheHomeINRStudy(THINRS).JournalofThrombosisandThrombolysis.30(3):263-275,2010.

210. PatelMR,GreinerMA,DiMartinoLD,SchulmanKA,DuncanPW,MatcharDB,CurtisLH.GeographicvariationincarotidrevascularizationamongMedicarebeneficiaries,2003-2006.ArchivesofInternalMedicine.17(14):1218-1225,2010.

211. MatcharDB,JacobsonA,DolorRJ,EdsonRG,UyedaL,PhibbsCS,VertreesJE,ShihMC,HolodniyM,LavoriP.Effectofhometestingofinternationalnormalizedratioonclinicalevents.NewEnglandJournalofMedicine.363(17):1608-1620,2010.

212. MercaldiCJ,CiarametaroM,HahnB,ChalisseryG,ReynoldsMW,SanderSD,SamsaGP,MatcharDB;CostefficiencyofanticoagulationwithwarfarintopreventstrokeinMedicarebeneficiarieswithnon-valvularatrialfibrillation.Stroke.42(1):112-8,2010.

213. CurtisL,DuncanPW,MatcharDB,GreinerMA,PatelMR,SchulmanKA;GeographicvariationandtrendsincarotidimagingamongMedicarebeneficiaries,2001-2006.Circulation:CardiovascularQualityandOutcomes.3(6):599-606,2010.

214. RogerVL,GoAS,Lloyd-JonesDM,AdamsRJ,BerryJD,BrownTM,CarnethonMR,DaiS,deSimoneG,FordES,FoxCS,FullertonHJ,GillespieC,GreenlundKJ,HailpernSM,HeitJA,HoPM,HowardVJ,KisselaBM,KittnerSJ,LacklandDT,LichtmanJH,LisabethLD,MakucDM,MarcusGM,MarelliA,MatcharDB,McDermottMM,MeigsJB,MoyCS,MozaffarianD,MussolinoME,NicholG,PaynterNP,RosamondWD,SorliePD,StaffordRS,TuranTN,TurnerMB,WongND,Wylie-RosettJ;HeartDiseaseandStrokeStatistics--2011Update:AReportFromtheAmericanHeartAssociation.Circulation.1;123(4):e18-e209,2011.

215. OrlandoLA,BelascoEJ,PatelUD,MatcharDB;TheChronicKidneyDiseaseModel:Ageneralpurposemodelofdiseaseprogressionandtreatment.BMCMedicalInformaticsandDecisionMaking.11(1):41,2011.

216. CarrascoLR,LeeVJ,ChenMI,MatcharDB,ThompsonJP,CookAR;Strategiesforantiviralstockpilingforfutureinfluenzapandemics:aglobalepidemic-economicperspective.JournalofRoyalSocietyInterface.8(62):1307-13,2011.

217. SetiaM,IslamAM,ThompsonJP,MatcharDB;Stakeholders’sperspectiveonissuesandchallengesassociatedwithcareandtreatmentofaging-relatedcognitiveimpairmentdisordersinSingapore.InternationalPsychogeriatricAssociation.1-12,2011.

218. AtkinsD,ChangS,GartlehnerG,BuckleyDI,WhitlockEP,BerlinerE,MatcharDB.Assessingapplicabilitywhencomparingmedicalinterventions:AgencyforHealthcareResearchandQualityandtheEffectiveHealthCareProgram.JournalofClinicalEpidemiology.64(11):1198-207,2011.

219. RogerVL,GoAS,Lloyd-JonesDM,BenjaminEJ,BerryJD,BordenWB,BravataDM,DaiS,FordES,FoxCS,FullertonHJ,GillespieC,HailpernSM,HeitJA,HowardVJ,KisselaBM,KittnerSJ,LacklandDT,LichtmanJH,LisabethLD,MakucDM,MarcusGM,MarelliA,MatcharDB,MoyCS,MozaffarianD,MussolinoME,NicholG,PaynterNP,SolimanEZ,SorliePD,SotoodehniaN,TuranTN,ViraniSS,WongND,WooD,TurnerMB;AmericanHeartAssociationStatisticsCommitteeandStrokeStatisticsSubcommittee;Executivesummary:heartdiseaseandstrokestatistics--2012update:areportfromtheAmericanHeartAssociation.Circulation.125(1):188-97,2011.

220. HeneghanC,WardA,PereraR,BankheadC,FullerA,StevensR,BradfordK,TyndelS,Alonso-CoelloP,AnsellJ,BeythR,BernardoA,ChristensenTD,CromheeckeME,EdsonRG,FitzmauriceD,Gadisseur

15

AP,Garcia-AlaminoJM,GardinerC,HasenkamJM,JacobsonA,KaatzS,KamaliF,KhanTI,KnightE,KortkeH,LeviM,MatcharD,Menendez-JandulaB,RakovacI,SchaeferC,SiebenhoferA,SoutoJC,SunderjiR,GinK,ShalanskyK,VollerH,WagerO,ZittermannA.Self-monitoringoforalanticoagulation:Systematicreviewandmeta-analysisofindividualpatientdata.Lancet.379(9813):322-34.2012.

221. SmetanaGW,UmscheidCA,ChangS,MatcharDB.Methodsguideforauthorsofsystematicreviewsofmedicaltests:acollaborationbetweentheAgencyforHealthcareResearchandQuality(AHRQ)andtheJournalofGeneralInternalMedicine.JournalofGeneralInternalMedicine.27(1):S1-3.2012.

222. MatcharDB.Introductiontothemethodsguideformedicaltestreviews.JournalofGeneralInternalMedicine.27(1):4–10.2012.

223. SantaguidaPL,RileyCM,MatcharDB.Assessingriskofbiasasadomainofqualityinmedicalteststudies.JournalofGeneralInternalMedicine.27(1):S33-8.2012.

224. HartmannKE,MatcharDB,BassEB.Assessingapplicabilityofmedicalteststudiesinsystematicreviews.JournalofGeneralInternalMedicine.27(1):S39-46.2012.

225. SinghS,ChangSM,MatcharDB,BassEB.Gradingabodyofevidenceondiagnostictests.JournalofGeneralInternalMedicine.27Suppl1:S47-55,2012.

226. JonasDE,WiltTJ,TaylorBC,WilkinsTM,MatcharDB.Challengesinandprinciplesforconductingsystematicreviewsofgenetictestsusedaspredictiveindicators.JournalofGeneralInternalMedicine.27(1):S83-93.2012.

227. WhitsonHE,MalhotraR,ChanA,MatcharDB,OstbyeT.Comorbidvisualandcognitiveimpairment:Relationshiptodisabilitystatusandself-ratedhealthamongolderSingaporeans.Asia-PacificJournalofPublicHealth.2012Apr24;26(3):310-319.

228. MalhotraC,MalhotraR,ØstbyeT,MatcharD,ChanA.Depressivesymptomsamonginformalcaregiversofolderadults:insightsfromtheSingaporeSurveyonInformalCaregiving.InternationalPsychogeriatrics.2012Aug;24(8):1335-46.doi:10.1017/S1041610212000324.Epub2012Mar22.

229. RileyCM,HaalandB,LoveS,MatcharDB.ExpertestimatesofcaregiverhoursforolderSingaporeanswithdementia.AustralasianJournalOnAgeing.31(4):255-9.2012.

230. ThompsonJP,RileyCM,EberleinRL,MatcharDB.FuturelivingarrangementsofSingaporeanswithage-relateddementia.InternationalPsychogeriatratrics.1:1-8.2012.

231. GardenerH,etal.Statisticalanalysisoftheprimaryoutcomeinacutestroketrials.Stroke.43(4):1171-8.2012.

232. LeesKR,BathPM,SchellingerPD,KerrDM,FultonR,HackeW,MatcharD,SehraR,ToniD.Contemporaryoutcomemeasuresinacutestrokeresearch:Choiceofprimaryoutcomemeasure.Stroke.43(4):1163-70.2012.

233. RogerVL,GoAS,Lloyd-JonesDM,BenjaminEJ,BerryJD,BordenWB,BravataDM,DaiS,FordES,FoxCS,FullertonHJ,GillespieC,HailpernSM,HeitJA,HowardVJ,KisselaBM,KittnerSJ,LacklandDT,LichtmanJH,LisabethLD,MakucDM,MarcusGM,MarelliA,MatcharDB,MoyCS,MozaffarianD,MussolinoME,NicholG,PaynterNP,SolimanEZ,SorliePD,SotoodehniaN,TuranTN,ViraniSS,WongND,WooD,TurnerMB.Executivesummary:Heartdiseaseandstrokestatistics—2012update:AreportfromtheAmericanHeartAssociation.Circulation.5;125(22):e1001.2012.

234. FeiG,MachinD,ChowKY,SimYF,DuffeySW,MatcharDB,GohCH,ChiaKS.AssessingriskofbreastcancerinanethnicallySoutheastAsiapopulation(resultsofamultipleethnicgroupsstudy).BMCCancer.12:529.2012.

235. AnsahJP,MatcharDB,LoveS,MalhotraR,DoYK,ChanA,EberleinR.Simulatingtheimpactoflong-termcarepolicyonfamilyeldercarehours.HealthServicesResearch.48(2):773-91.2013.

236. MalhotraC,ChanA,MatcharDB,SeowD,ChuoA,DoYK.DiagnosticperformanceofshortportablementalstatusquestionnaireforscreeningdementiaamongpatientsattendingcognitiveassessmentclinicsinSingapore.Annals–AcademyofMedicineSingapore.42(7):315-9.2013.

237. ChinCT,MellstromC,ChuaTS,MatcharDB.Lifetimecost-effectivenessanalysisofticagrelorinpatientswithacutecoronarysyndromesbasedonthePLATOtrial:aSingaporehealthcareperspective.SingaporeMedJ2013Mar:54(3):169-175doi:10.11622/smedj.2013045.

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238. ThompsonJP,MalhotraR,LoveSR,ØstbyeT,ChanA,MatcharDB.ProjectingthenumberofolderSingaporeanswithActivityofDailyLivinglimitationsrequiringhumanassistancethrough2030.Annals–AcademyofMedicineSingapore.43(1):51-6.2014.

239. ZalesakM,SiuK,FrancisK,YuC,AlvrtsyanH,RaoY,WalkerD,SanderS,MiyasatoG,MatcharD,SanchezH.Higherpersistenceinnewlydiagnosednonvalvularatrialfibrillationpatientstreatedwithdabigatranversuswarfarin.Circulation:CardiovascularQualityOutcomes.2013Sep1;6(5):567-74.doi:10.1161/CIRCOUTCOMES.113.000192.Epub2013Aug6.Erratumin:Circulation:CardiovascularQualityOutcomes.2013Nov;6(6):e59.

240. MalhotraR,CheiCL,OstbyeT,ChanA,MatcharDB.Olderpersonbehavioralandpsychologicalsymptoms(BPS)andfunctionallimitationsmediatetheassociationbetweenolderpersoncognitiveimpairmentanddepressivesymptomsinthecaregiver.ArchivesofGerontologyandGeriatrics.2013Oct24.pii:S0167-4943(13)00162-3.doi:10.1016/j.archger.2013.10.004.

241. AnsahJP,EberleinRL,LoveSR,ThompsonJP,MalhotraR,MatcharDB.Implicationsoflong-termcarecapacityresponsepoliciesforanagingpopulation:Asimulationanalysis.HealthPolicy.2014Jan07.pii:S0168-8510(14)00009-8.doi:10.1016/j.healthpol.2014.01.006.

242. MatcharDB,LoveSR,JacobsonAK,EdsonR,UyedaL,PhibbsCS,DolorRJ.Theimpactoffrequencyofpatientself-testingofprothrombintimeontimeintargetrangewithinVACooperativeStudy#481:TheHomeINRStudy(THINRS),arandomized,controlledtrial.JThrombThrombolysis.2014Sep11.Doi:10.1007/s11239-014-1128-8.

243. CheiCL,RamanP,YinZX,ShiXM,ZengY,MatcharDB.VitaminDlevelsandcognitioninelderlyadultsinChina.JournaloftheAmericanGeriatricsSociety.2014Oct3.doi:10.1111/jgs.13082.

244. PokorneySD,ZhouK,MatcharDB,LoveS,ZeitlerE,LewisR,PicciniJP.OptimalmanagementofRiataleadswithnoknownelectricalabnormalitiesorexternalization:Adecisionanalysis.JournalofCardiovascularElectrophysiol.2014Oct13.doi:10.1111/jce.12563.

245. MalhotraR,HaalandBA,CheiCL,ChanA,MalhotraC,MatcharDB.Presenceofandcorrectionforinterviewererroronaninstrumentassessingcognitivefunctionofolderadults.Geriatrics&GerontologyInternational.2015;15(3):372-380.

246. ChanA,MatcharDB,TsaoMA,HardingS,ChiuCT,TayB,RamanP,PietrylaZ,KleinMK,HaldaneVE.Self-CareforOlderPeople(SCOPE):Aclusterrandomizedcontrolledtrialofself-caretrainingandhealthoutcomesinlow-incomeelderlyinSingapore.ContemporaryClinicTrials.2015Jan10.pii:S1551-7144(15)00002-6.doi:10.1016/j.cct.2015.01.001.

247. LvYB,YinZX,CheiCL,QianHZ,KrausVB,ZhangJ,BrasherMS,ShiXM,MatcharDB,ZengY.Low-densitylipoproteincholesterolwasinverselyassociatedwith3-yearall-causemortalityamongChineseoldestold:DatafromtheChineselongitudinalhealthylongevitysurvey.Atherosclerosis.2015Jan14;239(1):137-142.doi:10.1016/j.atherosclerosis.2015.01.002.

248. MozaffarianD,BenjaminEJ,GoAS,ArnettDK,BlahaMJ,CushmanM,deFerrantiS,DesprésJP,FullertonHJ,HowardVJ,HuffmanMD,JuddSE,KisselaBM,LacklandDT,LichtmanJH,LisabethLD,LiuS,cMackeyRH,MatcharDB,McGuireDK,MohlerER3rd,MoyCS,MuntnerP,MussolinoME,NasirK,NeumarRW,NicholG,PalaniappanL,PandeyDK,ReevesMJ,RodriguezCJ,SorliePD,SteinJ,TowfighiA,TuranTN,ViraniSS,WilleyJZ,WooD,YehRW,TurnerMB.Executivesummary:heartdiseaseandstrokestatistics-2015update:areportfromtheAmericanHeartAssociation.AmericanHeartAssociationStatisticsCommitteeandStrokeStatisticsSubcommittee.Circulation.2015Jan27;131(4):434-41.doi:10.1161/CIR.0000000000000157.

249. GaoF,EarnestA,MatcharDB,CampbellMJ,MachinD.Samplesizecalculationsforthedesignofclusterrandomizedtrials:Asummaryofmethodology.ContemporaryClinicalTrials.2015Mar9;42:41-50.doi:10.1016/j.cct.2015.02.011.

250. MatcharDB,NguyenHV,TianY.Bundledpaymentandcareofacutestroke:Whatdoesittaketomakeitwork?Stroke.2015Apr9.pii:STROKEAHA.115.009089.

251. AnsahJP,MalhotraR,LewN,ChiuCT,ChanA,BayerS,MatcharDB.Projectionofyoung-oldandold-oldwithfunctionaldisability:Doesaccountingforthechangingeducationalcompositionoftheelderlypopulationmakeadifference?PLoS One. 2015 May 14;10(5):e0126471. doi: 10.1371/journal.pone.0126471. eCollection 2015.

252. ZeitlerEP,PokorneySD,ZhouK,LewisRK,GreenfieldRA,DaubertJP,MatcharDB,PicciniJP.Cable

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externalizationandelectricalfailureoftheRiatafamilyofimplantablecardioverter-defibrillatorleads:Asystematicreviewandmeta-analysis.HeartRhythm.2015Jun;12(6):1233-40.doi:10.1016/j.hrthm.2015.03.005.

253. LiuC,EomK,MatcharDB,ChongWF,ChanAW.Community-basedlong-termcareservices:Ifwebuildit,willtheycome?JournalofAgingandHealth.2015Jun30.pii:0898264315590229.

254. NgeowJ,LiuC,ZhouK,FrickKD,MatcharDB,EngC.DetectinggermlinePTENmutationsamongat-riskcancerpatients:Anage-andgender-specificcosteffectivenessanalysis.JournalofClinicalOncology.2015 Jul 13. pii: JCO.2014.60.3456.

255. Matchar DB,BilgerM,DoYK,andEomK.Internationalcomparisonofpoststrokeresourceuse:AlongitudinalanalysisinEurope.JournalofStrokeandCerebrovascularDiseases.2015Aug12.pii:S1052-3057(15)00345-6.doi:10.1016/j.jstrokecerebroThevasdis.2015.06.020.

256. CheiCL,RamanP,ChingCK,YinZX,ShiXM,ZengY,MatcharDB.PrevalenceandriskfactorsofatrialfibrillationinChineseelderly:ResultsfromtheChineseLongitudinalHealthyLongevitySurvey.ChineseMedicalJournal(England).201520thSep;128(18):2426-2432.doi:10.4103/0366-6999.164918.

257. FrancisK,YuC,AlvrtsyanH,SanderS,GhoshS,RaoY,SanchezH,MatcharD.Healthcareutilizationandcostsassociatedwithdabigatrancomparedtowarfarintreatmentinnewlydiagnosedpatientswithnon-valvularatrialfibrillation.Current Medical Research and Opinion. 2015 Dec;31(12):2189-95. doi: 10.1185/03007995.2015.1092124. Epub 2015 Sep 24.

258. MalhotraR,CheiCL,MenonE,ChowWL,QuahS,ChanA,MatcharDB.Short-termtrajectoriesofdepressivesymptomsinstrokesurvivorsandtheirfamilycaregivers.JournalofStrokeandCerebrovascularDiseases.2015Oct14.Pii:S1052-3057(15)00498-X.doi:10.1016/j.jstrokecerebrovasdis.2015.09.012.

259. AnsahJP,DeKorneD,BayerS,PanC,JayabaskarT,MatcharDB,LewN,PhuaA,KohV,LamoureuxE,QuekD. FuturerequirementsforandsupplyofophthalmologistsforanagingpopulationinSingapore.Human Resources for Health. 2015 Nov 17;13(1):86. doi: 10.1186/s12960-015-0085-4.

260. RoseAJ,PhibbsCS,UyedaL,SuP,EdsonR,ShihMC,JacobsonA,MatcharDB.Doesdistancemodifytheeffectofself-testinginoralanticoagulation?TheAmericanJournalofManagedCare.2016Jan;22(1):65-71.

261. LvYB,YinZX,CheiCL,BrasherMS,ZhangJ,KrausVB,QianF,ShiXM,MatcharDB,ZengY.SerumcholesterollevelswithinthehighnormalrangeareassociatedwithbettercognitiveperformanceamongChineseelderly. TheJournalofNutrition,Health&Aging.March2016,Volume20,Issue3,pp280-287.doi:10.1007/s12603-016-0701-6.

262. AnsahJP,MatcharDB,MalhotraR,LoverSR,LiuC,DoY.Projectingtheeffectsoflong-termcarepolicyonthelabormarketparticipationofprimaryinformalfamilycaregiversofelderlywithdisability:insightsfromadynamicsimulationmodel.BMCGeriatrics.2016Mar23;16(1):69.Doi:10.1186/s12877-016-0243-0.

263. ChanA,MalhotraR,MatcharDB,MaS,SaitoY.Gender,educationalandethnicdifferencesinactivelifeexpectancyamongolderSingaporeans.Geriatrics&GerontologyInternational.2016;16(4):466-473

264. TianY,HassmillerLichK,OsgoodND,EomK,MatcharDB.Linkedsensitivityanalysis,calibration,anduncertaintyanalysisusingasystemdynamicsmodelforstrokecomparativeeffectivenessresearch.MedicalDecisionMaking.2016Apr18.pii:0272989X16643940.

265. MatcharDB,CheiCL,YinZX,KohV,ChakrabortyB,ShiXM,ZengY.VitaminDlevelsandtheriskofcognitivedeclineinChineseelderly:theChineseLongitudinalHealthyLongevitySurvey.TheJournalsofGerontologySeriesA:BiomedicalSciencesandMedSciences.2016Jul12.pii:glw128.

266. BeeYM,Batcagan-AbuegAPM,CheiCL,DoYK,HaalandB,GohSY,LeePC,ChiamPS,HoTL,MatcharDB.Asmartphoneapplicationtodeliveratreat-to-targetinsulintitrationalgorithmininsulin-naïvepatientswithtype2diabetes:apilotrandomizedcontrolledtrial.DiabetesCare.DiabetesCare.2016Aug9.pii:dc160419.

267. WongN,ChuaSJ,GaoF,SimST,MatcharDB,WongSL,YeoKK,TanWC,ChinCT.Theeffectofanurse-ledtelephone-basedcarecoordinationprogramonthefollow-upandcontrolofcardiovascularriskfactorsinpatientswithcoronaryarterydisease.InternationalJournalQualityinHealthCare.2016Sep12.doi:10.1093/intqhc/mzw103

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268. PhibbsCS,LoveSR,JacobsonAK,EdsonR,SuP,UyedaL,MatcharDB.At-homeversusin-clinicINRmonitoring:Acost-utilityanalysisfromthehomeINRstudy(THINRS).JournalofGeneralInternalMedicine.2016Sep;31(9):1061-7.doi:10.1007/s11606-016-3700-8.

269. SchoenenbergerLK,BayerS,AnsahJP,MatcharDB,MohanavalliRL,LamSS,OngME.EmergencydepartmentcrowdinginSingapore:Insightsfromasystemsthinkingapproach.SAGEOpenMedicine.2016Oct4;4:2050312116671953.

270. TanG,ZhouK,TanCH,MatcharDB,FaridM,QuekR,NgeowJ.Cost-effectivenessofUniversalHepatitisBVirus(HBV)screeninginpatientsbeginningchemotherapyforsarcomaandGastrointestinalStromalTumors(GIST).JournalofGlobalOncology.Dec2015.(accepted)

271. MatcharDB,DuncanPW,LienC,OngMEH,LeeM,FeiG,SimR,andEomK.Arandomizedcontrolledtrialofscreening,riskmodificationandphysicaltherapytopreventfallsamongtheelderlyrecentlydischargedfromtheemergencydepartmenttothecommunity:ThestepstoavoidFallsintheElderly(SAFE)Study.ArchivesofPhysicalMedicineandRehabilitation.(UnderReview)

272. MatcharDB,ZhouK,WongCH,VidyarthiA.WheretoGoIfNottheHospital?ReviewingGeriatricBedUtilizationinanAcuteHospitalinSingapore.Geriatrics&GerontologyInternational.Sep2016.(Inpress)

Letters:

1. MatcharDB,PaukerSG.Endarterectomyincarotid-arterydisease-reply.JAMA-JournaloftheAmerican

MedicalAssociation.258(24):3514-3514.1987.2. FeussnerJR,MatcharDB.Carotidendarterectomy-reply.AnnalsofInternalMedicine.111(6):540-541.

1989.3. FeussnerJR,MatcharDB.Carotidendarterectomy-response.AnnalsofInternalMedicine.111(5):443-

444.1989.4. SimelDL,PiscitelliJ,MatcharDB.Intravenouspyelographybeforehysterectomy.AnnalsofInternal

Medicine.3:541.1989.5. MurphyDJ,MatcharDB.TheutilityofCPRinelderlypersons-reply.JAMA-JournaloftheAmerican

MedicalAssociation.265(7):866-866.1991.6. SimelDL,MatcharDB,FeussnerJR.Chance-correctedsensitivityandspecificityfor3-zonediagnostic-tests

-response.JournalofClinicalEpidemiology.45(9):1038-1039.1992.7. SchapiraMM,MatcharDB,YoungMJ.Whenandwhomtoscreen-reply.AnnalsofInternalMedicine.

119(11):1152-1152.1993.8. GoldsteinLB,McCroryDC,LandsmanPB,SamsaGP,AncukiewiczM,OddoneEZ,MatcharDB.

Preoperativerisk-factorsforcarotidendarterectomy-reply.Stroke.25(10):2097-2097.1994.9. MatcharDB,McCroryDC,BarnettHJ,FeussnerJR.Medical-treatmentforstrokeprevention(vol121,pg

41,1994).AnnalsofInternalMedicine.121(6):470-470.1994.10. MatcharDB,McCroryD,PritchettELC.Managementofchronicasymptomaticatrialfibrillation.Annalsof

InternalMedicine.6:466-467.1994.11. MatcharDB,McCroryDC,BarnettHJ,FeussnerJR.Medical-treatmentofstrokeprevention(vol121,pg

41,1994).AnnalsofInternalMedicine.122(11):885-885.1995.12. MatcharDB.Strokepreventionguidelines-reply.AnnalsofInternalMedicine.122(3):235-236.1995.13. OddoneE,BlakeleyD,MatcharDB.Noninvasivecarotid-arterytesting-reply.AnnalsofInternalMedicine.

123(8):634-634.1995.14. TsevatJ,MatcharDB,WuAW.Healthvaluesoftheseriouslyill-response.AnnalsofInternalMedicine.

124(2):279-279.1996.15. MatcharDB,SamsaG,CohenS.Shouldwejustlettheanticoagulationservicedoit?Reply.Journalof

GeneralInternalMedicine.12(4):259-259.1997.16. BeneschC,WilderAL,WitterDM,DuncanPW,SamsaGP,MatcharDB.Inaccuracyoftheicd-9-cmin

identifyingthediagnosisofischemiccerebrovasculardisease-reply.Neurology.51(3):922-922,1998.

19

17. BillerJ,CastaldoJE,WhittemoreAD,HarbaughRE,DempseyRJ,CaplanLR,KresowikTF,MatcharDB,TooleJF,EastonJD,AdamsHP,BrassLM,HobsonRW,BrottTG,SternauL.Concernsregardingcarotidendarterectomyguidelines-response.Stroke.29(7):1475-1476,1998.

18. OddoneEZ,HornerR,MatcharDB.Racialinequityofaccesstocarotidimaging-response.Stroke.30(11):2491-2491,1999.

Booksorchaptersinbooks:

1. MatcharDB.Decisionanalysis.In:CohenHJ,ed.IntroductiontoMethodologiesforClinicalResearchinGeriatrics(SummerResearchWorkshop,July30-August5,1989).NewYork,NY:AmericanGeriatricsSociety.1990.

2. MatcharDB,GoldsteinLB,McCroryDC,OddoneEZ,JansenDA,HilbourneLH,ParkRE.CarotidEndarterectomy:Aliteraturereviewandratingsofappropriatenessandnecessity.RAND,JRA-05.1992.

3. MatcharDB.Applicationofdecisionanalysistoguidelinedevelopment.In:McCormickKA,MooreSR,SiegelRA,eds.ClinicalPracticeGuidelineDevelopment:MethodologyPerspectives.Rockville,MD:AgencyforHealthCarePolicyResearch.35-40.AHCPRPub.No.95-0009.1994.

4. ParmigianiG,AncukiewiczM,MatcharDB.Decisionmodelsinclinicalrecommendationsdevelopment:theStrokePreventionPolicyModel.In:BerryDA,StanglDK,eds.BayesianBiostatistics.NewYork,NY:MarcelDekker.207-233.1996.

5. MatcharDB,PaukJS,LipscombJ.Ahealthpolicyperspectiveoncarotidendarterectomy:cost,effectiveness,andcost-effectiveness.In:MooreWS,ed.SurgeryforCerebrovascularDisease.NewYork,NY:ChurchillLivingstone.680-689.1987.

6. MatcharDB,AbrahamseP,LipscombJ,SamsaG.Policyperspectiveonacutestroketreatment.In:ShoaibA,GoldsteinLB,eds.ManagementofAcuteStroke(NeurologicalDiseaseandTherapy).NewYork,NY:MarcelDekker.1-14.1999.

7. MatcharDB.Linkinghealthpolicymodelingwithhealthpolicyformationandimplementation.In:ChapmanGB,SonnenbergFA,eds.DecisionMakinginHealthCare:Theory,Psychology,andApplications.Cambridge,UK:CambridgeUniversityPress.145-157.2000

8. MatcharDB,SamsaGP.Frequencyoftestingandtherapeuticeffectiveness.In:AnsellJE,OertelLB,WittkowskyAK,eds.ManagingOralAnticoagulationTherapy:ClinicalandOperationalGuidelines.Gaithersburg,MD:AspenPublishers.1-5.2002

9. MatcharDB.ImprovingAdherencewithClinicalGuidelines.In:BosworthHB.,OddoneEZ.,WeinbergerM,eds.Patienttreatmentadherence:Concepts,interventions,andmeasurement.Mahwah,NJ:LawrenceErlbaumAssociates.2006.

10. MatcharDB,OrlandoLA.Therelationshipbetweentestandoutcome.In:PriceCP,ChristensonRH,eds.Evidence-basedLaboratoryMedicine.Washington,DC:AACCPress.53-66.2007

11. CommitteeonTreatmentofPosttraumaticStressDisorder.InstituteofMedicine(IOM).TreatmentofPosttraumaticStressDisorder:Anassessmentoftheevidence.TheNationalAcademiesPress.2007.

12. IrisGrossman,MugdhaThakur,andMatcharDB.Chapter32:In:CaseStudies:Assessingtheuseofgeneticinformationinpracticeforspecificdiseases.CytochromeP450testinginthetreatmentofdepression.Oxford,UK:OxfordUniversityPress:HumanGenomeEpidemiology.2007.

13. MatcharDB.Registriesforevaluatingpatientoutcomes:Auser’sguidesecondedition.Chapter1:PatientRegistries.Rockville,MD:AgencyforHealthcareResearchandQuality.9-19.2010.

14. SmetanaGW,UmscheidCA,ChangS,MatcharDB.Editorial:MethodsGuideforAuthorsofSystematicReviewsofMedicalTests:ACollaborationbetweentheAgencyforHealthcareResearchandQuality(AHRQ)andtheJournalofGeneralInternalMedicine.AgencyforHealthcareResearchandQuality(US);2012.

15. MatcharDB.IntroductiontotheMethodsGuideforMedicalTestReviews.In:ChangSM,MatcharDB,SmetanaGW,UmscheidCA,editors.MethodsGuideforMedicalTestReviews[Internet].Rockville(MD):AgencyforHealthcareResearchandQuality(US);2012.Chapter1.

16. SantaguidaPL,RileyCM,MatcharDB.AssessingRiskofBiasasaDomainofQualityinMedicalTestStudies.AgencyforHealthcareResearchandQuality(US);2012.Chapter5.

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17. HartmannKE,MatcharDB,ChangSM.AssessingApplicabilityofMedicalTestStudiesinSystematicReviews.AgencyforHealthcareResearchandQuality(US);2012.Chapter6.

18. SinghS,ChangSM,MatcharDB,BassEB.GradingaBodyofEvidenceonDiagnosticTests.In:ChangSM,MatcharDB,SmetanaGW,UmscheidCA,editors.MethodsGuideforMedicalTestReviews[Internet].Rockville(MD):AgencyforHealthcareResearchandQuality(US);2012.Chapter7.

19. JonasDE,WiltTJ,TaylorBC,WilkinsTM,MatcharDB.ChallengesinandPrinciplesforConductingSystematicReviewsofGeneticTestsUsedasPredictiveIndicators.AgencyforHealthcareResearchandQuality(US);2012.Chapter11.

SocietyMemberships:1984 AmericanCollegeofPhysicians

Fellow(1990)Advisor,HealthandPublicPolicy(1986)

1984 SocietyforGeneralInternalMedicineNominatingCommittee(1989)President,SouthernSection(1988)Chairman,AbstractReviewCommittee(1991)

1984 SydenhamSociety

1987-1990 AmericanFederationforClinicalResearch

1985 SocietyofMedicalDecisionMakingEditorialBoard(1990)Chairman,1993AnnualMeetingBoardofTrustees(1994)VicePresident(1996)

1995 AmericanAcademyofNeurology,HeadacheandFacialPain

1997 AmericanHeartAssociationStrokeCouncilFellow

1999 InternationalSocietyforPharmacoeconomicsandOutcomesResearch

2003 AmericanHeadacheSociety

2010–20112010–2017

GerontologicalSocietyofAmericaAcademyHealth

National/InternationalCommittees:1986 HospitalBasedHomeCareAdvisoryCommittee

1989 AcademicMedicalCentersConsortium,CommitteeofHealthServicesResearchLiaison(AMCC-CHSRL)

21

1990 TaskForce,CenterforYouth

1991 JournalofHealthPublicPolicyandLawManagementCommittee

1992 NorthCarolinaCervicalCancerTaskForce

1994 BreastCancerAmongWomenVeterans:Pilot/FeasibilityStudy(VAHSRSDR#92-006)AdvisoryCommittee

1996 NorthCarolinaStrokePreventionCommittee

1996 ValueMeasurementSystemsOversightCommittee

1996 Chair,NationalCancerInstituteofCanadaStudySection

1998 RepresentativetoG7HealthcareProject,EvidenceandEffectiveness

1998 ACPRepresentative,HeadacheGuidelineConsortium

1998 VAStrokeQualityEnhancementResearchInitiative(QUERI)OperationsCommittee

1999 NationalInstituteforNeurologicalDisordersandStrokeProgressReviewGroup(2001)Advisor(2003)

2000-2003 ImprovingChronicIllnessCare,RobertWoodJohnsonFoundationNationalAdvisoryCommittee

2002 AdvisoryBoard,VARehabilitationOutcomesResearchCenter

2002 AdvisoryBoard,AmericanHeadacheSociety

2003 AdvisoryPanel,Disease-SpecificCareStrokePerformanceMeasure,JointCommissiononAccreditationofHealthcareOrganization

2004 NationalIntegratedStrokeTreatmentEducationProgramSteeringCommittee

2005-2006 InstituteofMedicine(IOM)CommitteeontheGulfWarandHealth:LiteratureReview

2005 AdvisoryBoard,NationalHealthCareSurveyForumattheNationalCenterforHealthStatistics

2005

Chair,NeurovascularCoalitionCarotidStentTaskForce

2006-2009

CoordinatingPanelRepresentative,NationalKidneyDiseaseEducationProgram(NKDEP)

2006-2007 InstituteofMedicine(IOM),CommitteeonTreatmentofPosttraumaticStressDisorder,BoardonPopulationHealthandPublicHealthPractice

2005-2007 WHOCommitteeOnBloodPressureMeasurementInLowResourceSettings

2008 CDCK01AwardProgram

22

2008 Chairman,ExecutiveCommittee,StrokeQualityEnhancementResearchInitiative,DepartmentofVeteransAffairs

2008 SearchCommittee,DukeGlobalHealthInstitute

2008(Singapore)-

SingHealthHRPlatformsWorkgroup(forClinicalResearchManpower)

Chairman,SingHealthReviewCommitteeforHealthServicesResearchFund

CommitteeforMOHontheElectronicHealthRecord

PlanningCommitteefortheHealthTechnologyAssessmentInternationalMeetingforSingapore2009

Duke-NUSCentreofQuantitativeBiology&Medicine(CQBM)Committee

2009(Singapore)-

Chairman,SingHealthDuke-NUSScientificCongress2010

Adviser,NationalTraumaRegistry(NTR)AdvisoryCommittee(NTRAC)

Member,NationalMedicalResearchCouncil(NMRC)LocalReviewPanel

Chairman,SingHealthGrantReviewCommittee(HealthServicesResearch)

ConsultantandScientificAdviser,SingaporeClinicalResearchInstitute

2010(Singapore)-

Member,InternationalAdvisoryCommittee(MOHHealthServicesResearchCompetitiveResearchGrant.

2011-2014(HongKong)

ExternalExaminer,Dissertation(MastersofPublicHealth),TheUniversityofHongKongChiefExaminer,MastersofPublicHealthVivaExamination,TheUniversityofHongKong

2011(Singapore)-

Member,Duke-NUSEmergingInfectiousDiseasesProgramSearchCommitteeMember,SpecialistsAccreditationBoard(SAB)ResearchCommitteeChairperson,ResearchSub-GroupfortheNationalStrategyforPalliativeCareProjectMember,WorkgroupfortheNationalStrategyforPalliativeCareProjectMember,LienCentreforPalliativeCareScientificAdvisoryBoardMember,ProjectSCOPEConsultativeCommittee(PSCC)oftheSelf-CareonHealthofOlderPeopleinSingapore(ProjectScope).MemberoftheScientificCommittee,SecondGlobalSymposiumonHSR

2012-2013 Member,NationalMedicalResearchCouncil(NMRC)LocalReviewPanelfortheCS-IRGAdvisoryBoardMember,ActiveGlobalHealthSciencesEducationGroup

2013-2014 Member,AcademicMedicineResearchInstitute(AMRI)AdvisoryCommittee

23

2013-20152013

Member,SpecialistsAccreditationBoard(SAB)ResearchCommitteeNIHProgramAdvisoryCommittee,FloridaPuertoRicoCollaborationtoReduceStrokeDisparities

2015-2017 Member,SpecialistsAccreditationBoard(SAB)ResearchCommittee2015 ScientificAdvisor,ResearchDataAnonymizationGovernance(RDAG)Workgroup2015 Member,NationalHealthServicesResearchStrategyWorkgroup2015–2018 Member,StrategicThrust#1“DevelopResearchFocusAreasIntoWorldLeadingPrograms”Working Committee2016–2019 Member,ExternalAdvisoryBoard(EAB)forIMSInstituteforHealthcareInformatics2016–2018 Member,NationalCouncilofSocialServiceAdvocacyandResearchPanelEditorialBoardsandConsultancies:1989 AmericanCancerSocietyWorkshoponClinicalTrial

1990 CombinedMedicalSpecialtiesSocieties

1991 Consultant,AsymptomaticCarotidAtherosclerosisStudy(ACAS)

1991 Consultant,PfizerPharmaceuticals

1991 Contractor,ElectiveSurgeryAlgorithmProject(ESAP),ConsultanttoHCFA

1993 Consultant,ThomasJeffersonHealthPolicyInstitute

1993 CentersforDiseaseControlandPrevention(CDC)

1994 Consultant,JanssenResearchFoundation

1995 CardiovascularMedicalAdvisoryBoard,MedcoContainmentServices

1995 Consultant,DuPontPharmaceutical

1995 Consultant,Wyeth-AyerstResearch

1996-1998

SeniorEditor(1997),EditorialBoard,SynapsePublishing

2013Member,BoardofTrusteeforSMDM2014-2016 Member,NationalMedicalResearchCouncil(NMRC)LocalReviewPanelfortheCS-IRG2014-2017 VisitingScientist,NationalHeartResearchInstituteofSingaporeundertheNationalHeartCentre ofSingaporePteLtd20

24

1997 Consultant,Johnson&Johnson

1999-2008 Principal,RequisiteConsultingGroup,Inc

2000 EditorialBoard,AmericanJournalofMedicine

2001 SectionEditor,Stroke,HealthPolicy/OutcomesResearch,

2001 EditorialBoard,HealthServicesandOutcomesResearchMethodology

2001-2005 EditorialBoard,ClinicalEvidence,BritishMedicalJournal

2003-2004 MIPlusExpertPanel,CenterforOutcomesandEffectivenessResearchandEducation,UniversityofAlabamaatBirmingham

2004 Consultant,Rocheforeducationalprogramsrelatedtooptimizinganticoagulationmanagement

2008 Consultant,BoehringerIngelheim,AtrialFibrillationRegistryStudy

2008 Editor,DiagnosticTestGuidancefortheAgencyforHealthCarePolicyandResearch

2011 AssociateEditor,InternationalJournalofSystemDynamicsApplications(IJSDA)

2011 SeniorAssociateEditor,HealthServicesResearchJournal

Reviewer(JournalorOrganization):1987 AnnalsofInternalMedicine

1987 JournaloftheAmericanMedicalAssociation

1988 JournalofGeneralInternalMedicine

1989 JournalofGerontology:MedicalSciences

1989 MayoClinicProceedings

1989 AmericanJournalofMedicine

1989 JournalofClinicalEpidemiology

1990 AmericanCollegeofGastroenterology

1991 HealthServicesResearch

1991 CambridgeUniversityPress,

Adhocreviewer(1997,1998)

1992 AnnalsofNeurology

1992 JournalofNeurologicalSciences

25

1993-1997 DepartmentofHealthandHumanServices,AgencyforHealthCarePolicyandResearch,HealthCareTechnologyStudySection

1996 JournalofInvestigativeDermatology

1999 NationalInstituteforNeurologicalDisordersandStrokeStudySection

2001 Stroke

2001-2004 AgencyforHealthcareResearchandQuality,HealthResearchDissemination&ImplementationStudySection

2004 CentersforDiseaseControlandPreventionK01TrainingGrantProgram

2004 NationalInstitutesofHealth,RoadmapRFAreview:"DynamicAssessmentofPatient-ReportedChronicDiseaseOutcomes

2009 German-IsraeliFoundationforScientificResearchandDevelopmentGeneticandepigeneticdeterminantsofCYP2C9Grant

2010

TheNewEnglandJournalofMedicine

2011201420152015

AnnalsAcademyofMedicineSingaporeAgencyforHealthcareResearchandQualityTheAmericanHeartJournalAgencyHealthcareResearchandQuality

Professionalawardsandspecialrecognitions:1980 CumLaudeUniversityofMarylandSchoolofMedicine

1980 AlphaOmegaAlphaHonorMedicalSociety

1984 AWMellonFellowshipinMedicalDecisionSciences

1994 Who'sWhointheSouthandSouthwest

1995 Who'sWhoinAmerica

1995 Who’sWhoinAmericanEducation

26

2003 Who'sWhoinMedicineandHealthcare

2003 Who'sWhoinScienceandEngineering

2005

Who'sWhointheWorld

Teachingresponsibilities:

1984-1992 CriticalAppraisaloftheLiterature-Offeredtoseniormedicalresidents

1985-1986 EpidemiologyforClinicians-Offeredtoclinicalresearchfellowsandclinicalfaculty

1986-1987 ClinicalDecisionAnalysis-Offeredtoclinicalresearchfellowsandclinicalfaculty

1988-1997 ClinicalDecisionAnalysisBMI217-MastersofBiometryProgram

2002-2008 HealthEconomicsinClinicalResearch(CRTP244)-MastersofHealthScience(ClinicalResearch)

2002-2004 MedicalPracticeandHealthSystems-Offeredtomedicalstudents(teaches6classesperyear)

2010 IntegrativeBiologyandMedicineGraduateProgram

2010 IntroductiontoHealthServicesResearch(CO5214)–MastersofClinicalInvestigation(MCI)Program

HouseStaffTeachingandWardAttending:1985-1993 CriticalAppraisalJournalClub-onesessionperweek

1985-1991 ProblemsinAmbulatoryCareMedicine-onesessionperweek

1985-2008 WardAttending,GeneralInternalMedicine-onemonthperyear

Areasofresearchinterests:Generaltheme:

Formationandimplementationofclinicalhealthpolicy

Clinicalresearch:

Evaluationandtreatmentofpatientswithcerebrovasculardiseaseandsimilarlycommonmedicaldisorders

Methodology: Cohortanalyticstudies,technologyassessment,clinicaldecisionanalysis,cost-effectivenessanalysis,classificationtechniques,Bayesiananalysis,randomizedtrialsforevaluationofclinicalimprovementstrategies

ClinicalPractice:

1985-2008 GeneralInternalMedicine:10%,1half-daysessionperweek

27

DukeUniversityMedicalCenterActivities:1986 DivisionofGeneralInternalMedicineSearchCommittee,Chief

1990 DukeUniversityPress

1990 CouncilonAgingandHumanDevelopment

1991-2000 InstitutionalReviewBoard,DukeUniversity

1992 JournalofHealthPolitics,PolicyandLaw,[JHPPL]ManagementBoard

1992 DepartmentofCommunityandFamilyMedicineSearchCommittee

1992 MHCRCforDepressioninLateLifeAdvisoryCommittee

1993 GovernmentResourcesCommittee

1994 InternalAdvisoryBoard,ExploratoryCenterforResearchonHealthPromotioninOlderMinorities

1998 Dean'sClinicalResearchCommittee

1995 AcademicComputingAdvisoryCommittee

1996 DiseaseManagementCommittee

2003 Alzheimer'sDiseaseResearchCenter

2003 MentoredClinicalResearchScholarsProgram

2004-2008 StudyDirector,ThirdYearDualDegreeProgram

2007 PromotionsandTenureCommittee

DurhamVeteransAffairsActivities:1987 VAQualityAssuranceCommittee

1988 VAMedicalRecordsCommittee

1996 PharmacyandTherapeuticsCommittee,VAMC,Durham

28

ResearchGrants:04/16–04/19($456,500)Co-PrincipalInvestigator06/15–06/19($10,500)Co-PrincipalInvestigator01/15–01/18(S$296,000)PrincipalInvestigator04/15–03/17($50,000)Mentor02/14–07/17($366,387)PrincipalInvestigator01/12–08/13($109,650)Co-Investigator

DesignandAnalysisToolsforData-drivenMobileHealthInterventionsSingaporeInfragenicularAngioplastywithPaclitaxel-elutingballoonforCriticalLimbIschaemia(SINGA-PACLI)TrialTheSingaporeInfra-genicularangioplastywithpaclitaxel-elutingballoonforcriticallimbischaemia(SINGA-PACLI)TrialaimstoinvestigatewhetherDEBPTAresultsinbetterpatencyratesthanCBPTAinbelow-the-kneearteriallesions.ThehypothesisofthisstudyisthatDEBPTAresultsinimprovedpatencyratescomparedtoCBPTAforthetreatmentofinfrageniculararteriallesionsinpatientswithCLI.Ifso,DEBPTAisexpectedtoimprovelimbsalvagerates,preventcomplicationsassociatedwithlowerlimbamputations,andhelpimprovequalityoflife.Furthermore,DEBPTAcouldpotentiallybemorecost-effectivethanCBPTAandinformdecision-makerstoallocateresourcesforthisprocedure.ARandomizedControlledTrialtoImprovetheUptakeofandAdherencetoOutpatientRehabilitationServiceamongStrokePatientsArandomizedcontrolledtrialtotest3interventionstrategiesaimedatimprovingtheuptakeofandadherencetooutpatientrehabilitationservice.DiscreteEventSimulationofaPrimaryAngleClosureGlaucomaModelinSingaporeHealthandEconomicEvaluationoftheAging-In-PlacePrograminapublichospitalinSingaporeTheAginginPlace(AIP)programisaninterventionprogramforNorthSingaporebasedontheconceptof“integratedcare”.AIPembedsanetworkofcommunitynurseswhoseektoimprovehealthoftheindividualswhoarefrequentusersofhospitalcare.ThisproposedstudycomprisingofbothqualitativeandquantitativeanalysisisproposedtoevaluatetheeffectivenessofAIPprogramonresource-intensivepatients’healthcareutilizations,costs,andoutcomes.Developingsimulation-basedparametrisationmethodsformodelsofsexuallytransmittedinfection:makingpolicyrecommendationsevidence-basedOneofthemaingoalsofNIHAistocontributetopolicyformulationgenerallyintheareaofhealthandinpublichealthinparticular.STIsareamajorpublichealthconcerninSingaporeand,especially,inneighbouringcountriessuchasThailand,andatthemomentSingaporedoesnothavethecapacitytodeployproperlyconstructedmodelsofSTIstoaddressimportantpolicyquestionssuchashoweffectivewouldapartnernotificationprogrammebeinreducingchlamydia,orhowmuchwouldtheburdenofGonorrheabeimpactedbyimplementingroutinescreeningofparticularriskgroups.ForsuchmodelstoberepresentativeoftheactualsituationinSingaporeoranothercountryintheregion,itisimperativethattheybegroundedinrigorousstatisticalmethodstoderivegenuineestimatesoftheirparameters,butatthemoment,themajorityofsuchmodelsareparametrisedinaveryadhocfashion,creatingsubstantialdoubtaboutthepolicyimplicationsderivedfromthem.

29

04/12–12/15($236,800)PrincipalInvestigator

Feasibility of using a smart phone application for self-titration of insulin on glycemic control inpatientswithtype2diabetesIn this feasibilitystudy,wehypothesizeusingasmartphoneapplication for insulinself-titration iseffectiveinimprovingglycemiccontrolinT2DMpatientscomparedwithusualcare.Thisstudywillprovideacriticalevidencebasetothefeasibilityofthisinnovativeinterventioninahospital-basedclinic and therefore establish sound preliminary data for seeking a large-scale grant testing itsapplicabilityinmoregeneralsettings,includingpolyclinics.

12/11–08/15(S$980,300)Co-Investigator08/11–07/14($97,983)Co-Investigator

ARandomizedTrialofEconomicIncentivestoPromoteWalkingAmongFullTimeEmployeesThisstudywillassessthereach(i.e.,uptake),effectiveness,andcost-effectivenessofascalableincentive-drivenemployerbasedwalkingprogrambothwithandwithoutincentives,throughastatedpreferenceconjointsurveyandafour-arm(control,basicwalkingprogram,basicprogramwithcashincentives,basicprogramwithincentivesdedicatedtocharity)randomizedcontrolledtrial(RCT)wherethekeyoutcomevariableisdefinedasbouts(inminutes)ofmoderatetovigorousphysicalactivity(“MVPAbouts”).Thestudyaimsto:(1)Assessthereachandsustainabilityofemployer-basedwalkingprograms,bothwithandwithouteconomicincentives;(2)Quantifytheeffectivenessofa6-monthevidence-basedwalkingprogrambothwithandwithoutincentives;and(3)Determinethecosttoemployersofimplementingeachprogramandtheincrementalcost-effectivenessoftheincentiveprogramscomparedtothebasicprogramwithoutincentives.SingaporeProgramforAllInclusiveCarefortheElderly(SingaPACE)ImpactEvaluation:EvidencefromaRandomizedControlledTrialImpactevaluationoftheeffectivenessofSingaPACE.AppliedtoAICbecauseofitsinterestinresearchmethodologytoassesslongtermcareoptionsinSingapore.

08/11–10/14($502,004)Co-Investigator

SelfCareforOlderPersonsinSingapore:AninterventionStudy(SCOPEakaSCOPA)Interventionprogramtobuildthecapacityofolderpeopleforself-care.

09/11–05/15($872,218)PrincipalInvestigator

Multifactorial,evidence-basedprogramofscreening,riskmodificationandphysicaltherapytopreventfallsamongvulnerableelderlyrecentlydischargedfromhospitaltocommunityTodevelopanddemonstrateeffectivenessofamultifactorial,communitybased,fallspreventionprogramofscreening,riskmodificationandphysicaltherapythattargetselderlySingaporeansathighriskoffalls.

09/10–08/13($465,500)Investigator

Optimizinglocalmanagementofglobalpandemics–amodelingapproachThis study has three main components: 1) statistical analysis of outbreak and epidemic data, 2)modelingepidemicspreadandeffectivenessofdifferentinterventions,and3)economicandpolicyanalysisoncost-benefitandoptimalmixofstrategies

02/11-02/13($394,620)Co-Investigator

CardiacArrestandResuscitationEpidemiologyinSingapore:ComparisonofOutcomeswithImplementationofSystemsStatusPlan(CAREIV)Thisisanobservationalprospectivestudylookingatresponsetimesandsurvivaloutcomesforemergencymedicalservices(EMS)beforeandafterimplementationofaSystemsStatusPlan(SSP).

04/11-04/13($182,700)Co-Investigator

IntegratedHospitalSimulationModel(MinistryofHealth)Theaimoftheresearchistodevelopabetterunderstandingandalsoquantificationofthevariousinteractions.Itcanthenserveasa“test”environmentforexploringnewwaysoforganisinghealthservices,ortofacilitateplanningofnewhospitals.

30

02/11-02/13(S$173,000)Co-Investigator

Thehealth,socialandfinancialeffectsofcare-givingamongprimaryandsecondarydomesticcaregiversofelderlystrokepatientsinthefirstpoststrokeyear:aprospectivestudyTheprimaryaimofthestudyistoprospectivelyassessthehealth,socialandfinancialeffectsofcareonacohortofstrokepatient-caregiverdyadsfromstrokeonsettooneyearpoststroke.

07/10–06/12($98,620)PrincipalInvestigator

Astudyoftheimpactofcaringforstrokesurvivorsonfamilystructureandthementalhealthofcaregivers(MinistryofCommunityDevelopment,YouthandSports)Interventionprogrammestominimizecaregivingburdenandallowstrokesurvivorstoremainlongerinthecommunity.

08/28/09–08/27/15($5,242,102)PrincipalInvestigator

Establishingapracticalandtheoreticalfoundationforcomprehensiveandintegratedcommunity,policyandacademiceffortstoimprovedementiacareinSingapore(NationalMedicalResearchCouncilandAgencyforScience,TechnologyandResearch)ToestablishalaboratoryinSingaporeforhealthsystemsmodelingwhichprovidesabasisforsystematicscenarioplanningtoofferinnovativeapproachtothechallengesofrapidgrowthofSingapore'sagedpopulationandconcomitantriseindementiaprevalence.

11/10/08-11/09/11($737,873)Co-Investigator

HealthTechnologyAssessmentCapacityBuildinginIndia(TemasekFoundation)ToenhancethemanagementofhealthcareandhospitalservicesinNorthIndiathroughbuildingcapabilityofhealthcareandhospitaladministrators,managersandcliniciansinrational,evidence-baseddecision-makinginhealthcarepolicyandpractice.Thiswillbeachievedthroughcreationofmodelsbothinthegovernmentandprivatesector.

10/01/07-09/30/12($1,500,000)NetworkDirector

Evidence-basedPracticeCentersIII(AgencyforHealthCarePolicyandResearch)Toconductcomparative-effectivenessreviews(CERonmedications,devices,andotherinterventions.(fundsawardedpertaskorder,effortisassignedatthattime)

10/01/07-02/28/10($224,023)Investigator

DEcIDEHealthOutcomesofCarotidArteryDisease(AgencyforHealthCarePolicyandResearch#290200500321-TO2-WA1-20EHC10)TheDukeDEcIDENetworkCenterproposestocollaboratewiththeCentersforMedicareandMedicaidServices(CMS)CoverageandAnalysisGrouptodevelopacomprehensiveapproachtoinformkeyclinicalandpolicyquestionsrelatedtoCAS(includingresearchneeds),thattakesmaximaladvantageofavailabledata,andlinkstotheexistingmechanismsfortechnicalassessmentavailabletoCMS.

09/30/07-07/31/12($499,447)PrincipalInvestigator

ExpandingQualityCareforGlaucomathroughaProvider-PatentPartnershipOurproposedstudyisacommunity-based,randomized,controlledtrialthatevaluatesthestabilityandeffectivenessofatechnology-based(tabletcomputer)interventionwithinthecontextofanovelpartnershipbetweenoptometristandpatientswithglaucomatoimprovetheprocessqualityofcareandultimatelyoutcomesofcare.

09/25/07-09/24/09($320,513)

CollaborativeResearchofClinicalEffectivenessandLongTermOutcomesofStentsinCoronaryInterventions(DEcIDENetwork)[AgencyforHealthCarePolicyandResearch#HHSA90200500321,TO#4]TwoDEcIDEcenterswillundertakeaseriesofvariedandinter-relatedresearchworkassignmentstounderstandthebenefitsandharmsofstentsincoronaryarterydisease.

31

09/01/07-08/31/12($58,000)Investigator

MethodsandDissemination(AgencyforHealthCarePolicyandResearch#290-2007-10066-IT.O.1)ThesupporttheproductionofqualityEvidenceReportsthatcanbeusedandunderstoodbyappropriatestakeholders,theEPCshallcommitadequatetimeandresourcestoadvancingthemethodologyofsystematicreview.TheEPCdirectorshallbeinvolvedinregularschedulecallswithAHRQtoidentify,discuss,andworktowardsdevelopingastandardapproachtokeymethodologicalissuesinsystematicreview.ThedegreeofinvolvementshallbedeterminedbyAHRQneeds,programpriorities,andEPCtechnicalresources.WhatapprovalfromAHRQ,theEPCshallalsosupportdisseminationofresearchfindingfromAHRQsupportedEOCreportthroughoralorwrittenpresentationtorelevantstakeholdersandthepublic.

03/19/08-09/30/09($390,528)PrincipalInvestigator

RenalPhysiciansAssociation–10-siteImplementationoftheAdvanceCKDGuidelineTosupporttheproductionofacomprehensiveevidencereport,clinicalpracticeguidelineandclinicalperformancemeasures,andtheAdvancedCKDPatentManagementToolkit.

09/30/05-09/30/09($974,026)($awardedperworkorder)

DEcIDEBroadBasedSupport(DEcIDENetwork)[AgencyforHealthCarePolicyandResearch#HHSA290200500321,TO#2]TodevelopnewscientificevidenceandmethodstoaddressknowledgegapsrelevanttoimprovingthehealthcaredeliveredthroughtheMedicare,Medicaid,andtheStateChildren’sHealthInsuranceprograms.

9/27/06-01/31/09($239,245)NetworkDirector

AProspectiveMulticenterTrialtoAssesstheEffectsofMedicationTherapyManagementonImprovingDrugSafetyandEffectivenessinMedicare(DEcIDENetwork)[AgencyforHealthCarePolicyandResearch#HHSA290200500321,TO#3]ToimprovemedicationsafetyinMedicarebeneficiaries.Focusonatleastthreeelements,(a)educationandcounselingpatientstoimproveunderstandingtheirmedications,(b)improvingadherencetomedications,(c)detectingadverseeventsandpatternsofprescriptionoveruseandunderuse.

12/01/07-11/30/08($160,000)Co-Investigator

FosteringImmediatePractice-AlteringClinicalTrials(KAIResearch,Inc.)Developamathematicalmodelthatcanprovideanestimateofthepotentialimpactofanygivenclinicaltrialinneurologyorneurosurgery.

02/01/06-06/30/06($105,000)PrincipleInvestigator

EvaluationofNon-invasiveTestsofCoronaryAnatomy(EPCII/CPTA)[AgencyforHealthCarePolicyandResearch-Contract#:290-02-0025,Sub#15-P3039939]

11/01/05-12/31/06($20,000)Investigator

GeneralRegistryFollow-up(EPCII/CPTA)[AgencyforHealthCarePolicyandResearch-Contract#:290-02-0025-P3039939]ToproduceareferenceforthedesignanduseofsuccessfulregistriesbothforregistriesthatmayberequiredbyCMSandregistriessetupforotherpurposesinboththepublicandprivatesectors.

11/01/05-10/16/06($110,000)PrincipleInvestigator

TestingforCytochromeP450PolymorphismsinAdultswithnon-PsychoticDepression(Evidence-basedPracticeCentersII)[AgencyforHealthCarePolicyandResearch#290-02-0025,TaskOrder#10]

32

10/1/05-9/30/07(upto$974,026)($awardedperTO)Director

Costreimbursementtaskordercontract-DEcIDENetwork(AgencyforHealthCarePolicyandResearch#HHSA290200500321)Provideavarietyofservicesandproductstosupportthedevelopmentofnewscientificknowledgethroughresearchontheoutcomesofthehealthcareitemsandservices.Developscientificevidenceandnewanalytictoolstoassisthealthcareproviders,patients,andpolicymakerswithmakinginformeddecisionsaboutthecomparativeeffectiveness,appropriateness,safety,andoutcomesofhealthcareitemsandservices,particularlyprescriptionandmedicationsandmedicaldevices.

09/30/05-06/30/06($162,000)Investigator

TreatmentofIn-stentRestenosis(DEcIDENetwork)[AgencyforHealthCarePolicyandResearch#HHSA290200500321,TO#1]Surveytheratesofrepeatrevascularizationinpatientswithbaremetalstentsanddrugelutingstentsoveramulti-yearfollowupperiod;surveytheutilizationoftreatmentusedforrepeatrevascularization,andoutcomesassociatedwiththesetreatments.

08/15/05-02/28/06($65,000)PrincipleInvestigator

EvaluationofQOLMeasuresinMacularDegeneration(EPCII/CPTA)[AgencyforHealthCarePolicyandResearch-Contract#:290-02-0025,Sub#13-P3039939]

08/01/05-07/31/07$698,052($awardedperworkorder)

ComparativeEffectivenessReviewsforMMASection1013(EPCII)[AgencyforHealthCarePolicyandResearch#290-02-0025]Toconductcomparative-effectivenessreviews(CER)onmedications,devices,andotherinterventions.

06/15/05-09/30/07($187,000)PrincipleInvestigator

ComparativeLong-termBenefitsandHarmsofACE-inhibitorsversusARBsforTreatingHypertension(Evidence-basedPracticeCentersII)[AgencyforHealthCarePolicyandResearch#290-02-0025,To#7/Work#1]

03/01/05-08/31/05($31,000)PrincipleInvestigator

EvaluationofPointofCareTestingofHgA1c(EPCII/CPTA)[AgencyforHealthCarePolicyandResearch-Contract#:290-02-0025Sub#12-P3039939

02/01/05-08/31/05($44,000)Investigator

SubcontractforDevelopmentofaMonographontheDevelopmentandApplicationofRegistries(EPCII/CPTA)[AgencyforHealthCarePolicyandResearch-Contract#:290-02-0025,Sub#11-P3039939]

01/05–01/08R812,000

AStudyofPracticePatternsinUnstableAnginainSecondaryandTertiaryHealthCareSetupinandAroundNagpur(CentralIndia)[Pfizer,Dr.PrashantJagtap,MD,DM,FACC,PI]EvaluateandimprovetheconcordancebetweenthemanagementofunstableanginainsecondaryandtertiaryhealthcarecentersandtheACC/AHAguidelineforunstableangina.

33

11/01/04-05/31/07($250,000)PrincipalInvestigator

JudgingTheValueOfNewTherapiesForTheCareOfPatientsWithChronicKidneyDisease:DevelopingandApplyingAComprehensiveModel-basedApproach[AbbottLaboratories]Developanadvancedchronickidneydiseasepharmacoeconomicmodelasapubliclyavailablerepositoryofbestepidemiologicalevidence,whichcanbeusedtoevaluatethedevelopmentandoutcomesofadvancechronickidneydisease.

10/01/04-09/30/06($138,212)PrincipalInvestigator

DevelopmentofaPublicUseSimulationModelofStrokeinSupportofInformedStatePolicy-making[CentersforDiseaseControlandPrevention-Contract#:MM-0919-05/05]RevisetheDSPMtoincorporatestatelevelinformationandtogeneratestate-levelestimatesoftheburdenofdiseaseandtheimpactofnewpublichealthinitiatives.Thoughthiscanbeappliedtoawidevarietyofprogramsandregions,wewillinitiallyfocusonimprovementofhypertensioncontrolinthestateofMississippi.ThisprojectwillbedoneincollaborationwiththeCentersforDiseaseControl,CardiovascularHealthBranch,theMississippiHealthPolicyCenter,andDr.GeorgeHoward,aleadingstrokeepidemiologistatUniversityofAlabama,Birmingham.

07/04/04-07/31/06($285,000)Investigator

Aproposaltopilottesttheadvancedchronickidneydiseasepracticeimprovementtoolbox[RenalPhysiciansAssociation-PI:Patwardhan]Understand(a)existingpracticepatternsforpatientswithadvancedCKDacrosstheUSbyspecialty,and(b)thesocio-economicandheathcareenvironmentinwhichACKDpatientsaremanaged

07/01/04-09/30/05($58,000)PrincipalInvestigator

Devices(EPCII/CPTA)[AgencyforHealthCarePolicyandResearch-Contract#:290-02-0025,Sub#5-P3039939]

04/01/04-03/15/05($19,481)PrincipalInvestigator

DevelopingaMethodologyforEstablishingaStatementofWorkforaPolicyRelevantTechnicalAnalysis[AgencyforHealthCarePolicyandResearch-Contract#:290-02-0025]DevelopadraftmethodologyforestablishinganoptimalSOWforapolicy-relevanttechnicalanalysis.

02/20/04-01/31/10($238,000)Investigator

HypertensionImprovementProject(HIP)(NationalInstitutesofHealth-Contract#5R01-HL-075373-05)Arandomized,controlledtrialthatwilltesttheseparateandcombinedeffectsonBPcontrolofacontinuousqualityimprovement(CQI)interventionforphysiciansandabehavioralinterventionforpatients.

02/20/04-01/31/09($2,191,761)Investigator

HypertensionImprovementProject(HIP)[NationalInstitutesofHealth-Contract#(PI):1R01-HL-075373(Svetkey)]Arandomized,controlledtrialthatwilltesttheseparateandcombinedeffectsonBPcontrolofacontinuousqualityimprovement(CQI)interventionforphysiciansandabehavioralinterventionforpatients.

10/01/03-09/30/07($1,874,833)Investigator

Pharmacogenetics,Biomarkers,andAntithromboticTherapy[IH/NationalHeart,Lung,andBloodInstitute(NHLBI)-Contract#(PI):1R01-HL-074724(Gage)]Improvethesafetyandtheeffectivenessofanticoagulanttherapy.

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09/30/03-09/29/07($1,038,960)($awardedperTO)PrincipalInvestigator

Evidence-basedPracticeCenter(EPC)TechnicalSupportoftheCenterforPracticeandTechnologyAssessment(CPTA)TechnologyAssessmentProgram[AgencyforHealthCarePolicyandResearch-Contract#:290-02-0025]ProvidetechnicalsupportfortheCentersforMedicareandMedicaidServices(CMS)TechnologyAssessmentProgram(TAP).Includesvarioustopicscoveringdevices,proceduresandotherpractices.

09/30/03-08/31/07($1,907,894)Investigator

ImprovingtheQualityofDiabetesEyeCare[NationalInstitutesofHealth,PI:PaulLee]Evaluatenewstrategiesforimprovingdiabeticeyecareamongcommunity-basedproviders(ophthalmologistsandoptometrists).

03/01/03-05/30/05($134,307)Investigator

AmericanHeadacheSociety(AHS)–PrimaryCareMigrainePartnership(PCMP)OutcomeMeasurementAssessment[AmericanHeadacheSociety;PI:Patwardhan]EvaluatetheimpactoftheAHS-PCMPheadacheeducationalprogramonphysicianbeliefs,knowledge,andpractice.

01/02/03-02/14/04($226,306)PrincipalInvestigator

CriteriatoDetermineDisabilityrelatedtoMultipleSclerosis[AgencyforHealthCarePolicyandResearch-Contract#:290-02-0025]DevelopanEPCevidencereport“CriteriatodeterminedisabilityrelatedtoMultipleSclerosis”.ThereportisrequestedbytheSocialSecurityAdministration.

12/01/02-12/01/03($99,915)Investigator

DukeAnticoagulationSatisfactionSurvey(DASS)ReliabilityStudy[AstraZenecaPharmaceuticals-PI:Samsa]Assesstest-retestreliabilityofanewinstrumentmeasuringsatisfactionwithanticoagulation

09/01/02-09/29/03($64,910)PrincipalInvestigator

ImprovingInterventionModuleforStrokePolicyModel(AHRQ-SmallGrant)[AgencyforHealthCarePolicyandResearch-Contract#:1RO3-HS-11746]Developaninterventionlanguagebywhichstrokeprevention,treatmentandrehabilitationinterventionscanbeeasilyaddedtotheStrokePolicyModel.

6/17/02-09/29/07($awardedperTO)Co-Director

Evidence-basedPracticeCentersII[AgencyforHealthCarePolicyandResearch#290-02-0025]Costreimbursementtaskordercontract

04/01/02-12/31/09($13million)PrincipalInvestigator

TheHomeINRStudy(THINRS)[VACooperativeStudy#481]A28-site,3000patientrandomizedcontrolledtrialofthepatientself-testing(PST)ofprothrombintimebyinternationalnormalizedratio(PTINR)withweeklytestingcomparedtohighqualityanticoagulationmanagement(HQACM)providedinananticoagulationclinicwithconventionalmonthlytesting.

35

01/01/02-12/01/02($550,512)Investigator

DukeCentertoEliminateRacialHealthDisparities.TestingRaceSensitiveStrategiestoImprovePatientandPhysicianControlofHypertension[DukeUniversity-PI:Svetkey]Examinetheindividualandinteractiveeffectsofanintensivedietaryeducation,lifestylemodification,motivationalcounselingforpatientswithstage1or2hypertensionandatrainingandCQIprogramfortheirphysiciansasstrategiestooptimizetheadherenceofemergingracialminoritiesandpersonslivinginpovertytoareduced-sodiumDASHdiet.Thefindingsfromthisproposalwillofferquantitativesupportforamulti-facetedpatient/providerapproachtoenhancingpatientadherencetobeneficiallifestylealterationsthatreduceBP.

01/01/02-10/30/02($49,999)PrincipalInvestigator

ReportontheEpidemiologyAndCostofMultipleSclerosis[BristolMyersSquibb]EstimatetheoverallburdenofMS,intermsofmortality,qualityoflifeandeconomiccost;andthelikelyreductionintheburdenthatcouldbeachievedbyBMS’snewdrug.Thisestimationcanbestbemadethroughacost-effectiveness(CEA)model.

09/30/01-09/29/06($1,208,292)PrincipalInvestigator

ARandomizedTrialofHeadacheManagementPrograms[NationalInstitutesforHealth(NIH)/AHRQ-Contract#:5R01-HS-10893]Determinewhetherheadachemanagementprogramsshouldbepromotedasaneffectiveandcost-effectivestrategyformanagingpatientswithchronicdisablingheadache.K24

07/02/01-02/28/02($149,848)PrincipalInvestigator

TheUseofPositronEmissionTomography(PET)andOtherNeuroimagingTechniquesintheDiagnosisandManagementofAlzheimer’sDiseaseandDementia[AgencyforHealthcareResearchandQuality-Contract#(co-PI):290-97-0014,TO#8(McCrory)]FocusontheissueofmedicalbenefitofPETscanning,inadditiontoastandardevaluationincludingaclinicalexaminationandstructuralneuroimaging,forindividualswhomayhaveAlzheimer’sdisease(AD)incomparisonwithotherevaluationstrategiesthatarecurrentlycoveredbyMedicare.TheevidencewaslinkedthroughtheuseofaMarkovmodelwhichprovidesprojectionsofavarietyofimportantclinicaloutcomes.ThereportwaspresentedtotheMedicareCoverageAdvisoryCommitteetoaidintheirdeliberationsaboutcoverage.

02/01/01-05/30/03($37,800)PrincipalInvestigator

CanadianStrokePolicyModel[CanadianStokeNetwork-CoPI:Nichol]DevelopaCanadianversionoftheStrokePolicyModel.

01/01/01-12/31/02($203,306)Investigator

ModelingtheEffectivenessandCost-effectivenessofanHPVVaccine[Merck-PI:Myers]Developandvalidateageneralmodelforevaluatingthecost-effectivenessofanHPVvaccineandtomakethegeneralmodelavailabletothepublicontheWorldwideWeb.

12/01/00-06/30/02($124,734)Investigator

DevelopmentofaNewAnticoagulationInstrument,PhaseII[AstraZenecaPharmaceuticals-PI:Samsa]Validateaninstrument,theDukeAnticoagulationSatisfactionScale(DASS)toassesstheburdenoftreatmentinaclinicaltrialofanewanticoagulationagentversuswarfarin.

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10/01/00-09/30/02($280,250)PrincipalInvestigator

DevelopmentofClinicalPracticeGuidelinesforImprovingtheQualityofCareofVeteranswithMultipleSclerosis[ParalyzedVeteransofAmerica]ProvidemethodologicalexpertiseandconductsystematicreviewsandsynthesisofthescientificliteraturetodevelopClinicalPracticeGuidelinesforimprovingqualityofcareofpatientswithmultiplesclerosis.Atpresentthereareevidencereportsandguidelinesbeingdevelopedonseveralsub-topicsofmultiplesclerosis;spasticity,immunizations,disease-alteringtherapies,andpregnancy.

09/01/00-02/28/02($249,864)Investigator

ManagementofPost-TermPregnancy[AgencyforHealthcareandQualityResearch-Contract#290-97-0014,TO#6(PI-Myers)]Address four key issues on management of post-term pregnancy. 1) The available evidence oneffectiveness of fetal measures in antenatal surveillance, 2) The relative effectiveness of plannedinductionvsexpectantmanagement,3)Therelativeeffectivenessof thecurrentlyavailable inductionagents,and4)Effectivenessbyrace,ethnicity,orincomelevel.

08/01/00-06/30/01($50,000)PrincipalInvestigator

TechnicalAssistancetotheMoscowMedicalAcademy[AgencyforHealthcareResearchandQuality-Contract#:290-97-0014(TO#5)]Providetechnicalassistancetothenewly-establishedMoscowMedicalAcademyEvidence-basedCenter(MMACenter).Thiswillincludeon-sitetrainingofhealthprofessionalsintheMMACenter.TechnicalassistancewillrelatetoguidanceonestablishingaRussianexpertpaneltoassisttheCenterinundertakingsystematicreviews,reviewingforaccuracy,translationsperformedbythecenterstaff,guidanceonconductingexternalpeerreviewinRussiabyRussianprofessionalcolleagues,ofdraftMMACenterreportsorguidelines.

07/01/00-09/30/02($351,711)PrincipalInvestigator

ClinicalPracticeGuidelinesonAppropriatePatientPreparationforRenalReplacementTherapy[RenalPhysiciansAssociation]Developanevidencereportthatprovidesevidenceofbestclinicalpracticesformanagementofthemanyhealthissuesrelatedtopreparationforrenalreplacementtherapy.

12/01/99-08/30/02($141,661)Investigator

TheEffectivenessofInvoluntaryOutpatientCommitment(NIMH)[NIMH-PI:Swartz]AddresstheprioritiesoutlinedintheNIMHNationalAdvisoryMentalHealthCouncil'sClinicalTreatmentandServicesWorkgroupReport,"BridgingScienceandService".

10/01/99-09/30/00($25,000)PrincipalInvestigator

UseoftheEPCUterineFibroidsModeltoExploreClinicalTreatmentDecisions[AgencyforHealthCarePolicyandResearch-Contract#:290-97-0014,TO#4]DevelopanevidencereportonmanagementofuterinefibroidsforuseindevelopmentofclinicalpracticeguidelinesbytheAmericanCollegeofObstetricians&Gynecologists

10/01/99-07/31/00($57,510)PrincipalInvestigator

SystematicReviewofControlledTrialsofBehavioralandPhysicalTreatmentsforTension-TypeandCervicogenicHeadache[FoundationforChiropracticResearchandEducation]

09/01/99-09/30/99($10,486)PrincipalInvestigator

EconomicImpactofStrokeinNorthCarolina,SouthCarolinaandGeorgia[NCDept.ofHealthandHumanServices]

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08/16/99-06/30/00($36,332)PrincipalInvestigator

DevelopaNewAnticoagulationInstrument[AstraPharmaceuticals]Developaninstrumenttoevaluatetheimpactofanticoagulation:limitations,risksandmanagement.Thisinstrumentwillultimatelybeusedtoassesstheburdenoftreatmentinclinicaltrialsofalternativemodelsofanticoagulation.

07/01/99-06/30/04($190,031)PrincipalInvestigator

RPAImplementationofClinicalPracticeGuidelinesforAdvancedCKDPatients[RenalPhysiciansAssociation]Developtoolsforimprovingcareofpatientswithadvancedchronickidneydisease(GFR<30,notyetonrenalreplacement).

06/01/99-12/30/99($50,000)PrincipalInvestigator

DevelopmentofaUser-FriendlyModeloftheHealthandEconomicImpactofStroke[KnollPharmaceuticals]Createanuser-friendlyweb-basedversionoftheStrokePolicyModelthatwouldbenefitprivatephysician,clinicians,andmanagersinmedicalcenter,managedcareorganizations,theinsuranceindustry,researches,aswellaspharmaceuticalcompanies.

04/01/99-03/31/00($227,886)PrincipalInvestigator

EvidenceReport:TreatmentofPulmonaryDiseaseFollowingSpinalCordInjury[AgencyforHealthCarePolicyandResearch-Contract#(CoPI):290-97-0014,TO#3(McCrory)]Developaninitialdraftofaconceptualmodeltoassistthinkingindeterminingwhenandhowitisappropriatetoapplyevidencefromnon-randomizeddesignswithinevidencereportsandotherinformationsynthesisapplications;illustratetheuseofthisconceptualmodelasappliedtoacasestudyfromanEPCevidencereportinspinalcordinjury(SCI);andproduceawhitepaperand/orjournalarticledescribingtheresultsofourresearch.

10/01/98-09/30/99($198,213)Investigator

ManagementofAcuteExacerbationsofChronicObstructivePulmonaryDisease(COPD)[AgencyforHealthCarePolicyandResearch-Contract#(PI):290-97-0014,TO#2(McCrory)]Developanevidencereportonthemanagementofacuteexacerbationsofchronicobstructivepulmonarydisease.

05/01/98-05/01/00(162,000)Investigator

ImprovingQualityofCareThroughaMultidisciplinaryHeadacheManagementService[AetnaUSHealthcare]Identify,pilotandultimatelytestthedevelopmentofaheadachemanagementserviceinarandomizedtrial.

10/01/97-01/15/98($112,410)PrincipalInvestigator

AcuteStrokeTreatmentModelforLubeluzole:FASTModeL[JanssenPharmaceutical]Developan“user-friendly”versionofthelubeluzolecost-effectivenessmodelthatillustratesthehealthandimpactoflubeluzoleforspecifictypesofpatients,aswellaspopulations.

07/01/97-12/31/98($55,575)Investigator

TheEconomicAnalysisoftheTrasylolClinicalTrials[BayerCorporation]Performanindependentandcomprehensiveanalysisofthecost-effectivenessofTrasylol.

05/1/97-01/31/02($341,600)PrincipalInvestigator

DukeHealthOutcomesPolicyWorkingGroup[PfizerPharmaceuticals]Supportresearchinhealthoutcomesthroughindustry/academiccollaborations.

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1997-1998($38,218)Investigator

DeterminingtheMinimalClinicallySignificantDifferenceintheHealthUtilityIndex[JanssenResearchFoundation]

1996-2001($4,039,315)Consultant

CPRU:ImprovingCancerRiskCommunication[NationalInstitutesofHealth]Studywaysofimprovingcommunicationofinformationaboutcancerrisk.

1996-2000($116,656)Investigator

EffectsofPublicSubsidiesonUseofLongTermCare[NationalInstituteonAging]

1996-1999($186,844)Investigator

Interactive,Guideline-BasedDecisionSupportontheWeb[AgencyforHealthCarePolicyandResearch]

04/01/96-04/30/97($66,496)PrincipalInvestigator

EvaluationofHealthandEconomicImpactofAcuteStrokeTreatment[G.D.SearleandCompany]

12/01/95-06/30/02($1,010,687)PrincipalInvestigator

ARandomizedTrialofAnticoagulationServicesforStrokePrevention[DuPontMerck]Performarandomizedtrialtoassesstheeffectivenessandcost-effectivenessofACSsinimprovinganticoagulationmanagementforpatientswithAF.

1994-1998($167,292)PrincipalInvestigator

EvidenceReport:EvaluationofAbnormalCervicalCytology[AgencyforHealthCarePolicyandResearch]

1994-1998($843,463)PrincipalInvestigator

EvidenceReport:ChronicPain--Headache[AgencyforHealthCarePolicyandResearch]

1994-1998($1,511,900)PrincipalInvestigator

ClinicalManagementandOutcomesofVeteranswithStrokeatVAMCs[DepartmentofVeteransAffairs]

1994-1996($1,104,699)PrincipalInvestigator

DevelopmentandPeriodicUpdatingofClinicalPracticeGuidelines,MedicalReviewCriteria,StandardsofQualityandPerformanceMeasuresonChronicPain:Headache[AgencyofHealthCarePolicyandResearch]

1994(1year)($9,750)Investigator

RadioisotopeDilutionAssay(RIDA)forB12,MethylmalonicAcidExcretionandClinicalCriteriaintheDiagnosisofB12Deficiency[DepartmentofVeteransAffairs]

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1992-1995($599,806)Investigator

ClinicalPracticeGuidelinesforUnstableAngina[AgencyforHealthCarePolicyandResearch]

1992-1994($45,390)Investigator

DevelopingEfficientStrategiesforManagingSinusitis:ARandomizedTrial[DepartmentofVeteransAffairs/HealthServicesResearch/SmallProjectProgram]

10/01/91-09/30/92($70,000)PrincipalInvestigator

HealthandEconomicsOutcomesProgram[PfizerPharmaceuticals]

09/30/91-09/30/00($689,314)PrincipalInvestigator

SupplementtoSecondaryandTertiaryPreventionofStrokePORT[AgencyforHealthCarePolicyandResearch]

09/30/91-09/29/96($5,627,836)PrincipalInvestigator

SecondaryandTertiaryStrokePreventionPORT[AgencyofHealthCarePolicyandResearch]

1991-1994($869,798)Investigator

CareofCriticallyIllHospitalizedAdults[RobertWoodJohnsonFoundation]

01/01/91-06/30/93($75,000)PrincipalInvestigator

ImprovingMethodsforDevelopingAppropriatenessCriteria[AcademicMedicalCentersConsortium]

07/01/90-06/30/93($28,000)PrincipalInvestigator

InitiativetoImprovetheEfficacyofMedicalCare[AcademicMedicalCentersConsortium]

01/01/90-12/31/92($41,000)PrincipalInvestigator

ImprovingConsensusinClinicalGuidelineDevelopment[AcademicMedicalCentersConsortium]

40

09/01/89-02/01/90($33,333)PrincipalInvestigator

CerebralVascularDisease:OptimizingPatientCare[NationalCenterforHealthServicesResearch]

1988-1989($10,000)Investigator

ARapidTestofLanguageFunction:TheQAT[A.W.MellonFoundation]

1988-1989($50,000)CoreLeader

PredictingOutcomesforVentilatedPatientsintheMedicalIntensiveCareUnit[VeteransAdministrationCooperativeStudies]

1987-1988($9,890)Consultant

PredictingOutcomeofInvasiveStudiesinPatientswithSyncope[A.W.MellonFoundation]

1986-1989($290,304)PrincipalInvestigator

InfluenceofHyperglycemiaonOutcomeofCerebralInfarction[NationalInstituteforNeurologicandCommunicativeDiseasesandStroke]

TrainingandCareerGrants:1992-1993($1,865,757)TrainingFellowship

GeriatricResearchandTrainingCenters[NationalInstitutesonAging]

1991-1993TrainingFellowship

AModelofPatientPreferencesinSeriousIllness[AgencyforHealthCarePolicyandResearch]

1990-1994($132,256)ResearchFellowship

CerebrovascularResearchTrainingProgram[NationalInstitutesofHealth]

1984($4,000)TrainingFellowship

ClinicalDecisionAnalysis[A.W.MellonFoundation]

1984($2,000)TrainingFellowship

Ciba-CorningMedical

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PersonalInformation:Preferredfirstname:

David

BusinessContactInformation:

Duke-NUSMedicalSchoolSingapore8CollegeRoadSingapore169857Phone:(65)65162584;Fax:(65)65348632;Email:david.matchar@duke-nus.edu.sg