CV-Keith M. Erikson

Curriculum Vitae

Name: Keith M. Erikson updated 7/18Email: kmerikso@uncg.edu

335 Stone BuildingDepartment of Nutrition University of North Carolina Greensboro Greensboro, NC 27402(336) 256-0327

Education:

Postdoctoral Research Fellow, Wake Forest University School of Medicine, 2001-2003Ph.D. in Nutrition, The Pennsylvania State University, December 2000M.S. in Nutrition, The Pennsylvania State University, May 1997B.A. in Physical Education, Cedarville College, 1986

Employment:

Professor, Dept. of Nutrition. University of North Carolina Greensboro. 2018-present.Associate Professor. Dept. of Nutrition. University of North Carolina Greensboro. 2009-2018.Assistant Professor, Dept. of Nutrition, University of North Carolina Greensboro, 2003-2009.Postdoctoral Research Associate, Dept. Physiology/Pharmacology, Wake Forest University School of Medicine, 2001-2003.Lecturer, Dept. of Nutrition, University of North Carolina Greensboro, Fall 2000.

Publication Statistics from Google Scholar

Citation indices All Since 2013Citations 4973 2347h-index 41 30i10-index 58 54

Journal Publications: (*denotes graduate student; # denotes undergraduate student)

Hubler, M., Erikson, K.M., Kennedy, A., Hasty, A. (2018) MFehi adipose tissue macrophages compensate for tissue iron pertubations in mice. A.J.P. Cell Physiol.

Han, J., *Plummer, J., *Lui, L., *Byrd, A., Aschner, M. and Erikson, K.M. (2017) The impact of obesity on brain iron levels and alpha synuclein expression are regionally dependent. Nutritional Neuroscience, DOI: 10.1080/1028415X.2017.1387720

Aschner, M. and Erikson, K.M. (2017) Manganese. Advances in Nutrition 8:520-521.

*Lui, L, *Byrd, A, *Plummer, J, Erikson, KM, Harrison, SH, Han, J. (2016) The Effects of Dietary Fat and Iron Interaction on Brain Regional Iron Contents and Stereotypical Behaviors

CV-Keith M. Erikson

in Male C57BL/6J Mice. Frontiers in Nutr., Animal Nutr and Metab.Vol. 3 Article 20.

Vorhees CV, Graham DL, Amos-Kroohs RM, Braun AA, Grace CE, Schaefer TL, Skelton MR, Erikson KM, Aschner M, Williams MT. (2014) Effects of developmental manganese, stress and the combination of both on monoamines, growth and coricosterone. Toxicol Rep. 1:1046-1061.

Aboud AA, Tidball, AM, Kumar, KK, Neely, MD, Han, B, Ess, KC, Hong, CC, Erikson, KM, Hedera, P, Bowman, AB (2014) PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper Neurobiology of Disease 73C:204-212. 

*Fordahl, SC and Erikson, KM. (2014) Manganese Accumulation in membrane fractions of primary astrocytes is associated with decreased GABA uptake, and is exacerbated by oleic acid and palmitate. Environ Toxicol Pharmacol 37: 1148-1156.

Orr JS, Kennedy A, Anderson-Baucum EK, Webb CD, *Fordahl SC, Erikson KM, Zhang Y, Etzerodt A, Moestrup SK, Hasty A (2014). Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes 63:421-432.

Cordova FM, Aguiar AS Jr, Peres TV, Lopes MW, Gonçalves FM, Pedro DZ, Lopes SC, Pilati C, Prediger RD, Farina M, Erikson KM, Aschner M, Leal RB (2013 )Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox. Arch Toxicol 87(7):1231-1244.

Aboud AA, Tidball AM, Kumar KK, Neely MD, Ess KC, Erikson KM, Bowman AB. (2012) Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects. Neurotoxicology. 33(6):1443-1449.

Criswell, S., Perlmutter, J., Huang, J., Golchin, N., Flores, H., Hobson, A., Aschner, M., Erikson, K., Racette, B. (2012) Basal Ganglia Intensity Indices and Diffusion Weighted Imaging in Manganese Exposed Welders. Occupational and Environmental Medicine 69(6): 437-443.

Cordova, F., Aguiar-Jr, A., Peres, T., Lopes, M., Goncalves, F., Remor, A., Lopes, S., Pilati, C., Latini, A., Prediger, R., Erikson, K., Aschner, M., Leal, R., (2012) In vivo manganese exposure modulates ERK, AKT and DARPP-32 in the Striatum of Developing Rats, and Impairs their Motor Function. PLoS One 7(3): e33057.

Avila, D.S., Benedetto, A., Au, C., Manarin, F., Erikson, K., Soares, F.A., Rocha, J.B., Aschner, M. (2012) Organotellurium and Organoselenium compounds attenuate Mn-induced toxicity in C. elegans by preventing oxidative stress. Free Radic Biol Med 52(9): 1903-1910.

*Fordahl, S.C., Cooney, P.T., Qiu, Y., Xie, G, Jia, W., Erikson, K.M. (2012) Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors. J. Neurotox and Teratol 34: 27-36.

Fitsanakis, V.A., Zhang, N., Avison, M.J., Erikson, K.M., Gore, J.C., Aschner, M. (2011) Changes in Dietary Iron Exacerbate Regional Brain Manganese Accumulation as Determined by Magnetic Resonance Imaging (MRI). Tox Sci 120(1): 146-153.

*Fordahl, S.C., *Anderson, J.G., Cooney, P.T., Weaver, T.L., Colyer, C.L., Erikson,

K.M. (2010) Manganese exposure Inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats. Neurotoxicology 31: 639-646.

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Williams, B.B., Kwakye, G.F., Wegrzynowicz, M., Li, D., Aschner, M., Erikson, K.M., Bowman, A.B. (2010) Altered manganese homeostasis and manganese toxicity in Huntington’s Disease striatal cell model are not due to defects in iron transport system. Tox Sci 117:169-179.

Yin, Z., Jiang, H., Lee, E. Ni, M., Erikson, K.M., Milatovic, D., Bowman, A., Aschner, M. (2010) Ferroportin is a manganese responsive protein that decreases manganese cytotoxicity and accumulation. J. Neurochem 112 (5):1190-1198.

Williams, B.B., Vadodaria, B.K., *Anderson, J.G., Kwakye, G.F., Li, D., Aschner, M., Erikson, K.M., Bowman, A.B. (2010) Altered Manganese Homeostasis in Huntington’s Disease. J Neurochem 112 (1):227-237.

Au, C., Benedetto, A., *Anderson, J., Labrousse, A., Erikson, K., Ewbank, J.J., Aschner, M. (2009) SMF-1, SMF-2, SMF-3 DMT-1 orthologues regulate and are regulated differentially by manganese levels in C. Elegans. PLoS One. Nov 18;4(11):e7792.

Aschner, M., Erikson, K.M., Herrorro Hernandez, E., Tjalkens, R. (2009) Manganese and its Role in Parkinson's disease: from Transport to Neuropathology. NeuroMolecular Med; 11:252-266.

*Messer, J.G., *Kilbarger, A.K., Erikson, K.M., Kipp, D.E. (2009) Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures. Bone 45: 972-999.

*Anderson, J.G., *Fordahl, S.C., Cooney, P.T., Weaver, T.L., Colyer, C.L., and Erikson, K.M. (2009) Extracellular Norepinephrine, Norepinephrine Receptor and Transporter Protein and mRNA Levels Are Differentially Altered in the Developing Rat Brain Due to Dietary Iron Deficiency and Manganese Exposure. Brain Res 1281:1-14.

Fitsanakis, V.A., Thompson, K.N., Deery, S.E., Milatovic, D., Shihabi, Z.K, Erikson, K.M., Brown, R.W., Aschner, M. (2009) A chronic iron deficient/high-manganese diet in rodents results in increased brain oxidative stress and behavioral deficits in the morris water maze. Neurotox Res 15:167-178.

Carneiro, A.M., Airey, D.C., Thompson, B., Zhu, C.B., Lu, L., Chesler, E.J., Erikson, K.M., Blakely, R.D. (2009) Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Proc Natl Acad Sci U.S.A. 106:2047-2052.

Zhang, N., Fitsanakis, V.A., Erikson, K.M., Aschner, M., Avison, M.J., Gore, J.C. (2009) A Model for the Analysis of Competitive Relaxation Effects of Manganese and Iron in Vivo. NMR in Biomedicine 22:391-404.

PROMOTED TO ASSOCIATE PROFESSOR-2009*Anderson, J.G., #Fordahl, S.C., Cooney, P.T., Weaver, T.L., Colyer, C.L., and Erikson,

K.M. (2008) Manganese exposure alters extracellular GABA, GABA receptor and transporter protein and mRNA levels in the developing rat brain. Neurotoxicology Nov;29(6):1044-53.

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Erikson, K.M., Dorman, D.C., Lash, L.H., Aschner, M. (2008) Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity. Neurotoxicology 29:377-385.

Fitsanakis, V.A., Zhang, N., *Anderson, J.G., Erikson, K.M., Avison, M.J., Gore, J.C., Aschner, M. (2008) Measuring Brain Manganese and Iron Accumulation in Rats Following 14-weeks of Low-Dose Manganese Treatment Using Atomic Absorption Spectroscopy (AAS) and Magnetic Resonance Imaging (MRI). Toxicol. Sci 103:116-124.

Gellein, K., Flaten, T.P., Erikson, K.M., Aschner, M., Syversen, T. (2008) Leaching of trace elements from biological tissue by formalin fixation. Biol Trace Elem Res. 121:221-225.

Erikson, K.M., Dorman, D.C., Lash, L.H., Aschner, M. (2007) Manganese Inhalation by Rhesus Monkeys is Associated with Brain Regional Changes in Biomarkers of Neurotoxicity. Tox Sci. 97:459-466.

Erikson, K.M., Thompson, K., Aschner, J., and Aschner, M. (2007) Manganese Neurotoxicity: A Focus on the Neonate. Pharmacol and Therap. 113:369-377.

*Anderson, J.G., Cooney, P.T., Erikson, K.M. (2007) Brain Manganese Accumulation is Inversely Related to GABA Uptake in Male and Female Rats. Toxicol. Sci.95: 188-195.

*Anderson, J.G., Cooney, P.T., Erikson, K.M. (2007) Inhibition of DAT function attenuates manganese accumulation in the globus pallidus Environ Tox and Pharmacol 23:179-184.

Fitsanakis, V.A., Erikson, K.M., Garcia, S.J., Evje, L., Syversen, T., Aschner, M. (2006) Brain Accumulation of depleted uranium in rats following 3 or 6 month treatment with implanted depleted uranium pellets. Biol Trace Elem Res 111: 185-197.

Taylor, M.D., Erikson, K.M., Dobson, A.W., Fitsanakis, V., Dorman, D.C., and Aschner, M. (2006) Effects of Inhaled Manganese on Biomarkers of Oxidative Stress in the Rat Brain. Neurotoxicology 27:788-797

Erikson, K.M., Dorman, D.C., Fitsanakis, V., Lash, L.H., Aschner, M. (2006) Alterations of oxidative stress biomarkers due to In utero and neonatal exposures of airborne manganese. Biol Trace Elem Res 111:199-215

Dobson, A.W., Lack, A.K., Erikson, K.M. and Aschner, M. (2006) Depleted uranium is not toxic to rat brain endothelial (RBE4) cells. Biol Trace Elem Res 110(1): 61-72.

Fitsanakis, V.A., Au, Catherine, Erikson, K.M., Aschner, M. (2006) The effects of manganese on glutamate, -aminobutyric acid, and dopamine regulation. Neurochem. Intl. 48(6-7): 426-433.

Erikson, K.M., and Aschner, M. (2006) Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology 27:125-130.

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Erikson, K.M., John, C.E., Jones, S.R., Aschner, M. (2005) Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter. Environ Toxicol Pharmacol. 20:390-394.

Erikson, K.M., Dorman, D.C., Lash, L., Aschner, M. (2005) Persistent alterations in biomarkers of oxidative stress due to combined in utero and neonatal manganese inhalation. Biol Trace Elem Res. 104(2):151-164.

Erikson, K.M., Syversen, T., Aschner, J.L., and Aschner M. (2005) Interactions between excessive manganese-exposure and dietary iron-deficiency in neurodegeneration. Environ. Toxicol. Pharmacol. 19:415-421.

Aschner, M., Erikson, K.M., and Dorman, D.C. (2005) A Review of Manganese Toxicokinetics. Critical Reviews in Toxicology. 35:1-32.

Erikson, K.M., Dobson, A.W., Dorman, D.C., and Aschner, M. (2004) Does Manganese Induce Oxidative Stress in the Rat Brain? Science and the Total Environment. 334-335:409-416.

Erikson, K.M., Dorman, D.C., Lash, L.H., Dobson, A.W., and Aschner, M. (2004) Airborne manganese exposure differentially affects endpoints of oxidative stress in an age and sex-dependent manner J Biol Trace Elem. 100:49-62.

Erikson, K.M., Syversen, T., Steinnes, E., and Aschner, M. (2004) Globus Pallidus: A target brain region for divalent metal accumulation due to dietary iron deficiency. J Nutr Biochem 15:335-341.

ASSISTANT PROFESSORSHIP BEGAN

Dobson, A.W., Erikson, K.M., and Aschner, M. (2004) Manganese Neurotoxicity. Ann NYAS, 1012:115-129.

Dobson, A.W., Weber, S., Dorman, D.C., Lash, L.K., Erikson, K.M., and Aschner, M. (2003) Oxidative Stress is Induced in the Rat Brain Following Repeated Inhalation Exposure to Manganese Sulfate. Biol Trace Elem Res 93(1-3) 113-126.

Erikson, K.M. and Aschner, M. (2003) Manganese neurotoxicity and GABA/glutamate interactions. Neurochem Intl 43(4-5):475-480.

Beard, J.L., Erikson, K.M., and Jones, B.C. (2003) Lactational iron deficiency results in irreversible changes in dopamine metabolism in the rat. J Nutr 133(4):1174-1179.

Erikson, K.M. and Aschner, M. (2002) Manganese causes differential regulation of glutamate transporter (GLAST), taurine transporter, and metallothionein in cultured rat astrocytes. Neurtoxicology 23(4-5): 595-602.

Erikson, K.M., Suber, R.L., and Aschner, M. (2002) Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate. Neurotoxicology 23(3): 281-288.

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Weber, S., Dorman, D.C., Lash, L.H., Erikson, K., Vrana, K.E., and Aschner, M. (2002) Effects of Manganese on the developing rat brain: oxidative-stress related endpoints. Neurotoxicology 23(2): 169-175.

Aschner, M., Shanker, G., Erikson K., Yang, J., and Mutkus, L.A. (2002) The uptake of manganese in brain endothelial cultures. Neurotoxicology 23(2): 165-168.

Beard, J.L., Erikson, K.M., and Jones, B.C. (2002) Neurobehavioral analysis of developmental iron deficiency in rats. Behav Brain Res 134: 517-524.

Erikson, K.M, Shihabi, Z.K., Aschner, J.L., Aschner, M. (2002) Manganese accumulates in iron deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations. Biol Trace Elem Res 87(1-3): 143-156.

Gerhard, G.S., Kaufmann, E.J., Wang, X., Erikson, K.M., Abraham, J., Grundy, M., Beard, J.L., and Chorney, M.J. (2002) Genetic differences in hepatic lipid peroxidation potential and iron levels in mice. Mech. of Age. and Develop. 123: 167-176.

Erikson, K.M., Jones, B.C., Hess, E.J. and Beard, J.L. (2001) Altered functioning of dopamine D1 and D2 receptors in brains of iron deficient rats. Pharmacol. Biochem. Behav. 69:409-18.

Erikson, K.M., Jones, B.C. and Beard, J.L. (2000) Iron deficiency alters dopamine transporter functioning in rat striatum. J. Nutr. 130(11):2831-2837.

Rosales, F.J., Jing-Tsz, J., Pinero, D.J., Erikson, K.M., Beard, J.L. and Ross, A.C. (1999) Iron Deficiency in young rats alters the distribution of Vitamin A between plasma and liver, and between retinol and retinyl esters. J. Nutr. 129:1223-1228. Erikson, K.M., Beard, J.L. and Connor, J.R. (1998) Distribution of brain iron, ferritin and transferrin in the 28 day old piglet. J. Nutr. Biochem. 9:276-284.

Nelson, C.L., Erikson, K.M., Pinero, D.J. and Beard J.L. (1997) In vivo dopamine metabolism in iron deficiency anemia. J. Nutr. 127:2282-2288. Erikson, K.M., Pinero, D.J., Connor, J.R. and Beard, J.L. (1997) Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J. Nutr. 127:2030-2038.

Book Chapters

Erikson, K.M. and Aschner M. (2018) Manganese . Metal Ions in Life Sciences, published by Walter de Gruyter GmbH, Berlin, Germany (www.bioiorganic-chemistry.org/mils)

Fordahl, S.C. and Erikson, K.M. (2011) The Neurochemical Consequences of Manganese Neurotoxicity. Metal Ions and Stroke. Ed. Zhang, J. and Li, Y. Springer Press

Erikson, K.M. (2010). You are what you eat. The Dole Nutrition Handbook What to eat and how to live for a longer, healthier life. The Dole Nutrition Institute.

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Anderson, J.G. and Erikson, K.M. (2009) The importance of trace elements for neurological functioning. The Handbook of Behavior, Diet and Nutrition. Ed. Victor R. Preedy. Springer Press

Bowman, A.B., Erikson, K.M., and Aschner, M. (2008) Manganese: The two faces of essentiality and toxicity. Metals and Neurodegeneration. Ed. Shile Huang ResearchSignpost.

Grants and Awards

Grants Title Sponsor Funding

PeriodAmount Role

Neurobiological dysfunction due to dietary iron/manganese imbalance - Received

UNCGNewFaculty

04/2004-07/2005

$5,000 P.I.

Neurobiological dysfunction due to dietary iron/manganese imbalance - Received

UNCGSummerExcell.

06/2004-08/2004

$4,000 P.I.

Neurotoxicology of dietary iron/manganese imbalance- Received

NIEHSDHHS-R15 ES013791-01

01/2005-12/2007

$209,500

P.I.

Multi-detection Microplate Reader to Enhance Research Competitiveness in Nutrition- Received

USDA 07/2005-07/2006

$18,743 Co-PD

Mechanisms of Manganese Neurotoxicity(Michael Aschner, P.I., Vanderbilt University) - Received

NIEHSDHHS

12/0611/11

N/A Consult.

Mechanisms of Manganese Neurotoxicity: Link between oxidative stress and glutathione depletion- Received

NIEHSDHHS-R15PA-06-042

12/07-11/10

$209,500

P.I.

Mechanisms of Manganese Neurotoxicity-Renewal(Michael Aschner, P.I., Vanderbilt University) - Received

NIEHSDHHS

12/1211/17

N/A Consult.

Nrf2-dependent endogenous antioxidant defense and neuroprotection in a mouse model of Parkinson's Disease (Z. Jia, P.I. Biology Dept.-UNCG)

NIEHSDHHSRO3

9/12-8/14

$139,000

Collab.5% effort

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CV-Keith M. Erikson

Not FundedManganese Neurotoxicity Alters Cellular Regulation of the GABA Transporter- Received

UNCGRegularFacultyGrant

1/12-6/13

$5,000 P.I.

HHS Office of Research Faculty Summer Scholarship Award- Received

UNCGHHS

5/12 $8,000

Role of Ncb5or in mitochondrial function and brain aging-not funded

NINDSDHHSR21

10/12-14 $229,000

Collab.5% effort

Brain iron and H:ferritin Expression in obese mice- not funded

NCTracs 2/13 $2,000 Co-PI

Altered brain iron due to obesity is linked with neurodegeneration(scored but not funded) resubmitted July 2015

NIEHSDHHSRO3

9/14-8/16

$140,000

P.I.

Regulation of iron and its influence on metal-related neurological disorder

NIMHDHHSRO1

4/17-3/22

$405,000

Co-PI (one of three PIs)

Altered brain iron due to obesity is linked with neurodegenerationResubmitted as R15

NIEHSDHHSR15

6/17-5/20

$429,000

P.I.

Systems Genetics Analysis of individual differences in brain iron regulation and its impact on other metals and their neurotoxicity

NIEHSDHHSRO1

9/18-8/23

$405,000

P.I.

Sex and genetic factors involved in the alterations of brain iron biology due to obesity

HHS Res Excell.Research office

5/18-4/19

$5,000

$5,000

P.I.

Honors and Awards APS select journal award, American Physiology Society, 2018 Mead Johnson Award, American Society for Nutrition, 2010 Student nominated Honorary member of University Marshals (2010) International Life Science Institute Future Leader Finalist, 2007 UNCG, Research Excellence Award (Junior Faculty), 2007 UNCG, School of Human Environmental Science Early Career Research Excellence

Award, 2006

Primary Collaborations:

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CV-Keith M. Erikson

Dr. Michael Aschner at Vanderbilt University:

We are currently measuring the manganese levels in C. elegans that have had different metal transporters knocked out. Dr. Aschner has a funded RO1 which employs this worm model and thus I am a consultant on this grant.

Dr. Brad Racette at Washington University in St. Louis Medical School

Dr. Racette is currently collecting specimens from patients with liver disease and we are measuring serum manganese and iron concentrations. Dr. Racette is monitoring 856 welders for neurological signs and metal imbalances. He has enlisted us to measure the serum manganese and iron in these patients.

Dr. Christa Colyer at Wake Forest University

Dr. Colyer has expertise in capillary electrophoresis (CE) and is analyzing the cerebrospinal fluid we are collecting in our experiments for amino acid neurotransmitters (Glutamate, GABA). CE is now regarded as the gold standard in vivo measurement for these neurotransmitters.

Dr. Aaron Bowman at Vanderbilt University:

Since November 2007, we have worked on a collaborative project investigating the mechanism(s) involved in the altered metal metabolism associated with Huntington’s Disease. In particular, we have been focusing on our novel finding of manganese deficiency inherent in animals and cells that express the mutant HD protein.

Dr. Alyssa Hasty at Vanderbilt University:

We are currently investigating iron metabolism in various tissues of obese mice. Dr. Hasty is interested in macrophage biology due to obesity, particularly their role in iron biology. My laboratory has measured iron in several tissues and cells from obese mice across four different studies.

Dr. Jian Han, NC A&T University

Dr. Han is a research scientist who focuses on the role of iron in metabolic disorders such as diabetes. We are collaborating on a project which will look at varying levels of dietary fat and iron on brain iron biology. We are particularly focused on the handling of the iron in brain regions where neurodegenerative diseases are initiated (e.g., midbrain and Parkinson’s disease). I am on the thesis committee of one of her MS students.

Dr. Byron Jones, UTHSc

Since 2014, we have worked on a collaborative project investigating the role of brain iron in metal-induced neurodegenerative diseases using a systems genetics approach. We are submitting a grant June 2017 that proposes to look at the individual differences in iron regulation and the impact on other divalent metals and their toxicities.

Teaching Experience

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Spring 2018 Instructor, Nutrition and Human Metabolism (NTR-531) Instructor, Antioxidants and Bioactive Components of Food (NTR 627)

Fall 2017 Instructor, Introductory Nutrition (NTR-213) Instructor, Seminar in Nutrition (NTR-609)

Spring 2017 Instructor, Nutrition and Human Metabolism (NTR-531) Instructor, Antioxidants and Bioactive Components of Food (NTR 627)

Spring 2016 Instructor, Nutrition and Human Metabolism (NTR-531)

Fall 2015 Instructor, Introductory Nutrition (NTR-213) Instructor, Seminar in Nutrition (NTR-609)

Spring 2015 Instructor, Antioxidants and Bioactive Components of Food (NTR-627)

Fall 2014 Instructor, Introductory Nutrition (NTR-213)

Spring 2014 Instructor, Antioxidants and Bioactive Components of Food (NTR-627)

Fall 2013 Instructor, Introductory Nutrition (NTR-213)

Spring 2013 Instructor, Antioxidants and Bioactive Components of Food (NTR-627)

Fall 2012 Instructor, Introductory Nutrition (NTR-213)

Spring 2012 Instructor, Antioxidants and Bioactive Components of Food (NTR-627)

Fall 2011 Instructor, Introductory Nutrition (NTR-213)

Spring 2011 Instructor, Antioxidants and Bioactive Components of Food (NTR-627)

Fall 2009 Instructor, Antioxidants and Bioactive Components of Food (NTR-627) Instructor, Introductory Nutrition (NTR-213) Instructor, Seminar in Nutrition (NTR-609)

Spring 2009 Instructor, Introductory Nutrition (NTR-213)

Fall 2008 Instructor, Antioxidants and Bioactive Components of Food (NTR-627

Spring 2008 Instructor, Introductory Nutrition (NTR-213) Instructor, Seminar in Nutrition (NTR-609)

Fall 2007 Instructor, Antioxidants and Bioactive Components of Food (NTR-627)

Spring 2007 Instructor, Antioxidants and Bioactive Components of Food (NTR-627) Fall 2006 Instructor, Nutrition: Facts and Fantasies (NTR-213)

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CV-Keith M. Erikson

Spring 2006 Instructor, Antioxidants and Bioactive Components of Food (NTR-627) Instructor, Seminar in Nutrition (NTR-609)

Fall 2005 Instructor, Nutrition: Facts and Fantasies (NTR-213)

Spring 2005 Instructor, Antioxidants and Bioactive Components of Food (NTR-627)

Fall 2004 Instructor, Nutrition: Facts and Fantasies (NTR-213) Instructor, Seminar in Nutrition (NTR-609)

Spring 2004 Instructor, Nutrition: Facts and Fantasies (NTR-213)

Fall 2003 Instructor, Seminar in Nutrition (NTR-609) Co-Instructor, Nutrient Metabolism (NTR-625)

Fall 2000 Instructor, Introduction to Nutrition (NFS-213), Co-instructor, Nutrient Metabolism (NFS-625) Department of Nutrition and Foodservice Systems,

Committee memberships:

University Chair Institutional Animal Care and Use Committee (Jan. 2018-present) Radiation Safety Committee (2017-present) Strategic Planning Committee (2014-2017) Healthy UNCG Advisory committee (2012-2014) GNS ad-hoc recertification subcommittee (2009-2010) Institutional Animal Care and Use Committee (2003-2009) (2017-present) Russ Harter Award committee (Judge Abstracts and then papers submitted by

Undergrad researchers) (2004-2008) Search Committee for Nanotechnology Center Director (2005-2006) Search Committee for Chemistry Dept. (2004) Search Committee for Biology Dept. (Fall 2012)

School HES Advisory Committee on Research (2009-2012) HHS Advisory Committee on Research (2016-present) Search Committee for Kinesiology Dept. (2017-18)

Department Director of Graduate Studies (2009-2016) (Fall 2017) Bench Research Committee (2003-present) NTR 213 Committee (develop and modify the introductory nutrition course) (2003-

present) ASN Notes (2003-2009) Graduate Committee (2004-present) Faculty Search committee (2005, 2006, 2012, 2016)

Graduate Students

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CV-Keith M. Erikson

Joel Anderson PhD graduated May 2009, currently an associate professor in the school of Nursing at UT-Knoxville.

Steven Fordahl MS graduated December 2009-PhD graduated December 2013, currently an assistant professor; Department of Nutrition, UNCG. Previously, post-doctoral fellow in the Physiology/Pharmacology Dept. Wake Forest School of Medicine

Shatha Farah MS graduated August 2011- currently a research technician at Texas Tech University

Justin Plummer MS student graduated Fall 2014; currently scientific laison for a biotech company in Durham, NC

Melissa Totten PhD student since Fall 2016 Derek Matthew Pierce MS student since Fall 2017 I serve on the committee of four doctoral students and one master of science student in

the Department of Nutrition. I serve on the committee of one doctoral student, Kevin Ritsche in the Department of

Kinesiology (2010-2015). I serve on the committee of one doctoral student, Sudipta Chakraborty, in the

Neuroscience Graduate Program at Vanderbilt University (2012-2015). I serve on the committee of one masters student, Aria Byrd, in the biology department

at N.C. A&T state university (2013-2015). I serve on the committee of doctoral student, Lauren Vervaecke in the Dept of

Kinesiology (2015-present).

Professional Activities:

Associate Editor, Nutritional Neurosciences (September 2013-August 2019) (Impact Factor 2016: 3.765)Editorial Board Member of the Journal of Neurotoxicology (March 2011-February 2014; March 2014-December 2017; January 2018-December 2020)Editorial Board Member of the World Journal of Pharmacology (2011-2015)Editorial Board Member of the ISRN Toxicology Journal (2011-2015)Editorial Board Member of the New Journal of Science (Toxicology section) (2013-2017)

Award Jury ASN awards (Mead Johnson) 2018

Reviewer:

Journals:American Journal of Physiology-GI and Liver PhysiologyArchives of Industrial Hygiene & ToxicologyBrain ResearchBiological Trace Element ResearchDiabetes Research and Clinical PracticeEcotoxicology and Environmental SafetyEnvironmental ResearchEnvironmental Toxicology and PharmacologyExperimental NeurologyFood and Chemical ToxicologyFree Radical Biology and MedicineFuture NeurologyInhalation Toxicology

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CV-Keith M. Erikson

InVitro ToxicologyJournal of Applied PhysiologyJournal of Pharmacy and PharmacologyJournal of Toxicology and Environmental HealthJournal of NeurochemistryNeurochemical ResearchNeuropharmacologyNeuroscienceNeuroscience LettersNeuroreportNeurotoxicologyNeurotoxicology and TeratologyNutrition and NeurosciencePediatric ResearchPharmacological ReportsPhysiology and BehaviorToxicology LettersToxicological SciencesToxicology and Applied PharmacologyToxicology and Environmental Health

Grants:

-NIH PPG NHLBI “Immunologic and Neurodevelopmental Consequences of Neonatal Anemia and Thrombocytopenia and their Treatments” (2017) (2018-revised protocol)-NIH ARRA AREA special emphasis panel 08 (2009)-Center for Molecular Toxicology Pilot Study Grant, Vanderbilt University (2007)-Canada Foundation for Innovation Grant (2004)

Professional Memberships

Society of ToxicologyAmerican Society for Nutrition

Invited Presentations:

University of Tennessee Health Sciences, Dept. of Genetics, Genomics and Bioinformatics, February 9, 2018. Neurochemical mechanisms of manganese neurotoxicity.

American College of Sports Medicine, Boston, MA June 2016. The effects of high fat diet on oxidative stress in the hindbrain: a pilot study. L. Vervaecke, A. Goldfarb, K Erikson.

North Carolina A&T State University, Department of Family and Consumer Sciences, November 17, 2015. Manganese its essentiality and toxicity (lecture for FCS 715, Trace Elements and Nutrition).

Experimental Biology, Boston, MA April 2015. Dietary induced obesity disturbs iron homeostasis and alpha synuclein expression in C57/BL6 mouse brains. Aria Byrd, Justin Plummer, K Erikson, J Han.

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CV-Keith M. Erikson

University of Tennessee Health Sciences, Dept. of Genetics, Genomics and Bioinformatics, February 27, 2015. Altered brain iron due to dietary induced obesity: implications for neurodegeneration.

Experimental Biology, Boston, MA April 2013. Isorhamnetin modulates the γ-aminobutyric acid transporter GAT-3 in mesencephalic and cortical astrocytes exposed to neurotoxic manganese (My doctoral student, Steve Fordahl presented these data).

Society of Toxicology, Washington, D.C. March 2011. Waterborne manganese exposure alters stereotypic behaviors and plasma metabolites in developing rats. (My graduate student, Steve Fordahl presented these data).

North Carolina A&T State University, Biology Departmental Colloquium, November 2010. Neurochemical Alterations Associated with Manganese Neurotoxicity.

Experimental Biology, Anaheim, CA April 2010. Effect of manganese exposure and antioxidant therapy on oxidative stress in the rat brain. (My graduate student, Steve Fordahl presented these data).

Experimental Biology, New Orleans, LA April 2009. Manganese exposure and iron deficiency result in home cage behavior alterations in the developing rat (My graduate student, Joel Anderson presented this poster).

Experimental Biology, New Orleans, LA April 2009. The effect of manganese exposure on endogenous markers of oxidative stress in astrocytes (My graduate student, Steve Fordahl presented this poster).

North Carolina A&T State University, Nutrition Departmental Colloquium, October 2008. Nutritional Implications of Manganese Neurotoxicity.

Society of Toxicology, Seattle, WA March 2008. Manganese exposure alters GABA and norepinephrine transporter protein expression in the developing rat brain (My graduate Student presented this poster).

Hamner Institutes of Health, Durham, NC July 2007. Neurobiological and nutritional implications of manganese toxicity.

Experimental Biology, Washington, DC, April 2007. Iron deficiency and manganese toxicity are associated with differential effects on neurotransmitter uptake. (My graduate student presented this poster).

Society of Toxicology, San Diego, March 2006. Determination of Brain Manganese Accumulation using Magnetic Resonance Imaging and Atomic Absorption Spectroscopy.

Society of Toxicology, San Diego, March 2006. Effects of Manganese Chloride on 3 isoforms of Divalent Metal Transporter Knockouts in C. Elegans.

Society of Toxicology, San Diego, March 2006. Effect of Dopamine Transporter Blockade on Dietary Iron/Manganese Interactions in the Developing Brain. (My graduate Student Joel Anderson presented this poster)

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CV-Keith M. Erikson

Society of Toxicology, San Diego, March 2006. Dietary iron modulates manganese neurotoxicity. Coauthored with Dr. Michael Aschner and presented in the symposium “Manganese Neurotoxicity: From Worms to Man”

International Neurotoxicology Conference, Research Triangle Park, NC, September 2005. Use of MRI to determine the distribution of brain Mn in male Sprague-dawley rats.

Experimental Biology, San Diego, CA April 2005. Brain manganese accumulation due to toxicity is mediated by the dopamine transporter.

Society of Toxicology, New Orleans, LA March 2005. Determination of depleted uranium (DU) in rats following 6-month exposure to surgically implanted DU pellets.

Seminar Speaker, Biology Dept., UNCG, Feb. 2004. Neurochemical and Neurotoxicological implications of iron deficiency.

Seminar Speaker, Dept. Natural Sciences, Messiah College, Grantham, PA. April, 2003. Brain manganese accumulation due to iron deficiency causes neurochemical alterations.

Society of Toxicology, Salt Lake City, UT, March 2003. Increased manganese uptake in iron deprived and iron overloaded primary astrocyte cultures is due to increased divalent metal transporter. K.M. Erikson, A.W. Dobson, M. Aschner. Seminar Speaker, Dept. Physiology/Pharmacology, Wake Forest University School of Medicine, February 2003. Neurochemical alterations due to Iron and Managanese interactions in the brain. Society for Neuroscience, Orlando, FL, November, 2002. Irreversible effects of early iron-deficiency on brain dopamine systems in the rat. B. C. Jones, K. M. Erikson, J. L. Beard.

Society of Toxicology, Nashville, TN, March 2002. Iron deficiency causes region-specific manganese accumulation in developing rat brains. K. M. Erikson, M. Aschner.

Experimental Biology, Orlando, FL, April 2001. Iron repletion does not normalize brain dopamine metabolism. J. Beard, K. Erikson, B. Jones, Q. Zhang.

Society for Neuroscience, New Orleans, LA November, 2000. Early iron deficiency alters neurochemical and behavioral sensitivity to cocaine in rats. K.M. Erikson, B.C. Jonesand J.L. Beard.

Experimental Biology, San Diego, CA, April 2000. Iron deficiency alters dopamine metabolism in rat striatum by decreasing dopamine transporter density. K.M. Erikson, B.C. Jones and J.L. Beard.

Colloquium speaker, Graduate Program in Nutrition, The Pennsylvania State University, November, 1999. Entitled: Iron Deficiency alters rat brain dopamine metabolism.

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CV-Keith M. Erikson

Experimental Biology, Washington DC, April 1999. Regional Differences in Rat Brain Dopamine Receptor Functioning Due to Iron Deficiency. Q. Zhang, K.M. Erikson and J.L. Beard.

Experimental Biology, Washington DC, April 1999. Dopamine Transporter Functioning is Altered in Rat Striatum Due to Iron Deficiency. K.M. Erikson, Q. Zhang and J.L. Beard.

Experimental Biology, San Francisco, CA April 1998. Tissue Transferrin Receptor, Transferrin and Ferritin ELISA Assays to Assess Levels in Iron Deficient Anemic Rats. N.Q. Li, D.J. Pinero, K. Erikson, J.R. Connor and J.L. Beard.

Experimental Biology, San Francisco, CA April 1998. Regional Brain Iron, Transferrin Receptor and Transferrin Levels in Iron Deficient Anemic Rats. J.L. Beard, N.Q. Li, D.J. Pinero, K. Erikson and J.R. Connor.

Experimental Biology, New Orleans, LA April, 1997. Regional Brain Iron, Ferritin and Transferrin Levels in Iron Deficient Anemic Piglets. K.M. Erikson and J.L. Beard

Experimental Biology, Washington, DC April, 1996. Brain Iron, Ferritin, and Transferrin Levels in Iron Repleted Rats. K.M. Erikson and J.L. Beard.

Experimental Biology, Washington, DC April, 1996. Dopamine Reuptake in Caudate Putamen in Anemia Assessed by in vivo Microdialysis. C.L. Nelson, K.M. Erikson and J.L. Beard.

The American Dietetic Association, 77th Annual Meeting, Orlando, FL October, 1994. Relationship of Upper Arm Anthropometry to Body Composition in Female Athletes. K.M. Erikson, K. Witt, and D.L. Miller.

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