CURRICULUM VITAE

NAME: David S. Wilkes M.D. WORK ADDRESS: Indiana University School of Medicine 340 West 10th Street

Fairbanks Hall, Suite 6200 Indianapolis, IN 46202 PHONE: (317) 278-7020 FAX: (317) 274-8439 EMAIL: dwilkes@iu.edu AREAS OF EXCELLENCE: Research, Administration, Teaching EDUCATION: Undergraduate: 1974-1978 Villanova University, Villanova, Pennsylvania,

B.S., Biology Graduate: 1978-1982 Temple University School of Medicine,

Philadelphia, Pennsylvania, M.D. Post Doctoral: 1982-1983 Temple University Hospital, Philadelphia, Pennsylvania, Intern, Department of Medicine 1983-1985 Temple University Hospital, Philadelphia,

Pennsylvania, Resident, Department of Medicine

1989-1992 University of Texas Southwestern Medical Center, Dallas, Texas, Pulmonary and Critical Care Fellow, Department of Medicine

ACADEMIC APPOINTMENTS: Primary 2009-present Executive Associate Dean for Research Affairs, Indiana University School

of Medicine

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2009-present August M. Watanabe Professor of Medical Research, Indiana University School of Medicine

2010-present Assistant Vice President for Research, Indiana University 2004 – 2009 Dr. Calvin H. English Professor of Medicine, Division of Pulmonary and

Critical Care Medicine, Indiana University School of Medicine 2004 – present Director, Center for Immunobiology, Indiana University School of

Medicine 1997 - 2004 Associate Professor, Department of Medicine, Pulmonary/Critical Care

Division, Indiana University Medical Center 1992 - 1997 Assistant Professor, Department of Medicine, Pulmonary/Critical Care

Division, Indiana University School of Medicine 1986 - 1989 Clinical Instructor, Department of Medicine, University of Texas Southwestern Medical Center, Parkland Memorial Hospital, Dallas, Texas

Secondary 2006- present Professor of Biochemistry and Molecular Biology, Indiana University

School of Medicine. 2004- present Professor of Microbiology and Immunology, Indiana University School of

Medicine 1997- 2004 Associate Professor, Department of Microbiology and Immunology,

Indiana University School of Medicine 1997 – Present Faculty of the Graduate School, Indiana University Purdue University at

Indianapolis HOSPITAL AND OTHER APPOINTMENTS: 2010-present Director, Strategic Research Initiative Indiana University School of

Medicine and Indiana University Health 2010-present Chair, IU Health Thoracic Transplant Oversight Board 2009-present Director, Physician Scientist Initiative, Indiana University School of

Medicine – ($60M grant from the Lilly Foundation) 2002 – 2004 Director, Clinic for Sarcoidosis and Immunologic Lung Diseases, Indiana

University Medical Center 2000 – 2003 Vice Chairman for Research, Department of Internal Medicine, Indiana

University School of Medicine 1997 - 2000 Chairman, Ethics Committee, Vencor Hospital, Indianapolis 1996 - 1999 Medical Director of Intensive Care Unit, Vencor Hospital, Indianapolis 1996 - 1998 President of Medical Staff, Vencor Hospital, Indianapolis 1993 - 1995 Vice President of Medical Staff, Vencor Hospital, Indianapolis 1992 – Present Staff Physician, Department of Medicine, Pulmonary Division, Indiana

University Medical Center and Wishard Memorial Hospital, Indianapolis, IN

1985 - 1988 Major, United States Air Force, Medical Corp.

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1985 - 1988 Staff Internist and Intensive Care Unit Director, R.L. Thompson Regional Hospital, Carswell Air Force Base, Texas

SPECIALTY BOARD STATUS: 1992 Diplomate, American Board of Internal Medicine, Subspecialty - Pulmonary

Disease – Recertified 2003 1991 Diplomate, American Board of Internal Medicine, Subspecialty - Critical Care

Medicine – Recertified 2002 1985 Diplomate, American Board of Internal Medicine 1983 Diplomate, National Board of Medical Examiners

LICENSURE AND CERTIFICATIONS: Physician, State of Indiana 1992 - present

PROFESSIONAL SOCIETIES: American College of Physicians

Member since 1989, Fellow 2001 American Thoracic Society Member since 1989 Board of Directors 2005 – 2007 Chair, Allergy, Immunology, Inflammation Assembly (AII) 2005 – 2007 ATS Executive Director Search Committee – 2006 - 2007 Minority Trainee Travel Award Committee – 2002 – 2009

Planning Committee, AII Assembly 1999 – 2005, 2007-2009 Program Committee, Allergy, Immunology, Inflammation Assembly

1997 – 2000, 2003-04, 2007 - 2009 Chair, Planning Committee, Allergy, Immunology, Inflammation Assembly, 2000-02 Nominating Committee 1998 - 2000 Pulmonary and Critical Care Training Committee 1999-2000 Minority Task Force Committee 1996-1997 American Association for the Advancement of Science

Member since 1992 American Federation of Medical Research Member 1982 - 2006 Midwest Regional Counselor, November 1995 – 1999 American Lung Association of Indiana Member since 1992 American College of Chest Physicians Fellow since 1999

Publications Committee 1999 – 2002 American Association of Immunologists

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Member since 2000 International Society of Heart and Lung Transplantation Member since 2002 Abstract Review for Annual Meeting – 2004 – present Pulmonary Disease Council – 2010- present Grants and Award Committee – 2012- present American Society of Transplantation Member since 2004 AST – NIH Committee, 2005 – present Research Grant Reviewer - 2008 ENTREPRENEURIAL ACTIVITIES AND PATENTS 2006-Present Co-Founder and Chief Scientific Officer; ImmuneWorks Inc.

www.immuneworks.com 2010-2012 Scientific Consultant, Moerae Matrix, LLC. Patents: Method to Identify Patients at Risk for Lung Transplant Rejection. US Patent Number 8039225 Issued April 7, 2011. Molecules for the Treatment of Lung Disease Involving an Immune Reaction to Connective Tissue Found in the Lung. US Patent Number 7759075. Issued July 20, 2010 Oral Tolerance Induction by Collagen to Prevent Allograft Rejection.US Patent Number 7348005. Issued April 25, 2008. Compositions and Methods for the Treatment of Asthma. US Patent Number 8568730. Issued October 29, 2103 Compounds and Methods for Inhibiting MMP2 and MMP9. Patent Pending. US Number US2010/023585. NATIONAL INSTITUTE OF HEALTH/STUDY SECTIONS/ADVISORY BOARDS 2012-2016 Board of Scientific Counselors, NIH, National Heart, Lung, and Blood Institute 2012-present External Advisory Committee, NIH funded tPPG entitled: Elafinas a Therapy for

Lung Disease. Stanford University School of Medicine 2012- present International Society Heart and Lung Transplantation Grant Review Committee 2012 AITC Study Section Reviewer for NIAID, NIH 2012 Study Section Reviewer for NHLBI Phase II Clinical Trials of Novel Therapies

for Lung Diseases, NIH 2011 Advisory Board, Nina Ireland Lung Disease Center, Univ. Calif. San Francisco

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2009 Reviewer: NIH Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network

2009 Roche Organ Transplant Research Fund Clinical Transplantation Research Grants reviewer

2007-2011 Parker B. Frances Foundation Scientific Advisory Committee 2007-2010 External Advisory Committee, NIH SCCOR Program in Chronic Lung Disease,

Duke University School of Medicine. 2005–2010 Idiopathic Pulmonary Fibrosis Clinical Network – Protocol Review Committee, National Heart, Lung and Blood Institutes. 2006-2010 National Advisory Council, National Institutes of Allergy and Infectious

Diseases, National Institutes of Health 2006 Strategic Planning Committee, Division of Lung Diseases, National Heart Lung

and Blood Institutes. Injury/Inflammation; Repair/Remodeling; Replacement/Regeneration.

2005 Chair, Special Emphasis Panel, National Institutes of Health, National Institute of Allergy and Infectious Diseases. “ Non-Human Primate Heart/Lung Transplantation Tolerance”.

2004 California tobacco-related disease research program pulmonary disease study section.

2004 Program Project Review Special Emphasis Panel for the National Institute of Allergy and Infectious Diseases.

2004 Co-Chair, Lung Transplant Workshop, Lung Division, National Heart, Lung, and Blood Institutes.

2000-2004 Study Section member - Lung Biology Pathology/Lung Cellular, Molecular, and Immunobiology – Heart, Lung, and Blood Institutes.

2003 Specialized Centers of Clinically Oriented Research (SCCOR) Evaluation Meeting-NIH.

Special Emphasis Panel: Innovative Grants on Immune Tolerance. 1996–2001 Special Emphasis Panel Consultant for K and T series awards

HONORS: 2013-present National Director, Harold Amos Medical Faculty Development Program, Robert

Wood Johnson Foundation 2013 Honorary Doctor of Science, Wake Forest University 2103 Commencement Speaker, Wake Forest University School of Medicine 2011 Who’s Who in the Life Sciences in Indiana, Indianapolis Business Journal 2010-2012 Pulmonary Disease Subspecialty Board – American Board of Internal Medicine 2009-present Association of American Physicians 2009 Pedigo Lecturer, University of Louisville School of Medicine, Department of

Medicine Grand Rounds 2009 The Renzetti Distinguished Lecturer, University of Utah School of Medicine,

Department of Medicine Ground Rounds 2009 The Edward S. Cooper, M.D. Distinguished Lectureship, University of

Pennsylvania School of Medicine. Department of Medicine Ground Rounds 2008 The Latner Visiting Lecturer, Department of Surgery, Univ. Toronto School of

Medicine

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2008 Award of Appreciation – Central Indiana Sarcoidosis Support Group 2008 Bowman Society Lecturer, Univ. Chicago School of Medicine 2008 “Outstanding Faculty”, Prestigious External Award Recognition - Indiana

University Purdue University 2007 Diversity Award, Association of Professors of Medicine 2007 Fifth Annual Johns Hopkins Department of Medicine Diversity Council Visiting

Professorship. 2006 Dudley F. Richardson, M.D. Lectureship, University of Virginia School of

Medicine. 2005-2007 Board of Directors, American Thoracic Society 2002 Planning Committee Chair Award. American Thoracic Society, Assembly on

Allergy, Inflammation, and Immunology 2002 Dr. Joseph T. Taylor Award for Distinguished Contributions to Indiana University

Purdue University at Indianapolis. 2001 Who’s Who of the American Thoracic Society 2000 Alvin S. Bynum Mentoring Award, Indiana University Purdue University at

Indianapolis 1997 Fundraising/Marketing Development Award - American Lung Association of

Indiana 1996 Distinguished Award - Center for Leadership Development, Inc. Indianapolis, IN 1993 Most Outstanding Mentor Award: NIH Summer Student Research Program -

Indiana University School of Medicine 1992-1996 Harold Amos Medical Faculty Development Program Fellow - Robert Wood

Johnson Foundation 1991 Fellowship, Outstanding Research Award, Annual Meeting of Texas Thoracic

Society 1987-1988 Outstanding Physician Award, United States Air Force, R. L. Thompson Regional

Hospital, Carswell AFB, Texas 1985-1988 Commendation Medal for Service, United States Air Force 1985 Residency, Chief Medical Resident (selected), Temple University, Philadelphia,

PA (unable to serve as chief due to call to active duty in USAF) 1984-1985 Residency, Louis Tretin Memorial Award (Most Outstanding Third Year Resident

Internal Medicine), Temple University, Philadelphia, PA 1983-1984 Residency, I. W. Ginsburg, M.D. Award (Most Outstanding Second

Year Resident Internal Medicine), Temple University, Philadelphia, PA EDITORIAL BOARDS 2011-present American Journal of Respiratory and Critical Care Medicine – Editorial

Board 2010-present Science Translational Medicine – Board of Reviewing Editors 2008-2012 Journal of Clinical Investigation – Board of Consulting Editors 2008-present American J. Respiratory Cell and Molecular Biology-Associate Editor 2007-2011 American Journal of Transplantation – Associate Editor

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2007 – 2008 American J. Respiratory Cell and Molecular Biology-Editorial Board 2003 - 2005 American Journal of Physiology: Lung Cellular and Molecular Physiology JOURNAL REVIEWER: Science Translational Medicine Proceedings of the National Academy of the Sciences Journal of Clinical Investigation Journal of Immunology American Journal of Respiratory Cell & Molecular Biology American Journal of Respiratory and Critical Care Medicine Journal of Heart and Lung Transplantation Clinical and Experimental Immunology American Journal of Physiology American Journal of Kidney Diseases Chest Physiological Reviews Molecular Therapy Transplantation American Journal of Transplantation Human Immunology Gene Therapy Circulation Research PlosOne

INVITED PRESENTATIONS: 2013 -“Role of Complement Activation in BOS Post Lung Transplantation”. Program

Faculty and Speaker. Cardiothoracic Transplant Conference, Vail, CO -“Role of Autoimmunity in the Pathogenesis of Idiopathic Pulmonary Fibrosis”.

Banbury Conference, Cold Spring Harbor, NY. -“Autoimmunity to Type V Collagen: An Emerging Paradigm in Lung Disease”.

Grand Rounds, Department of Medicine Research Day, University of Wisconsin School of Medicine, Madison, WI

-“Autoimmunity to Type V Collagen: An Emerging Paradigm in Lung Disease”. Harold Amos Medical Faculty Development Program, Robert Wood Johnson Foundation Annual Meeting, Atlanta, GA.

2012 -Emerging Trends in BOS: Autoimmunity. International Society of Heart and Lung Transplantation. Prague, Czechoslovakia

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- Department of Medicine, Northwestern University School of Medicine. “Careers in Academic Medicine: One Man’s Journey”.

-Department of Medicine Grand Rounds, Northwestern University School of Medicine. “Lung Transplantation: Are we there yet?”.

-School of Science, Indiana University Purdue University at Indianapolis. “Art and Science of Lung Transplantation”.

-Biogen Corporation: “Role of Autoimmunity in Lung Transplant Rejection” 2011 -Department of Medicine Grand Rounds, Temple University School of Medicine,

Philadelphia, PA. “The Art and Science of Lung Transplantation”. -Featured Speaker: University of Colorado, Vail Cardiothoracic Transplant Conference, Vail, CO. “Update on Autoimmunity in Lung Transplantation”, and “Role of IL-17 in Obliterative Bronchiolitis”.

-Plenary Speaker: International Society of Heart and Lung Transplantation: “The Future of Immune Modulation in the Clinical Setting”.

- Invited presentation. “The Role of Autoimmunity to Type V Collagen in the Pathogenesis of Lung Allograft Rejection” NATCO National meeting.

-Invited Presentation. “Role of complement activation in the pathogenesis of obliterative bronchiolitis post lung transplantation”. Alexion Pharmaceuticicals, Hartford, CT.

-Invited presenter: Great Lakes Transplant Immunology Forum, Pittsburg, PA. “Potential Role of Complement Activation in Obliterative Bronchiolitis”.

2010 -Visiting Professor, Medical University of South Carolina Department of

Medicine Grand Rounds. “The Art and Science of Lung Transplantation”. -Distinguished Seminar Speaker, School of Biomedical Engineering, Purdue

University. “The Role of Type V Collagen and IL-17 in the Pathogenesis of Lung Transplant Rejection”.

-Visiting Professor, Northwestern University School of Medicine, Division of Allergy and Immunology. “The Role of Autoimmunity in the Pathogenesis of Lung Transplant Rejection”.

-Invited Presentation: “The Role of Autoimmunity in the Pathogenesis of Lung Transplant Rejection”. American College of Chest Physicians, International Meeting, Vancouver, Canada.

-Expert Commentator and Co-chair: B cells: Do alloantibodies still matter? American Society for Transplantation Scientific Exchange, Orlando, FL.

2009 -Visiting Professor, Pulmonary Division, Univ. of Michigan School of Medicine.

“The Role of Autoimmunity of Type V Collagen in the Pathogenesis of Lung Allograft Rejection”. -Visiting Professor, Tulane University School of Medicine, Department of Medicine Grand Rounds. “The Art and Science of Lung Transplantation”.

-Visiting Professor, Lovelace Respiratory Research Institute, “Role of Type V Collagen in the Pathogenesis of Lung Transplant Rejection”.

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-“Role of Autoimmunity to Type V Collagen in Lung Transplant Rejection”. Methodist Hospital, Indianapolis, Indiana.

-The Renzetti Distinguished Lecturer, University of Utah School of Medicine, Department of Medicine Ground Rounds. “The Art and Science of Lung Transplantation”.

-The Edward S. Cooper, M.D. Distinguished Lectureship, University of Pennsylvania School of Medicine. Department of Medicine Ground Rounds. “The Art and Science of Lung Transplantation”.

-Visiting Scholar, Eli Lilly Corp. The Role of Type V Collagen in the Pathogenesis of Lung Transplant Rejection”.

2008 -Visiting Professor, Duke University School of Medicine, Pulmonary Division

Research Conference. “The Autoimmune Basis of Chronic Lung Allograft Rejection”.

-“Autoimmunity to Type V Collagen in Lung Transplant Rejection”. International Society of Heart and Lung Transplantation, Boston, MA.

-“What is the Role of Autoimmunity in the Pathogenesis of OB?, “Pneumonia in Solid Organ Transplant Patients”. American Thoracic Society International Meeting, Toronto, Canada

-Visiting Professor, Stanford University School of Medicine, Immunology Program. “The Autoimmune Basis of Chronic Lung Allograft Rejection”.

-Visiting Professor, University of Alabama School of Medicine. Grand Rounds, Department of Medicine: “The Art and Science of Lung Transplantation”; Division of Pulmonary and Critical Care Medicine Research Conference: “The Role of Autoimmunity in the Pathogenesis of Lung Transplant Rejection”; and Fellows Conference: “A Career in Science and Medicine – One Man’s Journey”

2007 -Visiting Professor, Univ. Wisconsin, Div. of Transplantation Research

Conference. “The Autoimmune Basis of Chronic Lung Allograft Rejection”. -Visiting Professor, Ohio State University School of Medicine. Transplantation

Research Conference. “The Autoimmune Basis of Chronic Lung Allograft Rejection”. -Featured Speaker, Lung Transplantation Post-Graduate Course: “Immunology of Lung Transplantation: Self, Non-self, and Tolerance”. American Thoracic Society International Conference, San Francisco, CA. -Faculty – 6th Vail Cardiothoracic Transplantation Conference, Vail, Colorado. “The Role of Autoimmunity in the Pathogenesis of Chronic Lung Allograft Rejection”, “The Role of Metalloproteinases in the Pathogenesis of Rejection”.

-Visiting Professor, UCLA School of Medicine, Division of Pulmonary and Critical Care Medicine. “The Role of Autoimmunity in the Pathogenesis of Lung Allograft Rejection”.

-Invited Lecturer. Japanese Society of Clinical Cytology, Chiba, Japan. “The Art and Science of Lung Transplantation”.

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2006 -Visiting Professor, University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, “The Autoimmune Basis for Chronic Lung Allograft Rejection”.

-“State of the Art Lecture: Pathogenesis of Chronic Lung Allograft Rejection”. World Transplant Congress, Boston, MA.

-“A Career in Academic Medicine – One Man’s Journey”. School of Science, Purdue University, IN. -“Autoimmunity in Lung Allograft Rejection”. FASEB Transplantation Summer Conference, Snowmass, CO.

-Visiting Professor, Univ. Vermont, Immunobiology Program “Is Chronic Lung Allograft Rejection an Autoimmune Disease”? 2005 -Visiting Professor, Univ. Wisconsin at Madison

Department of Surgery: “A Paradigm Shift – Autoimmunity to Type V Collagen Mediates Chronic Lung Transplant Rejection” Department of Pathology and Laboratory Medicine: “Immunopathogenesis of Type V Collagen Induced Tolerance and Immunity to Lung Transplants”.

-Visiting Professor, Mayo Clinics, Rochester, MN Sigma Xi Visiting Scholar Lecture: “A Life in Academia – One man’s Journey” Pulmonary Division Lecture: “Lung Transplant Rejection: A Disease of Autoimmunity”

-T35/SROP Student Conference – “How to Choose a Mentor” Graduate School the Indiana University School of Medicine -American Thoracic Society, International Meeting:

“A Life in Academia – One man’s Journey” “Models of Tolerance Induction in Lung Transplantation” “Grant Budgeting Basics”

-Featured Speaker: Federation of Clinical Immunology Societies Annual Meeting: “Autoimmunity in the Pathogenesis of Lung Allograft Rejection”. -Featured Speaker: International Society for Heart and Lung Transplantation

annual meeting. OB/BOS State of the Art: “Innate Immunity, Humoral Immunity, De novo Anti-HLA Antibodies”

-Visiting Scholar, Center for Drug Evaluation and Research, Federal Drug Administration. “Autoimmunity and Alloimmunity in Lung Transplant Rejection”.

-“Visiting Pulmonary Scholar”, Centers for Health Research (Duke University, National Institute of Environmental Health Sciences, North Carolina State University Veterinary School, U.S. Environmental Protection Agency, and University of North Carolina): “Allo- and Autoimmune-related Mechanisms of Transplant Rejection”.

2004 -Featured Speaker: “Art and Science of Lung Transplantation”. Presented at the Dean’s Sponsored Grand Rounds”, Indiana University School of Medicine. -Featured Speaker: “Pneumonia in the Elderly”. National Medical Association annual meeting. -Featured Speaker: “Indoleamine 2,3 dioxygenase in Transplantation Tolerance”.

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American Thoracic Society International Meeting. -Featured Speaker: “Autoreactivity to Collagen V Influences Lung Transplant

Rejection”. American Transplant Congress Annual Meeting. -Visiting Professor – Stanford University School of Medicine – Division of

Pulmonary and Critical Medicine. “The Role of Autoimmunity to Type V Collagen in the Pathogenesis of Lung Allograft Rejection”.

-Visiting Professor – University of Pennsylvania School of Medicine, Division of Pulmonary and Critical Care Medicine. “The Impossible Dream: Induction of Immune Tolerance to Lung Allografts”.

-Visiting Professor – University of Florida at Gainesville. Division of Pulmonary and Critical Care Medicine. “The Impossible Dream: Induction of Immune Tolerance to Lung Allografts”.

-Visiting Professor – University of New Mexico School of Medicine at Albuquerque, Department of Pathology Grand Rounds – “Models of Oral Tolerance Induction for the Prevention of Lung Allograft Rejection”.

-Visiting Professor – Emory University School of Medicine, Department of Medicine Grand Rounds – “The Art and Science of Lung Transplantation”; Transplantation Immunology Research Conference - “Friend or Foe – Immune Responses to Type V Collagen in the Pathogenesis of Lung Allograft Rejection”.

2003 -Visiting Professor – University of Pittsburgh School of Medicine, Pulmonary

Division Research Conference. “Friend or Foe – Immune Responses to Type V Collagen in the Pathogenesis of Lung Allograft Rejection”.

-Featured Speaker: Meet the Professor presentation at the American Thoracic Society International Meeting. “Lung Transplantation – from the Bedside to the Bench”.

-Featured Speaker: American Transplant Congress: “Correlation of Bronchiolitis Obliterans with Autoimmunity to Collagen V after Lung Transplantation”.

-Visiting Professor – Northwestern University School of Medicine, Pulmonary Division Research Conference. “Lung Allograft Rejection: A Disease of Autoimmunity and Alloimmunity”.

-Visiting Professor- University of Tennessee at Memphis, Rheumatology Grand Rounds: Autoimmunity and Alloimmunity in the Pathogenesis of Lung Allograft Rejection.

2002 -Featured Speaker: The Impossible Dream: Induction of Immune Tolerance to

Lung Allografts. Lung Transplantation Immunology Symposium. International Meeting American Thoracic Society, Atlanta, GA.

-Invited Speaker: “Novel Approaches to Induce Immune Tolerance to Lung Allografts”. 2nd Regensberg Immunology Meeting. University of Regensberg, Regensberg, Germany.

2001 -Japanese Society of Bronchology. Keynote Speaker: “Role of Bronchoscopy in

Lung Allograft Recipients”. Chiba, Japan. -Visiting Professor – Chiba University School of Medicine, Japan. “Induction of

Immunological Tolerance to Lung Allografts.”

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2000 -Visiting Professor – University of Iowa School of Medicine: “The Impossible

Dream – Induction of Tolerance to Lung Allografts” -Visiting Professor – Ohio State University School of Medicine: “Utilization of

Type V Collagen for Tolerance Induction to Lung Allografts” -Visiting Professor – University of Wisconsin School of Medicine at Madison:

“Induction of Immunological Tolerance to Lung Allografts” -Visiting Professor – Fibrogen Corporation, San Francisco, CA. “Oral Tolerance

Induction by Type V Collagen Prevents Acute Lung Allograft Rejection” -Visiting Professor- University of Michigan School of Medicine: Induction of

Immune Tolerance to Lung Allografts” 1999 -Visiting Professor - University of Wisconsin: "Role of Donor Lung Macrophages

in Lung Allograft Rejection"; "Evidence for an Autoimmune Response in Lung Allograft Rejection”

-Visiting Professor - Emory University School of Medicine: "Immune Response During Lung Allograft Rejection"

-Chairman/Speaker - Symposium "Pathogenesis of Lung Allograft Rejection". American Thoracic Society National Meeting

-Co-chairman - Symposium "Immune Modulators and Mediators". American Thoracic Society National Meeting

1998 -Visiting Professor/Invited speaker - Johns Hopkins University School of

Medicine. "Role of Passenger Leukocytes In Lung Allograft Rejection" -Visiting Professor/Invited speaker - Washington University School of Medicine.

"Role of Accessory Cells on Lung Allograft Rejection" -Faculty, Post-Graduate Course. “Opportunistic Infections in Transplantation” American Thoracic Society National Meeting -Invited Speaker - “Role of Passenger Leukocytes in Lung Allograft Rejection”.

Department of Microbiology/Immunology, Indiana University School of Medicine

1997 -Invited Speaker - “Potential Role of Humoral Immunity in Lung Allograft

Rejection”. Robert Wood Johnson Foundation - Minority Medical Faculty Development Program

-Faculty - Post Graduate Course. American College of Chest Physicians National Meeting: Role of Bronchoscopy in Lung Transplant Recipients -Invited Speaker - Pathogenesis of Lung Allograft Rejection, First Alan K. Pierce

Day, University of Texas Southwestern Medical Center 1996 -State of the Art Lecture: “Pathogenesis of Lung Allograft Rejection”, American

Federation for Medical Research, Midwestern Regional Meeting. -Invited Speaker - “The Potential Role of Humoral Immunity in Lung Allograft

Rejection”. American Lung Association/American Thoracic Society International Conference, Lung Transplantation Symposium.

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-Invited Lecturer - Role of Accessory Cells in Lung Allograft Rejection. Department of Immunology and Molecular Biology, Indiana University School of Medicine

FELLOWSHIPS AND AWARDS: ACTIVE AWARDS 9/1/13-8/30/14 Complement inhibition in TBI-induced lung injury in lung

transplantation. Alexion Pharmaceuticals. PI. D.S. Wilkes. $118,052

5/15/12-4/30/16 National Institutes of Health RO1 HL114468. Foxp3+ Treg

Cells and Primary Graft Dysfunction in Clinical Lung Tx Patients. Wayne Hancock, PhD, PI. D.S. Wilkes, Collaborator (5% effort). $78,000 costs to D.S. Wilkes.

8/1/11-7/30/16 National Institutes of Health RO1 HL109288. Role of IL-

17 in the Induction of Epithelial to Mesenchymal Transition. Ragini Vittal, PI. D.S. Wilkes Co-investigator (5% effort). $377,000/year total costs.

7/15/11-7-14/16 National Institutes of Health RO1 HL109310-01. IL-17 and

Lung Transplant Obliterative Bronchiolitis. Rebecca Shilling , PI. D.S. Wilkes Co-investigator (5% effort). $387,000/year total costs.

8/15/10-9/15/15 National Institutes of Health P01 AI084853-“TH17

Autoimmunity to Type V Collagen in Heart and Lung Transplants”. David S. Wilkes, Program Leader and leader Project 3. $5,710,383 total direct costs.

05/14/10-4/13/14 National Institutes of Health Multiple PI RO1 HL096845

“Role of anti-Col (V) immunity in primary graft dysfunction”. David S. Wilkes, Principal Investigator. Jason Christie, Principal Investigator. $575,295/year total costs.

05/01/09-04/30/14 National Institutes of Health T32 HL091816. IU Training

Program in Molecular Physiology and Clinical Mechanisms of Lung Disease. David S. Wilkes, PI. $975,809 direct costs.

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05/01/03 – 08/30/14 National Institutes of Health – 2R25 GM067592-01 Bridges To The Doctorate - Initiative for Minority Students: Bridges to the Doctorate. David S. Wilkes, Co-P.I.

PENDING AWARDS None. PAST AWARDS 09/1/09-08/30/12 National Institutes of Health 2 P01 AI056097-06A1-

“Poxvirus Modulation of Immune Responses”. Principal Investigator: Janice Blum. D.S. Wilkes – Leader of Project 3: “Role of Lung Dendritic Cells in Pulmonary Vaccinia Virus Infection”. Total direct costs: $2,040,000

4/1/11-3/30/13 National Institutes of Health P50. Novel Cellular Immune

Profiles to Predict Lung Disease Outcomes. Scott Palmer, Duke University, Program Director. D.S. Wilkes Collaborator (5% effort). $42,855 costs to DS Wilkes.

05/01/01-07/31/12 National Institute of Health - 2RO1HL/AI67177 - “Oral

Tolerance Induced by Type V Collagen Prevents Lung allograft Rejection”. David S. Wilkes, Principal Investigator ($1,250,000 direct costs).

06/01/10-05/30/11 ImmuneWorks – Immunity Type V Collagen in Lung

Disease. David S. Wilkes, Co-PI , (100,000 annual direct costs).

07/01/08-05/01/09 National Institutes of Health-NCRR-U54 RR025215 -01

Indiana Clinical and Translational Sciences Institute-CTSA. Program Development Team Leader. David S. Wilkes, Co-Investigator. 10% effort.

05/01/08-04/30/10 ImmuneWorks – Immunity Type V Collagen in Lung

Disease. David S. Wilkes, Co-PI , (250,000 annual direct costs).

07/01/07-09/30/09 Quark Biotech Inc. The Role of RTP801 in Ischemia Perfusion Lung Injury. David S. Wilkes, Principal Investigator. Irina Petrache, Co-investigator. Quark Biotech Inc. $250,000.

12/01/06 – 11/31/11 National Institutes of Health – RO1AI59384 - "Human

Immune Response to H. ducreyi Infection". Stanley

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Spinola, Principal Investigator. David S. Wilkes, Collaborator (5% effort). ($1,250,000 direct costs).

09/10/06 – 07/11/09 National Institutes of Health, 3 R01 HL081350-02S

supplement to “MMPs in Alloimmune and Autoimmune Lung Disease” to support Jeremy Lott, graduate student. David S. Wilkes, Principal Investigator. $117,000 total costs.

07/12/05 – 07/11/09 National Institutes of Health, 1RO1 HL081350 “MMPs in

Alloimmune and Autoimmune Lung Disease”. David S. Wilkes, Principal Investigator $1,000,000 direct costs).

06/01/05 – 05/30/10 National Institutes of Health, KO8 HL080701. Lung

Alloimmunity after Bone Marrow Transplant. Co-Sponsor (P.I. Karen Wood, M.D.).

05/01/05 - 04/30/10 National Institute of Health 3T35M - HL07802 - "Short

Term Training for Minority Students in Biomedical Research". David S. Wilkes, Co-Principal Investigator (PI from 1996-2005). ($501,065 direct costs).

05/1/05 – 04/30/07 The Susan B. Komen Breast Cancer Foundation. Targeting

indoleamine 2,3-dioxygenase to block breast cancer metastasis. Todd Skaar, Ph.D., Principal Investigator, D.S. Wilkes, collaborator. (5% effort) ($250,000 direct costs).

11/1/03 – 10/30/04 A Multicenter, Randomized, Double-blind, Placebo

Controlled Trial Evaluating the Safety and Efficacy of Infliximab (Remicade) in Subjects with Chronic Sarcoidosis with Pulmonary Involvement (Protocol C0168T48) – Centocor. David S. Wilkes, Principal Investigator at Indiana University.

9/1/03 – 8/31/05 National Institutes of Health – Sub-award (MS628608901)

from the Concept Proposal to Planning Regional Center of Excellence for Biodefense (PRCE) at the Univ. of Minnesota. Vaccinia Virus and Pulmonary Immunity. David S. Wilkes, Principal Investigator ($60,000 direct costs).

09/30/2001-6/29/05 National Institute of Health – 1RO1 Grant no.:

RO1HL65170 HL65170- “Molecular Pathology of Pneumocystis Pneumonia”. Chao-Hung Lee, Principal Investigator, D.S. Wilkes, collaborator. ($700,000 direct costs).

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08/01/01-07/30/06* National Institute of Health – R21 HL69727 – “Innovative

Methods for Immune Tolerance in Lung Transplantation”. David S. Wilkes, Principal Investigator ($450,000 direct costs). (* In no cost extension until 7/30/06).

05/15/99 - 05/14/07* National Institute of Health - 2R01 - HL1AI-60797

“Regulation of Immune Responses in Lung Allograft Rejection”. David S. Wilkes, Principal Investigator. ($2,000,000 direct costs). *In no cost extension until 5/1/08.

03/01/99 - 02/28/03 National Institute of Health - R01 - HL1AI-60797-01A1

“Regulation of Immune Responses in Lung Allograft Rejection”. David S. Wilkes, Principal Investigator. ($990,772 direct costs)

12/01/98 - 09/30/03 National Institutes of Health - RO1 HL62058-01.

"Pulmonary Immune Defenses and Their Regulation: Understanding Dysfunction Associated With HIV Disease". Collaborator (Homer L. Twigg III, M.D. - P.I.).

07/01/96 - 06/30/98 American Lung Association Research Grant. “Role of Humoral Immunity in Lung Allograft Rejection”. David S. Wilkes, Principal Investigator. ($50,000 direct costs). 12/94 - 11/96 National Institutes of Health, Multipurpose Arthritis and

Musculoskeletal Diseases Center Grant. Indiana University School of Medicine; "Role of Type V Collagen in Lung Allograft Rejection," David S. Wilkes, Collaborator. ($67,500 direct costs).

05/01/94 - 04/30/05 National Institutes of Health - T35 HL07802. “Short Term

Training for Minority Students in Biomedical Research”. David S. Wilkes, PI

07/92 - 06/96 Harold Amos Medical Faculty Development Award.

Robert Wood Johnson Foundation. “Regulation of B Cells in Human Lung”. David S. Wilkes, Principal Investigator ($300,000).

TEACHING ASSIGNMENTS: (since 2000) 2008 “Regulatory T cells” Immunology course J840 –Dept of Microbiology and

Immunology. Graduate School. Indiana University School of Medicine

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2006 “Regulatory T cells” Immunology course J840 –Dept of Microbiology and Immunology. Graduate School. Indiana University School of Medicine

“Introduction to Immunology” Department of Pharmacology/Toxicology, Graduate School. Indiana University School of Medicine. 2005 “Granulomatous Lung Disease”. Presented to Internal Medicine Residents and

Pulmonary Fellows, Indiana University School of Medicine. “Introduction to Immunology” Department of Pharmacology/Toxicology, Graduate School. Indiana University School of Medicine. 2004 “Interstitial Lung Disease”. Presented to Internal Medicine Residents and

Pulmonary Fellows, Indiana University School of Medicine. “Regulatory T cells” Immunology course J840 –Dept of Microbiology and

Immunology. Graduate School. Indiana University School of Medicine 2003 “Interstitial Lung Disease”. Presented to Internal Medicine Residents Indiana

University School of Medicine. 2002 “Interstitial Lung Disease”. Presented to Internal Medicine Residents Indiana

University School of Medicine. 2001 “Interstitial Lung Disease”. Presented to Internal Medicine Residents Indiana

University School of Medicine. 2000 “Interstitial Lung Disease”. Presented to Pulmonary Fellows at Indiana University

School of Medicine. RESEARCH/STUDENT PROCTORING: Ph.D. Thesis Advisor 2011-present Pankita Pandya. Graduate student, Department of Microbiology and Immunology, Indiana University School of Medicine 2006-2012 Jeremy Lott, M.S. Ph.D. Candidate, Department of Microbiology and

Immunology, Indiana University School of Medicine. Ph.D. awarded 2012. Current position: Post doctoral fellow University of Pittsburgh School of Medicine.

2006-2009 Heather Benson, M.S. Ph.D. Candidate, Department of Biochemistry,

Indiana University School of Medicine. Outstanding Poster - Dept of Biochemistry 2007, Indiana Univ. School of Medicine. PhD received 2009. Post doctoral fellow, Indiana University School of Medicine 2009 -2011. Current position: Medical student IU School of Medicine

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2003 – 2006 Thesis Advisor for Tina Sumpter – Ph.D. Candidate, Department of

Microbiology and Immunology – Indiana University School of Medicine. Indiana University Graduate School Travel Fellowship Award Recipient-

2004. Supported by NIH/NIAID grant T32 Immunology and Infectious Diseases training grant (J.S. Blum, P.I.). Ph.D. Awarded 2006. Current position – Assistant Scientist, Univ. Pittsburgh School of Medicine.

2002 – 2005 Allison Thiele, M.S. – Ph.D. Candidate, Department of Microbiology and

Immunology – Indiana University School of Medicine Recipient of Educational Enhancement Grant Travel Award from Indiana

University Purdue University, and Travel Fellowship from the Indiana University School of Medicine Graduate School – 2003.

Recipient of the Canadian Institutes of Health Research (CIHR) Doctoral Research Award

Indiana University Graduate School Travel Fellowship Award Recipient- 2004

Ph.D. awarded 2005 – current position: OB/GYN fellow, maternal fetal medicine, Univ. British Columbia, Canada

1998- 2003 Kena Swanson - Ph.D. Candidate - Department of Microbiology and

Immunology - Indiana University School of Medicine. Awarded Fall Educational Enhancement Grant 2001, and Indiana University School of Medicine Department of Microbiology and Immunology Edward Shrigley Travel Award in 2002.

First place prize awarded for Sigma Xi Research Competition – 2002. Post-Doctoral fellow, National Institutes of Health - Rocky Mountain

Laboratories, Hamilton, MT. Advisor: Harlan Caldwell, PhD. Current position: Pfizer pharmaceuticals.

Ph.D. Dissertation Committees – Muithi M. Mwanthi (MD, PhD candidate 2009-2012. Ph.D. completed)

Masaaki Sato (PhD candidate, 2008 – Univ. Toronto School of Medicine, external reviewer – PhD awarded 2008) A. Million (Ph.D. candidate 2006 – 2008. Completed 2006)

Anubhav Mathur (2004 – 2006 – Ph.D. Completed 2006) Norman Yeh (M.D., Ph.D. candidate 2005 – 2009, PhD completed 2009)

Andrew Faber (2002 – 2003 – Masters completed) Patrick O’Donnell (M.D. Ph.D. candidate 2001 – 2004, Ph.D. completed)

Depts. Of Microbiology and Immunology, Pharmacology Tonya Roberts (1998 – 2003 – Ph.D. completed)

Hui Lin (1997 – 2002 – Ph.D. completed)

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LABORATORY PROCTORING 2012-Present Qing Yu, Ph.D., Assistant Research Scientist, Center for Immunobiology,

Division of Pulmonary/Critical Care Medicine, Indiana University School of Medicine.

2012-Present Daniel J. Weber, M.D. Third year surgery resident, post doctoral fellow.

Indiana University School of Medicine. 2011-Present Amir Emtiazjoo MD. Postdoctoral Pulmonary Fellow 2008-Present Ragini Vittal, PhD. Assistant Research Scientist, Center for

Immunobiology, Division of Pulmonary Medicine, Indiana University School of Medicine.

2010-2012 Rebecca Shilling, MD, Associate Professor of Medicine, Center for

Immunobiology, Division of Pulmonary Medicine, Indiana University School of Medicine. Current position: Associate Professor of Medicine, University of Illinois School of Medicine.

2010-2012 Hidemi Suzuki, MD, Post Doctoral Research Fellow, Chiba University,

Japan. Current position. Faculty, Chiba University Department of Surgery, Japan

2009-2010 W. Graham Carlos, MD, Post Doctoral Pulmonary Fellow. Clinical

Assistant Professor of Medicine, Pulmonary division, Indiana University School of Medicine

2009-2011 Lin Fan, MD, Post Doctoral Research Fellow, Current position, Faculty,

Department of General Surgery, The First hospital, Xi'an Jiaotong University School of Medicine, China. Current position: Faculty, The First hospital, Xi'an Jiaotong University School of Medicine Department of Surgery.

2007-2009 Yoshito Yamada, M.D. Ph.D. Visiting Post Doctoral Fellow in Thoracic

Surgery, Chiba University, Japan. Current position: Faculty, Chiba University Department of Surgery, Japan

2006 – 2009 Alexander Philipovskiy, Ph.D. Post Doctoral Fellow. 2006 – 2008 Babar Kahn, MD. Hospitalist, Wishard Memorial Hospital, IU Medical

Center. Current position: Assistant Professor of Medicine, Pulmonary division, Indiana University School of Medicine

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2005 – 2007 Masako Iwata, M.D. Visiting Post Doctoral Fellow in Thoracic Surgery, Chiba University, Japan. Current position: Faculty, Chiba University Department of Surgery.

2005 – 2007 Take Iwata, M.D. Visiting Post Doctoral Fellow in Thoracic Surgery,

Chiba University, Japan. Current position: Faculty, Chiba University Department of Surgery.

2004-2006 Michael Duncan, M.D. - Post Doctoral Fellow in Pulmonary and Critical

Care Medicine, Indiana University School of Medicine. Current Position: Thoracic Transplant Program, Indiana University Health

2003 – 2005 Tonya Roberts, Ph.D. – Post Doctoral Fellow – Department of Medicine,

Indiana University School of Medicine. Supported by T32 HL07910 (H. L. Broxmeyer, PI). Current position: Asst. Prof. Dept of Micro/Immuno, Univ. of Maryland School of Medicine.

2003 – 2005 Karen Wood, M.D. – Assistant Professor of Medicine, Division of

Pulmonary and Critical Medicine. KO8 awardee 6/1/05 – “Lung Alloimmunity after Bone Marrow Transplantation”. D.S. Wilkes – Advisor. Current position: Assistant Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Ohio State University School of Medicine

2003 – 2005 Shigeto Yoshida, M.D., Ph.D. – Visiting Post Doctoral Fellow in

Thoracic Surgery, Chiba University, Japan. Current position. Vice Chairman, Dept. of Surgery, Chiba University School of Medicine, Chiba, Japan.

2001 – 2003 David Roe, M.D. – Post Doctoral Fellow in Pulmonary and Critical Care

Medicine, Indiana University School of Medicine. Current position: Medical Director, Lung Transplant Program, Indiana University Health.

2001- 2003 Teruaki Mizobuchi, M.D., Ph.D. – Visiting Post Doctoral Fellow in

Thoracic Surgery, Chiba University, Japan. Current position. Faculty, Dept. of Surgery, Chiba University School of Medicine, Chiba, Japan.

Current position: Faculty, Chiba University School of Medicine, Japan 1999 - 2000 Thomas Ferry, M.D. - Post Doctoral Pulmonary Fellow. 1999-2000 J. Phillip Williams - Undergraduate student. Xavier University, New

Orleans. Current Position: Pediatric Resident, University of Illinois. School of Medicine.

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1999- 2001 Kazuhiro Yasufuku, M.D. - Post Doctoral Fellow in Thoracic Surgery, Chiba University, Japan. Current position – Associate Professor, Dept. of Thoracic Surgery, University of Toronto, Canada.

1998 Kemba Baker MD- Xavier University. Current position. Private practice

pediatrician, Houston, TX. 1996-1998 David Mares, M.D. - Post Doctoral Pulmonary Fellow, Recipient of Glaxo

Wellcome Pulmonary Fellowship Award 1997-1998. Current position: private practice

1996 Kevin Patterson - Undergraduate Student. Villanova University 1995-1998 Yasuo Sekine, M.D., Ph.D. - Post Doctoral Fellow in Thoracic Surgery,

Chiba University, Japan. Current position – Professor, Department of Surgery, University of Tokyo, Japan

1995 David Bowman - Medical Student. Indiana University School of

Medicine. Current position: Assistant Professor of Pediatrics, Univ. of Maryland School of Medicine

1994 Erin Harris - Medical Student. Indiana University School of Medicine.

Current position: private practice SERVICE: Hospital Service 2009-present – Thoracic Transplant Oversight Committee – Chair University Administrative Service 2000 Director of Education - Pulmonary Division, Indiana University School of

Medicine 2000 – 2003 Vice Chairman for Research Department of Internal Medicine, Indiana

University School of Medicine. 1993 - 2008 Residency Advisor for Internal Medicine Residents for the Department of

Internal Medicine, Indiana University School of Medicine 1993 - present Medical Student Advisor, Indiana University School of

Medicine University Committee Service 2013-present Chair, Institutional Advisory Board, IU Simon Cancer Center

22

2011-present Physician Executive Advisory Board, Indiana University MD/MBA Joint Degree Program

2010-present Chair, IU Health Strategic Research Council 2010-2011 Search and Screen Committee for Acting Chief of Staff – Research,

Veterans Administration Hospital, Indianapolis, IN 2009-present Chair, Scientific Advisory Council, IU School of Medicine 2009-present IU Health Research Committee 2009-present Indiana Biobank Steering Committee 2009-present Purdue University Discovery Park Advisory Council 2009 Search and screen committee for Vice President for Research of Indiana

University 2009-present Intellectual Property Policy Council, Indiana University 2007-present Basic Science Council-Indiana Univ. School of Medicine 2007-present MD/PhD Advisory Committee, IU School of Medicine 2005 – 2007 IU School of Medicine Awards Committee 2005 Search and Screen Committee for Associate Dean for Clinical Research – Indiana University School of Medicine 2004 – 2007 Student Research Committee – Indiana University School of Medicine 2003 – 2005 Department of Medicine Promotions and Tenure Committee 2003 - 2005 Search and Screen Committee, Director of Pulmonary Research, Wells

Center, Riley Hospital for Children, Indiana University School of Medicine

2003 - 2004 Search and Screen Committee, Director of HLA laboratory, Department of Medicine, Indiana University School of Medicine

2002 Dean’s Task force for Biostastitics 2002 – 2005 Search and Screen Committee for Chair, Department of Biochemistry,

Indiana University School of Medicine 2002 - 2003 Chair, Search and Screen Committee for Chief, Division of

Rheumatology, Indiana University School of Medicine 2002 Search and Screen Committee for Assistant Dean of Graduate School and

Director of Graduate Office - Indiana University Purdue University at Indianapolis

2001 – 2006 Research III Building Task Force Committee 2001 - 2003 Search and Screen Committee for Chairman of Department of Surgery -

Indiana University School of Medicine 2000-2003 IUPUI Internal Grant Proposal Review Committee 1999 - 2000 Search and Screen Committee for Dean of School of Medicine - Indiana

University School of Medicine 1999 Search and Screen Committee for Associate Dean of Graduate School and

Director of Graduate Office - Indiana University Purdue University at Indianapolis

1996 - 2005 University Medical Diagnostic Associates, Board Member, Indiana University Medical Center

1995 - 2001 Division of Pulmonary/Critical Care Research Committee, Indiana University School of Medicine

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1994 - 1996 Tuberculosis Containment Subcommittee - Wishard Memorial Hospital, Indiana University School of Medicine

1994 - 1996 Consultant for Ronald McNair Post Baccalaureate Program at Indiana University Indianapolis

1994 - 2003 Biomedical Research Committee - Indiana University School of Medicine 1994 - 1999 Task Force on Minority Attainment and Under-representation at Indiana

University School of Medicine 1994 - 2001 Dean's Task Force for Minority Education, Indiana University School of

Medicine 1993 - 1999 Vencor Hospital Board of Directors Medical Staff, monthly meetings 1993 - 1996 Tuberculosis Advisory Subcommittee, Department of Health, State of

Indiana Patient Care Service (since 2000) 2002 – 2008 Director, Clinic for Sarcoidosis and Immunologic Lung Diseases, Indiana

University Medical Center 1992-2007 Attending Physician - Vencor Hospital, Indianapolis 1992 -2011 Attending Physician – IU Health University Hospital, Wishard, and VA

Hospitals, Indianapolis, IN 1992-present Attending Physician – IU Health University Hospital, and Wishard Hospital Professional Service - Indiana 2012 Panelist, Indiana Business Journal Power Breakfast: Indiana Life Sciences 2011 Member, Core Competency Steering Committee, BioCrossroads, Inc. 2011 Guest- “Inside Indiana Business” television show, Indianapolis, IN 2011 “Novel Therapeutics in Lung Transplantation”. Presented to the IU Health Lung

Transplant Support Group 2011 Guest- “Inside Indiana Business” television show, Indianapolis, IN 2010 Delegate, State of Indiana Jobs Mission to China and Japan 2009 Presentation to 100 Black Men, Indianapolis. “Why Biomedical Research is

Important”. 2008 Panel Discussant, Medical Technology Leadership Forum: FDA in the 21st

Century: Issues and Their Impact on Medical Technology. Indianapolis, IN. 2008 Speaker, Indiana Organ Procurement Organization: “The Art and Science of Lung

Transplantation”. 2007 Guest- “Inside Indiana Business” television show, Indianapolis, IN 2007 Panelist: Life Sciences Forum, Indianapolis, IN 2006 “Overview of Sarcoidosis” – Presented to the Central Indiana Sarcoidosis Support

Group 2005 National Public Radio – interview for “Sound Medicine”: “Lung

Transplantation” 2003 Who’s Who in Black Indianapolis 1999-2000 Minority Health Coalition – State of Indiana

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1998-2010 Medical Advisor for the Central Indiana Sarcoidosis Support Group 1997 Channel 13 News - Featured Speaker to Discuss Lung Transplant Immunology

Research 1997 Center for Leadership Development - Invited Presentation on Careers in Medicine 1996 - 1998 Co-chairman - Fund Development and Marketing Committee, American Lung

Association of Indiana 1996 Moderator: Tuberculosis - Diagnosis and Prevention - Panel Discussion.

American Lung Association of Indiana 1995 - 1997 Advisory Board, African Americans for Organ Donation, Indiana Organ

Procurement Organization 1995 Smoking & Pregnancy - Channel 13 News - Invited guest 1994 - 1996 Professional Education & Research Committee for American Lung Association of

Indiana 1994 “Health News" - Channel 13 News - Invited guest to discuss "Deep venous

thrombosis and pulmonary emboli" 1994 “Health Talk” - Channel 16 TV Show - Tuberculosis 1993 - 1998 American Lung Association of Indiana Executive Committee 1993 - 1995 Coordinator, Marion County High School Underprivileged Students Summer

Internship Program 1992 - 1996 State Representative for Indiana Tuberculosis Advisory Board, Indiana

Department of Health OTHER PROFESSIONAL ACTIVITIES: 2013 -White Coat Ceremony speaker, Indiana University School of Medicine.

“Professionalism in Medicine: Providing Comfort to our Patients” 2012 -“Careers in Academic Medicine” – Leaders in Academic Medicine

Program, Indiana University School of Medicine 2011 -Invited speaker: “A Career in Science and Medicine – One Man’s

Journey”. Student National Medical Association National Convention. -Invited speaker: “A Career in Science and Medicine – One Man’s

Journey”. Presented to the Department of Medicine Residents at Temple University School of Medicine, Philadelphia, PA.

-“The Art and Science of Lung Transplantation”, Department of Pathology Grand Rounds, Indiana University School of Medicine.

-“Lung Transplantation: Are we there yet?”, Department of Medicine Grand Rounds, Indiana University School of Medicine.

2010 -“The Autoimmune Basis of Lung Allograft Rejection”. Division of Pulmonary and Critical Care Medicine, Indiana University School of Medicine.

-“The Role of IL-17 in EMT and Obliterative Bronchiolitis in Lung Transplant Rejection”. Plenary Speaker, American Transplant Congress International Meeting, San Diego, CA.

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-American Thoracic Society International Meeting, New Orleans, LA, Invited Speaker Presentations: “Opportunistic Pulmonary Infections in Transplant Patients”, Developing a Scientific Career”, “Role of IL17 in Lung Transplant Rejection”, “Role of Matrix Metalloproteinases in T Cell Activation”.

-“Why Biomedical Research is Important”, presented to the Indiana Legislative Black Caucus.

2008 Presentation: “Pulmonary Host Defense in Against Infections in Transplant Recipients”, Co-Chair - “Clinical Year in Review”, Co- Chair – Bronchiolitis Obliterans Following Lung Transplantation: What are its Causes and What can we do about it”. American Thoracic Society international meeting, Toronto, Canada.

- “Role of Autoimmunity to Type V Collagen in the Pathogenesis of Lung Allograft Rejection”. Department of Microbiology and Immunology Research Conference, Indiana University School of Medicine.

-“Biomarkers of Lung Transplant Rejection”. Division of Clinical Pharmacology, Dept. of Medicine. Indiana Univ. School of Medicine.

-“Autoimmunity to Type V Collagen in the Pathogenesis of Lung Transplant Rejection”. Department of Pharmacology and Toxicology lecture series. Indiana University School of Medicine.

2007 “Grant Budgeting Basics” – Post Graduate Course – American Thoracic

Society International Meeting, San Francisco, CA. 2006 Invited Speaker - “Role of Autoimmunity to Type V Collagen in the

Pathogenesis of Chronic n Lung Allograft Rejection” Department of Microbiology/Immunology, Indiana University School of Medicine

2005 American Thoracic Society International Meeting: Co-Chair: Poster Discussion Session – “Lung Transplantation Biology”.

2005 International Society for Heart and Lung Transplantation annual meeting. Co-Chair; Oral presentation session – Immunobiology in Lung Transplantation.

2004 Host: Great Lakes Transplant Immunology Forum. Indiana University School of Medicine.

2004 Division of Pediatric Pulmonary Medicine Research Conference – Indiana University School of Medicine – Division of Pulmonary and Critical Medicine. “The Role of Autoimmunity to Type V Collagen in the Pathogenesis of Lung Allograft Rejection”.

2004 “Role of Indolamine 2,3 Dioxygenase in Lung Dendritic Cell-induced Regulation of Immune Responses”. Clinical Pharmacology Research Conference, Indiana University School of Medicine.

2003 “Effects of Smoking in Women” Presented at Brebeuf High School, Indianapolis, IN.

2003 “Overview of Sarcoidosis” – Presented to the Central Indiana Sarcoidosis Support Group Conference

2002 Department of Medicine Grand Rounds, Indiana University School of Medicine. “The Art and Science of Lung Transplantation”

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2002 American Thoracic Society International Meeting: Oral Presentations: Faculty, Post Graduate Course - “Opportunistic Pulmonary Infections in Transplantation”

“Role of Indolamine 2,3 Dioxygenase in Lung Dendritic Cell-induced Regulation of Immune Responses”

“Type V Collagen-specific T cells Exacerbate Lung Allograft Rejection” 2001 Division of Rheumatology Grand Rounds, Indiana University School of

Medicine: “A Role for Autoimmunity in the Pathogenesis of Lung Allograft Rejection”.

2000 Faculty, Post Graduate Course - “Opportunistic Pulmonary Infections in Transplantation” - American Thoracic Society International Meeting.

1999 Co-chair of Symposium - "Immune Modulators and Mediators" - American Thoracic Society National Meeting

1999 Chairman of symposium - "Pathogenesis of Lung Allograft Rejection: - American Thoracic Society National Meeting

1998 Co-Chairman of Symposium - "Cytokines and Inflammation". Midwestern Meeting of American Federation for Medical Research

1998 Faculty, Post-Graduate Course. “Opportunistic Infections in Transplantation". American Thoracic Society National Meeting

1998 Co-chair - Symposium: “Adhesion Molecules and Co-stimulatory Molecules”. American Thoracic Society National Meeting

1997 “Do Donor Alveolar Macrophages Have A Role In The Pathogenesis of Acute Lung Allograft Rejection?” Pulmonary Research Conference. Indiana University School of Medicine

1996 Co-Chairman, Lung Transplantation Symposium, American Lung Association, American Thoracic Society International Conference

1995 - 2000 Co-Director - Immunology Journal Club. Department of Microbiology and Immunology, Indiana University School of Medicine

1992 Co-Chairman, Poster discussion session. “Mechanisms of Inflammatory and immune reactions. American Lung Association/American Thoracic Association.

PUBLICATIONS: Research – Investigation R = refereed journals R1. Wilkes, D.S., B. Carabello, A. Diamond, and B. Donner: Variant angina in an 11 year

old boy. J. Am.College Cardiol. 1985. 5(3):761. PMID: 3973275. R2. Yarbrough, Jr., W.C., D.S. Wilkes, and J.C. Weissler: Human alveolar macrophages

inhibit receptor-mediated increases in intracellular calcium concentration in lymphocytes. Am. J. Respir. Cell. Mol. Biol. 1991. 5:411-415. PMID: 1657060.

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R3. Wilkes, D.S., W.C. Yarbrough, and J.C. Weissler: Human alveolar macrophages inhibit immunoglobulin production in response to direct B cell mitogen. Am. J. Respir. Cell. Mol. Biol. 1993. 9 (2):141-147. PMID: 8338683.

R4. Wilkes, D.S., and J.C. Weissler: Alloantigen induced immunoglobulin production in

human lung: Differential effects of accessory cell populations on IgG synthesis. Am. J. Respir. Cell. Mol. Biol. 1994. 10:339-346. PMID: 8117452.

R5. Yarbrough, Jr., W.C., D.S. Wilkes, and J.C. Weissler: Inhibition of lymphokine-

activated killer cells by human pulmonary macrophages: Discordance between up-regulation of the beta chain (p75) of the interleukin-2 receptor on CD56+ cells and limited response to interleukin-2. Am. J. Respir. Cell. Mol. Biol. 1994. 10(2):184-191. PMID: 7509162.

R6. Twigg H.L. III, D.S. Wilkes, and D.M. Soliman: Measurement of IL-6 inhibitory

activity in cultured cell supernatants and lysates. J. Lab. Clin. Med. 1994. 124(2):283-292. PMID: 8051493.

R7. Wilkes D.S., K.M. Heidler, M. Niemeier, R. Schwenk, P.N. Mathur, W.M. Breite,

O.C. Cummings, and J.C. Weissler: Increased bronchoalveolar IgG2/IgG1 ratio is a marker for human lung allograft rejection. J. Investigative Med.1994. 42(2):652-659. PMID: 8521028.

R8. Wilkes D.S., K.M. Heidler, W.M. Quinlan, N.A. Doyle, and C.M. Doerschuk:

Allogeneic alveolar bronchoalveolar lavage cells induce the histology of acute lung allograft rejection and stimulate selective IgG2a production in recipient murine lungs. J. Immunol. 1995. 155:2775-2783. PMID: 7650403.

R9. Wilkes, D.S., M. Neimeier, P.M. Mathur, D.M. Soliman, H.L. Twigg, L.K. Bowen,

K.M. Heidler: Effect of human lung allograft alveolar macrophages on IgG production. Immunoregulatory role of interleukin-10, transforming growth factor-�, and interleukin-6. Am. J. Resp. Cell Mol. Biol. 1995. 13(5):621-628. PMID: 7576699.

R10. Gilbert-McClain L. and D.S. Wilkes. Non-pulmonary complications of sarcoidosis.

Clin Pulm Med .1996. 3(3):164-171. R11. Pascuzzi, R.M., S.A. Shapiro, A.N. Rau, C.E. Schultz, R.M. Bowman, K.S.

Caldemeyer, and D.S. Wilkes. Sarcoid Myelopathy. J. Neuroimaging. 1996. 6:61-62. PMID: 8555667.

R12. Twigg H.L., B.A. Spain, D.M. Soliman, L.K. Bowen, K.M. Heidler, and D.S. Wilkes.

Impaired IgG production in the lungs of HIV-infected individuals. Cell Immunol. 1996. 170:127-133. PMID: 8660808.

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R13. Wilkes D.S., R.A. Sidner, P.N. Mathur, M. Niemeier, R. Schwenk, K.M. Heidler, and L.K. Bowen. Preferential production of IgG2 antibodies by parenchymal lung B-lymphocytes during lung allograft rejection. Transplant Proc. 1997. 29:1891-1895. PMID: 9142313.

R14. Sekine, Y., L.K. Bowen, K.M. Heidler, N. Van Rooijen, J.W. Brown, O.W.

Cummings, and D.S. Wilkes. Role of passenger leukocytes in allograft rejection: effect of depletion of donor alveolar macrophages on the local production of TNF-�, Th1/Th2 cytokines, IgG subclasses, and pathology in a rat model of lung transplantation. J. Immunol. 1997. 159:4084-4093. PMID: 9378999.

R15. Wilkes, D.S., L.K. Thompson, S. Bragg, and K.M. Heidler. Instillation of allogeneic

lung dendritic cells and alveolar macrophages have differential effects on the stimulation of gamma interferon production and lymphocytic bronchitis and vasculitis in recipient murine lungs. J. Leuk. Biol. 1998. 64:578-586. PMID: 9823761.

R16. Mares, D.C. and D.S. Wilkes. Bronchoscopy in the diagnosis of respiratory

infections. Curr Opin Pulm Med.1998. 4:123-129. PMID: 9675513. R17. Twigg, H.L. III, B.A. Spain, D.M. Soliman, K. Knox, R.A. Sidner, C, Schnizlein-

Bick, D.S. Wilkes, G.K. Iwamoto. Production of interferon-�gamma by lung lymphocytes in HIV-infected individuals. Am. J. Physiol. 1999. 276 (Lung Cell. Mol. Physiol. 20):L256-L262. PMID: 9950887.

R18. Wilkes, D. S., D. Bowman, O.W. Cummings, K.M. Heidler. Allogeneic

bronchoalveolar lavage cells induce the histology and immunology of lung allograft rejection in recipient murine lungs: role of ICAM-1 on donor cells. Transplantation. 1999. 67:890-896. PMID: 10199739.

R19. Twigg, H.L. III, D.M. Soliman, R.B. Day, K. Knox, R. Anderson, D.S. Wilkes, C. T.

Schnizlein-Bick. Lymphocytic alveolitis, bronchoalveolar lavage viral load, and outcome in HIV-infection. Am. J. Respir. Care and Crit. Care Med. 1999. 159(5):1439-1444. PMID: 10228108.

R20. Mares, D.C., K.M. Heidler, G.N. Smith, O.W. Cummings, E.R. Harris, Foresman, B.,

D.S. Wilkes. Type V collagen modulates alloantigen-induced pathology and immunology in the lung. Am. J. Respir. Cell. Mol. Biol. 2000. 23:62-70. PMID: 10873154.

R21. Heidler, K.M., K. Baker, K. Woods, C. Schnizlein-Bick, O.W. Cummings, R. Sidner,

B. Foresman, D. S. Wilkes.. Instillation of allogeneic lung antigen presenting cells deficient in expression of MHC class I or II antigens have differential effects on local cellular and humoral immunity, and pathology in recipient murine lungs. Am. J. Respir. Cell. Mol. Biol. 2000. 23:499-505. PMID: 11017915.

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R22. Sekine, Y., K. Yasufuku, K.M. Heidler, O.W. Cummings, Brown, J., N. Van Rooijen, R. Fujisawa, D. S. Wilkes. MCP-1 and RANTES are chemotactic for graft infiltrating lymphocytes during acute lung allograft rejection. Am. J. Respir. Cell. Mol. Biol. 2000. 23:719-726. PMID: 11104723.

R23. Wilkes, D.S. and H.L. Twigg III. B-lymphocytes in the lung- a topic to be revisited.

Sarcoidosis, Vasculitis and Diffuse Lung Disease. 2001. 18:34-49. PMID: 11354546. R24. Yasufuku, K., K.M. Heidler, P.W. O’Donnell, G.N. Smith Jr., O.W. Cummings, B.H.

Foresman, T. Fujisawa, D.S. Wilkes. Oral tolerance induction by type V collagen down-regulates lung allograft rejection. 2001 Am. J. Respir. Cell Mol. Biol. 25:26-34. PMID: 11472972.

R25. Yasufuku, K., K.M. Heidler, K.A. Woods, G.N. Smith Jr., O.W. Cummings T.

Fujisawa, D.S. Wilkes. Prevention of bronchiolitis obliterans in rat lung allografts by type V collagen-induced oral tolerance. Transplantation. 2002. 73:500-505. PMID: 11889419.

R26. K. S. Knox , O.W. Cummings, Behnia, M., M. Busk, D.S. Wilkes. Acute Graft-

versus-host disease presenting as an isolated lymphocytic bronchiolitis following liver transplantation. Liver Transplantation. 2002. 8:968-971. PMID: 12360443.

R27. Haque, M., T. Mizobuchi, K. Yasufuku, T. Fujisawa, R. Brutkiewicz, Y. Zheng, K.

Woods, G. N. Smith, O. W. Cummings, K. M. Heidler, J. S. Blum, D.S. Wilkes. Evidence for Immune Responses to a Self-antigen in Lung Transplantation: Role of Type V Collagen-specific T Cells in the Pathogenesis of Lung Allograft Rejection. J. Immunol. 2002. 169:1542–1549. PMID: 12133982.

R28. Wilkes, D.S. Role of Autoimmunity in the Pathogenesis of Lung Allograft Rejection.

Invited Review. Archivum Immunologiae et Therapiae Experimentalis. 2003. 51:227-230. PMID: 12956431.

R29. Wilkes, D.S. Autoimmune Responses to Grafted Lungs: Immune Responses to a

Native Collagen – Type V Collagen. Graft. 2003. 6:42-49. PMID: R30. Zhang, S., G. Zeng, D. S. Wilkes, G. E. Reed, R. C. McGarry, J. N. Eble, L. Cheng.

Dendritic Cells Transfected with IL-12 and Pulsed with Tumor Extract Suppressed Growth of Murine Prostatic Carcinoma In Vivo. The Prostate. 55:292-298, 2003. PMID: 12712408.

R31. Mizobuchi, T, Yasufuku, K., K. M. Heidler, K.Woods, G. N. Smith Jr., O. W.

Cummings, J. Blum, T. Fujisawa, D.S. Wilkes. Differential Expression of Smad7 Transcripts Identify the CD4+CD45RChi Regulatory T Cells that Mediate Type V Collagen-induced Tolerance to Lung Allografts. J. Immunol. 2003. 171:1140-1147. PMID: 12874199.

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R32. Gordon, S.B., D.E. Miller, M. Chaponda, R.B. Day, T. Ferry, D.S. Wilkes, C. Schnizlein-Bick, R.C. Read, M.E. Molyneux, H.L. Twigg III. Pulmonary humoral responses to Streptococcus pneumonia are altered in HIV-infected Malawian adults. J. Infect. Dis. 2003. 188:666-70. PMID: 12934182.

R33. Mizobuchi, T., Y. Sekine, K. Yasufuku, T. Fujisawa, and D.S. Wilkes. Comparison

of Surgical Procedures for Vascular and Airway Anastomoses that Utilize a “Modified” Non-Suture External Cuff Technique for Experimental Lung Transplantation in Rats. J. Heart and Lung Transplant. 2004, 23:889-903. PMID: 15261185.

R34. Swanson, K.A., Y. Zheng, K. M. Heilder, T. Mizobuchi, and D.S. Wilkes. CD11c+

Cells Modulate Pulmonary Immune Responses by Production of Indoleamine 2,3-dioxygenase. Am. J. Respir. Cell Mol. Biol. 2004, 30:311-318. PMID: 12959949.

R35. Sumpter, T. Roberts, T.J., and D. S. Wilkes. Interface between Alloimmunity and

Autoimmunity in Organ Transplantation. Current Opinion in Organ Transplantation. 2004. 9:23-28.

R36. Sumpter, T. and D. S. Wilkes. The Role of Autoimmunity to Organ Allograft

Rejection: A Focus on Immunity to Type V Collagen in the Pathogenesis of Lung Transplant Rejection. Amer. J. Physiol.: Lung Molec. Physiol. 2004. 286(6):L1129-39. PMID: 15136293.

R37. Sumpter, T. and D. S. Wilkes. Tolerance to Autoantigens. Current Opinion in Organ

Transplantation. 2004. 9:246-251. R38. Sumpter, T. and D. S. Wilkes. The Role of Regulatory T Cells in the Pathogenesis of

Lung Allograft Rejection. Current Opinion in Organ Transplantation. 2004. 9:314-319.

R39. Swanson, K.A., Y. Zheng, K.M. Heidler, Z. Zhang, T. Roberts, and D.S. Wilkes.

Flt3L, IL-4, GM-CSF, and Adherence-mediated isolation of Murine Lung Dendritic Cells: Assessment of Isolation Technique on Phenotype and Function. Journal of Immunology. 2004. 173:4875-81. PMID: 15470028.

R40. Roberts, S.D., L.M. Kohli, D.S. Wilkes, K.S. Knox. CD4+/CD28- Lymphocytes are

Expanded in Sarcoidosis. Sarcoidosis, Vasculitis and Diffuse Lung Disease. 2005; 22: 13-19. PMID: 15881275.

R41. Roe, D.W., J. Fehrenbacher, M.Niemeier, C. Labarrere, M. Zeiger, and D.S. Wilkes.

Lung Preservation: Pulmonary Flush Route Affects Bronchial Mucosal Temperature and Expression of IFN-γ and Gro in Regional Lymph Nodes. American Journal of Transplantation. 2005. 5:995 – 1001. PMID: 15816879.

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R42. Wilkes, D.S., T. M.Egan, H.Y. Reynolds. Lung Transplantation: Opportunities for Research and Clinical Advancement. Am J Respir Crit Care Med. 2005 October 15; 172(8):944-955. PMCID:PMC2718411.

R43. Roberts-Webb, T., T.L. Sumpter, A.T. Thiele, K.A. Swanson, D. S. Wilkes.

Phenotype and Function of Lung Dendritic Cells. Critical Reviews in Immunology. 2005. 25:465-491. PMID: 16390323.

R44. Duncan, M.D., D.S. Wilkes. Transplant Related Immunosuppression: A Review of

Immunosuppression and Pulmonary Infections. Proc Am Thorac Soc. 2005 December; 2(5):449-455. PMCID:PMC2713333.

R45. Thiele, A.T., Sumpter, T.L., Walker, J.A., Xu, Q, Chang, C., Bacallao, and D.S.

Wilkes. JVI Spotlight: Pulmonary Immunity to Viral Infection: Adenoviral Infection of Lung Dendritic Cells Renders T cells Non-responsive to IL-2. Journal of Virology. 2006 February: 80(4):1826-1836. PMCID:PMC1367134.

R46. Yoshida, S., A. Haque, T. Mizobuchi, T. Iwata, M. Chiyo, T. J. Webb, L. A. Baldridge,

K. M. Heidler, O. W. Cummings, T. Fujisawa, J. S. Blum, D., D. Brand, D. S. Wilkes. Anti-type V Collagen Lymphocytes that Express IL-17 and IL-23 Induce Rejection Pathology in Fresh and Well-healed Lung Transplants. American Journal of Transplantation. 2006. 6:724-735. PMID: 16539629.

R47. Wilkes, D.S. and T. Roberts-Webb. CD11/CD18. Encyclopedia of Respiratory

Medicine. Editors: Geoffrey J. Laurent and Steven D. Shapiro. Pages 338 – 342. 2006. Elsevier Ltd.

R48. Kahi, C.M., S. Romil, M Temkit, K. Canlas, S. Roberts, K. Knox, D. S. Wilkes, P.

Kwo. Hepatobiliary Disease in Sarcoidosis. Sarcoidosis, Vasculitis and Diffuse Lung Disease. 2006. 23:117-123.

R49. Benichou, G., A. Alessandrini, R. Charrad. D.S. Wilkes. Induction of Autoimmunity

after Allotransplantation. Frontiers in Bioscience. 2007. 12:4362-4369. PMID: 17485380.

R50. Hong, L., T.J. Webb, D.S. Wilkes. Dendritic Cell – T Cell Interactions: CD8αα

Expressed on Dendritic Cells Regulates T Cell Proliferation. Immunology Letters. Author manuscript; available in PMC 2008 February 15. Published in final edited form as: Immunol Lett. 2007 February 15; 108(2):174-178. PMCID:PMC1910694.

R51. Yoshida, S., T. Iwata, M. Chiyo, G.N. Smith, B.Foresman, E.Mickler, K.M. Heidler, O.

W. Cummings, T. Fujisawa, D.D. Brand, A.Baker, D.S. Wilkes. Metalloproteinase Inhibition has Differential Effects on Alloimmunity, Autoimmunity, and Histopathology in the Transplanted Lung. Transplantation. 2007. 83:799-808. PMID: 17414715.

32

R52. Smith, G.N., E.A. Mickler, K.K. Payne, J.Lee, M. Duncan, J. Reynolds, B. Foresman, D.S. Wilkes. Lung Transplant Metalloproteinase Levels are Elevated Prior to Bronchiolitis Obliterans Syndrome. American J. Transplantation. 2007. 7:1856-1861. PMID: 17524078.

R53. Yao, Y., P. Li, P. Singh, A.T. Thiele, D.S. Wilkes, G. J. Renukaradhya, R.R.

Brutkiewicz, G.D. Luker, S.Hong, J.S. Blum, C. Chang. Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II. Cellular Immunology. Author manuscript; available in PMC 2008 April 1. Published in final edited form as: Cell Immunol. 2007 April; 246(2):92-102PMCID:PMC2100387.

R54. Humphreys,T.L., L. Li, X. Li, D.M. Janowicz, K. R. Fortney,. Q. Zhao, W. Li, J.

McClintick, B. P. Katz, D.S. Wilkes, H.J. Edenberg, S.M. Spinola. Dysregulated Immune Profiles in Skin and Dendritic Cells are Associated with Increased Host Susceptibility to Haemophilus ducreyi Infection in Human Volunteers. Infection and Immunity. 2007 December; 75(12):5686-5697. PMCID:PMC2168359.

R55. Banks, K.E., T.L. Humphreys, B.P. Katz, D.S. Wilkes, S.M. Spinola. Haemophilus

ducreyi Partially Activates Human Myeloid Dendritic Cells. Infection and Immunity. 2007 December; 75(12):5678-5685. PMCID:PMC2168323.

R56. Burlingham, W.J., R.B. Love, L. D. Haynes, E. Jankowska-Gan, K. C. Meyer, M. S.

Hayney, R. K. Braun, J. L. Bobadilla, B. Gopalakrishnan, D. S. Greenspan, G. Leverson, A. Munoz, J. Reynolds, M. D. Duncan, K. M. Heidler, L. Hong, S. Yoshida, T. Iwata, J. Lee, D. D. Brand, G. N. Smith Jr., O. W. Cummings, D. S. Wilkes. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. J Clin Invest. 2007 November 1; 117(11):3498-3506.. PMCID:PMC2040314.

R57. Iwata, T, M. Chiyo, S. Yoshida, G.N. Smith Jr., E.A. Mickler, R. Presson Jr., A.J.

Fisher, T. Fujisawa, D.D. Brand, O.W. Cummings, K.M. Heidler, D.S. Wilkes. Lung Transplant Ischemia-Reperfusion Injury: MMP Inhibition Down Regulates Exposure of Type V Collagen, GRO-induced Neutrophil Chemotaxis, and TNF-α Expression. Transplantation. 2008 Feb 15; 85(3):417-426. PMID: 18322435

R58. Chiyo, M, T. Iwata, T.J. Webb , M.R.Vasko, E.L. Thompson. K..M. Heidler, O.W.

Cummings, S. Yoshida, T. Fujisawa, D.D. Brand, D.S. Wilkes. Silencing S1P1 Receptors Regulates Collagen-V Reactive Lymphocyte-mediated Immunobiology in the Transplanted Lung. American Journal of Transplantation. 2008 Mar; 8(3):537-46. PMID: 18294150.

R59. Sumpter, T.L., K.K. Payne, D.S. Wilkes. Regulation of the NFAT Pathway

Discriminates CD4+CD25+ Regulatory T Cells from CD4+CD25- Helper T Cells. Journal of Leukocyte Biology. 2008 Mar; 83(3):708-17. Epub 2007 Nov 21. PMID: 18032693.

33

R60. Bobadilla, J.L., R.B. Love, E. Jankowska-Gan, L.D. Haynes, R.K. Braun, M.S. Hayney, A.M. del Rio, D.S. Greenspan, K.M. Heidler, O.W. Cummings,T. Iwata, D. Brand, R. Presson, W.J. Burlingham, D.S. Wilkes. Th-17 Monokines, Collagen Type V and Primary Graft Dysfunction in Lung Transplantation. Am J Respir Crit Care Med. 2008 March 15; 177(6):660-668. PMCID:PMC2267340.

R61. Khan, B.A., M. Duncan, J. Reynolds, D.S. Wilkes, Nocardia infection in lung transplant recipients. Clin. Transplantation. 2008 . Sep-Oct;22(5):562-6. PMID:18435787

R62. Murata, K., T. Iwata, S. Nakashima, K. Fox-Talbot, Z. Qian, D.S. Wilkes, W. M. Baldwin. C4d Deposition and Cellular Infiltrates as Markers of Acute Rejection in Rat Models of Orthotopic Lung Transplantation. March 23.: Transplantation. 2008 July 15; 86(1):123.129. PMCID:PMC2659637.

R63. Moss, M., Wilkes, D.S., Waire, Lorraine B. Clinical Year in Review II. Pulmonary

Infections in the Immunocompetent Host, Issues in the Training of Fellows and Residents, Asthma, and Chronic Obstructive Pulmonary Disease. Proceedings of the American Thoracic Society. 2008. 5:745-50.

R64. Wilkes, D.S. Clinical Year in Review III: Interstitial Lung Disease, Occupational Lung

Disease, Pulmonary Vascular Disease, Lung Transplantation. Proceedings of the American Thoracic Society. 2008.5:751-4.

R65. Judson MA, Baughman RP, Costabel U, Flavin S, Lo KH, Kavuru MS, Drent M, Baughman RP, Kavuru MS, Culver DA, Davis GS, Fogarty CM, Judson MA, Hunninghake GW, Teirstein AS, Mandel M, McNally D, Tanoue L, Newman L, Wasfi Y, Patrick H, Rossman MD, Raghu G, Sharma O, Wilkes D, Yeager H, Donahue JF, Kaye M, Sweiss N, Vetter N, Thomeer M, Brutsche M, Nicod L, Valeyre D, Chanez P, Albera C, Drent M, Grutters J, Hoogsteden H, Costabel U, Muller-Quernheim J, Bonnet R, Kanniess F. Efficacy of Infliximab in Extrapulmonary Sarcoidosis: Results from a Randomised Trial. Eur Respir J. 2008. 6:1189-96.

R66. Iwata, T. A. Philipovskiy, A.J. Fisher, R.G. Presson Jr., M. Chiyo, J. Lee, E. Mickler,

G.N. Smith I. Petrache, D.B. Brand, W. Burlingham, B. Gopalakrishnan, D. S. Greenspan, J. Christie, D.S. Wilkes. Anti-type V Collagen Humoral Immunity in Lung Transplant Primary Graft Dysfunction. Journal of Immunology. 15;181:5738-5747. PMCID: PMC2997998.

R67. Qu P, Du H, D.S. Wilkes, Yan C. Critical Role of Lysosomal Acid Lipase in T Cell Development and Function. American J. Pathology. 2009 March; 174(3):944-956. PMCID:PMC2665754.

R68. Shilling, R.S., D. S. Wilkes. Immunobiology of Chronic Lung Allograft Dysfunction: New Insights from the Bench and Beyond. American J. Transplantation. Author manuscript; available in PMC 2010 August 1. Published in final form as: Am J Transplant. 2009 August; 9(8): 1714–1718. PMCID: PMC2734467

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R69. Braun, R.K., M. Molitor-Dart, Z. Xiang, S.B. Fain, E Jankowska-Gan, C.M. Seroogy,

W.J. Burlingham, D.S. Wilkes, D.D. Brand, J. Torrealba, R.B. Love. Transfer of tolerance to collagen type V suppresses Th-17 lymphocyte mediated acute lung transplant rejection. Transplantation.Author manuscript; available in PMC 2010 December 27. Published in final edited form as: Transplantation. 2009 December 27; 88(12):1324-1348. PMCID:PMC2804859.

R70. Arefayene, M., S. Phillips, D. Cao, S. Mamidipalli, D.A. Flockhart, D.S. Wilkes, T.C. Skaar. Identification of genetic variants in the human indoleamine 2,3-dioxygenase (indo) gene that have altered enzyme activity. Pharmacogenetics and genomics. 2009 Jun;19(6):464-76. PMID:19514129

R71. Yamada, Y., S. Yoshida, I. Petrache, H. Benson, D. Brand, I. Yoshino, Y. Sekine, D.S. Wilkes. Type V Collagen-Induced Oral Tolerance Plus Low Dose Cyclosporine Prevents Rejection of MHC Class I and II Incompatible Lung Allografts. Journal of Immunology. Author manuscript; available in PMC 2010 December 7. Published in final edited form as: J Immunol. 2009 July 1; 183(1):237-245. PMCID:PMC2997997.

R72. Wilkes, D.S. A Breath of Fresh Air for Lung Transplant Recipients. Science

Translational Medicine. 2009 Oct 28; 1(4):4ps5. PMID: R73. Wilkes, D.S. Primary Graft Dysfunction: It’s all the RAGE. American Journal of

Respiratory and Critical Care Medicine. 2009 Nov 15; 180(10):915-916. PMID:19897768

R74. Dart, M.L., E. Jankowska-Gan, D.A. Roenneburg, G. Huang, M.R. Keller, J.R.

Torrealba, A. Rhoads, S. Marshall-Case, D.S. Wilkes, W.J. Burlingham, D.S. Greenspan. IL-17-dependent Autoimmunity to Collagen Type V in Atherosclerosis. Circ Res. Author manuscript; available in PMC 2011 October 29. Published in final edited form as: Circ Res. 2010 October 29; 107(9):1106-1116. PMC3010213.

R75. Wilkes, D. S. Airway Hypoxia, Bronchiolar Artery Revascularization, and OB/BOS:

Are We There Yet? Amer. J. Resp. Crit. Care Med. 2010 Jul 15; 182(2):136-137. PMID:20634500

R76. Gibau, G.S.; Foertsch, J., Blum, J.S., Brutkiewicz, R., Queener, S. Roman, A., Rhodes,

S. Sturek, M.,; Wilkes, D.S., Broxmeyer, H. Diversifying Biomedical Training: A Synergistic Intervention. Journal of Women and Minorities in Science and Engineering. Author manuscript; available in PMC 2011 July 25. Published in final edited form as; J Women Minor Sci Eng. 2010;. v16.i3.20. PMCID:PMC3143029.

R77. Fighali-Bostwick,C., D.S. Wilkes. Autoimmunity in IPF: Are Circulating

Autoantibodies Pathogenic or Epiphenomena? American Journal of Respiratory and Critical Care Medicine. 2011. 183:692-3. PMID:21471064

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R78. Shekhar, A., S. Denne, W. Tierney, D.S. Wilkes, D.C. Brater. Indiana CTSI: A Model for Engaging Public-Private Partnerships. Clinical Translational Science. 2011. 4:80-83. PMID:21463491

R79. Shilling, R.A., D.S. Wilkes. Role of Th17 Cells and IL17 in Organ Transplant

Rejection. Invited Review. Seminars in Immunopathology. 2011 Mar; 33(2):129-134. PMID:21279808

R80. Fan, L., H.L. Benson, R. Vittal, E. A. Mickler, R. Presson, A.J. Fisher, O.W.

Cummings, K.M. Heidler, M.R. Keller, W.J. Burlingham, D.S. Wilkes. Neutralizing IL-17 Prevents Obliterative Bronchiolitis in Murine Orthotopic Lung Transplantation. American J. Transplantation Author manuscript; available in PMC 2012 May 1. Published in final edited form as: Am J Transplant.2011 May; 11(5):911-922.

R81. Wilkes, D.S. Chronic Lung Allograft Rejection and Airway Microvasculature:

Is HIF-1 the Missing Link? Journal of Clinical Investigation. 2011 June 1; 121(6):2155-2157. PMCID:PMC3104786.

R82. Benson, H.L., S. Mobashery, M. Chang, F. Kheradmand, J.S. Hong, G.N. Smith, R.

Shilling, D.S. Wilkes. Endogenous MMP2 and MMP9 Regulate the Activation of CD4+ and CD8+ T Cells. 2011. American Journal of Respiratory Cell and Molecular Biology. 2011. 44:700-708. PMCID:PMC3095987.

R83. Diamond, J.M., D. J. Lederer., S.M. Kawut, J. Lee, V. N. Ahya, S.B., S.M. Palmer,

V.N. Lama, S. Bhorade, M. Crespo, E. Demissie, J. Sonett, K. Wille, J. Orens, A. Weinacker, D. Weill, B. A. Kohl, C.C. Deutschman, S. Arcasoy, A.S. Shah, P.D. Shah, J. A. Belperio, D. Wilkes, J.M. Reynolds, L.B. Ware, J.D. Christie; Lung Transplant Outcomes Group. Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis. Am J Transplant. 2011. 11:2517-22. PMID:21883907

R84. Benson, H.L., D.S. Wilkes. Matrix metalloproteinases in T cell mediated pulmonary

diseases. Front Biosci (Elite Ed). 2012. 4:2162-9. PMID:22202028 R85. Wilkes, D.S. Autoantibody Formation in Human and Rat Studies of Chronic Rejection

and Primary Graft Dysfunction. Seminars in Immunology. 2012. 24(2):131-5. PMID:21925897

R86. Benson, H.L., H. Suzuki, J. Lott, A.J. Fisher, C. Walline, K.M. Heidler, R. Brutkiewicz,

J.S. Blum, D.S. Wilkes. Donor Lung Derived Myeloid and Plasmacytoid Dendritic Cells Differentially Regulate T Cell Proliferation and Cytokine Production. Respiratory Research. 2012; 13(1):25. PMCID:PMC3352265.

R87. Suzuki, H., L. Fan, D.S. Wilkes. Orthotopic Transplantation in Mice. Journal of

Visualized Experiments (JoVE). 2012.10.pii:3947.doi:10.3791/3947. PMID:22805894

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R88. Shah RJ, Bellamy SL, Localio AR, Wickersham N, Diamond JM, Weinacker A, Lama VN, Bhorade S, Belperio JA, Crespo M, Demissie EJ, Kawut SM, Wille KM, Lederer DJ, Lee JC, Palmer SM, Orens J, Reynolds J, Shah A, Wilkes D.S., Ware LB, Christie JD. A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation. Journal of Heart and Lung Transplantation. 2012. 31:942-9. PMID:22694851

R89. Diamond JM, Meyer NJ, Feng R, Rushefski M, Lederer DJ, Kawut SM, Lee JC, Cantu

E, Shah R, Lama VN, Bhorade S, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Weinacker A, Weill D, Arcasoy S, Shah PD, Belperio JA, Wilkes D, Ware LB, Palmer SM and Christie JD for the Lung Transplant Outcomes Group.Variation in PTX3 is Associated With Primary Graft Dysfunction After Lung Transplantation. American Journal of Respiratory and Critical Care Medicine. 2012. 186:546-552. PMID: 22822025

R90. Khalil J Diab, K., Z. Yu, J.A. Shmalo, M.G. Lykens, K.L. Wood, F.D. Sheski, D.S.

Wilkes, M.O. Farber, R.P. Nelson, Jr. Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Transplantation. Biology of Blood and Bone Marrow Transplantation. 2012. 18:1827-34. PMID:22766224

R91. LEAD AUTHORS: Raghu G, Anstrom KJ, King TE Jr, Lasky JA, Martinez FJ.

COLLABORATORS: Martinez FJ, Raghu G, Schwarz M, Toews GB, Hunninghake G, Zibrak J, Demersky A, Vey M, Rosas IO, Debrosse P, Culver DA, Chapman J, Olman M, Lubell S, Wehrmann R, Morrison LD, Steele MP, Haram T, Kidd R, Kallay M, Lyda E, Ryu JH, Utz JP, Limper AH, Daniels CE, Meiras K, Walsh S, Sahn S, O'Banner N, Stokes F, Brown KK, Bair C, Kervitsky D, Ettinger NA, Merli S, Criner G, Swift IQ, Satti A, Cordova F, Patel N, West K, Jones G, Lasky JA, Ditta S, de Andrade J, Thannickal VJ, Stewart M, Belperio J, Lynch JP 3rd, Calahan E, Lopez P, King TE Jr, Collard HR, Golden J, Wolters P, Eller A, Noth I, Hogarth DK, Sandbo N, Strek ME, Maleckar S, Rahimova G, Sardin L, Roman J, Perez R, Perez T, Glassberg MK, Simonet E, Martinez FJ, Baumann K, Chan K, Chughtai A, Gross B, Flaherty KR, Han ML, Hyzy R, Kazerooni E, Moore B, Myers J, Toews GB, White E, Dahlgren D, Rossman M, Kreider M, Le K, Fitzgerald J, Glazer C, Scholand MB, Brewster L, Johnson A, Raghu G, Berry-Bell P, Snydsman A, Loyd JE, Lancaster L, Lawson W, Greer R, Kinser K, Richardson R, Mason W, Kaner RJ, Bandong K, Antin-Ozerkis D, Holm C, Estrom J, Lynch DA, Colby T, Anstrom KJ, Eisenstein EL, Sundy JS, Davidson-Ray L, Dignacco P, Edwards R, Anderson R, Beci R, Calvert S, Gentry-Bumpass T, Hill D, Hwang K, Kaur J, Matti C, Meredith A, Pesarchick J, Ramey S, Roberts RS, Sharlow A, Winsor J, Yang Q, Yow E, Weinmann GG, Reynolds H, Schmetter B, Tian X, Kiley J, Davis G, Levine R, Nathan SD, Rounds S, Thompson BT, Thompson B, Bitterman PB, Franks TJ, Idell S, Piantadosi S, Rom WN, Selman M, Wilkes DS. Prednisone, Azathioprine, and N-acetylcysteine for Pulmonary Fibrosis. N Engl J Med. 2012. 66:1968-77. PMID: 22607134

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R92. Weiguo Y., W. Y. Zhang, R. Jabeen, E. Nguyen, D.S. Wilkes, R.S. Tepper, M.H. Kaplan, B. Zhou. IL-9 is Required for TSLP-mediated Allergic Airway Inflammation. Immunity. 2013. 38:1–13. PMID:23376058

R93. Emitiazjoo, A.M., D. S. Wilkes. Humoral Immunity and Development of Obliterative

Bronchiolitis Post Lung Transplantation – is there a Link? American Journal of Respiratory Cell and Molecular Biology. 2013. 48:145–149. PMID:23087052

R94. Diamond, J.M., M.K. Porteous, E. Cantu, N. J Meyer, R. J. Shah; D. J. Lederer, S.M.

Kawut; J.C Lee, S. Bellamy, S.M. Palmer, V. N. Lama, S. Bhorade, M. Crespo, E. Demissie, K. Will.; J. Orens; P.D. Shah, A. Weinacker, D. Weill, S. Arcasoy, D.S. Wilkes, L.B. Ware, J.D. Christie. Elevated Plasma Angiopoietin-2-levels and Primary Graft Dysfunction after Lung Transplantation. PlosOne. 2013. 7(12): e51932. doi:10.1371/journal.pone.0051932.

R95. Lott, J.M., S. Sehra, P. Mehrotra, E.A. Mickler, A.J. Fisher, R.G. Presson, M.F. Busk,

S. Goenka, S.E. Wenzel, M.H. Kaplan, D.S. Wilkes. Type V Collagen-Induced Tolerance Prevents Airway Hyper-responsiveness. American Journal of Respiratory Cell and Critical Care Medicine. 2013. 187:545-457. PMID:23418334

R96. Weber, D.J., D.S. Wilkes. Role of Autoimmunity in Obliterative Bronchiolitis Post

Lung Transplantation. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2013. 304:L307-11. PMID:23262227

R97. Vittal, R., L. Fan, H.L. Benson, E. Mickler, C. Zhang, O.W. Cummings, D.S. Wilkes.

IL-17-Mediated Collagen V Expression and EMT is dependent on TGF-β-mediated p38MAPK and FAK pathways. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2013.304:L401-14. PMID 23262228

R98. Joshua, D., L. James, S. Kawut, R. Shah, A. Russell, D. Lederer, E. Cantu,B. Kohl, V.

Lama, S. Bhorade, M. Crespo, E. Demissie, J. Sonett, K. Wille, J. Orens, A. Shah, A. Weinacker, S. Arcasoy, P. Shah, D.S. Wilkes, L. Ware, S. Palmer, J. Christie. Clinical Risk Factors for Primary Graft Dysfunction after Lung Transplantation. American Journal of Respiratory Cell and Critical Care Medicine. 2013. 187:527-34. PMID:23306540

R99 Shah, R.J., J.M. Diamond, E. Cantu, J.C. Lee, D.J. Lederer, V.N. Lama, J. Orens, A.

Weinacker, D.S. Wilkes, S. Bhorade, K.M. Wille, L.B. Ware, S.M. Palmer, M. Crespo, A.R. Localio, E.J. Demissie, S.M. Kawut, M.S., S.L. Bellamy, J.D. Christie.

Latent class analysis identifies distinct phenotypes of primary graft dysfunction after lung transplantation. Chest. 44:616-22. PMID:23429890

R100. Vittal, R., A. Fisher, H. Gu, E.A. Mickler, A. Panitch, C. Lander, O.W. Cummings,

D.S. Wilkes. MAPKAPK2 Inhibition with MMI-0100 Protects Against Established Bleomycin-Induced Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology. 2013. 49:47-57. PMID:23470623

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R101. Kyra A. Oswald-Richter, K.A., B.W. Richmond, N.A. Braun, J. Isom, S. Abraham,

T.R. Taylor, J.M. Drake, D.A. Culver, D.S. Wilkes, W.P. Drake. Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosis. Journal of Immunology. 2013. 190:5446-53.

R102. Walline, C., S. Sehra, A. Fisher, L. Guindon, I. Kratzke, J. Montgomery, N.L. Glosson,

H.L. Benson, D.S. Wilkes, R.R. Brutkiewicz, M.H. Kaplan, J.S. Blum. Allergic airway disease enhances inflammation during acute pulmonary vaccinia virus infection. Plos One. 2013.19;8:e62222.

R103. Suzuki, H., M.E. Lasbury, L. Fan, R. Vittal, E.A. Mickler, H.L. Benson, R. Shilling, Q.

Wu, D.J. Weber, S.R. Wagner, M. Lasaro, D. Devore, Y. Wang, G.E. Sandusky, K. Lipking, P. Pandya, J. Reynolds, R. Love, T. Wozniak,, H. Gu, K.M. Brown, D.S. Wilkes. Role of Complement Activation in Obliterative Bronchiolitis Post Lung Transplantation. Journal of Immunology. In Press.

R104. Vittal, R., E.A. Mickler, A.J. Fisher, C. Zhang, K. Roththar, H. Gu, K.M. Brown, A. Emtiazdjoo, J.M. Lott, S. Frye, G.N. Smith, O.W. Cummings, D.S. Wilkes. Type V Collagen Suppressed Collagen Deposition, TGF-β and Related Transcripts in Pulmonary Fibrosis. PlosOne. In Press.

R105. Shah RJ, N. Wickersham, D.J. Lederer, S.M. Palmer, E. Cantu, J.M. Diamond, S.M. Kawut, V.N. Lama, S. Bhorade, M. Crespo, E. Demissie, J. Sonett, K. Wille, J. Orens, A. Weinacker, P. Shah, S. Arcasoy, D.S. Wilkes, J.D. Christie, L.B. Ware, Pre-operative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation. American Journal of Transplantation. In Press.

R106. Weber, D.J., Y.M. Allette, D.S. Wilkes, F.A. White. The HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury Induced Pulmonary Dysfunction. Submitted.

R107. Pandya, P., D.S. Wilkes. The Complement System and Lung Disease. Submitted.

R108. Emtiazjoo, A.M., R. J. Shah, J.M. Diamond, P.A. Smith, D.W. Roe, K.M. Wille, J.B. Orens, L.B. Ware, A. Weinacker, V.N. Lama, S.M. Bhorade, S.M. Palmer, M. Crespo,

D.J. Lederer, E. Cantu, G.J. Eckert, J.D. Christie, D.S. Wilkes. Plasma Complement C5a is Associated with Primary Graft Dysfunction and Mortality after Lung Transplantation. Submitted.

R109. Shah, R.J., J.M. Diamond, V. Ahya, S.M. Arcasoy, J.A. Belperio, S. Bhorade, E. Cantu,

M. Crespo, C. Deutschman, E.J. Demissie, S.M. Kawu, B. Kohl, V. Lama, D.J. Lederer, J.C. Lee, J.B. Orens, S.M. Palmer, J. Reynolds, A. Shah, P. Shah, J. Sonett, K.M. Wille, A. Weinacker, D.S. Wilkes, D. Weill, J.D. Christie, L.B. Ware. Elevated Plasma Monocyte Chemotactic Protein-1 (MCP-1) Levels Are Associated With Primary Graft Dysfunction Following Lung Transplantation. Submitted.

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R110. Goss, K., T. Lahm,O. Ahmad, I. Gradus-Pizlo, D.S. Wilkes, M. Duncan, D. Roe. Inhaled Prostacyclin As A Bridge To Lung Transplant In Patients With Severe Parenchymal Lung Disease And Pulmonary Hypertension: A Case Series. Submitted.

R111. Shah, RJ, JM Diamond, E Cantu, J Flesch, JC Lee, DJ Lederer, VN Lama, J Orens, A

Weinacker, DS Wilkes, D Roe, S Bhorade, KM Wille, LB Ware, SM Palmer, M Crespo, EJ Demissie, J Sonnet, A Shah, SM Kawut, SL Bellamy, AR Localio, JD Christie. Use of a simple prediction model improves pre-transplant risk stratification for primary graft dysfunction after lung transplantation. Submitted.

R112. Wu, Q., H. Suzuki, P. Gupta, S. Wagner, L. Fan, D.S. Wilkes, R.A. Shilling. Th17 cells

Are Not Required For Cellular Rejection And Fibrosis In A Mouse Model Of Orthotopic Lung Transplant. Submitted.

Research - Book Chapters/Case Reports R1. Wilkes D.S. Cytokines in the lung. Chest. 1994.106:30. R2. Lipscomb M.F., D.E. Bice, C.R. Lyons, M.R. Schulyer, and D.S. Wilkes. Models for

Lung Transplantation and Graft Versus Host Disease. In: The regulation of pulmonary immunity. Adv. Immunol. 1995. 59:369-455.

R3. Weissler J.C. and D.S. Wilkes. Role of dendritic cells and alveolar macrophages in

regulating pulmonary B cell function. In: Lung Macrophages and Dendritic Cells. Publisher: Marcel-Dekker. 1997. 102:335-372.

R4. Terry, T.G. and D.S. Wilkes. Paradoxical Pulmonary Embolism: A case of mistaken

identity. J. Crit. Illness. 1999. 14:384-386. R5. Roe, D. and D. S. Wilkes. Role of Bronchoscopy in Management of Lung Transplant

Patients. Invited Review. Proceedings of the Japanese Society of Bronchology. 2002. R6. Knox, K., and D.S. Wilkes. Diagnosis and Treating the Sarcoidosis Puzzle.

Physicians Practice. 2003. 13: A1-A5. R7. Roberts, S., D.S. Wilkes, R. Burgett, K.S. Knox. A Case of Refractory Ocular and

Cardiac Sarcoid Responding to Infliximab. Chest. 2003. 124:2028-31. R8. Swanson, K., D.S. Wilkes. Dendritic Cells in Transplantation: Origin, Immune

Activation, and Allograft Tolerance. In: Immunobiology of Organ Transplantation. D.S. Wilkes and W. Burlingham, Editors. Kluwer/Plenum Publishing Corporation. 2004.

R9. Roberts, S.D., G.W. Mirowski, D.S. Wilkes, S.D. Teague, K.S. Knox. Sarcoidosis part

I: pulmonary manifestations. J Am Acad Dermatol. 2004. 51:448-51.

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R10. Roberts, S.D., G.W. Mirowski, D.S. Wilkes, P. Kwo, K.S. Knox. Sarcoidosis part

II: extrapulmonary and systemic manifestations. J Am Acad Dermatol. J Am Acad Dermatol. 2004. 51:628-30.

R11. Olafsson, E.J., Zeni, T.; D.S. Wilkes. Forty six year old male with excruciating

shoulder pain. Chest. 2005. 127:1039-44. R12. Snyder, M.J., M.R. Jacobs, R.G. Grau, D.S. Wilkes, K. S. Knox. Resolution of Severe

Digital Ulceration during a Course of Bosentan Therapy. Annals of Internal Medicine. 2005.142:802-803

R13. Erickson, B.W., L.C. Cripe, K. Rieger, O.W. Cummings, D.S. Wilkes. A 64 Year Old

Woman with Papular Facial Lesions and Bilateral Pulmonary Nodules. Respiration. 2007;74:471-474.

R14. Shilling, R.A., D.S. Wilkes. “Immunology of Lung Transplantation” in “Lung

Transplantation”, Editors: Wickii Vigneswaran and Edward Garrity. Informa Healthcare Publishers. 2010.

Textbooks 1. Wilkes, D.S. and W. Burlingham, Editors. Immunobiology of Organ

Transplantation. Kluwer/Plenum Publishing Corporation. 2004. Video 1. Videotape – NIH T35 Summer Research Program, 2000. D. S. Wilkes – Executive

Producer.