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CV - R.A. Manji MD PhD MBA 1 Curriculum Vitae Rizwan A. Manji MD, PhD, FRCSC, MBA Contact Information: Cardiac Sciences Program Asper Clinical Research Institute St. Boniface General Hospital CR3014 369 Tache Avenue Winnipeg, Manitoba, R2H 2A6 Office: (204) 258-1031 Fax: (204) 231-4624 Pager: (204) 935-2564 E-mail:[email protected]

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Page 1: Curriculum Vitae Rizwan A. Manji MD, PhD, FRCSC, MBA...2017 Dollars and Sense — Physician Leadership Institute, Winnipeg, Manitoba – Apr. 10 – May 21, 2017 2017 Crucial Conversations

CV - R.A. Manji MD PhD MBA 1

Curriculum Vitae

Rizwan A. Manji

MD, PhD, FRCSC, MBA

Contact Information:

Cardiac Sciences Program Asper Clinical Research Institute St. Boniface General Hospital CR3014 — 369 Tache Avenue Winnipeg, Manitoba, R2H 2A6 Office: (204) 258-1031 Fax: (204) 231-4624 Pager: (204) 935-2564 E-mail:[email protected]

Page 2: Curriculum Vitae Rizwan A. Manji MD, PhD, FRCSC, MBA...2017 Dollars and Sense — Physician Leadership Institute, Winnipeg, Manitoba – Apr. 10 – May 21, 2017 2017 Crucial Conversations

CV - R.A. Manji MD PhD MBA 2

Current Appointments Associate Professor — Department of Surgery and Anesthesiology — University of Manitoba Cardiac Surgeon/Intensivist — Cardiac Sciences Program — WRHA/St. Boniface Hospital

Clinical Experience 2007-Present Intensivist — Winnipeg Regional Health Authority, Winnipeg, Manitoba — Cardiac Surgery and General Systems 2005-2007 House Medical Officer — Critical Care Medicine, Grace and Concordia Hospitals Winnipeg Regional Health Authority, Winnipeg, Manitoba 1999-2005 Advanced Cardiac Life Support Medical Director and Instructor — Grant MacEwan Community College, Edmonton, Alberta 1998-2005 Basic Trauma Life Support Medical Director and Instructor — Grant MacEwan Community College, Edmonton, Alberta 1998-2005 Advanced Trauma Life Support Instructor — Royal Alexandra Hospital, Edmonton, Alberta

Academic Endeavours

Final Degree: MBA Date Completed: February, 2008 Specialty: Master of Business Administration Institution/City/Country: University of Manitoba, Winnipeg, Manitoba, Canada Final Degree: FRCPC Date Completed: September, 2007 Specialty: Critical Care Medicine Institution/City/Country: University of Manitoba, Winnipeg, Manitoba, Canada Final Degree: FRCSC Date Completed: June 2005 Specialty: Cardiac Surgery Institution/City/Country: University of Alberta, Edmonton, Alberta, Canada Final Degree: PhD Date Completed: July 2001 Specialty: Experimental Surgery Institution/City/Country: University of Alberta, Edmonton, Alberta, Canada

Page 3: Curriculum Vitae Rizwan A. Manji MD, PhD, FRCSC, MBA...2017 Dollars and Sense — Physician Leadership Institute, Winnipeg, Manitoba – Apr. 10 – May 21, 2017 2017 Crucial Conversations

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i. Undergraduate 1995 MD, Doctor of Medicine with Distinction and Honours in Research — University of Alberta, Edmonton 1993 BMSc, Bachelor of Medical Science with Distinction — University of Alberta, Edmonton ii. Graduate and Post-doctoral: 2007-2008 MBA, Master of Business Administration — University of Manitoba, Winnipeg 2005-2007 Fellow Critical Care Medicine — University of Manitoba, Winnipeg 2004-2005 Chief Resident, Cardiac Surgery — University of Alberta, Edmonton 2001-2005 Resident in Cardiac Surgery — University of Alberta, Edmonton 1997-2001 PhD, Doctor of Philosophy in Experimental Surgery — University of Alberta, Edmonton 1995-1997 Resident, General Surgery— University of Alberta, Edmonton iii. Licensure, certification, and boards 2007 FRCPC, Fellow of the Royal College of Physicians of Canada — Critical Care Medicine 2005 FRCSC, Fellow of the Royal College of Surgeons of Canada — Cardiac Surgery 1997 Licentiate Medical Council of Canada 1996 USMLE - Part I and Part II 1998 Advanced Cardiac Life Support Instructor 1998 Advanced Trauma Life Support Instructor 1998 Basic Trauma Life Support Instructor 1995 Pediatric Advanced Life Support iv. Continuing Medical Education 2018 Influencer - Centre for Healthcare Innovation, Winnipeg, Manitoba – Oct 19-20,

2018 2017 Dollars and Sense — Physician Leadership Institute, Winnipeg, Manitoba – Apr.

10 – May 21, 2017 2017 Crucial Conversations - Centre for Healthcare Innovation, Winnipeg, Manitoba - Jun. 1-2, 2017 2017 Echo Guided Life Support Ultrasound in Shock Course – University of Manitoba, Winnipeg, Manitoba - Sept 20, 2017 2016 Self Awareness and Effective Leadership — Physician Learning Institute, Winnipeg, Manitoba — Nov. 3-4, 2016 2016 Conflict Management and Negotiation — Physician Learning Institute, Winnipeg, Manitoba — Nov. 26-27, 2016 2016 Team STEPPS training 2015 CALS, Cardiac Surgery Advanced Life Support

Page 4: Curriculum Vitae Rizwan A. Manji MD, PhD, FRCSC, MBA...2017 Dollars and Sense — Physician Leadership Institute, Winnipeg, Manitoba – Apr. 10 – May 21, 2017 2017 Crucial Conversations

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Awards and Distinctions 2016 Feature on CTV Morning News Winnipeg – Cardiac Surgery in Low Middle Income Countries – for May 25, 2016 - http://winnipeg.ctvnews.ca/mobile/video? clipId=877087 2016 Featured scientist in Research Was Here – Winnipeg Free Press Newspaper – Mar 12, 2016, Sept 10, 2016, Sept 24, 2016, Oct 22, 2016 2016 Featured Scientist, La Recherché au Rendez-Vous, La Liberté Newspaper,

Nov. 15, 2016 2011 Citation Finalist — Society of Critical Care Medicine Annual Meeting — Abstract: What is the usefulness of 4T test and Enzyme Linked Immunosorbent Assay in Decision Making in Post Cardiac Surgical ICU Patients Suspected of Heparin Induced Thrombocytopenia? 2006 Archer Daniels Midland Fellowship, I.H. Asper School of Business, University of Manitoba 2005 Postgraduate Medical Publication Research Prize, University of Alberta — Manuscript: Glutaraldehyde—Fixed Bioprosthetic Heart Valve Conduits Calcify and Fail from Xenograft Rejection 2005 New Era Cardiac Care Scholarship to attend and present at Innovation & Technology Meeting 2005 First Place Critical Care Medicine In-training Exam, University of Manitoba 2005 Cardiac Surgery First Prize — 97th percentile rank in Cardiac Surgery in American Association of Thoracic Surgery Exam, University of Alberta 2004 Cardiac Surgery First Prize — 93rd percentile rank in Cardiac Surgery in the American Association of Thoracic Surgery Exam, University of Alberta 2003 Cardiac Surgery First Prize — 96th percentile rank in Cardiac Surgery in the American Association of Thoracic Surgery Exam, University of Alberta 2002 U. of A. Medical Staff Society Resident Publication Prize — Manuscript: Human ABO Blood Group is Important in Survival and Function of Porcine Working Hearts 2002 George Graham Bursary for Excellence in Resident Research, University of Alberta 2002 CIHR Resident Publication Prize — Manuscript: Human ABO blood Group is Important in Survival and Function of Porcine Working Hearts, University of Alberta 2001 Featured in the Edmonton Sun Newspaper on January 14, 2001 and November 4, 2001: Cardiac xenotransplantation to address the donor organ shortage. 2001 Finalist in Student Award Competition Canadian Cardiovascular Congress Meeting. Abstract: Critical Factors in Survival of a Pig-Human Xenograft 2001 Nominated for NSERC Doctoral Research Award, Dept. of Surgery University of Alberta 2001 Best Abstract Award (Student) — 6th Symposium of World Artificial Organ, Immunology, and Transplantation Society

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2000 Winner General Surgery Resident Research Day — Abstract: Testing the Efficacy of Specific Anti-α-Gal Antibody Depletion at Prolonging Survival of an Ex-vivo Porcine Working Heart in Porcine-Human Cardiac Xenotransplantation

1995 Mosby Book Award — Excellent Academic Standing in Medical School Class, University of Alberta 1995 First Prize in Dermatology, University of Alberta 1994 Accepted into Alpha Omega Alpha Honour Medical Society 1991-1994 Aga Khan Foundation Canada Scholarship for Academic Excellence, University of Alberta 1993 Nat Christie Foundation Scholarship for Academic Excellence, University of Alberta 1992 Winner Student Research Day, Faculty of Medicine, University of Alberta 1993 Dr. Allan Coates Rankin Prize in Medical Microbiology and Infectious Diseases, University of Alberta 1992 Louise McKinney Post-Secondary Scholarship, University of Alberta 1990 Prime Evils Athletic Association Scholarship

Academic Appointments 2017 Associate Professor — Department of Anesthesiology, University of Manitoba 2017 Associate Professor — Department of Surgery, University of Manitoba 2012 Assistant Professor — Department of Anesthesiology, University of Manitoba 2007 Assistant Professor — Department of Surgery, University of Manitoba 2007 Cardiac Surgeon/Intensivist — Cardiac Sciences Program, SBGH, Winnipeg

Administrative/Service Administrative/Committees/Service 2019-present Grant Reviewer – Health Sciences Foundation – Winnipeg, Manitoba 2019-present Physician representative – St. Boniface Patient Safety and Quality Committee 2019-present Member – Canadian Critical Care Society Ethics Committee 2018-present Member – Professional Advisory Council– St. Boniface Hospital, Winnipeg, Manitoba 2018 Vice- Chair – Physician Wellness Committee – Doctors Manitoba – Winnipeg,

Manitoba 2018- present Member at Large – Department of Surgery GFT Executive – University of

Manitoba 2018- present Cardiac Surgery Residents CanMEDS Director – University of Manitoba 2018- present Cardiac Sciences Program Revascularization Committee – University of

Manitoba 2018- present Cardiac Sciences Program Scholarship Committee – University of Manitoba 2018 Interviewer— Multiple Mini Interview (medical school entrance interviews) — University of Manitoba — Feb. 2018 2017-present Member - Global Surgery — Department of Surgery – University of Manitoba

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2017-present Rater for McMaster Online Rating of Evidence 2017-present Cardiac Surgery Finance Committee Chair 2017-present Physician Health and Wellness Committee – Doctors Manitoba, Winnipeg, MB 2017-present Editorial Board member — CV Network (official bulletin of the International Academy of Cardiovascular Sciences 2017-present Secretary/ Treasurer – St. Boniface Hospital Medical Advisory Council -- Winnipeg, Manitoba 2017 Interviewer — Medical Student Admissions — MMI interviewer — Feb. 2017 2014-present Medical Advisory Committee — St. Boniface General Hospital, Winnipeg 2014-2017 The Committee on Management and Governance of College of Medicine Departments - University of Manitoba, Winnipeg 2014-2015 ICU Academic Funding Committee — University of Manitoba, Winnipeg 2013-present GFT (geographic full-time) Liaison Committee, University of Manitoba, Winnipeg 2013-present Physician Lead for Canadian Society of Cardiac Surgeons to establish Canadian Cardiac Surgery Contingent to Africa 2012-2014 Deep Venous Thrombosis Protocol Policy Committee — Cardiac Surgery 2012-2015 Canadian Critical Care Society – Member of Finance Committee 2011-present Ventilator Associated Pneumonia Quality Control Committee 2010-present APPROACH Executive Leader 2010-present Treasurer - Canadian Intensive Care Foundation 2010-present Cardiac Surgery Bleed Audits Committee 2009-present Member Board of Directors of the Canadian Intensive Care Foundation 2009-present Member Board of Directors Canadian Humanitarian — Winnipeg Chapter 2009-present Standards Committee for Cardiac Sciences Program — WRHA, St. Boniface General Hospital 2005-2007 Residency Training Committee — Critical Care Medicine 2005-2006 Transition Working Group for Trainees for Canadian Cardiovascular Society Session Chairs/Panel Discussion/ Judging and Reviewing Duties 2019 Reviewer for Scientific Program Advisory Committee for Consortium of Universities for Global Health 2019 Reviewer – Cardiovascular Research 2018 – present Reviewer – Journal of Thoracic and Cardiovascular Surgery 2018 Reviewer – Expert Review of Pharmacoeconomics and Outcomes Research 2018 Reviewer – Annals of Thoracic Surgery 2018 External reviewer for Promotions Committee – Department of Surgery at Western University – London, Ontario 2018 Reviewer for Clinical Interventions in Aging 2018 Reviewer for Scientific Program Advisory Committee for Consortium of Universities for Global Health 2018 Reviewer — American Heart Association Annual Meeting abstracts – for section on Myocardial Protection, Intraoperative Management and Postoperative Critical Care 2018 Reviewer — Canadian Cardiovascular Society meeting abstracts

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2018 Co-Chair — Translink Final (Dissemination) Conference — Possible Solution for Structural Valve Deterioration — Padua, Italy — Jan 23, 2018 2018 Reviewer — 18th International Symposium on Atherosclerosis abstracts 2017-present Reviewer — Journal of Heart and Lung Transplantation 2017 Workshop Author/Moderator — Canadian Cardiovascular Congress— October 22, 2017 — Manji RA, Zeiroth SR, Ross H, MacArthur, Rao V, Singal RK, Bains M, Porepa L, White CW, Frechette L, Arora RC. When is Enough, Enough? — An Ethics Debate 2017 Reviewer — American Heart Association Annual Meeting abstracts – for section on Myocardial Protection, Intraoperative Management and Postoperative Critical Care 2017 Reviewer — Scientific Reports: A Nature Journal 2017 Reviewer — Canadian Cardiovascular Society meeting abstracts

2016 Reviewer – American Heart Association Annual Meeting abstracts – for section on Myocardial Protection, Intraoperative Management and Postoperative Critical Care

2016-present Reviewer — Cost Effectiveness and Resource Allocation journal 2016-present External Grant Reviewer — Physician Services Institute Foundation, Toronto, Ontario

2016-present Reviewer — Canadian Cardiovascular Society Abstracts 2015-present Reviewer — Journal of Heart and Lung Transplantation 2014-present Reviewer — Donalda Huggins Scholarship Award in Anesthesia — Dept of Anesthesia, University of Manitoba 2014 Chair — Canadian Cardiovascular Congress oral session: Information Technology in Cardiac Rehabilitation — The Way of the Future 2014 Reviewer — Journal of Medical Economics 2014 Reviewer — Clinical Medicine Insights: Cardiology 2013- Examiner — International Medical Graduate OSCE 2013- Editorial Board — Journal of Transplantation 2013 Reviewer — Journal Biological Medical Research 2013 Judge — Sanofi BioGENEius Challenge Grade 9-12 Science Fair 2013 Reviewer — Seizure: European Journal of Epilepsy 2012-2013 External Reviewer — National Research Foundation of South Africa 2012-present Examiner — National Assessment Collaboration — Medical Council of Canada for International Medical Graduates 2012-present Reviewer — Canadian Cardiovascular Society Annual Meeting 2011-2012 Judge — CIHR High School Science Fair 2011-present Editorial Board — CV Network 2011 Poster Moderator — Society of Critical Care Medicine Annual Meeting 2010 Reviewer — Society Critical Care Medicine 2009-present Grant Reviewer — Canadian Critical Trials Group/Canadian Intensive Care Foundation 2009 External Reviewer — Circulation (Surg Suppl) 2009 Co-Chair Oral Session — Applied Basic Science II - Canadian Cardiovascular Congress 2009 Reviewer — Canadian Cardiovascular Congress National Meeting

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2008 Sponsor — Stuart Clark Entrepreneurial Business Competition - Asper School of Business, University of Manitoba 2008 Judge — Cardiac Sciences Research Day, University of Manitoba 2008-present Reviewer — Journal American College of Cardiology 2007-present Reviewer — Xenotransplantation 2007 Reviewer — Journal of Cellular and Molecular Medicine 2006-2007 Reviewer — Canadian Cardiovascular Congress 2005-present Reviewer — Circulation 2005 Co-Chair — 6th Annual Cardiovascular Trainee Luncheon, Canadian Cardiovascular Congress, Montreal Quebec 2004 Reviewer — Nephron 2004 External Reviewer — Candidate for promotion of Research Associate Professor of Surgery without tenure, University of Pittsburgh Affiliations/Memberships 2014-present Canadian Cardiovascular Cardiac Critical Care Society (CANCARE) 2011-present Critical Care Anesthesiologists 2011-present Society of Cardiovascular Anesthesiologists 2011-present Society of Thoracic Surgeons 2009-present Canadian Critical Care Trials Group 2007-present Cardiothoracic Surgery Critical Care Association 2007-present Canadian Cardiovascular Society 2007-present Canadian Society of Cardiac Surgeons 2005-present Royal College of Physicians and Surgeons of Canada 2005-present Doctors Manitoba 2005-present Society of Critical Care Medicine 1994-present Alpha Omega Alpha Society 1991-2005 Alberta Medical Association 1998-2005 Immunology Network Group, University of Alberta 1997-2001 Canadian Association of General Surgeons Invited Addresses 2020 Can Evolution and Neuroscience Explain the Epidemic of Medical Error? –

Emergency Medicine Grand Rounds – Winnipeg, Manitoba – January 28, 2020 2019 Can Evolution and Neuroscience Explain the Epidemic of Medical Error? –

Manitoba Association of PeriAnesthesia Nurses meeting – Winnipeg, Manitoba – November 20, 2019

2019 Your Brain, the Tricks It Plays and Medical Error – Department of Pediatrics Grand Rounds – Winnipeg, Manitoba – October 31, 2019

2019 Can Evolution and Neuroscience Explain the Epidemic of Medical Error? – WRHA Quality Improvement and Patient Safety Grand Rounds – Winnipeg, Manitoba – October 28, 2019

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2019 Your Brain, the Tricks It Plays and Medical Error – Grace General Hospital Lunch and Learn Rounds – Winnipeg, Manitoba – March 20, 2019

2019 Your Brain, the Tricks It Plays and Medical Error – Department of Anesthesia Grand Rounds – Winnipeg, Manitoba – March 20, 2019

2019 HITT Diagnosis and Management – STS Critical Care Symposium: Cutting-Edge Strategies for Cardiothoracic Critical Care Emergencies and Evolving Technologies – Jan 27, 2019 – San Diego, California

2019 Your Brain, the Tricks It Plays and Medical Error – Internal Medicine Grand Rounds – Winnipeg, Manitoba – Jan 15, 2019

2019 Your Brain, the Tricks It Plays and Medical Error – Cardiac Anesthesia Rounds – Winnipeg, Manitoba – Jan 9, 2019 2018 Your Brain, the Tricks It Plays and Medical Error – Cardiac Surgery Rounds – Winnipeg, Manitoba – Dec 19, 2018 2018 Your Brain, the Tricks It Plays and Medical Error – ICU Nurses Presentation – Winnipeg, Manitoba – Dec 17, 2018 2018 Your Brain, the Tricks It Plays and Medical Error – ICU Case Presentation

Rounds – Winnipeg, Manitoba – Nov 29, 2018 2018 Your Brain, the Tricks It Plays and Medical Error – WRHA Quality Improvement & Patient Safety Grand Rounds – Winnipeg, Manitoba – Nov 1, 2018 2018 Is Aortic Stenosis an Autoimmune Disease? – ICU Research in Progress Rounds

– October 4, 2018 – Winnipeg, Manitoba 2018 Is Aortic Stenosis an Autoimmune Disease? – Cardiac Anesthesia Grand

Rounds – Sept. 12, 2018 – Winnipeg, Manitoba 2018 ECMO and ARDS: “Is This The Intervention You Are Looking For?” – The 7th

Annual Outcomes Improvement Quality Symposium – Jun. 8, 2018 – Winnipeg, Manitoba

2018 Is Aortic Stenosis an Autoimmune Disease? – Rheumatology Rounds – May 1, 2018 – Winnipeg, Manitoba

2018 Accuracy, Confidence and Medical Error – CanMEDS Health Advocate – Critical Care Medicine – Apr. 11, 2018 – Winnipeg, Manitoba.

2018 Is Aortic Stenosis an Autoimmune Disease? – Cardiac Surgery Grand Rounds – Apr. 4, 2018 – Winnipeg, Manitoba

2018 Opportunities: The Benefits to Helping Those in Need – Department of Surgery Grand Rounds – University of Manitoba Global Surgery – Mar. 21, 2018 – Winnipeg, Manitoba

2018 Animal-derived Heart Valves for the Treatment of Cardiac Patients: State of the Art. EU-funded dissemination conference. Presentation of Manitoba Results — Padua, Italy — Jan. 22, 2018 2018 Bioprosthetic Heart Valve Structural Valve Deterioration: University of Manitoba Phase B2 Patients — Translink FP7 Meeting - Padua, Italy – Jan. 22-25, 2018 2017 Cardiac Surgery in Africa: Update — Canadian Society of Cardiac Surgeons Business Meeting, Montreal, Quebec — Oct. 21, 2017 2017 Canadian Society of Cardiac Surgeons Postgraduate Day – Medical Error, and Cognitive Biases – Canadian Cardiovascular Congress – Oct 2017, Montreal,

Quebec

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2017 Bioprosthetic Heart Valve Structural Valve Deterioration: University of Manitoba Phase B2 Patients — Translink FP7 Meeting - Cremona, Italy – May 17, 2017 2017 Cardiac Surgery in Rwanda — Manitoba Association of Cardiology Technologists

Annual General Meeting - Winnipeg, Manitoba - April 22, 2017 2017 Cardiac Surgery in Rwanda — ICU Case Rounds - University of

Manitoba — April 13, 2017 2016 Bioprosthetic Heart Valve Structural Valve Deterioration: University of Manitoba Phase B2 Patients — Translink FP7 Meeting - London, England, Nov. 10, 2016 2016 Cardiac Surgery in Rwanda — Cardiac Anesthesia Grand Rounds, University of Manitoba — Nov. 2, 2016 2016 Cardiac Surgery in Africa: Update — Canadian Society of Cardiac Surgeons Business Meeting, Montreal, Quebec — Oct. 23, 2016 2016 Cardiac Surgery in Rwanda — Cardiac Sciences Nursing Grand Rounds, University of Manitoba — Oct. 19, 2016 2016 Cardiac Surgery in Rwanda — Cardiac Surgery Grand Rounds, University of Manitoba — Sept. 21, 2016 2016 Seizures Post Cardiac Surgery – Neurology Grand Rounds, University of Manitoba – Feb 12, 2016 2015 Canadian Society of Cardiac Surgeons Post Grad Day, Oct. 25, 2015 - ABC’s of HIT: A Pragmatic Approach to Heparin Induced Thrombocytopenia in Cardiac Surgery 2015 Canadian Society of Cardiac Surgeons Annual General Meeting, Oct. 25, 2015 — Cardiac Surgery in Low and Middle Income Countries 2015 Combined Cardiac Anesthesia and Cardiac Surgery Grand Rounds, Feb. 25, 2015 — Outcomes of Patients with Prolonged Length of Stay in ICU after Cardiac Surgery 2014 Research in Progress, U. of M. Critical Care Medicine, Nov. 13, 2014 — Outcomes of Patients with Prolonged Length of Stay in ICU after Cardiac Surgery 2014 Canadian Society of Cardiac Surgeons Annual General Meeting, Oct. 26, 2014 — Cardiac Surgery and the Developing World: An Update 2014 Canadian Anesthesiologist Society Annual Meeting, Jun. 14, 2014 — Cardiac Surgery in the Developing World: Opportunities for the Cardiac Anesthesiologist 2013 Critical Care Medicine Research In Progress Rounds, Dec. 12, 2013 — Colchicine is the Most Cost Effective Methods to Prevent Post Cardiac Surgery Atrial Fibrillation 2013 Cardiac Anesthesia Rounds, St. Boniface General Hospital Dec. 3, 2013 — Opportunities: Cardiac Surgery in the Developing World 2013 12th Congress for the International Xenotransplantation Association, Osaka, Japan, Nov. 13, 2013 — Xenograft Rejection of Bioprosthetic Heart Valves — Workshop: Strategies for Overcoming Xenograft Loss 2013 Canadian Society of Clinical Perfusion, Montreal, Quebec, Oct. 26, 2013 — Cardiac Surgery in the Developing World 2013 Vascular 2013 Conference, Montreal, Quebec, Oct. 27, 2013 — Opportunities: Cardiac Surgery in the Developing World

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2013 CJOB Radio, The Health Report, Winnipeg, Sept. 29, 2013 — World Heart Day - St. Boniface Hospital Global Heart Initiative 2012 Critical Care Rounds, Royal Jubilee Hospital, Victoria, BC, Aug. 30, 2012 — Heparin Induced Thrombocytopenia 2012 Cardiology Grand Rounds, Winnipeg, Manitoba, Jun 4, 2012 — Heparin Induced Thrombocytopenia 2012 Critical Care Medicine Research in Progress Rounds, Winnipeg, Manitoba, Apr. 5, 2012 — Seizures Post Cardiac Surgery 2012 Cardiac Sciences Program, Winnipeg, Manitoba, Mar. 9, 2012 – Opportunities in the Developing World 2011 Critical Care Nurses Presentation, Winnipeg, MB, Nov. 22, 2011 — Heparin Induced Thrombocytopenia 2011 Department of Anesthesia Grand Rounds, Winnipeg, Manitoba, Sept. 7, 2011 — Heparin Induced Thrombocytopenia 2011 Department of Surgery Research Rounds, Winnipeg, Manitoba, Jan. 14, 2011 — Heparin Induced Thrombocytopenia 2011 Cardiac Surgery Grand Rounds, Winnipeg, Manitoba, Jan. 12, 2011 — Heparin Induced Thrombocytopenia 2010 12th International Congress of Cardiothoracic and Vascular Anesthesia, Beijing, China, Sept. 23, 2010 — Ventricular Arrhythmias: Preoperative Management 2010 Ismail Muslim Congregation, Winnipeg, Manitoba, Jun. 3, 2010 — Diabetes: The Basics 2009 Sharing Best Practices in Cardiac Rehabilitation. Canadian Cardiac Rehabilitation Conference, Edmonton, Alberta, Oct. 25, 2009 — Sharing Best Practices in Cardiac Rehabilitation: Factors affecting referrals to cardiac rehabilitation: WRHA Cardiac Sciences Staff Perceptions 2009 CJOB Radio Health Report, Winnipeg, Manitoba, Mar. 22, 2009 — Heart Valves and Rejection of Bioprosthetic Valves 2009 Critical Care Medicine Grand Rounds, Winnipeg, Manitoba, Feb. 18, 2009 — Patient Safety and Quality Improvement 2009 ICU Nurses Presentation, Winnipeg, Manitoba, Feb. 18, 2009 — Patient Safety and Quality Improvement 2009 Ismaili Muslim Congregation, Winnipeg, Manitoba, Feb. 13, 2009 — Cardiovascular Disease 2008 Ismaili Muslim Congregation, Winnipeg, Manitoba, Jun. 19, 2008 — Cancer Screening 2006 Cardiac Surgery Grand Rounds, Calgary, Alberta, Mar. 31, 2006 — Do Bioprosthetic Valves Reject? 2005 6th Annual Cardiovascular Trainee Luncheon Co-Chair, Canadian Cardiovascular Congress, Montreal Quebec, Oct. 23, 2005 — Databases, Report

Cards, Continuous Quality Improvement Initiatives and Cardiovascular Care in Canada

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Teaching Duties/Experience

Teaching Qualifications 1998 Advanced Cardiac Life Support Instructor 1998 Advanced Trauma Life Support Instructor 1998 Basic Life Support Instructor Student Supervisor Experience Summer Students 2013-present Mr. Young Jung — Pre-Med (Co-supervisor) 2012 Mr. Derek Bueddefeld — Medical Student (primary supervisor) 2012 Mr. Alec Thompson — MSc (Co-supervisor) 2012 Mr. Alex Villafranca — MSc 2012 Mr. Ben Arenson — BSc 2003-2004 Ms. Nimrit Nijar — BSc 2002-2003 Ms. Jennifer Woolsey — BSc 2001-2002 Mr. Akil Gulamhusein— BSc Specialized Course Teaching Duties 2017 Lecturer – Patient Safety and Handovers – Cardiac Surgery Bootcamp – Ottawa, Ontario - July 17-21, 2017 2017 Lecturer – Communication and Conflict – Cardiac Surgery Bootcamp – Ottawa, Ontario - July 17-21, 2017 2017 Lecturer – Practical Approach to Shock in the Cardiac Surgery Patient – Cardiac Surgery Bootcamp – Ottawa, Ontario - July 17-21, 2017 2017-present Lecturer – Critical Care Residents/Fellows and Cardiac Surgery Residents, University of Manitoba - CanMEDS: Communication and Conflict 2017-present Lecturer – Critical Care Residents/Fellows and Cardiac Surgery Residents, University of Manitoba - CanMEDS: Medical Error and Cognitive Biases 2016-present Lecturer — Lines and Tubes in the ICU — Resident teaching 2013-present Lecturer — Critical Care Medicine Clinical Assistant Program, University of Manitoba — Heparin Induced Thrombocytopenia 2013-present Lecturer — Critical Care Medicine Clinical Assistant Program, University of Manitoba — Weaning from Mechanical Ventilation and Neuromuscular Weakness 2012-present Lecturer — Critical Care Residents/Fellows, University of Manitoba — Economic Evaluation of Healthcare Studies 2011-present Lecturer — Critical Care Residents/Fellows, University of Manitoba — Business Management Issues for ICU 2011-present Lecturer — Physician Assistant Lecture Series, University of Manitoba — Wean from Ventilation and Neuromuscular Disease in the ICU

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2010-present Lecturer — Critical Care Residents/Fellows, University of Manitoba — Heparin Induced Thrombocytopenia 2010-present Lecturer — Med 3/4 Surgery Students, University of Manitoba — Cardiac Surgery for the Medical Student 2009-present Lecturer — Cardiac Sciences and Critical Care Residents/Fellows, University of Manitoba — Abstract Writing 2009-present Lecturer — Cardiac Sciences and Critical Care Fellows, University of Manitoba — Patient Safety and Quality Improvement 2007-present Lecturer and Tutorial Instructor — Med 1 Students, University of Manitoba, CV042 — Shock 2007-present Lecturer and Tutorial Instructor — Med 1 Students, University of Manitoba, CV042 — Valvular Heart Disease 2007-present Tutorial Instructor — Med 1 Students, University of Manitoba — Hemodynamics 2007-present Lecturer — ICU Nursing Course, University of Manitoba — Altered Lab Values 2007-present Lecturer — ICU Fellows Lecture Series, University of Manitoba — Applying Business Principles to Health Care 2005-present Resident and Medical Student Teaching and Evaluations, University of Manitoba — ICU procedures, resuscitation 1996-2005 Teacher/Examiner — Surgery Student interns, Year II Medical Students — University of Alberta — Ward teaching, suture skills, surgery OSCE 1998-2005 Instructor/Course Director — Advanced Trauma Life Support, Basic Trauma Life Support and Advanced Cardiac Life Support

Research Experience and Interests

2017-present Immune Response in Aortic Stenosis 2015-present Immune Response to Bioprosthetic Heart Valves — Collaborative study with Translink FP7, Europe 2012-present Outcome studies in Patients with Prolonged ICU Length of Stay after Cardiac Surgery 2012-present Rheumatic Heart Disease in Ethiopia — Prevalence Study and Cost- Effectiveness Study for Prevention of Rheumatic Heart Disease — Collaborative Study with Dr. Julia Witt, Dept. of Health Economics, University of Manitoba and Dr. Richard Northcott, Canadian Humanitarian Organization for International Relief 2011-present Seizures in Cardiac Surgery Patients, University of Manitoba 2011-present Heparin Induced Thrombocytopenia, University of Manitoba 2011-present Gal knockout Transgenic Pig Valves for Bioprosthetic Heart Valve Replacement — Collaborative Study with Dr. D. Cooper, University of Pittsburgh, Dr. Mohiuddin, NIH, and Dr. D. Ayares, Revivicor 2007-present Outcome studies in Cardiac Surgery and Cardiac Surgery Critical Care (rehospitalization, functional survival, staffing models), University of Manitoba

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2006 Cardiac Responsiveness to Dobutamine as Predictor of outcome from Septic Shock in ICU patients, University of Manitoba 2005-2007 Tolerance studies in Xenotransplantation in Infants — Collaborative study with Dr. David Cooper, University of Pittsburgh 2003-2007 Xenoantibodies and Bioprosthetic Cardiac Valve Failure, University of Alberta 1998-2001 Human ABO Blood Group and Anti-α-Gal Antibody Depletion in a Porcine Human Working Heart Model of Hyperacute Rejection — PhD Thesis — University of Alberta

Research Funding Current

Agency/Organization Project Title Amount Date

Cardiac Sciences Program Grant, St. Boniface Hospital

Does Aortic Stenosis Have an Autoimmune Component?

$25,000 2018-present

Dept. Surgery GFT Research Grant, University of Manitoba

Translink FP7 - Immune Response to Bioprosthetic Heart Valves — Site Principal Investigator

$8020 2017 - present

St. Boniface Hospital Foundation Grant

The Immune Response to Aortic Stenosis Valves, Rheumatic Heart Disease Valves and Bioprosthetic Heart Valves — Co-Investigator

$4650 2016-present

Dept. Surgery GFT Research Grant, University of Manitoba

The Immune Response in Aortic Stenosis — Principal Investigator

$15000 2016-present

Dept. of Surgery GFT Research Grant, University of Manitoba

The Cardiac Surgery Patient-Centered Medical Home — A Pilot Study – Co-Investigator

$14997 2015-present

Dept. of Surgery GFT Research Grant, University of Manitoba

The Long term Success of Prolonged Intensive Care after Cardiac Surgery- RESPOND Study – Co-Investigator

$15,000 2014-present

Dept. of Surgery GFT Research Grant, University of Manitoba

Xenograft Rejection of Commercially Used Bioprosthetic Heart Valves — Principal Investigator

$8400 2015-2017

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Dept. of Surgery GFT Research Grant, University of Manitoba

The Prolonged Stay Cardiac Surgery Patient Characterization and Long Term Outcomes — Principal Investigator

$14,875 2013-present

Past

Agency/Organization Project Title Amount Date

Bayer Rivaroxaban for treatment of Patients with Suspected or Confirmed Heparin-Induced Thrombocytopenia — Site Principal Investigator

$1,134,671 2012 - 2014

Anaesthesia Oversight Committee Research Awards

Studies in Heparin Induced Thrombocytopenia – Principle Investigator

$10,000 2010

Manitoba Medical Services Foundation Operating Grant

Stains and Bioprosthetic Heart Valve Inflammation/Calcification — Co-investigator

$35,000 2007

Alberta Heritage Foundation for Medical Research Fellowship

Human ABO Blood Group and anti-α-Gal antibody depletion in Cardiac Xenotransplantation

$30,000/year 1998-2001

Edmonton Civic Employees Research Grant

Human ABO Blood Group and anti-α-Gal antibody depletion in a porcine working heart model — Co-investigator

$10,000/year 1998-2001

Medical Research Council Summer Studentship

Characterizing a new cytokine: P-600 $5000 1992

Alberta Heritage Foundation Summer Studentship

Summer studentship $5000 1991

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Publications and Presentations Thesis 1. ABO Blood Group and Anti-α-Gal Antibody Depletion in a Porcine-Human Working Heart

Xenotransplantation Model of Hyperacute Rejection. Accepted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Experimental Surgery, July 14, 2001, University of Alberta. Examination Committee:, Dr. Arvind Koshal and Dr. Raymond Rajotte (Co-Supervisors), Dr. Gregory Korbutt, Dr. Gary Lopaschuk, and Dr. Allan Murray(Committee Members), Dr. Tom Churchill and Dr. John G. Coles (External Examiners).

Refereed Manuscripts Published 1. Bertie JE, Zhang S, and Manji RA, Infrared intensities of liquids X: Accuracy of current

methods of obtaining optical constants from multiple attenuated total reflection measurements using the circle cell. Applied Spectroscopy 1992; 46:1660.

2. Manji RA and Warnock GL. Left paraduodenal hernia. An unusual case of small bowel obstruction. Can J Surg 2001; 44(6):455.

3. Manji RA, Manji JS, Koshal A, Korbutt GS, and Rajotte RV. Human ABO blood group is important in survival and function of porcine working hearts. Am J Trans 2003; 3:286-93.

4. Manji RA, Rajotte RV, Koshal A. Human O red blood cells and pig-to-human xenotransplantation. Xenotransplantation 2004:11:107.

5. Manji JS, Rajotte RV, Koshal A, Manji RA. Increased apoptosis in porcine cardiac xenografts perfused with human ABO plasma containing the anti-B antibody. Xenotransplantation 2004; 11:378-9.

6. Manji JS, Rajotte RV, Koshal A, Manji RA, Human anti-A and anti-B antibodies interact with anti-α-gal antibody affecting xenograft survival. Xenotransplantation 2004; 11:376-7.

7. Manji RA Zhu LF, Nijjar NK, Rayner DC, Korbutt GS, Churchill TA. Rajotte RV, Koshal A, Ross DB. Glutaraldehyde-fixed Bioprosthetic heart valve conduits calcify and fall from xenograft rejection. Circulation 2006; 114:318-27.

8. Rood PP, Tai H-Chara H, long C, Ezzelarab M, Lin Y-J, van der Windt DJ, Busch J, Ball S, Ayares D, Ijzermans JNM, Wolf RF, Manji RA, Bailey L, Cooper DKC. Late onset of development of anti-nongal antibodies in infant humans and baboons: Implications for xenotransplantation in infants. Transplant International 2007; 20(12):1050.

9. Schaffer SA, Manji RA, Kirkpatrick I, Fang T, Arora RC, Zieroth S, Jassal DS. Negative pressure pulmonary edema in the coronary care unit. Can J Cardiol 2008; Sep. 29(9): e58

10. Manji RA, Wood KE, Kumar A. The history and evolution of circulatory shock. Crit Care Clin 2009 Jan. 25(1):1-29, vii.

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11. Kumar K, Zarychanski R, Bell DD, Manji RA, Zivot J, Menkis AH, Arora RC. The Impact of 24 hour in-house intensivist coverage on a dedicated cardiac surgery ICU. Annals of Thoracic Surgery 2009 Oct 88 (4): 1153 - 61.

12. Freed D, Henzler D, White C, Fowler R, Zarychanski R, Hutchison JS, Arora R, Manji R, Legare J-F, Drews T, Veroukis S, Kesselman M, Guerguerian A-M, Kumar A. Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada. Can J Anaesth. 2010 Mar;57(3):240-7.

13. Manji RA, Kumar A. Determining relevant cortisol concentrations in critically ill patients.Critical Care 2010; 14:113.

14. Manji RA, Menkis AH, Cooper DK. Cardiac xenotransplantation technology provides materials for improved bioprosthetic heart valves. J Thorac Cardiovasc Surg 2011 Jul;142(1):238-9.

15. Manji RA, Grocott HP, Leake J, Ariano RE, Manji JS, Menkis AH, Jacobsohn E. Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. Canadian Journal of Anesthesia: Volume 59, Issue 1 (2012), Page 6-13

16. Manji RA, Menkis AH, Ekser B, Cooper DKC. The future of bioprosthetic heart valves. Indian J Med Res. 2012 Feb; 135(2):150-51

17. Manji RA, Menkis AH, Ekser B, Cooper DKC. Porcine bioprosthetic heart valves: the next generation. Am Heart J. 2012 Aug; 164(2):177-85.

18. Manji RA, Jacobsohn E, Grocott HP, Menkis AH. Longer in-hospital wait times do not result in worse outcomes for patients requiring urgent coronary artery bypass graft surgery. Hosp Prac (1995) 2013; 41(3):15-22.

19. Manji RA, Witt J, Tappia PS, Jung Y, Menkis AH, Ramjiawan B. Cost effectiveness analysis of rheumatic heart disease prevention strategies. Expert Rev. Pharmecoecon Outcomes Res. 2013;13(6):715-24.

20. Manji RA, Menkis AH, Ekser B, Cooper DKC. Bioprosthetic heart valves of the future. Xenotransplantation 2014; 21(1):1-10.

21. Linkins LA, Warkentin TE, Pai M, Shivakumar S, Manji RA, Wells PS, Crowther MA. Design of the rivaroxaban for heparin-induced thrombocytopenia study J .Thromb Thrombolysis 2014;38(4):485-92.

22. Manji RA, Cardiac Surgery in the Developing World. Perfusionist 2014; 24(1): p.31

23. Kumar K, Singal R, Manji RA, Zarychanski R, Bell DD, Freed DH, Arora RC; Cardiovascular Health Research in Manitoba Investigator Group. The benefits of 24/7 in-house intensivist coverage for the prolonged stay cardiac surgery patient. J Thorac Cardiovasc Surg. 2014 Jul;148(1):290-297.

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24. Bednarycyk JM, White CW, Ducas RA, Golian M, Nepomucena R, Hiebert B, Bueddefeld D, Manji RA, Singal RK, Hussain F, Freed DH. Resuscitative extracorporeal membrane oxygenation for in hospital cardiac arrest: A Canadian observational experience. Resusciation 2014;85(12):1713-9.

25. Lee W, Hara H, Cooper DK, Manji RA. Expression of NeuGc on pig heart valves. Xenotransplantation. 2015 Mar-Apr;22(2):153-4. doi: 10.1111/xen.12162. Epub 2015 Mar 6.

26. Manji RA, Grocott HP, Manji JS, Menkis AH, Jacobsohn E. Recurrent seizures following cardiac surgery: risk factors and outcomes in a historical cohort study. J Cardiothorac Vasc Anesth. 2015 Oct;29(5):1206-11. doi: 10.1053/j.jvca.2015.03.020. Epub 2015 Mar 20.

27. Manji RA, Lee W, Cooper DKC. Xenograft Bioprosthetic Heart Valves: Past, Present and Future. Int J Surg. 2015 Nov;23(Pt B):280-4. doi: 10.1016/j.ijsu.2015.07.009. Epub 2015 Jul 17.

28. Manji RA, Hara H, Cooper DK. Characterization of the Cellular Infiltrate in Bioprosthetic Heart Valves Explanted from Patients with Structural Valve Deterioration. Xenotransplantation. 2015 Sep;22(5):406-7. doi: 10.1111/xen.12187. Epub 2015 Aug 27.

29. Manji RA, Arora RC, Singal RK, Hiebert B, Moon MC, Freed DH, Menkis AH. Long Term Outcome and Predictors of Non-Institutionalized Survival after Prolonged ICU Stay Post Cardiac Surgery. Ann Thorac Surg. 2016 Jan;101(1):56-63; discussion 63. doi: 10.1016/j.athoracsur.2015.07.004. Epub 2015 Oct 1.

30. Linkins L, Warkentin TE, Pai M, Shivakumar S, Manji RA, Wells PS, Wu C, Mazi I,Crowther MA. Rivaroxaban for Treatment of Suspected or Confirmed Heparin-Induced Thrombocytopenia Study. J Thromb Haemost. 2016 Apr 8. doi: 10.1111/jth.13330. [Epubahead of print]

31. Lee W, Long C, Ramsoondar J, Ayares D, Cooper DK, Manji RA (co-senior Author), Hara H. Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration? Xenotransplantation. 2016 Aug 11. doi: 10.1111/xen.12254. [Epub ahead of print]

32. Singal RK, Singal D, Bednarczyk J, Lamarche Y, Singh G, Rao V, Kanji HD, Arora RC, Manji RA, Fan E, Nagpal AD. Current and Future Status of Extracorporeal Cardiopulmonary Resuscitation for In-Hospital Cardiac Arrest. Can J Cardiol. 2017 Jan;33(1):51-60. doi: 10.1016/j.cjca.2016.10.024.

33. Manji RA, Arora RC, Singal RK, Hiebert BM, Menkis AH, Early rehospitalization after prolonged intensive care unit stay post cardiac surgery: Outcomes and modifiable risk factors. J Am Heart Assoc 2017 Feb 7; 6(2). pic:e004072. doc 10.1161/JAHA.116.0040702

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34. Arora RC, Manji RA (co-first author), Singal RK, Hiebert B, Menkis AH. Outcomes of Octogenarians Discharged from Hospital after Prolonged Intensive Care Unit Length of Stay after Cardiac Surgery. J Thorac Cardiovasc Surg. 2017 Jul 6. pii: S0022-5223(17)31152-2. doi: 10.1016/j.jtcvs.2017.04.083.

35. Kuo K, Shah P, Hiebert B, Love K, Menkis A, Manji RA, Arora RC. Predictors of survival, functional survival and hospital readmission in octogenarians after surgical aortic valve replacement. J Thorac Cardiovasc Surg. 2017 May 23. pii: S0022-5223(17)31088-7. doi: 10.1016/j.jtcvs.2017.05.047.

36. Magsino K, Sanjanwala R, Hiebert B, Rothney J, Manji R, Arora R, Shah P. Treatment Outcomes for Right-Sided Endocarditis in Intravenous Drug Users: A Systematic Review and Analysis of Outcomes in a Tertiary Centre. Thorac Cardiovasc Surg. 2018 Oct;66(7):552-562. doi: 10.1055/s-0037-1618578. Epub 2018 Jan 19. Review.

37. Yan W, Shah P, Hiebert B, Pozeg Z, Ghorpade N, Singal RK, Manji RA, Arora RC. Long-term non-institutionalized survival and rehospitalization after surgical aortic and mitral valve replacements in a large provincial cardiac surgery centre. Interact Cardiovasc Thorac Surg. 2018 Jul 1;27(1):131-138. doi: 10.1093/icvts/ivy018.

38. Barrie K, Cornick A, Debreuil S, Lee E, Hiebert BM, Manji RA, Bienvenu OJ, McDonald B, Singal RK, Arora RC. Patients with a prolonged intensive care unit length of stay have decreased health-related quality of life after cardiac surgery. Semin Thorac Cardiovasc Surg. 2019 Spring;31(1):21-31. doi: 10.1053/j.semtcvs.2018.07.005. Epub 2018 Aug 16.

39. Arcinas LA, Manji RA, Hrymak C, Dao V, Sheppard JI, Warkentin TE. Autoimmune heparin-induced thrombocytopenia and venous limb gangrene following aortic dissection repair: in vitro and in vivo effects of intravenous immunoglobulin. Transfusion 2019 Mar 23; doi: 10.1111/trf.15263. [Epub ahead of print] [PMID: 30903805]

40. Manji RA, Grocott HP, Arora RC. Medical Error and “Psycho-Physiology”. Seminars in Thoracic and Cardiovascular Surgery Semin Thorac Cardiovasc Surg. 2019 May 14. pii: S1043-0679(19)30148-0. doi: 10.1053/j.semtcvs.2019.05.011. [Epub ahead of print]

41. Manji RA and Arora RC. Commentary: Having the Right “MINDSET”, The Journal of Thoracic and Cardiovascular Surgery 2019, doi: https://doi.org/10.1016/j.jtcvs.2019.04.016. [Epub ahead of print]

42. Manji RA, Arora RC. Commentary: Should Patients Awaiting Cardiac Surgery that Need Anticoagulation be on Direct Oral Anticoagulants or Vitamin K Antagonists? (JTCVS-19-3332 – in press).

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Refereed Monographs/ Book Chapters Published 1. Manji RA, Manji JS, Rajotte RV, Koshal A. Xenotransplantation: An Overview. In

Pathophysiology of Cardiovascular Disease. Edited by N.S. Dhalla, H. Rupp, A. Angel and GN Pierce. Kluwer Academic publishers, Boston 2004:555-575.

2. Tam JW, Manji RAS, Shaikh N, Morris A. Diagnostic approach to endocarditis. In Endocarditis: Diagnosis and Management. Eds.: Chan KL, Embil J, Springe-Verlag, London. 2008: 63-77.

3. Paunovic B, Manji RA, Arora R, Strumpher J, Sigal R, Zivot J, Jacobsohn E. Chapter 17: Sepsis and Vasodilatory Shock in the Cardiac Surgical Patient. In: Sladen RN, ed. Postoperative Cardiac Care. A Society of Cardiovascular Anesthesiologists Monograph.Baltimore: Lippincott Williams & Wilkins, 2011: 335-353.

4. Manji RA and Manji JS. Chapter 15: Studying Xenograft Rejection of Bioprosthetic Heart Valves. In: Xenotransplantation: Methods and Protocols. Editors: Cristina Costa and Rafael Manez 2019 (in press).

Manuscripts Submitted and/or in Revision: 1. Dubiel C, Hiebert BM, Stammers AN, Tanguri N, Singal RK, Manji RA, Rudolph JL, Arora

RC. Delirium definition influences prediction of functional survival in patients one-year post cardiac surgery. Submitted to the Journal of Thoracic and Cardiovascular Surgery.

Refereed Abstracts Published 1. Manji RA, Samaha N, Koshal A, Guenther C. Comparison of continuous arterio-venous

hemodialysis with continuous veno-venous hemodiafiltration in the management of acute renal failure in the cardiovascular surgery intensive care unit. Royal College of Physicians and Surgeons Meeting, Montreal, Quebec. Sept. 1999.

2. Manji RA, Samaha N, Koshal A, Guenther C. The efficacy of continuous veno-venous hemodiafiltration in the management of acute renal failure post-cardiopulmonary bypass in the cardiovascular surgery intensive care unit. 4th International Congress on Continuous Renal Replacement Therapy. San Diego, USA, Mar 1999.

3. Manji RA, Manji JS, Rajotte RV, Afrousian M, Yatscoff R, Koshal A. Specific α-gal antibody removal and human ABO blood group in human-porcine cardiac xenograft survival. Can J Cardiol 2000 Vol 16 Suppl F p.211.

4. Manji R, Manji JS, Koshal A, Afrouzian M, Rajotte RV. Specific α-gal removal improves human-porcine xenograft survival in and ex-vivo porcine working heart model. Clin and Invest Med 2000 Vol 23 (4) p.S6.

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5. Manji RA, Manji JS Rajotte RV, Korbutt GS, Afrouzian M, Koshal A. The importance of α-gal antibody removal and human ABO blood group in human-porcine cardiac xenograft

6. survival. International Society of Cardiothoracic Surgeons – 10th World Congress. Vancouver Canada Aug. 2000.

7. Manji RA, Manji JS, Rajotte RV, Koshal A, Critical factors in survival of a pig-human xenograft. J Mol Cell Cardiol 2001 Vol 33 (6) p.A7.

8. Manji RA, Manji JS, Rajotte RV, Korbutt GS, Koshal A. Critical factors in survival of pig-human xenograft. Can J Cardiol 2001 Vol 17 Suppl C p. 243C.

9. Manji RA, Manji JS, Koshal A, Korbutt GS, Rajotte RV. The ideal human ABO blood group and red blood cells for porcine –to-human cardiac xenotransplantation. Xenotransplantation 2001 Vol 8 Suppl 1 p. 95

10. Manji RA, Manji JS, Rajotte RV, Korbutt GS, Koshal A. Critical factors in survival of a pig-human xenograft. Clin and Invest Med 2001 Vol 24 (4) p. 223.

11. Manji RA, Manji JS, Koshal A, Korbutt GS, Rajotte RV. The ideal human ABO blood groups for porcine-human Xenotransplantation. Am J Trans 2001 Vol 1 Suppl 1 p. 457.

12. Manji RA, Manji JS, Koshal A, Korbutt GS, Rajotte RV. Are there ideal blood groups for porcine-human xenotransplantation? Annual Scientific meeting of Canadian Society of Transplantation, Lake Louise, Alberta, Mar 2001.

13. Manji RA, Manji JS, Rajotte RV, Korbutt GS, Koshal A. Critical factors in survival of a pig-human xenograft. 6th World Artificial Organ, Immunology, and Transplantation Society WAITS Ottawa, Canada. August 2001.

14. Manji JS, Manji RA, Korbutt GS, Rajotte RV, Koshal A. Decreased apoptosis in alpha-gal antibody depleted human plasma perfused porcine working cardiac xenografts. Can J Cardiol 2002 Vol 18 Suppl 8 p.192B.

15. Manji RA, Manji JS, Rajotte RV, Korbutt GS, Koshal A. Human red blood cells in porcine-human cardiac xenotransplantation. Can J Cardiol 2002 Vol 18 Suppl B p.209B

16. Manji JS, Manji RA, Korbutt GS, Rajotte RV, Koshal A. Human ABO blood group antibodies and pig-to-human cardiac xenotransplantation. Can J Cardiol 2002 Vol 18 Suppl B p. 201B.

17. Manji RA, Nijjar N, Woolsey J, Rayner D, Rajotte R, Koshal A, Ross D. Is anti-α-gal antibody involved in the failure of glutaraldehyde fixed bioprosthetic heart valves? Can J Cardiol 2004 Vol 20 Suppl D p. 165D

18. Manji RA, Nijjar NK, Zhu LF, Rayner DC, Korbutt GS, Churchill TA, Rajotte RV, Koshal A, Ross DB. Glutaraldehyde-fixed xenograft bioprosthetic heart valve conduits calcify and fail from xenograft rejection. Can J Cardiol 2005 Vol 21 SupplC p.215C.

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19. Manji RA, Zhu LF, Nijjar NK, Rayner DC, Korbutt GS, Churchill TA, Rajotte RV, Koshal A, Ross DB. Glutaraldehyde-fixed xenograft bioprosthetic heart valve conduits undergo T cell, macrophage and antibody mediated rejection. Can J Cardiol 2005 Vol 21 Suppl C p.214C.

20. Manji RA, Zhu LF, Nijjar NK, Rayner DC, Rajotte RV, Koshal A, Ross DB. Glutaraldehyde-fixed heterograft (bioprosthetic) heart valve conduits fail from rejection mediated by T cells, and macrophages. Exp & Clin Cardiol 2005 Vol 10(1) p. 63.

21. Manji RA, Nijjar N, Zhu LF, Rayner D, Rajotte RV, Koshal A, Ross DB. Glutaraldehyde-fixed bioprosthetic heart valves fail due to xenograft rejection. 25th annual San Diego Cardiothoracic Surgery Symposium. San Diego, California. February 2005.

22. Manji RA, Nijjar N, Zhu LF, Rayner D, Rajotte RV, Koshal A, Ross DB. Glutaraldehyde-fixed bioprosthetic heart valves fail due to xenograft rejection. Annual Meeting of the Society of Cardiothoracic Surgeons of Great Britain and Ireland. London, United Kingdom. March 2005

23. Manji RA, Nijjar N, Zhu LF, Rayner D, Rajotte RV, Koshal A, Ross DB. Glutaraldehyde-fixed bioprosthetic heart valves fail due to xenograft rejection. 8th Annual NewEra Cardiac Care: Innovation & Technology Meeting. Dana Point California. January 2005.

24. Rood PPM, Hara H, Tai H-C, Long C, Ezzelarab M, Lin Y-J, Busch J, Ball S, Ayares D, Wolf R, Manji R, Bailey L, Cooper DKC. Development of anti-pig (anti-gal and anti-nongal) antibodies in infant baboons and humans: implications for xenotransplantation. World Transplant Congress, Boston Massachusetts, July 2006.

25. Kumar K, Durston M, Azordegan N, Bulman C, Moghadasian M, Manji R, Jassal DS, Arora RC. Natural history of bioprosthetic valve failure. Annual American College of Surgeons Manitoba Chapter meeting November 2007.

26. Manji RA, Leslie WD, MacWilliam L, Philipp R, Finlayson GS. Are the data any good? Can J Cardiol 2008 Vol 24 Suppl E P. 258E.

27. Manji RA, Leslie WD, MacWilliam L, Philipp R, Finlayson GS. Does PCI or CABG work long term? Can J. Cardiol 2008 Vol 24 Suppl E p. 309E.

28. Manji RA, Ross DB, Rajotte RV, Koshal A. Do young patients have antibody-mediated rejection of bioprosthetic heart valves? Can J Cardiol 2008 Vol 24 Supple E p. 300E.

29. Kumar K, Zarychanski R, Bell D, Zivot J, Lee J Manji R, Menkis AH, Arora RC. The impact of the Manitoba model of 24 hour in-house intensivists on a dedicated cardiac surgery ICU. Can J Cardiol 2008 Vol 24 Supple E p.113E.

30. Rivet M, Chartrand S, Henry G, Intensive care Cardiac Sciences Nurses, Arora RC, Bell D, Menkis Ah, Zivot J, Manji RA. Bunk beds in the ICU – Can two cardiac surgery patients occupy one ICU bed? Can J Cardiol 2008 Vol 24 Suppl E p. 116E.

31. Kumar K, Staniforth C, Durston M, Manji RA, Jassal DS, Arora RC. Can statin therapy alter the natural history of bioprosthetic valves? Rationale, experimental design, and future implications. 11th Annual NewEra Cardiac Care Conference. January 2008.

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32. Manji RA, Ashan MW, CATSS Database Research Group, Kumar A. In septic shock patients with low cardiac index, initial high or low pulmonary capillary wedge pressure is not useful to determine ICU outcome. Crit Care Med 2009. Vol 37(12) p. A239.

33. Manji RA, Ashan MW, CATSS Database Group, Kumar A. Patients with septic shock and low cardiac index have inadequate septic treatment and have worse outcomes. Crit Care Med 2009. Vol 37(12) p. A240.

34. Manji RA, Bell DD, Jacobsohn E, Singal RK, Arora RC, Zivot JB, Menkis AH. Consistent outcomes despite sicker prolong stay ICU patients – A measure of improved quality of care? Crit Care Med 2009. Vol 37(12) p. A370.

35. Manji RA, Jacobsohn E, Grocott H, Zivot J, Menkis AH. Prolonged in-hospital wait times do not affect outcomes for urgent coronary artery bypass surgery. American Heart Association, Orlando, Florida, USA, Nov. 18, 2009. Abstract #4704.

36. Kumar K., Hiebert B, Zarychanski R, Bell DD, Singal RK, Manji RA, Zivot JB, Menkis AH, Arora RC. Does the use of twenty-four hour, in-house intensivist staffing model in a dedicated cardiac intensive care unit impact outcomes for prolonged stay (>48 hours) patients? Crit Care Med 2009. Vol 37(12) p. A311.

37. Kumar K, Zieroth SR, Manji RA, Menkis AH, Freed DH. Influenza A (H1N1) causing biventricular failure and multi-limb compartment syndrome. Crit Care Med 2009. Vol 37(12) p. A497.

38. Kumar KK, Azordegan N, Durston M, Li Y, Fischer G, Moghadasian M, Manji RA, Freed DH, Jassal DS, Arora RC. Can statin therapy alter the natural history of bioprosthetic valves? – An in vivo rodent model pilot study. Can J Cardiol 2009, Vol 25 Suppl B p. 85B.

39. Manji RA, Jacobsohn E, Grocott H, Zivot J, and Menkis AH. Prolonged in-hospital wait times do not affect outcomes for urgent coronary artery bypass surgery. Can J Cardiol 2009, Vol 25 Suppl B p. 83B.

40. Manji RA, Warrian K, Pascoe E, Lee J, Arora RC, Freed DH, Singal RK, Menkis AH. Over the past 12 years, elderly patients undergoing coronary artery bypass grafting surgery have become sicker needing more acute care post-op but still have similar mortality rates. Can J Cardiol 2009, Vol 25 Suppl B p.86B.

41. Manji RA, Bell DD, Saw C, Moltzan C, Nickerson P, Menkis AH, Zivot J, Jacobsohn E. Management suggestions for cardiac surgery patients with a positive heparin induced thrombocytopenia (HIT) ELISA. Can J Cardiol 2009 Vol 25 Suppl B p.86B.

42. Manji RA, Jacobsohn E, Bell DD, Singal RK, Zivot J, Menkis AH. Delirium and bed management in the cardiac surgery ICU. Can J Cardiol 2009 Vol 25 Suppl B p.159B.

43. Manji RA, Witt J, Bell DD, Menkis AH, Zivot J, Jacobsohn E. Unfractionated heparin is the least costly method of routine deep venous thrombosis prophylaxis after cardiac surgery in a model considering the diagnosis, treatment and management of heparin induced thrombocytopenia. Can J Cardiol 2009 Vol 25 Suppl B p.159B.

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44. Kumar K, Zarychanski R, Bell D, Manji RA, Zivot J, Menkis AH, Arora RC. The impact of 24 hour in-house intensivist coverage on a dedicated cardiac surgery ICU. Society of Thoracic Surgeons 45th Annual meeting January 2009.

45. Kumar KK, Hiebert B, Zarychanski R, Grocott H, Singal RK, Manji RA, Menkis AH, Arora RC. Twenty-four hour consultant hybrid ICU: addressing the needs of patients post-cardiac surgery. Can J Cardiol 2010, Vol 26 Suppl SD Abstract #612

46. Avery LJ, Tam JW, Menkis AH, Shaikh N, Manji RA. What do non-rehab Cardiac Sciences Health Professionals perceive of and know about cardiac rehab? Journal of Cardiopulmonary Rehabilitation & Prevention, September/October 2010.

47. Manji RA, Grocott H, Leake J, Khan S, Black K, Manji JS, Menkis A, Strumpher J, Jacobsohn E. Intermediate term outcomes in ICU patients with seizures following cardiac surgery. Crit Care Med 2010. Vol 38(12). Abstract 611.

48. Manji RA, Grocott H, Saw C-L, Nickerson, P, Menkis A, Jacobsohn E. What is the usefulness of 4T Test and Enzyme Linked Immunosorbent Assay in decision making in post cardiac surgical ICU patients suspected of heparin induced thrombocytopenia? Crit Care Med 2010. Vol 38(12). Abstract79.

49. Manji RA, Grocott HP, Menkis AH, Jacobsohn E. Which cardiac surgery ICU patients with a positive heparin induced thrombocytopenia ELISA assay are at increased risk for thrombosis? Canadian Critical Care Forum, November 2010, Toronto, Ontario.

50. Manji RA, Witt J, Menkis AH. A short course of low dose prophylactic steroids is cost-effective in cardiac surgery ICU patients at medium to high risk for postoperative atrial fibrillation. Canadian Critical Care Forum, November 2010, Toronto, Ontario.

51. Manji RA, Bell D, Freed DH. Elevated carboxyhemoglobin levels during extra-corporeal membrane oxygenation for acute lung injury – A case report. Canadian Critical Care Forum, November 2010, Toronto, Ontario.

52. Manji RA, Grocott HP, Leake JA, Manji JS, Menkis AH, Ariano R, Strumpher J, Jacobsohn E. Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. Circulation Supplement Vol 122 Issue 21 November 23, 2010 – Abstract 18007

53. Manji RA, Grocott HP, Saw C, Nickerson P, Menkis AH, Jacobsohn E. Correlation of the 4T Test, Enzyme Linked Immunosorbent Assay and the Serotonin Release Assay in post cardiac surgical ICU patients suspected of heparin induced thrombocytopenia. American Society of Critical Care Anesthesiologists meeting October 2010, San Diego, California.

54. Manji RA, Grocott HP, Saw C, Nickerson P, Menkis AH, Jacobsohn E. Thrombosis risk in cardiac surgery ICU patients suspected of having heparin induced thrombocytopenia. American Society of Critical Care Anesthesiologists meeting October 2010, San Diego, California.

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55. Manji RA. Ventricular Arrhythmia: Perioperative management. 12th International Congress on Cardiothoracic and Vascular Anesthesia 2010. Abstract 35. Beijing, China Sept 23, 2010.

56. Manji RA, Bell DD, Loong-Saw C, Nickerson P, Moltzan C, Menkis AH, Jacobsohn E. Treating cardiac surgery patients for heparin-induced thrombocytopenia based on easily available ELISA results. Anesthesia and Analgesia 2010. Vol 110 (3) Abstract 71.

57. Manji RA, Warkentin TE, Grocott HP, Menkis AH, Jacobsohn E. Pre-operative, intra-operative and post-operative factors associated with heparin induced thrombocytopenia post cardiac surgery. Canadian Journal of Cardiology Supplement Vol 27 (5S) September/October 2011 Page S103. Abstract 111.

58. Manji RA, Grocott HP, Menkis AH, Jacobsohn E. Risk factors associated with recurrent seizures following cardiac surgery. Canadian Journal of Cardiology Supplement Vol 27 (5S) September/October 2011 Page S195. Abstract 373.

59. Manji RA, Chartrand S, Arora RC, Rivet M, Jacobsohn E, Bell DD, Menkis AH. Which cardiac surgery patients may be suitable for transfer from ICU the same day as surgery? Canadian Journal of Cardiology Supplement Vol 27 (5S) September/October 2011 Page S197. Abstract 377.

60. Manji RA, Witt J, Menkis AH. Is it cost-effective to give a short course of low dose prophylactic steroids to cardiac surgery ICU patients at medium to high risk for postoperative atrial fibrillation. Canadian Journal of Cardiology Supplement Vol 27 (5S) September/October 2011 Page S288. Abstract 620.

61. Manji RA, Grocott HP, Menkis AH, Jacobsohn E. Recurrent seizures following cardiac surgery - risk factors and outcomes. Circulation Supplement November 22, 2011, 124 (21):A13710

62. Manji RA, Warkentin TE, Grocott HP, Menkis AH, Jacobsohn E. What is the utility of two different ELISAs and the 4T's Score in determining the probability of heparin-induced thrombocytopenia following cardiac surgery? Circulation Supplement November 22, 2011, 124 (21):A13172

63. Villafranca AJ, Arenson B, Grocott H, Manji RA, Jacobsohn E. Is there a difference between cardiac surgical practice between Canada and the US? Can J Anesth (2012) 59:S123 – Abstract 1343388

64. Manji RA, Arora RC, Bell DD, Menkis AH, Jacobsohn E. Can cardiac surgery patients transfer from ICU the same day as surgery? Can J Anesth (2012) 59:S108 – Abstract 1341611

65. Manji RA, Grocott HP, Menkis AH, Jacobsohn E. Which cardiac surgery ICU patients with a positive HIT ELISA are at increased risk for thrombosis? Can J Anesth (2012) 59:S113 – Abstract 1341903

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66. Manji RA, Grocott HP, Menkis AH, Jacobsohn E. Outcomes in ICU patients with seizures post cardiac surgery. Can J Anesth (2012) 59:S111 – Abstract 1341774

67. Manji RA, Witt J, Jung Y, Northcott R, Jacobsohn E, Menkis AH. Determining the most cost-effective method to prevent rheumatic heart disease in a developing world country. Accepted for poster presentation at the American Heart Association Meeting November 4, 2012, Los Angeles, California, USA

68. Manji RA, Grocott HP, Menkis AH, Jacobsohn E. Seizures post cardiac surgery: In-hospital mortality and intermediate term outcomes. Canadian Journal of Cardiology Supplement Vol 28 (5S) September/October 2012 Page S362. Abstract 691.

69. Manji RA, Grocott HP, Menkis AH, Jacobsohn E. Aortic surgery patients with a positive HIT ELISA are at increased risk of thrombosis. Canadian Journal of Cardiology Supplement Vol 28 (5S) September/October 2012 Page S360. Abstract 687.

70. Manji RA, Witt J, Menkis AH. Is it more cost-effective to use steroids or colchicine in patients at moderate to high risk for atrial fibrillation to prevent post-cardiac surgery atrial fibrillation? Canadian Journal of Cardiology Supplement Vol 28 (5S) September/October 2012 Page S384. Abstract 742.

71. Manji RA Witt J, Menkis AH. What is the most cost effective method to prevent atrial fibrillation in patients at medium to high risk for post cardiac surgery atrial fibrillation? Society of Critical Care Anesthesiologists Annual Meeting, Oct. 2013 San Francisco, California, USA.

72. Kumar K, Azordegan N, Durston M, Li Y, Fischer G, Moghadasian M, Manji RA, Freed DH, Jassal RC, Arora RC. HMG-COA reductase inhibitors do no attenuate the inflammatory response associated with glutaraldehyde-fixed bioprosthetic heart valve conduits. Can J Cardiol. 2013 Oct; 29(10):S261.

73. Manji RA, Northcott R, Menkis AH. Cardiovascular risk profile in a developing world country – Rural versus urban differences. Can J Cardiol. 2013 Oct; 29(10):S278.

74. Manji RA, Witt J, Jung Y, Northcott R, Menkis AH. What is the most cost-effective method to prevent rheumatic heart disease in a developing world country? Can J Cardiol. 2013 Oct; 29(10):S324.

75. Manji RA, Northcott R, Menkis AH. Cardiovascular disease risk perception in a developing world country – based on location of residence and gender. Can J Cardiol. 2013 Oct; 29(10):S324-S325.

76. Nepomuceno R, White CW, Muthiah K, Bueddefield D, Hiebert B, Arora RC, Manji RA, Freed DH, Moffatt D. Gastrointestinal hemorrhage in adults requiring extracorporeal membrane oxygenation: Incidence, clinical predictors, and impact on outcomes. Can J Cardiol. 2013; 29(10):S373-S374.

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77. Villafranca A, Manji RA, Thomson IA, Arenson B, Lucht J, Jacobsohn E. Differentiation of Heparin and Non-Heparin Induced Thrombocytopenia Through Early Platelet Measures. Can J Cardiol. 2013; 29(10):S226-S227.

78. Manji RA, Villafrance A, Grocott H, Menkis AH, Jacobsohn E. Diagnosing heparin induced thrombocytopenia post cardiac surgery. American Heart Association Meeting November 2013, Dallas, Texas USA

79. Manji RA, Menkis AH, Cooper DKC. Xenograft rejection of bioprosthetic heart valves. Xenotransplantation 2013; 20(5):361

80. Manji RA, Rayner D. Do bioprosthetic heart valves undergo xenograft rejection in patients? Xenotransplantation 2013; 20(5):373.

81. Manji RA, Rayner D. Anti-alpha-Gal antigen/antibody may not be important in the failure of bioprosthetic heart valves. Xenotransplantation 2013:20(5):336.

82. Manji RA, Villafranca A, Grocott H, Menkis AH, Jacobsohn E. Testing for Heparin Induced Thrombocytopenia After Cardiac Surgery. Electronic (moderated) Poster Presentation at Canadian Anesthesiologist Society Meeting June 13-16, 2014, St. John’s, Newfoundland.

83. Manji RA, Hiebert BM, Arora RC, Moon MC, Freed DH, Menkis AH. Readmission rates and diagnoses for prolonged intensive care unit stay survivors following cardiac surgery. Can J Cardiol. 2014; 30(10S):S231.

84. Manji RA, Hiebert BM, Arora RC, Moon MC, Freed DH, Menkis AH. Social Assistance requirements and mental health issues of patients needing prolonged intensive care unit stay following cardiac surgery. Can J Cardiol. 2014;30(10S):S235.

85. Bednarczyk JM, Ducas RA, White CW, Golian M, Nepomuceno R, Bueddefeld D, Hiebert B, Manji RA, Singal RK, Hussain F, Freed DH. Extracorporeal membrane oxygenation facilitates survival in refractory in-hospital cardiac arrest and cardiogenic shock. Can J Cardiol. 2014; 30(10S):S242.

86. Manji RA, Hiebert B, Arora RC, Moon MC, Freed DH, Menkis AH. Characteristics, long-term survival and predictors of mortality of patients needing prolonged intensive unit care stay post cardiac surgery. Podium presentation at University of Manitoba Department of Surgery Research Day – January 19, 2015 – Winnipeg, Manitoba.

87. Manji RA, Hiebert B, Arora RC, Moon MC, Freed DH, Menkis AH. Long Term Survival and Predictors of Mortality in Patients Needing Prolonged Intensive Unit Care Stay Post Cardiac Surgery. Podium presentation at the Society of Thoracic Surgery Meeting (Abstract 1542) – San Diego, California – January 26, 2015.

88. Dubiel C, Hiebert B, Tangri N, Rudolph JL, Singal RK, Manji RA and Arora RC. Delirium After Cardiac Surgery – Definition Does Matter. Podium presentation at the 10th Scientific Congress of the European Delirium Association, Sept 3, 2015 --- London, United Kingdom

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89. Jung Y, Witt J, Arora RC, Manji RA. What Is The Most Cost Effective Pharmacological Method To Prevent Delirium Post-Cardiac Surgery? Can J Cardiol. 2015; 31(10S):S171

90. Lee W, Long C, Hara H, Cooper D, Ramsoondar J, Ayares D, Manji RA. The potential significance of NeuGc in the structural valve deterioration of bioprosthetic heart valves. Podium presentation at the International Xenotransplantation Association Meeting – November 17, 2015 – Melbourne, Australia.

91. Manji RA, Arora RC, Singal RK, Hiebert B, Menkis AH. Determinants of Rehospitalization after Cardiac Surgery in Prolonged ICU Length of Stay Survivors. Poster presentation at the American Heart Association Meeting, Orlando, Florida, Nov 7-11, 2015

92. Manji RA, Singal RK, Hiebert B, Menkis AH, Arora RC. Outcomes of Octogenarians Discharged Home after prolonged ICU length of stay after cardiac surgery. Podium presentation at the American Association for Thoracic Surgery (AATS) Meeting, Baltimore, MD, USA. May 16, 2016.

93. Arora RC, Dubiel C, Hiebert B, Tangri N, Rudolph J, Singal RK, Manji RA. Delirium After Cardiac Surgery – Definition Does Matter. Podium presentation at the American Delirium Society Meeting, Nashville, TN, USA. June 2, 2016

94. Manji RA, Arora RC, Singal RK, Hiebert B, Bohm C, Komenda P, Tangri N, Rigatto, C, Menkis AH. Long-Term Functional Survival of Cardiac Surgery Patients with Prolonged ICU Length of Stay and New Acute Renal Failure. Can J Cardiol. 2016; 32(10S1):S230

95. Manji RA, Singal RK, Hiebert B, Jacobsohn E, Menkis AH, Arora RC. Development of a risk calculator to predict non-institutionalized survival in patients with prolonged length of stay after cardiac surgery. Can J Cardiol. 2017; 33(10S):S94

96. Cozzi E, Roussel J-C, Galiñanes M, Costa C, Takeuchi Y, Padler-Karavani V, Breimer M, Galli C, Pascual M, Gerosa G, Le Tourneau T, Bottio T, Nonell-Canals A, Chen X, Manji R, Nassi A, Vadori M, Mañez R, Soulillou J-P. Translink: A EU project aimed at studying the immune response in patient recipients of biological heart valves. Xenotransplantation 2017: 24:45-6.

97. Manji RA, MacDonald KJ, Le K, Moghadasian M, Manji J, Ravandi A, Menkis AH and Arora RC. Does aortic stenosis have an autoimmune component? American Heart Association Meeting – Nov 10, 2018 – Chicago, Illinois

98. Manji RA, Northcott R, Manji J, Menkis AH, Arora RC. Cardiovascular Disease Risk Profile in a Low Middle Income Country – Rural versus Urban Differences. Consortium of Universities for Global Health 10th Anuual Meeting - 2019 – E-poster Sat_03.07, https://posterng.netkey.at/cugh/viewing/index.php module=viewing_poster&task=&pi=688&searchkey=060ce26c4c31c417a52d092835a839c

99. Eikelboom R, Arora RC, Manji RA. Identifying a Gap Between Canadian Interest and Involvement in Humanitarian Cardiac Surgery. Can J Cardiol. 2019; 35(10S):S126

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Other Abstracts 1. Manji RA, Manji JS, Rajotte RV, Korbutt GS, Koshal A. Development of an ex-vivo porcine

working heart model to test various immunoadsorbants for porcine to human xenotransplantation. General Surgery Resident Research Day, University of Alberta, Edmonton Alberta. Apr 1999.

2. Manji RA, Manji JS, Rajotte RV, Koshal A. Specific α-gal antibody removal and human ABO blood group in human=porcine cardiac xenograft survival. 4th Annual Cardiac Sciences Research Day, University of Alberta, Edmonton, Alberta, June 2000.

3. Manji RA, Manji JS, Rajotte RV, Korbutt GS, Koshal A. Testing the efficacy of specific anti-α-gal antibody depletion at prolonging survival of an ex-vivo porcine working heart in porcine-human cardiac xenotransplantation. General Surgery Resident Research Day. University of Alberta, Edmonton, Alberta. Apr. 2000.

4. Manji RA, Manji JS, Rajotte RV, Koshal A. Critical factors in porcine-human Xenotransplantation. Department of Surgery Resident Research Day, University of Alberta, Edmonton, Alberta, May 2001.

5. Manji RA, Manji JS, Rajotte RV, and Koshal A. Critical factors in survival of a pig-human xenograft. 5th annual Cardiac Sciences Research Day. University of Alberta, Edmonton, Canada. June 2001.

6. Manji RA, Manji JS, Rajotte RV, Korbutt GS, Koshal A. Human red blood cells in pig-human cardiac xenotransplantation. 6th Annual Cardiac Sciences Research Day University of Alberta, Edmonton, Alberta, Canada. June 2002.

7. Manji JS, Manji RA, Rajotte RV, Korbutt GS, Koshal A. Decreased apoptosis in α-gal antibody depleted human plasma perfused porcine working cardiac xenografts. 6th Annual Cardiac Sciences Research Day, University of Alberta, Edmonton, Canada. June 2002.

8. Manji JS, Manji RA, Rajotte RV, Korbutt GS, Koshal A. Human ABO blood group antibodies and pig-to-human cardiac xenotransplantation. 6th Annual Cardiac Sciences Research Day. University of Alberta, Edmonton, Canada June 2002.

9. Manji RA, Manji JS, Rajotte RV, Korbutt GS, Koshal A. Human red blood cells in porcine-human cardiac xenotransplantation. Department of Surgery Resident Research Day, University of Alberta, Edmonton, Canada May 2002.

10. Manji RA, Rayner D, Woolsey J, Nijjar N, Rajotte R, Koshal A, Ross D. Are glutaraldehyde-fixed bioprosthetic heart valves truly inert? Cardiac Sciences Research Day, Edmonton, Canada June 2004.

11. Manji RA, Nijjar N, Woolsey J, Rayner D, Rajotte R, Koshal A, Ross D. Is anti-α-gal antibody involved in the failure of glutaraldehyde fixed bioprosthetic heart valves? Cardiac Sciences Research Day Edmonton, Alberta June 2004.

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12. Kumar K, Durston M, Azordegan N, Bulman C, Moghadasian M, Manji RA, Jassal DS, Arora RC. Bioprosthetic valve implantation in a rodent model: analysis of the immunological response. Institute of Cardiac Sciences Research Day, University of Manitoba, Winnipeg, Manitoba. November 2008.

13. Kumar K, Azordegan N, Durston M, Li Y, Fischer G, Moghadasian M, Manji RA, Freed DH, Jassal DS, Arora RC. Statins compared to steroids on bioprosthetic heart valve inflammation – An In- vivo rodent model study. Institute of Cardiovascular Sciences Research Day, November 2010, Winnipeg, Manitoba.

14. Love K, Shah P, Kuol K, Hiebert B, Menkis A, Manji R, Arora R. Predictors of functional survival and hospital re-admission in octogenarians after surgical aortic valve replacement: A 20 year longitudinal follow-up study. Poster presentation at the Institute of Cardiovascular Sciences Research Day. Nov. 30, 2015.

15. Whayoung L, Hidetaka H, Cooper DKC, Manji RA. The potential significance of xenoantigens in the structural valve deterioration of bioprosthetic heart valves. Podium presentation at the University of Manitoba Dept. of Surgery Research Day. Jan 13, 2016.

16. Manji RA, Singal RK, Hiebert B, Jacobsohn E, Menkis AH, Arora RC. Development of a risk calculator to predict non-institutionalized survival in patients with prolonged length of stay after cardiac surgery. Plenary presentation at the University of Manitoba Dept. of Surgery Research Day. Jan 17, 2018.