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CURRICULUM VITAE

Personal Particulars

Name : PROF. DR. JOHNSON STANSLAS Unit/Department : Pharmacotherapeutics Unit, Department of Medicine Faculty : Faculty of Medicine and Health Sciences Field of Specialisation : Pharmacology and Therapeutics Cancer Research (Cancer Pharmacology)

Drug Discovery and Development Contact number : Office : 03-89472310 Fax: 03-89472759 E-mail : rcxjs@upm.edu.my; jstanslas@yahoo.com Membership of Professional Organisations

American Society for Pharmacology and Experimental Therapeutics (ASPET)

American Association for Cancer Research (AACR)

British Association for Cancer Research (BACR)

European Association for Cancer Research (EACR)

Malaysian Oncological Society (MOS)

Malaysian Society for Neuroscience (MSN)

Malaysian Society for Music in Medicine (MSMM)

Education and Academic Qualifications BSc (Hons), Faculty of Life Sciences, National University of Malaysia (UKM); MSc (Anticancer Research), Faculty of Life Sciences, National University of Malaysia (UKM); PhD (Cancer Pharmacology), School of Pharmacy, The University of Nottingham, United Kingdom Teaching experience Teaching activities

Code and Name of Courses

BMS 5021/6021 MOLECULAR PHARMACOLOGY

SPP3271 GENERAL AND BIOCHEMICAL PHARMACOLOGY

SPP3531 CARDIOVASCULAR SYSTEM - PHARMACOLOGY

SPP3521 URINARY SYSTEM - PHARMACOLOGY

SPP3581 CENTRAL NERVOUS SYSTEM - PHARMACOLOGY

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SPP3561 ENDOCRINE SYSTEM - PHARMACOLOGY

NUR 3102/ BASIC BIOCHEMISTRY AND PHARMACOLOGY

YEAR 3 MD PROGRAMME - INTRODUCTORY MEDICINE - PHARMACOLOGY

MASTER OF PSYCHIARTY - NEUROPHARMACOKINETICS

MEDICAL NEUROSCIENCES - NEUROPHARMACOLOGY

BMS 3040 PHARMACOLOGY

BMS 3150 TOXICOLOGY

BMS 3020 BASIC MEDICAL BIOCHEMISTRY

BMS 3021 CLINICAL BIOCHEMISTRY

SPP3211 CELLS AND TISSUES

SPP3231 MOLECULAR BASIS OF MEDICINE I

SPP3232 MOLECULAR BASIS OF MEDICINE II

SPP3231 MOLECULAR BASIS OF MEDICINE

SPP3231 MOLECULAR BASIS OF MEDICINE

SPP3233 MOLECULAR MEDICINE

PSK5905 SPECIAL TOPICS

SPS6903 SEMINAR PROPOSAL PRESENTATION

SPP3591 PROBLEM BASED LEARNING I

SPP3591 PROBLEM BASED LEARNING II

Invited lectures

International Union of Basic and Clinical Pharmacology (IUPHAR) World Conference on the Pharmacology of Natural and Traditional Medicine “Targeting K-Ras with Semisynthetic Andrographolide Derivatives: A Valid Approach in the Discovery of Potential Anticancer Drug Leads”, National University of Singapore, 22-24 July 2015.

Invited lecture at School of Biomolecular Science, School of Pharmacy, University of Nottingham, “Exploring Malaysian Biodiversity: A Rich Source of Natural Drug Prototypes”, United Kingdom, 16th December 2011.

Seminar on Computer Aided Drug Design Organised by School of Pharmaceutical Sciences, USM & Malaysian Institute of Pharmaceutical and Nutraceutical (IPHARM) – 2-8 December 2010

1st Malaysian Biotechnology Seminar ‘Evaluation of New Andrographolide Derivatives for Inhibitory Activities against Tumour Vasculature and Metastasis’ - 24 – 26 May 2010

UK-Malaysia Symposium On Drug Discovery And Development For Cancer Organised by Cancer Research Initiatives (CARIF) ‘Andrographolide, a Versatile Template in the Synthesis of Tumour-Selective and Potent Anticancer Agents’ - 24-25 February 2010

Indonesian Natural Products Conference 2009 – Plenary Lecture ‘A Decade of Research on Andrographis Paniculata: The Story So Far’

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Andalas University, West Sumatra, Indonesia, Department of Pharmacy, “Discovery and Development of Anticancer Agents: Incorporating the Experience of the Cancer Research and Drug Discovery Group of UPM”, August 2007.

Universiti Technology MARA (UiTM), Malaysia; Faculty of Pharmacy, “Current Advances in Antineoplastic Research”, March 2008.

Malaysian Oncological Society Meeting, Sabah 2008: Symposium Lectures

1. New Drug Discoveries 2. Translational Research in Oncology (TRiO) in Malaysia: the way forward

Discovery and Development of Natural and Synthetic Anticancer Agents. International Conference: Exploring New Frontiers in Medicine and Health. 1-2 August 2006, PWTC, Kuala Lumpur

Publications

a. Cited Journals

1. Tan, S.F, Masoumi, H.R.F., Karjiban, R.A., Stanslas J., Kirby, B.P., Basri, M., Basri, H (2016) Ultrasonic emulsification of parenteral valproic acid-loaded nanoemulsion with response surface methodology and evaluation of its stability. Ultrasonics Sonochemistry 29 (2016) 299–308. 2. Daood, G.S., Basri, H., Stanslas, J., Masoumi, H.R.F and Basri, M (2015) Predicting the optimum compositions of a parenteral nanoemulsion system loaded with azithromycin antibiotic utilizing the artificial neural network model. RSC Advances. 5, 82654–82665. 3. Tan SL, Stanslas J, Basri M, Abedi Karjiban RA, Kirby B, Sani D, Basri HB (2015) Nanoemulsion-based parenteral drug delivery system of carbamazepine: Preparation, characterization, stability evaluation and blood-brain pharmacokinetics. Current Drug Delivery Sep 1. 4. Wahyuni, F.S., Stanslas, J., Lajis, N.H., Dachriyanus. (2015). Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line. International Journal of Pharmaceutical Sciences Review and Research, 32(2):166–168. 5. Wahyuni, F.S., Shaari, K., Stanslas, J., Hj. Lajis, N., Dachriyanus. (2015). Cytotoxic xanthones from the stem bark of Garcinia cowa Roxb. Journal of Chemical and Pharmaceutical Research, 7(1): 227-236. 6. Wahyuni, F.S., Stanslas, J., Lajis, N.H., Dachriyanus. (2015) Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (3): 60-63. 7. Wahyuni, F.S., Shaari, K., Stanslas, J., Lajis, N., Hamidi, D. (2015) Cytotoxic compounds from the leaves of Garcinia cowa Roxb. Journal of Applied Pharmaceutical Science, 5 (2): 006-011.

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8. Lim, J.C.W., Jeyaraj, E.J., Sagineedu, S.R., Wong, W.S.F., Stanslas, J. (2015). SRS06, a New Semisynthetic Andrographolide Derivative with Improved Anticancer Potency and Selectivity, Inhibits Nuclear Factor-κB Nuclear Binding in the A549 Non-Small Cell Lung Cancer Cell Line. Pharmacology, 95: 70-77. [IF = 2.093]@; citations – 4 Quartile ranking: Q3 9. Wong C.C., Sagineedu S.R., Sumon S.H., Sidik M.S., Phillips R., Lajis N.H., Stanslas J. (2014). NCI In Vitro and In Silico Anticancer Screen, Cell Cycle Pertubation and Apoptosis-Inducing Potential of New Acylated, Benzylidene and Isopropylidene Derivatives of Andrographolide. Environmental Toxicology and Pharmacology, 38(2): 489–501 [IF = 2.093]@; citations – 3 Quartile ranking: Q2. 10. Wong H.C., Wong C.C., Sagineedu S.R., Loke S.C., Lajis N.H., Stanslas, J. (2014). SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells. Cell Biology and Toxicology, DOI: 10.1007/s10565-014-9282-5. [IF = 2.067]@; citations – 0 Quartile ranking: Q3. 11. Wong C.C., Periasamy, N., Sagineedu, S.R., Sidik, S., Sumon, S.H., Loadman, P., Phillips, R., Lajis, L.H., Stanslas, J. (2014). In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog. Investigational New Drugs, DOI: 10.1007/s10637-014-0105-6. [IF = 2.801]@; citations – 0 Quartile ranking: Q2. 12. Moyeenul Huq, A. K. M., Jamal, J.A., Stanslas, J. (2014). Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects of Persicaria hydropiper (L.) Delarbre. Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 782830, 11 pages. [IF = 2.286]@; citations – 0 Quartile ranking: Q2. 13. Chew YL, Lim YY, Stanslas J, Ee GCL, Goh JK. (2014) Bioactivity-guided Isolation of Anticancer Agents from Hauhinia Kockiana Korth. African Journal of Traditional Complementary Alternative Medicine. 11(3):291-299. [IF = 0.951]@ citations – 0 Quartile ranking: Q4. 14. Ashraf, M.F., Abd Aziz, M., Stanslas, J., Ismail, I., Abdul Kadir, M. (2013). Assessment of antioxidant and cytotoxicity activities of saponin and crude extracts of chlorophytum borivilianum. The Scientific World Journal 2013: 216894. citations – 1 Quartile ranking: Q2. 15. Nasir, N.M., Rahmani, M., Shaari, K., Kassim, N.K., Go, R., Stanslas, J., Jeyaraj, E.J. (2013). Xanthones from Calophyllum gracilipes and their cytotoxic activity. Sains Malaysiana 42(9): 1261-1266. citations – 0 Quartile ranking: Q3. 16. Abdul Latip A.F., Hussein M.Z., Stanslas J., Wong C.C., Adnan R (2013). Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound. Chemistry Central Journal 7(1): 119. [IF = 2.071]@; citations – 0 Quartile ranking: Q2. 17. Ashraf M.F., Aziz M.A., Kadir M.A., Stanslas J., Farokhian E. (2013). In Vitro Tuberization of Chlorophytum Borivilianum Sant & Fern (Safed Musli) As Influenced by Sucrose, CCC and Culture Systems. Plant and Cell Physiology 54(8): 1356-1364. [IF = 4.972]@; citations – 0 Quartile ranking: Q1.

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18. Hocker H.J., Cho H.J., Chen C.Y.K., Maharaj N., Wong C.C., Wong H.C., Sagineedu S.R., Shaari K., Stanslas J., Hancock J.F., Gorfe A.A. (2013). Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function. Proceedings of the National Academy of Sciences of USA 110(25): 10201-10206. [IF = 10.727]@; citations – 34 Quartile ranking: Q1. 19. Hasan S., Basri H.B., Hin L.P., Stanslas J. (2013). Encephalitis followed by optic neuritis: A case report and review of literature. Pakistan Journal of Medical Sciences 29(3):859-862. [IF = 0.156]@; citations – 0 Quartile ranking: Q4. 20. Al-Mekhlafi N.A., Shaari K., Abas F., Jeyaraj E.J., Khallivulla S.I., Stanslas J., Lajis N.H. (2013). New Flavan and Alkyl α,β-Lactones from the Stem Bark of Horsfieldia superba. Natural Products Communication 8(4): 447-451. [IF = 0.956]@; citations – 1 Quartile ranking: Q4. 21. Wong M.S., Sidik S.M., Mahmud R., Stanslas J. (2013). Molecular targets in the discovery and development of novel antimetastatic agents: Current progress and future prospects. Clinical Experimental Pharmacology and Physiology 40(5):307-1. [IF = 2.067]@; citations – 8 Quartile ranking: Q2. 22. Ashraf M.F., Aziz M.A., Stanslas J., Kadir M.A. (2013). Optimization of immersion frequency and medium substitution on microtuberization of Chlorophytum borivilianum in RITA system on production of saponins. Process Biochemistry, 48(1): 73-77. [IF = 2.922]@; citations – 2 Quartile ranking: Q1. 23. Ooi C.T., Syahida A., Stanslas J., Maziah M. (2013). Efficiency of different Agrobacterium rhizogenes strains on hairy roots induction in Solanum mammosum. World Journal of Microbiology and Biotechnology, 29: 421-430. citations – 2 24. Hasan M.S., Stanslas J., Lim P.H., Basri H.B. (2013). Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the asian population requires special attention. International Journal of Neurosciences. 123(3): 143-154. [IF = 0.967]@; citations – 5 Quartile ranking: Q4. 25. Saha K., Lam S.K., Abas F, Hamzah A.S., Stanslas J., Lim S.H., Lajis N.H. (2012). Synthesis of damnacanthal, a naturally occuring 9,10-anthraquinone and its analogues, and its biological evaluation againt five cancer cell lines. Medicinal Chemistry Research 22(5): 2093-2104. [IF = 1.612]@; citations – 3 Quartile ranking: Q3. 26. Jabir R.S., Naidu R., Azrif A.A., Ho G.F., Munisamy M., Stanslas J. (2012). Pharmacogenetics of Taxanes: Impact of Gene Polymorphisms of Drug Transporters on Pharmacokinetics and Toxicity. Pharmacogenomics, 13(16): 1979-1988.[IF = 3.439]@; citations – 4; Quartile ranking: Q1; #CA 27. Jamal J.A., Ramli N., Stanslas J., Husain K. (2012). Estrogenic activity of selected Myrsinaceae species in MCF-7 human breast cancer cells. International Journal of Pharmacy and Pharmaceutical Sciences, 4, Suppl 4: 547-553. Scopus indexed; citations – 2; *CAU. 28. Hasan M.S., Stanslas J., Lim P.H., Basri H.B. (2012). A young lady with thalamic stroke mimicking acute Miller Fisher syndrome. Neurosciences, 17(4): 7-8. [IF = 0.121 ]@; citations – 0; Quartile ranking: Q4

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29. Al-Mekhlafi N.A., Shaari K., Abas F., Kneer R., Jeyaraj E.J., Stanslas J., Yamamoto N., Honda T., Lajis N.H. (2012). Alkenylresorcinols and cytotoxic activity of the constituents isolated from Labisia pumila. Phytochemistry, 80: 34-49. [IF = 3.571]; citations – 4; Quartile ranking: Q1 30. Lim C.W., Chan T.K., Ng S.W.D., Sagineedu S.R., ^Stanslas J., ^Wong W.S.F. (2012). Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clinical and Experimental Pharmacology and Physiology, 39(3): 300-310. [IF = 2.067]; citations – 48; Quartile ranking: Q2; *CAU (^ - equal contribution). 31. Hasan MS, Basri H.B., Lim P.H., Stanslas J. (2011). Surgical remotion of a cysticercotic granuloma responsible for refractory seizures: A case report. Surgical Neurology International, 2:177 ; citations – 1 32. Shaari K., Suppaiah V., Wai L.K., Stanslas J., Tejo B.A., Israf D.A., Abas F., Ismail I.S., Shuaib N.H., Zareen S., Lajis N.H. (2011). Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelifolia and molecular insights into its interaction with 5-lipoxygenase. Bioorganic & Medicinal Chemistry, 19(21): 6340-6347. [IF = 3.205]; citations – 3; Quartile ranking: Q2 33. Chew Y.L., Chan E.W.L., Tan P.L., Lim Y.Y., Stanslas J., Goh J.K. (2011). Assessment of phytochemical content, polyphenolic composition, antioxidant and antibacterial activities of Leguminosae medicinal plants in Peninsular Malaysia. BMC Complementary and Alternative Medicine, 11:12. [IF = 2.343]; citations – 17; Quartile ranking: Q1; *CAU 34. Wong H.C., Sagineedu S.R., Lajis N.H., Loke S.C. and Stanslas J. (2011). Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells. African Journal of Pharmacy and Pharmacology, 5(2): 225-233. [IF = 0.875]; citations – 3; Quartile ranking: Q4; #CA 35. Bagalkotkar G., Tang S.C., Khalivulla S.I., Hamzah A.S., Shaari K., Lajis N.H., Saad M.S. and Stanslas J. (2011). Isolation and cytotoxicity of triterpenes from the roots of Phyllanthus pulcher Wall. ex Müll. Arg. (Euphorbiaceae). African Journal of Pharmacy and Pharmacology, 5(2): 183-188. [IF = 0.875]; citations – 4; Quartile ranking: Q4; #CA 36. Nobakht G.M., Kadir A.M., Stanslas J. (2010). Analysis of preliminary phytochemical screening of Typhonium flagelliforme. African Journal of Biotechnology, 9 (11): 1655-1657. [IF = 0.574]@; citations – 2; Quartile ranking: Q4. 37. Sulaiman M.R., Zakaria Z.A., Abdul Rahman A., Mohamad A.S., Desa M.N., Stanslas J., Moin S., Israf D.A. (2010). Antinociceptive and Antiedematogenic Activities of Andrographolide Isolated From Andrographis paniculata in Animal Models. Biological Research for Nursing, 11 (3): 293-301. [IF = 1.385]; citations – 14; Quartile ranking: Q1 38. Nobakht G.M., Kadir A.M., Stanslas J. (2009). In vitro mass propagation of Typhonium flagelliforme as affected by plant growth regulators. African Journal of Biotechnology, 8 (24): 6840-6843. [IF = 0.574]@; citations – 1; Quartile ranking: Q3

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39. Maulidiani, Shaari K., Paetz C., Stanslas J., Abas F., Lajis N.H. (2009). Naturally occurring labdane diterpene and benzofuran from Globba pendula. Natural Product Communications, 4(8):1031-1036. [IF = 1.019]; citations – 1; Quartile ranking: Q2. 40. Vasudevan R., Ismail P., Stanslas J., and Shamsudin N. (2009). Analysis of three genetic polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects. African Journal of Biotechnology, 8(10): 2069-2075. [IF = 0.574]@; citations – 2; Quartile ranking: Q3. 41. Ramachandran V., Ismail P., Stanslas J., Shamsudin N. (2009). Analysis of renin-angiotensin aldosterone system gene polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects. Cardiovascular Diabetology, 8:11. [IF =3.521]; citations – 11; Quartile ranking: Q2. 42. Jabit M.L., Wahyuni F.S., Khalid R., Israf D. A., Shaari K., Lajis N.H. and Stanslas J. (2009). Cytotoxic and Nitric Oxide Inhibitory Activities of Methanol Extracts of Garcinia Species. Pharmaceutical Biology, 47(11): 1019-1026.[IF =1.1856]; citations – 7; Quartile ranking: Q3; #CA

43. Manikam S.D., and Stanslas J. (2009). Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis. Journal of Pharmacy and Pharmacology, 51, 69-78. [IF = 2.326]; citations – 19; Quartile ranking: Q3; #CA

44. Ahamed M.E., Ahmed M.E., Eltoum A.M., Altahir G.O., Ahmed K.M., Harbi S.O., Stanslas J., and Mohamed A.O. (2008). Abnormal proteins in primary breast cancer tissues from 25 Sudanese patients. European Journal of Inflammation, 6:115-121. [IF = 0.990]@; citations – 3; Quartile ranking: Q4. *CAU

45. Nor Aini A.S., Merrina A., Stanslas J. and Sreeramanan S. (2008). Cytotoxic Potential on Breast Cancer Cells Using Selected Forest Species Found in Malaysia. International Journal of Cancer Research, 4(3): 103-109; citations – 0;

46. Jada S.R., Matthews C., Saad M.S., Hamzah A.S., Lajis N.H., Stevens M.F.G. and Stanslas J. (2008). Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 arrest and apoptosis. British Journal of Pharmacology, 155(5):641-654. [IF = 4.994]@; citations – 31; Quartile ranking: Q1; #CA

47. Vasudevan R., Ismail P., Stanslas J., Shamsudin N. (2008). Association of G2350A polymorphism of angiotensin converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects. Journal of Biological Sciences. 8(6): 1045-1050. citations – 7;

48. Vasudevan R., Ismail P., Stanslas J., Shamsudin N., and Ali A.B. (2008). Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. International Journal of Biological Sciences, 4(6):362-367. [IF = 4.223]@; citations – 7; Quartile ranking: Q1 49. Vasudevan R., Ismail P., Stanslas J., Shamsudin N., Moin S. and Jas R.M. (2008). Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects. Journal of the Renin-Angiotensin-Aldosterone System, 9(4):208-214. [IF = 2.000]; citations – 16; Quartile ranking: Q3.

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50. Muniandy S.V., and Stanslas J. (2008). Modelling of chromatin morphologies in breast cancer cells undergoing apoptosis using generalized Cauchy field. Computerized Medical Imaging and Graphics, 32(7):631-637. [IF = 1.707]; citations – 12; Quartile ranking: Q3; *CAU 51. Vasudevan R., Ismail P., Stanslas J. and Shamsudin N. (2008). C-511T polymorphism of interleukin-1 b gene is not associated in type 2 diabetes mellitus – a study in Malaysian population. Journal of Medical Sciences, 8(3):216-221; citations – 1; 52. Vasudevan R., Ismail P., Stanslas J. and Shamsudin N. (2008). No association of BgII dimorphism in human renin gene in hypertensive subjects in Malaysia. Research Journal of Biological Sciences, 3(10):1218-1222; citations – 0; 53. Jabit M. L., Khalid R., Abas F., Shaari K., Hui L. S., Stanslas J., and Lajis N. H. (2007). Cytotoxic xanthones from Garcinia penangiana Pierre. Z. Naturforsch, 62c: 786-792. [IF = 0.776] citations – 7; Quartile ranking: Q4 54. Khalid R. M., Jabit M. L., Abas F., Stanslas J., Shaari K., and Lajis N. H. (2007). Cytotoxic Xanthones from the Leaves of Garcinia urophylla. Natural Product Communication. 2(3), 271-276. [IF = 1.019] citations – 7; Quartile ranking: Q2 55. Wijayahadi N., Haron M. R., Stanslas J., Yusuf Z. (2007). Changes in Cellular Immunity during Chemotherapy for Primary Breast Cancer with Anthracycline Regimens. Journal of Chemotherapy. 19, 716- 723. [IF = 0.969]; citations – 10; Quartile ranking: Q4; *CAU. 56. Jada S.R., Subur G.S., Mathews C., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F. and Stanslas J. (2007). Semisynthesis and in vitro anticancer activities of andrographolide analogues. Phytochemistry, 68: 904-912. [IF = 3.571]; citations – 77; Quartile ranking: Q1; #CA. 57. Sagineedu S.R., Ng S-L., Razak I.A., Fun H-K., Lajis N.H. and Stanslas J. (2006). 3,19-(2,6-dimethoxybenzyledine)andrographolide. Acta Crystallography. E62: o5806-o5808. [IF = 0.499]; citations – 1; Quartile ranking: Q4; #CA

58. Abas F., Lim S.H., Ahmad S., Shaar, K., Stanslas J., Israf D.A., Lajis N.H. (2006). Biological Evaluation of Curcumin and Related Diarylheptanoids. Z. Naturforsch, 61c: 625-631. [IF = 0.776]; citations – 10; Quartile ranking: Q4 59. Bagalkotkar G., Sagineedu S.R., Saad M.S. and Stanslas J. (2006). Phytochemicals from Phyllanthus niruri and their pharmacological properties: a review. Journal of Pharmacy and Pharmacology, 58 (12): 1559-1570. [IF = 2.326]; citations – 63; Quartile ranking: Q2; #CA 60. Jada S.R., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F. and Stanslas J. (2006). Semisynthesis and cytotoxic activities of andrographolide analogues. Journal of Enzyme Inhibition and Medicinal Chemistry, 21(2): 145-155. [IF = 1.815]; citations – 27; Quartile ranking: Q3; corresponding #CA 61. Jada S.R., McMillan K., Hamzah A.S., Saad M.S., Lajis N.H., Stevens M.F.G., Schwalbe C.H. and Stanslas J. (2006). 14-acetylandrographolide. Journal of Chemical Crystallography, 36(2):93-97. [IF = 0.488]; citations – 2; Quartile ranking: Q4; #CA

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62. Ng S-L., Sagineedu S.R., Razak I.A., Fun H-K, Jada S.R. and Stanslas J., (2006). 3,19-(2-bromobenzyledine)andrographolide. Acta Crystallography. E62: o592-o594. [IF = 0.499]; citations – 1; Quartile ranking: Q4; #CA 63. Teh B-J., Sagineedu S,R., Fun H-K., Razak I.A., Lajis N.H. and Stanslas J. (2006). 14-Deoxy-11,12-didehydro-3,19-isopropyledineandrographolide. Acta Cryst. E62: o589-o591. [IF = 0.499]; citations – 1; Quartile ranking: Q4; #CA 64. Abas F., Lajis N.H., Shaari K., Israf D.A., Stanslas J., Yusuf U.K., and Raof S.M. (2005). A New Labdane Diterpene Glucoside from the Rhizomes of Curcuma mangga. Journal of Natural Products, 68: 1090-1093. [IF = 3.947]; citations – 51; Quartile ranking: Q1. 65. Ariffin H., Muthukumaran T., Stanslas J., Sabariah A.R., Veerasekaran N., Lin H.P., (2005). Secondary B-cell acute lymphoblastic leukaemia following Wilms’ tumor: Clinical and in vitro chemosensitivity studies. Leukaemia and Lymphoma, 46(8): 1233-1237. [IF= 2.605]@; citations – 2; Quartile ranking: Q2; *CAU. 66. Permana D., Abas F., Maulidiani Shaari, K., Stanslas J., Ali, A.M and Lajis N.H. (2005). Atrovirisidone B, a New Prenylated Depsidone with Cytotoxic Property from the Roots of Garcinia atroviridis. Z. Naturforsch. 60c: 523-526. [IF = 0.776]; citations – 14; Quartile ranking: Q4. 67. Missailidis S., Stanslas J., Modi C., Ellis M.J., Robins R.A., Laughton C.A., Stevens M.F. (2002). Antitumor polycyclic acridines.Part 12. Physical and biological properties of 8,13-diethyl-6-methylquino[4,3,2-kl]acridinium iodide: a lead compound in anticancer drug design. Oncology Research, 13(3):175-189. [IF = 1.193]; citations – 12; Quartile ranking: Q4. 68. Abdul Wahab K., Stanslas J., Abu Bakar A., Promwichit P., Aziz S, Marzuki S., & Oon K.W. (2001).Cytotoxic and Antioxidant Properties of Wood Tissues of Three Malaysian Timber Species. Journal of Tropical Medicinal Plants, 2(2): 163-168; citations – 0; *CAU 69. Stanslas J., Hagan D.J., Ellis M.J., Turner C., Carmichael J., Ward W., Hammonds T.R., Stevens M.F.G. (2000). Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA-affinic tetra- and penta-cyclic acridines. Journal of Medicinal Chemistry 43: 1563-1572. [IF = 5.504]; citations – 57; Quartile ranking: Q1. 70. Hawariah A. and Stanslas J. (1998). In vitro response of human breast cancer cell lines to the growth-inhibitory effects of styrylpyrone derivative (SPD) and assessment of its antiestrogenicity. Anticancer Research, 18(6A): 4383-4386. [IF = 1.879];citations – 14; Quartile ranking: Q3. 71. Hawariah A. and Stanslas J. (1998). Antagonistic effects of styrylpyrone derivative (SPD) on 7,12-dimethylbenzanthracene-induced rat mammary tumors. In Vivo 12(4):403-410. [IF = 1.286]; citations – 16; Quartile ranking: Q3. 72. Pihie A.H., Stanslas J. and Din L.B. (1998). Non-steroid receptor-mediated antiproliferative activity of styrylpyrone derivative in human breast cancer cell lines. Anticancer Research, 18(3A):1739-1743. [IF = 1.879]; citations – 53; Quartile ranking: Q3.

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73. Noah R.M., Zauyah Y., Jais M.R., Stanslas J., Lope Pihie A.H. (1995). Modulation of macrophage function in rats treated with a styrylpyrone derivative. Science International (Lahore), 7(2): 299-30; citations – 0. 74. Zauyah Y., Noah R.M., Jais M.R., Stanslas J., Lope Pihie, A.H. (1995). Effect of a styrylpyrone derivative on rat lymphoid cells. Science International (Lahore), 7(3): 373-375; citations – 0.

#CA – corresponding author

*CAU – corresponding author from UPM

IF - 5-year impact Factor

Scopus

H-Index: 15

Total citations: 796

Google Scholar

H-Index: 17

i10-Index: 29

Citations: 1084

b. Non-cited Journal 1. Zauyah Y., Lope Pihie, A.H., Noah R.M., Stanslas J. (1997). Cytotoxicity of goniothalamin on hormone-dependent breast cancer cells. Malaysian Journal of Biochemistry and Molecular Biology, 2: 29-32. 2. Jada S.R., McCarroll A., Mathews C., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F and Stanslas J. (2005). Semisynthesis of Andrographolide Analogues and Evaluation of Their Anticancer Properties. Bioscientist, 3(2):18. 3. Jada S.R., Matthews C., Saad M.S., Hamzah A.S, Lajis N.H., Stanslas J. (2010). Andrographolide Derivatives Suppress the Growth of Cancer Cells. Synthesis, 28: 7. 4. Stanslas J. Translational Research and Drug Discovery for Cancer Treatment (2012). Greater Kuala Lumpur. 165 (ISBN 978-3-932831-42-3), KVB Publishing House, Munich, Germany.

Editorial Board Member

11

World Journal of Pharmacology

WebMedCentral Pharmacology

ISRN Pharmacology

Journal Reviewer

Journal of Pharmacology and Experimental Therapeutics (JPET)

European Journal of Pharmacology

British Journal of Pharmacology

Clinical and Experimental Pharmacology and Physiology

Journal of Pharmacy and Pharmacology

Scientific Reports

Investigational New Drug

Anticancer drugs

PLOS One

Pharmaceutical Biology

Yonsei Medical Journal

Iranian Journal of Pharmacology and Therapeutics

Journal of Ethnopharmacology

Journal of Natural Products

Planta Medica

Phytochemistry

Process Biochemistry

Biochimie

Molecular and Cellular Endocrinology

Letters in Drug Design & Discovery

Medicinal Chemistry

Redox report

Journal of Cancer Research and Experimental Oncology

Malaysian Journal of Medicine and Health Sciences

Malaysian Journal of Medicine

Grant Reviewer

University of Kuwait

Ministry of Science, Technology and Innovation, Malaysia (Sciencefund and Technofund – Biopharmacy and Science & Technology)

Ministry of Agriculture, Malaysia

12

Institute of Medical Research, Ministry of Health, Malaysia Proceeding(s) Local 1. Siti Selina AH, Fauziah O, Ghrissi M, Azmi M and Stanslas J. Gene therapy of VP in human breast cancer cell line (MCF-7): A TEM study. (1999). Electron Microscopy Society of Malaysia: Proc 8th Scient Conference, 133-134. 2. Azimahtol H.L.P., Stanslas J. (1994). Compound H: a natural anti-breast cancer agent. Proc.Of COSTAM. 3. Zauyah Y., Azimahtol H.L.P., Stanslas J. (1994). Synergistic antiproliferative effect of goniothalamin and tamoxifen on MCF-7 cells. Proc. Academy of Science Malaysia, KL, Malaysia. 4. Azimahtol H.L.P., Stanslas J., Ramli M.F., Laily D. (1994). Pharmacodynamics of a styrylpyrone derivative. Proc. Malaysian Biochem. Soc. Conf. 5. Asmawati D., Stanslas J., Azimatol H.L.P. (1994). Effect of strylpyrone derivative as a potential antitumor agent on physiological factors of rats. Proc. Malaysian Biochem Soc Conf.. 6. Stanslas J., Azimahtol H.L.P. A preliminary study to evaluate the antitumour activity of goniothalamin in DMBA-induced rat mammary tumor model. (1993). Proc. 2nd IRPA-UKM Workshop: 851-854. 7. Stanslas J., Azimahtol H.L.P. (1992). Goniothalamin: a naturally occurring antiprogestagenic agent devoid of estrogenic and antiestrogenic activities in immature rat uterus. Proc. Malaysian Biochem. Soc. Conf. 17: 113-119. 8. Stanslas J., Azimahtol H.L.P., Laily D. (1991). Effect of goniothalamin on breast cancer cell lines. Proc. 4th. Natl. Biol. Sym. (Malaysia). 10. Azimahtol H.L.P., Stanslas J., Devraj, T., Manimaran S., Laily D. The potential of Goniothalamus extracts as antitumor agents. (1992). Proc. Malaysian Biochem. Soc. Conf. 17: 1-9. 11. Azimahtol H.L.P., Stanslas J., Hamid A., Laily D. (1991). Immunocytochemical evidence for the uptake of Goniothalamus extracts by estrogen receptor positive tissues. 4thNatl. Mol. Sem.And 2nd Scientific Meeting of Malaysian Soc.Of Molecular and Cellular Biology, 47.

International

1. Bostock-Smith C.E., Stanslas J., Gimenez-Arnau E., Missailidis S., Laughton C.A., Searle M.S., Stevens

M.F. (1999).Non-covalent encounters between DNA and a new pentacyclic heteroaromatic salt and the

biological sequelae. Proceedings of the American Association of Cancer Research 40.

13

2. Zauyah Y., Stanslas J., Azimahtol H.L.P. A comparative study of the effect of goniothalamin and

tamoxifen on three breast cancer cell lines. (1993). 10th Ann. Sem. and UNESCO Reg. Workshop on the

Bioassay Guided Isolation of Natural products, 31 (Abs).

3. Azimahtol H.L.P., Stanslas J., Hamid A., Laily D. (1992). .Antiprogesterone and antiestrogenic effects

of goniothalamin on estrogen target tissues. 7thAsian Symposium on Medicinal Plants, Species and

Other Natural Products (ASOMPS VII) MP-17 (Abs).

4. Azimahtol H.L.P., Stanslas J., Laily D. (1991). Anti-implantation effect of goniothalamin from

Goniothalamus tapis. 6thSoutheast Asian Pacific Regional Meeting of Pharmacologists 4218:132.

Seminar Papers Presented (oral)

International

1. Yong, A., Lajis N., Shaari K., Saad S., Stanslas J. (2011). Anticancer potential of standardised

Andrographis paniculata extract in prostate cancer models. International Conference on Natural

Products (ICNP, 2011), 14 – 16 November 2011, Palm Garden Hotel, IOI Resort Putrajaya, Malaysia.

(Oral presentation)

2. Yong A., Shaari K., Lajis N, Saad S., and Stanslas J. (2005). Stability of Bioactive Diterpenoid Lactones in

Andrographis paniculata Nees .Inaugural International Congress on Complementary and Alternative

Medicine (ICCAM), 26-28 February, Singapore (Abs pg 58, Oral presentation).

3. Stanslas J., Marsh K.L., Austin C.A., Robins R.A., Price M.R and Stevens M.F.G. Novel polycyclic

acridines as topoisomerase II inhibitors. (1997). The 8th Conference on DNA Topoisomerases in Therapy

(Amsterdam, Netherlands), 10 (Abs.) (oral presentation).

4. Schwalbe C.H., Bache C.J., Rathbone D. L., Sagineedu S.R., Jada S.R., Stanslas J., Stevens M.F.G. (2006).

Effect of Blocking Groups on the Confirmation and Intermolecular Interactions of Andrographolide.The

2006 Meeting of the American Crystallographic Association, 22-27 July 2006, Honolulu, Hawaii (Abs

W0329, Oral Presentation).

5. Umar-Tsafe N., Stanslas J., Din L.B., Ali A.M. (2000). Apoptosis-inducing potential of goniothalamin in

human leukaemia cells. The 16th Meeting of the European Association of Cancer Research (EACR),

Halkidiki, Greece (Oral – MS38).

Local 1. Jabir R.S., Ho G.W., Azrif A.A., Stanslas J. (2012). Association of side effects and single nucleotide polymorphism of genes involved in mwtabolism and transport of Docetaxel in Breast Cancer Patients. Annual Scientific Congress of Malaysian Oncological Society 2012, 6th – 9th September, Melaka.

14

2. Wong M.S., Sagineedu S.R., Khalivulla S.K., Lajis N.H., Sidik S., Mahmud R., Stanslas J. (2009). New Semisynthetic Compounds in the Treatment of Invasive and Metastatic Cancers. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 36, Oral Presentation). 3. Jabir R.S., Toe A.A., Annuar M.A.A., Stanslas J. (2009). Antiangiogenic Therapy in Cancer: Promises and Realities. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 39, Oral Presentation). 4. Zakaria S.M., Maulidiani., Khamis S., Shaaru K., Lajis N.H., Tang S.C., Lim S.H., Stanslas J. (2009). Comparison of Cytotoxic Properties of Randomly Collected Plants From Different Localities: A Malaysian Case Study. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 45, Oral Presentation). 5. Hassan N.H., Lim S.M., Stanslas J, Lim S.H. (2006). Antitumour Activity of SRJ13, a New Semisynthetic Derivative of Andrographolide in Breast Cancer Cell Lines. Proceedings of the 6th Malaysian Pharmaceutical Society Pharmacy Scientific Conference 2006, Crown Princess Hotel Kuala Lumpur, 8th – 10th September 2006. 6. Wijayahadi, N., Haron, M.R., Stanslas, J and Yusuf, Z. (2004). Immune Cell Changes in Primary Breast Cancer Patients Undergoing Chemotherapy with FEC Regimens.9th National Conference on Medical Sciences, USM, Kubang Kerian. (Abs pg 86, Oral Presentation). 7. Rozida, M.K., Lajis, N.H.L., Khozirah, S and Stanslas, J. (2004).Isolation of Bioactive Compounds from Garcinia urophylla.20th Annual Seminar of the Malaysian Natural Products Society (Abs pg 28, Oral Presentation). 8. Muthukumaran T., Stanslas J., Hany Ariffin Lim S.M., Sabariah A.R., Veera Sekaran N., Lin H.P. (2002). Paediatric secondary acute lymphoblastic leukaemia: A case study based on in vitro chemosensitivity assay. The 4th Malaysian National Haematology Scientific Meeting, Penang, Malaysia (Oral presentation).

Other Presentation (Poster/Product/Exhibition/Showcase) International 1. Jabir R.S., Ho G.F., Azrif M., Stanslas J. (2014). Vomiting in docetaxel chemotherapy: which to blame, dose or gene? The Faseb Journal, Experimental Biology, 26th-30th April San Diego Convention Centre. Meeting Abstract Supplement, (FASEB J, 28,1 (655.4)). 2. Stanslas J., Wong C.C., Periasamy N., Sagineedu S.R., Sidik S.M., Sumon S.H., Phillips R., Lajis N.H. (2014). In vitro 3D evaluation of penetrability of SRJ09, a semisynthetic anticancer agent. The Faseb Journal, Experimental Biology, 26th-30th April San Diego Convention Centre. Meeting Abstract Supplement (FASEB J, 28,1 (1048.4)).

15

3. Sani D., Ramli N., Kirby B., Sumon S., Basri H., Stanslas J. (2014). Andrographolide downregulates pro-inflammatory cytokines and free radical productions to prevent dopaminergic neuro-degeneration induced by lipopolysaccharide. The Faseb Journal, Experimental Biology, 26th-30th April San Diego Convention Centre. Meeting Abstract Supplement (FASEB J, 28,1 (1143.16)) 4. Jabir R.S., Ho G.F., Azrif M., Stanslas J. (2014). Docetaxel-induced mucositis in breast cancer patients: Association with plasma alpha-1-acid glycoprotein level and SLCO1B3 genotype. American Association of Cancer Research (AACR) annual meeting, 5th-9th April San Diego Convention Centre. (Abstract no. 5563). 5. Stanslas J., Wong C.C., Sagineedu S.R., Sidik S.M., Sumon S.H., Phillips R., Lajis N.H. (2014). SRJ09, a semisynthetic anticancer agent, targets Ras-MAPK signaling pathway: assessment in breast and colon cancer cell lines. American Association of Cancer Research (AACR) annual meeting, 5th-9th April San Diego Convention Centre. (Abstract no. 4454) 6. Chong P.L., Jaafar H.Z.., Stanslas J., Ibrahim M.H. (2013). Total phenolic content and antioxidant activity of Labisia pumila Blume cultivated under nitrogen and potassium fertilization. 5th Global Summit on Medicinal and Aromatic Plants, 8th-12th December, Miri, Sarawak, Malaysia. 7. Stanslas J., Wong C.C., Sagineedu S.R., Sidik S., Summon S.H., Philips R., Lajis N.H. (2013). Mechanism of resistance to a semisynthetic anticancer andrographolide derivative: Possible involvement of Ras-MAPK signaling pathway. Molecular Targets and Cancer Therapeutics, 19th – 23rd October, Hynes Convention Center, Boston, MA, United States. Meeting Abstract Supplement (Abs C147, pg 378) 8. Jabir S., Ho G.F., Ahmad Annuar M.A., Stanslas J. (2013). Single nucleotide polymorphisms of ABCB1, SLCO1B3, and CYP3A5: Potential biomarkers of docetaxel adverse effects in Malaysian breast cancer patients. Molecular Targets and Cancer Therapeutics, 19th – 23rd October, Hynes Convention Center, Boston, MA, United States. Meeting Abstract Supplement (Abs A210, pg 184) 9. Wong H.C., Sagineedu S.R., Loke S.C., Lajis N.H., Stanslas J. (2012). SRJ23, a potent inducer of cell cycle arrest and apoptosis in prostate cancer cells. Experimental Biology 2012, 21st – 25th April, San Diego, California, United States. Poster presentation, Meeting Abstract Supplement, 851.9 (FASEB J, 26 (851.9)). 10. Wong H.C., Sagineedu S.R., Lajis N.H. and Stanslas J. (2010).SRJ23, A new investigational anti-prostate cancer agent. Experimental Biology 2010, 24th-28th April, Anaheim, California, United States. Poster presentation, Meeting Abstract Supplement, 964.6 (FASEB J, 24 (964.6)). 11. Stanslas J., Lim S.H., Wong C.C., Sagineedu S.R. and Lajis N.H. (2010). Andrographolide as a template in the synthesis of new anticancer agents with potentially novel molecular targets. Experimental Biology 2010, 24th-28th April, Anaheim, California, United States.Poster presentation, Meeting Abstract Supplement, 773.2 (FASEB J, 24 (773.2)). 12. Jabir R.S., Naidu R., Azrif M and Stanslas J. (2010). Efficacy versus toxicity of docetaxel in Asian and Caucasian cancer patients from the pharmacogenomics perspectives: a review of the literature. Experimental Biology 2010, 24th-28th April, Anaheim, California, United States.Poster presentation, Meeting Abstract Supplement, 964.15 (FASEB J, 24 (964.1)).

16

13. Wong C.C., Sagineedu S.R., Lajis N.H., Stanslas J. (2010). Two Semisynthetic Anticancer Lead Compounds: Assessment of In Vitro Activities against Breast and Colon Cancers. Recent Development in Chinese Herbal Medicine (RDCHM), 25th – 26th January, Nanyang Technological University Singapore (Abs pg 78, Poster presentation). 14. Wong H.C., Sagineedu S.R., Lajis N.H, Stanslas J. (2010). A New Semisynthetic Compound Derived from Andrographolide Displays Impressive In Vitro Activity Against Prostate Cancer Cells. Recent Development in Chinese Herbal Medicine (RDCHM), 25th – 26th January, Nanyang Technological University Singapore (Abs pg 79, Poster presentation). 15. Stanslas J., Bagalkotkar G., Tang S.C., Hamzah A.S., Shaari K., Lajis N.H., Saad, M.S. (2008). New clerodane diterpenes from Casearia capitellata as potential antitumour agents.20th EORTC - NCI - AACR Symposium on “Molecular Targets and Cancer Therapeutics”, Geneva, Switzerland, 21 - 24 October (Poster presentation, European Journal of Cancer Supplements, Volume 6, Issue 12, October 2008, Pages 58)European Journal of Cancer (Suppl) 132, p 43. 16. Stanslas J., Lim S.H., Jada S.R., Sagineedu S.R., Lajis N.H., Stevens M.F. (2008). SRJ09, a lead compound in anticancer drug design: in vitro, in vivo and mechanistic studies. 20th EORTC - NCI - AACR Symposium on “Molecular Targets and Cancer Therapeutics”, Geneva, Switzerland, 21 - 24 October (Poster presentation, European Journal of Cancer Supplements, Volume 6, Issue 12, October 2008, Pages 43). 17. Stanslas J., Bagalkotkar G., Tang S.C., Hamzah A.S., Shaari K., Lajis N.H., Saad M.S. (2008). New antitumour agents from Phyllanthus pulcher, a tropical medicinal plant. 20th EORTC - NCI - AACR Symposium on“Molecular Targets and Cancer Therapeutics”, Geneva, Switzerland, 21 - 24 October (Posterpresentation, European Journal of Cancer Supplements, Volume 6, Issue 12, October 2008, Pages 58-59). 18. Stanslas J (2006). Discovery and Development of Natural and Synthetic Anticancer Agents. International Conference: Exploring New Frontiers in Medicine and Health. 1-2 August 2006, PWTC, Kuala Lumpur (Abs S6.1 pg 50, Invited Speaker). 19. Lim S.M., Stanslas J and Ariffin H. (2006). A case study of precursor B-cell ALL with BCR-ABL fusion gene showed chemoresistance in vitro. The 10th International Symposium On Oncology Pharmacy Practice, 3-6 April 2006, Kuala Lumpur (Abs pg 76, Poster Presentation). 20. Jada S.R., Sageneedu S.R., Hamzah A.S., Stanslas J., Stevens MFG, Chowbay B. (2005). Structure Activity Relationship and Antitumour Activities of Andrographolide and its Novel Derivatives. Annals Academy of Medicine NHG & SingHealth (Poster Abstracts). BAS 176, pg S70. 21. Jada S.R., Mathews C., Stevens M.F and Stanslas J. (2005). Mechanisms of Antitumour Activities of Andrographolide Derivatives. United Kingdom National Cancer Research Institute (NCRI) Cancer Conference, 2-5 October, Birmingham (Abs pg 15, Poster Presentation). 22. Wijayahadi N., Yusuf Z., Stanslas J., and Haron M.R. (2005). Comparison of Side Effects of Chemotherapy Regimens with Epirubicin and Doxorubicin on Profiles of Immune Cells of Breast Cancer

17

Patients. United Kingdom National Cancer Research Institute (NCRI) Cancer Conference, 2-5 October, Birmingham (Abs pg 17, Poster Presentation). 23. Wijayahadi N., Yusuf Z., Haron M.R and Stanslas J. (2005).CD28 Expression on Lymphocytes of Breast Cancer Patients Undergoing Chemotherapy. United Kingdom National Cancer Research Institute (NCRI) Cancer Conference, 2-5 October, Birmingham (Abs pg 18, Poster Presentation). 24. Jada S.R., McCarroll A., Mathews C., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F., and Stanslas J. (2005). Semisynthesis of Antitumour Andrographolide Derivatives. United Kingdom National Cancer Research Institute (NCRI) Cancer Conference, 2-5 October, Birmingham (Abs pg 60, Poster Presentation). 25. Ali Abdalla J., Yong A., Abdul Kadir M., Stanslas J., and Saad M. S. (2005).Molecular and Phytochemical Variability of Andrographis paniculata Germplasms in Malaysia. Inaugural International Congress on Complementary and Alternative Medicine (ICCAM), 26-28 February, Singapore (Abs pg 116, poster presentation). 26. Jada S. R., Stanslas J., Lajis N.H., Saad S., Hamzah A.S., McCorroll A., Mathews C and Stevens M.F.G. (2003). APAG-1 derivatives as antitumour agents. British Cancer Meeting, 2-5 July, Bournemouth, UK (poster presentation). 27. Stanslas J., Yahaya R.N.R and Jada S.R. (2003).Inhibition of proteasome function as a mechanism of antitumour activities of naturally occurring lactone ring-based compounds and their synthetic derivatives. British Cancer Meeting, 2-5 July, Bournemouth, UK (poster presentation). 28. Stanslas J., Manikam S.D and Holme A. (2003). Induction of differentiation and apoptosis by APAG-1 in acute promyelocytic leukaemia cells. British Cancer Meeting, 2-5 July, Bournemouth, UK (poster presentation). 29. Stanslas J., Liew P.S., Iftikhar N., Lee C.P., Saad S., Lajis N., Robins R.A., Loadman P., Bibby M.C. (2001). Potential of AG in the treatment of breast cancer. 11th European Cancer Conference (ECCO), Lisbon, Portugal (poster presentation). 30. Stanslas J., Marsh K.L., Austin C.A., Robins R.A., Price M.R., Double J.A., Stevens MFG. Topoisomerase II inhibiting antitumour polycyclic acridines. (2000). The 16th Meeting of the European Association of Cancer Research (EACR), Halkidiki, Greece (poster - FP51). 31. Zauyah Y., Stanslas J., Noah R.M., Jais M.R., Lope Pihie A.H. (2000). Stimulation of the immune system as a mechanism of tumour prevention by goniothalamin. The 16th Meeting of the European Association of Cancer Research (EACR), Halkidiki, Greece (Poster – FP50). 32. Hagan D.J., Stanslas J., Ellis M.E., Missailidis S., Arnau E.G., Double J.A., Stevens M.F.G. (1998). New DNA interactive aza-polycyclic compounds: Physical and biological properties. Annals of Oncology 9 No.S2, p.135. 33. Stanslas J., Marsh K.L., Austin C.A., Robins R.A., Price M.R., Double J.A., Stevens M.F.G. (1998). Antitumour properties of novel aza-polycyclic compounds. British Journal of Cancer, 78, No.S1, p.P32.

18

34. Arnau E.G., Missailidis S., Hagan D.J., Stanslas J., Stevens M.F.G. (1997).Studies on the interactions between DNA and novel polycyclic acridine derivatives. British Journal of Cancer, 75, P7, 20. 35. Zauyah Y., Stanslas J., Azimahtol H.L.P. (1993) A comparative study of the effect of goniothalamin and tamoxifen on three breast cancer cell lines. 10th Ann. Sem. and UNESCO Reg. Workshop on the Bioassay Guided Isolation of Natural products, 31 (Abs). 36. Azimahtol H.L.P., Stanslas J., Hamid A., Laily D. (1992). Antiprogesterone and antiestrogenic effects of goniothalamin on estrogen target tissues. 7thAsian Symposium on Medicinal Plants, Species and Other Natural Products (ASOMPS VII) MP-17 (Abs).

Local

1. Tan S.F., Basri M., Stanslas J., Basri H. (2013). Development of nanoemulsion loaded with valproic acid with response surface methodology. 26th Regional Symposium Malaysia Analytical Sciences, 4th – 5th December, Kuching (Abs pg 4). 2. Tan S.M., Stanslas J., Karjiban R.A., Kirby B., Basri M., Basri H. (2013). The preparation and characterization of carbamazepine-encapsulated nanoemulsion targeting the brain via parental administration. 26th Regional Symposium Malaysia Analytical Sciences, 4th – 5th December, Kuching (Abs pg 24) 3. Daood G.S., Basri H., Stanslas J., Basri M. (2013). The preparation and characterization of carbamazepine-encapsulated nanoemulsion targeting the brain via parental administration. 26th Regional Symposium Malaysia Analytical Sciences, 4th – 5th December, Kuching (Abs pg 24) 4. Suppaiah V., Zareen S., Shaari K., Lajis N.H., Stanslas J. (2009). Inhibition of Leukotriene Production by Compounds and Extracts of Melicope ptelefolia: A Potential Role in the Treatment of Asthma. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 75, Poster Presentation). 5. Lim C.W., Sagineedu S.R., Khalivulla S.I., Sidik S.M., Abdul Latif A.H.D., Lajis N.H., Wong W.S.F., Stanslas J. (2009). In Vitro Cysteinyl Leukotriene Synthesis Inhibition by Natural and New Semi-synthetic Diterpenoids in Murine Macrophages: Potential for Development of New Antiasthma Agent. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 76, Posterl Presentation). 6. Ramli N., Stanslas J., Jamal J.A. (2009). Estrogenic Effect of Labisia Pumila Var Alata Extracts In Vitro. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 80, Poster Presentation).

19

7. Wong H.C., Sagineedu S.R., Khalivulla S.I., Lajis N.H., Stanslas J. (2009). SRJ23, A Promising New Anti-prostate Cancer Agent. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 97, Poster Presentation). 8. Wong C.C., Sagineedu S.R., Khalivulla S.I., Stanslas J. (2009). SRJ09 and SRS88, Two Lead Anticancer Agents: Growth Inhibition, Cell Cycle Arrest and Cell Death Induction of Breast and Colon Cancer Cells. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 99, Poster Presentation). 9. Lim S.M., Stanslas J and Ariffin H. (2005). Development of a predictive assay for treatment of childhood leukaemia. Malaysian Pharmaceutical Society Pharmacy Scientific Conference, Sunway Pyramid (Abs pg 54, Poster Presentation). 10. Jabit, M.L., Lajis, N.H.L., Khozirah, S and Stanslas, J. (2004). Bioassay-directed Isolation of Compounds from Garcinia penangiana Leaf Extract. 20th Annual Seminar of the Malaysian Natural Products Society (Abs pg 59, Poster Presentation). 11. Faridah, A, Lajis, N.H.L., Lim S. H., Syahida, A., Stanslas, J., Israf, D.A., Khozirah, S., Umi Kalsom, Y and Othman, A.G. (2004). Semisynthesis and Biological Evaluation of Curcumin Related Diarylheptanoids. 20th Annual Seminar of the Malaysian Natural Products Society (Abs pg 66, Poster Presentation). 12. Ali Abdalla J., Saad S., Stanslas J., Abdul Kadir M., Mohamed R, Yong A. (2003). Genetic variations and antitumour activity of Andrographis paniculata. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 93) (poster presentation). 13. Yong A., Chong G.H., Stanslas J., Ibrahim M.N., Lajis N., Shaari K., and Saad S. (2003). Stability Study of Bioactive Diterpenoid Lactones in Andrographis paniculata Nees. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 91) (poster presentation). 14. Saif-Ali R., Jada S.R., Stanslas J., Saad S., Lajis N., Hamzah S.H. (2003). Antitumour Activities of Synthetic Derivatives of APAG-1. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 92) (poster presentation). 15. Bagalkotkar G., Stanslas J., Lajis N., Shaari K., Saad S., Hamzah AS (2003). Cytotoxic Potential of Compounds Isolated from A Phyllanthus Sp. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 89) (poster presentation). 16. Suppaiah V., Mohd Asihin M.A., Sekawi Z., Stanslas J. (2003). In Vitro Antiviral Activity of Two Local Herbs Against Dengue Virus Type-2. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 91) (poster presentation). 17. Jabit M.L., Lajis N.H., Stanslas J. (2003). Cytotoxic activities of Malaysian Garcinia species extracts. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 73) (poster presentation).

20

Research activities

Research Grants

a) Project leader

Year Project title Source Status

2015-2016 Prophylaxis of asthma and COPD with a standardised herbal extract

NKEA Research Grant Scheme (NRGS), Ministry of Agriculture

On-going

2014-2016 Single Nucleotide Polymorphisms, Psycho-social and Nutritional Risk Factors for Major Depressive Disorder and Response to Drug Therapy

Putra Grant, Universiti Putra Malaysia

On-going

2013-2015 Blocking Signalling in Cancer Stem Cells to Eradicate Relapse in Cancer Chemotherapy

Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education of Malaysia

On-going

2012-2015 SRJ23 and Its Derivatives as New Anticancer Agents Targeting RAS-MAP

Kinase and NF-B Pathways: in vitro, in vivo, in silico and protein crystallography approaches

Research University Grant Scheme (RUGS), UPM

On-going

2012-2014 Potential of a standardised aqueous extract of a local herb as a cognition enhancer via maintenance and increased integrity of neuroplasticity: roles of anti-neuroinflammation and anti-oxidative properties

NKEA Research Grant Scheme (NRGS), Ministry of Agriculture

completed

2010-2012 Pharmacogenetics of Docetaxel in Malaysian Metastatic Breast Cancer Patients

Fundamental Research Grant Scheme (FRGS), Ministry of

Completed

21

Higher Education of Malaysia

2009-2011

Molecular Mechanisms of Cell Cycle Arrest and Apoptosis Induced by Semisynthetic Diterpenoids in Cancer Cell Line

Research University Grant Scheme (RUGS), UPM

Completed

2007-2009

Formulation, Gastrointestinal Transit and Absorption from Nano-particular Dispersion of Amphotericin B

SCIENCEFUND

Completed

2008-2010

Chemical Characterization, Standardization and Biological Evaluation of Melicope ptefolia Towards Their Development into Antiinflammatory Nutraceutical Products

Biopharmacy (National Pharmaceutical Institute) (MOSTI):

Completed

2007-2009

Evaluation of New Andrographolide Derivatives for Inhibitory Activities Against Tumour Vasculature and Metastasis

SCIENCEFUND CYCLE 1/2006:

Completed

2001-2002

Mammogram Imaging in the Diagnosis of Breast Cancer (University Malaya Medical Centre - UPM)

Faculty’s Students’ Project Fund

Completed

2001-2003

In vitro Assessment of the Efficacy of Standard Chemotherapeutic Drugs used in the Treatment of Childhood Leukaemia at the University Malaya Medical Centre (UMMC-UPM)

Faculty’s Students’ Project Fund

Completed

2003-2006 Synthesis of andrographolide derivatives and evaluation of their antitumour potential

UPM-IRPA EA RM8

Completed

2002-2005 Stability of bioactive diterpenoid lactones in A. paniculata’.

IRPA-PR_BTK IMR_RM8

Completed

2000-2003 Evaluation of the antitumour potential of compounds of Andrographis paniculata (andrographolide, neoandrographolide, andrographiside)

UPM-IRPA EA-RM7

Completed

22

1999-2000 New lecturer research scheme (two)

UPM

Completed

b) Co-researcher

Year Project title Project

leader

Source Status

2015-2016 Investigating the

role of anti-

inflammatory

property of natural

compounds and

their derivatives in

the treatment of

psoriasis: in vitro

studies

Dr Audrey

Yong Chee

Hui

MAHSA

University

On-going

2014-2015 Medicinal

Properties,

Nutritional Values

and Safety Profiles

of Edible Bird’s

Nest

Prof Madya

Christopher

Lim

CoE Swiftlet

Grant

On-going

2011 – 2013 Standardisation of

aqueous extract of

a local medicinal

herb based on the

anti-gout and anti-

inflammatory

activities

Prof Madya

Dr Jamia

Azdina Jamal

NKEA

Research

Grant Scheme

(NRGS),

Ministry of

Agriculture

Completed

2011 – 2013 Biosynthesis of

acylated quercetin

analogues and

evaluation of their

anticancer

Dr Choo Wee

Sim

Sciencefund Completed

23

activities

2011 – 2013 NMR-based

metabolomics

fingerprinting and

profiling of Labisia

Pumila varities and

biofluids (animal

metabolic study) in

the detection of

biomarker in

diabetic induced

rats

Prof Madya

Hawa Jaafar

NKEA

Research

Grant Scheme

(NRGS),

Ministry of

Agriculture

Completed

2011 - 2012 HPLC method

development and

validation of

determination of a

pharmaceutical

agent in mice

plasma

Dr. Audrey

Yong

SEGi

University

College

Research Fund

Completed

2010 - 2013 Development of Andrographolide and its Derivatives for the Treatment of Allergic Asthma and Asthma Exacerbation

Assoc Prof Dr

Fred Wong

Biomedical Research Council (BMRC), Singapore

Completed

2007 – 2009 Production of Coenzyme Q10 with Improved Bioavailability for Food Supplement from Tobacco Leaves

Assoc Prof Lai

Oi Meng

Techofund (MOSTI)

Completed

2007 – 2009

Anti-inflammatory and and Oestrogenic Effects of Compounds isolated from

Assoc Prof Dr Jamia Azlina Jamal

Sciencefund Cycle 1: 2006

Completed

24

Labisia spp (MYRSINACEAE)

2005 –2007

Investigation into Gene Expression and Metabonomic Profiling of Endometrial Cancer using Transgenic Animal Model

Dr Mohd Nazil Salleh

Scientific Advancement Grant Allocation (SAGA) Fund

Complete

2000-2005 Isolation and characterisation of antitumour agents from Phyllanthus pulcher

Assoc Prof Dr Said Saad

UPM-IRPA EA RM8

Complete

Patent Filed

Patent title: Cysteinyl Leukotriene Inhibitor Comprising 2,4,6-trihydroxygeranylacetophenone (tHGA) as an Active Ingredient (PI201000968)

Patent holder: Khozirah Shaari, Johnson Stanslas, Velan Suppaiah, Seema Zareen, Faridah Abas, Daud Ahmad Ishraf, Nordin Haji Lajis

Consultation activities

(a) Lead project consultant

No. Name of Consultant(s)

Name of Project/Program

Year Status (Completed/On-

going)

1 Autoimmune Sdn Bhd

To evaluate the anticancer potential of botanical extracts and antihepatotoxic effect of HepatTM

June 2004 – May 2005

Completed

2 Country Heights Health

Provide advice on the purchase and

July 2005 – June 2006

Completed

25

Sanctuary (CHHS), Palace of Golden Horses, Seri Kembangan, Serdang

running of diagnostics and health screening equipment at CHHS

3 Arah Mashur Sdn Bhd

Assessment of in vitro anticancer potential of AM botanical extracts

January 2006 – March 2006

Completed

(b) Co-project consultant

No Company Project title Duration

1 Black Gold Sdn Bhd Production of Coenzyme Q10 With Improved Bioavailabity for Food Supplement from Tobacco Leaves

September 2007 – August 2009

Extension and other public services

No. Name of Activity/Project/

Program

Organiser Place Date

1 Anugerah Tidak Ternilai – Anugerah Herba

RTM TV1 Malaysia November 2004

Awards

International

1. International Invention, Innovation and Technology Exhibition (ITEX) - 15-17 Mei 2009 (KLCC) ‘SRJ09, A Lead Compound in Anticancer Drug Discovery’ - Bronze medal

2. 2nd place for Best Poster presentation for Division of Drug Discovery, Development and Regulatory Affairs (American Society for Pharmacology and Experimental Therapeutics), Experimental Biology 2012, 21st – 25th April, San Diego, California, United States

26

National

1. Best Poster Presentation ‘In vitro cysteinyl leukotriene synthesis inhibition in murine macrophage by natural and new semi-synthetic diterpenoids: potential for development new anti asthma agent’ - 23rd Malaysian Society of Pharmacology and Physiology Scientific Meeting, Kuala Lumpur, 12th – 13th May 2009.

2. Best Poster for Pharmaceutical Chemistry/Traditional and Complementary Medicine/Basis of Therapeutics/Pharmacology - 6th Malaysian Pharmaceutical Society Pharmacy Scientific Conference 2006, Crown Princess Hotel Kuala Lumpur, 8th – 10th September 2006.

3. 2nd place for Best Presenter at the Annual Scientific Congress of Malaysian Oncological Society (ASCOMOS) 2012, Melaka, Malaysia

University

Universiti Putra Malaysia research awards 2009 – 2 gold medals

1. Inhibition of Leukotriene Production by Compounds and Extracts of Melicope Ptelefolia: Potential Role in the Treatment of Asthma

2. SRJ23, A Promising New Anti-Prostate Cancer Agent

Universiti Putra Malaysia research awards 2007 – 2 gold, 3 silver and 1 bronze medals

Gold

1. SRJ09, A Lead Compound In Anticancer Drug Design

2. Inhibition of Tumour Growth Through Suppression of Angiogenesis By a natural compound.

Silver

1. Therapeutic Potential of Standardised AndroPan for the Treatment of Prostate Cancer.

2. Design And Synthesis Of Andrographolides As Potential Anticancer Agents: Discovery Of Cytotoxic And

Antiangiogenic Agents.

3. Isolation of New Clerodane Diterpenes From Casearia capitellata As Potential Antitumour Agents.

Bronze

1. Structure Elucidation and Antitumoural Properties Of New Terpenoid Derivatives From Phyllanthus

pulcher

Universiti Putra Malaysia research awards 2005 - 3 bronze medals

27

1. Pharmacokinetic and Antitumour Studies of Diterpenoid Lactones of Andrographis paniculata Nees – Institute of Bioscience.

2. HTLV-1 Tax Gene in Adult Leukaemia and Lymphoma Cells and In Vitro Chemosensitivity Profiles – Faculty of Medicine and Health Sciences

3. Anti-Dengue Compounds from Thottea sp - Faculty of Medicine and Health Sciences

Universiti Putra Malaysia research awards 2004

Gold Medal

Title: Semisynthesis of Antitumour Andrographolide Derivatives

2. Silver Medal

Title: Mechanisms of antitumour activities of andrographolide derivatives

3. Bronze Medal

Title: Suitable Drying and Storage Conditions to Maintain the Stability of Andrographolide in Andrograhis paniculata Nees

Excellence Service Award, Universiti Putra Malaysia: 2004 dan 2010

Administrative duties and other relevant appointment

No. Position Department/Faculty/Other Institution Year

1 Head of

Pharmacotherapeutics Unit

Department of Medicine, Faculty of

Medicine and Health Sciences, UPM

2008 – present

2 Course coordinator (General

and Biochemical

Pharmacology)

Department of Medicine, Faculty of

Medicine and Health Sciences, UPM

2010 –present

3 Course coordinator

(Molecular Pharmacology)

Department of Medicine, Faculty of

Medicine and Health Sciences, UPM

2004 – present

4 Course coordinator

(Molecular Medicine)

Department of Medicine, Faculty of

Medicine and Health Sciences, UPM

2004 – 2006

Academic duties/committee members

28

No. Title Level (International/National/University/Faculty/Department)

Year

1 Member of the Faculty’s Preclinical Curriculum Committee

Faculty of Medicine and Health Sciences, UPM 2005

2 Member of the Faculty’s Continual Medical Education (CME) Committee

Faculty of Medicine and Health Sciences, UPM 2003 – 2004

3 Advisor to The Putra Medical Club

Faculty of Medicine and Health Sciences, UPM 2003 – 2004

4 Member of the Faculty’s Support Staff Committee

Faculty of Medicine and Health Sciences, UPM 2002 – 2003

5 Member of the Medical Research Ethical Committee

Faculty of Medicine and Health Sciences, UPM 2008 – present

6 Member of the Laboratory Committee

Faculty of Medicine and Health Sciences, UPM 2008 – present

7 Member of the Animal Care and Use Committee

Faculty of Medicine and Health Sciences, UPM 2009 - 2012

8 Research Associate at the Natural Products Laboratory

Institute of Bioscience, UPM 2001 – present

9 Grant reviewer (RUGS, FRGS, ERGS, PRGS)

Universiti Putra Malaysia 2011 – 2014

10 Technical reviewer

Universiti Malaya 2012

11 Project reviewer

University of Kuwait 2011

29

12 Committee member for “Etika Universiti untuk Penyelidikan Melibatkan Manusia (JKEUPM)”

Universiti Putra Malaysia 2012

Involvement in professional association/organization/body

No. Name of Association/Organization/Body

Role (President/Secretary/Committee Member/Ordinary Member

1 National Seminar on ‘Translational Research in Oncology’

Chairperson

2 National Seminar on ‘Paediatric Neurotransmitter Diseases’

Chairperson

3 5th Malaysian Conference on Healthy Ageing

Scientific Chairman

4 2nd Annual Neuroscience Seminar Committee Member

5 International Conference on Natural Products 2011

Committee Member

6 1st World Congress on Healthy Ageing 2012

Committee Member

7 Nobel Laurate Committee of Malaysia Committee Member