Curriculum vitae Personal details: Surname: LANDEGGER First Name(s): Lukas David Academic title: Dr. med. univ. (=M.D.), Ph.D. Place of residence: Cambridge, MA, USA

Place of birth: Zell am See, Austria Date of birth: May 1, 1987 Nationality: Austrian Parents: Father: Dr. med. univ. Thomas Landegger (ENT specialist)

Mother: Dr. Mag. Angelika Landegger Education: 1993 to 1995: Primary school, Zell am See, Austria 1995 to 1997: Primary school, St. Johann in Tirol, Austria 1997 to 2005: Grammar school, St. Johann in Tirol, where I graduated with honors. In Austria, it takes at least four years of primary school and eight years of secondary school to go to university. 2005 to 2011: Medical studies at the Medical University of Innsbruck (“Medizinische Universität Innsbruck”). Undergraduate medical programs in Austria have a duration of at least six years. ! 2009 / 2010: Stay in Paris, France for two semesters with the ERASMUS program. ! 2010 / 2011: Medical trainings at various institutions during my final practical year. After completion of all my tests with good results, I graduated with the Austrian degree “Dr. med. univ.” (M.D.). 01-07/2012: Six months of compulsory military service with the Austrian Armed Forces at the Military Hospital 2 in Innsbruck and the “Feldambulanz“ (= smaller hospital) Salzburg. 08/2012 to 01/2018: PhD in the Neuroscience program at the Medical University of Vienna (“Medizinische Universität Wien”). ! 08/12-03/13: Start of my specialization at Dr. Peter Hallmann’s ENT office

(accepted as part of the residency) and work at the allergy center AllergyCare® (focus on in vitro allergy diagnosis with the ImmunoCAP® ISAC), both in Vienna.

! 04/13-09/13: Research associate at the inner ear laboratory of the ENT department at the General Hospital (AKH), Medical University of Vienna. Projects concerning cochlear implants and prevention/treatment of (drug-/noise-induced) hearing loss in guinea pigs.

! 10/13: Start of my research projects at the Massachusetts Eye and Ear, Harvard Medical School, Boston, USA.

Practical experience prior to my specialization in ENT: From 2003 to 2012, I often worked in my father’s doctor’s office. In 2004, I performed a voluntary traineeship for four weeks in the department of

internal medicine at the hospital St. Johann in Tirol, Austria. In 2007, I did a medical training for three weeks in the department of trauma surgery

at the hospital St. Johann in Tirol, Austria. In 2008, I performed a medical training for four weeks in the department of internal

medicine at the Singapore General Hospital, National University of Singapore. I worked as a tutor for students in their second semester at the division of

biochemistry at Innsbruck Medical University in spring 2009. In summer 2009, I performed a medical training for four weeks in the department of

neurology at Concord Clinical School, University of Sydney, Australia. From September 2009 until June 2010, I spent a year in Paris, France with the

ERASMUS programme (student exchange between countries of the European Union), where I worked in different hospitals for at least six hours every day next to my courses – amongst others: Pitié-Salpêtrière, Val-de-Grâce, American Hospital, Hôtel-Dieu, Necker, Lariboisière, Cochin, Saint-Vincent de Paul...

Additionally, I wrote an article on “Correlation between HPV and HNSCC: should boys in the European Union be included in HPV vaccination?” at the department of otolaryngology at the Institut Curie (Service de chirurgie cervico-faciale et ORL).

From August 2010 until November 2010, for the first part of my final practical year, I

worked for three months in the department of internal medicine (one month each in the ward of internal medicine, the ward of infectious medicine, and consultations in internal medicine) at the Hospital Universitario de la Princesa, Autonomous University of Madrid (“Universidad Autónoma de Madrid”), Spain.

From November 2010 until February 2011, I performed a medical training for eight

weeks in general surgery at the Charité - Campus Virchow Klinikum (CVK) in Berlin, Germany.

In February / March 2011, I performed a medical training for four weeks in the

department of otolaryngology (ENT) at Innsbruck Medical University. In March / April 2011, I worked for four weeks in general medicine at the

“Ambulatorium und Praxiszentrum Augarten/Ordination Dr. Molnár” in Vienna, Austria.

In April 2011, I performed an elective for four weeks in research ophthalmology at the

Mount Sinai Hospital in New York, USA. During this stay, it was possible for me to work on five different papers with foci on dry eye disease, tear

osmolarity, and omega-3 fatty acids in relation to ophthalmologic problems and to get an insight into clinical and operative procedures as well.

In May / June 2011, I went for four weeks to Heidelberg, Germany, to gain

experience in the field of anesthesiology at the local University Clinic. In September 2011, I was one out of 50 students from other universities per year who

were given the opportunity to go to the University of Oxford, UK for a clinical rotation. During the four weeks there, I worked in the department of otolaryngology (ENT) at the John Radcliffe hospital and wrote an article on the “Effects of postpartum administration of valganciclovir on infantile hearing loss after in utero infection with the human cytomegalovirus (HCMV)“ under the supervision of Mr. James Ramsden, BA, BM BCh, FRCS, PhD.

In October 2011, I performed an elective in orthopedic surgery for four weeks at the

University Hospital in New Orleans, USA. This exchange was organized by the Austrian Medical Students’ Association (AMSA), which ranks students every year to assign placement. In this competitive program, I was the only Austrian medical student that received a place in the USA during this academic year.

In November 2011, I organized a research rotation at the Massachusetts Eye and

Ear Infirmary in Boston, USA, the primary teaching and research facility for otolaryngology and ophthalmology for Harvard Medical School. There I worked for four weeks with Michael S. Cohen, MD, from the department of otolaryngology (ENT) on projects concerning auditory neuropathy, familial congenital cholesteatoma, and enlarged vestibular aqueducts. I also attended clinical and operative procedures.

Scientific articles: Published:

1. Landegger LD, Cohen MS. Congenital cholesteatoma in siblings. J Laryngol Otol. 2013 Nov;127(11):1143-4. doi: 10.1017/S0022215113002284.

2. Honeder C, Engleder E, Schöpper H, Krause M, Landegger LD, Plasenzotti R, Gabor F, Gstoettner W, Arnoldner C. Evaluation of the Selective Glucocorticoid Receptor Agonist Compound A for Ototoxic Effects. Laryngoscope. 2015 Apr;125(4):E149-55. doi: 10.1002/lary.25011.

3. Kozin ED, Gulati S, Kaplan AB, Lehmann AE, Remenschneider AK, Landegger LD, Cohen MS, Lee DJ. Systematic review of outcomes following observational and operative endoscopic middle ear surgery. Laryngoscope. 2015 May;125(5):1205-14. doi: 10.1002/lary.25048.

4. Dilwali S, Kao SY, Fujita T, Landegger LD, Stankovic KM. Non-steroidal Anti-inflammatory Medications are Cytostatic Against Human Vestibular Schwannomas. Transl Res. 2015 Jul;166(1):1-11. doi: 10.1016/j.trsl.2014.12.007.

5. Honeder C, Landegger LD, Engleder E, Gabor F, Plasenzotti R, Plenk H, Kaider A, Hirtler L, Gstoettner W, Arnoldner C. Effects of intraoperatively applied glucocorticoid-hydrogels on residual hearing and foreign-body reaction in a guinea pig model of cochlear implantation. Acta Otolaryngol. 2015 Apr;135(4):313-9. doi: 10.3109/00016489.2014.986758.

6. Dilwali S, Briet MC, Kao SY, Fujita T, Landegger LD, Platt MP, Stankovic KM. Preclinical Validation of Anti-Nuclear Factor-kappa B Therapy to Inhibit Human Vestibular Schwannoma Growth. Mol Oncol. 2015 Aug;9(7):1359-70. doi: 10.1016/j.molonc.2015.03.009.

7. Fernandez KB, Epstein SP, Raynor GS, Sheyman AT, Massingale ML, Dentone PG, Landegger LD, Asbell PA. Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eye drop solution. Clin Ophthalmol. 2015 Jun 24;9:1137-45. doi: 10.2147/OPTH.S81355.

8. Cohen MS, Landegger LD, Kozin ED, Lee DJ. Pediatric endoscopic ear surgery in clinical practice: Lessons learned and early outcomes. Laryngoscope. 2016 Mar;126(3):732-8. doi: 10.1002/lary.25410.

9. Dilwali S*, Landegger LD*, Soares VY, Deschler DG, Stankovic KM. Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage. Sci Rep. 2015 Dec 22;5:18599. doi: 10.1038/srep18599. (* = equal contribution)

10. Landegger LD, Psaltis D, Stankovic KM. Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear. Hear Res. 2016 May;335:83-93. doi: 10.1016/j.heares.2016.02.018.

11. Landegger LD, Honeder C, Zhu C, Schöpper H, Engleder E, Gabor F, Gstoettner W, Arnoldner C. Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A. J Negat Results Biomed. 2016 May 11;15:10. doi: 10.1186/s12952-016-0053-0.

12. Soares VY, Atai NA, Fujita T, Dilwali S, Sivaraman S, Landegger LD, Hochberg FH, Oliveira CA, Bahmad F Jr, Breakefield XO, Stankovic KM. Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells. Neuro Oncol. 2016 Nov;18(11):1498-1507.

13. Landegger LD, Cohen MS. Use of the Flexible Fiber CO2 Laser in Pediatric Transcanal Endoscopic Middle Ear Surgery. Int J Pediatr Otorhinolaryngol. 2016 Jun;85:154-7. doi: 10.1016/j.ijporl.2016.03.039.

14. Honeder C, Zhu C, Schöpper H, Gausterer JC, Walter M, Landegger LD, Saidov N, Riss D, Plasenzotti R, Gabor F, Arnoldner C. Effects of sustained release dexamethasone-hydrogels in hearing preservation cochlear implantation. Hear Res. 2016 Nov;341:43-49. doi: 10.1016/j.heares.2016.08.001.

15. Jan TA, Cheng YS*, Landegger LD*, Lin BM, Srikanth P, Niesten ME, Lee DJ. Relationship between Surgically Treated Superior Canal Dehiscence Syndrome and Body Mass Index. Otolaryngol Head Neck Surg. 2017 Apr;156(4):722-727. doi: 10.1177/0194599816686563. (* = equal contribution)

16. Landegger LD*, Pan B*, Askew C*, Wassmer S, Gluck S, Galvin A, Forge A, Taylor R, Stankovic KM&, Holt JR&, Vandenberghe LH&. A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nat Biotechnol. 2017 Mar;35(3):280-284. doi: 10.1038/nbt.3781. (*/& = equal contribution)

17. Landegger LD*, Sagers JE*, Dilwali S, Fujita T, Sahin MI, Stankovic KM. A Unified Methodological Framework for Vestibular Schwannoma Research. J Vis Exp. 2017 Jun 20;(124). doi:10.3791/55827. (* = equal contribution)

18. Landegger LD, Dilwali S, Stankovic KM. Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research. J Vis Exp. 2017 Jun 8;(124). doi:10.3791/55704.

19. Sagers JE, Landegger LD, Worthington S, Nadol JB Jr., Stankovic KM. Human Cochlear Histopathology Reflects Clinical Signatures of Primary Neural Degeneration. Sci Rep. 2017 Jul 7;7(1):4884. doi: 10.1038/s41598-017-04899-9.

20. Abdul-Aziz D*, Kozin ED*, Lin BM, Wong K, Shah PV, Remenschneider AK, Landegger LD, Juliano AF, Cohen MS, Lee DJ. Temporal bone computed tomography findings associated with feasibility of endoscopic ear surgery. Am J Otolaryngol. 2017 Nov - Dec;38(6):698-703. doi: 10.1016/j.amjoto.2017.06.007. (* = equal contribution)

21. Landegger LD, Lee JD, Linthicum FH Jr., Stankovic KM. Cochlear Damage is Less Common in Cerebellopontine Angle Meningioma than Vestibular Schwannoma. Otol Neurotol. 2017 Dec;38(10):e486-e489. doi: 10.1097/MAO.0000000000001582.

22. Ren Y, Sagers JE, Landegger LD, Bhatia SN, Stankovic KM. Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas. Sci Rep. 2017 Oct 10;7(1):12922. doi: 10.1038/s41598-017-13032-9.

23. Maxfield AZ, Landegger LD, Brook CD, Lehmann AE, Campbell A, Bergmark RW, Stankovic KM, Metson R. Periostin as a Biomarker for Nasal Polyps in Chronic Rhinosinusitis. Otolaryngol Head Neck Surg. 2018 Jan;158(1):181-186. doi: 10.1177/0194599817737967.

24. Zhao Y, Liu P, Zhang N, Chen J, Landegger LD, Wu L, Zhao F, Zhao Y, Zhang Y, Zhang J, Fujita T, Stemmer-Rachamimov A, Ferraro GB, Liu H, Muzikansky A, Plotkin SR, Stankovic KM, Jain RK, Xu L. Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2077-E2084. doi: 10.1073/pnas.1719966115.

25. Sagers JE, Brown AS, Vasilijic S, M Lewis R, Sahin MI, Landegger LD, Perlis RH, Kohane IS, Welling DB, Patel CJ, Stankovic KM. Computational repositioning and preclinical validation of mifepristone for vestibular schwannoma. Sci Rep. 2018 Apr 3;8(1):5437. doi: 10.1038/s41598-018-23609-7.

26. Duarte MJ*, Kanumuri VV*, Landegger LD, Tarabichi O, Sinha S, Meng X, Hight AE, Kozin ED, Stankovic KM, Brown MC, Lee DJ. Ancestral Adeno-Associated Virus Vector Delivery of Opsins to Spiral Ganglion Neurons: Implications for Optogenetic Cochlear Implants. Mol Ther. 2018 Jun 29. pii: S1525-0016(18)30256-9. doi: 10.1016/j.ymthe.2018.05.023. [Epub ahead of print] (* = equal contribution)

Currently under review:

27. Landegger LD, Reider N. Impact of Cellular Antigen Stimulation Test (CAST) in the diagnosis of NSAID hypersensitivity. 2012-2014.

28. Chen J*, Landegger LD*, Sun Y, Ren J, Maimon N, Roberge S, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Huang P, Jain RK, Plotkin SR, Stankovic KM&, Xu L&. A cerebellopontine angle model to evaluate tumor progression and hearing function for NF2-related Vestibular Schwannoma in mice. 2015-2017. (*/& = equal contribution)

Conferences/congresses/posters/presentations (presenting author underlined):

Repeated participation in the “Innsbrucker Allergiegespräche” and the “Pirquet Clubs”, organized by Doz. Heinz Kofler in Innsbruck, Austria

Repeated participation in the “HNO-Fachgespräche”, organized by Prof. Dr. Herbert Riechelmann in Innsbruck, Austria

Repeated participation in the “HNO-Qualitätszirkel”, organized by Prim. Dr. Peter Ostertag in the districts of Kufstein and Kitzbühel, Austria

Repeated participation in the “AllergyClub” seminars, organized by Prof. Dr. Erika Jensen-Jarolim in Vienna, Austria

Participation in the “62. Tagung der ORL-Gesellschaft zu München e.V.”, organized by the heads of the ENT departments of the “Technische Universität München” and the “Ludwig-Maximilians-Universität München”, Prof. Dr. Bier and Prof. Dr. Berghaus, in December 2011 in Munich, Germany

Participation in the “7. Tiroler Allergietagung”, organized by Prof. Dr. Norbert Reider in March 2012 in Innsbruck, Austria

Presentation of the poster “Landegger LD, Cohen MS. Case report of familial congenital cholesteatoma - does genetic predisposition play a role in selected individuals?” at the 2012 Spring Meeting of the American Society of Pediatric Otolaryngology (ASPO) in April 2012 in San Diego, USA

Presentation of the oral abstract (main congress) and the poster (JMA poster session) “Landegger LD, Reider N. Impact of cellular antigen stimulation test (CAST) in the diagnosis of non-steroidal anti-inflammatory drug (NSAID) hypersensitivity” at the European Academy of Allergy and Clinical Immunology (EAACI) Congress 2012 in June 2012 in Geneva, Switzerland

Participation in the 2012 EAACI Allergy School “Food Allergy Training Course” in August 2012 in Vienna, Austria

Participation in the 56th Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology, Head & Neck Surgery in September 2012 in St. Pölten, Austria

Participation in the 3rd “Bencard Allergie Symposium” in October 2012 in Vienna, Austria

Presentation of the oral abstract “Landegger LD, Reider N. CAST ist nicht hilfreich fuer die Diagnostik der NSAR-Intoleranz” at the Annual Meeting of the Austrian Society of Dermatology and Venereology in November 2012 in Linz, Austria

Participation in the “Salzburger HNO-Gespräche” in April 2013 in Salzburg, Austria Presentation of the oral abstract “Arnoldner C, Honeder C, Landegger LD.

Glucocorticoid-Hydrogele & Selektive Agonisten im Tiermodell: Freisetzungsverhalten, Ototoxizität, funktionelle Ergebnisse im CI-Modell & histologische Untersuchungen” at the MED-EL Symposium in June 2013 in Vienna, Austria

Participation at the European Academy of Allergy and Clinical Immunology (EAACI)/World Allergy Organization (WAO) Congress 2013 in June 2013 in Milan, Italy

Presentation of the oral abstract “Landegger LD, Honeder C, Engleder E, Krause M, Gabor F, Arnoldner C. Präoperativ appliziertes Dexamethason-Hydrogel in einem Meerschweinchen-Modell für Cochlea-Implantation” at the 57th Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology, Head & Neck Surgery in September 2013 in Graz, Austria

Presentation of the oral abstract “Arnoldner C, Engleder E, Krause M, Landegger LD, Gabor F, Honeder C. Die Zukunft der Hörsturztherapie: Intratympanale Hydrogele und SEGRAs?” at the 57th Annual Meeting of the Austrian Society

of Oto-Rhino-Laryngology, Head & Neck Surgery in September 2013 in Graz, Austria

Presentation of the oral abstract “Honeder C, Engleder E, Landegger LD, Krause M, Schöpper H, Gabor F, Arnoldner C. Topische Glucocorticoid-Hydrogele: Perilymph-Konzentrationen und audiometrische Ergebnisse in einem Cochlea-Implantat-Modell” at the 57th Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology, Head & Neck Surgery in September 2013 in Graz, Austria

Participation in the 60th Annual Meeting of the Massachusetts Chapter of the American College of Surgeons in December 2013 in Boston, USA

Participation in the 2014 Bertarelli Symposium at Harvard Medical School in January 2014 in Boston, USA

Presentation of the poster “Arnoldner C, Krause M, Engleder E, Schöpper H, Landegger LD, Gabor F, Gstoettner W, Honeder C. Evaluation of the Systemic and Intratympanic Application of the Selective Glucocorticoid Receptor Agonist Compound-A for Ototoxic Effects” at the 37th Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2014 in San Diego, USA

Participation in the Austrian Research and Innovation Talk in October 2014 in Boston, USA

Presentation of the poster (* = equal contribution) “Zhu C*, Landegger LD*, Honeder C, Engleder E, Schöpper H, Gabor F, Gstoettner W, Arnoldner C. Elucidating Otoprotective Mechanisms of Steroids by Systemic Application of the Selective Glucocorticoid Receptor Agonist Compound A” at the 38th Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2015 in Baltimore, USA

Presentation of the poster and the oral abstract “Landegger LD, Psaltis D, Stankovic KM. Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear” at the 38th Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2015 in Baltimore, USA

Presentation of the poster “Landegger LD, Cohen MS. Use of the Flexible-fiber CO2 Laser in Pediatric Transcanal Endoscopic Middle Ear Surgery” at the 2015 Spring Meeting of the American Society of Pediatric Otolaryngology (ASPO) in April 2015 in Boston, USA

Presentation of the poster “Landegger LD, Shah P, Kozin ED, Lee DJ, Cohen MS. Surgical outcomes with transcanal endoscopic ear surgery in children” at the 2015 Spring Meeting of the American Society of Pediatric Otolaryngology (ASPO) in April 2015 in Boston, USA

Presentation of the poster “Honeder C, Zhu C, Gausterer JC, Schöpper H, Engleder E, Landegger LD, Walter M, Gabor F, Arnoldner C. Preoperative intratympanic glucocorticoid hydrogels: effects in a cochlear implant model” at the 52nd Inner Ear Biology Workshop in September 2015 in Rome, Italy

Presentation of the poster and the oral abstract “Landegger LD, Honeder C, Arnoldner C, Psaltis D, Stankovic KM. Humane audiometrische Schwellenwerte können spezifischen zellulären Innenohr-Schaden nicht vorhersagen” at the 59th Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology – Head and Neck Surgery in September 2015 in Innsbruck, Austria

Presentation of the poster “Landegger LD, Honeder C, Arnoldner C, Cohen MS. Einsatz des flexiblen Faser-CO2-Lasers bei transkanalen endoskopischen Mittelohreingriffen in Kindern” at the 59th Annual Meeting of the Austrian

Society of Oto-Rhino-Laryngology – Head and Neck Surgery in September 2015 in Innsbruck, Austria

Presentation of the poster and the oral abstract “Landegger LD, Shah P, Kozin ED, Honeder C, Arnoldner C, Lee DJ, Cohen MS. Chirurgische Ergebnisse transkanaler endoskopischer Mittelohroperationen in einer pädiatrischen Patientenpopulation” at the 59th Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology – Head and Neck Surgery in September 2015 in Innsbruck, Austria

Presentation of the poster “Landegger LD, Dilwali S, Soares VY, Deschler DG, Stankovic KM. Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage” at the Massachusetts General Hospital Clinical Research Day in October 2015 in Boston, USA

Participation in the Austrian Research and Innovation Talk in November 2015 in San Francisco, USA

Presentation of the poster “Landegger LD, Dilwali S, Soares VY, Deschler DG, Stankovic KM. Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage” at the 62nd Annual Meeting of the Massachusetts Chapter of the American College of Surgeons in December 2015 in Boston, USA

Presentation of the oral abstract “Landegger LD, Dilwali S, Soares VY, Deschler DG, Stankovic KM. Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage” at the 39th Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2016 in San Diego, USA

Presentation of the poster “Honeder C, Zhu C, Schöpper H, Gausterer J, Engleder E, Landegger LD, Walter M, Gabor F, Arnoldner C. Evaluation of Preoperative Dexamethasone-Hydrogel Application for Otoprotective Effects in a Cochlear Implant Model” at the 39th Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2016 in San Diego, USA

Participation in the 2016 Bertarelli Symposium at Harvard Medical School in April 2016 in Boston, USA

Presentation of the oral abstract “Landegger LD, Pan B, Wassmer S, Gluck S, Galvin A, Stankovic KM, Holt JR, Vandenberghe LH. Efficient transduction of neurosensory hair cells in the cochlea with synthetic AAV vectors” at the 19th American Society of Gene and Cell Therapy (ASGCT) Meeting in May 2016 in Washington DC, USA

Presentation of the poster “Honeder C, Landegger LD, Zhu C, Schöpper H, Engleder E, Gabor F, Gstoettner W, Arnoldner C. Noise Trauma and Systemic Application of a Selective Glucocorticoid Receptor Modulator” at the 14th International Conference on Cochlear Implants in May 2016 in Toronto, Canada

Presentation of the oral abstract “Honeder C, Zhu C, Schöpper H, Gausterer JC, Walter M, Landegger LD, Saidov N, Riss D, Plasenzotti R, Gabor F, Arnoldner C. Effects of Preoperative Dexamethasone Hydrogel Application in a Cochlear Implantation Model” at the 14th International Conference on Cochlear Implants in May 2016 in Toronto, Canada

Presentation of the poster “Landegger LD, Sahin MI, Barrett B, He M, Funk A, Faquin WC, Stankovic KM. Epidemiology of Tumors of the External Auditory Canal and Middle Ear: Experience with 2415 Pathological Samples at a Tertiary Referral Center” at the 149th American Otological Society (AOS) Meeting in May 2016 in Chicago, USA

Presentation of the poster “Zhu C, Landegger LD, Honeder C, Schöpper H, Engleder E, Gabor F, Gstoettner W, Arnoldner C. Elucidating Otoprotective Mechanisms of Steroids by Systemic Application of the Selective Glucocorticoid Receptor Agonist Compound-A: a Potential Alternative to Dexamethasone?“ at the Young Scientist Association (YSA) PhD Symposium in June 2016 in Vienna, Austria

Presentation of the oral abstract “Landegger LD, Psaltis D, Stankovic KM. Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear” at the 14th Triennial Meeting of the International Otopathology Society (Schuknecht Society) in June 2016 in Boston, USA

Presentation of the poster “Landegger LD, Sahin MI, Barrett B, He M, Funk A, Faquin WC, Stankovic KM. Epidemiologie von Tumoren des externen Gehörgangs und des Mittelohrs: Erfahrung mit 2415 pathologischen Proben an einer Universitätsklinik” at the 60th Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology – Head and Neck Surgery in September 2016 in Villach, Austria

Presentation of the poster “Landegger LD, Dilwali S, Soares VY, Deschler DG, Stankovic KM. Sezernierte Faktoren von humanen vestibulären Schwannomen können cochleären Schaden verursachen” at the 60th Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology – Head and Neck Surgery in September 2016 in Villach, Austria

Presentation of the oral abstract “Sagers JE, Landegger LD, Nadol JB, Stankovic KM. Audiometric correlates of primary auditory neuropathy: a temporal bone study.” at the Harvard-MIT Program in Speech and Hearing Bioscience and Technology End-of-Summer Symposium in September 2016 in Boston, USA

Presentation of the poster “Jan TA, Cheng YS, Niesten ME, Landegger LD, Lee DJ. Obesity and superior canal dehiscence syndrome: are they related?” at the 120th AAO-HNSF Annual Meeting & OTO EXPO in September 2016 in San Diego, USA

Presentation of the poster and the oral abstract “Landegger LD, Pan B, Askew C, Wassmer S, Gluck S, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH. Synthetic Adeno-Associated Viral Vector Enables Safe and Efficient Cochlear Gene Transfer.” at the 40th Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2017 in Baltimore, USA

Presentation of the poster (* = equal contribution) “Fujita T*, Soares VY*, Atai NA, Dilwali S, Sivaraman S, Landegger LD, Hochberg FH, Oliveira CA, Bahmad F Jr, Breakefield XO, Stankovic KM. Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells.” at the 40th Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2017 in Baltimore, USA

Presentation of the poster “Sagers JE, Landegger LD, Nadol JB, Stankovic KM. Audiometric correlates of primary auditory neuropathy: a temporal bone study.” at the 40th Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2017 in Baltimore, USA

Presentation of the oral abstract “Landegger LD, Lee JD, Aggarwal S, Linthicum FH Jr., Stankovic KM. Unlike in Vestibular Schwannoma, Cochlear Dysfunction is not Common in Meningioma of the Cerebellopontine Angle.” at the 52nd Annual Spring Meeting of the American Neurotology Society (ANS) in April 2017 in San Diego, USA

Presentation of the poster “Ren Y, Sagers JE, Landegger LD, Bhatia SN, Stankovic KM. Tumor-Penetrating Nanocomplexes for Delivery of Sirna Therapeutics to

Human Vestibular Schwannomas.” at the 150th Annual Meeting of the American Otological Society (AOS) in April 2017 in San Diego, USA

Presentation of the oral abstract (* = equal contribution) “Maxfield AZ*, Landegger LD*, Brook CD, Lehmann AE, Campbell A, Bergmark RW, Stankovic KM, Metson R. Serum Periostin as a Biomarker for Chronic Rhinosinusitis.” at the Triological Society 120th Annual Meeting in April 2017 in San Diego, USA

Presentation of the oral abstract “Kanumuri VV*, Duarte MJ*, Landegger LD, Tarabichi O, Meng X, Hight AE, Kozin ED, Stankovic KM, Brown MC, Lee DJ. Novel Approaches to Microbial Opsin Delivery for an Optogenetic based Cochlear Implant.” at the 15th Symposium on Cochlear Implants in Children (CI2017 Pediatric) of the American Cochlear Implant Alliance in July 2017 in San Francisco, USA

Presentation of the poster “Duarte M, Kanumuri VV, Landegger L, Tarabichi O, Stankovic K, Brown MC, Lee DJ. Novel vector-mediated delivery of opsins to the cochlea.” at the 121st American Academy of Otolaryngology-Head and Neck Surgery (AAO-NHSF) 2017 Annual Meeting & OTO Experience in September 2017 in Chicago, USA

Presentation of the oral abstract (* = equal contribution) “Landegger LD*, Maxfield AZ*, Brook CD, Lehmann AE, Campbell A, Bergmark RW, Stankovic KM, Metson R. Periostin als Biomarker für Polyposis nasi bei chronischer Rhinosinusitis.” at the 61st Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology – Head and Neck Surgery in September 2017 in Vienna, Austria

Presentation of the oral abstract “Landegger LD, Lee JD, Linthicum FH Jr., Stankovic KM. Cochleäre Dysfunktion in Meningeomen des inneren Gehörgangs ist selten.” at the 61st Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology – Head and Neck Surgery in September 2017 in Vienna, Austria

Presentation of the poster “Landegger LD, Duarte MJ, Kanumuri VV, Tarabichi O, Stankovic KM, Brown MC, Lee DJ. Advances in Optogenetic-based Auditory Implants.” at the Austrian Research and Innovation Talk in October 2017 in Austin, USA

Presentation of the oral abstract “Sagers JE, Brown AS, Vasilijic S, Lewis R, Sahin MI, Landegger LD, Perlis RH, Kohane IS, Welling DB, Patel CJ, Stankovic KM. Computational Repositioning and Preclinical Validation of Mifepristone for Human Vestibular Schwannoma.” at the 1st International Symposium on Inner Ear Therapies in November 2017 in Marrakech, Morocco

Presentation of the poster “Sagers JE, Brown AS, Vasilijic S, Lewis R, Sahin MI, Landegger LD, Perlis RH, Kohane IS, Welling DB, Patel CJ, Stankovic KM. Computational Repositioning and Preclinical Validation of Mifepristone for Human Vestibular Schwannoma.” at the 41st Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2018 in San Diego, USA

Presentation of the poster “Ren Y, Sagers JE, Landegger LD, Bhatia SN, Stankovic KM. Tumor-targeted Nanoparticles for Delivery of siRNA to Vestibular Schwannomas.” at the 41st Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2018 in San Diego, USA

Presentation of the poster “Zhao Y, Zhao F, Zhang N, Chen J, Landegger LD, Fujita T, Stemmer-Rachamimov A, Zhang J, Zhang Y, Ferraro G, Liu H, Muzikansky A, Liu P, Plotkin SR, Jain RK, Stankovic KM, Xu L. Targeting the

cMET pathway augments radiation response without improving hearing in NF2 schwannoma models.” at the 41st Association for Research in Otolaryngology (ARO) MidWinter Meeting in February 2018 in San Diego, USA

Participation in the 21st American Society of Gene and Cell Therapy (ASGCT) Meeting in May 2018 in Chicago, USA

Presentation of the poster “Landegger LD, Fujita T, Vasilijic S, Soares VY, Xu L, Stankovic KM. In search of secreted molecular biomarkers of noise-induced hearing loss: cytokine measurements in perilymph of young and aged mice.” at the 2018 Military Health System Research Symposium in August 2018 in Kissimmee, USA

Invited lectures Guest speaker for course 21M.380 Music and Technology: Sound Design (lecturer

Florian Hollerweger) at Massachusetts Institute of Technology (MIT) in March 2017 in Boston, USA

Guest speaker for the Auditory Neuroscience Journal Club at the Department of Otolaryngology at Ohio State University in March 2017 in Columbus, USA

Participant of the “Round Table Otologie: Neue Ergebnisse in der Grundlagenforschung und bei implantierbaren Hörsystemen” – presentation “Gentherapie in der Otologie” at the 61st Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology – Head and Neck Surgery in September 2017 in Vienna, Austria

Guest speaker for the monthly webinar of the Hearing Loss Association of America in April 2018 (https://www.youtube.com/watch?v=VXDS8pDhbE4)

Guest speaker in Professor Aaron Ciechanover and Sir Richard Timothy Hunt’s master class “Protein Dynamics in Health and Disease” during the 68th Lindau Nobel Laureate Meetings in June 2018 in Lindau, Germany (https://www.youtube.com/watch?v=nPqy03zywkg - ARD-alpha, a German educational television station followed me during the conference. Unfortunately, the video is only available in German.)

Awards/grants/nominations for programs: Erasmus grant of the European Union 2009/10 Erasmus SMP grant of the European Union 2010 Austrian Medical Students’ Association (AMSA) Standing Committee on Professional

Exchange (SCOPE) nomination 2011 Austrian Medical Students’ Association (AMSA) Standing Committee on Research

Exchange (SCORE) nomination 2011 Travel grant of the European Academy of Allergy and Clinical Immunology (EAACI)

for its congress in Geneva, Switzerland in June 2012 Junior Poster Prize at the EAACI Congress 2012 in Geneva, Switzerland in June

2012 EAACI JMA Mentorship Program nomination 2012/13 and 2013/14 – Professor

Wytske Fokkens, Department of Otolaryngology, Academic Medical Center (AMC), University of Amsterdam (“Universiteit van Amsterdam”), Amsterdam, The Netherlands

Travel grant of the Association for Research in Otolaryngology (ARO) for its 38th MidWinter Meeting in Baltimore, USA in February 2015

Heinz Kurz Poster Prize (1st place) at the 59th Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology – Head and Neck Surgery in Innsbruck, Austria in September 2015

Travel grant of the Office of Science and Technology (OST), Embassy of Austria, Washington DC for the Austrian Research and Innovation Talk in San Francisco, USA in November 2015

Meritorious Abstract Travel Award of the American Society of Gene and Cell Therapy (ASGCT) for its 19th Annual Meeting in Washington DC, USA in May 2016

Hansaton Wissenschaftspreis at the 60th Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology – Head and Neck Surgery in Villach, Austria in September 2016

Heinz Kurz Poster Prize (1st place) at the 60th Annual Meeting of the Austrian Society of Oto-Rhino-Laryngology – Head and Neck Surgery in Villach, Austria in September 2016

ASciNA Mentoring Program nomination 2016/2017 – Professor Oliver Adunka, Department of Otolaryngology, Wexner Medical Center, Ohio State University, Columbus, USA (only mentoring pair sponsored by the Alumni Club of the Medical University of Vienna in 2016/2017)

Poster Award (1st place) at the 150th Annual Meeting of the American Otological Society (AOS) in San Diego, USA in April 2017

Travel grant of the Office of Science and Technology (OST), Embassy of Austria, Washington DC for the Austrian Research and Innovation Talk in Austin, USA in October 2017

ARO-spARO Mentorship Program nomination 2017/2018 – Professor Tomoko Makishima, Department of Otolaryngology, University of Texas Medical Branch at Galveston, Galveston, USA

Best poster in basic/clinical science at the 121st American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNSF) 2017 Annual Meeting & OTO Experience in September 2017 in Chicago, USA

Austrian Marshall Plan Foundation Poster Session Award (3rd place) at the Austrian Research and Innovation Talk in October 2017 in Austin, USA

Invitation to participate in the 68th Lindau Nobel Laureate Meetings in June 2018 in Lindau, Germany

ARO-spARO Mentorship Program nomination 2018/2019 – Professor Rick F. Nelson, Department of Otolaryngology, Indiana University School of Medicine, Indianapolis, USA

Wilhelm-Auerswald-Preis (1st place) by the College of Physicians in Vienna (sponsored by Sanofi) for the best accepted dissertation at an Austrian medical university in 2017 (incl. sub-prizes for best written thesis and best presentation) – awarded in June 2018 in Vienna, Austria

Winner of the Science│Art competition 2018 (category: live visualization) of the Young Scientist Association (YSA) of the Medical University of Vienna Ad-hoc reviewer: Clinical and Translational Allergy (since 2016) Otology & Neurotology (since 2016) Allergy (since 2018) Other qualifications:

Paper for A-Levels: “Type-I allergies in ENT medicine” (German) 56 pages. 2004 / 2005

Diploma thesis: “Impact of Cellular Antigen Stimulation Test (CAST) in the diagnosis of NSAID hypersensitivity” 100 pages. 2011

PhD thesis: “Improving diagnosis and therapy of sensorineural hearing loss: translational studies in animal models and humans” 194 pages. 2017. http://repositorium.meduniwien.ac.at/obvumwhs/download/pdf/2393523?originalFilename=true

Editorial: “Why the House Tax Plan on Tuition Waivers is Bad for Science and for America” with the American Society of Gene and Cell Therapy (ASGCT) Trainee Committee. 2017

Completion of all courses for the diploma in acupuncture of the Austrian Medical Chamber

Course in Medical Education at Medical University of Vienna Various courses at Harvard Medical School (e.g. Responsible Conduct of Research,

Improving Mouse Colony Management Efficiency, Fundamentals of Clinical Translational Research, Certificate of Applied Biostatistics…)

Several courses concerning rhetorical and presentation skills at different institutions Translation of abstracts for the journal Pediatric Allergy and Immunology on a regular

basis (in conjunction with the JMA-PAI collaboration) Mini-MBA at Harvard Business School in summer 2015: The Mini-MBA course is an

intensive summer business course for non-business post-docs and graduate students organized by the Harvard GSAS Business Club. Classes are taught by Harvard Business School professors in the traditional HBS case method.

United States Medical Licensing Examination – Step 1 Scientific memberships: Junior Member of the European Academy of Allergy and Clinical Immunology

(EAACI) since 2011 and Austrian Junior Member Representative/Country Liaison 2013/2014

Member of the work group Allergology of the Austrian Society of Dermatology and Venereology (ÖGDV) since 2012

Member of the Young Scientist Association (YSA) of the Medical University of Vienna 2012-2018

Member of the network of Austrian Scientists & Scholars in North America (ASciNA) since 2013, Boston Chapter Steering Committee since 2014

Member of the Harvard Club of Austria (Student Chapter) since 2013, President 2014/2015, Vice-President 2015/2016

Member of the European Rhinologic Society (ERS) since 2013 Junior Member of the World Allergy Organization (WAO) since 2013 Associate Member of the Association for Research in Otolaryngology (ARO) since

2013, Animal Committee Representative of the student, postdoc and medical resident chapter of the Association for Research in Otolaryngology (spARO) 2013/2014-2014/2015, spARO Steering Committee Member since 2014, spARO Chair-Elect and ex officio of the ARO council 2015/2016, spARO Exiting Chair 2016/2017

Associate Member of the American Society of Gene and Cell Therapy (ASGCT) since 2016, Member of the ASGCT Trainee Committee since 2016, Co-chair 2018/2019

Member of the International Otopathology Society (Schuknecht Society) since 2016

Trainee Member of the American Neurotology Society (ANS) since 2016 Language skills: My mother tongue is German. In addition, I have knowledge of several other foreign

languages:

I started to learn English in 1995 and was taught the language for 10 years at school. I passed the CAE (= Cambridge Certificate of Advanced English) in 2004 with the grade B, the TOEFL iBT (= Test Of English as a Foreign Language internet-Based Test) in 2010 with 114 out of 120 points, and the IELTS (= International English Language Testing System) in 2011 with 8.0 out of 9.0 points. Furthermore, I’ve traveled to various English-speaking countries including four times to the US and several times the UK to spend language holidays there. I’ve also passed the course “English for Clinical Purposes” / ”Hospital English for Clinicians”, which is the highest certificate concerning Medical English skills available at the Medical University Innsbruck and where I acquired “a very good command of the language skills required for working in a clinical setting”. My medical trainings in Singapore, Sydney, New York, Oxford, New Orleans, and Boston have helped me to enhance my English as well.

I also studied French for six years at school and participated in a language exchange

for two weeks during that time. I went to Paris in 2006 to practice French again and in 2008 I studied French at the University of Innsbruck for one semester (level C1 in the Common European Framework of Reference for Languages). Of course, my stay in Paris with the ERASMUS program ameliorated my language skills tremendously.

I learned Latin for four years at school, which helps me now in studying medicine. Furthermore, I studied Spanish at the University of Innsbruck beginning in 2007 for

three semesters (level B2 in the Common European Framework of Reference for Languages), and I’ve been to Spain several times to practice the language. I made huge progress concerning my knowledge of this language during my working experience in Madrid and also while staying Barcelona for a month in June / July 2011.

Hobbies: Football, snowboarding, golf, sailing, scuba diving, reading, music, running

(successful participation in the 2018 Boston Marathon after raising $8000 for hearing research)