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TRANSCRIPT
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Tabla 1: Características clínicas, demográficas y factores de riesgo, de los individuos con AAA y NA incluidos en el estudio.
Medidas Niveles mRNA Niveles TNFαα plasma
Características AAA NA AAA Controles Número 89 25 79 39 Diámetro aórtico (mm)a 66±12.7 - 64.3±11.6 - SD (<55 mm) 13 (14.6%) - 14 (17.7%) - MD (55-69.9 mm) 43 (48.3%) - 40 (50.6%) - LD (≥70 mm) 33 (37.1%) - 25 (31.6%) - Edad (años) 71.1±6.5 56.3±16.0 72.4±6.8 62.9±3.0 Hombres 87 (97.8%) 16 (64%) 75 (94.9%) 34 (87.2%) Diabetes mellitus 19 (21.3%) 2 (8%)b 21 (26.6%) 1 (2.6%) Hipertensión 63 (70.8%) 2 (8%)b 60 (75.9%) 14 (35.9%) Dislipemia 54 (60.7%) 2 (8%)b 51 (64.6%) 1 (2.6%) Hábito tabáquico No fumadores 7 (7.9%) 21 (84%)b 8 (10.1%) 30 (76.9%) Fumadores activos 26 (29.2%) 3 (12%)b 19 (24.1%) 6 (15.4%) Ex fumadoresc 56 (62.9%) 1 (4%)b 52 (65.8%) 3 (7.7%) Cardiopatía isquémica 20 (22.4%) 0b 22 (27.9%) 0 Angina de pecho 2 (2.2%) 0b 4 (5.1%) 0 Infarto de miocardio 6 (6.7%) 0b 6 (7.6%) 0 Cirugía revascularización coronariad 12 (13.5%) 0b 12 (15.2%) 0 Insuficiencia renal crónicae 34 (38.2%) 0b 23 (29.1%) 0 Diálisis 0 0b 0 0 Enfermedad arterial periférica 48 (53.9%) 0b 45 (57%) 0 Ausencia de pulsos 31 (34.8%) 0b 30 (38%) 0 Claudicación intermitente 17 (19.1%) 0b 15 (19%) 0 Enfermedad cerebrovascular 7 (7.9%) 1 (4%)b 7 (8.8%) 0 Accidente vascular cerebral 4 (4.5%) 1 (4%)b 5 (6.3%) 0 Ataque isquémico transitorio 3 (3.4%) 0b 2 (2.5%) 0 EPOCf 26 (29.2%) 0b 17 (21.5%) 0 Tratamiento con antiagregantes 47 (53.4%) 1 (4%)b 48 (61.5%) 0 Tratamiento con estatinas 57 (64%) 0b 58 (73.4%) 7 (17.9%) Tratamiento con IECAs(g) 23 (20.7%) 0b 24 (30.8%) 6 (15.4%) Tratamiento con AINEs(h) 6 (6.7%) 0b 3 (3.8%) 0 Tratamiento con corticoides 6 (6.7%) 0b 4 (5.1%) 0 Tratamiento con inmunosupresores 4 (3.5%) 0b 2 (2.5%) 0 Las variables nominales se presentan como números y porcentajes (%) y las variables continuas como mediana ±DE. (a) Diámetro transversal máximo medido en mm: SD “Small Diameter”, MD “Moderate Diameter” y LD “Large Diameter”. (b) En algunos casos y debido a la naturaleza de las muestras de aorta sana, algunas de las características clínicas pueden no estar
recogidas y existe riesgo de infravaloración de las mismas.. (c) Ex fumadores: abandono del Tabaco de >1 año. (d) Mediante cirugía convencional o tratamiento endovascular. (e) Filtrado glomerular estimado (eGFR) <60 mL/min/1.73 m2. (f) Enfermedad Pulmonar Obstructiva Crónica. (g) IECAs: Inhibidores Enzima Conversora Angiotensina. (h) AINEs: Anti Inflamatorios No Esteroideos.
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TABLA 2: Transcritos determinados (mRNA)
MARCADORES CELULARES Y CITOCINAS
VÍA PGE2
METALOPROTEINASAS
VE-Cadherin TIE-1 vWF eNOS VEGFR-2 CD45 CD68 FLAP BTL-1 NAP-2 VEGF-A VEGFR-1 VEGFR-2 α-Actina
COX-1 COX-2 mPGES-1 EP-1 EP-2 EP-3 EP-4
MMP-2 MMP-9
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Tabla 3: anticuerpos y diluciones utilizados
Antígeno reconocido Tipo Dilución Proveedor Técnica de análisis
COX-2 Policlonal de conejo 1/50 Cayman ABC-POD
EP2 Policlonal de conejo 1/1000 Cayman ABC-POD
EP3 Policlonal de conejo 1/400 Cayman ABC-POD
EP4 Policlonal de conejo 1/100 Cayman ABC-POD
mPGES-1 Policlonal de conejo 1/50 Sigma ABC-POD
vWF Monoclonal de ratón 1/35 Dako ABC-POD
CD45 Monoclonal de ratón - Dako ABC-POD Fluorescencia
CD68 Monoclonal de ratón - Dako ABC-POD Fluorescencia
MMP-2 Monoclonal de ratón 1/15 Abcam ABC-POD Fluorescencia
MMP-9 Policlonal de conejo 1/15 Abcam ABC-POD Fluorescencia
α-actina Policlonal de conejo 1/200 Abcam Fluorescencia
ABC-POD: Avidina biotin
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Aorta diameterNA SD MD LD
mR
NA
norm
aliz
ed m
edia
n
0.0
0.2
0.4
0.6
0.8
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VE-Cadherin VEGR-2 vWF TIE-1 eNOS media
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mR
NA
Log 10
, rel
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3
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CD
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NAP
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CD
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Aorta diameterNA SD MD LD
mR
NA
norm
aliz
ed m
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n
0.0
0.2
0.4
0.6
0.8
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FLAP BTL-1 CD45 CD68 NAP-2 media
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Aorta diameterNA SD MD LD
mR
NA
norm
aliz
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0.6
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FLAP BTL-1 CD45 CD68 NAP-2 media
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mR
NA
Log 1
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2
3
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VEGF-A VEGFR-1 VEGFR-2
NAAAA
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Tabla 2.1: Niveles de transcrito de VEGF-A y de sus receptores en muestras de AAA estratificadas según los factores de riesgo cardiovasculares y enfermedades de base. El número de pacientes de cada grupo se ha indicado previamente en la tabla 1 y los datos se expresan relativos a β-actina x1000.
Mediana Percentil 25º-75º Valor p vs ausenciaa
VEGF-A
No fumadores 31.8 21.9-48.7 Fumadores 38.3 20.6-74.8 0.446
No insuficiencia renal 32.4 22.1-50.2 Insuficiencia renal 31.8 19.7-65.6 0.910
No hipertensión 30.1 22.6-60.4 Hipertensión 32.9 19.7-58.6 0.925
No diabetes mellitus 34.4 22.1-52.6 Diabetes mellitus 28.0 17.0-117.7 0.806
No Dislipemia 32.9 19.7-58.6 Dislipemia 31.8 22.7-60.7 0.740
No EPOCb 28.4 20.9-54.6 EPOC 41.9 21.6-71.6 0.202 VEGFR-1
No fumadores 4.55 2.75-7.11 Fumadores 5.04 3.27-7.61 0.361
No insuficiencia renal 4.89 3.08-9.49 Insuficiencia renal 4.05 2.67-6.56 0.239
No hipertensión 4.99 2.91-6.90 Hipertensión 4.56 2.72-8.62 0.810
No diabetes mellitus 4.79 3.73-7.11 Diabetes mellitus 3.00 1.75-8.19 0.037
No Dislipemia 4.77 2.82-7.33 Dislipemia 4.62 2.88-6.90 0.788
No EPOCb 4.65 2.88-6.47 EPOC 4.56 2.79-8.62 0.988 VEGFR-2
No fumadores 10.4 6.29-18.6 Fumadores 13.9 9.78-20.3 0.032c
No insuficiencia renal 10.9 7.23-16.7 Insuficiencia renal 13.6 7.89-27.1 0.208
No hipertensión 9.91 7.89-12.9 Hipertensión 12.2 7.88-22.9 0.183
No diabetes mellitus 12.2 8.37-19.1 Diabetes mellitus 8.75 5.09-14.3 0.095d
No Dislipemia 13.4 9.01-24.2 Dislipemia 10.9 7.88-14.9 0.253
No EPOCb 11.0 8.01-18.0 EPOC 14.4 7.64-28.2 0.657
(a) Mann-Whitney Rank Sum Test. (b) EPOC: Enfermedad Pulmonar Obstructiva Crónica. (c) Se encontró p=0.06 aplicando Mann-Whitney Rank Sum Test; tras transformación logarítmica se obtuvo una distribución normal y se encontró p=0.032 aplicando t-Student. (d) Tras transformación logarítmica se obtuvo una distribución normal y se encontró p=0.233 aplicando t-Student.
![Page 122: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/122.jpg)
χ
![Page 123: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/123.jpg)
Tabla 2.2: χ2Análisis de los factores de riesgo y enfermedades asociadas . Variables EPOC Fumadores
activos Diabetes Mellitus
Dislipemia Insuficiencia Renal
HTA χ2=1.494 p=.222
χ2=3.371 p=.066
χ2=1.801 p=.180
χ2=.0318 p=.859
χ2=4.448 p=.035
EPOC χ2=8.464 p=.004
χ2=.0006 p=.981
χ2=.082 p=.775
χ2=9.952 p=.002
Fumadores activos χ2=.0326 p=.857
χ2=.0009 p=.976
χ2=1.223 p=.269
Diabetes mellitus χ2=2.55 p=.110
χ2=.04 p=.842
Dislipemia χ2=.003 p=.957
HTA: Hipertensión arterial EPOC: Enfermedad Pulmonar Obstructiva Crónica
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VEGFR-2
mRNA vWFLog10, relative to -actin
1 2 3-1
0
1
2
3
VEGFR-1
1 2 3mR
NA
Log 10
, rel
ativ
e to
-a
ctin
-1
0
1
2 VEGFR-1
-1 0 1 2-1
0
1
2
VEGFR-2
mRNA a-ActinLog10, relative to -actin
-1 0 1 2-1
0
1
2
3
R=0.300; p=0.015
R=0.614; p=4.19·10-8
R=0.364; p=0.003
R=0.643; p=2.0·10-7
α
![Page 125: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/125.jpg)
VEGFR-2
mRNA CD45Log10, relative to -actin
0 1 2 3-1
0
1
2
3
VEGFR-1
0 1 2 3mR
NA
Log 10
, rel
ativ
e to
-a
ctin
-1
0
1
2 VEGFR-1
1 2 3 4-1
0
1
2
VEGFR-2
mRNA CD68Log10, relative to -actin
1 2 3 4-1
0
1
2
3
R=0.328; p=0.007
R=0.410; p=6.8·10-4 R=0.395; p=0.001
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mR
NA
Log 1
0 re
lativ
e to
-a
ctin
-2
-1
0
1
2
3
4
MMP-2 MMP-9
*** ***
NAAAA
![Page 129: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/129.jpg)
Aorta diameterNA SD MD LD
mR
NA
MM
P-9
rela
tive
to
-act
in
0
20
40
60
80
100
120
140
160
**
P=0.07 P=0.021
Aorta diameterNA SD MD LD
mR
NA
MM
P-2
rela
tive
to
-act
in
0
100
200
300
400
* * *
median25th percentile 75th percentile
![Page 130: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/130.jpg)
x600
NA
![Page 131: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/131.jpg)
Figura 3.5: Detalle inmunotinción para MMP-2 en VSMC capa media de muestras de AAA.
AAA b
x400
b
x100
b
AAA
AAA
x600
AAA
x400
![Page 132: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/132.jpg)
mRNA MMP-2Log10, relative to -actin
1 2 3 4
mR
NA
CD
68Lo
g 10,
rela
tive
to
-act
in
1
2
3
4
R=0.276; p=0.025
1 2 3 4
mR
NA
-act
inLo
g 10,
rela
tive
to
-act
in
-1
0
1
2
mRNA MMP-2Log10, relative to -actin
1 2 3 4
mR
NA
CD
45Lo
g 10,
rela
tive
to
-act
in
0
1
2
3
R=0.252; p=0.017
R=0.509; p=4.61·10-7
1 2 3 4
mR
NA
vWF
Log 1
0, re
lativ
e to
-a
ctin
0
1
2
3
R=0.407; p=9.27·10-5
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Figura 3.10: Detalle inmunotinción para MMP-9 capa media, en muestras de AAA.
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mRNA MMP-9Log10, relative to -actin
0 1 2 3 4
mR
NA
CD
68re
lativ
e to
b-a
ctin
1
2
3
4
R=0.604; p=7.25·10-8
0 1 2 3 4
mR
NA
vWF
Log 1
0, re
lativ
e to
-a
ctin
0
1
2
3
-1 0 1 2
mR
NA
-act
inre
lativ
e to
b-a
ctin
0
1
2
3
4
mRNA MMP-9Log10, relative to -actin
0 1 2 3 4
mR
NA
CD
45re
lativ
e to
b-a
ctin
0
1
2
3
R=0.279; p=0.008
![Page 137: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/137.jpg)
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Tabla 3.1: Niveles de transcritos de MMP-2 y de MMP-9 en muestras de aorta aneurismática (AAA) estratificadas en función de los factores de riesgo cardiovasculares. El número de pacientes de cada grupo se ha mostrado previamente en la Tabla 1. Los datos se expresan relativos a β-actina x1000.
Median 25th-75thpercentile p value vs no-factora
MMP-2
No fumadores 184.4 100.0-320.5 Fumadores 349.5 219.5-408.4 <0.001
No insuficiencia renal 177.3 99.3-326.9 Insuficiencia renal 286.8 189.6-410.8 0.004
No hipertensión 232.7 170.2-335.8 Hipertensión 216.2 109.5-394.8 0.818
No diabetes mellitus 217.0 132.6-351.4 Diabetes mellitus 224.3 86.5-394.1 0.908
No Dislipemia 219.5 104.7-347.3 Dislipemia 221.0 132.6-363.4 0.734
No EPOCb 207.0 109.5-334.9 EPOC 232.4 170.0-404.3 0.107
MMP-9
No fumadores 67.2 38.8-122.5 Fumadores 61.7 35.4-110.1 0.573
No insuficiencia renal 64.9 38.1-119.1 Insuficiencia renal 75.8 29.1-120.2 0.997 No hipertensión 65.6 37.8-110.1 Hipertensión 66.0 34.3-123.0 0.662 No diabetes mellitus 67.7 38.1-119.1 Diabetes mellitus 60.9 31.3-120.2 0.678 No Dislipemia 72.8 41.6-143.3 Dislipemia 62.2 26.6-115.0 0.231 No EPOCb 64.1 39.0-135.6 EPOC 67.1 26.6-105.3 0.617
(a) Mann-Whitney Rank Sum Test. (b) EPOC: Enfermedad Pulmonar Obstructiva Crónica.
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mR
NA
Log 1
0 re
lativ
e to
-a
ctin
-1
0
1
2
3
COX-2 mPGES-1
*** *
NAAAA
***
COX-1
![Page 145: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/145.jpg)
β
Aorta diameterNA SD MD LD
mR
NA
CO
X-1
rela
tive
to
-act
in
0
2
4
6
8
10
12
14
16
18
* * *
median25th percentile 75th percentile
Aorta diameterNA SD MD LD
mR
NA
CO
X-2
rela
tive
to
-act
in
0
2
4
6
8
10
12
14
16
18
20
**
*
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a b
![Page 147: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/147.jpg)
b
![Page 148: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/148.jpg)
COX-2
mRNA vWFLog10, relative to β-actin
1 2 3-1
0
1
2
3
COX-1
1 2 3
mR
NA
Log 10
, rel
ativ
e to
β-a
ctin
0
1
2 COX-1
-1 0 1 20
1
2
COX-2
mRNA αα-actinLog10, relative to β-actin
-1 0 1 2-1
0
1
2
3
COX-2
mRNA CD45Log10, relative to β-actin
0 1 2 3-1
0
1
2
COX-1
0 1 2 3
mR
NA
Log 10
, rel
ativ
e to
β-a
ctin
0
1
2 COX-1
1 2 3 40
1
2
COX-2
mRNA CD68Log10, relative to β-actin
1 2 3 4-1
0
1
2
3
R=0.670; p=2∑10-7
![Page 149: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/149.jpg)
![Page 150: D)'0!) % ! '*. /*-!. ! -%!.#* - %*1 . 0' - !) '*. )%1 · Ł klh o k 0-12 ,-'" 0#!#.2-0 lp - 0#!#.2-0 "# *-1 .0-12 ,-'"#1 kli Ł h o k 0-12 ,-'" 0#!#.2-0 p - 0#!#.2-0 "# .0-12 ,-'"#1](https://reader030.vdocuments.net/reader030/viewer/2022012823/5d310a2e88c993a7488d8c9b/html5/thumbnails/150.jpg)
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Figura 4.11: Correlación entre la expresión de mPGES-1 y los marcadores de diferentes estirpes leucocitarias.
mRNA CD45Log10, relative to -actin
0 1 2 3
mR
NA
mPG
ES-1
Log 10
, rel
ativ
e to
-a
ctin
-1
0
1
2
mRNA CD68Log10, relative to -actin
1 2 3 4-1
0
1
2
mRNA vWFLog10, relative to -actin
1 2 3
mR
NA
mPG
ES-1
Log 10
, rel
ativ
e to
-a
ctin
-1
0
1
2
mRNA -actinLog10, relative to -actin
-1 0 1 2-1
0
1
2
R=0.522; p=2.78·10-6R=0.718; p=2·10-7
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Aorta diameterNA SD MD LD
mR
NA
mP
GE
S-1
rela
tive
to
-act
in
0
1
2
3
4
5
median25th percentile 75th percentile
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EP-2 EP-3 EP-4EP-1
mR
NA
Log 10
rela
tive
to
-act
in
-4
-3
-2
-1
0
1
2*********
NAAAA
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MVEC VSMC
% o
f mR
NA
rela
tive
to
-act
in
0
20
40
60
80
100 EP-1 EP-2 EP-3 EP-4
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mRNA CD45Log10, relative to -actin
0 1 2 3
mR
NA
EP-4
Lo
g 10, r
elat
ive
to
-act
in -1
0
1
2
mRNA vWFLog10, relative to -actin
1 2 3-1
0
1
2
mRNA CD68Log10, relative to -actin
1 2 3 4-1
0
1
2
mRNA -actinLog10, relative to -actin
-1 0 1 2-1
0
1
2
R=0.449; p=1.33·10-5 R=0.439; p=2·10-5
R=0.552; p=2.42·10-8 R=0.329; p=0.007
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Aorta diameterNA SD MD LD
mR
NA
EP-4
rela
tive
to
-act
in
0
2
4
6
8
10
** *
median25th percentile 75th percentile
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Tabla 4.1. Transcrito de isoenzimas COX y de mPGES-1 en muestras de AAA estratificadas según factores de riesgo y enfermedades concomitantes. El número de pacientes de cada grupo se indica en la tabla 1 (Material y Métodos), los datos se expresan relativos a β-actina x1000.
Mediana Percentil 25º-75º Valor p vs ausenciaa
COX-1
No fumadores 10.7 7.68-14.3 Fumadores 11.6 9.47-18.7 0.109
No insuficiencia renal 10.9 8.50-16.3 Insuficiencia renal 10.7 7.78-15.8 0.896 No hipertensión 10.8 9.62-16.1 Hipertensión 10.7 7.49-15.8 0.419 No diabetes mellitus 11.0 8.67-15.9 Diabetes mellitus 9.71 6.48-15.1 0.365 No Dislipemia 12.3 8.20-16.1 Dislipemia 10.6 8.39-14.3 0.457 No EPOCb 11.0 8.45-15.9 EPOC 10.4 8.07-15.3 0.695
COX-2 No fumadores 10.1 4.68-15.8 Fumadores 10.3 5.34-17.6 0.604 No insuficiencia renal 9.27 5.25-18.7 Insuficiencia renal 10.9 5.30-14.6 0.678
No hipertensión 8.57 5.09-16.7 Hipertensión 10.4 5.70-16.0 0.695
No diabetes mellitus 9.27 4.70-15.9 Diabetes mellitus 11.6 6.90-24.7 0.188
No Dislipemia 9.28 5.36-16.5 Dislipemia 10.6 5.09-15.8 0.990
No EPOCb 10.1 5.20-16.5 EPOC 10.6 5.60-15.0 0.889
mPGES-1
No fumadores 2.42 1.16-4.08 Fumadores 3.46 2.33-4.95 0.009
No insuficiencia renal 2.69 1.24-3.82 Insuficiencia renal 2.69 1.90-4.67 0.245
No hipertensión 2.87 1.74-3.67 Hipertensión 2.66 1.48-4.46 0.735
No diabetes mellitus 2.78 1.50-4.26 Diabetes mellitus 2.47 1.20-4.36 0.606
No Dislipemia 2.66 2.06-3.65 Dislipemia 2.76 1.20-4.51 0.798
No EPOCb 2.39 1.16-4.09 EPOC 2.90 2.35-4.75 0.057c
(a) Mann-Whitney Rank Sum Test. (b) EPOC: Enfermedad Pulmonar Obstructiva Crónica. (c) Se encontró p=0.06 aplicando Mann-Whitney Rank Sum Test; tras transformación logarítmica se obtuvo una
distribución normal y se encontró p=0.057 aplicando t-Student.
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Tabla 4.2. Niveles plasmáticos de PGE2 en muestras de AAA estratificadas según factores de riesgo y enfermedades concomitantes. El número de pacientes de cada grupo se indica en la tabla 1 (Material y Métodos). Niveles de plasma de PGE2 se expresan en pg/mL.
Mediana Percentil 25º-75º Valor p vs ausenciaa
Plasma-PGE2
No fumadores 55.9 39.3-71.1 Fumadores 68.0 57.1-119.5 0.008 No insuficiencia renal 58.4 44.0-71.4 Insuficiencia renal 59.4 39.3-104.3 0.786
No hipertensión 70.1 53.0-95.2 Hipertensión 56.2 39.4-77.2 0.140
No diabetes mellitus 56.5 38.6-94.9 Diabetes mellitus 60.7 55.8-68.8 0.294
No Dislipemia 55.8 44.5-101.9 Dislipemia 60.7 41.2-72.0 0.947
No EPOCb 59.4 43.3-74.3 EPOC 57.1 43.5-115.9 0.807
(a) Mann-Whitney Rank Sum Test (b) EPOC: Enfermedad Pulmonar Obstructiva Crónica.
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Tabla 4.3. Transcrito de niveles de receptores PGE2 en muestras de AAA estratificadas según factores de riesgo y enfermedades concomitantes. El número de pacientes de cada grupo se indica en la tabla 1 (Material y Métodos). los datos se expresan relativos a β-actina x1000.
Mediana Percentil 25º-75º Valor p vs ausenciaa
EP-2
No fumadores 3.98 2.53-8.63 Fumadores 4.84 2.42-7.46 0.811 No insuficiencia renal 3.98 2.66-9.05 Insuficiencia renal 4.49 2.41-7.72 0.653 No hipertensión 4.58 2.42-8.22 Hipertensión 4.10 2.56-8.41 0.946
No diabetes mellitus 3.98 2.45-7.24 Diabetes mellitus 5.27 2.88-23.6 0.115
No Dislipemia 3.91 2.38-6.60 Dislipemia 5.31 2.82-12.0 0.068
No EPOCb 3.98 2.51-9.82 EPOC 4.95 2.60-7.46 0.846
EP-3
No fumadores 2.80 1.30-6.18 Fumadores 3.41 2.16-6.32 0.202
No insuficiencia renal 2.68 1.47-4.74 Insuficiencia renal 3.36 1.94-8.02 0.172
No hipertensión 3.12 1.98-5.74 Hipertensión 3.06 1.45-6.30 0.484
No diabetes mellitus 3.18 1.87-5.67 Diabetes mellitus 1.94 0.64-10.4 0.305
No Dislipemia 3.47 1.82-7.19 Dislipemia 2.54 1.46-5.32 0.288
No EPOCb 3.16 1.49-6.05 EPOC 2.95 1.92-6.21 0.853
EP-4 No fumadores 4.29 3.24-6.49 Fumadores 5.93 4.87-8.92 0.007 No insuficiencia renal 4.63 3.47-6.25 Insuficiencia renal 5.70 3.45-7.72 0.259
No hipertensión 4.89 3.94-7.72
Hipertensión 4.93 3.45-6.61 0.394
No diabetes mellitus 4.92 3.48-6.66 Diabetes mellitus 4.71 1.82-7.96 0.678
No Dislipemia 4.90 3.26-6.61 Dislipemia 4.91 3.51-7.32 0.678
No EPOCb 4.90 3.52-6.57 EPOC 5.20 2.41-7.61 0.896
(a) Mann-Whitney Rank Sum Test (b) EPOC: Enfermedad Pulmonar Obstructiva Crónica
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