danjoungbio’s patented raw material from natural materials ......01_summary specialized natural...

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S k i n C o o l i n g & A n t i - h e a t a g i n g

Danjoungbio ’s Pat en t ed R a w m a t er i a l

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01_Summary

Specialized natural material research and development company.

DANJOUNGBIO

Endless research and development of new natural materials. Danjoungbio Co., Ltd. will guide you.

Trustful company that commits to creative development with a sincere heart, a faithful

attitude, and a consistent attitude.

DanjoungbioCo., Ltd. aims to be a global natural material company.


01_Summary

Soothing Cooler®Soothing of skin by removing the over-heat on skin and scalp.

INCI Name

Aloe Barbadensis Leaf Extract, Laminaria Japonica Extract, Dioscorea

Japonica Root Extract, Ulmus Davidiana Root Extract, Viola Mandshurica

Flower Extract

Recommended dose

Emulsified product : 2%

Effects and Area of Use

Skin soothing effect

Anti-heat aging products

Skin Cooling effect

Skin Moisturizing effect

Hair loss prevention effect

Solubilized product : 5%

- Soothing Cooler®

Skin protection from dry environment


02_Background

Hair loss caused by heat generation in the head area

- Effects of Heat on Skin / Hair

Poor elasticity and wrinkles caused by skin aging

Hair dryerCar heater HeaterElectric heater

Strong solar heat

Attention to skin aging and hair loss caused by excessive heat

[Excessive heat will damage cells in the human body]

Skin and scalp alteration caused by damaged cells

SKIN HAIR


02_Background

- Effects of Heat on Skin / Hair

Heat aging Alopecia areata

Refer to related paper

heat treatment significantly increased the incidence of Alopecia areata

Thermal aging :increase expressions of MMP-1,MMP-3, MMP-12decrease of collagen and elastic fibers

[Reference]1) Seo, J. Y., & Chung, J. H. (2006). Thermal aging: a new concept of skin aging. Journal of Dermatological Science Supplement, 2(1), S13-S22.2) Schieke, S. M., Schroeder, P., & Krutmann, J. (2003). Cutaneous effects of infrared radiation: from clinical observations to molecular response mechanisms. Photodermatology, photoimmunology & photomedicine, 19(5), 228-234.

[Reference]1) 정진란. (2011). 두정부열이 탈모에 미치는 영향에 대한 연구. 대한피부미용학회지, 9(2), 115-123.2) Wikramanayake, T. C., Alvarez-Connelly, E., Simon, J., Mauro, L. M., Guzman, J., Elgart, G., ... & Jimenez, J. J. (2010). Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model. Cell Stress and Chaperones, 15(6), 985-991.


03_Ingredients

- Composition of Soothing Cooler

Natural Derived Extract

Aloe Barbadensis Laminaria Japonica Dioscorea Japonica Ulmus Davidiana Viola Mandshurica

Wound healingStimulation reliefAnti-microbial,

anti-inflammation and anti-oxidation

Prevention of agingBoosting Immunity

Anti-microbial, anti-oxidation

Anti-inflammation Purulent skin disease treatment

Anti-inflammation

* 원료적 특성에 한함

Five materials that make up Soothing Cooler


04_Mechanism

Skin barrier protection,

Soothing and Cooling effect

by discharged out of the skin in heat

- Soothing Cooler’s Mechanism

Anti-Heat Aging : Mechanism


04_Mechanism

- Soothing Cooler’s Mechanism

* The sol-gel and can be a transition by external

conditions(temperature, pressure, pH)

Soothing Cooler heat absorption Process

1. Soothing Cooler-Phyto-muco saccharide gel

2. Applied on the skin (Heat absorption)

3. Soothing Cooler viscosity is lowered(gel->sol)

Soothing Cooler® (피부열흡수)Releases the heat of the skin

Soothing CoolerGel

Soothing CoolerSol

Absorbs the heat of the skin

Mechanism of heat release in the skin through

Sol-Gel reaction of Soothing Cooler

Sol-Gel


05_Mechanism

- Soothing Cooler’s Application

SKIN TYPE HAIR TYPE

&

Prevention of hair loss due to reduced heat of the head

Prevention of heat aging due to reduced skin heat

Hair MistGel

SunBlock


05_Effect

-0.5

2.5

5.5

8.5

11.5

14.5

0 1 3 5 10 15 20 25 30

WaterSoothing Cooler(100%)Aloe extractL. Japonica extractD.Japonica extractU.Davidiana extractV.Mandshurica extract

Time (min)

Ski

n h

eat

inh

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rat

e(%

)

- Effect of Soothing Cooler

Comparison for heat removal effect

of 5 ingredients extract and Soothing Cooler

Anti-heat aging effect

Excessive heat removal effect in Skin

- It was confirmed that the 5 types of extract had higher heat

removal efficiency than purified water.

- Among the five extracts, aloe extract shows the highest

efficiency for heat removal

- Soothing Cooler showed the highest heat removal rate, which was

confirmed to have a higher heat removal rate than the aloe extract.


05_Effect

[Test sample]

El1 : Soothing Cooler® El2 : Ethanol El3 : Water

Control(Untreat)

Treat sample After 7 min After 20 minAfter 3 min After 10 min

Sample TreatTime(min)

-2.0

0.0

2.0

4.0

6.0

8.0

10.0

-1 0 1 2 3 4 5 6 7 8 9 101112131415161718192021222324252627282930

Ski

n h

eat

inh

ibit

ion

rat

e(%

)

Water

Ethanol

Soothing Cooler®

0- +


Anti-heat aging effectSoothing Cooler 100%


- After applying, photographing the patched area with a thermal imaging camera to measure the temperature difference. (Before applying, 0 min after applying and after applying was checked to see temperature difference.)

- Heat removal rate of ethanol and purified water decreased rapidly within 3 minutes of application.

- Soothing Cooler continuously showed a high heat removal rate for about 10 minutes, and its efficacy gradually decreased, confirming that it is effective for removing heat in the skin.


05_Effect


0.0

2.0

4.0

6.0

8.0

10.0

12.0

14.0

16.0

0 10 20 30 40 50 60

Ski

n h

eat

inh

ibit

ion

rat

e(%

)

Soothing Cooler

Soothing cooler(크림)

Soothing cooler(액상)

에탄올


- +0

Soothing Cooler®

Emulsion type product (Soothing Cooler® 2%)

Soluble type product (Soothing Cooler® 5%)

Ethanol

Control(Untreat)

After 60 minAfter 5 min After 30 min

100%

Ethanol 95%

Soothing Cooler 100%

Anti-heat aging effect



- Ethanol has significantly increased the heat loss rate immediately after applying, but has decreased rapidly since.

- Soothing Cooler and contained products showed similar heat reduction efficiency. Among these, it was confirmed that the heat reduction ratio of emulsion type products was most stable.

[Test sample]

El1 : Emulsion type product(Soothing Cooler® 2% contained)

El2 : Soluble type product(Soothing Cooler® 5% contained)

El3 : Soothing Cooler® El4 : Ethanol 95%


05_Effect


[Test sample]

El1 : Soothing Cooler® El2 : Water

Control(Untreat)

After 20 minAfter 5 min After 40 min

0.0

4.0

8.0

12.0

16.0

20.0

0 5 10 20 30 40

Hea

d S

kin

hea

t in

hib

itio

n r

ate(

%)

Soothing cooler

Water


Soothing Cooler 100%

WaterAnti-heat aging effect

Excessive heat removal effect in Scalp


- Heat removal rate of purified water rapidly decreased after 10 minutes of application.

- Soothing Cooler confirmed that the heat removal rate was higher than purified water, and the high heat removal rate was maintained, so it was more efficient for heat removal of the scalp than purified water.


06_Effect


The Plant Resources Society of Korea

The 9th International Symposium on Fermented Korean Medicines (ISKF2015) & International Conference of The Plant Resources Society of Korea

Patented Product

Patent no. 10-1793098Natural plant complex extract that regulates skin heat and cosmetic composition for inhibiting skin heat aging containing the same

Best Poster Prize


S o o t h i n g C o o l e r ®

Soothing skin & Scalp and inhibition of Skin heat agingAnd Hair Loss Prevention effect by removing the over-heat on skin

07_Conclusion

Skin Soothing effect

Anti-heat Aging effect

Hair Loss Prevention effect

*Soothing Cooler : patented product

Skin Moisturizing effect

Skin Cooling effect

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DANJOUNGBIO R&D Center

85, Homaegok 1-gil, Hojeo-myeon, Wonju-si, Gangwon-do,

Republic of Korea

T. +82-33-763-7185 R&D. +82-33-743-7184

F. +82-33-763-7186

E-mail. [email protected]

www.danjoungbio.com

THANK YOU


danjoungbio’s patented raw material from natural materials ......01_summary specialized natural...

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