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Infectivity and toxicity are distinct

Selective targeting/uptake(receptors) Selective propagation(chaperones) Selective toxicity(downstream pathways)CNSinoculationFamilial prion diseases

PeripheralinoculationPatterns of selective neuropathology in prion diseases

Neuroanatomical spread(trans-synaptic)

NICOLA T. HANNA United States Attorney DAVID M. HARRIS

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