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  • Industrial BiosciencesJim Collins - President

  • Industrial Biosciences

    Mission

    Focused growth through bioprocessing technologies Build on Genencors expertise in designing and operating cell factories

    Leverage Pioneers relationship with growers

    Apply DuPonts capabilities in engineering and advanced materials

    Intersection for innovation across DuPonts competencies

    Agriculture

    and Nutrition

    Industrial

    BiosciencesAdvanced

    Materials

    2

  • Bioactives

    Biomaterials

    Key Segments in Our Business

    Agriculture

    and

    Nutrition

    Industrial

    BiosciencesAdvanced

    Materials

    Bioactives Biomaterials

    Bio-based products End use markets

    Enzymes, proteins,

    peptides

    Food, feed, cleaning,

    paper, personal care

    Biorefineries: Biofuels

    3

    Biorefineries

    Biochemicals

    BiomaterialsCarpet, textiles

    Ethanol

    BiobutanolFuels

  • Bio-based Products End use markets

    Bioactives

    Biomaterials

    Focused on Three Bio-based SegmentsServing a diverse set of customers

    Enzymes, proteins,

    peptides

    Food, feed, cleaning,

    paper, personal care

    Sugars

    Our Competitive Advantage

    Carbon Sources Conversion

    Starch

    Biorefineries: Biofuels

    4

    Biochemicals

    BiomaterialsCarpet, textiles

    Ethanol

    BiobutanolFuels

    Bio/chemical transformation

    Biomass

    SugarsBio/chemical

    transformation

  • Core Elements Renewable, bio-based inputs

    Based on Common Core Elements

    Agriculture

    and

    Nutrition

    Industrial

    BiosciencesAdvanced

    Materials

    Bioactives Biomaterials Renewable, bio-based inputs

    Design and operation of cell factories

    Deliver enhanced process and product

    sustainability

    5

    Biorefineries

    Core

  • Industrial Biosciences

    Developing customer-driven solutions that enhance value creation, reduce

    environmental footprints, and improve health & wellness for end users

    $50B addressable market consisting of: Animal nutrition, food, cleaning/

    detergents, textiles, carpet, personal care, feedstock processing, biofuels

    Our Business

    Our Markets

    Our Business

    Segments

    Bioactives = enzymes, peptides and performance proteins for

    markets such as food, animal nutrition, detergents, textiles

    Biomaterials = advanced materials and intermediates

    manufactured with renewable feedstocks

    Biorefineries = products and technology for converting

    agricultural feedstocks into carbohydrates and fuels

    6

    Long-term growth targets: sales +10-12% CAGR with 15-17% margins

  • Who We Are And Where We Work

    Industrial Biosciences

    is comprised of more

    than 2500 dedicated

    colleagues worldwide

    We discover and

    develop market-based

    biotechnology

    solutions at 8 global

    R&D sites

    DuPont Industrial Biosciences

    R&D sites

    We produce a broad

    portfolio of products

    and manage 19

    operations sites

    Research & Development

    Centers

    Production, Operations and

    Pilot Sites

    7

  • 2011E Sales: $0.7B*

    Industrial Biosciences SalesServing Customers in Multiple Markets Around the World

    Region Business Unit End Market

    ApparelFood

    Enzymes

    Other

    Latin

    America

    8

    BioactivesBiomaterials

    Biorefineries Animal

    nutrition

    Feedstock

    processing

    Detergent

    enzymes

    Carpet

    US & Canada

    EMEA

    Asia

    Pacific

    * Segment sales include transfers.

  • Addressable Market:

    $50 Billion 2011-2015E CAGR

    Animal

    Nutrition$1.5 B

    Growing demand for protein in human diets

    More efficient and sustainable animal

    production

    8 10%

    Detergent

    Enzymes$1 B

    Rising affluence and demand for convenience

    Water and energy conservation5 7%

    Food$1 B

    Natural and clean label7 9%

    Industrial Biosciences MarketsKey Market Trends & Opportunities

    MarketMarket Growth Drivers

    Food

    Enzymes$1 B

    Natural and clean label

    Improved processing and product shelf life7 9%

    Renewable

    Materials$20 B

    Desire for performance and renewability claims

    Supply diversification and stability in feedstocks2 7%

    Biofuels $25+ B Energy supply diversification and environmental

    concerns

    Rural and green economy development7 12%

    9

  • Feedstock / Aggregator Enzyme SupplierConversion EngineeringCatalysts / BiocatalystsApplication

    Development

    DuPont

    DSM

    Novozymes

    Amyris

    Gevo

    Solazyme

    Industry Capabilities Landscape

    Solazyme

    Abengoa

    Poet BP

    1

    Shell

    2

    10

    DuPont strongly positioned across key steps in

    value chain

    DuPont provides unique integrated offerings

    Other participants range in breadth of offering

    Narrow / specialist players must partner to

    access market

    1. Enzymes limited to cellulosic ethanol

    2. Participation primarily through partnerships

  • Industrial Biosciences

    Key R&D Programs

    Customer Benefits / Opportunities R&D Phase

    Su

    sta

    ina

    bili

    ty

    Pro

    du

    ctiv

    ity

    He

    alt

    h &

    we

    llne

    ss

    Fee

    dst

    ock

    div

    ers

    ific

    ati

    on

    Sa

    fety

    an

    d

    Re

    gu

    lato

    ry

    Pe

    tro

    leu

    m/

    che

    mic

    al

    rep

    lace

    me

    nt

    1 2 3 4 5

    Lau

    nch

    Bioactives

    Feed enzyme system: Axtra XAP

    Omega-3

    Cold water washing

    Next generation feed enzyme

    Biosurfaces

    11

    Biomaterials

    Flame retardant fiber for carpet

    Bio-THF

    BioIsoprene

    Biorefineries

    Grain processing: Spezyme RSL

    Cellulosic ethanol

    Biobutanol

    R&D Phases: 1-Discovery; 2-Concept validation; 3-Prototype;

    4-Scale up; 5-Launch preparation

  • Bioactives

    New Feed Enzyme SystemSpecifically designed to help US broiler producers meet the challenge of rising feed costs

    Lower feed costs

    Improved calorie conversion

    More uniform birds

    DuPont science delivers radical feed cost savings

    More uniform birds

    Proven value in antibiotic growth

    promoter free nutrition

    Demonstrated net feed costs

    savings of at least $7 per ton (5%)

    12

  • Biomaterials

    BioIsoprene monomer

    Provide significant raw material cost

    savings vs. synthetic and natural

    rubbers

    Enable cost-competitive replacement

    of natural rubber of natural rubber

    Build platform to access multi-billion

    dollar C5 chemical opportunity

    Partner to produce isoprene monomer

    for Goodyears polyisoprene process

    Pilot plant construction target: 2012

    13

  • Global Biofuels Market

    Large and Growing Addressable Market

    Production surpassed 28 B gallons in 2010

    (3% of total road transport fuel)

    More than 50 countries have enacted biofuel

    targets/mandates -- expected to reach >45 B gallons by

    2020, or >$100B market

    Key drivers: energy independence; tech advancement

    (green jobs); rural development; reduction of greenhouse

    gases

    Biofuel Demand by Type 2010-2050(Source: IEA 2010-11)

    150

    200

    250

    Ethanol conventional (corn)

    Ethanol cane

    Ethanol cellulosic

    Biodiesel conventional

    Biodiesel advanced

    gases

    Industry Challenges for Meeting Demand

    Economies of scale and existing infrastructure still favor

    fossil fuels

    Acceptance of technology risk and capital intensity required

    for capacity build-out

    Policy stabilization and consistency are critical. Change or

    uncertainty discourages investment

    B g

    als

    2010 2050204020302020

    50

    100

    150

    Biojet

    Biomethane

    14

  • Cellulosic EthanolCommercialize lower-cost, lower-capital production technology for biofuels from non-food feedstocks

    Operating demonstration scale

    facility in Vonore, TN. Generating

    data for scale up

    2011 field stover harvest confirmed

    economics for biomass deliveryeconomics for biomass delivery

    Engineering and front-end loading

    underway for Iowa site

    Deployment strategy includes

    commercial operations, licensing

    model and merchant enzymes

    Market/Customers

    Biofuel producers

    Refinery operators

    15

  • Major Biorefinery Program Updates

    Grain Processing BiobutanolCellulosic Ethanol

    Today

    Commercial business serving grain ethanol, sweeteners, and biochemicals industries

    Demo facility in TN proving out commercial economics

    2011 field stover harvest confirmed economics for biomass delivery

    Commercial stover biorefinery site purchased in Iowa

    JV demo facility in UK complete

    Process units being commissioned for integrated operation

    Negotiations in progress for first commercial partnerships

    16

    purchased in Iowa commercial partnerships

    2012

    2014

    Continuous productivity increases f