ddnew industrial biosciences

Industrial BiosciencesJim Collins - President

Industrial Biosciences

Mission

Focused growth through bioprocessing technologies Build on Genencors expertise in designing and operating cell factories

Leverage Pioneers relationship with growers

Apply DuPonts capabilities in engineering and advanced materials

Intersection for innovation across DuPonts competencies

Agriculture

and Nutrition

Industrial

BiosciencesAdvanced

Materials

2

Bioactives

Biomaterials

Key Segments in Our Business

Agriculture

and

Nutrition

Industrial

BiosciencesAdvanced

Materials

Bioactives Biomaterials

Bio-based products End use markets

Enzymes, proteins,

peptides

Food, feed, cleaning,

paper, personal care

Biorefineries: Biofuels

3

Biorefineries

Biochemicals

BiomaterialsCarpet, textiles

Ethanol

BiobutanolFuels

Bio-based Products End use markets

Bioactives

Biomaterials

Focused on Three Bio-based SegmentsServing a diverse set of customers

Enzymes, proteins,

peptides

Food, feed, cleaning,

paper, personal care

Sugars

Our Competitive Advantage

Carbon Sources Conversion

Starch

Biorefineries: Biofuels

4

Biochemicals

BiomaterialsCarpet, textiles

Ethanol

BiobutanolFuels

Bio/chemical transformation

Biomass

SugarsBio/chemical

transformation

Core Elements Renewable, bio-based inputs

Based on Common Core Elements

Agriculture

and

Nutrition

Industrial

BiosciencesAdvanced

Materials

Bioactives Biomaterials Renewable, bio-based inputs

Design and operation of cell factories

Deliver enhanced process and product

sustainability

5

Biorefineries

Core

Industrial Biosciences

Developing customer-driven solutions that enhance value creation, reduce

environmental footprints, and improve health & wellness for end users

$50B addressable market consisting of: Animal nutrition, food, cleaning/

detergents, textiles, carpet, personal care, feedstock processing, biofuels

Our Business

Our Markets

Our Business

Segments

Bioactives = enzymes, peptides and performance proteins for

markets such as food, animal nutrition, detergents, textiles

Biomaterials = advanced materials and intermediates

manufactured with renewable feedstocks

Biorefineries = products and technology for converting

agricultural feedstocks into carbohydrates and fuels

6

Long-term growth targets: sales +10-12% CAGR with 15-17% margins

Who We Are And Where We Work

Industrial Biosciences

is comprised of more

than 2500 dedicated

colleagues worldwide

We discover and

develop market-based

biotechnology

solutions at 8 global

R&D sites

DuPont Industrial Biosciences

R&D sites

We produce a broad

portfolio of products

and manage 19

operations sites

Research & Development

Centers

Production, Operations and

Pilot Sites

7

2011E Sales: $0.7B*

Industrial Biosciences SalesServing Customers in Multiple Markets Around the World

Region Business Unit End Market

ApparelFood

Enzymes

Other

Latin

America

8

BioactivesBiomaterials

Biorefineries Animal

nutrition

Feedstock

processing

Detergent

enzymes

Carpet

US & Canada

EMEA

Asia

Pacific

* Segment sales include transfers.

Addressable Market:

$50 Billion 2011-2015E CAGR

Animal

Nutrition$1.5 B

Growing demand for protein in human diets

More efficient and sustainable animal

production

8 10%

Detergent

Enzymes$1 B

Rising affluence and demand for convenience

Water and energy conservation5 7%

Food$1 B

Natural and clean label7 9%

Industrial Biosciences MarketsKey Market Trends & Opportunities

MarketMarket Growth Drivers

Food

Enzymes$1 B

Natural and clean label

Improved processing and product shelf life7 9%

Renewable

Materials$20 B

Desire for performance and renewability claims

Supply diversification and stability in feedstocks2 7%

Biofuels $25+ B Energy supply diversification and environmental

concerns

Rural and green economy development7 12%

9

Feedstock / Aggregator Enzyme SupplierConversion EngineeringCatalysts / BiocatalystsApplication

Development

DuPont

DSM

Novozymes

Amyris

Gevo

Solazyme

Industry Capabilities Landscape

Solazyme

Abengoa

Poet BP

1

Shell

2

10

DuPont strongly positioned across key steps in

value chain

DuPont provides unique integrated offerings

Other participants range in breadth of offering

Narrow / specialist players must partner to

access market

1. Enzymes limited to cellulosic ethanol

2. Participation primarily through partnerships

Industrial Biosciences

Key R&D Programs

Customer Benefits / Opportunities R&D Phase

Su

sta

ina

bili

ty

Pro

du

ctiv

ity

He

alt

h &

we

llne

ss

Fee

dst

ock

div

ers

ific

ati

on

Sa

fety

an

d

Re

gu

lato

ry

Pe

tro

leu

m/

che

mic

al

rep

lace

me

nt

1 2 3 4 5

Lau

nch

Bioactives

Feed enzyme system: Axtra XAP

Omega-3

Cold water washing

Next generation feed enzyme

Biosurfaces

11

Biomaterials

Flame retardant fiber for carpet

Bio-THF

BioIsoprene

Biorefineries

Grain processing: Spezyme RSL

Cellulosic ethanol

Biobutanol

R&D Phases: 1-Discovery; 2-Concept validation; 3-Prototype;

4-Scale up; 5-Launch preparation

Bioactives

New Feed Enzyme SystemSpecifically designed to help US broiler producers meet the challenge of rising feed costs

Lower feed costs

Improved calorie conversion

More uniform birds

DuPont science delivers radical feed cost savings

More uniform birds

Proven value in antibiotic growth

promoter free nutrition

Demonstrated net feed costs

savings of at least $7 per ton (5%)

12

Biomaterials

BioIsoprene monomer

Provide significant raw material cost

savings vs. synthetic and natural

rubbers

Enable cost-competitive replacement

of natural rubber of natural rubber

Build platform to access multi-billion

dollar C5 chemical opportunity

Partner to produce isoprene monomer

for Goodyears polyisoprene process

Pilot plant construction target: 2012

13

Global Biofuels Market

Large and Growing Addressable Market

Production surpassed 28 B gallons in 2010

(3% of total road transport fuel)

More than 50 countries have enacted biofuel

targets/mandates -- expected to reach >45 B gallons by

2020, or >$100B market

Key drivers: energy independence; tech advancement

(green jobs); rural development; reduction of greenhouse

gases

Biofuel Demand by Type 2010-2050(Source: IEA 2010-11)

150

200

250

Ethanol conventional (corn)

Ethanol cane

Ethanol cellulosic

Biodiesel conventional

Biodiesel advanced

gases

Industry Challenges for Meeting Demand

Economies of scale and existing infrastructure still favor

fossil fuels

Acceptance of technology risk and capital intensity required

for capacity build-out

Policy stabilization and consistency are critical. Change or

uncertainty discourages investment

B g

als

2010 2050204020302020

50

100

150

Biojet

Biomethane

14

Cellulosic EthanolCommercialize lower-cost, lower-capital production technology for biofuels from non-food feedstocks

Operating demonstration scale

facility in Vonore, TN. Generating

data for scale up

2011 field stover harvest confirmed

economics for biomass deliveryeconomics for biomass delivery

Engineering and front-end loading

underway for Iowa site

Deployment strategy includes

commercial operations, licensing

model and merchant enzymes

Market/Customers

Biofuel producers

Refinery operators

15

Major Biorefinery Program Updates

Grain Processing BiobutanolCellulosic Ethanol

Today

Commercial business serving grain ethanol, sweeteners, and biochemicals industries

Demo facility in TN proving out commercial economics

2011 field stover harvest confirmed economics for biomass delivery

Commercial stover biorefinery site purchased in Iowa

JV demo facility in UK complete

Process units being commissioned for integrated operation

Negotiations in progress for first commercial partnerships

16

purchased in Iowa commercial partnerships

2012

2014

Continuous productivity increases f