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Industrial Biosciences Jim Collins - President

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Industrial BiosciencesJim Collins - President

Industrial Biosciences

Mission

Focused growth through bioprocessing technologies • Build on Genencor’s expertise in designing and operating cell factories

• Leverage Pioneer’s relationship with growers

• Apply DuPont’s capabilities in engineering and advanced materials

Intersection for innovation across DuPont’s competencies

Agriculture

and Nutrition

Industrial

BiosciencesAdvanced

Materials

2

Bioactives

Biomaterials

Key Segments in Our Business

Agriculture

and

Nutrition

Industrial

BiosciencesAdvanced

Materials

Bioactives Biomaterials

Bio-based products End use markets

Enzymes, proteins,

peptides

Food, feed, cleaning,

paper, personal care

Biorefineries: Biofuels

3

Biorefineries

Biochemicals

BiomaterialsCarpet, textiles

Ethanol

BiobutanolFuels

Bio-based Products End use markets

Bioactives

Biomaterials

Focused on Three Bio-based SegmentsServing a diverse set of customers

Enzymes, proteins,

peptides

Food, feed, cleaning,

paper, personal care

Sugars

Our Competitive Advantage

Carbon Sources Conversion

Starch

Biorefineries: Biofuels

4

Biochemicals

BiomaterialsCarpet, textiles

Ethanol

BiobutanolFuels

Bio/chemical transformation

Biomass

SugarsBio/chemical

transformation

Core Elements• Renewable, bio-based inputs

Based on Common Core Elements

Agriculture

and

Nutrition

Industrial

BiosciencesAdvanced

Materials

Bioactives Biomaterials• Renewable, bio-based inputs

• Design and operation of cell factories

• Deliver enhanced process and product

sustainability

5

Biorefineries

Core

Industrial Biosciences

Developing customer-driven solutions that enhance value creation, reduce

environmental footprints, and improve health & wellness for end users

$50B addressable market consisting of: Animal nutrition, food, cleaning/

detergents, textiles, carpet, personal care, feedstock processing, biofuels

Our Business

Our Markets

Our Business

Segments

Bioactives = enzymes, peptides and performance proteins for

markets such as food, animal nutrition, detergents, textiles

Biomaterials = advanced materials and intermediates

manufactured with renewable feedstocks

Biorefineries = products and technology for converting

agricultural feedstocks into carbohydrates and fuels

6

Long-term growth targets: sales +10-12% CAGR with 15-17% margins

Who We Are And Where We Work

• Industrial Biosciences

is comprised of more

than 2500 dedicated

colleagues worldwide

• We discover and

develop market-based

biotechnology

solutions at 8 global

R&D sites

DuPont Industrial Biosciences

R&D sites

• We produce a broad

portfolio of products

and manage 19

operations sites

Research & Development

Centers

Production, Operations and

Pilot Sites

7

2011E Sales: $0.7B*

Industrial Biosciences SalesServing Customers in Multiple Markets Around the World

Region Business Unit End Market

ApparelFood

Enzymes

Other

Latin

America

8

BioactivesBiomaterials

Biorefineries Animal

nutrition

Feedstock

processing

Detergent

enzymes

Carpet

US & Canada

EMEA

Asia

Pacific

* Segment sales include transfers.

Addressable Market:

$50 Billion 2011-2015E CAGR

Animal

Nutrition$1.5 B

• Growing demand for protein in human diets

• More efficient and sustainable animal

production

8 – 10%

Detergent

Enzymes$1 B

• Rising affluence and demand for convenience

• Water and energy conservation5 – 7%

Food$1 B

• Natural and “clean” label7 – 9%

Industrial Biosciences MarketsKey Market Trends & Opportunities

MarketMarket Growth Drivers

Food

Enzymes$1 B

• Natural and “clean” label

• Improved processing and product shelf life7 – 9%

Renewable

Materials$20 B

• Desire for performance and renewability claims

• Supply diversification and stability in feedstocks2 – 7%

Biofuels $25+ B• Energy supply diversification and environmental

concerns

• Rural and “green” economy development

7 – 12%

9

Feedstock / Aggregator Enzyme SupplierConversion EngineeringCatalysts / BiocatalystsApplication

Development

DuPont � � � � � �

DSM � � � �

Novozymes � �

Amyris �

Gevo � � �

Solazyme �

Industry Capabilities Landscape

Solazyme �

Abengoa � � �

Poet � � �BP

� � �1

� �Shell

2

� � � �

10

• DuPont strongly positioned across key steps in

value chain

• DuPont provides unique integrated offerings

• Other participants range in breadth of offering

• Narrow / specialist players must partner to

access market

1. Enzymes limited to cellulosic ethanol

2. Participation primarily through partnerships

Industrial Biosciences

Key R&D Programs

Customer Benefits / Opportunities R&D Phase

Su

sta

ina

bili

ty

Pro

du

ctiv

ity

He

alt

h &

we

llne

ss

Fee

dst

ock

div

ers

ific

ati

on

Sa

fety

an

d

Re

gu

lato

ry

Pe

tro

leu

m/

che

mic

al

rep

lace

me

nt

1 2 3 4 5

Lau

nch

Bioactives

Feed enzyme system: Axtra® XAP � � �

Omega-3 � �

Cold water washing � � � �

Next generation feed enzyme � � � � �

Biosurfaces � �

11

Biomaterials

Flame retardant fiber for carpet � � �

Bio-THF � � �

BioIsoprene™ � � � �

Biorefineries

Grain processing: Spezyme® RSL � � � �

Cellulosic ethanol � � � �

Biobutanol � � �

R&D Phases: 1-Discovery; 2-Concept validation; 3-Prototype;

4-Scale up; 5-Launch preparation

Bioactives

New Feed Enzyme SystemSpecifically designed to help US broiler producers meet the challenge of rising feed costs

• Lower feed costs

• Improved calorie conversion

• More uniform birds

DuPont science delivers radical feed cost savings

• More uniform birds

• Proven value in antibiotic growth

promoter free nutrition

• Demonstrated net feed costs

savings of at least $7 per ton (5%)

12

Biomaterials

BioIsoprene™ monomer

• Provide significant raw material cost

savings vs. synthetic and natural

rubbers

• Enable cost-competitive replacement

of natural rubber of natural rubber

• Build platform to access multi-billion

dollar C5 chemical opportunity

• Partner to produce isoprene monomer

for Goodyear’s polyisoprene process

• Pilot plant construction target: 2012

13

Global Biofuels Market

Large and Growing Addressable Market

Production surpassed 28 B gallons in 2010

(3% of total road transport fuel)

More than 50 countries have enacted biofuel

targets/mandates -- expected to reach >45 B gallons by

2020, or >$100B market

Key drivers: energy independence; tech advancement

(“green” jobs); rural development; reduction of greenhouse

gases

Biofuel Demand by Type 2010-2050(Source: IEA 2010-11)

150

200

250

Ethanol – conventional (corn)

Ethanol – cane

Ethanol – cellulosic

Biodiesel – conventional

Biodiesel – advanced

gases

Industry Challenges for Meeting Demand

Economies of scale and existing infrastructure still favor

fossil fuels

Acceptance of technology risk and capital intensity required

for capacity build-out

Policy stabilization and consistency are critical. Change or

uncertainty discourages investment

B g

als

2010 2050204020302020

50

100

150

Biojet

Biomethane

14

Cellulosic EthanolCommercialize lower-cost, lower-capital production technology for biofuels from non-food feedstocks

• Operating demonstration scale

facility in Vonore, TN. Generating

data for scale up

• 2011 field stover harvest confirmed

economics for biomass deliveryeconomics for biomass delivery

• Engineering and front-end loading

underway for Iowa site

• Deployment strategy includes

commercial operations, licensing

model and merchant enzymes

Market/Customers

Biofuel producers

Refinery operators

15

Major Biorefinery Program Updates

Grain Processing BiobutanolCellulosic Ethanol

Today

• Commercial business serving grain ethanol, sweeteners, and biochemicals industries

• Demo facility in TN proving out commercial economics

• 2011 field stover harvest confirmed economics for biomass delivery

• Commercial stover biorefinery site purchased in Iowa

• JV demo facility in UK complete

• Process units being commissioned for integrated operation

• Negotiations in progress for first commercial partnerships

16

purchased in Iowa commercial partnerships

2012

– 2014

• Continuous productivity increases for cost and efficiency improvements

• Expanded enzyme offerings and processing technology

• Commercial production

• Multiple licensees for process technology

• Expanded value offerings

• First ethanol plant conversion

• Commercial production of biobutanol

• Multiple licensees of biobutanol technology

2015

– 2020• Development of integrated

bioprocessing refinery• Additional offerings and technology

extensions• Additional offerings and technology

extensions

Driving Profitable Growth

Continuous Improvement• Changing the way the host strain

grows, lowers broth viscosity

• Frees up fermenter capacity

• Avoids additional capital

investment

Trichoderma grows in long

filaments resulting in a

highly viscous broth

Cell mass limited to a

fragmented, lower viscosity

form

Productivity• Cost discipline

• Integration synergies

• Capacity Release

- Optimization of cell factories

17

Industrial Biosciences

2012 and Long-term Priorities

• Deliver on Key Growth Opportunities

– Broaden portfolio through innovation and

application development

– Strong growth in developing markets

– Penetrate new market segments

– Launch new technologies for feedstock

processing

$0.7

10%

Sales and Margin Performance

18

– Commercialize biofuels

• PTOI Margin

– Capture integration synergies

– Scale up biofuel technology licensing

– Drive cost and capital productivity 2011E

Sales ($B)* Pre Tax Margins (%)**

* Segment sales include transfers.

* * Excludes significant items. Refer to company website for detailed

reconciliations of non-GAAP measures.

Long-term growth targets: sales +10-12% CAGR with 15-17% margins