Denis Hadjiliadis MD, MHS, FCCP, FRCP(C)

Paul F Harron Jr, Associate Professor of MedicineDivision of Pulmonary, Allergy and Critical,

Perelman School of Medicine, University of PennsylvaniaDirector, Adult Cystic Fibrosis Program Member, Lung Transplantation Program

Biography

• Denis Hadjiliadis did his undergraduate studies at McGill University in Montreal, Canada and completed his MD at the University of Toronto, in Canada in 1995.

• He subsequently pursued training in Internal Medicine at the Mayo Clinic and Pulmonary and Critical Care Medicine at Duke University, where he also completed a Master’s of Health Sciences in 2001. Further training was pursued in Lung Transplantation and Cystic Fibrosis at the University of Toronto, completed in 2002.

• He joined the faculty at the University of Toronto in 2001 as an instructor and as Assistant Professor in 2003, where he was also the Medical Director of the B4 hospitalist unit (included chronic ventilators).

Biography

• He joined the University of Pennsylvania in 2005 as the Associate Medical Director of the Lung Transplant Program (a position he stepped down from in 2012, but he remains an active member).

• He has been the Adult Program Director of the Cystic Fibrosis Program since 2009 and the local Principal Investigator for the Cystic Fibrosis Therapeutic and Development Network and the medical lead for the Advanced Lung Disease Clinical Research group.

• He is currently the Paul F Harron Jr Associate Professor of Medicine, at the Perelman School of Medicine of the University of Pennsylvania.

Biography

• Dr Hadjiliadis has a very active practice in one of the largest Adult Cystic Fibrosis Programs in the country and also manages patients before and after lung transplantation, mainly with cystic fibrosis. He also sees patients with bronchiectasis

• He is part of multidisciplinary teams in treating all the above conditions and is very experienced in providing multidisciplinary care

• He is involved in the education of medical students, residents, fellows and allied health professionals (including nurses and nurse practitioners) in many ways including, clinical teaching, didactic lectures and small group sessions

Biography

• He has been the local PI for many clinical trials mainly in the disease areas of CF and bronchiectasis, including antibiotic and anti-inflammatory trials for these diseases (inhaled aztreonam, levofloxacin, ciprofloxacin and vancomycin are some of the agents studied)

• He also has been involved in many investigator initiated clinical trials in areas of susceptibility to Pseudomonas infection, inspiratory muscle strength and training in CF, use of flaxseed in CF and many others, some of them as a PI and others as a collaborating physician

Research interests

• Susceptibility of CF patients to Pseudomonas acquisition

• Prediction of outcomes in patients with advanced CF requiring lung transplantation

• Variation of CF mucous and lung disease during menstrual cycle

• Inspiratory muscle strength in patients with CF; implications for prediction of weakness and training

Research interests

• CF related diabetes; pathogenesis and mechanisms of progression as well as treatment

• Anti-inflammatory and anti-oxidant diet, in patients with CF, more specifically flaxseed

• Pregnancy in cystic fibrosis

• New CF modifier treatments in patients with rare mutations

Research interests

• Transition of care of young adults with CF from pediatric to adult hospitals

• Use of voriconazole after lung transplant • Development of immunity against wild-type CFTR in aptients

with CF

Selected references

• Martine Loeve, Wim C. J. Hop, Marleen de Bruijne, Peter Th. W. van Hal, Phil Robinson, Moira L. Aitken, Jonathan D. Dodd, Harm A. W. M. Tiddens, on behalf of the Computed Tomography Cystic Fibrosis Survival study group: Chest Computed Tomography scores are predictive of survival in CF patients awaiting lung transplantation. American Journal of Respiratory and Critical Care Medicine 2012 Notes: I am part of the Cystic Fibrosis CT Survival Study Group.

• Rebecca E. Colman; J. Randall Curtis; Judith E. Nelson; Linda Efferen; Denis Hadjiliadis;

Deborah J. Levine; Keith C. Meyer; Maria Padilla; Mary Strek; Basil Varkey; Lianne G. Singer: Barriers to Optimal Palliative Care of Lung Transplant Candidates. Chest Page: doi:10.1378/chest.12-0830, 2012 Notes: online first.

• Lipson David A, Holsclaw Douglas, Imbesi Giovanna, Ferrin Marianne, Sims Michael, Miller

Sam, Tal-Singer Ruth, Hadjiliadis Denis2: Evidence of Elevated CXCR2 Agonists in Stable Outpatients with Cystic Fibrosis Compared with Healthy Controls. Journal of Pulmonary and Respiratory Medicine 3: 149, 2013.

Selected references

• Monica Ahluwalia, Jeffrey B. Hoag, Anas Hadeh, Marianne Ferrin, Denis Hadjiliadis:

Cystic fibrosis and pregnancy in the modern era: A case control study. Journal of Cystic Fibrosis 2013.

• Kreider ME, Hadjiliadis D, Kotloff RM: Candidate Selection, Timing of Listing, and Choice of Procedure for Lung Transplantation Clinics in Chest Medicine 32(2): 199-211, Jun 2011 Notes: Accepted for publication.

• Mogayzel PJ Jr. Naureckas ET. Robinson KA. Mueller G. Hadjiliadis D. Hoag JB.

Lubsch L. Hazle L. Sabadosa K. Marshall B. Pulmonary Clinical Practice Guidelines Committee.: Cystic fibrosis pulmonary guidelines. Chronic medications for maintenance of lung health. American Journal of Respiratory and Critical Care Medicine 187(7): 680-9, April 2013.

Selected references

• Hadjiliadis D: Why should we bother diagnosing cystic fibrosis in adult patients? Journal of Pulmonary and Respiratory Medicine(1), e102, 2011.

• Morales P, Santos M, Hadjiliadis D, Aris RM: Mycobacterial Infections in

Cardiothoracic Transplantation Diagnosis and Management of Infectious Diseases in Cardiothoracic Transplantation and Mechanical Circulatory Support. Martha L. Mooney, Margaret M. Hannan,and Shahid Husain (eds.). International Society for Heart and Lung Transplantation, Page: 161-173, 2011.

• Hadjiliadis D: Expert Commentary for "A CFTR potentiator in patients with cystic

fibrosis and the G551D mutation" N Engl J Med. 2011;365:1663-72. ACP Journal Club, 2012.

• • Hadjiliadis D: Are Macrolides the Pulmonologists' "Statin"? Journal of Pulmonary

and Respiratory Medicine