DepartmentofChemical,Biological&PharmaceuticalEngineeringNewJerseyCenterforEngineeredParticulates(NJCEP)&Particle

EngineeringLaboratoryResearchInfrastructure

1

ResearchAreas

EnhancementviaDry-coating§  Enhanceddirectcompression§  Betterpowderflow,

compactability,andfluidizability§  Improveddry/wet

redispersibilityanddissolution§  Taste-masking§  Controlled/delayedrelease

Modeling§  Populationbalancemodel§  Discreteelementmodel§  Microhydrodynamicmodels§  Multi-scalemodels§  Dryingmodels

PoorlySolubleDrugs§  Particulate-basedsystems:

Nanoparticles,Microparticles,CoatedMicroparticles

§  NanosuspensionsandNanocomposites§  Stripfilms§  Amorphoussoliddispersions:Spraydrying,Impregnationwithmeso-

porouscarriers,Amorphizationviadrymilling

PharmaceuticalProcessing§  Fluidizedbeddrying/coating/granulation§  Spraydrying§  Blendinganddrymilling§  Drycoating§  ContinuousprocessingandPAT§  Solventcasting/drying§  Liquidantisolventprecipitation§  Wetstirredmediamilling§  Supercriticalfluidprocessing

3

Facilities and Laboratories

Facilities:NewJerseyCenterforEngineeredParticulates(NJCEP)Labs

Tiernan-310§  Dryparticlecharacterization§  Particlemixing

York-203§  Particlecharacterization(size,

NIR)§  Opticalimaging§  Particlesurfacecharacterization§  Surfacedissolutionimaging

Facilities:NewJerseyCenterforEngineeredParticulates(NJCEP)Labs

York-205§  Drycoating,sieving§  Supercriticalfluidprocessing§  Drying§  Amorphousstability

York-207§  Drycoating§  Fluidizedbeddrying/coating/

granulation§  Tabletting§  Wetstirredmediamilling§  Textureanalysis

Facilities:NewJerseyCenterforEngineeredParticulates(NJCEP)Labs

York-103§  Filmcasting§  Dissolutiontestingforfilms,

tablets,andcomposites§  Mixing§  Liquidantisolventcrystallization

York-B5§  Powdercharacterization(FT4,

AOR)§  Drymilling/coating(FEM)§  Mixing

Facilities:ParticleEngineeringLaboratory

York-105§  Nanoparticlesviawetstirredmediamillingandmeltemulsification§  Spraydryingfornanocompositesandamorphoussoliddispersions§  Particlesizingvialaserdiffraction,thermalanalysis(TGA,DSC)§  Suspensioncharacterization(rheology,surfacetension)

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Processing Equipment

Dry Coating, Dry Milling, and Simultaneous Dry Coating/Milling

MAIC§  Surfacemodificationanddrycoating

QuadroComil§  Continuousdrycoating,drymilling/coating

FluidEnergyMill§  Drymilling/coatingofparticles

LabRam§  Drycoating/mixing

Wet Milling: Stirred Media Mill, Attrition Mill, Vibratory Mill

MicrosBatchMill§  Nano/micro-particlesuspensionformation(in

eitherattritionmodeorstirredmediamode)NetzschMicrocerRecicrulationMill

§  Nano/micro-particlesuspensionformation

LabRam§  Wetvibratorymillingwithmillingmedia

Spray Drying and Encapsulation, Wet Coating and Granulation

BuchiMiniSprayDryer§  Nanocompositesproduction§  Amorphoussoliddispersions§  Encapsulation,tastemasking

ProceptSprayDryer§  Nanocompositesproduction§  Amorphoussoliddispersions§  Encapsulation,tastemasking

MiniGlattFBCoater§  Nanocomposites(~15-800µmcarrier)production§  Tastemasking/controlledreleaseviapolymer

coating

Strip-Film Production

HEDFilmCastingLine§  BCSclassIIdrugdeliveryplatform§  Fastdissolvingfilms§  Controlledrelease§  Multilayeredfilms

Convective/MicrowaveDrier§  FilmcastingviaconvectionandIR

heating

Miscellaneous Processing Equipment (I)

SieveShaker§  Particlesizescreening§  Narrowsievecut

preparation

SupercriticalFluidSystem§  Nano/microparticleformationviasupercritical

fluidprocessing

CarverTabletPress§  Tabletmaking

Miscellaneous Processing Equipment (II)

SonicationProbes§  Anti-solventcrystallization,meltemulsification

PattersonKelleyV-Blender§  Powdermixing

Microclimate§  ControlledRH/Tforphysicalstability

testing

Hybridizer§  Drycoating

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Characterization Equipment

Particle/Droplet Size Distribution

Beckman-LS13320ParticleSizeAnalyzer§  Particlesizeanalysisbasedonlaser

diffraction(~40nm-2000µm)

DelsaNanoC§  Zetapotentialandsubmicronparticlesizeanalysis

basedonelectrophoresisanddynamiclightscattering

MalvernSpraytecLaserDiffractionSystem•  Measurementofparticlesizeinaerosoland

dropletsizeinsprays

MicronAir‑JetSieve§  Sizingbyair-jetsieving SieveShaker

§  Sizingbysieving

Powder Characterization Equipment (1)

HosokawaPowderTester§  Angleofrepose

FT4PowderTester§  Flowproperties(FFC)andbulkdensity

measurement

IGCSEAsurfaceenergyanalysis§  InverseGasChromatography(IGC)

surfaceenergymeasurement

SotaxTd1§  Tapdensitytester

Powder Characterization Equipment (2)

SympatecRodos-Helos§  Dryparticlesizeanalysisbased

onlaserdiffraction

Flowdex§  Powderflowabilitytester

www.sympatec.com

www.jbpharmatron.com

Solid-State/Thermal/Mechanical Characterization

TGA/DSC1/SFStaresystem§  Thermogravimetricanalysis(TGA)

TA-XTPlusTextureAnalyzer§  Mechanicaltestingoffilms

PolymerDSC,TGA/DSC1/SFStaresystem§  Differentialscanningcalorimetry(DSC).

KeyenceVH-2500§  Digitalopticalmicroscope

Suspension Characterization

Attensionopticaltensiometer§  Surfacetensionmeasurement§  Wettability§  Liquidpenetrationinto

powderbeds

Brookfieldviscometer§  Apparentshearviscosity

Dissolution/Disintegration Testing

SOTAXAT7SmartDissolutionSystem§  Drugreleaseduringdissolution(automated

sampling)

DT2ManualDisintegrationTester§  Tabletdisintegrationtesting

Distek2100CUSPIIApparatus§  Drugreleaseduringdissolution(manual

sampling)

SotaxCE7smart§  Flow-throughdissolution(automatedsampling)

Drug/Moisture Content Quantification

EvolutionTM60S§  UV–visiblespectrophotometer

SiriusSDI(SurfaceDissolutionImager)§  RealtimeUVimagingsystem MettlerCompactKarlFisherCoulometer,C30

§  Determinationofmoisturecontent

Waters2695SeparationModule§  DrugassayquantificationbyHPLC

Sample Preparation Equipment

THINKYMixer§  PlanetaryCentrifugal

mixing

BransonB1510§  UltrasoniccleanerFisherVortexMixer

§  Vortexmixing

IKARO15§  Magneticstirrer

SP-230GilsonSpinningRiffler§  Spinningrifflingofpowder

Additional Facility and Equipment

Nominalfee-basedaccesstoMaterialsCharacterizationLaboratory(MCL)atNJIT,whichhousesthefollowingmajorequipment:§  Scanningelectronmicroscopy(SEM)withelementalmapping

§  PowderX-Raydiffraction(PXRD)§  BETsurfacearea,poresizedistribution§  Inductivelycoupledplasmamassspectroscopy(ICP-MS)§  Scanningprobemicroscope/atomicforcemicroscope(SPM/AFM)

§  FourierTransformInfrared(FTIR)Spectrometer§  Gaschromatography(GC)§  Miscellaneouscharacterizationequipment