DermatopathologyDermatopathologySlide ReviewSlide Review--22

Paul K. Shitabata, M.D.Paul K. Shitabata, M.D.DermatopathologistDermatopathologist

Pathology Inc.Pathology Inc.

Fixed Drug EruptionFixed Drug Eruption

HistopathologyHistopathology

LichenoidLichenoid interface interface dermatitisdermatitisSPDSPDHemorrhageHemorrhage

PityriasisPityriasis RubraRubra PilarisPilaris

HistopathologyHistopathology

PsoriasiformPsoriasiform dermatitisdermatitisAlternating OK/PK in Alternating OK/PK in horizontal/vertical horizontal/vertical Follicular pluggingFollicular pluggingRarely Rarely acantholysisacantholysis

LepromatousLepromatous LeprosyLeprosy

HistopathologyHistopathology

Dependent upon Dependent upon immune statusimmune statusNonNon--caseatingcaseating sarcoidalsarcoidaltype type granulomasgranulomasScant chronic Scant chronic inflammatory infiltrateinflammatory infiltrateFoamy Foamy histiocyteshistiocytesFiteFite vs. AFvs. AF

Lupus Lupus ErythematosusErythematosus

HistopathologyHistopathology

Follicular pluggingFollicular pluggingEpidermal atrophyEpidermal atrophyInterface dermatitisInterface dermatitisSDPVSDPVDermal Dermal mucinosismucinosis

Gouty Gouty TophusTophus

HistopathologyHistopathology

PalisadingPalisading granulomasgranulomaswith giant cellswith giant cellsAmorphous Amorphous amphophilicamphophiliccrystalscrystalsCalcifciationsCalcifciations

Balloon Cell NevusBalloon Cell Nevus

HistopathologyHistopathology

Ballooning or clearing of Ballooning or clearing of cytoplasm cytoplasm of of melanocytesmelanocytesBenign to malignant Benign to malignant changeschanges

XanthelasmaXanthelasma

HistopathologyHistopathology

Foamy Foamy histiocyteshistiocytesNo No atypiaatypia