designing a better antimycobacterial

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esignlng a better antim cobacterial RESEARCH & DEVELOPMENT French and Gennan re archers ha e foun what th y belie e i the main hydrophilic pathway lhrough the cell wall of Mycobacterium chelonae. repons Science. They identified a 59 kilodalton cell wall protein that ac a a porin, fonning a water-filled channel for diffu ion of compound in and out of the cell. A better under landing of thi porin y tern rna improve antiba lerial d ign. leading to agent able to overcome the permeability barrier of the mycobacterium cell wall. ISSN 0156-270319310116-0091$1.0(/> Adl. International Ltd 9 INPHARMA" 16 Jan 1993

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Page 1: Designing a better antimycobacterial

esignlng a better antim cobacterial

RESEARCH & DEVELOPMENT

French and Gennan re archers ha e foun what th y belie e i the main hydrophilic pathway lhrough the cell wall of Mycobacterium chelonae. repons Science.

They identified a 59 kilodalton cell wall protein that ac a a porin, fonning a water-filled channel for diffu ion of compound in and out of the cell. A better under landing of thi porin y tern rna improve antiba lerial d ign. leading to agent able to overcome the permeability barrier of the mycobacterium cell wall.

ISSN 0156-270319310116-0091$1.0(/> Adl. International Ltd

9

INPHARMA" 16 Jan 1993