detecting and treating asparaginase-related toxicities in acute lymphoblastic leukemia
DESCRIPTION
Detecting and Treating Asparaginase-Related Toxicities in Acute Lymphoblastic Leukemia. Activity Goals. Acute Lymphoblastic Leukemia (ALL). Outcome: Adults vs Childhood ALL . PEG-asparaginase for Pediatric Patients. Retrospective Comparison of Adult vs Pediatric Protocols. - PowerPoint PPT PresentationTRANSCRIPT
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Detecting and Treating Asparaginase-Related Toxicities
in Acute Lymphoblastic Leukemia
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Activity Goals
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Acute Lymphoblastic Leukemia (ALL)
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Outcome: Adults vs Childhood ALL
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PEG-asparaginase for Pediatric Patients
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Retrospective Comparison of Adult vs Pediatric Protocols
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Comparison of Adverse Events During Induction
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Serum Asparaginase Concentrations
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Grades 2-4 PEG-asparaginase-Related Adverse Events in Adults
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PEG-asparaginase in Modified Pediatric Protocol
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PK of Dex and Asparaginase Activity
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Asparaginase Formulations and Half-life
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PEGylated Asparaginase
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Asparaginase
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Current Dosing of Asparaginase
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AEs From PEG-asparaginase From the CCG-Augmented
Pediatric BFM Protocol
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Asparaginase Hypersensitivity
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AEs to PEG-asparaginase in Adults
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Thrombosis
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Antibodies to PEG-asparaginase
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Measuring Asparaginase Activity
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Monitoring Serum Asparaginase Activity
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Dosing Asparaginase based on Serum Levels
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Presence of Neutralizing Antibody: Switch to Erwinia Asparaginase
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Why Use Asparaginase?
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Using Pediatric-inspired Approaches in Adult ALL
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The Importance of Asparaginase for ALL
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Management of Asparaginase Toxicity in Adults
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Conclusions
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Abbreviations
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Abbreviations (cont)
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References
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)