developmental stage-specific biphasic roles of wnt signaling in cardiomyogenesis and hematopoiesis...
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Developmental stage-specific biphasic roles of Developmental stage-specific biphasic roles of WntWnt signaling signaling
in cardiomyogenesis and hematopoiesisin cardiomyogenesis and hematopoiesis
(Atsuhiko T. Naito et al, 2006, Development)
Wnt signalings in embryonic development
Members of the Wnt and Tgfβ/Bmp families play critical roles in anterior-posterior patterning
(Yamaguchi TP, 2001, Curr Biol)
Zygotically expressed wnt8 may be involved in specifying or patterning ventral mesoderm.
(Gregory M Kelly, 1995, Development)
Interactions between Wnt and Vg1 signalling pathways initiate primitivestreak formation in the chick embryo
(Isaac skromne, 2001, Development)
Wnt signaling AP Axis patterning, primitive streak formation, mesoderm induction
Many controversies about Wnt signaling in heart formation
In chick embryo, Wnt signals from the neural tube block ectopic cardiogenesis
(Eldad Tzahor, 2001, Genes & Dev)
Dkk-1 can induce heart-specific gene expression in noncardiogenic mesoderm of Xenopus laevis
(Valerie A., 2000, Genes & Dev)
Overexpression of Wg using heat shock promoter increases the amount of heart formation in Drosophila
(Maiyon Park, 1996, Dev Biol)
Heart development in Drosophila requires the segment polarity gene wingless(Wg).
(Wu X, 1995, Dev Biol)
(Eldad Tzahor, 2001, Genes & Dev)
Overexpression of Wnt-1, 3 causes on reduction of cardiomyocyte
In chick embryo
Overexpression of Wg causes on abundance of cardiomyocyte
In gastrula of Drosophila
about a fourfold increase of heart precusor cell occurs in hswg embryos upon heat-shock for 30min at 37.5℃
(Park M, 1996, Dev Biol)