differential gene expression between han chinese and japanese
DESCRIPTION
Differential Gene Expression between Han Chinese and Japanese. Yuan Yuan Prof . Shuhua Xu’s group Population genomic group PICB. Chinese and Japanese are very similar in phenotype. Expression variation among Chinese and Japanese individuals. - PowerPoint PPT PresentationTRANSCRIPT
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Differential Gene Expression between Han Chinese and Japanese
Yuan YuanProf. Shuhua Xu’s group
Population genomic groupPICB
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Chinese and Japanese are very similar in phenotype.
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Expression variation among Chinese and Japanese individuals
Differentlyexpressed
Illumina's commercial whole genome expression array, Sentrix Human-6 Expression BeadChip version 2 These arrays utilize a bead pool with ~48,000 unique bead types Each with several hundred thousand gene-specific 50mer probes attached.
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Genome locations of 768 DE genes
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Functional enrichment of 768 DE genes
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Identify local (Cis) and distant (Trans) genetic regulators that associate with gene expression difference
Population
Cis: # genes(snps)
Trans: # genes(snps)
CHB 39 (306) 271 (4544)
JPT 68 (648) 92 (1216)
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Distribution of cis-associations(SNPs) relative to the transcription start site (TSS)
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Genetic contributions to total expression variation for 11 cis-genes
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Cis-gene vs GWAS trait
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CTSS vs cis-SNPs
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Acknowledgment
Dr. Shuhua Xu
Yang ling, Lu dongsheng, Shi meng, Lou haiyi
Jin wenfei, Pankaj
All in population genomics group