diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet...
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![Page 1: Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying](https://reader035.vdocuments.net/reader035/viewer/2022062308/56649d145503460f949e9179/html5/thumbnails/1.jpg)
Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet
coupling
by Reghan J. Hill, and Chih-Ying Wang
Proceedings AVolume 470(2167):20130843
July 8, 2014
©2014 by The Royal Society
![Page 2: Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying](https://reader035.vdocuments.net/reader035/viewer/2022062308/56649d145503460f949e9179/html5/thumbnails/2.jpg)
Scaled mobility 4πηmh|U/F| versus scaled tracer radius Λ=aη/(ηmh) for cylindrical tracers that span the full width of freely supported (upper) and hydrogel-supported (lower) membranes:
circles are numerically exact calculations according to Wang & Hill [12]...
Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843
©2014 by The Royal Society
![Page 3: Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying](https://reader035.vdocuments.net/reader035/viewer/2022062308/56649d145503460f949e9179/html5/thumbnails/3.jpg)
(a) Membrane tracers embedded in solid-supported phospholipid bilayers.
Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843
©2014 by The Royal Society
![Page 4: Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying](https://reader035.vdocuments.net/reader035/viewer/2022062308/56649d145503460f949e9179/html5/thumbnails/4.jpg)
(a) Scaled proximal mobility fp=4πηmh/γ versus scaled inter-leaflet friction coefficient ϵ12 for several values of the scaled proximal-leaflet friction coefficient (proximal configuration)
ϵ2=0.001, 0.002, 0.004, 0.01, 0.02, 0.04, 0.1, 0.2, 0.4, 1, 2, 4, 8 ...
Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843
©2014 by The Royal Society
![Page 5: Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying](https://reader035.vdocuments.net/reader035/viewer/2022062308/56649d145503460f949e9179/html5/thumbnails/5.jpg)
(a) Scaled proximal mobility fp=4πηmh/γ versus scaled particle size ϵ2 for several values of the inter-leaflet friction coefficient (proximal configuration) ϵ12/ϵ2=1, 4, 16, 64 (top to bottom):
ϵ1/ϵ2=10−4, ϵtm/ϵ12=1, ϵtw/ϵ2=1.
Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843
©2014 by The Royal Society
![Page 6: Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying](https://reader035.vdocuments.net/reader035/viewer/2022062308/56649d145503460f949e9179/html5/thumbnails/6.jpg)
(a) Scaled proximal mobility fp=4πηmh/γ versus scaled particle size ϵ2 for several values of the inter-leaflet friction coefficient (proximal configuration) ϵ12/ϵ2=0.001, 0.1, 10 (top to bottom):
ϵ1/ϵ2=10−4, ϵtm=10, ϵtw/ϵ2=1.
Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843
©2014 by The Royal Society
![Page 7: Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying](https://reader035.vdocuments.net/reader035/viewer/2022062308/56649d145503460f949e9179/html5/thumbnails/7.jpg)
(a) Scaled proximal mobility fp=4πηmh/γ versus scaled tracer–leaflet friction coefficient ϵtm/ϵ12 for several values of the scaled particle size ϵ2=0.001, 0.002, 0.004, 0.01, 0.02, 0.04, 0.1, 0.2, 0.4, 1,
2, 4 (top to bottom): ϵ1/ϵ2=10−4 (proximal configura...
Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843
©2014 by The Royal Society
![Page 8: Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying](https://reader035.vdocuments.net/reader035/viewer/2022062308/56649d145503460f949e9179/html5/thumbnails/8.jpg)
Membrane streamlines and velocity profiles (proximal configuration) according to the dual-leaflet model: ϵ1=10−4, ϵ2=2, ϵ12=1, ϵtm=ϵ12, ϵtw=ϵ2.
Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843
©2014 by The Royal Society
![Page 9: Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying](https://reader035.vdocuments.net/reader035/viewer/2022062308/56649d145503460f949e9179/html5/thumbnails/9.jpg)
(a) Membrane streamlines and velocity profiles (proximal configuration) according to the dual-leaflet model: ϵ1=10−4, ϵ2=2, ϵ12=0.01, ϵtm=10, ϵtw=ϵ2.
Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843
©2014 by The Royal Society
![Page 10: Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying](https://reader035.vdocuments.net/reader035/viewer/2022062308/56649d145503460f949e9179/html5/thumbnails/10.jpg)
Theoretical predictions of dimensional lipid diffusion coefficients: effects of tracer–leaflet (a), leaflet–leaflet (b) and leaflet–wall (c) coupling.
Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843
©2014 by The Royal Society