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    DIGESTIVE SYSTEM

    By Arvina D W

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    Food and Nutrition

    A. Food and Energy

    B. Nutrients

    1. Water

    2. Carbohydrates3. Fats

    4. Proteins

    5. Vitamins

    6. Minerals

    C. Nutrition and a Balanced Diet

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    NUTRIENTS

    include

    include

    such as such as

    are made of include includeare made using

    Nutrients

    Carbohydrates Fats MineralsProteins Vitamins

    Simple Complex

    Amino

    acids Calcium Iron

    Fatty Acids Glycerol

    Sugars Starches Fat-solubleWater-

    soluble

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    Body mass index

    Body mass index (kg/m2) = Weight (kg) / Height (m

    2)

    Female (kg/m2) Male (kg/m2)

    Thin < 17 (kg/m2

    ) < 18 (kg/m2

    )

    Normal 17 23 (kg/m2) 18 25 (kg/m2)

    Fat 23 27 (kg/m2) 25 27 (kg/m2)

    Obesity > 27 (kg/m2) > 27 (kg/m2)

    Source : Health Department 2003 See food intake and body weight

    http://g/digestion%20for%20sf-usi/Fundamental%20digestive%202/PREGASTRIC%20DIGESTION/foodintake.htmlhttp://g/digestion%20for%20sf-usi/Fundamental%20digestive%202/PREGASTRIC%20DIGESTION/foodintake.html
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    Carbohydrates

    Carbohydrates

    The diversity of dietary carbohydrates necessitates discussion

    of several classes of these molecules, ranging from simple

    sugars to huge, branched polymers

    Monosaccharides or simple sugars are either hexoses (6-carbon) like glucose,

    galactose and fructose, or pentoses (5-carbon) like ribose. These are the

    breakdown products of more complex carbohydrates and can be efficiently absorbedacross the wall of the digestive tube and transported into blood.

    Disaccharides are simply twomonosaccharides linked together by a glycosidic bond. The

    disaccharides most important in nutrition and digestion are:

    lactose or "milk sugar": glucose + galactose

    sucrose or "table sugar": glucose + fructose

    maltose: glucose + glucose

    Oligosaccharides, which include disaccharides, are relatively short chains of monosaccharides

    which typically are intermediates in the breakdown of polysaccharides to monosaccharides.

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    Polysaccharides

    You should be familiar with three important polysaccharides, each of which is a large polymer of

    glucose:

    Starch is a major plant storage form of glucose.Cellulose is the other major plant carbohydrate. It is the major constituent of plant cell walls,

    and more than half of the organic carbon on earth is found in cellulose. Herbivores subsist

    largely on cellulose, not because they can digest it themselves, but because their digestive tracts

    teem with microbes that produce cellulases that hydrolyze cellulose.

    Glycogen is the third large polymer of glucose and is the major animal storage carbohydrate.

    Like starch, the glucose molecules in glycogen are linked together by alpha(1-4) glycosidic

    bonds.

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    Fatty acids are present in only small amounts in animal and plant tissues, but are the building

    blocks of many important complex lipids. True fatty acids possess a long hydrocarbon chain

    terminating in a carboxyl group. Nearly all fatty acids have an even number of carbons and havechains between 14 and 22 carbons in length. The principle differences among the many fatty acids

    are the length of the chain (usually 16 or 18 carbons) and the positions of unsaturated or double

    bonds. For example, stearic acid (pictured below) has 18 carbons and is saturated.

    The so-called "short-chain" or volatile fatty acids are 2 to 4-carbon molecules of great importance

    in intermediary metabolism and as the mainstay of ruminant nutrition. They are represented by acetic,

    butyric and proprionic acids.

    The most abundant storage form of fat in animals and plants, and hence the most important dietary

    lipid, is neutral fat or triglyceride. A molecule of triglyceride is composed of a molecule of glycerol in

    which each of the three carbons is linked through an ester bond to a fatty acid. Triglycerides cannot

    be efficiently absorbed, and are enzymatically digested by pancreatic lipase into a 2-monoglyceride

    and two free fatty acids, all of which can be absorbed. Other lipases hydrolyse a triglyceride into

    glycerol and three fatty acids.

    A triglyceride

    (triacylglycerol):

    tristearin

    FATS

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    PROTEIN

    ProteinsProteins are polymers of amino acids linked together by peptide bonds. Very short proteins,

    typically 3 to 10 amino acids in length, are called peptides

    Although very small peptides can be absorbed to a limited degree, for all intents and purposes,

    proteins must be reduced to single amino acids before they can be absorbed. Enzymes that

    hydrolyze peptide bonds and reduce proteins or peptides to amino acids are calledproteases orpeptidases.

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    VITAMINS

    Vitamin

    A (retinol)

    D (calciferol)

    E (tocopherol)

    K

    B1 (thiamine)

    B2 (riboflavin)

    Sources

    Yellow, orange, and dark green

    vegetables; dairy products

    Fish oils, eggs; made by skin

    when exposed to sunlight;added to dairy products

    Green leafy vegetables, seeds,

    vegetable oils

    Green leafy vegetables; made

    by bacteria that live in human

    intestine

    Whole grains, pork, legumes,

    milk

    Dairy products, meats,

    vegetables, whole-grain cereal

    Function

    Important for growth of skin

    cells; important for night vision

    Promotes bone growth;

    increases calcium andphosphorus absorption

    Antioxidant; prevents cellular

    damage

    Needed for normal blood

    clotting

    Normal metabolism of

    carbohydrates

    Normal growth; part of electron

    transport chain; energy

    metabolism

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    VITAMINS

    Vitamin

    Niacin

    B6 (pyridoxine)

    Pantothenic acid

    Folic acid

    B12(cyanocobalamin)

    Sources

    Liver, milk, whole grains, nuts,

    meats, legumes

    Whole grains, meats,

    vegetables

    Meats, dairy, whole grains

    Legumes, nuts, green leafy

    vegetables, oranges, broccoli,

    peas, fortified bread and cereal

    Meats, eggs, dairy products,enriched cereals

    Function

    Important in energy metabolism

    Important for amino acid

    metabolism

    Needed for energy metabolism

    Coenzyme involved in nucleic

    acid metabolism; prevents

    neural-tube defects in

    developing fetuses

    Coenzyme in nucleic acidmetabolism; maturation of red

    blood cells

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    MINERALS

    Mineral

    Calcium

    Phosphorus

    Potassium

    Chlorine

    Sodium

    Magnesium

    Iron

    Fluorine

    Iodine

    Zinc

    Sources

    Diary products; salmon; sardines;

    kale; tofu; collard greens; legumes

    Dairy products; meats; poultry; grains

    Meats; dairy products; many

    fruits and vegetables; grains

    Table salt; processed foods

    Table salt; processed foods

    Whole grains; green leafy vegetables

    Meats; eggs; legumes; whole grains;

    green leafy vegetables; dried fruitFluoridated drinking water; tea;

    seafood

    Seafood; dairy products; iodized salt

    Meats; seafood; grains

    Function

    Bone and tooth formation; blood clotting;

    nerve and muscle function

    Bone and tooth formation; acid-base balance

    Acid-base balance; body water balance;

    nerve function

    Acid-base balance; formation of gastric juice

    Acid-base balance; body water balance;

    nerve function

    Activation of enzymes in protein synthesis

    Component of hemoglobin and of electron

    carriers used in energy metabolismMaintenance of tooth structure; maintenance

    of bone structure

    Component of thyroid hormones

    Component of certain digestive enzymes

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    FOOD GUIDE PYRAMID

    Fats

    Sugars

    Fats, Oils, and Sweets (use sparingly)Soft drinks, candy, ice cream, mayonnaise, and

    other foods in this group have relatively few

    valuable nutrients.

    Milk, Yogurt, and Cheese Group

    (2-3 Servings)Milk and other dairy products are rich in

    proteins, carbohydrates, vitamins, and

    minerals.

    Meat, Poultry, Fish, Dry Beans, Eggs,and Nut Group

    (2-3 servings)

    These foods are high in protein.

    They also supply vitamins and minerals.

    Vegetable Group

    (3-5 servings)

    Vegetables are a low-fat

    source of carbohydrates,

    fiber, vitamins, and minerals.

    Fruit Group

    (2-4 servings)

    Fruits are good sources of

    carbohydrates, fiber, vitaminsand water.

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    The Process of Digestion

    A. The Mouth

    1. Teeth (Mechanical Digestion )

    2. Saliva (Chemical Digestion)

    B. The Esophagus

    C. The Stomach

    1. Chemical Digestion2. Mechanical Digestion

    D. The Small Intestine

    E. Absorption in the Small Intestine

    F. The Large Intestine

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    THE ORGANS OF DIGESTIVE SYSTEM

    Pharynx

    Mouth

    Salivary glands

    Esophagus

    Liver

    Gallbladder(behind liver)

    Rectum

    Stomach

    Pancreas(behind stomach)

    Large intestine

    Small intestine

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    PREGASTRIC DIGESTION

    There are 3 stages to provide food for the gut to work on in the mouth:

    1.Prehension the process of seizing or grasping or otherwise getting food into the

    mouth.

    2.Mastication the first step in the breakdown of complex foodstuffs and serves several

    functions, including:

    a. breaking large pieces into small pieces, resulting in a massive increase in

    surface area which is where digestive enzymes work

    b. softening of food and transformation into a size conducive to swallowing

    c. lubrication of food by impregnating it with saliva

    3.Swallowing the bolus is swallowed and passed on to the next part of the gut.

    see the human teeth

    Digestion is the process that converts the ingested foods into a form that can be

    absorbed and transported.

    http://g/digestion%20for%20sf-usi/Fundamental%20digestive%202/PREGASTRIC%20DIGESTION/humanpage.htmlhttp://g/digestion%20for%20sf-usi/Fundamental%20digestive%202/PREGASTRIC%20DIGESTION/humanpage.html
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    Dental Formulae

    Deciduous2 1 0 2

    2 1 0 2= 10 Permanent

    2 1 2 3

    2 1 2 3= 16

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    SALIVA

    Saliva is produced in and secreted from salivary glands. The basic secretory units of salivary

    glands are clusters of cells called an acini.

    The three major pairs of salivary glands are:

    parotid glands produce a serous, watery secretion

    submaxillary (mandibular) glands produce a mixed serous and mucous secretion

    sublingual glands secrete a saliva that is predominantly mucous in character

    The basis for different glands secreting saliva of differing composition can be seen by examining

    salivary glands histologically. Two basic types of acinar epithelial cells exist:

    serous cells, which secrete a watery fluid, essentially devoid of mucus

    mucous cells, which produce a very mucus-rich secretion

    Saliva contains of mucus to lubricate the food and hydrogencabonate to provide the ideal condition

    of pH for amylase to work.

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    ESOPHAGUS

    The bolus can be ensured to travel down the esophagus by epiglottis.

    The bolus is swallowed and enters the esophagus and it will be pushed down towards the

    stomach by peristalsis (wave of esophagus muscular contraction).

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    STOMACH

    The stomach contains digestive glands that produce 3 important secretion :

    mucus protect the walls of the stomach from attack by gastric juices

    pepsinProteases: Pepsinogen, an inactive zymogen, is secreted into gastric juice from

    both mucous cells and chief cells. Once secreted, pepsinogen is activated by stomach acid

    into the active protease pepsin, which is largely responsible for the stomach's ability to initiate

    digestion of proteins. Chief cells also secrete chymosin (rennin), a protease that coagulates

    milk protein.

    hydrochloric acid provides the acidic conditions neede for the action of pepsin.

    Hormones: The principal hormone secreted from the gastric epithelium is gastrin, a peptide

    that is important in control of acid secretion and gastric motility

    Inside the stomach the food is chuened up with the gastric juices into a creamy liquid called

    chyme.

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    SMALL INTESTINE

    The digestion of molecules is completed in the small intestine, using digestive juices that

    contain:

    enzymes from the pancreas amylase, protease, and lipase (see table 2)

    enzymes from the intestine wall maltase, sucrase (see table 2)

    bile from the liver.

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    LARGE INTESTINE

    Some of food d that enter the small intetine cant be digested and absorbed into the

    bloodstream.

    These foods are :

    indigestible fiber

    undigested food some digestible food that may not be completely digested in

    the small intestine

    Those foods make up the bodys solid and pass into the large intestine.

    In the large intestine wateris absorbed

    waste materials form fecal material (faeces)

    See Gastrointestinal Transit: How Long Does It Take?

    http://g/digestion%20for%20sf-usi/Fundamental%20digestive%202/THE%20STOMACH/transit.htmlhttp://g/digestion%20for%20sf-usi/Fundamental%20digestive%202/THE%20STOMACH/transit.html
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    THE DIGESTIVE ENZYMES

    Site

    Mouth

    Stomach

    Small intestine

    (from pancreas)

    Small intestine

    Enzyme Role in Digestion

    Salivary amylase

    Pepsin

    Amylase

    Trypsin

    Lipase

    Maltase, sucrase, lactase

    Peptidase

    Breaks down starches into

    disaccharides

    Breaks down proteins into large

    peptidesContinues the breakdown of

    starch

    Continues the breakdown of

    protein

    Breaks down fat

    Breaks down remainingdisaccharides into

    monosaccharides

    Breaks down dipeptides into

    amino acids.

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    LIVER & PANCREAS

    Liver

    Gallbladder

    Duodenum

    Bile duct

    Pancreas

    Pancreatic duct

    To rest of small intestineCholecystokinin is the principle stimulus for delivery of pancreaticenzymes and bile into the small intestine.

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    SMALL INTESTINE

    Small Intestine Villus

    Circular folds

    Epithelial cells

    Capillaries

    Lacteal

    Vein

    Artery

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    EXERCISE

    1. What happens to solids that are indigestible - for example, a rock or a penny? Will it remain

    forever in the stomach?"

    If the indigestible solids are large enough, they indeed cannot pass into the small intestine, and

    will either remain in the stomach for long periods, induce a gastric obstruction or, as every catowner knows, be evacuated by vomition However, many of the indigestible solids that fail to pass

    through the pylorus shortly after a meal do pass into the small intestine during periods between

    meals.