diseases of oral cavity final
TRANSCRIPT
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Diseases of oral cavity
Dr.Ramanujam.S M.S.,
Assistant professor,
General surgery.
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CONTENTS
• ORAL CAVITY ANATOMY
• EXAMINATION OF ORAL CAVITY
• ORAL PATHOLOGY
• ORAL MANIFESTATION OF SYSTEMIC DISEASES
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ORAL PATHOLOGY
– MUCOUSAL LESIONS– ULCERATIVE LESIONS– MALIGNANCY– DISEASES OF TEETH AND PULP,
GINGIVA– DISEASES OF BONES (MANDIBLE AND
MAXILLA)
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Background
The mouth (buccal cavity) is the reservoir for the chewing and mixing of food with saliva.
It is the primary site of digestion and respiration as well as the primary communication structure.
It is the first part of the digestive tract and is exposed to various exogenous stimuli and exposure of longer duration can lead to reactive changes that need to be differentiated from malignancies
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Anatomy of oral cavityAnatomy of oral cavity
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Anatomy of oral cavityAnatomy of oral cavity
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Examination of Examination of the Oral Cavitythe Oral Cavity
Physical EvaluationPhysical Evaluation
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Oral ExaminationOral Examination
Many diseases (systemic or local) Many diseases (systemic or local) have signs that appear on the have signs that appear on the face, head & neck or intra-orallyface, head & neck or intra-orally
Making a complete examination Making a complete examination can help you create a differential can help you create a differential diagnosis in cases of diagnosis in cases of abnormalities and make abnormalities and make treatment recommendations treatment recommendations based on accurate assessment of based on accurate assessment of the signs & symptoms of diseasethe signs & symptoms of disease
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Oral ExaminationOral Examination
Each disease process may have Each disease process may have individual manifestations in an individual manifestations in an individual patientindividual patient
And there may be individual host And there may be individual host reaction to the diseasereaction to the disease
Careful assessment will guide the Careful assessment will guide the clinician to accurate diagnosisclinician to accurate diagnosis
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Scope of responsibilityScope of responsibility
Diseases of the head & neckDiseases of the head & neck Diseases of the supporting hard Diseases of the supporting hard
& soft tissues& soft tissues Diseases of the lips, tongue, Diseases of the lips, tongue,
salivary glands, oral mucosasalivary glands, oral mucosa Diseases of the oral tissues which Diseases of the oral tissues which
are a component of systemic are a component of systemic diseasedisease
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EquipmentEquipment
Assure that you have all the supplies Assure that you have all the supplies necessary to complete an oral necessary to complete an oral examinationexamination MirrorMirror Tissue retractor (tongue blade)Tissue retractor (tongue blade) Dry gauzeDry gauze
You must dry some of the tissues in You must dry some of the tissues in order to observe the nuances of any order to observe the nuances of any color changescolor changes
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Exam of the Head & Neck; Exam of the Head & Neck; Oral CavityOral Cavity Be systematicBe systematic Consistently complete the exam Consistently complete the exam
in the same orderin the same order
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Extra-oral examinationExtra-oral examination
Observe: color of skinObserve: color of skin Examination area of head & neckExamination area of head & neck
Determine: gross functioning of Determine: gross functioning of cranial nervescranial nerves Normal vs. abnormal Normal vs. abnormal
ParalysisParalysis Stroke, trauma, Bell’s PalsyStroke, trauma, Bell’s Palsy
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Extra-oral examinationExtra-oral examination
TMJTMJ Palpate upon openingPalpate upon opening
What is the maximum intermaxillary What is the maximum intermaxillary space?space?
Is the opening symmetrical?Is the opening symmetrical? Is there popping, clicking, grinding?Is there popping, clicking, grinding?
What do these sounds tell you about the What do these sounds tell you about the anatomy of the joint?anatomy of the joint?
When do sounds occur?When do sounds occur? Use your stethoscope to listen to soundsUse your stethoscope to listen to sounds
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Extra-oral examinationExtra-oral examination
Lymph node Lymph node palpationpalpation Refer to handoutRefer to handout
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Thyroid Gland EvaluationThyroid Gland Evaluation
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Extra-oral examinationExtra-oral examination
Thyroid Gland Thyroid Gland PalpationPalpation Place hands over Place hands over
the tracheathe trachea Have the patient Have the patient
swallowswallow The thyroid gland The thyroid gland
moves upwardmoves upward
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Exam: LipsExam: Lips
Observe the color & its Observe the color & its consistency-intra-orally and consistency-intra-orally and externallyexternally
Is the vermillion border distinct?Is the vermillion border distinct? Bi-digitally palpate the tissue Bi-digitally palpate the tissue
around the lips. Check for around the lips. Check for nodules, bullae, abnormalities, nodules, bullae, abnormalities, mucocele, fibromamucocele, fibroma
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Exam: LipsExam: Lips
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Exam: LipsExam: Lips
Evert the lip and examine the tissueEvert the lip and examine the tissue Observe frenulum Observe frenulum
attachment/tissue tensionattachment/tissue tension Clear mucous filled pockets may be Clear mucous filled pockets may be
seen on the inner side of the lip seen on the inner side of the lip (mucocele). This is a frequent, (mucocele). This is a frequent, non-pathologic entity which non-pathologic entity which represents a blocked minor salivary represents a blocked minor salivary glandgland
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Exam: Lips-palpationExam: Lips-palpation
Color, consistencyColor, consistency Area for blocked minor salivary Area for blocked minor salivary
glandsglands Lesions, ulcersLesions, ulcers
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Exam: LipsExam: Lips
Frenum:Frenum: AttachmentAttachment Level of attached Level of attached
gingivagingiva
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Exam: Lips-sun exposureExam: Lips-sun exposure
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Exam: LipsExam: Lips
Palpate in the Palpate in the vestibule, vestibule, observe colorobserve color
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Examination: Buccal Examination: Buccal MucosaMucosa Observe color, character of the mucosaObserve color, character of the mucosa
Normal variations in color among ethnic Normal variations in color among ethnic groupsgroups
Amalgam tattoo Amalgam tattoo Palpate tissuePalpate tissue Observe Stenson’s duct opening for Observe Stenson’s duct opening for
inflammation or signs of blockageinflammation or signs of blockage Visualize muscle attachments, hamular Visualize muscle attachments, hamular
notch, pterygomandibular foldsnotch, pterygomandibular folds
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Examination: Buccal Examination: Buccal MucosaMucosa Linea albaLinea alba Stenson’s ductStenson’s duct
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Examination: Buccal Examination: Buccal MucosaMucosa Lesions – white, red Lesions – white, red Lichen Planus, Leukedema Lichen Planus, Leukedema
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GingivaGingiva
Note color, tone, Note color, tone, texture, texture, architecture & architecture & mucogingival mucogingival relationshipsrelationships
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GingivaGingiva
How would you describe the gingiva?How would you describe the gingiva? Marginal vs. generalized?Marginal vs. generalized? Erythematous vs. fibrousErythematous vs. fibrous
Drug reactions: Anti-epileptic, Drug reactions: Anti-epileptic, calcium channel blockers, calcium channel blockers, immunosuppressant immunosuppressant
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Exam: Hard palateExam: Hard palate
Minor salivary glands, attached Minor salivary glands, attached gingivagingiva
Note presence of tori: tx plan Note presence of tori: tx plan any pre-prosthetic surgery any pre-prosthetic surgery
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Exam: Soft palateExam: Soft palate
How does soft palate raise upon How does soft palate raise upon “aah”?“aah”?
Vibrating line, tonsilar pillars, Vibrating line, tonsilar pillars, tonsils, oropharynxtonsils, oropharynx
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Exam: OropharanyxExam: Oropharanyx
Color, consistency of tissueColor, consistency of tissue Look to the back, beyond the soft Look to the back, beyond the soft
palatepalate Note occasional small globlets of Note occasional small globlets of
transparent or pink opaque transparent or pink opaque tissue which are normal and may tissue which are normal and may include lymphoid tissueinclude lymphoid tissue
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Exam: TonsilsExam: Tonsils
Tucked in at base of anterior & Tucked in at base of anterior & posterior tonsilar pillarsposterior tonsilar pillars
Globular tissue that has Globular tissue that has “punched out” appearing areas“punched out” appearing areas
Regresses after adulthoodRegresses after adulthood May see white “orzo rice like” or May see white “orzo rice like” or
“torpedo” shaped white “torpedo” shaped white concretions within the tissueconcretions within the tissue
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Exam: TongueExam: Tongue
The tongue and the floor of the The tongue and the floor of the mouth are the most common mouth are the most common places for oral cancer to occurplaces for oral cancer to occur
It can occur other places; so It can occur other places; so visualize all areasvisualize all areas
You may observe:You may observe: Circumvalate papillae, epiglottisCircumvalate papillae, epiglottis
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Exam: TongueExam: Tongue
Have the patient stick out their Have the patient stick out their tonguetongue
Wrap the tongue in a dry gauze Wrap the tongue in a dry gauze and gently pull it from side to and gently pull it from side to side to observe the lateral side to observe the lateral bordersborders
Retract the tongue to view the Retract the tongue to view the inferior tissuesinferior tissues
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Exam: TongueExam: Tongue
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Exam: TongueExam: Tongue
You may observe You may observe lingual lingual varicosities varicosities
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Exam: TongueExam: Tongue
You may observe geographic You may observe geographic tongue (erythema migrans)tongue (erythema migrans)
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Exam: TongueExam: Tongue
You may observe drug reactionYou may observe drug reaction
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Exam: TongueExam: Tongue
Observe signs of nutritional Observe signs of nutritional deficiencies, immune dysfunctiondeficiencies, immune dysfunction
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Exam: TongueExam: Tongue
You may observe You may observe oral canceroral cancer
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Exam: Floor of mouthExam: Floor of mouth
Visualize, palpate - bimanuallyVisualize, palpate - bimanually Wharton’s duct Wharton’s duct Must dry to observeMust dry to observe
Does “lesion” wipe off?Does “lesion” wipe off? Where are the two mostWhere are the two most
likely areas for oral cancer?likely areas for oral cancer? lateral border of the tonguelateral border of the tongue Floor of mouthFloor of mouth
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Palpation of the floor of the Palpation of the floor of the mouthmouth
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Exam: Floor of mouthExam: Floor of mouth
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Exam: Floor of mouthExam: Floor of mouth
Squamous Cell CarcinomaSquamous Cell Carcinoma
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Exam: Floor of mouthExam: Floor of mouth
Squamous Cell CarcinomaSquamous Cell Carcinoma
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Exam: Leukoplakic area Exam: Leukoplakic area
Edentulous Mandibular Ridge
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Exam: Floor of mouthExam: Floor of mouth
Oral Cancer:Oral Cancer: RedRed WhiteWhite Red and WhiteRed and White
Does the patient have important Does the patient have important risk factors for oral cancer?risk factors for oral cancer? Counseling for smoking and alcoholCounseling for smoking and alcohol
Cessation Cessation
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Squamous Cell Squamous Cell CarcinomaCarcinoma
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Triaging Lesions Triaging Lesions **
Describe it’s characteristicsDescribe it’s characteristics Size, shape, color, consistency, locationSize, shape, color, consistency, location
How long has it been present?How long has it been present? Is it related to a trauma?Is it related to a trauma?
Fractured cusp, occlusal traumaFractured cusp, occlusal trauma Has it occurred before?Has it occurred before? Can you wipe it off? Can you wipe it off? Does the patient have specific risk Does the patient have specific risk
factors for neoplastic lesions?factors for neoplastic lesions?
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Triaging Lesions Triaging Lesions **
Any lesion that is suspicious Any lesion that is suspicious should be re-evaluated in 2 should be re-evaluated in 2 weeksweeks Lesions due to infectious processes Lesions due to infectious processes
would have healed in that time would have healed in that time frameframe
If it remains, the lesions should be If it remains, the lesions should be biopsiedbiopsied
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Exam: Maxilla & Exam: Maxilla & MandibleMandible• size, shape, contour
• pre-prosthetic treatment
•Tori removal
• tuberosity reduction
•Soft or hard tissue or both
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Exam: Maxilla & Exam: Maxilla & MandibleMandible
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Exam: Maxilla & Exam: Maxilla & MandibleMandible
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Exam: Maxilla & Exam: Maxilla & MandibleMandible Evaluate for Evaluate for
Epulis fissuratumEpulis fissuratum
If you make a If you make a new denture will new denture will the excess tissue the excess tissue resolve?resolve?
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OcclusionOcclusion
Orthodontic Orthodontic classificationclassification
InterferencesInterferences
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OcclusionOcclusion
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Systematic Oral Systematic Oral ExaminationExamination Done at initial exam & at recalls Done at initial exam & at recalls
unless patient history requires soonerunless patient history requires sooner You must visualize all areas of the You must visualize all areas of the
oral cavityoral cavity Oral cancer can occur in other places Oral cancer can occur in other places
than the lateral borders of the tongue than the lateral borders of the tongue & the floor of the mouth& the floor of the mouth
Be completeBe complete Do good, do no harm, do justice, Do good, do no harm, do justice,
respect autonomyrespect autonomy
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Visualize all areasVisualize all areas
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BreathBreath
Oral odors can indicate:Oral odors can indicate: Infection: caries, periodontal dxInfection: caries, periodontal dx URT infectionsURT infections Chronic G.I. disturbancesChronic G.I. disturbances Lung abscessLung abscess Diabetic acidosisDiabetic acidosis Uremia, kidney problemUremia, kidney problem Liver failure: mousy, musty odorLiver failure: mousy, musty odor Self-medication with alcoholSelf-medication with alcohol
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Example of Dental Example of Dental ChartingCharting
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ORAL PATHOLOGYORAL PATHOLOGY
DEFINITION—THE STUDY OF DISEASES IN THE ORAL CAVITY.
MANY SYSTEMIC AS WELL AS INFECTIOUS DISEASES HAVE ORAL MANIFESTATIONS.
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If mucosal lesions are evident:If mucosal lesions are evident:
• Try to remove local factors that could have contributed to the lesion
• commence anti-inflammatory treatment for two weeks, if lesion remains: biopsy
• a diagnosis based on clinical appearance alone is usually not sufficient to determine the histological nature of the tissue
• Try to remove local factors that could have contributed to the lesion
• commence anti-inflammatory treatment for two weeks, if lesion remains: biopsy
• a diagnosis based on clinical appearance alone is usually not sufficient to determine the histological nature of the tissue
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Oral LesionsOral Lesions
By colour change• White lesions• Red lesions• Red and white
lesions• pigmented lesions
By colour change• White lesions• Red lesions• Red and white
lesions• pigmented lesions
By surface change• nodules• vesiculobullous
lesions• ulcerative lesions
By surface change• nodules• vesiculobullous
lesions• ulcerative lesions
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Oral lesionsOral lesions
White lesions:• Leukoplakia• Lichen• Leukoedema• Morsicatio
buccarum• White Sponge
Neavus• Fordyce’s Granules
White lesions:• Leukoplakia• Lichen• Leukoedema• Morsicatio
buccarum• White Sponge
Neavus• Fordyce’s Granules
Red lesions:• Erythroplakia• Varicosity• Hemangioma• Purpura (Petechiae,
Ecchymosis)• Sturge-Weber
Angiomatosis• Hereditary
Hemorrhagic Teleangiectasia
Red lesions:• Erythroplakia• Varicosity• Hemangioma• Purpura (Petechiae,
Ecchymosis)• Sturge-Weber
Angiomatosis• Hereditary
Hemorrhagic Teleangiectasia
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Oral lesionsOral lesions
Red-white lesions
• speckled Erythroplakia
• Squamous Cell Carcinoma
• Lichen planus
• Lupus Erythematodes
• Lichenoid Drug Reactions
• Candidiasis (Candidal Leukoplakia, Anti-biotic Sore Mouth, Denture Stomatitis)
Red-white lesions
• speckled Erythroplakia
• Squamous Cell Carcinoma
• Lichen planus
• Lupus Erythematodes
• Lichenoid Drug Reactions
• Candidiasis (Candidal Leukoplakia, Anti-biotic Sore Mouth, Denture Stomatitis)
Pigmented lesions• Melanoplakia• Tobacco associated
Pigmentation (Smokers Melanosis)
• Nevus• Malignant Melanoma• Peutz-Jeghers
Syndrome• Addisons’s Disease• Amalgam Tattoo
Pigmented lesions• Melanoplakia• Tobacco associated
Pigmentation (Smokers Melanosis)
• Nevus• Malignant Melanoma• Peutz-Jeghers
Syndrome• Addisons’s Disease• Amalgam Tattoo
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Background Definitions
Gingivitis-inflammation of the gumsXerostomia-abnormal dryness of the mouth due
to insufficient secretions Mucositis-inflammation of a mucous membrane Stomatitis-inflammation of the mouth having
various causes (as mechanical trauma, allergy, vitamin deficiency, or infection)
Cheilitis-inflammation of the lipGlossitis-inflammation of the tongue
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LeukoplakiaLeukoplakia
White lesions on the mucosa which will not rub of and can not be classified as any other
disease (WHO 1978)
• is a clinical descriptive term, not a histological diagnosis
White lesions on the mucosa which will not rub of and can not be classified as any other
disease (WHO 1978)
• is a clinical descriptive term, not a histological diagnosis
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Leukoplakia
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EtiologyEtiology
• Combination of extrinsic local factors and intrinsic predisposing factors
• Initiation through chemical or mechanical irritation: – chemical: alcohol, tobacco– mechanical: sharp tooth or crown
margins, irritating denture clasps
• Combination of extrinsic local factors and intrinsic predisposing factors
• Initiation through chemical or mechanical irritation: – chemical: alcohol, tobacco– mechanical: sharp tooth or crown
margins, irritating denture clasps
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Histologic FeaturesHistologic Features
• Leukoplakia usually shows hyperkeratosis or acanthosis with or without dysplasia (20% show dysplasia)
• white colour change is the sign of hyperkeratosis
• Leukoplakia usually shows hyperkeratosis or acanthosis with or without dysplasia (20% show dysplasia)
• white colour change is the sign of hyperkeratosis
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Clinical appearance - homogeneous and non-
homogeneous Leukoplakia
Clinical appearance - homogeneous and non-
homogeneous Leukoplakia
• Homogeneous: non-palpable, faintly translucent white discoloration
• non-homogeneous: – verrucous or nodular– speckled: hyperkeratotic white areas
and red areas– errosive: fissuring and ulcer formation
• Homogeneous: non-palpable, faintly translucent white discoloration
• non-homogeneous: – verrucous or nodular– speckled: hyperkeratotic white areas
and red areas– errosive: fissuring and ulcer formation
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Site of Leukoplakia
• Risk of dysplasia/carcinoma higher with floor of mouth, ventrolateral tongue, retromolar trigone, soft palate than with other oral sites
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• Clinical shift in appearance from homogenous to heterogenous, speckled, or nodular, a rebiopsy is mandatory
• Correlation between increasing levels of dysplasia and increases in regional heterogeneity or speckled quality
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Sites of predilectionSites of predilection
• Lateral and ventral tongue
• floor of the mouth
• alveolar ridge mucosa
• corner of the mouth
• less frequently:– soft palate – lip
• Lateral and ventral tongue
• floor of the mouth
• alveolar ridge mucosa
• corner of the mouth
• less frequently:– soft palate – lip
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High risk sitesHigh risk sites
• 4-6% of leukoplakias progress to squamous cell carcinoma within 5 years
• high risk sites of malignancy:– floor of the mouth– lateral and ventral tongue– lips
• 4-6% of leukoplakias progress to squamous cell carcinoma within 5 years
• high risk sites of malignancy:– floor of the mouth– lateral and ventral tongue– lips
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Differential diagnosisDifferential diagnosis
Nicotine Stomatitis
Candidiasis
Hairy Leukoplakia
Leukoedema
White sponge naevus
Fordyce granules
Nicotine Stomatitis
Candidiasis
Hairy Leukoplakia
Leukoedema
White sponge naevus
Fordyce granules
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Treatment
• Trial of cessation of offending agent, follow-up• Guided by microscopic characterization• Benign, minimally dysplastic- periodic
observation or elective excision• Complete excision can be performed with
scalpel excision, laser ablation, electrocautery, or cryoablation
• Chemoprevention
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Erosions and ulceration are a clinical sign of malignant
transformation
Erosions and ulceration are a clinical sign of malignant
transformation
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DysplasiaDysplasia
• mild: affects only basal 1/3 of epithelium
• moderate: affects half of epithelial layer
• severe: more than 2/3 of epithelium affected
• Carcinoma in situ (CIS): the whole thickness of epithelium is involved but the basement membrane is intact
• mild: affects only basal 1/3 of epithelium
• moderate: affects half of epithelial layer
• severe: more than 2/3 of epithelium affected
• Carcinoma in situ (CIS): the whole thickness of epithelium is involved but the basement membrane is intact
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Treatment
• Trial of cessation of offending agent, follow-up• Guided by microscopic characterization• Benign, minimally dysplastic- periodic
observation or elective excision• Complete excision can be performed with
scalpel excision, laser ablation, electrocautery, or cryoablation
• Chemoprevention
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Hairy leukoplakiaHairy leukoplakia
• Oral sign of HIV infection
• viral origin likely (Epstein-Barr virus)
• frequently associated with Candida albicans
• Oral sign of HIV infection
• viral origin likely (Epstein-Barr virus)
• frequently associated with Candida albicans
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Lichen planusLichen planus
• Common skin disease with oral manifestation (ca 30% of cases) or oral lesions without cutaneous signs
• most likely immunologic disorder in which T lymphocytes destroy the basal cell layer of the affected epithelium
• Common skin disease with oral manifestation (ca 30% of cases) or oral lesions without cutaneous signs
• most likely immunologic disorder in which T lymphocytes destroy the basal cell layer of the affected epithelium
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Lichen planusLichen planus
• Frequently affected sites: – buccal mucosa– dorsal tongue
• less frequently affected:– lips– palate– gingiva– floor of mouth
• Frequently affected sites: – buccal mucosa– dorsal tongue
• less frequently affected:– lips– palate– gingiva– floor of mouth
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Lichen planusLichen planus
• Four appearances of oral lichen planus:– striated (reticular)– atrophic– erosive– plaquelike
• Four appearances of oral lichen planus:– striated (reticular)– atrophic– erosive– plaquelike
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ErythroplakiaErythroplakia
• Def: persistent red patch that cannot be characterized clinically as any other condition
• redness of the lesion is a result of atrophic mucosa overlying highly vascular submucosa
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Erythroplakia
Area of Squamous Cell Carcinoma Surrounded by Erythroplakia
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ErythroplakiaErythroplakia
• Most erythroplakia are histologically diagnosed epithelial dysplasia or worse
• much higher chance of progression to carcinoma
• biopsy is mandantory
• Most erythroplakia are histologically diagnosed epithelial dysplasia or worse
• much higher chance of progression to carcinoma
• biopsy is mandantory
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CONDITIONS OF THE TONGUE
• GLOSSITIS
– General term used to describe inflammation and changes to the tongue.
– FOUR MAIN TYPES
• BLACK HAIRY TONGUE• GEOGRAPHIC TONGUE• FISSURED TONGUE• PERNICIOUS ANEMIA
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BLACK HAIRY TONGUE
– caused by an oral flora imbalance after the administration of antibiotics– the filiform papillae become elongated so that they resemble hairs, they then become stained by food,
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• GEOGRAPHIC TONGUE
• the surface of the tongue loses areas of the filiform papillae in irregularly shaped patterns
• the smooth areas resemble a map.
• over days or weeks the smooth areas and the whitish margins seem to change locations across the surface of the tongue
• affects 1-3% of the population
• occurs at all ages
• women have it twice as much as males
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– FISSURED TONGUE
• considered a variation of normal
• etiology is unknown
• theories include a vitamin deficiency or chronic trauma over a long period
• dorsum of tongue appears to have deep fissures or grooves that become irritated if debris collects in them
• patient is advised to brush tongue with a soft toothbrush
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– PERNICIOUS ANEMIA• a condition in which the body does not absorb vitamin b 12• oral manifestation of pernicious anemia include angular cheilitis • ulceration and redness at the corners of the lips• loss of papillae of the tongue• a burning and painful tongue
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Ulcerative Lesion
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Things to Consider
Most Likely: Aphthous ulcer, HSV, Trauma, Malignancy
Less Likely: Varicella Zoster, Autoimmune disease, Fungal infection, Malnourishment
Must Rule Out: Malignancy, Immunosuppresion, Bacterial/Fungal disease, Some of the autoimmune diseases
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Differential Diagnosis• Infection
– HSV, Actinomycosis, CMV, Varicella Zoster, Coxsackievirus, Syphilis, Candidiasis, Cryptosporidium, Histoplasma (fungal typically seen in immunocompromised)
• Autoimmune
– Behçet's syndrome, Lupus, Crhon’s Disease, Pemphigoid, Lichen Planus, Aphthous ulceration, Erythema multiforme
• Neoplasm
• Trauma Induced (necrotizing sialometaplasia)
• Malnourishment: Vitamin B deficiencies, Vitamin C deficiency, Iron deficiency, Folic acid deficiency
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What to Do Next?
-Work from most common to least common, and rule out the things that will cause the most morbidity or mortality
1. Biopsy the lesion
2. Check labs (ensure not immunocomprimised) – finger stick glucose in office, CBC, CMP, A1c
3. Rule out infection: Send swab and biopsy for HSV testing (smear, PCR) as well as gram stain and possible culture (viral/bacterial)
Final Diagnosis: Major Aphthous Ulcer
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Aphthous Ulcers
• Most common cause of non-traumatic ulcerations of the oral cavity
• Etiology unclear• 10-20% of general population• Diagnosis of exclusion
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Aphthous Ulcers
• Classifications– Minor aphthous ulcer
» < 1cm in diameter» Located on freely mobile oral mucosa» Appears as a well-delineated white
lesion with an erythematous halo» Prodrome of burning or tingling in
area prior to ulcer’s appearance» Resolve in 7-10 days» Never scars
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Aphthous Ulcers– Major aphthous ulcer
» > 1cm in diameter» Involves freely mobile mucosa,
tongue, and palate» Last much longer – 6 weeks or
more» Typically scar upon healing
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Aphthous Ulcers
– Herpetiform ulcers» Small, 1-3mm in diameter ulcerations
appearing in crops of 20-200 ulcers» Typically located on mobile oral mucosa,
tongue, and palate» Last 1-2 weeks» Called herpetiform because ulcerations
resemble those of HSV, but there is no vesicular phase
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Aphthous Ulcers Cont.
– Treatment»Topical tetracycline solution for 5-7 days has
shown good results»Topical steroids shown to shorten disease
duration»Sucralfate suspension shown to improve pain
as well as shorten disease duration»Major aphthous ulcers or more severe forms of
disease require 2 week course of systemic steroids
• KEY TO DIAGNOSIS: Diagnosis of exclusion; clinical appearance/course
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– Any ulceration that fails to heal in 1-2 weeks should be biopsied
– Associated Premalignant lesions• Leukoplakia• Erythroplakia
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Oral Malignancy
– Malignancy• 30% of all head and neck cancer occur in the oral
cavity (most common site of head and neck cancer)• Symptoms/findings – non-healing ulcerations, pain,
expansile lesion, trismus, dysphagia, odonyphagia, halitosis, numbness in lower teeth (inferior alveolar nerve involvement)
• Indicators of more aggressive tumors – require more aggressive treatment– 4mm of invasion– > 1cm in size– Perineural, lymphatic, or vascular invasion
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Types of Oral Cancer– Squamous cell carcinoma – most common (90% of
cases)– Basal cell carcinoma – more common on upper lip– Verrucous carcinoma
» Variant of squamous cell carcinoma» Less aggressive (rare metastasis or deep invasion)» Most common site is on buccal mucosa» Warty lesion
– Salivary gland malignancy» Most common in oral cavity is adenoid cystic carcinoma» Mucoepidermoid carcinoma» Adenocarcinoma
– Lymphoma – both Hodgkin’s and non-Hodgkin’s types– Sarcomas – most commonly rhabdomyosarcoma and
liposarcoma; look for Kaposi’s sarcoma in AIDS patients– Melanoma
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Oral manifestation of systemic diseases.
• Drug Reactions• Fungal infections• Viral infections• Leukemia• Behcet’s Disease• Diabetes Mellitus• Nutritional Deficiencies• Amyloidosis
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Behcet’s Disease
• Behcet’s disease is a rare disorder mainly affecting young men.
• While the disease affects multiple organ systems, oral ulcerations resembling canker sores present in 99% of patients.
• The oral lesions are the herald of this disease and are usually 6mm or smaller and resolve within 1-3 weeks.
• Treatment is symptomatic and supportive. Medication may be prescribed to reduce inflammation and/or regulate the immune system. Immunosuppressive therapy may be considered.
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Behcet’s Disease
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Sjögren’s Syndrome• Sjögren’s syndrome is the 2nd most common
autoimmune disease with women in their mid-60’s being the primarily afflicted.
• Initial symptoms include dry eyes and dry mouth due to gradual glandular dysfunction.
• In some cases, dysphagia, increased dental caries, increased susceptibility to oral candidiasis, and difficulty wearing dental prostheses will develop.
• Treatment is generally symptomatic and supportive. Moisture replacement therapies may ease the symptoms of dryness. Nonsteroidal anti-inflammatory drugs may be used to treat musculoskeletal symptoms. Corticosteroids or immunosuppressive drugs may be considered in severe cases.
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Sjögren’s Syndrome
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Drug Reactions- SJS and TEN• Stevens-Johnson syndrome and toxic epidermal
necrolysis are rare, life-threatening, drug induced reactions.
• 7 to 21 days after exposure purpuric and erythematous macules evolve to skin necrosis and epidermal detachment.
• Oral mucous membrane involvement occurs in up to 50% of cases and may impair ingestion of nutrition.
• Most commonly implicated in these reactions are sulfonamides, penicillins, phenytoin, and phylbutazone.
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Erythema Multiforme
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Carry home messages
• Thorough examination is vital in diagnosis and management of diseases of oral cavity.
• Any suspicious lesion should be biopsied.
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