division of neurosurgery institute of neurology · 2019-12-04 · ul neurosurgery annual report...

DIVISION OF NEUROSURGERY

INSTITUTE OF NEUROLOGY

2016 ANNUAL REPORT

UCL NEUROSURGERY ANNUAL REPORT 2016

1

Contents

Division Head’s Report __________________________________________________________________________________ 2

Clinical Activity ___________________________________________________________________________________________ 3

Grants _____________________________________________________________________________________________________ 6

Awards ____________________________________________________________________________________________________ 7

Publications ______________________________________________________________________________________________ 8

Presentations ____________________________________________________________________________________________ 14

Organisation of Courses and Symposia _______________________________________________________________ 20

Public Engagement Activities & Scientific Advisory Boards _________________________________________ 22

Contact Information ____________________________________________________________________________________ 23

Department Information _______________________________________________________________________________ 23


2

Division Head’s Report

This Annual Report follows my first full calendar year at UCL. The intent of this report is to briefly outline

divisional activity in 2016.

In late 2015, the Institute of Neurology Division of Neurosurgery commissioned an external review of the

division in order to provide guidance for the future development of academic neurosurgery at the Institute

of Neurology. The review was chaired by John Pickard, Professor (Emeritus), University of Cambridge, and

included Professors Mike Tymianski (University of Toronto) and Tom Jessell (Columbia University). Over

the course of two days, the committee interviewed a number of people. Their extensive final report was

received in April 2016, and the Division has been working towards implementing their recommendations.

In addition to academic productivity, which is the focus of this report, I have included some measures of

neurosurgical clinical activity in the Victor Horsley Department of Neurosurgery at Queen Square, as our

patients form the foundation of academic progress. I note that UCL and NHS neurosurgeons function as a

group, with the common goal of improving the lives of people – today and tomorrow – who suffer from

diseases of and injuries to their nervous systems. This relationship is also reflected in the academic activity

reported in these pages, which includes that of UCL neurosurgeons as well as that of NHS neurosurgeons,

many of whom hold honorary UCL appointments.

In June 2016, the Division held an “Open for Research” day. About 100 people from across UCL attended to

learn about treatments of patients in each of the neurosurgical subspecialty areas, with a key goal being to

enhance research collaborations across the campus. The feedback was excellent, and new relationships

were formed that I am confident will lead to new translational research projects.

In November 2016, the Institute of Neurology held a symposium to mark the 100th centenary of the death

of Sir Victor Horsley. The Division was honoured to host Dr Zelma Kiss from the University of Calgary,

whose thoughtful and well-received 2016 Sir Victor Horsley Lecture was entitled “History of stereotactic

and functional neurosurgery: A marriage of science and surgery.”

I look forward to further growth in the Division’s academic productivity in the coming years as we welcome

a new era of academic neurosurgery at Queen Square.

Rob Brownstone

June 2017


3

Clinical Activity

At Queen Square, we provide clinical neurosurgical service for most subspecialty areas of neurosurgery,

with the exceptions of trauma and paediatrics. Despite the lack of these cases, which normally comprise a

large proportion of neurosurgical activity, we had the second highest number of neurosurgical admissions

in the country, with close to 4,000 admissions per year.

NUMBER OF ADMISSIONS (APRIL 2013-2016)


4

Included below are some examples of super-specialty clinical care.

Queen Square is a national referral centre for adult complex hydrocephalus. Our hydrocephalus team has

placed more shunts than any other centre in the country – about 120 per year.

SHUNT INSERTIONS (APRIL 2013-2016)


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Queen Square is also the leading centre for deep brain stimulation. The graph below shows the number of

new DBS insertions / implants per site from April 2013 through 2016. The number of DBS cases has been

increasing annually, with 80 new patients receiving treatment in the one year from April 2015-2016.

NUMBERS OF DEEP BRAIN STIMULATION PROCEDURES (APRIL 2013-2016)


6

Grants

PRINCIPLE INVESTIGATORS

1. David Choi: UCLH CRDC Fast track award F198. Optimising the culture of human olfactory ensheathing cells from olfactory mucosal biopsies, cell production and application to nerve repair. £43,952 (2016)

2. David Choi: Wellcome Health Innovation Challenge Fund. Characterisation of human olfactory

ensheathing cells in cultures of human olfactory mucosa, for the purpose of nerve regeneration.

£1,160,000 (2016-2019)

3. Robert Brownstone: Wellcome Trust Investigator Award. Tuning spinal motoneurons for

movement. £2,512,185 + IRS £950,000. (2016-2021)

4. Ludvic Zrinzo: Brain Research Trust Grant Award. Advanced Neuroimaging in patients

undergoing DBS £250,000 (2013-16)

5. Ludvic Zrinzo: Royal College of Surgeons of England. Neurofeedback in patients undergoing DBS

surgery. £150,000 (2014-2017)

CO-INVESTIGATORS

1. Andrew McEvoy, Rob Brownstone: Wellcome EPSRC Centre for Surgical and Interventional

Sciences, co-investigators (PI: S. Ourselin), £13,130,284 (2017-2022)

2. Andrew McEvoy, Anna Miserocchi: UCLH BRC Computational Imaging Infrastructure, co-

investigators (PI: S. Ourselin) £738,309 (2013-2018)

3. Andrew McEvoy, Anna Miserocchi: Wellcome Trust Programme Grant. “Image-guided

neurosurgical treatment of epilepsy,” co-investigators (PI: J. Duncan) £2,327,559 (2015-2019)

4. Marwan Hariz, Ludvic Zrinzo: MRC Grant - Experimental Medicine for Mental Health - “Deep

brain stimulation for severe obsessive compulsive disorder: Efficacy and mechanisms of ventral

striatum and subthalamic nucleus targets,” co-investigators (PI: E. Joyce) £302,000 (2013-16)


7

Awards

1. David Choi: Celebrating Clinical Excellence award, Finalist for “Living the values” patient

nominated award, given to one doctor in UCLH, Feb 2016.

2. Ludvic Zrinzo: Tony Pullen Lecturer of the Year Award, July 2016


8

Publications

PEER REVIEWED PAPERS

Ahmed M, Machado PM, Miller A, Spicer C, Herbelin L, He J, Noel J, Wang Y, McVey AL, Pasnoor M, Gallagher P,

Statland J, Lu CH, Kalmar B, Brady S, Sethi H, Samandouras G, Parton M, Holton JL, Weston A, Collinson L,

Taylor JP, Schiavo G, Hanna MG, Barohn RJ, Dimachkie MM, Greensmith L. Targeting protein homeostasis in

sporadic inclusion body myositis. Sci Transl Med. 2016 Mar 23;8(331):331ra41. doi:

10.1126/scitranslmed.aad4583.

Akram H, Miller S, Lagrata S, Hyam J, Jahanshahi M, Hariz M, Matharu M, Zrinzo L. Ventral tegmental area

deep brain stimulation for refractory chronic cluster headache. Neurology. 2016 May 3;86(18):1676-82.

doi: 10.1212/WNL.0000000000002632.

Andrews PJ, Poirrier AL, Lund VJ, Choi D. Safety of human olfactory mucosal biopsy for the purpose of

olfactory ensheathing cell harvest and nerve repair: a prospective controlled study in patients undergoing

endoscopic sinus surgery. Rhinology. 2016 Jun;54(2):183-91. doi: 10.4193/Rhin15.365.

Andrews PJ, Poirrier AL, Lund VJ, Choi D. Outcomes in endoscopic sinus surgery: olfaction, nose scale and

quality of life in a prospective cohort study. Clin Otolaryngol. 2016 Dec;41(6):798-803. doi:

10.1111/coa.12665.

Aristovich KY, Packham BC, Koo H, dos Santos GS, McEvoy A, Holder DS. Imaging fast electrical activity in the

brain with electrical impedance tomography. Neuroimage. 2016 Jan 1;124(Pt A):204-13. doi:

10.1016/j.neuroimage.2015.08.071.

Bartlett RD, Choi D, Phillips JB. Biomechanical properties of the spinal cord: implications for tissue

engineering and clinical translation. Regen Med. 2016 Oct;11(7):659-73. doi: 10.2217/rme-2016-0065.

Blomstedt P, Taira T, Hariz M. Rescue pallidotomy for dystonia through implanted deep brain stimulation

electrode. Surg Neurol Int. 2016 Nov 14;7(Suppl 35):S815-S817.

Borg A, Kirkman MA, Choi D. Endoscopic Endonasal Anterior Skull Base Surgery: A Systematic Review of

Complications During the Past 65 Years. World Neurosurg. 2016 Nov;95:383-391. doi:

10.1016/j.wneu.2015.12.105.

Bui TV, Stifani N, Akay T, Brownstone RM. Spinal microcircuits comprising dI3 interneurons are necessary

for motor functional recovery following spinal cord transection. Elife. 2016 Dec 15;5. pii: e21715. doi:

10.7554/eLife.21715.

Champeaux C, Wilson E, Shieff C, Khan AA, Thorne L. WHO grade II meningioma: a retrospective study for

outcome and prognostic factor assessment. J Neurooncol. 2016 Sep;129(2):337-45. doi: 10.1007/s11060-

016-2181-2.


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Chaudhary UJ, Centeno M, Thornton RC, Rodionov R, Vulliemoz S, McEvoy AW, Diehl B, Walker MC, Duncan JS,

Carmichael DW, Lemieux L. Mapping human preictal and ictal haemodynamic networks using simultaneous

intracranial EEG-fMRI. Neuroimage Clin. 2016 Mar 23;11:486-93. doi: 10.1016/j.nicl.2016.03.010.

Craven C, Asif H, Farrukh A, Somavilla F, Toma AK, Watkins L. Case series of ventriculopleural shunts in

adults: a single-center experience. J Neurosurg. 2017 Jun;126(6):2010-2016. doi:

10.3171/2016.4.JNS16641.

Craven C, Toma AK, Khan AA, Watkins LD. The role of ICP monitoring in patients with persistent

cerebrospinal fluid leak following spinal surgery: a case series. Acta Neurochir (Wien). 2016

Sep;158(9):1813-9. doi: 10.1007/s00701-016-2882-5.

Craven CL, Toma AK, Mostafa T, Patel N, Watkins LD. The predictive value of DESH for shunt responsiveness

in idiopathic normal pressure hydrocephalus. J Clin Neurosci. 2016 Dec;34:294-298. doi:

10.1016/j.jocn.2016.09.004.

Craven CL, Toma AK, Watkins LD. Persistent hydrocephalus due to postural activation of a ventricular shunt

anti-gravity device. J Clin Neurosci. 2017 Mar;37:91-95. doi: 10.1016/j.jocn.2016.11.004.

Deeb W, Rossi PJ, Porta M, Visser-Vandewalle V, Servello D, Silburn P, Coyne T, Leckman JF, Foltynie T, Hariz M,

Joyce EM, Zrinzo L, Kefalopoulou Z, Welter ML, Karachi C, Mallet L, Houeto JL, Shahed-Jimenez J, Meng FG,

Klassen BT, Mogilner AY, Pourfar MH, Kuhn J, Ackermans L, Kaido T, Temel Y, Gross RE, Walker HC, Lozano

AM, Khandhar SM, Walter BL, Walter E, Mari Z, Changizi BK, Moro E, Baldermann JC, Huys D, Zauber SE,

Schrock LE, Zhang JG, Hu W, Foote KD, Rizer K, Mink JW, Woods DW, Gunduz A, Okun MS. The International

Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work? Front

Neurosci. 2016 Apr 25;10:170. doi: 10.3389/fnins.2016.00170.

Georgiev D, Mehta D, Zacharia A, Vinke RS, Milabo C, Candelario J, Tripoliti E, Hyam JA, Zrinzo L, Hariz M,

O'Riordan S, Foltynie T and Limousin P. (2016), Bilateral Deep Brain Stimulation of the Globus Pallidus Pars

Interna in a Patient with Variant Ataxia-Telangiectasia. Movmnt Disords Clncl Practice, 3: 405–408.

doi: 10.1002/mdc3.12287

Hamani C, Aziz T, Bloem BR, Brown P, Chabardes S, Coyne T, Foote K, Garcia-Rill E, Hirsch EC, Lozano AM,

Mazzone PA, Okun MS, Hutchison W, Silburn P, Zrinzo L, Alam M, Goetz L, Pereira E, Rughani A,

Thevathasan W, Moro E, Krauss JK. Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson

Disease: Surgical Anatomy and Terminology. Stereotact Funct Neurosurg. 2016;94(5):298-306.

Hamani C, Lozano AM, Mazzone PA, Moro E, Hutchison W, Silburn PA, Zrinzo L, Alam M, Goetz L, Pereira E,

Rughani A, Thevathasan W, Aziz T, Bloem BR, Brown P, Chabardes S, Coyne T, Foote K, Garcia-Rill E, Hirsch

EC, Okun MS, Krauss JK. Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease:

Surgical Techniques, Side Effects, and Postoperative Imaging. Stereotact Funct Neurosurg. 2016;94(5):307-

319.


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Hamel W, Ko ppen JA, Hariz M, Krack P, Moll CK. The Pioneering and Unknown Stereotactic Approach of

Roeder and Orthner from Go ttingen. Part I. Surgical Technique for Tailoring Individualized Stereotactic

Lesions. Stereotact Funct Neurosurg. 2016;94(4):240-253.

Hariz, M. Once STN DBS, Always STN DBS? – Clinical, Ethical, and Financial Reflections on Deep Brain

Stimulation for Parkinson's Disease. Movmnt Disords Clncl Practice. 2016; 3(3): 285-287.

doi.org/10.1002/mdc3.12292

Jha A, Diehl B, Scott C, McEvoy AW, Nachev P. Reversed Procrastination by Focal Disruption of Medial Frontal

Cortex. Curr Biol. 2016 Nov 7;26(21):2893-2898. doi: 10.1016/j.cub.2016.08.016.

Little S, Tripoliti E, Beudel M, Pogosyan A, Cagnan H, Herz D, Bestmann S, Aziz T, Cheeran B, Zrinzo L, Hariz M,

Hyam J, Limousin P, Foltynie T, Brown P. Adaptive deep brain stimulation for Parkinson's disease

demonstrates reduced speech side effects compared to conventional stimulation in the acute setting. J

Neurol Neurosurg Psychiatry. 2016 Dec;87(12):1388-1389. doi: 10.1136/jnnp-2016-313518.

Little S, Beudel M, Zrinzo L, Foltynie T, Limousin P, Hariz M, Neal S, Cheeran B, Cagnan H, Gratwicke J, Aziz TZ,

Pogosyan A, Brown P. Bilateral adaptive deep brain stimulation is effective in Parkinson's disease. J Neurol

Neurosurg Psychiatry. 2016 Jul;87(7):717-21. doi: 10.1136/jnnp-2015-310972.

Liu JY, Reeves C, Diehl B, Coppola A, Al-Hajri A, Hoskote C, Mughairy SA, Tachrount M, Groves M, Michalak Z,

Mills K, McEvoy AW, Miserocchi A, Sisodiya SM, Thom M. Early lipofuscin accumulation in frontal lobe

epilepsy. Ann Neurol. 2016 Dec;80(6):882-895. doi: 10.1002/ana.24803.

Lonjon N, Russo V, Barbarisi M, Choi D, Allibone J, Casey A. Spinal Cervical Meningiomas: The Challenge

Posed by Ventral Location. World Neurosurg. 2016 May;89:464-73. doi: 10.1016/j.wneu.2016.01.029.

Magown P, Brownstone RM, Rafuse VF. Tumor prevention facilitates delayed transplant of stem cell-derived

motoneurons. Ann Clin Transl Neurol. 2016 Jul 1;3(8):637-49. doi: 10.1002/acn3.327.

Matloob SA, Hyam JA, Thorne L, Bradford R. Improving neurosurgical communication and reducing risk and

registrar burden using a novel online database referral platform. Br J Neurosurg. 2016;30(2):191-4. doi:

10.3109/02688697.2016.1161171.

Matloob SA, Nasir HA, Choi D. Proton beam therapy in the management of skull base chordomas: systematic

review of indications, outcomes, and implications for neurosurgeons. Br J Neurosurg. 2016 Aug;30(4):382-

7. doi: 10.1080/02688697.2016.1181154.

Miller S, Akram H, Lagrata S, Hariz M, Zrinzo L, Matharu M. Ventral tegmental area deep brain stimulation in

refractory short-lasting unilateral neuralgiform headache attacks. Brain. 2016 Oct;139(Pt 10):2631-2640.

Miller S, Watkins L, Matharu M. Long-term outcomes of occipital nerve stimulation for chronic migraine: a

cohort of 53 patients. J Headache Pain. 2016 Dec;17(1):68. doi: 10.1186/s10194-016-0659-0.

Nash R, Elwell V, Brew S, Powell M, Grieve JP. Management strategy for treatment of vasospasm following

transsphenoidal excision of craniopharyngioma. Acta Neurochir (Wien). 2016 Nov;158(11):2105-2108.


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Nowell M, Rodionov R, Zombori G, Sparks R, Rizzi M, Ourselin S, Miserocchi A, McEvoy A, Duncan J. A Pipeline

for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery. J Vis Exp.

2016 May 20;(111). doi: 10.3791/53450.

Nowell M, Sparks R, Zombori G, Miserocchi A, Rodionov R, Diehl B, Wehner T, Baio G, Trevisi G, Tisdall M,

Ourselin S, McEvoy AW, Duncan J. Comparison of computer-assisted planning and manual planning for

depth electrode implantations in epilepsy. J Neurosurg. 2016 Jun;124(6):1820-8. doi:

10.3171/2015.6.JNS15487.

Nowell M, Sparks R, Zombori G, Miserocchi A, Rodionov R, Diehl B, Wehner T, White M, Ourselin S, McEvoy A,

Duncan J. Resection planning in extratemporal epilepsy surgery using 3D multimodality imaging and

intraoperative MRI. Br J Neurosurg. 2016 Dec 8:1-3. doi: 10.1080/02688697.2016.1265086.

Oprych K, Cotfas D, & Choi D. Common olfactory ensheathing glial markers in the developing human olfactory

system. Brain Struct Funct. 2016; 222:1877. doi:10.1007/s00429-016-1313-y

Oswal A, Beudel M, Zrinzo L, Limousin P, Hariz M, Foltynie T, Litvak V, Brown P. Deep brain stimulation

modulates synchrony within spatially and spectrally distinct resting state networks in Parkinson's disease.

Brain. 2016 May;139(Pt 5):1482-96. doi: 10.1093/brain/aww048.

Pote I, Torkamani M, Kefalopoulou ZM, Zrinzo L, Limousin-Dowsey P, Foltynie T, Speekenbrink M, Jahanshahi

M. Subthalamic nucleus deep brain stimulation induces impulsive action when patients with Parkinson's

disease act under speed pressure. Exp Brain Res. 2016 Jul;234(7):1837-48. doi: 10.1007/s00221-016-

4577-9.

Reeves C, Tachrount M, Thomas D, Michalak Z, Liu J, Ellis M, Diehl B, Miserocchi A, McEvoy AW, Eriksson S,

Yousry T, Thom M. Combined Ex Vivo 9.4T MRI and Quantitative Histopathological Study in Normal and

Pathological Neocortical Resections in Focal Epilepsy. Brain Pathol. 2016 May;26(3):319-33. doi:

10.1111/bpa.12298.

Siddiqi AI, Grieve J, Miszkiel K, Baldeweg SE. Tablets or scalpel: Pituitary hyperplasia due to primary

hypothyroidism. Radiol Case Rep. 2016 Feb 17;10(2):1099. doi: 10.2484/rcr.v10i2.1099.

Sidhu MK, Stretton J, Winston GP, McEvoy AW, Symms M, Thompson PJ, Koepp MJ, Duncan JS. Memory

network plasticity after temporal lobe resection: a longitudinal functional imaging study. Brain. 2016

Feb;139(Pt 2):415-30. doi: 10.1093/brain/awv365.

Tan H, Pogosyan A, Ashkan K, Green AL, Aziz T, Foltynie T, Limousin P, Zrinzo L, Hariz M, Brown P. Decoding

gripping force based on local field potentials recorded from subthalamic nucleus in humans. Elife. 2016

Nov 18;5. pii: e19089. doi: 10.7554/eLife.19089.

Toma AK, Watkins LD. Surgical management of idiopathic normal pressure hydrocephalus: a trial of a trial. Br

J Neurosurg. 2016 Dec;30(6):605.


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van Wijk BC, Beudel M, Jha A, Oswal A, Foltynie T, Hariz MI, Limousin P, Zrinzo L, Aziz TZ, Green AL, Brown P,

Litvak V. Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's

disease. Clin Neurophysiol. 2016 Apr;127(4):2010-9. doi: 10.1016/j.clinph.2016.01.015.

Verlaan JJ, Choi D, Versteeg A, Albert T, Arts M, Balabaud L, Bunger C, Buchowski JM, Chung CK, Coppes MH,

Crockard HA, Depreitere B, Fehlings MG, Harrop J, Kawahara N, Kim ES, Lee CS, Leung Y, Liu Z, Martin-

Benlloch A, Massicotte EM, Mazel C, Meyer B, Peul W, Quraishi NA, Tokuhashi Y, Tomita K, Ulbricht C, Wang

M, Oner FC. Characteristics of Patients Who Survived < 3 Months or > 2 Years After Surgery for Spinal

Metastases: Can We Avoid Inappropriate Patient Selection? J Clin Oncol. 2016 Sep 1;34(25):3054-61. doi:

10.1200/JCO.2015.65.1497.

Vongerichten AN, dos Santos GS, Aristovich K, Avery J, McEvoy A, Walker M, Holder DS. Characterisation and

imaging of cortical impedance changes during interictal and ictal activity in the anaesthetised rat.

Neuroimage. 2016 Jan 1;124(Pt A):813-23. doi: 10.1016/j.neuroimage.2015.09.015.

Zavala B, Tan H, Ashkan K, Foltynie T, Limousin P, Zrinzo L, Zaghloul K, Brown P. Human subthalamic nucleus-

medial frontal cortex theta phase coherence is involved in conflict and error related cortical monitoring.

Neuroimage. 2016 Aug 15;137:178-87. doi: 10.1016/j.neuroimage.2016.05.031.


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BOOK CHAPTERS

Chan HW, Uff CE, Chakraborty A, Dorward NL, Bamber JC. “Ultrasound Elastography.” In Francesco Prada,

Luigi Solbiati, Alberto Martegani, Francesco DiMeco (eds.), Intraoperative Ultrasound (IOUS) in

Neurosurgery 2016: From B-mode to Elastosonography, Switzerland: Springer International Publishing

Farmer S, Choi D (2016). Spinal Column and Spinal Cord Disorders (2nd Ed). In Neurology: a Queen square

textbook. April 2016. Wiley Blackwell

Hariz M. History of invasive brain stimulation in psychiatry: Lessons for the current practice of

neuromodulation. In: Clement Hamani, Andres Lozano, Paul Holtzheimer & Helen Mayberg (eds.)

Neuromodulation in Psychiatry. 2016. John Wiley & Sons Ltd.

Hyam J, Pereira E, and Green A. Surgery of the Autonomic Nervous System. 2016. Oxford University Press.

Losseff N, Adams M, Brown M, Grieve J, and Simister R. Stroke and cerebrovascular Diseases (2nd Ed.)

Neurology – A Queen Square textbook. Edited by Charles Clarke, Robin Howard, Martin Rossor, Simon

Shorvon. 2016. Publisher Wiley Blackwell.

OTHER

Hariz M. Where are the results beyond 3 months of the French DBS for OCD study? Letter to the Editor.

Neurology, published online 31 October, 2016.

Zrinzo L, Hariz M, Hyam JA, Foltynie T, Limousin P. Letter to the Editor: A paradigm shift toward MRI-guided

and MRI-verified DBS surgery. J Neurosurg. 2016, 124(4):1135-7.


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Presentations

INTERNATIONAL

Robert Brownstone International Motoneuron Society Bi-annual Meeting, Koç University. Istanbul,

Turkey, Therapeutic Motoneurons

Robert Brownstone Massachusetts General Hospital Neuroscience Grand Rounds, Boston, USA, Neural

circuits for movement: why a functional neurosurgeon cares about the spinal cord

Robert Brownstone Plenary lecture, Motor Systems Symposium, Salk Institute, La Jolla, San Diego, A

Brief History of Spine: from Big Cats to Black Sixes

David Choi Deformity Down Under, Spine Conference, Sydney, Australia:

Craniocervical junction chordomas – How do I do it? Intramedullary spinal cord tumours Trading nerve roots for improved survival – surgery for primary spine tumours Cellular therapies for spinal cord and nerve root repair

David Choi Japanese Spine Society, Sapporo, Japan:

Anterior or posterior approaches to multilevel cervical degenerative disease. Cervical spine tumours. Training neurosurgeons in the UK Primary cervical spine tumours: trading nerve roots for survival. Metastatic disease of the spine

David Choi Korean Spine Tumour Society, Seoul:

Training neurosurgeons in the UK. Primary cervical spine tumours: trading nerve roots for survival. Metastatic disease of the spine

Marwan Hariz Freiburg, Germany, DBS vs lesions in psychiatry

Marwan Hariz European Dystonia Society, Hannover, Germany, The Bertrand procedure in surgical

treatment of cervical dystonia

Marwan Hariz, Würzburg, Germany, DBS emergencies

Marwan Hariz Italian DBS society, Modena, Italy, State of the art in DBS for PD

Marwan Hariz Leksell society meeting, Amsterdam, Lesional surgery for movement disorders

Marwan Hariz Lyon, France, Lesion vs stimulation for Parkinson

Marwan Hariz Bergen, Norway, PhD lecture on DBS

Marwan Hariz Umeå, Sweden, PhD lecture on rehab after traumatic brain injury


15

Marwan Hariz Umeå, Sweden, Pros and cons of microelectrodes in PD surgery

Marwan Hariz Strasbourg, France, Publish or perish in DBS

Marwan Hariz Swedish National DBS Network, Umeå, Sweden, DBS for tremor

Marwan Hariz Swedish National Epilepsy Society Meeting, Umeå, Sweden, DBS for epilepsy: 17 brain

targets

Marwan Hariz XXII Congress of the European Society for Stereotactic and Functional Neurosurgery,

Madrid, Spain:

Keynote Speaker: Psychiatric Neurosurgery Oral presentation: Once STN DBS, always STN DBS? Elekta workshop: Imaging in Stereo Functional Neurosurgery

Jonathan Hyam European Society for Stereotactic & Functional Neurosurgery, Madrid, Spain, The case

against micro electrode recording

Andrew McEvoy MICCAI, Athens, Greece:

Kochan M, Modat M, Vercauteren T, White M, Mancini L, Winston G, McEvoy AW, Thornton J, Yousry T,

Duncan JD, Ourselin S, Stoyanov D. Bilateral weighted adaptive local similarity measure for

registration in neurosurgery

Sparks, R., Zombori, G., Rodionov, R., Nowell, M., Vos, S. B., Zuluaga, M. A., Diehl B., Wehner T,

Miserocchi A, McEvoy, AW, Ourselin, S., Duncan, J. S. Efficient anatomy driven automated

multiple trajectory planning for intracerebral electrode implantation

Ahmed Toma The Eighth Meeting of the International Society for Hydrocephalus and Cerebrospinal

Fluid Disorders (Hydrocephalus 2016), Cartagena, Colombia:

Simon Thompson, Ahmed Toma et al, Creating an NPH pathway for new referrals

Simon Thompson, Ahmed Toma et al, Relationship between intra-abdominal pressure and outcome of surgically treated idiopathic intracranial hypertension (IIH) Patients

Claudia Craven, Ahmed Toma et al, Rostral-caudal CSF markers of inflammation and infection in SAH patients

Claudia craven, Ahmed Toma et al, Ventricular t-tau and aβ-42 levels in 78 shunted INPH patients

Claudia craven, Ahmed Toma et al, Biomarkers in IIH: does csf drainage influence t-tau and aβ-42 Levels?

Simon Thompson, Ahmed Toma et al, Venous sinus stenting for idiopathic intracranial Hypertension - 2 year follow up study of 40 patients

Simon Thompson, Ahmed Toma et al, Telemetric monitoring of ICP within a shunt system. A single Centre experience including the first in vivo comparison versus conventional intraparenchymal monitoring

Ludvic Zrinzo Brazilian Congress of Neurosurgery (31st meeting). Keynote Lecture


16

Ludvic Zrinzo European Association of Neurosurgical Societies Meeting, Athens, Exploring the use of

MRI in DBS surgery, Athens, Greece, Sep 2016

Ludvic Zrinzo European Society for Stereotactic & Functional Neurosurgery Madrid, Spain, Structural

MRI & Advanced Imaging techniques in surgery for movement disorders

Ludvic Zrinzo, Würzburg, Germany, Role of innovative imaging methods (DTI, field modelling)

Ludvic Zrinzo Noble Art of Lesioning, London, Impedance monitoring

http://www.eans.org/


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NATIONAL

18th Clinicopathological Conference on Pituitary Disease

F. Solda', J Grieve, M. Powell, N Dorward, J. Harney, S.E. Baldeweg, P. Bouloux, N. Fersht. Temozolomide in

Aggressive Pituitary Tumours.

Department of Neuroscience, Glasgow University

Robert Brownstone, Spinal Circuits for Motor Learning

Epilepsy Research UK-International Expert Workshop-Tumour associated epilepsy: bridging the

translational gap, Oxford, UK

Andrew McEvoy New surgical concepts for improved seizure control in diffuse low grade gliomas Combined imaging and electrophysiological approaches in tumour associated epilepsy Grand rounds Oxford University, Oxford, UK

Marwan Hariz, The Emperor´s new clothes

MRC Brain Network Dynamics Unit, Oxford University, Oxford, UK

Robert Brownstone, Spinal Microcircuits for Motor Learning

Oxford masterclass in Epileptology-Cutting Edge Investigations and Therapeutics, Oxford, UK

Andrew McEvoy, Emerging surgical therapies in epilepsy SBNS Oral Presentation, Newcastle

Neil Dorward: Ekanayake J, Baudracco I, Cowley P, Dorward NL Hypothalamus-referenced classification of

sella pathology,

Stryker Spine Course, Leeds

David Choi

Masterclass for Spine Tumours, Salford University

David Choi:

Carbon fibre PEEK implants for spine tumour surgery

Surgical approaches to the craniocervical junction for spine tumours


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Spring Meeting of the Society of British Neurological Surgeons, Newcastle

Ahmed Toma S. Thompson, A. Toma and L. Watkins. A new method of non-invasively measuring ICP within a shunt

system: a single centre experience S.A. Matloob, C. Craven, A.K. Toma and L.D. Watkins. Relation between Intra-abdominal pressure and

outcome of surgically treated Idiopathic intracranial hypertension (IIH) patients S. Thompson, I. Baudracco, C. Craven, A. Toma, L. Thorne and L. Watkins. A single centre experience of CSF

drainage via a computerised, pressure lead system H.W. Chan, A.K. Toma and L.D. Watkins. Effect of acetazolamide on intracranial pressure in idiopathic

intracranial hypertension: preliminary study with continuous intracranial pressure monitoring G. Onwordi, E. Ahmed, A. Ogungbemi, A. Toma and F. Robertson. Flow-diverting stents: long-term follow-up C. Craven, I. Baudracco, L.D. Watkins and A.K. Toma. Pharmacological thromboprophylaxis in

angiogramnegative subarachnoid haemorrhage J. Shapey, S. Bapat, A.K. Toma and A. Luoma. An integrated care pathway for patients with chronic subdural

haematoma M.T.C. Poon, A.K. Toma and L.D. Watkins. Publication rate of conference abstracts at Society of British

Neurological Surgeon (SBNS) Meetings Baudracco, A Toma and L Watkins. The use of pharmacological thromboprophylaxis in patients with

secured aneurysms following SAH M.A. Kwakye, M. Poon, A. Toma and L. Watkins. Management and outcome of subarachnoid haemorrhage in

patients with sickle cell disease – a case series and literature review Smedley, N. Yusupov, A. Toma and J. Grieve. Management of incidental cerebral aneurysms single centre

experience, comparison with standard treatment scoring tool (UIATS)

The British Neurovascular Group 7th Annual Meeting - County Durham

Ahmed Toma

Smedley, N. Yusupov, A. Toma and J. Grieve. Management of incidental cerebral aneurysms single centre experience, comparison with standard treatment scoring tool (UIATS)

Craven, I. Baudracco, L.D. Watkins and A.K. Toma. Pharmacological thromboprophylaxis in subarachnoid

haemorrhage.

Victor Horsley: a continuing legacy: commemorating the centenary of Horsley’s death, London

Robert Brownstone, Horsley and Sherrington and the discovery of the pyramidal tract

Marwan Hariz, Horsley and the women pioneers after him


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REGIONAL

QS Neurosurgery Research workshop

Marwan Hariz, Carbon nanotube siRNA silencing of STN in parkisnonian rats

Basal ganglia club

Marwan Hariz, Debunking bunkum in DBS literature

9th International Epilepsy Colloquium, London Andrew McEvoy Technical advances in epilepsy surgery Sciatica - Clinical patterns of radicular compression and red flags Jonathan Hyam UCL Neurology 2016 – Leading Edge Neurology for the Practising clinician David Choi Surgical treatment of craniocervical junction tumours. Wellcome Trust Centre for Surgical and Interventional Sciences Andrew McEvoy & Ventikos Y Biomechanics in Neurosurgery

POSTER PRESENTATIONS

Chan HW, Jacques T, Uff C, Chakraborty A, Dorward N, Bamber J. “Histopathological correlates of Young's

modulus estimated by shear wave elastography in human brain tumours.” Poster presentation. 15th

International Tissue Elasticity Conference, Vermont, USA, 16 – 19 October 2016

Chan HW, Uff C, Chakraborty A, Dorward N, Bamber J. “Clinical application of shear wave elastography for

assisting brain tumour resection.”. Poster presentation. 15th International Tissue Elasticity Conference,

Vermont, USA, 16 – 19 October 2016

Solda’ F, Kitchen N, Grieve J, Powell M, Baldeweg SE, Fersht N. “Treatment of aggressive pituitary tumours

with Temozolomide.” BNOS 2015 Poster presentation – Nottingham, July 2016


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Organisation of Courses and Symposia

18TH CLINICO-PATHOLOGICAL CONFERENCE FOR PITUITARY DISEASE

An annual conference now in its 18th year, predominantly case based meeting with presentation by units around the UK of challenging/interesting patients.

Course organisers: Joan Grieve & Neil Dorward

BIOSURGERY ‘HANDS ON’ WORKSHOP. SPINE AND CRANIAL NEUROSURGERY WET-LAB - VIENNA, AUSTRIA

Update on Neurosurgery, principles of haemostasis and the practical use of products to aid haemostasis in neurosurgery

February 2016

Course organisers: Anna Miserocchi & Andrew McEvoy

EUROPEAN CONTINUED MEDICAL TRAINING

Maximising the Use of Imaging in DBS

May 2016 and June 2016

Course organiser: Ludvic Zrinzo

QUEEN SQUARE SIMULATION COURSES - LONDON

Endoscopic Transsphenoidal Approach and Endoscopic Assisted minimally invasive neurosurgery (March, 2016)

Ventricular Endoscopy (September, 2016)

Course Organisers: Huma Sethi & Laurence Watkins

HUMAN FACTORS IN SURGICAL TRAINING PROGRAMME - LONDON

Engaging people to deliver excellence (October, 2016)

Achieving the best results through others (October, 2016)

Unleashing the power of teamwork (November, 2016)

Solving problems to make the best decision (November, 2016)

Communicating with influence (December, 2016)

Course Organiser: Huma Sethi


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THE NOBLE ART OF LESIONING

A practical course aiming at teaching stereotactic lesional techniques to younger colleagues

Co-organiser: Marwan Hariz

FACULTY PARTICIPATION IN COURSES

IMAGE GUIDED AND IMAGE VERIFIED DBS SURGERY, JOHANNESBURG, SOUTH AFRICA

August 2016

Ludvic Zrinzo

NEW GENERATION NEUROENDOSCOPY TRAINING - BERLIN

Hands on Dissection Course

November 2016

Huma Sethi

NEUROMODULATION IN CLUSTER HEADACHE, STOCKHOLM, SWEDEN

June 2016

Ludvic Zrinzo

QUEEN SQUARE ETV COURSE, ROYAL COLLEGE OF SURGEONS - LONDON

September 2016

Ahmed Toma

ST3 BOOT CAMP - LONDON

November-December, 2016

Huma Sethi


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Public Engagement Activities & Scientific Advisory Boards

PUBLIC ENGAGEMENT ACTIVITIES

1. Ahmed Toma: SBNS CSF group member (Inaugural meeting 19th of April 2016 Newcastle)

2. Ahmed Toma: Steering committee member: IIH Priority Setting Partnership - James Lind Alliance

3. Andrew McEvoy: Patron of the Brain tumour charity Brains Trust

4. Andrew McEvoy: The International League against Epilepsy Commission on Surgical Therapies

5. Anna Miserocchi & Andrew McEvoy: The Guardian newspaper-First Interviews

6. Anna Miserocchi & Andrew McEvoy: Wellcome Institute and BBC Radio3-The Brain with Philip Kerr

7. Anna Miserocchi & Andrew McEvoy: Advisor to author Colin Thubron for the novel ‘Night of Fire’

8. Joan Grieve: Neurosurgical advisor to ‘Understanding Brain Tumour’ booklet by Macmillan Cancer Support

9. Ludvic Zrinzo: Science in the House / Science in the City; Invited speaker to Malta Science Festival in the House of Parliament, Sep 2016

SCIENTIFIC ADVISORY BOARDS

1. Robert Brownstone: Brain Research Trust

2. Ludvic Zrinzo: Netherlands Organisation for Scientific Research & Swiss National Science

Foundation


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Contact Information

Professor Robert Brownstone Brain Research Trust Chair of Neurosurgery

Head of Division

Email: [email protected]

PA Contact Information:

Grace Dray ([email protected])

+44(0)20 3108 9649

Departmental Address

Department of Neurosurgery

Institute of Neurology University College London Queen Square London, UK WC1N 3BG

division of neurosurgery institute of neurology · 2019-12-04 · ul neurosurgery annual report...

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