dmd’21 research honors

May–Jun 2021RESEARCH BULLETIN

Alex Cruz, DMD,received honors in research for his thesis project, “Assessing Access to Hospital-Based Dental Care for Adults with Special Needs” completed under the mentorship of Dr. Nalton Ferraro.

Alex is also the recipient of the 2021 Grace Milliken Award.

Kasey Ha, DMD, received honors in research for her thesis project, “The Microbiology of Pediatric Odontogenic Infections” completed under the mentorship of Dr. Rosalyn Sulyanto.

Ashiana Jivraj, DMD, MBA, received honors in research in the global and community health track for her thesis project, “Applying Value-Based Health Care in a Dental Setting” completed

under the mentorship of Ms. Jane Barrow. Ahiana is also the recipient of the 2021 Harvard Odontological Society Award.

David Kornmehl, DMD, received honors in research for his thesis project, “Assessing Factors That May Influence Performance in a Dental School Operative Course” completed under the mentorship of Dr. Hiroe Ohyama.

Jennifer Lee, DMD, received honors in research in the global and community health track for her thesis project, “Global Health Starter Kit” completed under the mentorship of Dr. Brittany Seymour.

DMD’21 RESEARCH HONORS

CONGRATULATIONS DMD CLASS OF 2021

2 Research Bulletin • May – June 2021 • Harvard School of Dental Medicine

YINGZI YANG, PHD, RECEIVES DEPARTMENT OF DEFENSE AWARD

Yingzi Yang, PhD, professor of Developmental Biology and associate dean for Research at HSDM, received an award from the U.S. Department of Defense for, “Piezo1-Mediated Mechanotransduction as a Key Regulator of Bone Health in Adult Mice.”

There are widespread demands for understanding the pathological and therapeutic development for musculoskeletal disorders. This project addresses musculoskeletal health by investigating the key cellular and molecular mechanisms underpinning bone formation and remodeling

controlled by Piezo1, a key biological force-sensing channel. Human Piezo1 single nucleotide polymorphisms (SNPs) are recently found to be associated with body height reduction and osteoporosis. Dr. Yang will address the following aims: 1. To determine the role of Piezo1 in adult bone homeostasis. 2. To define the role of [Ca2+]i/NO/cGMP/PKG signaling axis in mediating Piezo1-regulated mechanotransduction in bone cells. 3. To identify the osteocyte-intrinsic roles of Piezo1 in promoting bone formation by regulating LCN formation, maintenance and osteocyte activities. Knowing the key roles Piezo1 plays in bone health, Dr. Yang’s mechanistic studies in vitro and in vivo will identify potential biological and therapeutic targets to prevent or treat musculoskeletal disorders caused by musculoskeletal overloading or disuse. Dr. Yang also received a supplemental award for her NIH/NIAMS project, “Molecular Mechanism of Wnt/Planar Cell Polarity Signaling.”

The goal of this project is to evaluate the role of Wnt/planar cell polarity (PCP) signaling in the neurons of the brain in two mouse models of Alzheimer’s Disease (AD). Dr. Yang will examine the expression and activity of PCP in the mouse brain with AD lesions and the role of amyloid precursor protein in Wnt/PCP signaling activation. She will also evaluate alteration of AD phenotypes by the unique Wnt/PCP mutants that she has established to gain critically important insights into pathophysiological mechanisms underlying AD and identify potential targets in Wnt/PCP signaling as an approach for AD treatment.

Research Bulletin • May – June 2021 • Harvard School of Dental Medicine 3

Lau W, Hardt M, Zhang Y, Freire M, Ruhl S. The human salivary proteome Wiki: A community-driven research platform.Journal of Dental Research 2021; May 25.

Matsubara T, Addison W, Kokabu S, Neff L, Horne W, Gori F, Baron R. Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation. Journal of Biological Chemistry 2021;100790.

Pham C, Chen C, Kim D. The effects of using erbium, chromium-doped:yttrium-scandium-gallium-garnet laser on the surface modification, bacterial decontamination, and cell adhesion on zirconia discs. Lasers in Medical Science 2021; Apr 30.

Tavelli L, Barootchi S, Majzoub J, Chan H, Giannobile W, Wang H, Kripfgans O. Ultrasonographic tissue perfusion analysis at implant and palatal donor sites following soft tissue augmentation: A clinical pilot study. Journal of Clinical Periodontology 2021;48(4):602-614.

Taylor D, Yoshida M, Fuller K, Giannobile W, Sfeir C, Wagner W, Kohn D. Translating dental, oral, and craniofacial regenerative medicine innovations to the clinic through interdisciplinary commercial translation architecture. Journal of Dental Research 2021; April 27.

Wang D, Woo SB. Histopathologic spectrum of intraoral irritant and contact hypersensitivity reactions: A series of 12 cases. Head and Neck Pathology 2021; Apr 26.

Xu H, Lee A, Sun L, Naveh G. 3D imaging of PDL collagen fibers during orthodontic tooth movement in mandibular murine model. Journal of Visualized Experiments 2021 Apr 15;(170).

Yates J, Velsko I, Aron F, Posth C, Hofman C, Austin R, Parker C, Mann A, Nägele K, Arthur K, Arthur J, Bauer C, Crevecoeur I, Cupillard C, Curtis M, Dalén L, Díaz M, Díez J, Drucker D, Escribano E, Francken M, Gibbon V, González M, Grande A, Harvati K, Henry A, Humphrey L, Menéndez M, Mihailovi D, Peresani M, Rodríguez S, Roksandic M, Rougier H, Sázelová S, Stock J, Straus L, Svoboda J, Teßmann B, Walker M, Power R, Lewis C, Sankaranarayanan K, Guschanski K, Wrangham R, Dewhirst F, Salazar D, Krause J, Herbig A, Warinner C. The evolution and changing ecology of the African hominid oral microbiome. Proceedings of the National Academy of Sciences USA 2021;118(20):e2021655118.

PUBLICATIONS

DEVELOPMENTAL BIOLOGYJanssen J, Izzi V, Henze E, Cingöz G, Lowen F, KüttnerD, Neumann R, Lenz C, Rosen V, Miosge N. Enhancing the chondrogenic potential of chondrogenic progenitor cells by deleting RAB5C. iScience 2021 May 21;24(5):102464.

Lau W, Hardt M, Zhang Y, Freire M, Ruhl S. The Human Salivary Proteome Wiki: A community-driven research platform. Journal of Dental Research 2021; May 25.

Shan B, Werger M, Huang W, Giddon D. Quantitating the art and science of esthetic clinical success. Journal of the World Federation of Orthodontists 2021; Apr 28.

ORAL MEDICINE, INFECTION AND IMMUNITY

Almazyad A, Alabdulaaly L, Noonan V, Woo SB. Oral hairy leukoplakia: a series of 45 cases in immunocompetent patients. Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2021; Mar 29:4603.

Alvarez C, Abdalla H, Sulliman S, Rojas P, Wu Y, Almarhoumi R, Huang R, Galindo M, Vernal R, Kantarci A. RvE1 Impacts the gingival inflammatory infiltrate by inhibiting the T cell response in experimental periodontitis. Frontiers In Immunology 2021;12:664756.

Blomberg Jensen M, Andreassen C, Jørgensen A, Nielsen J, Juel L, Boisen I, Schwarz P, Toppari J, Baron R, Lanske B, Juul A. RANKL regulates male reproductive function. Nature Communications 2021;12(1):2450.

Chiu C, Chang M, Kantarci A, Van Dyke T, Shi W. Exposure to Porphyromonas gingivalis and modifiable risk factors modulate risk for early diabetic retinopathy. Translational Vision Science & Technology 2021; 10(2):23.

Collins A, Murugkar P, Dewhirst F. Establishing stable binary cultures of symbiotic Saccharibacteria from the oral cavity. Journal of Visualized Experiments 2021; (170).


Lama Alabdulaaly, BDS, DMSc, oral and maxillofacial pathology, received the Dr. James H. Shaw Award. Dr. Alabdulaaly’s thesis project, “Deletion of the Parathyroid Hormone Receptor in Marrow Adipose

Lineage Precursors Prevents Their Negative Regulation of Skeletal Homeostasis” was completed under the mentorship of Dr. Roland Baron and Dr. Francesca Gori.

Diana Wang, DDS, DMSc, oral and maxillofacial pathology, received the Dr. Joseph L.Henry Award. Dr. Wang’s thesis project, “Exploring Early Re-Epithelialization and TET- Mediated 5-Hydroxymethyl-cytosine Epigenetic

Regulation in Oral Mucosal Wound Healing” was completed under the mentorship of Dr. George Murphy.

Hesham Alhazmi, BDS, MS, DMSc, dental public health, received the Lois K. Cohen Award and the Dr. James M.Dunning Award. Dr. Alhazmi’s thesis project, “Socio-Economic Inequalities in Dental Care Utilization Among

the U.S. Population: A Study of Trends From 2010 to 2019” was completed under the mentorship of Dr. Christine Riedy.

Kobie Gordon, DDS, MMSc, dental education, certificate, dental public health, received the Community Service Postdoctoral Award. Dr. Gordon completed his thesis project, “Survey on Antibiotic Stewardship

Training and Programs in Northeast Dental Schools” under the mentorship of Dr. Erinne Kennedy.

CONGRATULATIONS AGE CLASS OF 2021

AGE AWARDS & HONORS


ORAL HEALTH POLICY AND EPIDEMIOLOGY

Elani H, Kawachi I, Sommers B. Medicaid healthy behavior incentives and use of dental services. Health Services Research 2021; May 18.

Hackley D. Climate change and oral health International Dental Journal 2021 Jun;71(3):173-177.

Hackley D, Jain S, Pagni S, Finkelman M, Ntaganira J, Morgan J. Oral health conditions and correlates: A National Oral Health Survey of Rwanda. Global Health Action 2021;14(1):1904628.

Jiang T, Ticku S, Alamer N, Alhazmi H, Harvan R, Riedy C. Context matters: Integration of social determinants of health in AEGD and GPR curricula. Journal of Dental Education 2021; Apr 27.

Joury E, Lee J, Parchure A, Mortimer F, Park S, Pine C, Ramasubbu D, Hillman L. Exploring environmental sustainability in UK and US dental curricula and related barriers and enablers: a cross-sectional survey in two dental schools. British Dental Journal 2021;230(9):605-10.

Nikitara K, Odani S, Demenagas N, Rachiotis G, Symvoulakis E, Vardavas C. Prevalence and correlates of physical inactivity in adults across 28 European countries. European Journal of Public Health 2021; Apr 12.

ORAL AND MAXILLOFACIAL SURGERYFlorian F, Guastaldi F, Cominotte M, Pires L, Guastaldi A, Cirelli J. Behavior of rat bone marrow stem cells on titanium surfaces modified by laser-beam and deposition of calcium phosphate. Journal of Materials Science: Materials in Medicine 2021;32(6):57.

Harris J, Norrlinger J, Dodson T, Ji Y. Hospital quality and safety metrics in oral and maxillofacial surgery. Journal of Oral and Maxillofacial Surgery 2021;(21)00327.

Kim H, Hong X, An Y, Park M, Kim D, Greene A, Padwa B, Hwang N, Lin R, Melero-Martin J. A biphasic osteovascular biomimetic scaffold for rapid and self-sustained endochondral ossification. Advanced Healthcare Materials 2021; Apr.

Klein K, Van Houten T, Wolahan C, Peacock Z. Reflections on Velázquez’s “Don Baltasar Carlos with a Dwarf”. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics 2021; May 13.

Lee C, Hajibandeh J, Tannyhill R, Peacock Z. 3D imaging of PDL collagen fibers during orthodontic tooth movement in mandibular murine model. Journal of Oral and Maxillofacial Surgery 2021;(21)00311-6.

Lee C, Hajibandeh J, Tannyhill R, Peacock Z. Is outpatient management of mandibular fractures associated with inflammatory complications? Journal of Oral and Maxillofacial Surgery 2021; (21)00311-6.

Schipper J, van Lieshout M, Böhringer S, Padwa B, Robben S, van Rijn R, Koudstaal M, Lequin M, Wolvius E. Modelling growth curves of the normal infant’s mandible: 3D measurements using computed tomography. Clinical OralInvestigation 2021; Apr 16.

RESTORATIVE DENTISTRY AND BIOMATERIALS SCIENCESJoury E, Lee J, Parchure A, Mortimer F, Park S, Pine C, Ramasubbu D, Hillman L. Exploring environmental sustainability in UK and US dental curricula and related barriers and enablers: A cross-sectional survey in two dental schools. British Dental Journal 2021;230(9):605-610.

Kornmehl D, Patel E, Agrawal R, Harris J, Ba A, Ohyama H. The effect of gender on student self-assessment skills in operative preclinical dentistry. Journal of Dental Education 2021; May 14.

Stein B, Yoon H, Mattie H, Lee S. Quantitative analysis of the selective pressure impression technique using CAD-CAM technology. Journal of Prosthetic Dentistry 2021; (21)00197-9.

MULTI DEPARTMENTALGrieco P, Da Silva J, Ishida Y, Ishikawa-Nagai S. An in vivo spectrophotometric analysis of gingival acrylic shade guide. Materials (Basel) 2021;14(7).

Kueper J, Tsimbal C, Olsen B, Kaban L, Liao E. SH3BP2-related fibro-osseous disorders of the maxilla and mandible. International Journal of Oral Maxillofacial Surgery 2021; Apr 30.


FACULTY FEATUREZACHARY PEACOCK, MD, DMD

Dr. Peacock graduated summa cum laude from HSDM in 2004, then received his MD degree and residency training in oral and maxillofacial surgery at the University of California, San Francisco. Following his residency training, he completed a fellowship in pediatric oral and maxillofacial surgery (OMFS) at MGH under the mentorship of Dr. Leonard Kaban. Dr. Peacock joined the OMFS faculty in 2010, and was recently promoted to associate professor. He is also co-director of the Cleft and Craniofacial Center, a collaboration between Shriners Hospitals for Children — Boston and MassGeneral Hospital for Children.

Dr. Peacock specializes in the care of patients with craniomaxillofacial deformities and pathology. He is actively involved in clinical and translational research on distraction osteogenesis and the istologic and genomic analysis of benign jaw tumors. As a result of his work, he receives national and international

patient referrals for management of benign maxillofacial lesions. Dr. Peacock has been appointed chair of the American Association of Oral and Maxillofacial Surgeons’ (AAOMS) committee on research. In 2020, he received the William J. Gies Award for research and surgical education from the American Dental Education Association and the AAOMS.

Dr. Peacock developed a technique in collaboration with pediatric neuroradiology at MGH and Boston Children’s Hospital to quantify the amount of synovitis of the temporomandibular joint (TMJ) in children with juvenile idiopathic arthritis. The sensitivity and specificity of this technique has resulted in earlier diagnosis of TMJ involvement and instituted treatment to prevent destruction of the joint and resultant deformity. He also developed a technique for distraction osteogenesis for infants with obstructive sleep apnea helping them avoid, or remove a tracheostomy.

Dr. Peacock has worked tirelessly to provide excellent clinical care that is supported by research directed at improving the outcomes and morbidity of surgical treatment. He is passionate about

teaching and mentoring fellows, residents, and students with an emphasis on problem-based investigation. Dr. Peacock’s ultimate goal is to improve the quality of life of his patients with craniomaxillofacial deformities.

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CHIA-YU JENNIFER CHEN, DDS, DMSc, DIRECTOR OF PREDOCTORALPERIODONTOLOGYThe Department of Oral Medicine, Infection and Immunity is pleased to announce that Dr. Chia-Yu Jennifer Chen has been appointed director of predoctoral periodontology. Dr. Chen seamlessly assumed interim directorship in October 2020 with extraordinary success. Dr. Chen is a 2019 graduate of HSDM's advanced graduate education program in periodontology, earning a DMSc along with her specialty certificate. Following graduation, she joined OMII as a research fellow, then as instructor in July 2020. Dr. Chen has a busy research portfolio and mentors numerous DMD, MMSc and DMSc students.

FERNANDO GUASTALDI, DDS, MSc, PhD, RECEIVES ELEANOR AND MILES SHORE FELLOWSHIPFernando Guastaldi, DDS, MSc, PhD, instructor in Oral and Maxillofacial Surgery (OMFS) and director of the Skeletal Biology Research Center at OMFS, was awarded the Eleanor and Miles Shore Faculty Fellowship. Dr. Guastaldi’s current research focus is “Combinatorial Approach to Cartilage Regeneration in the Temporomandibular Joint.” He is working with Dr. Mark Randolph, assistant professor of surgery and director of the MGH/HMS Plastic Surgery Research Laboratory and Dr. Robert W. Redmond, associate professor of Dermatology and associate chemist in the Wellman Center for Photomedicine at MGH.


SAVE THE DATE: HSDM SCIENCE

SPEAKER SERIESA PUBLICATION OF THE OFFICE OF RESEARCH

Yingzi Yang, PhD Professor of Developmental Biology, Associate Dean for Research, Director of the Biological Sciences in Dental Medicine PhD Program

Dawn M. DeCosta Editor, Design, and Layout

Heather M. Denny Editing

Lia Sgourakes Editing

Ashley SimmonsEditing

If you have questions, content, or comments related to the Research Bulletin, please contact Dawn M. DeCosta, Director of Research Operations at 617-824-0715 (cell);617-432-1121 (office); [email protected].

June 10, 2021 12-1 pm – via Zoom

“Wound Healing: Fibrosis, Fibroblasts, and Regeneration”

Michael Longaker, MD, MBAProfessor and Vice Chair of Plastic and

Reconstructive Surgery, Co-Director, Institute for Stem Cell Biology and Regenerative

Medicine, Stanford University

https://harvard.zoom.us/j/96640107150?pwd=Qm10N3dPT3FBa2ozMy9nK2JZVVRjdz09

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dmd’21 research honors

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