DNA Priming Boosting

NaïveT cells

Central Memory T cells•Enhanced proliferative ability•Limited effector function•Narrow migration pattern

Peripheral Memory / Effector T cells•Reduced proliferative ability•High effector function•Widespread migration pattern

PD-1lo CD62L+

PD-1hi CD62L-

A

PD-1lo CD62L+

ExhaustedT cells

Immune induction / amplification / re-induction, etc.

Anti-Infection,

Tumor

B

Imm

un

ity

Homologous prime-boosting Heterologous prime-boosting

Priming vector => Low PD-1 Priming vector => High PD-1

Highest immunity throughout

Vector inducing central memory PD-1lo T cells

Vector inducing peripheral memory PD-1hi T cells

Time