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©2018SilverberryGenomix.ConfidentialDocument.SampleUser Page1of517

DNAWellnessReportsConfidentialDocument

2018 Silverberry Genomix


ConfidentialityNote

The information contained in this document is privileged and confidential information.

The current DNA Wellness Reports are generated for Sample User.

AboutSilverberryGenomix

Silverberry Genomix is a personalized DNA-based wellness service which utilizes the latest advances ingenomics science and machine learning methods (AI) to analyze more than 140 genetic predispositions.Reports are generated in five packages: Nutrition, Fitness, Skin Care, Allergy Management and PersonalityDevelopment. Silverberry Reports use 23andMe, Ancestry.com or FTDNA Data to generate your wellnessreports.

RevolutionaryGenomicsTechnologyandRigorousScience

Most applications rely on single genetic variation-single genetic trait association studies publicly available.Silverberryâ€™s technology explores a network of genetic variations influencing your potentialpredisposition using an aggregate analysis of more than 2400 scientific studies and enhanced throughlearning artificial intelligence algorithms.

SilverberryStatementofLimitations

DNA-based predisposition is NOT a diagnosis of a disease or condition. Predisposition risk or likelihood is astatistical measure based on the latest advances in genomics science and is provided as an additional layerof information for wellness decision-making. Silverberry recommendations fall within general guidelines forwellness and do not constitute medical advice. Consult with your general physician, dermatologist, personaltrainer or other certified experts before making any major changes to your routines.

For more information visit Terms of Use and Privacy Policy pages.

For information about DNA-Wellness reports visit www.silverberrygenomix.com or [email protected]

Silverberry Genomix. 44 Tehama St, San Francisco, CA 94105. Tel: 415-598-9070


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ListofReportsLongevity Reports

Achilles TendinopathyAnterior Cruciate Ligament RuptureCarb OverconsumptionCollagen BreakdownDifficulty in Losing WeightDrynessExercise Benefits for Blood PressureExercise Benefits for Lowering CholesterolExercise Benefits for Maximal Oxygen Uptake ResponseFacial Pigmented SpotsFat OverconsumptionJoint Injury RiskLean Body Mass PotentialLow Protein Intake RiskLow Resting Metabolic RateLow Vegetable IntakeLow-carb Diet EffectivenessLow-fat Diet EffectivenessMediterranean Diet EffectivenessMemory PerformanceMisophoniaMotion SicknessMuscle Damage RiskMuscle Response to Resistance TrainingMuscle SorenessMuscle Strength LossNoise-induced hearing lossOverall Fitness BenefitsOverall Tendon and Ligament Injury RiskOverweight PotentialPhotoagingResistance to Stomach FluSagging Eyelids RiskSatiety ImpairmentSensitivity to SaltSkeletal Muscle PerformanceSlow Muscle RepairStress FractureYouthfulness

Sports and Exercise ReportsAchilles TendinopathyAerobic performanceAnterior Cruciate Ligament RuptureDifficulty in Losing Weight


101103105107109111113115117119121123126128130132135137139141143145147149

151152154156158160162164166168170172174176178180182184186188190

192193195

Elite Endurance AthletesEnduranceExercise AversionExercise Benefits for Blood PressureExercise Benefits for Lowering CholesterolExercise Benefits for Maximal Oxygen Uptake ResponseHeartbeat Reduction DifficultyJoint FlexibilityJoint Injury RiskLean Body Mass PotentialLower Exercise Benefits for Heart Pump FunctionMuscle CrampingMuscle Damage RiskMuscle Response to Resistance TrainingMuscle SorenessMuscle Strength LossMuscular StrengthOverall Fitness BenefitsOverall Tendon and Ligament Injury RiskOverweight PotentialPowerSkeletal Muscle PerformanceSlow Muscle RepairStress Fracture

Skin Care ReportsAcneCollagen BreakdownContact skin sensitivityDermal SensitivityDrynessFacial Pigmented SpotsPhotoagingPollution Defense impairmentPoor tanning abilityProtection from Skin CelluliteSagging Eyelids RiskSensitivity to SunSkin Antioxidant DeficiencySkin Barrier SensitivitySkin Detoxification impairmentSkin GlycationSkin InflammationSkin RosaceaSkin Stretch MarksYouthfulness

Personality ReportsAddictive PersonalityAgreeableness


197199201203205207209211213215217219221223225227229231233235

237239241243246248250252254256258260262264267269271273275278280282284286288290292294296

Anger ResponseCreativityEmpathyExperiential Learning ImpairmentExploratory BehaviorExtraversionImpulsivityLeadership PotentialMathematical AptitudeMemory PerformanceMisophoniaMorning PersonMusic Performance AptitudeMusical CreativityOptimismReading AptitudeSeasonalitySociabilityWarrior PersonalityWorrier Personality

Weight Management ReportsAerobic performanceCarb OverconsumptionDifficulty in Losing WeightExercise AversionExercise Benefits for Lowering CholesterolExercise Benefits for Maximal Oxygen Uptake ResponseFat OverconsumptionFat Taste PerceptionJoint Injury RiskLean Body Mass PotentialLow Protein Intake RiskLow Resting Metabolic RateLow-carb Diet EffectivenessLow-fat Diet EffectivenessMediterranean Diet EffectivenessMonounsaturated Fats Increased BenefitsMuscle Response to Resistance TrainingMuscle Strength LossOverall Fitness BenefitsOverweight PotentialPolyunsaturated Fats Increased BenefitsRisk from Saturated FatsSatiety ImpairmentSlow Muscle RepairSnackingStarch MetabolismSweet ToothTrans Fats Sensitivity


298300302304306308310313315317319321324326329331334336338340342344346348350

352353355357359361363365367369371

373374376378380382385388390392394397

Allergy ReportsAllergy to CockroachesAllergy to Dust MitesAllergy to EggsAllergy to MilkAllergy to MoldAllergy to PeanutsAllergy to PetsBirch Pollen Allergy ResistanceBitter Taste SensitivityGlutathione DeficiencyGluten SensitivityGrass Allergy ResistanceHay FeverHistamine IntoleranceLactose IntoleranceMisophoniaMotion SicknessMugwort Allergy ResistanceNoise-induced hearing lossResistance to Stomach FluSeasonalitySensitivity to BenzeneSensitivity to MercurySensitivity to PCB

Basic Wellness ReportsCaffeine Metabolism ImpairmentDrynessExploratory BehaviorJoint FlexibilityMediterranean Diet EffectivenessOverall Fitness BenefitsOverweight PotentialPoor tanning abilityReading AptitudeSeasonality

Nutrition ReportsCaffeine Metabolism ImpairmentCalcium DeficiencyCarb OverconsumptionCholine DeficiencyCoenzyme Q10 DeficiencyCopper DeficiencyFat OverconsumptionFat Taste PerceptionGeneral Food SensitivitiesGluten SensitivityIron Deficiency


399401404406

undefined408411413415418420422424426428430432434436438440442444446448450452454456458460462464466468470472474

476477479481484486488490492494496

Iron OverloadLactose IntoleranceLow Protein Intake RiskLow Resting Metabolic RateLow Vegetable IntakeLow-carb Diet EffectivenessLow-fat Diet EffectivenessLutein and Zeaxanthin DeficiencyLycopene DeficiencyMagnesium DeficiencyMediterranean Diet EffectivenessMonounsaturated Fats Increased BenefitsPhosphorus DeficiencyPolyunsaturated Fats Increased BenefitsRisk from Saturated FatsSatiety ImpairmentSelenium DeficiencySensitivity to SaltSnackingStarch MetabolismSweet Snack PreferenceSweet ToothTrans Fats SensitivityVitamin A (Carotene) DeficiencyVitamin A (Retinol) DeficiencyVitamin B1 DeficiencyVitamin B12 DeficiencyVitamin B2 DeficiencyVitamin B3 DeficiencyVitamin B5 DeficiencyVitamin B6 DeficiencyVitamin B7 DeficiencyVitamin B9 DeficiencyVitamin C DeficiencyVitamin D DeficiencyVitamin E DeficiencyVitamin K DeficiencyZinc Deficiency

Vitamin ReportsCholine DeficiencyLutein and Zeaxanthin DeficiencyLycopene DeficiencyVitamin A (Carotene) DeficiencyVitamin A (Retinol) DeficiencyVitamin B1 DeficiencyVitamin B12 DeficiencyVitamin B2 DeficiencyVitamin B3 DeficiencyVitamin B5 Deficiency


498500502504506508510

Vitamin B6 DeficiencyVitamin B7 DeficiencyVitamin B9 DeficiencyVitamin C DeficiencyVitamin D DeficiencyVitamin E DeficiencyVitamin K Deficiency


In this package, you will find a collection of traits in 5 areas that are directly or indirectly related to longevity.Those areas include nutrition, weight management, skin care, managing sensitivities and cognitivecapabilities such as memory performance.

LongevityReports39 Reports in 6 groups

NutritionandWeightManagementHave you wondered which diet is more effective for your unique biology? How youprocess carbs, fat and protein are unique to your body's enzymatic processes and yourgenetic makeup has a strong influence on what works best for sustainable weightcontrol. You learn more about how your genetics impacts your diet and metabolism inthis section.

SkinCareYour skin changes as you age. You might notice wrinkles, age spots and dryness. Yourskin also becomes thinner and loses fat, making it less plump and smooth. Sunlight is amajor cause of skin aging. You can protect yourself by staying out of the sun when it isstrongest, using the right sunscreen and wearing protective clothing. In this section, youcan explore how your genetic makeup impacts your skin as you age and get guidelineon what to do about it.

ExerciseBenefitsHave you asked yourself the question of why some people respond to an aerobicworkout routine by becoming incredibly fit, whereas others who exercise just as hard formonths end up no fitter than the beginning? How much each of us benefits fromexercise depends strongly on genetic factors. In this section you can gain insights onwhat the actual benefits of exercise can be on your unique biology.

InjuryRisksWhile we all realize that exercise has tremendous benefits for our health, we also needto be aware of injury risks that come with doing the wrong kinds of exercises. Ourtendons and joints are structured differently. Explore how your unique genetic makeupmakes you more or less vulnerable to tendon and/or joint injury risks and getrecommendations on what exercises and routines to engage in or avoid.


CognitiveCapabilitiesThere are various studies regarding aging and cognitive capabilities, such as memoryperformance. Some of the studies also links physical activity to mental performance. Getinsights on how your genetics may impact your cognitive capabilities with regards topredispositions for Memory Performance, Reading Aptitude and more.

SensitivitiesIn addition to food, outdoor, indoor and chemical allergies and sensitivities, your geneticmakeup can also influence other sensitivities that impact your life. Explore how yourunique genetic makeup impacts your potential predisposition as you age for painsensitivity, noise-induced hearing loss and more.


SUMMARY

Your genetic risk for Achilles tendon injury seems to be low so you need to take ordinary measuresto protect your tendons.Try the following exercise to strengthen your calf muscles:

Use a resistance loop band or tie a long band into a loop 12" to 15" or 30 to 40 cm indiameter. Then, loop the resistance band around your foot with your toes pointed up towardthe ceiling. Holding the band tight, push your foot and ankle down against the band as far ascomfortable.Hold the position for a second, then return back to your starting position slowly. Do 10repetitions, then switch to your other foot.

Avoid an abrupt change of exercise intensity.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Achilles Tendinopathy2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 15% of the population and is consideredstatistically low compared to the general population.

WHATISACHILLESTENDINOPATHY

Achilles tendon injury includes degenerative and painful conditions that affect athletes in a wide range ofsports, including up to 20% of runners. This is a multifactorial condition for which various genetic risk factorshave been identified. Genetic variants in the FBGN2, TNC and ADAMTS14 (metallopeptidase withthrombospondin) gene contribute to the reisk of achilles tendinopathy, while genetic variant in the MMP3 hasbeen found to be protective.

ACHILLESTENDINOPATHY

YOU:

15NORMAL


WHATTODO

Your genetic risk for Achilles tendon injury seems to be low so you need to take ordinary measures toprotect your tendons.

Try the following exercise to strengthen your calf muscles:Use a resistance loop band or tie a long band into a loop 12" to 15" or 30 to 40 cm in diameter.Then, loop the resistance band around your foot with your toes pointed up toward the ceiling.Holding the band tight, push your foot and ankle down against the band as far as comfortable.

Hold the position for a second, then return back to your starting position slowly. Do 10repetitions, then switch to your other foot.

Avoid an abrupt change of exercise intensity.Try to minimize high-impact sports, such as running which pose a higher risk for Achilles tendoninjury.Switch to low-impact sports, such as walking, biking or swimming, which can both strengthen yourmuscles and pose less of an injury risk.

NATUREVS.NURTURE

Note that there are many items to consider when reading your genetics-based wellness assessment. Yourgenetics is only one component, your nurture environment and your current lifestyle choices are othercomponents that influence your well being. DNA-based predisposition is NOT a diagnosis of a disease orcondition and can not be used for treatment. Predisposition risk or likelihood is a statistical measure basedon the latest advances in genomics science and is provided as an additional layer of information for wellnessdecision-making. Silverberry reports and recommendations fall within general guidelines for wellness and donot constitute medical advice. Consult with your general physician, dermatologist, personal trainer or othercertified healthcare providers before making any major changes to your routines.

GENETICVARIATIONS

There are 2 genes within your DNA that influence this trait.You have 1 contributing and 1 inhibiting genes that affect this trait.

Contributing genetic variations:

rs2104772

Inhibiting genetic variations:

rs679620

http://useast.ensembl.org/Homo_sapiens/Variation/Explore?v=rs2104772



SUMMARY

You are at low genetic risk for anterior cruciate ligament (ACL) ruptures, but you may still benefitfrom exercises that require balance, power and agility.Jumping and balance exercises also help improve neuromuscular conditioning and muscularreactions and decrease the risk of ACL injury.It has also been suggested that drinking water before and after exercise may be beneficial for ACLinjury prevention.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Anterior Cruciate LigamentRupture4 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISANTERIORCRUCIATELIGAMENTRUPTURE

Anterior cruciate ligament (ACL) ruptures are considered to be the most severe joint injury in sports and isvery common in a sporting population. Athletes who participate in high demand sports like soccer, football,and basketball are more likely to injure their anterior cruciate ligaments. Athletes are involved with suddendeceleration of the body from jumping and forward running while the knee is in a shallow flexion angle. Onthe other hand, ACL injuries are not common among athletes involved in endurance sports, such as running,swimming, biking. About half of all injuries to the anterior cruciate ligament occur along with damage to otherstructures in the knee, such as articular cartilage, meniscus, or other ligaments.

Injured ligaments are considered "sprains" and are graded on a severity scale.

Grade1Sprains. The ligament is mildly damaged in a Grade 1 Sprain. It has been slightly stretched, but isstill able to help keep the knee joint stable.

Grade2Sprains. A Grade 2 Sprain stretches the ligament to the point where it becomes loose. This is oftenreferred to as a partial tear of the ligament.

ANTERIORCRUCIATELIGAMENTRUPTURE

YOU:

10NORMAL


Grade3Sprains. This type of sprain is most commonly referred to as a complete tear of the ligament. Theligament has been split into two pieces, and the knee joint is unstable.

There are some genetic variations that are commonly found in individuals with higher risk of ACL ruptures.

WHATTODO

You are at low genetic risk for anterior cruciate ligament (ACL) ruptures, but you may still benefit fromexercises that require balance, power and agility.

Jumping and balance exercises also help improve neuromuscular conditioning and muscularreactions and decrease the risk of ACL injury.It has also been suggested that drinking water before and after exercise may be beneficial for ACLinjury prevention.Some simple tips to reduce the risk of ACL ruptures:Alwayswarmupbeforeplaying. Get blood circulating to your muscles and joint before you startyour game or practice.

Stretch. Being flexible enough to move freely can help you maintain ideal form. Includestretches for your thighs, calves, and hips, and pay particular attention to any areas that areespecially tight.Strengthen. Having adequate strength in your hips and thighs is key to providing supportfor your knees and preventing ACL injuries. Squats and lunges are just a couple of exercisesthat can build strength.Balance. Many injuries occur when an athlete is off-balance. Like anything, balance getsbetter with practice. Your gains in stability will pay off on the playing field.Agility-ChangingDirection:Run to a line or cone, plant your outside foot without letting your knee collapse inward tochange direction.

Move in patterns that take you front to back, side to side and diagonally.Start byrunning slowly so you can concentrate on good position.Pick up the pace and maintain good technique.

As always consult with a personal trainer before changing your exercise routines.

NATUREVS.NURTURE



GENETICVARIATIONS



rs495366


rs1800012, rs970547, rs240736






SUMMARY

You do not have genetic predispositions that would indicate an impulse for higher carb consumption. Youshould be fine consuming carbs up to the levels prescribed by the FDA for the average population.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Carb Overconsumption5 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 50% of the population and is consideredstatistically low compared to the general population.

WHATISCARBOVERCONSUMPTION

Carbohydrates serve as the primary energy source for the brain and its role as a source of kilocalories tomaintain body weight. Individuals with specific genetic variations are more likely to crave carbs than others.This may result in over-consumption of carbs for such individuals. The recommended intake forcarbohydrate intake is 45-65% of total calories intake. Starch and sugar are the major types ofcarbohydrates. Grains and vegetables (corn, pasta, rice, potatoes, breads) are sources of starch. Naturalsugars are found in fruits and juices. Sources of added sugars are soft drinks, candy, fruit drinks, anddesserts.

WHATTODO


CARBOVERCONSUMPTION

YOU:

50NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Carb Overconsumption by checking out the following articles:

Every Thing about Carbohydrates

GENETICVARIATIONS



rs838133, rs1542608, rs4702718, rs8019546


rs2840445

https://fnic.nal.usda.gov/food-composition/macronutrients/carbohydrates







SUMMARY

Consume collagen-rich foods like bone broth Reduce exposure to environmental factors (such as smoking, chlorinated water) that increase MMPlevelsUse skin care products rich in polyphenols, carotenoids, or flavonoids: topical agents such as asretinoids, including retinol (vitamin A), bioflavonoids including the proanthocyanidins from grapeseed extract, the polyphenols from green and white teas, soy phytoestrogens

MYASSESMENT

You seem to have elevated genetic predispositions risk for Collagen Breakdown2 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISCOLLAGENBREAKDOWN

Skin elasticity is the skin's ability to stretch and revert to its original form without developing wrinkles andimperfections. It is determined by collagen that makes up to 75 percent of our skin. Your skin's smoothness,firmness and elasticity depend on the balance between collagen synthesis and its breakdown. Levels ofMMPs increase in the course of normal aging, exposure to environmental factors, including UV, and irritation.In addition, genetic variants increase activity of MMPs contributing to accelerated loss of collagen andpremature skin aging.

COLLAGENBREAKDOWN

YOU:

95ELEVATED


WHATTODO

Consume collagen-rich foods like bone broth Reduce exposure to environmental factors (such as smoking, chlorinated water) that increase MMPlevelsUse skin care products rich in polyphenols, carotenoids, or flavonoids: topical agents such as asretinoids, including retinol (vitamin A), bioflavonoids including the proanthocyanidins from grapeseed extract, the polyphenols from green and white teas, soy phytoestrogensSip drinkable collagen for glowing skin Consider taking supplements that boost collagen production or inhibit MMPs. Think plypodiumleucotomos (available in oral capsules), lutein, and hops extract (xanthohumol)

NATUREVS.NURTURE


LEARNMORE

Learn more about Collagen Breakdown by checking out the following articles:

Is It Possible to Naturally Improve Skin Elasticity? Is It Possible to Naturally Improve Skin Elasticity? 7 Tips for Buying the Best Collagen Supplement Is drinking collagen the secret to a glowing complexion?

GENETICVARIATIONS

There are 2 genes within your DNA that influence this trait.You have 2 contributing and No inhibiting genes that affect this trait.


rs1799750, rs3918261


No inhibiting Variations Present was found

http://www.livestrong.com/article/537104-how-to-naturally-improve-skin-elasticity/

http://www.livestrong.com/article/281518-how-to-drink-collagen-for-the-skin/

http://www.renewalliance.com/blog/7-tips-for-buying-the-best-collagen-drink-beauty-supplement

http://www.wellandgood.com/good-looks/drinkable-collagen-skin-benefits/




SUMMARY

You seem to have a higher genetic-based predisposition towards weight loss difficulty, so we wouldrecommend that you consider an intake of up to 20% less than the recommended caloricrestrictions recommended by tools like the MayoClinicHealthyWeightPyramid.. However do notgo under 1200 calories of intake, since this will result in potential nutrient deficiencies for yourbody. Make sure to follow the directions of the tool with regards to the optimal intake and eat a healthy andbalanced diet. One of the problems with dieting is that people count calories but forget aboutessential vitamins and minerals.Make sure to exercise. numerous studies show that diet alone may not be sufficient for long-termweight-loss. You may need to stay motivated longer to see the impact of your new diet and exerciseplan.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Difficulty In Losing Weight6 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically risky compared to the general population.

WHATISDIFFICULTYINLOSINGWEIGHT

Not everyone loses weight at the same rate. Some people lose a few pounds a week after they follow anycalorie restrictive diet, while others attempt all kinds of trendy weight-loss diets, but do not see results.Studies found that genetics is, at least, in part to blame for difficulty in losing weight. Studies have shownthat carriers of some genetic variations have more difficulties losing weight and improving their metabolichealth than people with reference, or common, alleles. People with genetic variants associated with obesity,sensitivity to fat (FTO, PPARG), type 2 diabetes (TCF7L2) emotional eating (CLOCK, SIRT1) and foodaddiction (DRD2), do not lose weight as easily as other people while on the same diet and exercise regiment.It is important to remember that genetics plays role in weight loss and weight maintenance. Some medicalconditions and medications can also hinder weight loss. The most common ones are hypothyroidism,hormonal changes in women, chronic stress and depression.

DIFFICULTYINLOSINGWEIGHT

YOU:

85ELEVATED

http://www.mayoclinic.org/healthy-lifestyle/weight-loss/in-depth/weight-loss/itt-20084941


WHATTODO

You seem to have a higher genetic-based predisposition towards weight loss difficulty, so we wouldrecommend that you consider an intake of up to 20% less than the recommended caloric restrictionsrecommended by tools like the MayoClinicHealthyWeightPyramid.. However do not go under 1200calories of intake, since this will result in potential nutrient deficiencies for your body.

Make sure to follow the directions of the tool with regards to the optimal intake and eat a healthy andbalanced diet. One of the problems with dieting is that people count calories but forget aboutessential vitamins and minerals.Make sure to exercise. numerous studies show that diet alone may not be sufficient for long-termweight-loss. You may need to stay motivated longer to see the impact of your new diet and exerciseplan.If you are still struggling with weight loss, monitor your alcohol intake.Consider discussing with your physician whether any medications or health conditions may interferewith your weight-loss efforts.

NATUREVS.NURTURE


LEARNMORE

Learn more about Difficulty In Losing Weight by checking out the following articles:

Why You Canâ€™t Lose weight on a diet? Why Aren't You Losing Weight?


http://www.nytimes.com/2016/05/08/opinion/sunday/why-you-cant-lose-weight-on-a-diet.html

http://www.webmd.com/diet/obesity/features/why-arent-you-losing-weight#1


GENETICVARIATIONS



rs9939609, rs7903146, rs1440581, rs1801282, rs1800497, rs10830963










SUMMARY

Take good care of your skin to keep it well-hydratedUse good quality moisturizer: lighter for summer, richer for winterExfoliate your skin regularly

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for DrynessNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 45% of the population and is consideredstatistically low compared to the general population.

WHATISDRYNESS

Balanced level of hydration is absolutely fundamental for healthy facial and body skin. Aquaporin channels, afamily of integral cell membrane proteins, play central role in keeping our skin hydrated by allowing themovement of water and glycerol across the cell membrane. The expression of aquaporin channels in humanskin is strongly affected by aging, chronic sun exposure, and inflammation. The most abundant (and beststudied) aquaporin in the skin is the AQP3 gene. It transports water, glycerol and small solutes (urea) acrossthe plasma membrane, regulates skin hydration, skin barrier recovery and wound healing. Another group ofgenes expressed in skin are called claudins. They are tight junction membrane proteins that form paracellularbarriers and pores that determine tight junction permeability. Genetic variations in the AQP3 and CLDN1genes result in their lower expression and reduced activity in epidermis leading to impairments in skinintrinsic hydration capacity, and skin dryness.

WHATTODO

Take good care of your skin to keep it well-hydratedUse good quality moisturizer: lighter for summer, richer for winterExfoliate your skin regularlyHydrate from inside outFind out about your genetic-based predisposition to impaired skin barrier function, overall dermalsensitivity and contact dermal sensitivity

DRYNESS

YOU:

45NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Dryness by checking out the following articles:

How to Hydrate Facial Skin Aquaporins - water channels in the skin Does drinking water cause hydrated skin?

GENETICVARIATIONS

There are No genes within your DNA that influence this trait.You have No contributing and No inhibiting genes that affect this trait.


No Contributing Variations Present was found



http://www.livestrong.com/article/174819-how-to-hydrate-facial-skin/

http://www.kanebo.com/science/skin/aquaporin.html

http://www.mayoclinic.org/healthy-lifestyle/adult-health/expert-answers/hydrated-skin/faq-20058067


SUMMARY

You will probably achieve moderate improvements in your blood pressure thorugh moderateexercise. Regular exercise of at least 30 minutes per day, together with a healthy diet, will most likely result inlower blood pressure over time. Exercises that are useful for lowering your blood pressure include: Brisk walking , Cycling,Swimming, Dancing, Mowing the lawn, Tennis and Jogging.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Exercise Benefits ForBlood Pressure1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISEXERCISEBENEFITSFORBLOODPRESSURE

For most people, moderate-intensity exercise has been shown to lower blood pressure. In fact, aerobicexercise training is generally recommended as lifestyle therapy to prevent, treat and control hypertension.General guidelines call for at least half an hour of low intensity aerobic exercises, which helps to decreaseblood pressure. There is large variability in the individual response to the anti-hypertensive effect of exercise,and much of it is explained by genetic variations. Individuals with predisposition to increased hypertensionresponse, get to lower their blood pressure faster than the average population. For such individuals, thebenefits of this 30 minute exercise are more noticeable than for the average population.

EXERCISEBENEFITSFORBLOODPRESSURE

YOU:

25TYPICAL


WHATTODO

You will probably achieve moderate improvements in your blood pressure thorugh moderate exercise. Regular exercise of at least 30 minutes per day, together with a healthy diet, will most likely result inlower blood pressure over time. Exercises that are useful for lowering your blood pressure include: Brisk walking , Cycling,Swimming, Dancing, Mowing the lawn, Tennis and Jogging.Exercises you should avoid for blood pressure reduction: Weight lifting and sprinting. If you need to lower your blood pressure through exercise, you may want to increase its intensityunder the supervision of your physician or trainer. Please note that physical activity will temporarily cause your blood pressure to rise before it lowersyour blood pressure over time. So if you have high blood pressure, it is important to increase fitnessactivities gradually, and not to put too much strain on your heart. If your blood pressure is very high, you should not start any new activity without consulting yourdoctor.

NATUREVS.NURTURE


LEARNMORE

Learn more about Exercise Benefits For Blood Pressure by checking out the following articles:

Exercise: A drug-free approach to lowering high blood pressure

GENETICVARIATIONS



rs62205366



http://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/high-blood-pressure/art-20045206



SUMMARY

While you may not have genetic predispositions for cholestrol reduction benefits through exercise,you can still achieve better cardiovascular health by engaging in regular exercise and keepiing a low-cholstrol diet. Check your Nutrition report to see if you have predispositions that affect your fatconsumption and fat processing.The AHA suggests at least 150 minutes of moderate exercise or 75 minutes of vigorous exercise perweek. If you mix and match the two, you can count every minute of vigorous activity as two minutesof moderate activity. Moderate exercises (where you can easily maintain a conversation) include: Walking briskly (3 milesper hour or faster), Bicycling (10 miles per hour or slower), and gardening.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Exercise Benefits ForLowering CholesterolNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 15% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISEXERCISEBENEFITSFORLOWERINGCHOLESTEROL

Research has shown that exercise stimulates enzymes that help move bad cholesterol from the blood to theliver, allowing it to be excreted as bile. It is also stipulated that exercise increases the size of the proteinparticles that carry cholesterol through the blood, reducing the possibility that smaller particles may clogarteries. People with some genetic variants will have good results at increasing levels of good cholesterol byexercise alone, while carriers of other genetic variants are less likely to succeed to lower bad cholesterollevels by exercise alone.

EXERCISEBENEFITSFORLOWERINGCHOLESTEROL

YOU:

15TYPICAL


WHATTODO

While you may not have genetic predispositions for cholestrol reduction benefits through exercise, you canstill achieve better cardiovascular health by engaging in regular exercise and keepiing a low-cholstrol diet.Check your Nutrition report to see if you have predispositions that affect your fat consumption and fatprocessing.

The AHA suggests at least 150 minutes of moderate exercise or 75 minutes of vigorous exercise perweek. If you mix and match the two, you can count every minute of vigorous activity as two minutesof moderate activity. Moderate exercises (where you can easily maintain a conversation) include: Walking briskly (3 milesper hour or faster), Bicycling (10 miles per hour or slower), and gardening. Vigorous exercises (where you breathe heavily) include Racewalking, running, swimming laps,playing tennis, aerobic dancing, professional biking and hiking uphill.Consult with a fitness professional befiore engaging in strenous exercise.

NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY

Your higher than average benefits likelihood for VO2max means you can increase your breathingcapacity faster than the average individual by exercising. To estimate your current VO2 Max as a baseline and measure its improvements as you exercise,clickheretousetnyofthefourfollowingcalculators(externallink).To improve your VO2 Max, you can engage in consistent aerobic conditioning.

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for ExerciseBenefits For Maximal Oxygen Uptake Response14 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 90% of the population and is consideredstatistically advantaged compared to the general population.

WHATISEXERCISEBENEFITSFORMAXIMALOXYGENUPTAKERESPONSE

VO2 max (also maximal oxygen consumption, maximal oxygen uptake, peak oxygenuptake or maximal aerobic capacity) is the maximum rate of oxygen consumption as measured duringincremental exercise, most typically on a motorized treadmill. One of the exercise benefits is improvement inmaximal oxygen uptake response. When you exercise your muscles are working harder than normal and, asa result, they require more energy than normal. Since the ATP energy used by your muscles is generatedwith the aid of oxygen, it follows that an increase in exercise intensity will result in an increase in muscularoxygen demands. Therefore, increased exercise intensity ultimately corresponds to an increased VO2. Thisis the reason that your breathing gets progressively faster and deeper as your exercise intensity increases,your body is trying to provide more oxygen to your working muscles so that they can generateenough ATP energy to keep you moving. People with differences in genetics, gender, age and fitness staterespond differently to the same exercise training program. At least 50% of these differences have beenfound to be due to genetic variations.

EXERCISEBENEFITSFORMAXIMALOXYGENUPTAKERESPONSE

YOU:

90ADVANTAGED

http://www.shapesense.com/fitness-exercise/calculators/vo2max-calculator.shtml


WHATTODO

Your higher than average benefits likelihood for VO2max means you can increase your breathing capacityfaster than the average individual by exercising.

To estimate your current VO2 Max as a baseline and measure its improvements as you exercise,clickheretousetnyofthefourfollowingcalculators(externallink).To improve your VO2 Max, you can engage in consistent aerobic conditioning. For more serious athletes and under the supervision of a trainer you can also choose a faster way toimprove your VO2 max which is to run intervals at the fastest speed you can maintain for about fiveminutes, followed by 10 minutes of rest, starting with once and increasing it to four times in onehour. Consult with your trainer before changing anything in your exercise regimen.

NATUREVS.NURTURE


GENETICVARIATIONS



rs12115454, rs2003298, rs884736, rs6552828, rs2428514, rs959066, rs2523849, rs2272040,rs10500872, rs12580476, rs2517518, rs4973706, rs4952535, rs4938561



















SUMMARY

Follow general guidelines to protect your facial skin from the UV exposureUse sunscreen. Apply moisturizer with SPF throughout the yearMonitor any changes in thei color, size or texture of moles and other skin lesions

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Facial Pigmented Spots2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically low compared to the general population.

WHATISFACIALPIGMENTEDSPOTS

Facial pigmented spots (solar lentigines and seborrheic keratosis) are a common feature of aging skin, andusually result sun exposure. With age, the repeated UV exposure causes melanin, a compound responsiblefor pigmentation as well as protecting the skin, to cluster or clump together, forming an area of hyper-pigmentation. Pigmented age spots develop earlier and are more pronounced in Asian than in Caucasianskin. While there are some similarities in manifestation of pigmented spots in different populations(determined by the MC1R ASIP IRF4 BNC2 genes), there are also ethnic differences. The SLC45A2 genehave been found to be associated with pigmented spots in Asian but not in Caucasian women.

WHATTODO

Follow general guidelines to protect your facial skin from the UV exposureUse sunscreen. Apply moisturizer with SPF throughout the yearMonitor any changes in thei color, size or texture of moles and other skin lesionsVisit dermatologist regularly to do a full-body check

FACIALPIGMENTEDSPOTS

YOU:

5NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Facial Pigmented Spots by checking out the following articles:

How to Get Rid of Dark Spots on Your Face Pigmentation explained: Everything you need to know How to Remove Brown Pigment Spots From the Face

GENETICVARIATIONS



rs463701


rs3843706

http://www.wikihow.com/Get-Rid-of-Dark-Spots-on-Your-Face

http://www.cosmopolitan.co.uk/beauty-hair/a19890/what-is-pigmentation-and-how-to-treat-it/

http://www.livestrong.com/article/181821-how-to-remove-brown-pigment-spots-from-the-face/




SUMMARY

Follow general recommendations for daily consumption of fats. Recommended daily calories fromfat should constitute 25-35%.Ensure that your diet is full of good (mono-unsaturated and poly-unsaturated) fats and watch for thebad (saturated) fats.If you are not a vegetarian, substitute fatty fish (salmon, mackerel,tuna) instead of meats high insaturated fat.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Fat Overconsumption2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISFATOVERCONSUMPTION

Fat is a dense source of energy and essential fatty acids, and it also facilitates the absorption of fat solublevitamins. However too much fat consumption may result in heart disease and becoming overweight. Severalrecent studies in the US and Europe indicate that the percentage of energy derived from saturated fat isabove the acceptable range, while the opposite was observed for mono-unsaturated and poly-unsaturatedfat. Several genetic variations are known to influence the amount of fat consumed by individuals and theiroverall fat intake craving.

WHATTODO

Follow general recommendations for daily consumption of fats. Recommended daily calories from fat shouldconstitute 25-35%.

Ensure that your diet is full of good (mono-unsaturated and poly-unsaturated) fats and watch for thebad (saturated) fats.If you are not a vegetarian, substitute fatty fish (salmon, mackerel,tuna) instead of meats high insaturated fat.Incorporate foods high in polyunsaturated and monounsaturated fats like avocados, nuts, and oliveoil

FATOVERCONSUMPTION

YOU:

30NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Fat Overconsumption by checking out the following articles:

Fats and Cholesterol

GENETICVARIATIONS



rs13290799, rs12327666



https://fnic.nal.usda.gov/food-composition/macronutrients/fats-and-cholesterol




SUMMARY

Your joint injury potential is within the typical range.However it is wise to reduce the risk of joint injury by taking simple steps.

Avoid doing too much, too soon. Never increase the length of your workouts by more than10 percent from one week to the next, and never increase both the length and intensity ofyour workout at the same time.Maintain strength in the muscles surrounding the joint area. To strengthen the knees, do calfraises, lunges, squats, and leg lifts. For the shoulders, do simple moves such as push-ups,lateral lifts with light weights, and bench dips.Train smart by cross-training. Repetitive-motion injuries caused by doing just one sport orworkout are some of the most common. You can prevent them by doing different sports oractivities that work different muscles. For example, if you mostly ride a bike, take a core-strengthening class once a week.

As always consult with a fitness professional on how to best strengthen your joints.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Joint Injury Risk3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISJOINTINJURYRISK

Many sports-related injuries involve damage to the joints. Common joint injuries include a twisted ankle,sprained wrist, overextended elbow, and damaged knee ligaments. When exercising you can be more at riskfor overuse injuries. But you can build strength in your joints and avoid joint injuries by stretching andexercising correctly.

The risk of joint injury is associated with higher genetic predisposition to osteoarthritis. Knowing about thisrisk is important in adjusting duration and intensity of training sessions. Sports and high-impact activitieslead to cartilage lesions, and may lead to joint injuries. Your risk for the joint injury is computed based on 13genetic variations that were found to be associated with joint problems.

JOINTINJURYRISK

YOU:

10NORMAL


WHATTODO

Your joint injury potential is within the typical range.However it is wise to reduce the risk of joint injury by taking simple steps. Avoid doing too much, too soon. Never increase the length of your workouts by more than 10percent from one week to the next, and never increase both the length and intensity of your workoutat the same time.

Maintain strength in the muscles surrounding the joint area. To strengthen the knees, do calfraises, lunges, squats, and leg lifts. For the shoulders, do simple moves such as push-ups,lateral lifts with light weights, and bench dips.Train smart by cross-training. Repetitive-motion injuries caused by doing just one sport orworkout are some of the most common. You can prevent them by doing different sports oractivities that work different muscles. For example, if you mostly ride a bike, take a core-strengthening class once a week.Never skip your warm-up or cool down. Tight or stiff muscles around a joint will make thearea more prone to injury. This is especially important in sports that require quickmovements, such as basketball and tennis.Always use proper technique and body mechanics when playing sports involving repetitivemotion, such as tennis and golf.


NATUREVS.NURTURE


GENETICVARIATIONS



rs16944, rs8044769, rs5009270







SUMMARY

Given you do seem to have a slight genetic advantage for leaner body mass, you can maximize yourmuscle content by engaging in more power exercises.You can calculate your leanbodymassusingthiscalculator(thirdparty).The closer your weight is to your actual lean body mass while building muscles, the fitter you are.

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for Lean BodyMass Potential4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 50% of the population and is consideredstatistically advantaged compared to the general population.

WHATISLEANBODYMASSPOTENTIAL

Your lean body mass is the portion of your weight that is not fat. Your lean body mass is actually composedof your muscle and bone tissue as well as the water in your body and your organs – everything except the fatbeneath the surface of your skin. Leaner body mass has a strong genetic component. If you are predisposedto having a higher lean body mass, you have a better chance of attaining a muscular body through fitnessexercises than the average population. Higher lean body mass also decreases the likelihood of excessivebody weight, obesity, impaired protein balance, osteoporosis and sarcopenia.

LEANBODYMASSPOTENTIAL

YOU:

50ADVANTAGED


WHATTODO

Given you do seem to have a slight genetic advantage for leaner body mass, you can maximize your musclecontent by engaging in more power exercises.

You can calculate your leanbodymassusingthiscalculator(thirdparty).The closer your weight is to your actual lean body mass while building muscles, the fitter you are. To build a leaner body, try the following tips: Consume a high-protein meal in the early evening

Use a combination of heavier weights with few repetitions or if that is strenuous use lighterweights with higher repetitions. In all cases consult with your trainer. Try short, high-intensity cardio workouts.Make sure you are getting enough Vitamin D, particularly if your Silverberry Vitamin D reportindicates a slightly elevated or elevated likelihood of Vitamin D inadequacy.

Please make sure to explore your other fitness characteristics to avoid any injury or cardiac stresspotential when selecting a proper exercise routine.If you wish to attain a higher lean body mass through rigorous exercise, you may want to discussyour options with a fitness professional.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1056513, rs2276541, rs12439003


rs6544334






SUMMARY

You do not have any known predispositions that would indicate an impulse for lower protein intake.You should be fine consuming proteins up to the levels prescribed by the FDA for the averagepopulation.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Low Protein Intake Risk5 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 55% of the population and is consideredstatistically low compared to the general population.

WHATISLOWPROTEININTAKERISK

Protein is the major structural component of all cells in the body, and functions as enzymes, transportcarriers and as some hormones. Large study identified genetic predispositions associated with proteinintake. Some genetic variations are associated with a tendency for lower protein intake, while others arefound to be associated with higher consumption of protein.

WHATTODO


NATUREVS.NURTURE


LOWPROTEININTAKERISK

YOU:

55NORMAL


LEARNMORE

Learn more about Low Protein Intake Risk by checking out the following articles:

Protein and Amino Acids

GENETICVARIATIONS



rs838133, rs1350036, rs9553939


rs9939609, rs1421085

https://fnic.nal.usda.gov/food-composition/macronutrients/protein-and-amino-acids







SUMMARY

Given your "normal/fast" resting metabolic rate (RMR) you should be able to burn your caloriesefficiently, provided you are on a healthy diet and do not have issues with fat or carb processing.Calculate your RMRusingthiscalculator.As the RMR tends to decrease with age, most people need to monitor their calorie intake andincorporate physical activities in their daily lives to maintain healthy energy balance.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Low Resting Metabolic Rate5 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 65% of the population and is consideredstatistically low compared to the general population.

WHATISLOWRESTINGMETABOLICRATE

Body weight depends on the balance between energy intake and energy expenditure. Energy intake comesfrom calories consumed, and energy expenditure is the energy that body uses to maintain normal bodytemperature and essential processes such as metabolism, breathing, brain functioning. Individual differencesin the energy cost of self-maintenance (resting metabolic rate, RMR) are substantial, and depend on age,weight, environment, and genetics. The heritability of RMR is 40-50% of the variance remaining afteradjustment for age, gender, and fat-free mass. Uncoupling proteins, UCP1 and UCP3, play important roles inregulating body temperature and energy expenditure: these proteins are found in brown fats and they areinvolved in metabolic process by which energy is dissipated as heat in response to excess of caloric intakeand cold stress. People with genetic variations in the UCP genes tend to have lower RMR.

WHATTODO

Given your "normal/fast" resting metabolic rate (RMR) you should be able to burn your calories efficiently,provided you are on a healthy diet and do not have issues with fat or carb processing.

Calculate your RMRusingthiscalculator.As the RMR tends to decrease with age, most people need to monitor their calorie intake andincorporate physical activities in their daily lives to maintain healthy energy balance.To ensure you are eating the right kind of foods, check your Nutrition report to see if you have carbor fat processing predispositions.

LOWRESTINGMETABOLICRATE

YOU:

65NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs1011397, rs3811787, rs6818288, rs1549059, rs2075577









SUMMARY

You do not have any known predispositions that would indicate an impulse for lower vegetableintake.You should be fine consuming vegetables as prescribed by the FDA for the average population.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Low Vegetable IntakeNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISLOWVEGETABLEINTAKE

It is a well-known fact that consumption of fruits and vegetables adds important under-consumed nutrientsto diets. Fruits and vegetables reduce the risk of heart disease, stroke, and some cancers, and help manageweight. Most U.S. residents consume too few fruits and vegetables. It is important to ensure you haveadequate amounts of fruits and vegetables in your diet.

WHATTODO

You do not have any known predispositions that would indicate an impulse for lower vegetable intake.You should be fine consuming vegetables as prescribed by the FDA for the average population.

NATUREVS.NURTURE


LOWVEGETABLEINTAKE

YOU:

30NORMAL


LEARNMORE

Learn more about Low Vegetable Intake by checking out the following articles:

Fruits & Veggies-More Matter

GENETICVARIATIONS






http://fnic.nal.usda.gov/dietary-guidance/fruits-veggies-more-matters-resources/fruits-veggies-more-matters


SUMMARY

A low-carb diet is more likely to be effective for you than individuals who do not have predispositionto carb-sensitivity. Limit your daily carb intake to less than 40% of total calories consumed. To monitor the actualusage, there are many tools that allow you to enter daily foods and see your nutritional intake. Onesuch tool is MyFitnessPalYou can find more than100low-carbdietrecipesbyclickinghere(this will take you to a thirdparty site).

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for Low-carb DietEffectiveness7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 75% of the population and is consideredstatistically advantaged compared to the general population.

WHATISLOW-CARBDIETEFFECTIVENESS

Carbohydrates are the main fuel source, and they provide vitamins, minerals, antioxidants and fiber in thediet. While your body uses carbohydrates as its main fuel source, there are substantial health benefits tolimiting your carbohydrate intake. There are two major types of carbohydrates, simple (bad) and complex(good). Simple carbohydrates include sugary foods, pasta, bread, and white rice. Complex carbohydratesare whole grains, and legumes, including brown rice, and whole wheat breads. It is beneficial to eat morecomplex carbohydrates. People with genetic variations in several genes associated with obesity, insulinsensitivity, and high levels of bad cholesterol (LDL) are more sensitive to carbohydrates in their diet. Thesepeople may benefit more from low carbohydrate diet that reduces the amount of calories from carbohydratesand consuming nearly equal proportions of fats and proteins. A low-carb diet restricts the type and amountof carbohydrates you eat. In general, a low-carb diet focuses on proteins, including meat, poultry, fish andeggs, and some nonstarchy vegetables. A low-carb diet generally excludes or limits most grains, legumes,fruits, breads, sweets, pastas and starchy vegetables, and sometimes nuts and seeds.

LOW-CARBDIETEFFECTIVENESS

YOU:

75ADVANTAGED

https://www.myfitnesspal.com/

https://authoritynutrition.com/101-healthy-low-carb-recipes/


WHATTODO

A low-carb diet is more likely to be effective for you than individuals who do not have predisposition to carb-sensitivity.

Limit your daily carb intake to less than 40% of total calories consumed. To monitor the actualusage, there are many tools that allow you to enter daily foods and see your nutritional intake. Onesuch tool is MyFitnessPalYou can find more than100low-carbdietrecipesbyclickinghere(this will take you to a thirdparty site). For the carbs you do consume, try to eat more complex carbohydrates such as whole grains, andlegumes, including brown rice, and whole wheat breads.Low-carb diets may help prevent or improve serious health conditions, such as metabolic syndrome,diabetes, high blood pressure and cardiovascular disease. (Mayo Clinic)Choosing a low-carb diet may improve blood cholesterol or blood sugar levels, at least temporarily(Mayo Clinic)It is not recommended that you reduce your carb in-take to less than 60 grams per day of carbs. Ifyou suddenly and drastically cut carbs, you may experience a variety of temporary health effects,including headache, bad breath, weakness, fatigue, constipation, or diarrhea.

NATUREVS.NURTURE


LEARNMORE

Learn more about Low-carb Diet Effectiveness by checking out the following articles:

A Complete Guide to Complex Carbohydrates Low-carb diet: Can it help you lose weight?



http://www.livestrong.com/article/27398-list-complex-carbohydrates-foods/

http://www.mayoclinic.org/healthy-lifestyle/weight-loss/in-depth/low-carb-diet/art-20045831


GENETICVARIATIONS



rs10850219, rs1042714, rs2306179, rs2241201, rs5883, rs7957619, rs3764261











SUMMARY

Your genetic predisposition score would indicate a slightly higher effectiveness of low-fat diet forweight loss and healthy weight maintenance,To try a low-fat diet, reduce your fat intake to less than 20% and increase your protein and complexcarbs intake. It is important to include polyunsaturated and monounsaturated (good) fats in your diet. Good fatsare contained in fish, olive oils, avocados, and nuts.

MYASSESMENT

Good News! You seem to have some advantageous genetic predispositions for Low-fat DietEffectiveness8 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically advantaged compared to the general population.

WHATISLOW-FATDIETEFFECTIVENESS

General recommendation is to limit fat intake to 35% of total calories and to control saturated fat intake. Alow-fat diet restricts fat intake to 20%, while increases protein and complex carbohydrate intake. Monitoringsaturated fats is particularly important: at least 12% of daily calories should come from poly- andmonounsaturated fats. The other 80% of calories in the diet come from carbohydrates and protein withgeneral recommendations to consume about 55-60% of carbs and 20-25% of proteins. Low fat high proteindiet is based on boosting protein intake to 40%, while decreasing carbohydrate intake to 40%. Numerouslarge-scale studies on weight loss found that people with variations in genes associated with sensitivity to fat(such as FTO, PPARG, APOA2, LIPC) are more responsive to low fat diets if their goal is weight loss.

LOW-FATDIETEFFECTIVENESS

YOU:

65SLIGHTLY

ADVANTAGED


WHATTODO

Your genetic predisposition score would indicate a slightly higher effectiveness of low-fat diet for weight lossand healthy weight maintenance,

To try a low-fat diet, reduce your fat intake to less than 20% and increase your protein and complexcarbs intake. It is important to include polyunsaturated and monounsaturated (good) fats in your diet. Good fatsare contained in fish, olive oils, avocados, and nuts.Try the following low-fat recipes from Mayo Clinic (with 3 grams of fat or less per serving) to achievea healthy weight loss. Mayo Clinic Low-fat Foods

NATUREVS.NURTURE


LEARNMORE

Learn more about Low-fat Diet Effectiveness by checking out the following articles:

Low-Fat Diets for Weight Loss Low-fat Diet HEART UK's Low Fat Eating Plan

GENETICVARIATIONS



rs2943641, rs9939609, rs7903146, rs1801282, rs1440581, rs8050136, rs1558902, rs1799883



http://www.mayoclinic.org/healthy-lifestyle/recipes/low-fat-recipes/rcs-20077196

http://www.webmd.com/women/reducing-dietary-fat

https://en.wikipedia.org/wiki/Low-fat_diet

https://heartuk.org.uk/cholesterol-and-diet/low-fat-eating-plan/meal-plan










SUMMARY

If your goal is weight loss and you are considering which diet to choose, the healthy Mediterraneandiet full of good fats is likely to be the right choice for you.To leverage your advantaged predisposition for the Mediterranean diet, you can increase your intakeof olive oil and nuts that are important in reducing risks of heart disease, increase good cholesterol,and are associated with longevity.Overall, Mediterranean diet is based on consuming 35% of daily calories from fats, including up to22% from monounsaturated fats, 20% of good quality proteins from fish and meats, and up to 40%of carbohydrates.

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for MediterraneanDiet Effectiveness3 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically advantaged compared to the general population.

WHATISMEDITERRANEANDIETEFFECTIVENESS

Mediterranean diet is known to have many health benefits. It is rich in monounsaturated (good) fats that areimportant in reducing risks of heart disease, increasing good cholesterol, delaying cognitive decline. It is alsoassociated with longevity. Research by Mayo Clinic has shown that the traditional Mediterranean dietreduces the risk of heart disease. The diet has been associated with a lower level of oxidized low-densitylipoprotein (LDL) cholesterol — the "bad" cholesterol that's more likely to build up deposits in your arteries.According to the Mayo Clinic, a meta-analysis of more than 1.5 million healthy adults demonstrated thatfollowing a Mediterranean diet was associated with a reduced risk of cardiovascular mortality as well asoverall mortality. The Mediterranean diet is also associated with a reduced incidence of cancer, andParkinson's and Alzheimer's diseases. Women who eat a Mediterranean diet supplemented with extra-virginolive oil and mixed nuts may have a reduced risk of breast cancer (Mayo Clinic).

In people with genetic variations in the ADIPOQ, gene and Mediterranean diet also helps to facilitate fat lossand to improve metabolic health. Genetic variations in several other genes, including PPARG, MTHFR,TCF7L2, LPL and MLXIPL, were found to be associated with increased advantage of following theMediterranean diets.

MEDITERRANEANDIETEFFECTIVENESS

YOU:

85ADVANTAGED

http://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/mediterranean-diet/art-20047801


WHATTODO

If your goal is weight loss and you are considering which diet to choose, the healthy Mediterranean diet fullof good fats is likely to be the right choice for you.

To leverage your advantaged predisposition for the Mediterranean diet, you can increase your intakeof olive oil and nuts that are important in reducing risks of heart disease, increase good cholesterol,and are associated with longevity.Overall, Mediterranean diet is based on consuming 35% of daily calories from fats, including up to22% from monounsaturated fats, 20% of good quality proteins from fish and meats, and up to 40%of carbohydrates.Check out the Mediterranean diet recipes of Mayo Clinic for inspriation.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1801133, rs13702, rs17300539



http://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/mediterranean-diet-recipes/art-20046682





SUMMARY

You do not seem to have genetic predispositions that were found to be associated with increased episodicmemory performance. Your genetic-influenced memory performance falls within the average range of thepopulation. Still, it is never too late to start training your memory.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Memory Performance1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISMEMORYPERFORMANCE

Human memory is the result of many distinct mental processes, such as memory encoding, forgetting, andmodulation of memory strength by various stimuli. Memory has large inter-individual variability andsubstantial heritability. It depends on many genetic factors (it is a polygenic trait) and only a few of them havebeen characterized so far. We test 3 genetic variations that account for episodic memory (ability to recallwords and pictures) that have recently been identified. Genetic variation in the BAIAP2 gene is related tonegative emotional modulation of human memory strength. People who carry the minor A allele of rs8067235variant performed significantly better in recalling negative images compared to neutral pictures, while carriersof the major allele did not demonstrate any difference. Carriers of KIBRA rs17070145 T allele had 25% betterfree recall performance 5 min after word presentation and 20% better free recall performance 24 hours afterword presentation than did non-carriers.

WHATTODO


MEMORYPERFORMANCE

YOU:

5TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Memory Performance by checking out the following articles:

Gene Variation Affects Memory

GENETICVARIATIONS



rs17070145



http://www.genomenewsnetwork.org/articles/08_03/memory.shtml



SUMMARY

Never heard of this condition? You are not alone! Misophonia can be a real problem. If you meedsomeone with Misophonia, appreciate that it is a real conditionIn a new study, The Brain Basis for Misophonia, brain imaging has demonstrated that people withMisophonia have an abnormality in the emotional control mechanism which causes their brains to gointo overdrive on hearing the trigger soundsIf you think you friend, or yourself, have Misophonia symptoms, understand that this is a realcondition and look up www.misophonia.com to seek support

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for MisophoniaNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically low compared to the general population.

WHATISMISOPHONIA

Misophonia is a sensitivity to chewing sounds (from the Greek meaning hatred of sound). It is a newlyrecognized condition that is characterized by feelings of rage triggered by small sounds: people munching,gum chewing, sipping, footsteps, humming, which are called `trigger sounds` misophonia community. Theresponse can be an immediate and intense fight or flight feeling that creates panic and rage, and suffererscan become violent and emotionally explosive. Misophonia usually starts at late childhood. People who self-reported themselves as being sensitive to noise, frequently have a genetic variation in the gene TENM2 thatplays a role in brain development.

WHATTODO

Never heard of this condition? You are not alone! Misophonia can be a real problem. If you meed someonewith Misophonia, appreciate that it is a real condition

In a new study, The Brain Basis for Misophonia, brain imaging has demonstrated that people withMisophonia have an abnormality in the emotional control mechanism which causes their brains to gointo overdrive on hearing the trigger soundsIf you think you friend, or yourself, have Misophonia symptoms, understand that this is a realcondition and look up www.misophonia.com to seek support

MISOPHONIA

YOU:

5NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY

In addition to genetics, other factors contribute to motion sickness including travel anxiety andgeneral stress, headaches, intoxication, dehydrationIf you are traveling by car, risk factors include poor ventilation and sitting in the back seat or whereyou cannot see out the windowFor women, pregnancy or having a period are risk factors

MYASSESMENT

You seem to have elevated genetic predispositions risk for Motion Sickness17 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 90% of the population and is consideredstatistically risky compared to the general population.

WHATISMOTIONSICKNESS

Motion sickness (sometimes referred to as travel sickness) is a common condition that occurs in somepeople who travel by car, train, airplane or boat. Motion sickness is a general term, and the symptomsinclude nausea, dizziness, and fatigue. Roughly one in three individuals is susceptible to motion sickness,and almost two thirds report being sick in more sever conditions. About 7% of seagoing passengers reportvomiting during the journey. Charles Darwin once wrote to his father: "The misery I endured from sea-sickness is far far beyond what I ever guessed at. If it was not for sea-sickness, the whole world would besailors." Children, and older people are more susceptible to motion sickness, and women generally reportmore cases of motion sickness than men. Motion sickness happens when the body, the inner ear, and theeyes send conflicting signals to the brain. The first study on over 80 thousands individuals yielded geneticvariants associated with motion sickness. The study reports that several genetic variants show up to threetimes stronger effects in women. Some genetic variations increase the likelihood of motion sickness, whileother variants are protective. Interestingly, occurrences of motion sickness correlate with migraines, altitudesickness, morning sickness, postoperative nausea and vomiting, and poor sleeping.

MOTIONSICKNESS

YOU:

90ELEVATED


WHATTODO

In addition to genetics, other factors contribute to motion sickness including travel anxiety and generalstress, headaches, intoxication, dehydration

If you are traveling by car, risk factors include poor ventilation and sitting in the back seat or whereyou cannot see out the windowFor women, pregnancy or having a period are risk factorsIf you suffer from motion sickness, sit in the front in a car, keep your eyes on the horizon, or driveAvoid big fatty meals before your travel; avoid salty foods and alcoholFresh air helps: open windows in the car or move to the top deck of a shipIf you want to take medication to treat your motion sickness, take it before your journey to preventsymptoms developing. Discuss side effects with your pharmacist.

NATUREVS.NURTURE


LEARNMORE

Learn more about Motion Sickness by checking out the following articles:

The Mysterious Science of Motion Sickness Motion Sickness - Topic Overview

GENETICVARIATIONS



rs11129078, rs2318131, rs60464047, rs10752212, rs1782032, rs6946969, rs1858111, rs4343996,rs705145, rs1847202, rs17515225, rs2153535, rs7170668, rs6069325, rs4076764, rs2360806,rs66800491



http://www.theatlantic.com/health/archive/2015/02/the-mysterious-science-of-motion-sickness/385469/

http://www.webmd.com/cold-and-flu/ear-infection/tc/motion-sickness-topic-overview



















SUMMARY

While you may not have known genetic risks for muscle damage, to minimize the risk of a potentialmuscle tear, there are many steps you can take.For one, try not to sit in one position for too long and move about when working long hours in theoffice.Always stretch and warm up before and after engaging in exercise.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Muscle Damage Risk1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISMUSCLEDAMAGERISK

A muscle strain, or pulled muscle, occurs when your muscle is overstretched or torn. This usually occurs asa result of fatigue, overuse, or improper use of a muscle. Strains can happen in any muscle, but they’re mostcommon in your lower back, neck, shoulder, and hamstring, which is the muscle behind your thigh. Muscledamage can be caused by different reasons, including increased lactate oxidation, deficient lactate effluxpathways, or release of intracellular muscle components into the bloodstream. Mutations in some genes inthese pathways are associated with rare condition known as cryptic exercise intolerance. Common geneticvariation in the same genes have been found to be associated increased risk of muscle injury, musclecramping, and lactate accumulation in the muscle. This genetic variation has been associated withincidences of muscle injuries in elite football players. A predisposition to increased muscle damage risk canmean that you have to be more careful about lifting heavy weights or making sudden moves than theaverage person. Additionally, you may want to focus your exercises on those that improve the tenacity andflexibility of your muscles.

MUSCLEDAMAGERISK

YOU:

10NORMAL


WHATTODO

While you may not have known genetic risks for muscle damage, to minimize the risk of a potential muscletear, there are many steps you can take.

For one, try not to sit in one position for too long and move about when working long hours in theoffice.Always stretch and warm up before and after engaging in exercise.We are in a culture where pushing your limits is seen as a virtue, but it is good to be aware of thelimitations of one's body.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1860189





SUMMARY

You do not have an elevated predisposition likelihood for muscle response to resistance training. Thisimplies that you are likely to see more graduate gains in your muscle size and strengthening. According toMayo clinic, resistance and weight training is an important part of any fitness program. Combined withaerobic exercise, weight training can increase your strength and muscle tone, improve your bone densityand help you lose weight.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Muscle Response ToResistance Training4 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISMUSCLERESPONSETORESISTANCETRAINING

Muscle-strengthening are recommended to be included in fitness routines for a minimum of 2 days a week.Long-term systematic resistance training increases skeletal muscle size and strength in both men andwomen of different ages. While studies demonstrate that nearly all individuals will get some benefit from RT,RT-induced gains in muscle size and strength are highly variable between individuals. Muscle strength andsize gains following standardized program depend on gender, age, general health, nutrition, and genetics.Several studies reported associations with muscle strength and size. People with some genetic variationsgained higher (isometric) muscle strength and biceps size in response to the same resistance trainingroutine.

WHATTODO


MUSCLERESPONSETORESISTANCETRAINING

YOU:

25TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Muscle Response To Resistance Training by checking out the following articles:

Slide show: Weight Training Exercises

GENETICVARIATIONS



rs2296135, rs1805086, rs1137101


rs4634384

http://www.mayoclinic.org/healthy-lifestyle/fitness/multimedia/weight-training/sls-20076904






SUMMARY

You may experience more pronounced muscle soreness after exercise than the avergae population. Drinking coffee before exercise, having a protein shake, eating a low-fat, high-carb and high proteinnutrition bar, an adequate warm-up routine and staying hydrated are key to preventing musclesoreness.Additionally, electrolyte-rich foods like bananas or avocados are quite helpful in keeping the rightmineral balance within your muscles. Right before finishing your exercise routine, include 10 or sominutes of "easy aerobic work such as jogging or walking followed by stretching.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Muscle Soreness5 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISMUSCLESORENESS

The delayed onset muscle soreness refers to the feeling of soreness 12-24 hours after heavy exercise. It iscommonly understood to be the result of microscopic tears in your muscle tissue. The mild muscle straininjury creates microscopic damage to the muscle fibers and coupled with the resulting inflammation causesthe pain. The less fit you are, the more likely it is for your muscles to feel sore.

If you have a higher predisposition towards muscle soreness, you may want to only gradually increase theintensity of your workouts and concentrate more on endurance exercises that put less pointed pressure onyour muscles. Genetic variants in some inflammation-related genes (IGF2) were found to be related to thegreatest muscle soreness immediately after exercise, and highest post-exercise serum creatine kinaseactivity.

MUSCLESORENESS

YOU:

95ELEVATED


WHATTODO

You may experience more pronounced muscle soreness after exercise than the avergae population. Drinking coffee before exercise, having a protein shake, eating a low-fat, high-carb and high proteinnutrition bar, an adequate warm-up routine and staying hydrated are key to preventing musclesoreness.Additionally, electrolyte-rich foods like bananas or avocados are quite helpful in keeping the rightmineral balance within your muscles. Right before finishing your exercise routine, include 10 or sominutes of "easy aerobic work such as jogging or walking followed by stretching.Taking a cold shower after your exercise also minimizes the chance of inflammation.

NATUREVS.NURTURE


GENETICVARIATIONS



rs13266634, rs1799865, rs680, rs3213221, rs7924316









SUMMARY

Your genetic muscle loss risk is high and you may consider slowing it down by adequate proteinintake, sufficient calorie intake, and regular exercise. Try to include creatine, vitamin D, and whey protein within your diet. The primary method of slowing down muscle strength loss is resistance training or strength training.These activities increase muscle strength and endurance using weights or resistance bands.Resistance training can help your neuromuscular system, hormones.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Muscle Strength Loss4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISMUSCLESTRENGTHLOSS

From the time you are born to around the time you turn 30, your muscles grow larger and stronger. But atsome point in your 30s, you start to lose muscle mass and function. The cause is age-related sarcopenia.Physically inactive people can lose as much as 3% to 5% of their muscle mass each decade after age 30.Even if you are active, you’ll still have some muscle loss.

The speed by which we lose muscle strength when we stop exercising, depends on a variety of factors, suchas age, diet and the amount of sleep that we get. Sometimes even two weeks of physical inactivity can resultin substantial muscle strength loss. Genetic variants in some inflammation-related genes (IGF2) were foundto be related to the greatest muscle strength loss after exercise.

MUSCLESTRENGTHLOSS

YOU:

95ELEVATED


WHATTODO

Your genetic muscle loss risk is high and you may consider slowing it down by adequate protein intake,sufficient calorie intake, and regular exercise.

Try to include creatine, vitamin D, and whey protein within your diet. The primary method of slowing down muscle strength loss is resistance training or strength training.These activities increase muscle strength and endurance using weights or resistance bands.Resistance training can help your neuromuscular system, hormones. Some exercises that will help you slow down muscle loss include:Pull-down (or alternatively chin-up)

Chest pressCompound row (A pulling motion in the horizontal plane)Overhead pressLeg press

The proper number, intensity, and frequency of resistance exercise is important for getting the mostbenefit with the least risk of injury. You should work with an experienced physical therapist or trainerto develop an exercise plan.

NATUREVS.NURTURE


LEARNMORE

Learn more about Muscle Strength Loss by checking out the following articles:

Muscle Strength Fades After Just Two Weeks of Inactivity

http://www.webmd.com/fitness-exercise/news/20150708/muscle-strength-fades-after-just-two-weeks-of-inactivity#1


GENETICVARIATIONS



rs3213221, rs680, rs13266634, rs7924316








SUMMARY

There is a strong connection between noise and hearing loss. While you do not have geneticpredisposition to noise induced hearing loss, loud sounds are damaging to your hearingNoise is measured in decibels (dB): the higher the number, the louder the noise and the moredamage it can inflict on your hearing, in particular if it is prolonged. Noise levels above 105dB candamage your hearing if you listen to it for 15-20 minutes each week. A normal conversation is 60-65dB, lawn mower and heavy traffic is 85dB, while MP3 player on loud is 110dB, and rock concert is120dBTo protect your hearing, reduce the volume when listening to music, TV, radio; use earplugs at livemusic concerts; wear ear protectors when you are using lawn mowers or noisy equipment; do notlisten to music too loud and too long when driving

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Noise-induced Hearing Loss2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically low compared to the general population.

WHATISNOISE-INDUCEDHEARINGLOSS

Noise induced hearing loss is a temporary or permanent hearing impairment resulting from prolongedexposure to high levels of noise. Excessive noise exposure is the most common cause of hearing loss. Inmodern society we are constantly bombarded by noises, on our headphones, TVs, or in the cities. Whenthese sounds are at safe level they do not damage our hearing. But too loud sounds can damage inner earand cause noise-induced hearing loss (NIHL). Noise is probably the most common occupational hazardfacing people today. According to the National Institute on Deafness, "people of all ages, including children,teens, young adults, and older people, can develop NIHL. Approximately 15 percent of Americans betweenthe ages of 20 and 69—or 26 million Americans—have hearing loss that may have been caused by exposureto noise at work or in leisure activities. As many as 16 percent of teens (ages 12 to 19) have reported somehearing loss that could have been caused by loud noise". While too loud noises are not good for anyone,studies identified genetic variations associated with increased risk of NIHL.

NOISE-INDUCEDHEARINGLOSS

YOU:

5NORMAL


WHATTODO

There is a strong connection between noise and hearing loss. While you do not have genetic predispositionto noise induced hearing loss, loud sounds are damaging to your hearing

Noise is measured in decibels (dB): the higher the number, the louder the noise and the moredamage it can inflict on your hearing, in particular if it is prolonged. Noise levels above 105dB candamage your hearing if you listen to it for 15-20 minutes each week. A normal conversation is 60-65dB, lawn mower and heavy traffic is 85dB, while MP3 player on loud is 110dB, and rock concert is120dBTo protect your hearing, reduce the volume when listening to music, TV, radio; use earplugs at livemusic concerts; wear ear protectors when you are using lawn mowers or noisy equipment; do notlisten to music too loud and too long when drivingHave a hearing detox and introduce quiet periods during the day.

NATUREVS.NURTURE


LEARNMORE

Learn more about Noise-induced Hearing Loss by checking out the following articles:

Top 10 tips to help protect your hearing Noise-Induced Hearing Loss

GENETICVARIATIONS



rs7429015


rs2227578

http://www.nhs.uk/Livewell/hearing-problems/Pages/tips-to-protect-hearing.aspx

https://www.nidcd.nih.gov/health/noise-induced-hearing-loss




SUMMARY

You may not see quick benefits from moderate exercise on your health, in particular if you haveissues with cholesterol, triglycerides, and hypertension.You may need to boost your exercise frequency and perhaps intensity in combination to a healthydiet to see a significant impact on your cholesterol, triglycerides, and blood pressure levels. Regular exercise of at least 45 minutes per day, together with a healthy diet, will most likely result inimproved vitals over time.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Overall Fitness Benefits1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISOVERALLFITNESSBENEFITS

The health benefits of regular exercise and physical activity are hard to ignore. Everyone benefits fromexercise, regardless of age, sex or physical ability. Exercise can help prevent excess weight gain or helpmaintain weight loss. Regular exercise helps prevent or manage a wide range of health problems andconcerns, including stroke, metabolic syndrome, type 2 diabetes, depression, a number of types of cancer,arthritis and falls. Exercise delivers oxygen and nutrients to your tissues and helps your cardiovascularsystem work more efficiently. And when your heart and lung health improve, you have more energy to tackledaily chores.

Some people show quick and strong benefits, while others need more exercise and changes to their dietstoo. For people with some genetic variants, active life-style was shown to produce quick results to lowerlevels of cholesterol, triglycerides, and blood pressure.

OVERALLFITNESSBENEFITS

YOU:

5TYPICAL


WHATTODO

You may not see quick benefits from moderate exercise on your health, in particular if you have issues withcholesterol, triglycerides, and hypertension.

You may need to boost your exercise frequency and perhaps intensity in combination to a healthydiet to see a significant impact on your cholesterol, triglycerides, and blood pressure levels. Regular exercise of at least 45 minutes per day, together with a healthy diet, will most likely result inimproved vitals over time. Exercises that are useful for your overall health include: Brisk walking , Cycling, Swimming, Dancing,Mowing the lawn, Tennis and Jogging.Always consult with your physician before changing the intensity and frequency of your workouts.

NATUREVS.NURTURE


GENETICVARIATIONS



rs62205366





SUMMARY

Your risk for overall tendon or ligament injury are within the typical range of the population. You maystill have more specific risks associated with Achilles tendons or ACL, so do check those traits. To reduce your chance of getting tendon injuriy we recommend to include stretching to increaseflexibility, plus eccentric strengthening of the gastrocnemius and soleus muscles.We recommend gastrocnemius/soleus eccentric strengthening, calf and Achilles stretches.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Overall Tendon And LigamentInjury Risk7 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISOVERALLTENDONANDLIGAMENTINJURYRISK

Non-contact tendon or ligament injury is an overuse injury associated with sports, and are a common causeof disability. Most major tendons, such as the Achilles, patellar, rotator cuff and forearm extensor tendons(amongst others) are vulnerable to overuse, which induces pathological changes in the tendon. Knowingyour genetic susceptibility to specific injury will help in customization of exercise recommendations,choosing the right prevention strategies like avoidance of weight-bearing and high-impact sports forindividuals who have risk profile genotypes would take advantage of this information.

WHATTODO

Your risk for overall tendon or ligament injury are within the typical range of the population. You may stillhave more specific risks associated with Achilles tendons or ACL, so do check those traits.

To reduce your chance of getting tendon injuriy we recommend to include stretching to increaseflexibility, plus eccentric strengthening of the gastrocnemius and soleus muscles.We recommend gastrocnemius/soleus eccentric strengthening, calf and Achilles stretches.It is also recommended to shift to running on softer surfaces.As always, consult with a personal trainer before making any changes to your routines.

OVERALLTENDONANDLIGAMENTINJURYRISK

YOU:

10NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs495366, rs2104772


rs970547, rs1800012, rs679620, rs240736, rs591058









SUMMARY

You may be predisposed to excessive weight gain. Develop healthy eating habits, looking for ways to make favorite dishes healthier, and reducingcalorie-rich temptations.Another part of balancing calories is to engage in an appropriate amount of physical activity andavoid too much sedentary time.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Overweight Potential7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISOVERWEIGHTPOTENTIAL

Multiple studies have demonstrated a significant role for genetics in overweight potential andobesity. Genetic variations influencing our propensity to gaining and keeping extra weight are notuncommon. The genes that were once beneficial to our ancestors during food shortages have becomeliabilities in today's environment of food excess. Some people have the tendency to gain weight through fatconsumption. Variants in the FTO, FABP2 and PPARG genes have been found to be associated with thisproblem. Variants in two lipolytic receptors in fat cells, ADRB2 and ADRB3, are found to be associated withhigh BMI and excessive weight gain due to high carb intake, in particular refined carbs. Genetic variants inMC4R gene are associated with increased frequency of snacking, and higher risk of diabetes. Whileoverweight related traits have a significant genetic component, diet, habits, and lifestyle play important rolestoo.

OVERWEIGHTPOTENTIAL

YOU:

95ELEVATED


WHATTODO

You may be predisposed to excessive weight gain. Develop healthy eating habits, looking for ways to make favorite dishes healthier, and reducingcalorie-rich temptations.Another part of balancing calories is to engage in an appropriate amount of physical activity andavoid too much sedentary time.Follow general recommendations to keep a balanced diet and maintain a healthy BMI (20-25)To assess your current BMI, use theMayoClinicBMICalculator

NATUREVS.NURTURE


LEARNMORE

Learn more about Overweight Potential by checking out the following articles:

Gens Linked to Obesity Hasn't Always Been a Problem, Study Finds Adult Obesity Facts

GENETICVARIATIONS



rs9939609, rs1042714, rs1421085, rs17782313, rs1801282, rs12970134, rs10830963



http://www.mayoclinic.org/diseases-conditions/obesity/in-depth/bmi-calculator/itt-20084938

http://www.nytimes.com/2015/01/01/science/gene-linked-to-obesity-hasnt-always-been-a-problem-study-finds.html

http://www.cdc.gov/obesity/data/adult.html









SUMMARY

1 Follow general recommendations appropriate for your skin to minimize damage due to UV exposure

2 Chose your sunscreen carefully

3 Use sunscreen with SPF20 or higher

4 Check your sun sensitivity and pigmented spots reports

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Photoaging5 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 35% of the population and is consideredstatistically low compared to the general population.

WHATISPHOTOAGING

Skin photoaging is defined as premature aging of the skin due to sun exposure. It is among the most widelyappreciated harmful effects of chronic exposure to solar UV radiation. UV radiation causes DNA damage,oxidative stress, and disrupts normal architecture of skin connective tissue that impair skin function. Whileeveryone is experiencing skin photoaging, numerous data suggest that extrinsic skin aging parameters havea strong genetic basis. Large studies have identified genetic variations in STXBP5L and FBXO40 genesassociated with overall photoaging global scale score that combines pigmentation irregularities, sagging,and wrinkles. The analysis controlled for age, smoking history, hormonal status, body-mass index, hair colorat age 20, and other factors, and included estimation of lifetime sun exposure and intensity. A recent studyfound that the MC1R gene, that is responsible for pale skin and red hair, is also linked to increased aging.Interestingly, scientists discovered that associations between genetic variants in the MC1R gene andperceived age held true even after adjusting for skin tone, and wrinkling.

PHOTOAGING

YOU:

35NORMAL


WHATTODO





NATUREVS.NURTURE


LEARNMORE

Learn more about Photoaging by checking out the following articles:

Protect Against Sun-Induced Skin Aging From The Inside Out Gene linked to youthful looks has been discovered, scientists claim Genetic Secrets to Youthful Looks Revealed

GENETICVARIATIONS



rs17740066, rs322458, rs470647, rs6782033, rs6775899



http://www.lifeextension.com/magazine/2014/7/protect-against-sun-induced-skin-aging-from-the-inside-out/page-01

https://www.theguardian.com/science/2016/apr/28/gene-linked-to-youthful-looks-has-been-discovered-scientists-claim

https://www.scientificamerican.com/article/genetic-secrets-to-youthful-looks-revealed/







SUMMARY

While you may have an elevated resistance to novovirus, do follow general precautions in avoidingthe potentials of stomach fluWahs your hands! Using soap works much better than hand sanitizer, since the latter works mostlyfor bacteriaTry to avoid touching external surfaces such as in the subway or shopping carts

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for Resistance ToStomach Flu1 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically advantaged compared to the general population.

WHATISRESISTANCETOSTOMACHFLU

Stomach Flu, or Norovirus, is not really the flu but a viral gastroenteritis, and the major cause of foodborneillness worldwide, responsible for at least 50% of all gastroenteritis outbreaks in the United States. It iscaused by a nasty bug and it is very contagious and causes unpleasant symptoms that include abdominalpain, vomiting and diarrhea. It turns out that some people may be safer than most during the flu season.About 30 percent of people of European ancestry and 20 percent of people with African ancestry carry thespecific version of the genetic variation on the FUT2 (secretor) gene that prevents the most common strain ofNovovirus bug to enter their digestive tract. These lucky people are resistant to most common strain ofstomach flu. Whether you have a typical predisposition to being infected by this bug or have genetic-basedresistance, it is always a good idea to minimize the risks by following recommended procedures.

RESISTANCETOSTOMACHFLU

YOU:

85ADVANTAGED


WHATTODO

While you may have an elevated resistance to novovirus, do follow general precautions in avoiding thepotentials of stomach flu

Wahs your hands! Using soap works much better than hand sanitizer, since the latter works mostlyfor bacteriaTry to avoid touching external surfaces such as in the subway or shopping cartsWhen there is an epidemic of stomach flu in your neighborhood, eat at home. A study published inthe PLOS ONE found that restaurant dishes and silverware may be an overlooked place wherepeople can catch stomach viruses

NATUREVS.NURTURE


GENETICVARIATIONS



rs601338





SUMMARY

Wear sun-glasses and minimize sun exposureConsume vitamin-rich healthy diet Stay away from smoking

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Sagging Eyelids Risk2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISSAGGINGEYELIDSRISK

Sagging eyelids (hooded eyes or dermatochalasis) are a frequent concern in middle-aged and older adults. Ithappens due to a loss of elastic fibers and a disruption of the collagen network. Sagging eyelids are usuallya cosmetic concern, although they can cause visual field loss, ocular or eyelid irritation. They may also be acause of headaches due to forced brow elevation to increase the visual field. A recent large scale studyidentified nearly 30 genetic variations associated with sagging eyelids. These variations are located in 6different genetic regions that contain four genes TGIF1, SMYD3, ATP8A1, and PJA2. Interestingly, some ofthe identified genetic variations, including variation in the TGIF1 gene (an inducer of transforming growthfactor β) have protective effect, others are associated with increased incidents of sagging eyelids.

WHATTODO


SAGGINGEYELIDSRISK

YOU:

10NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs6714226


rs11876749




SUMMARY

Your brain may not receive these signals until you realize that you have consumed more calories.Try to include more fiber (from plants, vegetables, beans, pulses) in your diet since it increases thesense of satiety. You may want to develop strategies like sitting down for a meal, slowing down when eating, chewyour food more, introducing more proteins and fibers in your diet, high response costs foods such assoups, non starchy veggies and salads, healthy drinks and water in between meals.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Satiety Impairment3 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically risky compared to the general population.

WHATISSATIETYIMPAIRMENT

Satiety refers to the physical sensation of fullness from eating. When satiety is normal, the brain receives asignal that enough calories have been consumed, reducing the feeling of hunger. People with geneticvariations in the FTO, LEPR and DNMT3B genes are more likely to be eating more without feeling full andsatisfied.There is also a correlation between low satiety and weight gain. Genetic variation associated withlow satiety are also linked to higher consumption of high-sugar and high-fat foods.

WHATTODO


SATIETYIMPAIRMENT

YOU:

65SLIGHTLYELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs1137101, rs9939609, rs992472







SUMMARY

You may want to consider reducing your daily intake of sodium well below the recommended 2300mgs. Some ways to reduce salt intake include: limiting processed and prepared foods, eating fresh ratherthan packaged meats, choosing fresh fruit and vegetables.Read food labels to look for hidden salt in foods like bread, bagels, cottage cheese or pies.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Sensitivity To Salt11 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISSENSITIVITYTOSALT

Sodium, the primary element we get from salt, is essential for life. It is important for multiple body functionsfrom maintaining the proper balance of water and minerals, to conducting nerve impulses, and musclecontractions. Too much sodium in the diet can lead to fluid retention, and high blood pressure. If thisbecomes chronic, it can lead to heart disease, stroke, kidney disease and congestive heart failure.Individuals vary considerably in their response to sodium intake, and salt-sensitivity (a measure of how yourblood pressure responds to salt intake) is at least in part determined by genetics. The mechanismsunderlying salt sensitivity are complex. The kidney is critical to overall fluid and electrolyte balance and long-term regulation of blood pressure.

SENSITIVITYTOSALT

YOU:

95ELEVATED


WHATTODO

You may want to consider reducing your daily intake of sodium well below the recommended 2300 mgs. Some ways to reduce salt intake include: limiting processed and prepared foods, eating fresh ratherthan packaged meats, choosing fresh fruit and vegetables.Read food labels to look for hidden salt in foods like bread, bagels, cottage cheese or pies.Salt preference is an acquired taste that can be unlearned. It takes about 6-8 weeks to get used toeating food with much lower quantities of salt, but once it is done, its actually difficult to eat foodslike potato chips because they taste way too salty.Among people who are salt-sensitive, excess sodium intake in the long term may result in high bloodpressure, heart problems, increased calcium loss in the urine, osteoporosis, stomach cancer, orasthma.If you see these symptoms regularly, discuss your concerns with your physician.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1805152, rs7571842, rs7961152, rs1739843, rs699, rs9402571, rs2758151, rs4149601, rs2288774,rs1010069


rs11674786













SUMMARY

You are likely to see typical skeletal muscle performance improvements in response to training.Consider diets rich in anti-oxidants, which are thought to contribute positively to skeletal muscleperformance.Some exercises that will help you strengthen your skeletal muscles include:

Pull-down (or alternatively chin-up)Chest pressCompound row (A pulling motion in the horizontal plane)

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Skeletal MusclePerformance1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 50% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISSKELETALMUSCLEPERFORMANCE

Muscles such as biceps, pectorals and quadriceps are called skeletal muscles because they attach to theskeleton to generate motion. Skeletal muscles are composed of very long, thin cells that include the fullcomplement of organelles needed for general cellular functions. In addition, more than 90 percent of the totalvolume of a skeletal muscle cell is composed of muscle proteins, including the contractile proteins actin andmyosin. When a muscle cell is activated by its nerve cell, the interaction of actin and myosin generates forcethrough so-called power strokes. The total force depends on the sum of all the power strokes occurringsimultaneously within all of the cells of a muscle. Skeletal muscle is one of three major muscle types, theothers being cardiac muscle and smooth muscle. Your skeletal muscle can bear a high load at constantlength, or shorten rapidly when the load is low.

Uncoupling proteins 2 and 3 (UCP2 and UCP3) may negatively regulate mitochondrial ATP synthesis and,through this, influence human physical performance. A study found that genetic variants in the UCP3/2 genelocus are associated with training-related improvements in skeletal muscle performance.

SKELETALMUSCLEPERFORMANCE

YOU:

50TYPICAL


WHATTODO

You are likely to see typical skeletal muscle performance improvements in response to training.Consider diets rich in anti-oxidants, which are thought to contribute positively to skeletal muscleperformance.Some exercises that will help you strengthen your skeletal muscles include:Pull-down (or alternatively chin-up)


As always, consult with a personal trainer when engaging in a new exercise routine.

NATUREVS.NURTURE


GENETICVARIATIONS



rs659366





SUMMARY

You may experience longer muscle repair times than the average population. To ensure your muscles heal faster after an injury, you need to make sure to eat enough good qualityproteinAvoid trans-fats, saturated fat, and omega-6-rich vegetable oils.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Slow Muscle Repair8 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 90% of the population and is consideredstatistically risky compared to the general population.

WHATISSLOWMUSCLEREPAIR

Are you one of those people who take a very long time to heal after a muscle injury? Prolonged strenuousexercise, like high intensity weight training, results in activation of inflammatory factors. Genetic variants inseveral genes enhance the inflammatory response that may slow down the repair of muscle damagefollowing exercise. A person with higher predisposition to inflammation will benefit from less frequentexercise activities, and longer recovery periods. If the body is not fully recovered it may result in injuries,muscle straining and over-training. This is particularly important for high-intensity weight training athletes,and bodybuilders.

WHATTODO

You may experience longer muscle repair times than the average population. To ensure your muscles heal faster after an injury, you need to make sure to eat enough good qualityproteinAvoid trans-fats, saturated fat, and omega-6-rich vegetable oils.Consume monounsaturated and omega-3 fats have an anti-inflammatory effect.Include Vitamins D, B complex, C, and A, as well as calcium, copper, iron, magnesium, manganese,and zinc.To top it off, a good night's sleep does miracles to help accelerate muscle repair.

SLOWMUSCLEREPAIR

YOU:

90ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS















SUMMARY

As a general precaution, avoid excessive intake of sodium, coffee, wheat bran, and sugar. This helpsin reducing the risk for stress fractures.Additionally strengthening the calf muscles have been shown to have a substantial impact onpreventing stress fractures from happening. Try the following exercise to strengthen your calf muscles:


MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Stress Fracture9 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically low compared to the general population.

WHATISSTRESSFRACTURE

Stress fractures are small cracks in a bone. Stress fractures are caused by the repetitive application ofrepetitive movements, or force. For example, running long distances or repeatedly jumping up and down.Stress fractures can also arise from normal use of a bone that's been weakened. Anyone can experience astress fracture, but some people have higher predisposition which is associated with lower bone massdensity. Stress Fracture is a common overuse injury in repetitive sports. It affects up to 20% of athletes, inparticular female athletes. The major determinant of stress fracture risk is bone mineral density that has largegenetic component up to 85% of bone mineral density variability is explained by genetic variations). We useinformation on dozens of genetic variants to estimate your risk of stress fracture. Some genetic variationsincrease the risk of stress fracture while others have protective roles.

STRESSFRACTURE

YOU:

25NORMAL


WHATTODO

As a general precaution, avoid excessive intake of sodium, coffee, wheat bran, and sugar. This helps inreducing the risk for stress fractures.

Additionally strengthening the calf muscles have been shown to have a substantial impact onpreventing stress fractures from happening. Try the following exercise to strengthen your calf muscles:Use a resistance loop band or tie a long band into a loop 12" to 15" or 30 to 40 cm in diameter.Then, loop the resistance band around your foot with your toes pointed up toward the ceiling.Holding the band tight, push your foot and ankle down against the band as far as comfortable.


As always consult with a personal trainer before making any changes to your exercise routine.

NATUREVS.NURTURE


GENETICVARIATIONS



rs430727, rs227584, rs1373004, rs163879, rs7521902


rs1286083, rs3801387, rs12568930, rs4233949











SUMMARY

Take good care of your skin and bodyUse anti-aging skin-care products and supplements, appropriate for your ageEat a healthy diet and keep an active life-style

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for YouthfulnessNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 70% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISYOUTHFULNESS

People who have skin youthfulness genes experience look much younger than their actual age. The searchinto genetics of younger looking skin has recently yielded several genetic variations. Individuals with thesegenetic variations look years younger, and their facial skin showed fewer signs of aging. Youthfulness genesare not only important for external appearance. These genes are also believed to be associated with generalanti-aging and longevity.

WHATTODO


YOUTHFULNESS

YOU:

70TYPICAL


NATUREVS.NURTURE


GENETICVARIATIONS







Explore your fitness profile, benefits of fitness for your wellbeing, muscle characteristics and injury risk tooptimize

SportsandExerciseReports28 Reports in 5 groups


InjuryRisksWhile we all realize that exercise has tremendous benefits for our health, we also needto be aware of injury risks that come with doing the wrong kinds of exercises. Ourtendons and joints are structured differently. Explore how your unique genetic makeupmakes you more or less vulnerable to tendon and/or joint injury risks and getrecommendations on what exercises and routines to engage in or avoid.

PowerandStrengthExercisesThe muscle system is responsible for movement of the human body, posture, movementof substances inside the body and for the generation of body heat. Your overall musclepower and how much you can increase it with exercise depends strongly on yourgenetics. Your potentials for muscle injury, muscle cramps, muscle soreness afterexercise and other muscle problems are also influenced by your genes. Explore thegenetic basis of your muscle characteristics in this section.

AerobicExercisesSimilar to Power Exercises, you have genetic predispositions that would impact benefitsof Aerobic Exercises. In this group you can review reports such as Aerobic Performance,Heartbeat Reduction Difficulty, Exercise Benefits for Maximal Oxygen Uptake and more.


EnduranceExercisesHave you thought of or tried your city marathon? How about other athletics endurancesports? This set of reports will shed light on your body predispositions on your muscleperformance when it comes to endurance exercises.


SUMMARY

Your genetic risk for Achilles tendon injury seems to be low so you need to take ordinary measuresto protect your tendons.Try the following exercise to strengthen your calf muscles:


Avoid an abrupt change of exercise intensity.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Achilles Tendinopathy2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 15% of the population and is consideredstatistically low compared to the general population.

WHATISACHILLESTENDINOPATHY

Achilles tendon injury includes degenerative and painful conditions that affect athletes in a wide range ofsports, including up to 20% of runners. This is a multifactorial condition for which various genetic risk factorshave been identified. Genetic variants in the FBGN2, TNC and ADAMTS14 (metallopeptidase withthrombospondin) gene contribute to the reisk of achilles tendinopathy, while genetic variant in the MMP3 hasbeen found to be protective.

ACHILLESTENDINOPATHY

YOU:

15NORMAL


WHATTODO

Your genetic risk for Achilles tendon injury seems to be low so you need to take ordinary measures toprotect your tendons.

Try the following exercise to strengthen your calf muscles:Use a resistance loop band or tie a long band into a loop 12" to 15" or 30 to 40 cm in diameter.Then, loop the resistance band around your foot with your toes pointed up toward the ceiling.Holding the band tight, push your foot and ankle down against the band as far as comfortable.


Avoid an abrupt change of exercise intensity.Try to minimize high-impact sports, such as running which pose a higher risk for Achilles tendoninjury.Switch to low-impact sports, such as walking, biking or swimming, which can both strengthen yourmuscles and pose less of an injury risk.

NATUREVS.NURTURE


GENETICVARIATIONS



rs2104772


rs679620




SUMMARY

You have a slightly elevated advantage likelihood for this trait. This means your lung capacity may behigher than an average adult. As such you may be able to do more strenuous exercises than theaverage population. However before changing any part of your fitness routine, always consult with acertified personal trainer. To improve your aerobic fitness even further, exercise intensity needs to be between 70 and 85percent of your target heart rate. In order to calculate your target heart rate, you must first determineyour maximum heart rate, which is 220 minus your age in years.(Source: Livestrong)If you are new to exercise you should aim for 10 to 20 minutes of aerobic exercise per session. Overtime, gradually increase your exercise time until you can exercise continuously for 60 minutes.

MYASSESMENT

Good News! You seem to have some advantageous genetic predispositions for AerobicPerformance3 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically advantaged compared to the general population.

WHATISAEROBICPERFORMANCE

VO2 max (maximal aerobic capacity) is the maximum rate of oxygen uptake as measured during incrementalexercise, most typically on a motorized treadmill. Maximal oxygen uptake reflects the aerobic physicalfitness of the individual, and is an important determinant of their endurance capacity during prolonged,submaximal exercise. . Just a few of the benefits of aerobic fitness are lower blood pressure, lowercholesterol and less risk of obesity, Type II diabetes and heart disease. Aerobic performance measured asthe maximal rate of oxygen consumption (VO2max) is an important determinant of the endurance capacityduring prolonged exercise. VO2 max (V - volume, O2 - oxygen, max - maximum) is measured duringincremental exercise. Overall, maximal oxygen consumption reflects the aerobic physical fitness of theindividual, and it is widely accepted as the single best measure of cardiovascular fitness and maximalaerobic power. Absolute values of VO2 max are typically 40-60% higher in men than in women. Starting atabout the age of 30, our lung capacity begins to decrease. By the time we are 50 our lung capacity may behalf of what it was in our youth. Decreased lung capacity means respiratory function is impaired and less

AEROBICPERFORMANCE

YOU:

65SLIGHTLY

ADVANTAGED


oxygen is getting into our cells. This explains why shortness of breath, decreased endurance, andsusceptibility to respiratory illness commonly increases with age. We check for several genetic variants thatare associated with aerobic performance.

WHATTODO

You have a slightly elevated advantage likelihood for this trait. This means your lung capacity may be higherthan an average adult. As such you may be able to do more strenuous exercises than the averagepopulation. However before changing any part of your fitness routine, always consult with a certifiedpersonal trainer.

To improve your aerobic fitness even further, exercise intensity needs to be between 70 and 85percent of your target heart rate. In order to calculate your target heart rate, you must first determineyour maximum heart rate, which is 220 minus your age in years.(Source: Livestrong)If you are new to exercise you should aim for 10 to 20 minutes of aerobic exercise per session. Overtime, gradually increase your exercise time until you can exercise continuously for 60 minutes. This will mean allow you to do more strenuous exercises with the same amount of oxygen uptakecapacity.

NATUREVS.NURTURE


GENETICVARIATIONS



rs9922134, rs7191721


rs1572312





SUMMARY

You are at low genetic risk for anterior cruciate ligament (ACL) ruptures, but you may still benefitfrom exercises that require balance, power and agility.Jumping and balance exercises also help improve neuromuscular conditioning and muscularreactions and decrease the risk of ACL injury.It has also been suggested that drinking water before and after exercise may be beneficial for ACLinjury prevention.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Anterior Cruciate LigamentRupture4 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISANTERIORCRUCIATELIGAMENTRUPTURE

Anterior cruciate ligament (ACL) ruptures are considered to be the most severe joint injury in sports and isvery common in a sporting population. Athletes who participate in high demand sports like soccer, football,and basketball are more likely to injure their anterior cruciate ligaments. Athletes are involved with suddendeceleration of the body from jumping and forward running while the knee is in a shallow flexion angle. Onthe other hand, ACL injuries are not common among athletes involved in endurance sports, such as running,swimming, biking. About half of all injuries to the anterior cruciate ligament occur along with damage to otherstructures in the knee, such as articular cartilage, meniscus, or other ligaments.

Injured ligaments are considered "sprains" and are graded on a severity scale.

Grade1Sprains. The ligament is mildly damaged in a Grade 1 Sprain. It has been slightly stretched, but isstill able to help keep the knee joint stable.

Grade2Sprains. A Grade 2 Sprain stretches the ligament to the point where it becomes loose. This is oftenreferred to as a partial tear of the ligament.

ANTERIORCRUCIATELIGAMENTRUPTURE

YOU:

10NORMAL


Grade3Sprains. This type of sprain is most commonly referred to as a complete tear of the ligament. Theligament has been split into two pieces, and the knee joint is unstable.

There are some genetic variations that are commonly found in individuals with higher risk of ACL ruptures.

WHATTODO

You are at low genetic risk for anterior cruciate ligament (ACL) ruptures, but you may still benefit fromexercises that require balance, power and agility.

Jumping and balance exercises also help improve neuromuscular conditioning and muscularreactions and decrease the risk of ACL injury.It has also been suggested that drinking water before and after exercise may be beneficial for ACLinjury prevention.Some simple tips to reduce the risk of ACL ruptures:Alwayswarmupbeforeplaying. Get blood circulating to your muscles and joint before you startyour game or practice.

Stretch. Being flexible enough to move freely can help you maintain ideal form. Includestretches for your thighs, calves, and hips, and pay particular attention to any areas that areespecially tight.Strengthen. Having adequate strength in your hips and thighs is key to providing supportfor your knees and preventing ACL injuries. Squats and lunges are just a couple of exercisesthat can build strength.Balance. Many injuries occur when an athlete is off-balance. Like anything, balance getsbetter with practice. Your gains in stability will pay off on the playing field.Agility-ChangingDirection:Run to a line or cone, plant your outside foot without letting your knee collapse inward tochange direction.

Move in patterns that take you front to back, side to side and diagonally.Start byrunning slowly so you can concentrate on good position.Pick up the pace and maintain good technique.

As always consult with a personal trainer before changing your exercise routines.

NATUREVS.NURTURE



GENETICVARIATIONS



rs495366


rs1800012, rs970547, rs240736






SUMMARY


MYASSESMENT





YOU:

85ELEVATED



WHATTODO



NATUREVS.NURTURE


LEARNMORE







GENETICVARIATIONS



rs9939609, rs7903146, rs1440581, rs1801282, rs1800497, rs10830963










SUMMARY

While you do not seem to have genetically advantaged predispositions for elite endurance athletes,you can still enhance your endurance capacity through aerobic exercises. Aerobic exercises that you can include in your daily routine include stair climbing or stair master,elliptical trainer, indoor rower, stationary bicycles, treadmills, fast walking, cycling, running andskiing. Start with a run/walk plan that gradually and safely allows you to build up to an hour of steadyaerobic running.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Elite Endurance Athletes13 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 45% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISELITEENDURANCEATHLETES

Elite endurance athletes, such as distance runners, road cyclists and triathletes, excel in aerobicperformance. They are more likely to have higher proportion of slow-twitch (type I) muscle fibers. In addition,elite endurance athletes have a superior cardiovascular system that maintains optimal control of heart rate,stroke volume, and blood pressure. Elite athletes are likely to have increased fat oxidation capacity andhigher lactate threshold that ensures their muscles can function for longer periods of time. Assuming propernutrition and training, athletic endurance is, in simplest terms, limited by a human's ability to extract oxygenfrom the environment and deliver it to muscle cells that use it to generate energy. Silverberry computesgenetic predisposition likelihood for elite endurance based on 23 genetic variants, taking into accountgenetics-based endurance and aerobic performance scores.

ELITEENDURANCEATHLETES

YOU:

45TYPICAL


WHATTODO

While you do not seem to have genetically advantaged predispositions for elite endurance athletes, you canstill enhance your endurance capacity through aerobic exercises.

Aerobic exercises that you can include in your daily routine include stair climbing or stair master,elliptical trainer, indoor rower, stationary bicycles, treadmills, fast walking, cycling, running andskiing. Start with a run/walk plan that gradually and safely allows you to build up to an hour of steadyaerobic running.

NATUREVS.NURTURE


LEARNMORE

Learn more about Elite Endurance Athletes by checking out the following articles:

Endurance athletes who 'go against the grain' become incredible fat-burners Best Endurance Sports The Science Behind What Separates Elite Endurance Athletes From Everyone Else

GENETICVARIATIONS



rs4341, rs1815739, rs4343, rs7191721, rs1867785, rs11689011, rs2010963, rs4253765, rs8192678,rs11091046, rs12594956, rs9922134


rs1572312

https://www.sciencedaily.com/releases/2015/11/151117091234.htm

http://www.thetoptens.com/best-endurance-sports/

https://mic.com/articles/95460/the-science-behind-what-separates-elite-endurance-athletes-from-everyone-else















SUMMARY

Check out your power trait predisposition to explore if you may be more of a power athlete. While you may not have a genetic advantage for endurance, you can still include aerobic exercises inyour daily routine, including stair climbing or stair master, elliptical trainer, indoor rower, stationarybicycles, treadmills, fast walking, cycling, running and skiing. Start with a run/walk plan that gradually and safely allows you to build up to an hour of steadyaerobic running.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Endurance8 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 45% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISENDURANCE

Your muscle endurance measures your ability to repeat an activity for an extended period of time withoutgetting tired. If your muscle structure favors endurance you have the potential to thrive in exercises thatleverage your endurance. Cross-country skiing and push-ups are examples of endurance exercises.Theintrinsic capacity to perform endurance exercise is influenced by a number of factors. First of all, endurancedepends on the proportion of slow-twitch fibers in the skeletal muscle. Studies have identified a number ofgenetic variants associated with higher proportion of slow-twitch fibers, and higher oxygen supplies tomuscle tissues. Slow twitch fibers are also called red fibers because they contain more blood-carryingmyoglobin. The red muscles provide their own source of energy using oxidative phosphorylation to obtainATP. Therefore, slow-twitch fibers can sustain force for an extended period of time.

ENDURANCE

YOU:

45TYPICAL


WHATTODO

Check out your power trait predisposition to explore if you may be more of a power athlete. While you may not have a genetic advantage for endurance, you can still include aerobic exercises inyour daily routine, including stair climbing or stair master, elliptical trainer, indoor rower, stationarybicycles, treadmills, fast walking, cycling, running and skiing. Start with a run/walk plan that gradually and safely allows you to build up to an hour of steadyaerobic running.Consult with your fitness trainer on how to leverage this advantage to improve your fitness routines.As always, keep in mind that any substantial changes to your fitness routines may affect other partsof your well-being and should be done with proper oversight. Make sure to check your injury reports.

NATUREVS.NURTURE


GENETICVARIATIONS















SUMMARY

Knowing that the lack of motivation is partly genetic may help you more consciously overcome thislatent tendency in order to exercise more. Also you may want to focus more on fitness exercises thatwill show results faster.List the benefits of a regular exercise program, such as increased energy, weight loss, better sleep,reduced stress, improved mood, reduced risk of conditions like diabetes and heart disease, and amore satisfying sex life (Mayo Clinic)If you don't like the gym, practice yoga, take a dance class, go roller skating, take the dog on a hikeor just dance in your living room to your favorite music for 30 minutes.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Exercise Aversion8 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 75% of the population and is consideredstatistically risky compared to the general population.

WHATISEXERCISEAVERSION

Your motivation for physical activity is partly influenced by your genetics. How your body feels during aworkout (e.g oxygen transportation and lung capacity), and how you are predispositioned to respondmentally to the challenge all come down to your genetic makeup. Studies indicate that up to 50% of your likeor dislike for exercise comes down to your DNA. There is a difference between exercise aversion and a lackof motivation, where the former is a stronger inhibition factor. If you have specific genetic variations, it mayresult in a lower biological desire to engage in physical activity making exercise your least favorite activity.

EXERCISEAVERSION

YOU:

75SLIGHTLYELEVATED


WHATTODO

Knowing that the lack of motivation is partly genetic may help you more consciously overcome this latenttendency in order to exercise more. Also you may want to focus more on fitness exercises that will showresults faster.

List the benefits of a regular exercise program, such as increased energy, weight loss, better sleep,reduced stress, improved mood, reduced risk of conditions like diabetes and heart disease, and amore satisfying sex life (Mayo Clinic)If you don't like the gym, practice yoga, take a dance class, go roller skating, take the dog on a hikeor just dance in your living room to your favorite music for 30 minutes.Find an exercise partner who will hold you accountable and make workouts more fun. Plan aworkout schedule so you know in advance when you'll be working out. Make a commitment withyour friend to adhere to the schedule and keep each other motivated.

NATUREVS.NURTURE


GENETICVARIATIONS



rs12101846, rs2762527, rs2167270, rs238404, rs9633417


rs10946904, rs12405556, rs1766581










SUMMARY

You will probably achieve moderate improvements in your blood pressure thorugh moderateexercise. Regular exercise of at least 30 minutes per day, together with a healthy diet, will most likely result inlower blood pressure over time. Exercises that are useful for lowering your blood pressure include: Brisk walking , Cycling,Swimming, Dancing, Mowing the lawn, Tennis and Jogging.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Exercise Benefits ForBlood Pressure1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISEXERCISEBENEFITSFORBLOODPRESSURE

For most people, moderate-intensity exercise has been shown to lower blood pressure. In fact, aerobicexercise training is generally recommended as lifestyle therapy to prevent, treat and control hypertension.General guidelines call for at least half an hour of low intensity aerobic exercises, which helps to decreaseblood pressure. There is large variability in the individual response to the anti-hypertensive effect of exercise,and much of it is explained by genetic variations. Individuals with predisposition to increased hypertensionresponse, get to lower their blood pressure faster than the average population. For such individuals, thebenefits of this 30 minute exercise are more noticeable than for the average population.

EXERCISEBENEFITSFORBLOODPRESSURE

YOU:

25TYPICAL


WHATTODO

You will probably achieve moderate improvements in your blood pressure thorugh moderate exercise. Regular exercise of at least 30 minutes per day, together with a healthy diet, will most likely result inlower blood pressure over time. Exercises that are useful for lowering your blood pressure include: Brisk walking , Cycling,Swimming, Dancing, Mowing the lawn, Tennis and Jogging.Exercises you should avoid for blood pressure reduction: Weight lifting and sprinting. If you need to lower your blood pressure through exercise, you may want to increase its intensityunder the supervision of your physician or trainer. Please note that physical activity will temporarily cause your blood pressure to rise before it lowersyour blood pressure over time. So if you have high blood pressure, it is important to increase fitnessactivities gradually, and not to put too much strain on your heart. If your blood pressure is very high, you should not start any new activity without consulting yourdoctor.

NATUREVS.NURTURE


LEARNMORE

Learn more about Exercise Benefits For Blood Pressure by checking out the following articles:

Exercise: A drug-free approach to lowering high blood pressure

GENETICVARIATIONS



rs62205366



http://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/high-blood-pressure/art-20045206



SUMMARY


MYASSESMENT





YOU:

15TYPICAL


WHATTODO



NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY


MYASSESMENT





YOU:

90ADVANTAGED



WHATTODO



NATUREVS.NURTURE


GENETICVARIATIONS






















SUMMARY

You should see typical improvements in your heart beat as you continue to exercise. Try to exerciseto lower your heart beat rate below your maximum heart beat rate. The maximum heartbeat rate can be calculated by subtracting your age from 220. For example, ifyou're 45 years old, subtract 45 from 220 to get a maximumheart rate of 175. This is the maximumnumber of times your heart should beat per minute during exercise. The goal is however for your heartbeat rate to be between 50 to 70 percent of your maximum heartrate for moderate exercise and 70 to 85 percent of your maximum heart rate for vigorous exercise.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Heartbeat Reduction Difficulty7 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 20% of the population and is consideredstatistically low compared to the general population.

WHATISHEARTBEATREDUCTIONDIFFICULTY

Heart rate response is commonly used as a measurable marker to guide exercise intensity and to monitorprogress with the expectation that the heart rate at a given intensity and load will decrease substantially withregular exercise. Exercise training improves cardiac function and several cardiovascular risk factors,including ability to perform physical tasks at a given workload with a lower heart rate. However, thecardiovascular benefits of regular physical activity are not equally distributed among individuals, as someexhibit marked improvements while others may show little or no changes. If you have higher predispositionto reduced heart response to exercise, the expected decrease in exercise heart rate may not occur. You oryour fitness specialist may (falsely) assume that the exercise prescription was insufficient and may try toincrease the exercise training load. Genetic variation explains large proportion of this difference. It isimportant to know this to make sure that the exercise does not cause undue heart strain.

HEARTBEATREDUCTIONDIFFICULTY

YOU:

20NORMAL


WHATTODO

You should see typical improvements in your heart beat as you continue to exercise. Try to exercise tolower your heart beat rate below your maximum heart beat rate.

The maximum heartbeat rate can be calculated by subtracting your age from 220. For example, ifyou're 45 years old, subtract 45 from 220 to get a maximumheart rate of 175. This is the maximumnumber of times your heart should beat per minute during exercise. The goal is however for your heartbeat rate to be between 50 to 70 percent of your maximum heartrate for moderate exercise and 70 to 85 percent of your maximum heart rate for vigorous exercise. To calcuate your optimal/target heart rate during exercise usethiscalculator.(Opens new window)Always consult with your fitness trainer on any strenuous exercise.

NATUREVS.NURTURE


GENETICVARIATIONS



rs2253206, rs10932460, rs6435639, rs1876048, rs2360969, rs4759659, rs7597126



http://www.active.com/fitness/calculators/heartrate









SUMMARY

You can increase your joint flexibility by engaging in yoga exercises and other stretching exercises.Try the Hip Flexor exercise:

Assume a kneeling position and move one foot out to the front.Roll your hips forward and maintain an upright position with your upper body.You will feel this stretch in your back leg.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Joint Flexibility3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISJOINTFLEXIBILITY

While flexibility and range of motion can be improved with regular stretching, some people have inherentjoint flexibility that is a highly heritable trait. Genetic variants in several collagen genes alter amino acidsequence and change the amount of collagen proteins being produced affecting architecture andbiomechanical properties of some tissues, including ligaments. Therefore, people with these genetic variantsin general have higher range of motion and better joint laxity and flexibility. Interestingly, the research hasshown that violinists, flautists, and pianists with lax finger joints suffer less pain than their less flexible peers.An opposite spectrum of this is risk of non-contact soft tissue injuries while doing very active sports. Othergenetic variants in the collagen genes reduce joint flexibility and potentially protect from cruciate ligament,shoulder dislocation, and anterior cruciate ligament ruptures.

WHATTODO

You can increase your joint flexibility by engaging in yoga exercises and other stretching exercises.Try the Hip Flexor exercise:Assume a kneeling position and move one foot out to the front.

Roll your hips forward and maintain an upright position with your upper body.You will feel this stretch in your back leg.Hold the stretch for around a minute and repeat on the other side.

JOINTFLEXIBILITY

YOU:

25TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Joint Flexibility by checking out the following articles:

The Difference Between Mobility vs Flexibility, and How to Improve Them 7 ways to Improve Flexibility Flexibility, Mobility, and Stability

GENETICVARIATIONS



rs12722


rs970547, rs240736

http://vitals.lifehacker.com/mobility-vs-flexibility-the-difference-and-what-to-tra-1708380436

http://www.mensfitness.com/training/pro-tips/7-ways-improve-flexibility

https://www.fix.com/blog/flexibility-mobility-stability





SUMMARY




MYASSESMENT





JOINTINJURYRISK

YOU:

10NORMAL


WHATTODO




NATUREVS.NURTURE


GENETICVARIATIONS



rs16944, rs8044769, rs5009270







SUMMARY


MYASSESMENT





YOU:

50ADVANTAGED


WHATTODO





NATUREVS.NURTURE


GENETICVARIATIONS



rs1056513, rs2276541, rs12439003


rs6544334






SUMMARY

Your heart pump volume and effciency should increase as expected as you exercise more.Prolonged aerobic exercise training may also increase stroke volume, which frequently results in alower resting heart rate. Exercise can help strengthen your heart and improve how well it pumps blood to the rest of thebody. All it takes is 30 minutes a day of activity, even if that activity is walking.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Lower Exercise Benefits ForHeart Pump FunctionNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 35% of the population and is consideredstatistically low compared to the general population.

WHATISLOWEREXERCISEBENEFITSFORHEARTPUMPFUNCTION

Cardiac output is the volume of blood being pumped by the heart in a minute. It is equal to the heart ratemultiplied by the stroke volume. So if there are 70 beats per minute, and 70ml blood is ejected with eachbeat of the heart, the cardiac output is 4900 ml/ minute.

A large family study reported that a 20 week endurance training program resulted in a mean increase of 3.9ml/beat in stroke volume measured during steady-state exercise at 50 W (SV50) . Interestingly, the individualtraining responses ranged from a decrease of 41 ml/beat to an increase of 45 ml/beat. Carriers of a geneticvariant in the kinesin heavy chain (KIF5B) gene had lower SV50 training response than carries of the morecommon allele.

LOWEREXERCISEBENEFITSFORHEARTPUMPFUNCTION

YOU:

35NORMAL


WHATTODO

Your heart pump volume and effciency should increase as expected as you exercise more.Prolonged aerobic exercise training may also increase stroke volume, which frequently results in alower resting heart rate. Exercise can help strengthen your heart and improve how well it pumps blood to the rest of thebody. All it takes is 30 minutes a day of activity, even if that activity is walking. Exercises best for your heart health include brisk walking, running, interval training, cycling andswimming. Talk to your physician before engaging in strenous exercise or changing routines

NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY

There is no known genetic influences for your muscle cramping risk. Still make sure not tochange the intensity of your exercise abruptly.If you have muscle cramps, you have to focus on strengthening the exact muscle that isexperiencing the cramp.Here are directions for specific muscles. However it is best to talk to a trainer before engaging inexercise:

Lunges (Quadriceps,HamstringsandGluteals): Step 2 to 3 feet forward with your right footand lower you left knee toward the floor. Go down until your right thigh is parallel to thefloor. Keep your right knee in line with your ankle so that you can still see your toes. Returnto standing and repeat with left leg. Alternate right and left legs for each set. Start with noweight. When you can do 3 sets of 20 reps, do the exercise using resistance bands orholding dumbbells.Splitsquats (Quadriceps,HamstringsandGluteals): If you have a chronic knee injury, splitsquats are a good alternative to lunges. Step 2 to 3 feet forward with your right foot. Loweryour left knee toward the floor until your right thigh is parallel and come back up—that's onerep. Return to the starting position and lower your left knee again. Complete all 15repetitions with the right knee forward before switching legs. When you can do 3 sets of 20reps, add weight.Calfraises (GastrocnemiusandSoleus): Calf raises target both of the muscles that make upthe calf. Stand with the balls of your feet on a step or block with your heels hanging down.Rise up on balls of your feet until your toes are pointed down just as they would be at thebottom of your pedal stroke. Return to the starting position. When you can do 3 sets of 20reps, try single leg calf raises, switching legs after 15 reps.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Muscle CrampingNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISMUSCLECRAMPING

MUSCLECRAMPING

YOU:

30NORMAL


Muscle cramps can be caused by the overuse of a muscle, dehydration, muscle strain, or bad posture. Inaddition to potential risk factors such as inadequate blood supply, nerve compression, and mineraldepletion, muscle cramps are also influenced to a good extent by genetics. Individuals who have geneticvariants in the AMPD1 gene are significantly more likely to get muscle cramps and pains when they exercise.

WHATTODO

There is no known genetic influences for your muscle cramping risk. Still make sure not to change theintensity of your exercise abruptly.

If you have muscle cramps, you have to focus on strengthening the exact muscle that isexperiencing the cramp.Here are directions for specific muscles. However it is best to talk to a trainer before engaging inexercise:Lunges (Quadriceps,HamstringsandGluteals): Step 2 to 3 feet forward with your right foot andlower you left knee toward the floor. Go down until your right thigh is parallel to the floor. Keep yourright knee in line with your ankle so that you can still see your toes. Return to standing and repeatwith left leg. Alternate right and left legs for each set. Start with no weight. When you can do 3 setsof 20 reps, do the exercise using resistance bands or holding dumbbells.

Splitsquats (Quadriceps,HamstringsandGluteals): If you have a chronic knee injury, splitsquats are a good alternative to lunges. Step 2 to 3 feet forward with your right foot. Loweryour left knee toward the floor until your right thigh is parallel and come back up—that's onerep. Return to the starting position and lower your left knee again. Complete all 15repetitions with the right knee forward before switching legs. When you can do 3 sets of 20reps, add weight.Calfraises (GastrocnemiusandSoleus): Calf raises target both of the muscles that make upthe calf. Stand with the balls of your feet on a step or block with your heels hanging down.Rise up on balls of your feet until your toes are pointed down just as they would be at thebottom of your pedal stroke. Return to the starting position. When you can do 3 sets of 20reps, try single leg calf raises, switching legs after 15 reps.

Consult with a trainer before changing any routines.

NATUREVS.NURTURE



GENETICVARIATIONS







SUMMARY

While you may not have known genetic risks for muscle damage, to minimize the risk of a potentialmuscle tear, there are many steps you can take.For one, try not to sit in one position for too long and move about when working long hours in theoffice.Always stretch and warm up before and after engaging in exercise.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Muscle Damage Risk1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISMUSCLEDAMAGERISK

A muscle strain, or pulled muscle, occurs when your muscle is overstretched or torn. This usually occurs asa result of fatigue, overuse, or improper use of a muscle. Strains can happen in any muscle, but they’re mostcommon in your lower back, neck, shoulder, and hamstring, which is the muscle behind your thigh. Muscledamage can be caused by different reasons, including increased lactate oxidation, deficient lactate effluxpathways, or release of intracellular muscle components into the bloodstream. Mutations in some genes inthese pathways are associated with rare condition known as cryptic exercise intolerance. Common geneticvariation in the same genes have been found to be associated increased risk of muscle injury, musclecramping, and lactate accumulation in the muscle. This genetic variation has been associated withincidences of muscle injuries in elite football players. A predisposition to increased muscle damage risk canmean that you have to be more careful about lifting heavy weights or making sudden moves than theaverage person. Additionally, you may want to focus your exercises on those that improve the tenacity andflexibility of your muscles.

MUSCLEDAMAGERISK

YOU:

10NORMAL


WHATTODO

While you may not have known genetic risks for muscle damage, to minimize the risk of a potential muscletear, there are many steps you can take.

For one, try not to sit in one position for too long and move about when working long hours in theoffice.Always stretch and warm up before and after engaging in exercise.We are in a culture where pushing your limits is seen as a virtue, but it is good to be aware of thelimitations of one's body.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1860189





SUMMARY


MYASSESMENT




WHATTODO



YOU:

25TYPICAL


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



rs2296135, rs1805086, rs1137101


rs4634384







SUMMARY

You may experience more pronounced muscle soreness after exercise than the avergae population. Drinking coffee before exercise, having a protein shake, eating a low-fat, high-carb and high proteinnutrition bar, an adequate warm-up routine and staying hydrated are key to preventing musclesoreness.Additionally, electrolyte-rich foods like bananas or avocados are quite helpful in keeping the rightmineral balance within your muscles. Right before finishing your exercise routine, include 10 or sominutes of "easy aerobic work such as jogging or walking followed by stretching.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Muscle Soreness5 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISMUSCLESORENESS

The delayed onset muscle soreness refers to the feeling of soreness 12-24 hours after heavy exercise. It iscommonly understood to be the result of microscopic tears in your muscle tissue. The mild muscle straininjury creates microscopic damage to the muscle fibers and coupled with the resulting inflammation causesthe pain. The less fit you are, the more likely it is for your muscles to feel sore.

If you have a higher predisposition towards muscle soreness, you may want to only gradually increase theintensity of your workouts and concentrate more on endurance exercises that put less pointed pressure onyour muscles. Genetic variants in some inflammation-related genes (IGF2) were found to be related to thegreatest muscle soreness immediately after exercise, and highest post-exercise serum creatine kinaseactivity.

MUSCLESORENESS

YOU:

95ELEVATED


WHATTODO

You may experience more pronounced muscle soreness after exercise than the avergae population. Drinking coffee before exercise, having a protein shake, eating a low-fat, high-carb and high proteinnutrition bar, an adequate warm-up routine and staying hydrated are key to preventing musclesoreness.Additionally, electrolyte-rich foods like bananas or avocados are quite helpful in keeping the rightmineral balance within your muscles. Right before finishing your exercise routine, include 10 or sominutes of "easy aerobic work such as jogging or walking followed by stretching.Taking a cold shower after your exercise also minimizes the chance of inflammation.

NATUREVS.NURTURE


GENETICVARIATIONS



rs13266634, rs1799865, rs680, rs3213221, rs7924316









SUMMARY


MYASSESMENT





MUSCLESTRENGTHLOSS

YOU:

95ELEVATED


WHATTODO





NATUREVS.NURTURE


LEARNMORE





GENETICVARIATIONS



rs3213221, rs680, rs13266634, rs7924316








SUMMARY

You will probably gain musclar strength at typical rate when you exercise regularly.Weight training is the fastest way to build strength. Weight training increases the explosive powerathletes need for the power sports. Strength training not only increases power but it also aids withendurance.The most widely used method is lifting a weight that is 70% of your maximum 10-12 times. Yourepeat this three times with 1-5 minute breaks in between sets. Another thing to remember is thatyou should never repeat strength training on a specific muscle more than once every 48 hours. If youdo, you can cause numerous injuries and basically wear the muscle out so you recieve noimprovement at all.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Muscular StrengthNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISMUSCULARSTRENGTH

Muscularstrength is the amount of force a muscle can exert in a single contraction. Muscles have two typesof fibers, fast twitch and slow twitch. Fast twitch provide the explosive bursts of energy required in weightlifting and sprinting. Slow twitch fibers are for longer endurance type activities. Building fast twitch fibersrequires aerobic type activity such as sprinting. Slow twitch fibers depend on anaerobic exercise to gainstrength. Endurance type activities such as circuit training and long distance running build slow twitch fibers.Muscular strength is determined by fast twitch fibers which focus more on quick bursts of energy.

Is muscular strength a feature shared within your family? Familial studies have shown that up to 90% of thevariance in muscle mass and up to 60% of the variance in muscle strength are heritable. Furthermore,skeletal muscle force production is dependent on the properties of the muscle tissue. Two genetic variationshave been found to be significantly associated with muscular strength.

MUSCULARSTRENGTH

YOU:

30TYPICAL


WHATTODO

You will probably gain musclar strength at typical rate when you exercise regularly.Weight training is the fastest way to build strength. Weight training increases the explosive powerathletes need for the power sports. Strength training not only increases power but it also aids withendurance.The most widely used method is lifting a weight that is 70% of your maximum 10-12 times. Yourepeat this three times with 1-5 minute breaks in between sets. Another thing to remember is thatyou should never repeat strength training on a specific muscle more than once every 48 hours. If youdo, you can cause numerous injuries and basically wear the muscle out so you recieve noimprovement at all. Always consult with a professional trainer before you engage in any new exercise routine.

NATUREVS.NURTURE


LEARNMORE

Learn more about Muscular Strength by checking out the following articles:

Genetics and Strength Training: Just How Different Are We?

GENETICVARIATIONS






http://strengtheory.com/genetics-and-strength-training-just-different/


SUMMARY


MYASSESMENT






YOU:

5TYPICAL


WHATTODO



NATUREVS.NURTURE


GENETICVARIATIONS



rs62205366





SUMMARY

Your risk for overall tendon or ligament injury are within the typical range of the population. You maystill have more specific risks associated with Achilles tendons or ACL, so do check those traits. To reduce your chance of getting tendon injuriy we recommend to include stretching to increaseflexibility, plus eccentric strengthening of the gastrocnemius and soleus muscles.We recommend gastrocnemius/soleus eccentric strengthening, calf and Achilles stretches.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Overall Tendon And LigamentInjury Risk7 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISOVERALLTENDONANDLIGAMENTINJURYRISK

Non-contact tendon or ligament injury is an overuse injury associated with sports, and are a common causeof disability. Most major tendons, such as the Achilles, patellar, rotator cuff and forearm extensor tendons(amongst others) are vulnerable to overuse, which induces pathological changes in the tendon. Knowingyour genetic susceptibility to specific injury will help in customization of exercise recommendations,choosing the right prevention strategies like avoidance of weight-bearing and high-impact sports forindividuals who have risk profile genotypes would take advantage of this information.

WHATTODO

Your risk for overall tendon or ligament injury are within the typical range of the population. You may stillhave more specific risks associated with Achilles tendons or ACL, so do check those traits.

To reduce your chance of getting tendon injuriy we recommend to include stretching to increaseflexibility, plus eccentric strengthening of the gastrocnemius and soleus muscles.We recommend gastrocnemius/soleus eccentric strengthening, calf and Achilles stretches.It is also recommended to shift to running on softer surfaces.As always, consult with a personal trainer before making any changes to your routines.

OVERALLTENDONANDLIGAMENTINJURYRISK

YOU:

10NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs495366, rs2104772


rs970547, rs1800012, rs679620, rs240736, rs591058









SUMMARY


MYASSESMENT




OVERWEIGHTPOTENTIAL

YOU:

95ELEVATED


WHATTODO


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



rs9939609, rs1042714, rs1421085, rs17782313, rs1801282, rs12970134, rs10830963














SUMMARY

Given your advantage for power, you may excel at power exercises and sports.Power training enables you to apply the greatest amount of your maximal strength in the shortestperiod of time.Under the supervision of a trainer, you may build on this advantage further by doing ballistic trainingwhere yourlift, accelerate, and then release weighst, rather than slowly lowering it as in other formsof weight training.

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for Power6 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 80% of the population and is consideredstatistically advantaged compared to the general population.

WHATISPOWER

Your muscle power measures the maximum amount of force you can exert in a limited period of time. Whenyour muscle structure favors power exercises, you have the potential to exert substantial force in a shortperiod of time. Olympic weight lifting is an example of a power exercise. The heritability of power/strengthhas been estimated to be up to 80% depending on the specific muscle type (isometric knee strength,handgrip strength, elbow flexion). Fast-twitch (Type II) fibers generate a relatively high amount of force in ashort period of time. They are characterized by high force/power/speed, like the take-off motion in a sprint,but the fast-twitch muscle fibers experience fatigue faster. “Power” fibers have lower mitochondrial density,lower myoglobin levels but higher levels of stored glycogen as they primarily rely on glycosis (anaerobicrespiration) to fuel muscle contractions. The glycolysis process is very quick yet it is also quite inefficient atproducing ATP. Another drawback of glycolysis is that it produces lactic acid as a byproduct, which leads tomuscle fatigue. This explains why fast twitching muscles tire out quicker. To evaluate your power profilepredisposition likelihood Silverberry uses the most reliable genetic biomarkers that have been found to beassociated with power/strength-related sports.

POWER

YOU:

80ADVANTAGED


WHATTODO

Given your advantage for power, you may excel at power exercises and sports.Power training enables you to apply the greatest amount of your maximal strength in the shortestperiod of time.Under the supervision of a trainer, you may build on this advantage further by doing ballistic trainingwhere yourlift, accelerate, and then release weighst, rather than slowly lowering it as in other formsof weight training. Sports and exercises you may excel at include: Aerobics,high impact step, basketball, Martial Arts:judo, karate, kickboxing, downhill skiing and Tennis.As always, only change your fitness exercises under the supervision of a professional trainer.

NATUREVS.NURTURE


GENETICVARIATIONS



rs4343, rs1805086, rs1801282, rs1800795, rs2070744, rs2854464










SUMMARY

You are likely to see typical skeletal muscle performance improvements in response to training.Consider diets rich in anti-oxidants, which are thought to contribute positively to skeletal muscleperformance.Some exercises that will help you strengthen your skeletal muscles include:

Pull-down (or alternatively chin-up)Chest pressCompound row (A pulling motion in the horizontal plane)

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Skeletal MusclePerformance1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 50% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISSKELETALMUSCLEPERFORMANCE

Muscles such as biceps, pectorals and quadriceps are called skeletal muscles because they attach to theskeleton to generate motion. Skeletal muscles are composed of very long, thin cells that include the fullcomplement of organelles needed for general cellular functions. In addition, more than 90 percent of the totalvolume of a skeletal muscle cell is composed of muscle proteins, including the contractile proteins actin andmyosin. When a muscle cell is activated by its nerve cell, the interaction of actin and myosin generates forcethrough so-called power strokes. The total force depends on the sum of all the power strokes occurringsimultaneously within all of the cells of a muscle. Skeletal muscle is one of three major muscle types, theothers being cardiac muscle and smooth muscle. Your skeletal muscle can bear a high load at constantlength, or shorten rapidly when the load is low.

Uncoupling proteins 2 and 3 (UCP2 and UCP3) may negatively regulate mitochondrial ATP synthesis and,through this, influence human physical performance. A study found that genetic variants in the UCP3/2 genelocus are associated with training-related improvements in skeletal muscle performance.

SKELETALMUSCLEPERFORMANCE

YOU:

50TYPICAL


WHATTODO

You are likely to see typical skeletal muscle performance improvements in response to training.Consider diets rich in anti-oxidants, which are thought to contribute positively to skeletal muscleperformance.Some exercises that will help you strengthen your skeletal muscles include:Pull-down (or alternatively chin-up)


As always, consult with a personal trainer when engaging in a new exercise routine.

NATUREVS.NURTURE


GENETICVARIATIONS



rs659366





SUMMARY


MYASSESMENT




WHATTODO


SLOWMUSCLEREPAIR

YOU:

90ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS















SUMMARY

As a general precaution, avoid excessive intake of sodium, coffee, wheat bran, and sugar. This helpsin reducing the risk for stress fractures.Additionally strengthening the calf muscles have been shown to have a substantial impact onpreventing stress fractures from happening. Try the following exercise to strengthen your calf muscles:


MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Stress Fracture9 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically low compared to the general population.

WHATISSTRESSFRACTURE

Stress fractures are small cracks in a bone. Stress fractures are caused by the repetitive application ofrepetitive movements, or force. For example, running long distances or repeatedly jumping up and down.Stress fractures can also arise from normal use of a bone that's been weakened. Anyone can experience astress fracture, but some people have higher predisposition which is associated with lower bone massdensity. Stress Fracture is a common overuse injury in repetitive sports. It affects up to 20% of athletes, inparticular female athletes. The major determinant of stress fracture risk is bone mineral density that has largegenetic component up to 85% of bone mineral density variability is explained by genetic variations). We useinformation on dozens of genetic variants to estimate your risk of stress fracture. Some genetic variationsincrease the risk of stress fracture while others have protective roles.

STRESSFRACTURE

YOU:

25NORMAL


WHATTODO

As a general precaution, avoid excessive intake of sodium, coffee, wheat bran, and sugar. This helps inreducing the risk for stress fractures.

Additionally strengthening the calf muscles have been shown to have a substantial impact onpreventing stress fractures from happening. Try the following exercise to strengthen your calf muscles:Use a resistance loop band or tie a long band into a loop 12" to 15" or 30 to 40 cm in diameter.Then, loop the resistance band around your foot with your toes pointed up toward the ceiling.Holding the band tight, push your foot and ankle down against the band as far as comfortable.


As always consult with a personal trainer before making any changes to your exercise routine.

NATUREVS.NURTURE


GENETICVARIATIONS



rs430727, rs227584, rs1373004, rs163879, rs7521902


rs1286083, rs3801387, rs12568930, rs4233949











Explore your genetic skin characteristics. Reports include information about Skin Tanning, Sun Sensitivity,Collagen Breakdown, Antioxidant properties, Detoxification, Pollution defense, Youthfulness, Predispositionto acne and many more.

SkinCareReports20 Reports in 4 groups

SkinProfileYour basic skin profile determines what kind of skin care products are suitable for you.Whether you have predispositions for Acne or dry skin, or whether you have a higher riskfor eczema depends strongly on your genes. In this section explore your various skincare characteristics and learn how to choose the best skin care products for your uniqueskin needs.

SkinandAgingYour skin changes as you age. You might notice wrinkles, age spots and dryness. Yourskin also becomes thinner and loses fat, making it less plump and smooth. Sunlight is amajor cause of skin aging. You can protect yourself by staying out of the sun when it isstrongest, using sunscreen and wearing protective clothing. In this section, you canexplore how your genetic makeup impacts your skin as you age.

SkinDisordersThe skin uses sunlight to help manufacture vitamin D, which is important for normalbone formation. But sometimes its ultraviolet light can be very detrimental. A chemicalwithin the skin called Melanin protects it from the sun's ultraviolet rays, which can burnthe skin, and over time, could reduce its elasticity and cause photoaging. In this section,you can gain insights on how your genetic makeup influences how exposure to the sunimpacts your skin.

SkinSensitivitiesThe environment we live in is a crucial factor in maintaining the health of our skin. Ibelieve that a large portion of skin problems are due to irritants in the air such asautomobile exhaust and smoke from chemical factories as well as chemicals in ourenvironment. Dry and cracked skin are often caused by harsher winter weather andwhile we canâ€™t always avoid the effects of the weather and the environment, we cantry and protect ourselves. In this section, you can explore how your genetic makeupaffects your skin's sensitivity to environmental factors.


SUMMARY

Keep your face clean, use warm (not hot water) and mild facial cleanser.Avoid scrubbing your skin harshly and moisturize your skin.Stay out of sun.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Acne7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 80% of the population and is consideredstatistically risky compared to the general population.

WHATISACNE

Acne (acne vulgaris) is the most common in teenagers and young adults. It may occur in adult women andmen signaling hormonal imbalances. There are up to 3 million cases a year in the US. Of those affected,moderate to severe problems occur in 20%. Acne happens when hair follicles become clogged with deadskin cells and oil from the skin. Symptoms range from un-inflamed blackheads to pus-filled pimples or large,red, and tender bumps. In addition to hormonal changes and stress, genetics contributes to the likelihood ofacne.

WHATTODO

Keep your face clean, use warm (not hot water) and mild facial cleanser.Avoid scrubbing your skin harshly and moisturize your skin.Stay out of sun.Watch your diet: avoid spicy and fried foods.If you develop acne, try an over-the-counter acne product and if the symptoms persist, talk toa dermatologist.

ACNE

YOU:

80SLIGHTLYELEVATED


NATUREVS.NURTURE


LEARNMORE

Learn more about Acne by checking out the following articles:

Got Adult Acne? 4 Signs Your Hormones Are To Blame Acne Health Center Questions and Answers about Acne

GENETICVARIATIONS



rs747650, rs330071, rs7531806, rs38055, rs4671386, rs1159268, rs478304



http://www.mindbodygreen.com/0-12313/got-adult-acne-4-signs-your-hormones-are-to-blame.html

http://www.webmd.com/skin-problems-and-treatments/acne

http://www.niams.nih.gov/health_info/acne









SUMMARY

Consume collagen-rich foods like bone broth Reduce exposure to environmental factors (such as smoking, chlorinated water) that increase MMPlevelsUse skin care products rich in polyphenols, carotenoids, or flavonoids: topical agents such as asretinoids, including retinol (vitamin A), bioflavonoids including the proanthocyanidins from grapeseed extract, the polyphenols from green and white teas, soy phytoestrogens

MYASSESMENT

You seem to have elevated genetic predispositions risk for Collagen Breakdown2 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISCOLLAGENBREAKDOWN

Skin elasticity is the skin's ability to stretch and revert to its original form without developing wrinkles andimperfections. It is determined by collagen that makes up to 75 percent of our skin. Your skin's smoothness,firmness and elasticity depend on the balance between collagen synthesis and its breakdown. Levels ofMMPs increase in the course of normal aging, exposure to environmental factors, including UV, and irritation.In addition, genetic variants increase activity of MMPs contributing to accelerated loss of collagen andpremature skin aging.

COLLAGENBREAKDOWN

YOU:

95ELEVATED


WHATTODO

Consume collagen-rich foods like bone broth Reduce exposure to environmental factors (such as smoking, chlorinated water) that increase MMPlevelsUse skin care products rich in polyphenols, carotenoids, or flavonoids: topical agents such as asretinoids, including retinol (vitamin A), bioflavonoids including the proanthocyanidins from grapeseed extract, the polyphenols from green and white teas, soy phytoestrogensSip drinkable collagen for glowing skin Consider taking supplements that boost collagen production or inhibit MMPs. Think plypodiumleucotomos (available in oral capsules), lutein, and hops extract (xanthohumol)

NATUREVS.NURTURE


LEARNMORE

Learn more about Collagen Breakdown by checking out the following articles:

Is It Possible to Naturally Improve Skin Elasticity? Is It Possible to Naturally Improve Skin Elasticity? 7 Tips for Buying the Best Collagen Supplement Is drinking collagen the secret to a glowing complexion?

GENETICVARIATIONS



rs1799750, rs3918261



http://www.livestrong.com/article/537104-how-to-naturally-improve-skin-elasticity/

http://www.livestrong.com/article/281518-how-to-drink-collagen-for-the-skin/

http://www.renewalliance.com/blog/7-tips-for-buying-the-best-collagen-drink-beauty-supplement

http://www.wellandgood.com/good-looks/drinkable-collagen-skin-benefits/




SUMMARY

The presence of a positive family history may be a positive predictor of sensitivity to nickel and othermetals. In this case, watch out for symptoms of contact sensitivityIf you notice allergic symptoms on your skin after exposure to nickel or other metals, talk to yourhealthcare provider If you have sensitivity to nickel, you may also be sensitive to other metals, such as copper. Ascopper is believed to play an important role in maintaining healthy skin, one of the latest trends inskin-care is to use copper peptides in anti-aging products (and even in pillows!)

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Contact Skin Sensitivity1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically low compared to the general population.

WHATISCONTACTSKINSENSITIVITY

Contact skin sensitivities (contact allergy) are becoming more common all over the world. One of the mostprevalent types is allergic reaction to nickel or other metals.The rise of contact allergy can be due toincreased exposure to nickel in the environment: nickel is found in jewelry, belt buckles, watch straps, metalzips, bra hooks, buttons, pocket knives, lipstick holders, and powder compacts. Recent studies identifiedgenetic variations associated with the presence of nickel sensitivity. While there is an overlap with geneticfactors that increase risk of overall dermal sensitivity, some genetic variations have so far only been reportedin the context of allergic sensitivity to metals.

WHATTODO

The presence of a positive family history may be a positive predictor of sensitivity to nickel and other metals.In this case, watch out for symptoms of contact sensitivity

If you notice allergic symptoms on your skin after exposure to nickel or other metals, talk to yourhealthcare provider If you have sensitivity to nickel, you may also be sensitive to other metals, such as copper. Ascopper is believed to play an important role in maintaining healthy skin, one of the latest trends inskin-care is to use copper peptides in anti-aging products (and even in pillows!)

CONTACTSKINSENSITIVITY

YOU:

25NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs2367563





SUMMARY

While you may have one or more genetic variations associated with skin sensitivity, your overalldermal sensitivity score is within the typical risk for the gneeral populationFollow general recommendations to take care of your skin and bodyCheck reports on skin barrier function, skin inflammation and skin pollution defense

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Dermal Sensitivity4 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 20% of the population and is consideredstatistically low compared to the general population.

WHATISDERMALSENSITIVITY

Skin sensitivity is largely determined by the skin barrier function that determines skin permeability andprevents entry of harmful pathogens and toxins. In addition, hyperreactive immune response to allergens anddeficiency in protection from environmental toxins both contribute to overall skin sensitivity risk. In somecases, dermal sensitivity leads to atopic dermatitis, or eczema, which is in fact one of the most common skinconditions (with prevalence rates of up to 20% in children and 3% in adults in the developed world). Atopicdermatitis is characterized by very dry skin, and a typical age-related distribution of inflammatory lesions thatare frequently infected by bacteria and viruses. It is important to consult dermatologist if you experience anyof these symptoms. Your overall dermal sensitivity risk is calculated using the results from a large genome-wide study, where a number of genetic variants associated with increased risk of skin sensitivity wasidentified.

WHATTODO

While you may have one or more genetic variations associated with skin sensitivity, your overall dermalsensitivity score is within the typical risk for the gneeral population

Follow general recommendations to take care of your skin and bodyCheck reports on skin barrier function, skin inflammation and skin pollution defense

DERMALSENSITIVITY

YOU:

20NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Dermal Sensitivity by checking out the following articles:

Pediatric Atopic Dermatitis Treatment & Management 20 Common Questions About Sensitive Skin SNPwatch: New Genetic Insight into the Causes of Eczema

GENETICVARIATIONS



rs2234922, rs4520482, rs10994675, rs6661961



http://emedicine.medscape.com/article/911574-treatment

http://www.webmd.com/beauty/skin/sensitive-skin-20-questions

http://blog.23andme.com/23andme-research/snpwatch/snpwatch-new-genetic-insight-into-the-causes-of-eczema/






SUMMARY


MYASSESMENT


WHATISDRYNESS


WHATTODO


DRYNESS

YOU:

45NORMAL


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS










SUMMARY

Follow general guidelines to protect your facial skin from the UV exposureUse sunscreen. Apply moisturizer with SPF throughout the yearMonitor any changes in thei color, size or texture of moles and other skin lesions

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Facial Pigmented Spots2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically low compared to the general population.

WHATISFACIALPIGMENTEDSPOTS

Facial pigmented spots (solar lentigines and seborrheic keratosis) are a common feature of aging skin, andusually result sun exposure. With age, the repeated UV exposure causes melanin, a compound responsiblefor pigmentation as well as protecting the skin, to cluster or clump together, forming an area of hyper-pigmentation. Pigmented age spots develop earlier and are more pronounced in Asian than in Caucasianskin. While there are some similarities in manifestation of pigmented spots in different populations(determined by the MC1R ASIP IRF4 BNC2 genes), there are also ethnic differences. The SLC45A2 genehave been found to be associated with pigmented spots in Asian but not in Caucasian women.

WHATTODO

Follow general guidelines to protect your facial skin from the UV exposureUse sunscreen. Apply moisturizer with SPF throughout the yearMonitor any changes in thei color, size or texture of moles and other skin lesionsVisit dermatologist regularly to do a full-body check

FACIALPIGMENTEDSPOTS

YOU:

5NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Facial Pigmented Spots by checking out the following articles:

How to Get Rid of Dark Spots on Your Face Pigmentation explained: Everything you need to know How to Remove Brown Pigment Spots From the Face

GENETICVARIATIONS



rs463701


rs3843706

http://www.wikihow.com/Get-Rid-of-Dark-Spots-on-Your-Face

http://www.cosmopolitan.co.uk/beauty-hair/a19890/what-is-pigmentation-and-how-to-treat-it/

http://www.livestrong.com/article/181821-how-to-remove-brown-pigment-spots-from-the-face/




SUMMARY





MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Photoaging5 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 35% of the population and is consideredstatistically low compared to the general population.

WHATISPHOTOAGING

Skin photoaging is defined as premature aging of the skin due to sun exposure. It is among the most widelyappreciated harmful effects of chronic exposure to solar UV radiation. UV radiation causes DNA damage,oxidative stress, and disrupts normal architecture of skin connective tissue that impair skin function. Whileeveryone is experiencing skin photoaging, numerous data suggest that extrinsic skin aging parameters havea strong genetic basis. Large studies have identified genetic variations in STXBP5L and FBXO40 genesassociated with overall photoaging global scale score that combines pigmentation irregularities, sagging,and wrinkles. The analysis controlled for age, smoking history, hormonal status, body-mass index, hair colorat age 20, and other factors, and included estimation of lifetime sun exposure and intensity. A recent studyfound that the MC1R gene, that is responsible for pale skin and red hair, is also linked to increased aging.Interestingly, scientists discovered that associations between genetic variants in the MC1R gene andperceived age held true even after adjusting for skin tone, and wrinkling.

PHOTOAGING

YOU:

35NORMAL


WHATTODO





NATUREVS.NURTURE


LEARNMORE

Learn more about Photoaging by checking out the following articles:

Protect Against Sun-Induced Skin Aging From The Inside Out Gene linked to youthful looks has been discovered, scientists claim Genetic Secrets to Youthful Looks Revealed

GENETICVARIATIONS



rs17740066, rs322458, rs470647, rs6782033, rs6775899



http://www.lifeextension.com/magazine/2014/7/protect-against-sun-induced-skin-aging-from-the-inside-out/page-01

https://www.theguardian.com/science/2016/apr/28/gene-linked-to-youthful-looks-has-been-discovered-scientists-claim

https://www.scientificamerican.com/article/genetic-secrets-to-youthful-looks-revealed/







SUMMARY

1 Living in a big city with higher pollution levels? Reduce exposure to environmental pollutants (cigarettesmoke, automobile emissions, benzene). Get plants that clean indoor air and spend more time in the parks

2 Protect your skin from air pollutants. Consider investing in good quality skin care products designed forcity inhabitants. Look for skin care products that contain antioxidants, and coenzyme Q10

3 Experts advise to put a high SPF even when it's cloudy as it provides an extra layer of protection

4 Cleansing your skin at night is also crucial to remove harmful toxins and microbes

5 Consider supplementing with ubiquinol (bioavailable form of coenzyme Q10), and antioxidants such asastaxanthin

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Pollution Defense Impairment3 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically risky compared to the general population.

WHATISPOLLUTIONDEFENSEIMPAIRMENT

Air pollution is the cause of increased signs of aging, dark spots and inflammation. The ChineseDermatologist Association has found that those living in highly polluted areas age 10 times faster than thosewho live in the countryside. It obviously applies to other big cities, where pollution levels are high. Twoimportant enzymes (EPHX1 and NQO1) protect our bodies and skin from highly reactive foreign chemicals(epoxides and quinones). Biotransformation enzyme EPHX1 plays critical part in preventing the systemicabsorption of epoxides by catalyzing them into less reactive water-soluble form. NQO1 converts coenzymeQ10 (ubiquinone) to its reduced form, ubiquinol, which scavenges free radicals in the mitochondria and skinlipid membrane. The coenzyme Q10 reductase is involved in detoxifying quinones, allowing them to be safelyreduced and excreted. In the skin, EPHX1 and NQO1 play important roles in preventing the systemicabsorption of toxins within the outer skin layer (epidermis). Genetic variants in the EPHX1 gene cause

POLLUTIONDEFENSEIMPAIRMENT

YOU:

65SLIGHTLYELEVATED


epoxide hydrolase deficiency while SNPs in the NQO1 gene slow down production of ubiquinol. Individualswho have reduced levels of these two enzymes have significantly diminished skin protection defense fromenvironmental toxins.

WHATTODO

1 Living in a big city with higher pollution levels? Reduce exposure to environmental pollutants (cigarettesmoke, automobile emissions, benzene). Get plants that clean indoor air and spend more time in the parks

2 Protect your skin from air pollutants. Consider investing in good quality skin care products designed forcity inhabitants. Look for skin care products that contain antioxidants, and coenzyme Q10

3 Experts advise to put a high SPF even when it's cloudy as it provides an extra layer of protection

4 Cleansing your skin at night is also crucial to remove harmful toxins and microbes

5 Consider supplementing with ubiquinol (bioavailable form of coenzyme Q10), and antioxidants such asastaxanthin

NATUREVS.NURTURE


GENETICVARIATIONS



rs2234922, rs2917666, rs1800566







SUMMARY

Follow general recommendations to make sure your skin does not get excessive damage due to UVexposureAlways wear sunscreen with SPF40 or higher Monitor any changes in the color, size or texture of moles and other skin lesions

MYASSESMENT

You seem to have elevated genetic predispositions risk for Poor Tanning Ability7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically risky compared to the general population.

WHATISPOORTANNINGABILITY

Tanning is the physiologically stimulated response to ultraviolet (UV) radiation of the solar light. UV exposureincreases the production of eumelanin, a type of pigment melanin, that darkens the skin in an attempt toprotect it from the damage. Ability of skin to tan is variable and is determined by genetics. Many genes areinvolved in the production of melanin that is the substance that gives skin, hair, and eyes their color. Largestudies identified a number of genetic variants in the key pigmentation genes that are associated withtanning phenotype. Variants in the tyrosinase (TYR) gene variants encode skin color. MC1R gene is stronglyassociated with red hair, freckling and sun sensitivity: nearly all red-heads have genetic variants in the MC1Rgene, and hence diminished ability to tan. Similarly, genetic variants adjacent to OCA2 gene give lighter colorto the eyes. Another genetic variants of OCA2 is involved in the light skin tone in East Asians. People with anumber of genetic variants in the pigmentary genes tend to have lighter eye color, fair skin, and diminishedability to tan.

WHATTODO

Follow general recommendations to make sure your skin does not get excessive damage due to UVexposure

Always wear sunscreen with SPF40 or higher Monitor any changes in the color, size or texture of moles and other skin lesionsVisit dermatologist regularly to do a full-body check

POORTANNINGABILITY

YOU:

85ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs10831496, rs4785763, rs1393350, rs1015362, rs4911414, rs11648785, rs1805008











SUMMARY

Follow general rules to minimize cellulite by maintaining healthy weight: stay active and eat a healthydietStay hydratedTry daily dry skin brushing to improve circulation

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Protection From SkinCelluliteNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 80% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISPROTECTIONFROMSKINCELLULITE

Cellulite is a condition when skin on thighs, hips, buttocks and abdomen appears lumpy because of excessof fat beneath the skin. It is most common in women than men and even thin people can have it. There aremany causes of cellulite including excessive weight, total body fat, poor diet, fad dieting, lack oh physicalactivity, dehydration, hormone changes, and genetic predisposition. A small study of 200 lean women withcellulite and 200 BMI-matched controls identified two variations in ACE and HIF1A genes that weresignificantly associated with appearance of cellulite. Larger studies are on the way and we will keep youupdated. Many treatments for cellulite, including massages, cellulite creams, lasers, injections, are on themarket, advertise remarkable results. Most of these treatments will work only in combination with healthyactive lifestyle.

WHATTODO

Follow general rules to minimize cellulite by maintaining healthy weight: stay active and eat a healthy dietStay hydratedTry daily dry skin brushing to improve circulationUse anti-cellulite creams. Recent clinical studies have suggested that caffeine-containing creams areeffective in reducing the orange skin appearance caused by cellulite

PROTECTIONFROMSKINCELLULITE

YOU:

80TYPICAL


NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY


MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Sagging Eyelids Risk2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISSAGGINGEYELIDSRISK

Sagging eyelids (hooded eyes or dermatochalasis) are a frequent concern in middle-aged and older adults. Ithappens due to a loss of elastic fibers and a disruption of the collagen network. Sagging eyelids are usuallya cosmetic concern, although they can cause visual field loss, ocular or eyelid irritation. They may also be acause of headaches due to forced brow elevation to increase the visual field. A recent large scale studyidentified nearly 30 genetic variations associated with sagging eyelids. These variations are located in 6different genetic regions that contain four genes TGIF1, SMYD3, ATP8A1, and PJA2. Interestingly, some ofthe identified genetic variations, including variation in the TGIF1 gene (an inducer of transforming growthfactor β) have protective effect, others are associated with increased incidents of sagging eyelids.

WHATTODO


SAGGINGEYELIDSRISK

YOU:

10NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs6714226


rs11876749




SUMMARY

The best defense against sunburns is preventionChose your sunscreen carefully. Always wear sunscreen with SPF40 or higher. Use broad-spectrumprotection from both ultraviolet A and ultraviolet B raysSteer clear of the sun during peak hours (10am-4pm). Wear a hat with a brim

MYASSESMENT

You seem to have elevated genetic predispositions risk for Sensitivity To Sun7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically risky compared to the general population.

WHATISSENSITIVITYTOSUN

Humans vary over 1000-fold in their sensitivity to the harmful effects of ultraviolet radiation. Skinpigmentation, tanning ability and sensitivity to sun have high heritability. Several large-scale studiesidentified genetic variations that affect our skin sensitivity and tendency to get sun burns. The maindeterminants of sensitivity to sun are skin pigmentation genes (ASIP, TYR, MC1R, and OCA2) that are alsoassociated with poor tanning. In addition, skin DNA repair genes are strongly associated with tendency tosun burns, and increased risk of melanoma. Interestingly, the DNA repair genes (NTM, ERCC1) have noassociation in either direction with tanning ability. This implies that there is a pigmentation-independentmechanism underlying sunburn reaction.

WHATTODO

The best defense against sunburns is preventionChose your sunscreen carefully. Always wear sunscreen with SPF40 or higher. Use broad-spectrumprotection from both ultraviolet A and ultraviolet B raysSteer clear of the sun during peak hours (10am-4pm). Wear a hat with a brimRemember, that variants in DNA repair genes make people of all colors vulnerable to harmful effectof UV radiation. Monitor any changes in the color, size or texture of moles and other skin lesions Visit dermatologist regularly to do a full-body check

SENSITIVITYTOSUN

YOU:

85ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs13181, rs12421680, rs4785763, rs1393350, rs1015362, rs4911414, rs1805008











SUMMARY

1 Choose skin care that is rich with natural antioxidants (vitamin C, carotene, vitamin E, glutathione, greentea extract) that work together with your skin’s intrinsic antioxidants

2 During the day, the combination of antioxidants in day creams and sunscreens is a strong defense againstmany signs of aging, including wrinkles, discoloration, and dullness

3 Antioxidants in night creams promote cellular repair and healing

4 Consume antioxidant rich diet: include super foods, such as cruciferous vegetables, blueberries, redberries, dark green veggies, sweet potatoes, oranges, nuts, whole grains, and green tea

5 Consider supplements that boost master antioxidant NRF2

MYASSESMENT

You seem to have elevated genetic predispositions risk for Skin Antioxidant Deficiency6 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically risky compared to the general population.

WHATISSKINANTIOXIDANTDEFICIENCY

A balance between free radicals and intrinsic antioxidants is necessary for proper physiological function, aswell as youthful and healthy skin appearance. Increased amounts of free radicals start a dangerous chain ofreactions that target tissues and organs in the body, including skin, triggering many chronic and late onsetdiseases, and contributing to premature aging by damaging skin proteins and lipids. A master regulatorNRF2 (NF-E2-Related Factor 2) activated by oxidative stress and electrophiles induces a number ofantioxidative, detoxifying and cytoprotective enzymes and proteins, including SODs (superoxide dismutases)and CAT (catalase). These enzymes protect skin from oxidative damage by converting free radicals into lessharmful products: CAT mitigates the toxic effects of hydrogen peroxide, while SOD2 destroys superoxideanion radicals. Activities of these enzymes are modulated by natural aging, and exposure to UV andpollution. In addition, genetic variations in NRF2, SOD2 and CAT genes result in reduced antioxidantactivities in nearly all cell and increased risk of damage of skin lipids and proteins.

SKINANTIOXIDANTDEFICIENCY

YOU:

85ELEVATED


WHATTODO

1 Choose skin care that is rich with natural antioxidants (vitamin C, carotene, vitamin E, glutathione, greentea extract) that work together with your skin’s intrinsic antioxidants

2 During the day, the combination of antioxidants in day creams and sunscreens is a strong defense againstmany signs of aging, including wrinkles, discoloration, and dullness

3 Antioxidants in night creams promote cellular repair and healing

4 Consume antioxidant rich diet: include super foods, such as cruciferous vegetables, blueberries, redberries, dark green veggies, sweet potatoes, oranges, nuts, whole grains, and green tea

5 Consider supplements that boost master antioxidant NRF2

NATUREVS.NURTURE


GENETICVARIATIONS



rs6721961, rs2300181, rs35652124, rs769217, rs769214, rs4880










SUMMARY

Follow general recommendations to take care of your skin and bodyCheck reports on overall skin sensitivity, skin inflammation and skin pollution defense

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Skin Barrier Sensitivity1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 55% of the population and is consideredstatistically low compared to the general population.

WHATISSKINBARRIERSENSITIVITY

Skin barrier serves a crucial protective function for the skin preventing entry of harmful microbes, toxins, andallergens, and maintaining proper skin hydration. Skin barrier function is performed primarily in the outermostlayer of the epidermis called the stratum corneum (SC) that plays important functions in thermoregulationand innate immunity. Genetic variations in the Flaggirin (FLG) gene may cause skin barrier defects increasingits permeability and promoting skin sensitivity and irritation. In more extreme cases, genetic variations in theFLG gene are also associated with eczema and allergies. In up to 10% persons of European ancestry, partsof the FLG gene are deleted. This has been shown to strongly predispose people to atopic dermatitis, as wellas asthma, and severe allergies. People with sensitive skin barrier are three times more likely to suffer from apeanut allergy. In other people variations in the FLG gene may be the cause of sensitive or hypersensitiveskin.

WHATTODO

Follow general recommendations to take care of your skin and bodyCheck reports on overall skin sensitivity, skin inflammation and skin pollution defense

SKINBARRIERSENSITIVITY

YOU:

55NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs6661961





SUMMARY

1 To help your body maintain glutathione activity, consume diet rich in cruciferous vegetables; alsoeat vegetables high in sulfur, including garlic and onions

2 Minimize your toxic burden to maintain your naturally produced glutathione levels

3 If you feel sluggish, consider supplementation of glutathione or cruciferous vegetable extract. Naturalproduction of glutathione drops by roughly 10% per decade

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Skin Detoxification ImpairmentNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 15% of the population and is consideredstatistically low compared to the general population.

WHATISSKINDETOXIFICATIONIMPAIRMENT

Human skin maintains a sophisticated detoxification system that converts environmental toxins and reactiveoxygen species (ROS) into water-soluble forms by a mechanism called conjugation with glutathione.Glutathione is a master detoxifier produced naturally by the liver. It is also found in fruits, vegetables, andmeats. Glutathione also plays critical role in maintaining optimal levels of vitamins C and E. Geneticvariations in several enzymes (transferases and peroxidases) are known to lower glutathione activitycompromising its detoxification capacity, and resulting in accumulation of ROS. Insufficient ROSdetoxification may result in cellular damage, and may contribute to skin inflammation and premature aging,and increase individual's susceptibility to environmental toxins, including cigarette smoke, and automobileemissions.

SKINDETOXIFICATIONIMPAIRMENT

YOU:

15NORMAL


WHATTODO

1 To help your body maintain glutathione activity, consume diet rich in cruciferous vegetables; alsoeat vegetables high in sulfur, including garlic and onions

2 Minimize your toxic burden to maintain your naturally produced glutathione levels

3 If you feel sluggish, consider supplementation of glutathione or cruciferous vegetable extract. Naturalproduction of glutathione drops by roughly 10% per decade

NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY

Introduce more complex carbs in your dietMonitor your sugar intakeConsume diet rich in polyphenols and antioxidants to promote healthy blood sugar and protect yourface against glycation

MYASSESMENT

You seem to have elevated genetic predispositions risk for Skin Glycation4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISSKINGLYCATION

Our bodies use glucose as its main source of fuel. If glucose is not metabolized properly, it can bind to skin’scollagen and elastin fibers, forming abnormal cross-links, leading to structural and functional tissueimpairment, and producing advanced glycation products (AGEs). This process, called glycation, is heavilyimplicated in accelerated aging of the skin as it impairs skin’s ability to regenerate and self-repair. Glycationhas been described as caramelization (hardening) of the skin from the inside out. The skin-damaging effectsof glycation cause wrinkles, dryness, skin laxity. Scientific research identified several genetic variations inNAT2, GLO1 and AGER genes are associated with excessive glycation. A recent large-scale study found thatso-called slow NAT2 acelytator types have higher levels of AGEs in their skin. Genetic variations in theglyoxalase 1 enzyme (GLO1) that protects cells from AGEs lower this enzyme activity leading to the build-upof AGEs. Another gene implicated in glycation and skin aging is AGER receptor. Binding of AGE’s to AGERresult in activation of collagen breakdown enzymes and the pro-inflammatory cytokines.

SKINGLYCATION

YOU:

95ELEVATED


WHATTODO

Introduce more complex carbs in your dietMonitor your sugar intakeConsume diet rich in polyphenols and antioxidants to promote healthy blood sugar and protect yourface against glycationUse skin-care products that contain anti-glycation agents: green tea or extract of blueberries andpomegranate are good examplesTake plant based glycation inhibitors and glycation reversing agents such as salacia, fennugreek,cinnamon, turmeric, ginseng, gymnema, banaba, kudzu

NATUREVS.NURTURE


GENETICVARIATIONS



rs4921914, rs1800624, rs1049346, rs1130534








SUMMARY

Follow the general advice to take care of your skinIf your skin gets signs of inflammation, use anti-inflammatory over the counter products and talk todermatologistCheck your genetic-based predispositions to overall dermal sensitivity and susceptibility to woundinfection

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Skin Inflammation2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically low compared to the general population.

WHATISSKININFLAMMATION

Skin inflammation is a result of the complex biological process when the cells in the skin has a hyperactiveresponse to allergens or toxins by producing inflammatory hormones, called cytokines and chemokines.There are two types of inflammation, acute and chronic. Acute inflammation is a signal to the skin to start therepair process after being exposed to triggering stimulus, such as germs, environmental toxins. Acuteinflammation is a natural reaction that usually lasts a few days. It is required for wounds and infections toheal. When inflammation is chronic and serves no purpose, it becomes destructive, and damages the skin.There are a number of stimuli that induce chronic inflammation including overexposure to UV rays; stress;toxins, such as pollution and smoking; trauma; alcohol; immune reactions; and infection by pathogens andforeign bodies, such as dirt and debris. Chronic skin inflammation can also be triggered by excess of freeradicals. In addition, genetic variations in several pro-inflammatory and anti-inflammatory cytokines genesare reported to be associated with higher risks of chronic skin inflammation. Chronic inflammation playsimportant role in overall skin sensitivity, and susceptibility to wound infection.

SKININFLAMMATION

YOU:

5NORMAL


WHATTODO

Follow the general advice to take care of your skinIf your skin gets signs of inflammation, use anti-inflammatory over the counter products and talk todermatologistCheck your genetic-based predispositions to overall dermal sensitivity and susceptibility to woundinfection

NATUREVS.NURTURE


GENETICVARIATIONS



rs1800797


rs1800871




SUMMARY

If you have a tendency to blush or flush more easily, monitor the triggersMake a skin-care plan to control the symptomsIf you notice rosacea symptoms (flushing, redness, bumps, pimples, small visible blood vessels),seek medical advice. If diagnosed earlier, rosacea symptoms can be controlled, and reversed

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Skin RosaceaNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISSKINROSACEA

Rosacea is a common but often overlooked chronic skin condition. According to the US National Rosaceaassociation well over 16 million Americans may have rosacea and most of them don't know it. Rosaceacannot be cured, but it can be controlled. It is a chronic and potentially life-disruptive disorder primarily ofthe facial skin, often characterized by flare-ups and remissions. Individuals with fair skin who tend to flush orblush easily are believed to be at greatest risk of rosacea but it can affect all segments of the population.Many causes of rosacea have been proposed: from alcohol excess (especially red wine), sun exposure, toskin surface microbes and small intestinal bacterial overgrowth. Some people report that spicy foods, hotbaths and emotional stress trigger rosacea symptoms. Genetics is a big factor in developing rosacea. Alarge study has recently identified a several genetic variations significantly associated with rosacea.Interestingly, these variations have links to allergies, and other autoimmune diseases. Bill Clinton and Diana,Princess of Wales have struggled with rosacea.

WHATTODO

If you have a tendency to blush or flush more easily, monitor the triggersMake a skin-care plan to control the symptomsIf you notice rosacea symptoms (flushing, redness, bumps, pimples, small visible blood vessels),seek medical advice. If diagnosed earlier, rosacea symptoms can be controlled, and reversed

SKINROSACEA

YOU:

30NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY

Preempt stretch marks: it is always much better to prevent than to cureMaintain healthy weightIf you are pregnant, or experiencing weight gain/loss, look after your skin. Apply organic oil (such asargan oil) to your skin to maintain skin's elasticity, prevent the breakdown of essential structuralproteins like collagen and elastin, and aid the skin to rejuvenate itself by the natural regeneration ofelastin and collagen at the cellular level

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Skin Stretch Marks2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 70% of the population and is consideredstatistically low compared to the general population.

WHATISSKINSTRETCHMARKS

Both men and women can get stretch marks (striae, singular stria or striae distensae) on several parts of theirbodies, including the belly, thighs, hips, breasts, upper arms, and lower back . Stretch marks are a form ofscarring on the skin: the marks often start off looking reddish and then appear with off-color hue. Stretchmarks are often the result of the rapid stretching of the skin dermis associated with rapid growth, weightchanges, pregnancy (usually during the last trimester) or hormonal changes associated with puberty,bodybuilding, hormone replacement therapy. Recent study identified several genetic variants (near elastingene, ELN) that are significantly associated with stretch marks.

WHATTODO

Preempt stretch marks: it is always much better to prevent than to cureMaintain healthy weightIf you are pregnant, or experiencing weight gain/loss, look after your skin. Apply organic oil (such asargan oil) to your skin to maintain skin's elasticity, prevent the breakdown of essential structuralproteins like collagen and elastin, and aid the skin to rejuvenate itself by the natural regeneration ofelastin and collagen at the cellular level

SKINSTRETCHMARKS

YOU:

70NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs7787362, rs3910516






SUMMARY


MYASSESMENT

You no not seem to have known advantageous genetic predispositions for YouthfulnessNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 70% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISYOUTHFULNESS

People who have skin youthfulness genes experience look much younger than their actual age. The searchinto genetics of younger looking skin has recently yielded several genetic variations. Individuals with thesegenetic variations look years younger, and their facial skin showed fewer signs of aging. Youthfulness genesare not only important for external appearance. These genes are also believed to be associated with generalanti-aging and longevity.

WHATTODO


YOUTHFULNESS

YOU:

70TYPICAL


NATUREVS.NURTURE


GENETICVARIATIONS







Explore your personality profiles, your learning predispositions, and your interpersonal tendencies.

PersonalityReports22 Reports in 3 groups

PersonalityProfileExplore your genetically influenced personality characteristics such as Anger Response,Morning Person, Optimism, Warrior Personality, Exploratory Behavior, AddictivePersonality, Worrier Personality and Impulsivity.

SkillsandAptitudesGet insights on how your genetics may impact your cognitive development with regardsto predispositions for Creativity, Music Performance Aptitude, Musical Creativity,Mathematical Aptitude, Memory Performance, Reading Aptitude and Learning fromMistakes.

MoodandAttitudeTAssess how your genetic makeup may influence some of your interactions in social andprofessional environment, including your predispositions for Empathy, LeadershipPotential, Agreeableness, Extraversion, and Sociability.


SUMMARY

You do not seem to have known genetic predispositions for addictive personality.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Addictive Personality15 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 60% of the population and is consideredstatistically low compared to the general population.

WHATISADDICTIVEPERSONALITY

This trait measures whether you have genetic predispositions that would increase your likelihood of havingan addictive personality. Addictions can come in a wide range of forms, including food, drugs, alcohol,gambling, pornography, or even fitness/exercise. Addictive personality refers to a particular set of personalitytraits that make an individual predisposed to developing addictions. Addictions can come in a wide range offorms, including food, drugs, alcohol, gambling, pornography, or even fitness/exercise. In addition to geneDRD2 that is implicated in reduced pleasure response, several other genetic variants have been found to beassociated with addictive behaviors such as excessive alcohol consumption and smoking.

WHATTODO

You do not seem to have known genetic predispositions for addictive personality.

NATUREVS.NURTURE


ADDICTIVEPERSONALITY

YOU:

60NORMAL


LEARNMORE

Learn more about Addictive Personality by checking out the following articles:

Do You Have an Addictive Personality? 5 Signs You Have An Addictive Personality

GENETICVARIATIONS



rs10891549, rs1800497, rs4142041, rs2836823, rs1229984, rs13160562, rs165774, rs6902771,rs2810114, rs7590720, rs4478858, rs1344694, rs1451240, rs4440177, rs1000579



http://www.webmd.com/mental-health/addiction/features/do-you-have-addictive-personality

http://www.mindbodygreen.com/0-15682/5-signs-you-have-an-addictive-personality.html

















SUMMARY

You score has advantaged for predisposition likelihood for agreeableness.If you are in a leadership position at work, this may help you build strong teams that have highcohesion.On the potentially negative side, you may dread making tough decisions and provide negativefeedback even if it is necessary.

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for Agreeableness4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically advantaged compared to the general population.

WHATISAGREEABLENESS

Agreeableness is a personality trait manifesting itself in individual behavioral characteristics that areperceived as kind, sympathetic, cooperative, warm and considerate. It is one of the Big Five personalitytraits. A person with a high level of agreeableness in a personality test is usually warm, friendly, and tactful.They generally have an optimistic view of human nature and get along well with others. We learnagreeableness within our family structures and the social environments we grow up with. However researchshows that agreeableness is partially influenced by our genetics. Interestingly, the agreeableness has beenshown to be correlated with morningness. Indeed, the morningness allele of the circadian gene CLOCK issignificantly associated with agreeableness.

WHATTODO

You score has advantaged for predisposition likelihood for agreeableness.If you are in a leadership position at work, this may help you build strong teams that have highcohesion.On the potentially negative side, you may dread making tough decisions and provide negativefeedback even if it is necessary.

AGREEABLENESS

YOU:

95ADVANTAGED


NATUREVS.NURTURE


LEARNMORE

Learn more about Agreeableness by checking out the following articles:

What is Agreeableness Agreeableness in Personality: Definition & Overview How Agreeable Are You?

GENETICVARIATIONS



rs709160, rs2540226, rs1801260, rs1055356



https://www.123test.com/personality-agreeableness/

http://study.com/academy/lesson/agreeableness-in-personality-definition-lesson-quiz.html

http://www.truity.com/test/how-agreeable-are-you






SUMMARY

You seem to have a typical predisposition likelihood for anger response.This doesn't mean you don't ever get angry, but it may mean that your anger outbursts may not becaused by known genetic variations.While anger is a natural and legitimate emotion, it is important to manage it to avoid hurting others orone's own sense of peace.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Anger Response6 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 55% of the population and is consideredstatistically low compared to the general population.

WHATISANGERRESPONSE

Individuals with higher anger response are more irritable and likely to get angry as a result of unsettlingexternal stimuli. This is partially a result of the sensitivity of the central nervous system and the amygdala toexternal shocks and can be influenced by your genetics.

WHATTODO

You seem to have a typical predisposition likelihood for anger response.This doesn't mean you don't ever get angry, but it may mean that your anger outbursts may not becaused by known genetic variations.While anger is a natural and legitimate emotion, it is important to manage it to avoid hurting others orone's own sense of peace.

ANGERRESPONSE

YOU:

55NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs555017, rs670292, rs12249434, rs2148710


rs7578047, rs2844775








SUMMARY

You have genetic variants found to be associated with general creativity.Creativity, like other personality phenomena, is a very complex trait that is driven by both nature andnurture.Everyone has their creative side, and has the potential to develop it further in any direction.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Creativity6 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 35% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISCREATIVITY

Several lines of evidence suggest that genetics contributes to creativity potential estimating that over 30% ofthe creativity is heritable. Studies explored genetic background of general creativity that includes visual,verbal, scientific, technical or physical fields. An interesting result is that DRD2 and COMT genes that areinvolved in dopamine transmission may act in coordination to contribute to creativity. The neuregulin 1 gene(NRG1) is associated with creativity in people with high intellectual and academic performance. The samegene has also been implicated in increased risk of psychological problems

WHATTODO

You have genetic variants found to be associated with general creativity.Creativity, like other personality phenomena, is a very complex trait that is driven by both nature andnurture.Everyone has their creative side, and has the potential to develop it further in any direction.This means it's up to you to allow yourself to be creative, be it in work, art, or personal life.

CREATIVITY

YOU:

35TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Creativity by checking out the following articles:

7 Ways to Boost Your Creativity Boosting your Creativity in 10 Great Ways What Is Creativity? 21 Authentic Definitions Youâ€™ll Love

GENETICVARIATIONS



rs4818, rs1417940, rs5993883, rs8064530, rs1375515, rs6994992



http://99u.com/articles/16136/7-ways-to-boost-your-creativity

http://www.lifehack.org/articles/lifestyle/boosting-your-creativity-10-great-ways.html

http://www.copyblogger.com/define-creativity/








SUMMARY

You seem to have a higher tendency to be empathetic than the average person. Try to leverage this positivetrait by contributing more to society and giving to others. This is likely to have higher happiness impact onyou than the average person.

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for Empathy4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically advantaged compared to the general population.

WHATISEMPATHY

Empathy is defined as the capacity to understand and share the actions, emotions and intentions of others.It is an important driver of human social behaviors and it has genetic component (as social interactions werelinked to survival during evolution). We test for genetic variations in two genes, OXTR and BDNF. The OXTRgene codes for oxytocin receptor that relates to empathy and stress reactivity in humans. Oxytocin is apowerful neurotransmitter and it is sometimes referred to as the cuddle or love hormone. It is connected tosuch life-affirming activities as maternal behavior, lactation, social bonding and sexual pleasure. Individualswith certain OXTR genotype performed better on the empathy test, feel less lonely, employ more sensitiveparenting techniques. Genetic variation in the brain-derived neurotrophic factor (BDNF) has also been foundto affect empathy and social perception: people with some alleles present more reactivity to emotionalstimuli. Studies also found that culture is an important moderator that shapes behavioral outcomesassociated with OXTR and BDNF genotypes.

WHATTODO

You seem to have a higher tendency to be empathetic than the average person. Try to leverage this positivetrait by contributing more to society and giving to others. This is likely to have higher happiness impact onyou than the average person.

EMPATHY

YOU:

85ADVANTAGED


NATUREVS.NURTURE


LEARNMORE

Learn more about Empathy by checking out the following articles:

OXTR gene produces differences in kind behaviour that people can spot in 20 seconds Be Mine Forever: Oxytocin May Help Build Long-Lasting Love When is comfort most comforting? When you've got a specific Oxytocin gene!

GENETICVARIATIONS



rs13316193, rs53576, rs6265, rs2254298



http://blogs.discovermagazine.com/notrocketscience/2011/11/15/oxtr-gene-produces-differences-in-kind-behaviour-that-people-can-spot-in-20-seconds/

http://www.scientificamerican.com/article/be-mine-forever-oxytocin/

http://blogs.scientificamerican.com/scicurious-brain/when-is-comfort-most-comforting-when-youve-got-a-specific-oxytocin-gene/






SUMMARY

You are a carrier of one risky allele in the DRD2 gene that has been associated with lower avoidance ofmistakes. This variant results in lower density of dopamine receptors and higher risk of addictive behaviors,including excessive alcohol consumption or overeating. Do not get angry at yourself if you make the samemistake again! Be aware that it can be in your genetics and develop strategies to overcome it. However beaware that there are a lot of non-genetic components such as your upbringing, education level andperspectives on life that affect your learning from mistakes. If you observe that certain destructive patternsrepeat themselves in your life, review the assumptions and perspectives you approach situations.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Experiential Learning Impairment1 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically risky compared to the general population.

WHATISEXPERIENTIALLEARNINGIMPAIRMENT

An exciting study published in the Science magazine in 2007 with the title "Genetically determineddifferences in learning from errors" looked at the role of neurotransmitter called dopamine in feedback-basedlearning and monitoring negative action. The experimental set-up involved neuroimaging brains of volunteerswhile they were involved in a probabilistic learning task. The goal was to find out whether genetic variant inthe dopamine D2 receptor gene has any effect on how people learned. The polymorphism in question isquite common and it often referred as DRD2-TAQ-IA (rs1800497). This polymorphism is known to modulatedopamine D2 receptor density. The less common A1 allele is associated with a reduction in D2 density by upto 30%. Neuroimaging study demonstrated that the A1-allele carriers with reduced dopamine D2 receptordensities learned to avoid actions with negative consequences less efficiently. Their posterior medial frontalcortex that is involved in feedback monitoring, responded less to negative feedback than others did. So, inaddition to higher risk of addictive behaviors, the carriers of the risk A1 allele demonstrate decreasedsensitivity to negative action consequences, which may actually explain an increased risk of developingaddictive behaviors. In other words, risk allele carriers are generally worse at avoiding the same errors. Thismay have various implications in their learning style.

EXPERIENTIALLEARNINGIMPAIRMENT

YOU:

85SLIGHTLYELEVATED


WHATTODO

You are a carrier of one risky allele in the DRD2 gene that has been associated with lower avoidance ofmistakes. This variant results in lower density of dopamine receptors and higher risk of addictive behaviors,including excessive alcohol consumption or overeating. Do not get angry at yourself if you make the samemistake again! Be aware that it can be in your genetics and develop strategies to overcome it. However beaware that there are a lot of non-genetic components such as your upbringing, education level andperspectives on life that affect your learning from mistakes. If you observe that certain destructive patternsrepeat themselves in your life, review the assumptions and perspectives you approach situations.

NATUREVS.NURTURE


LEARNMORE

Learn more about Experiential Learning Impairment by checking out the following articles:

Are You a Neophiliac?

GENETICVARIATIONS



rs1800497



http://scienceblogs.com/digitalbio/2008/06/17/some-people-never-learn-the-ge/



SUMMARY

You seem to have a higher predisposition to exploratory behavior than the average population. This maymean that you seek out more diversity and novelty in your experiences. On the positive side, this may resultin a desire to grow and experience. On the negative side, you may feel uninspired when new experiences donot abound.

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for ExploratoryBehavior7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 90% of the population and is consideredstatistically advantaged compared to the general population.

WHATISEXPLORATORYBEHAVIOR

Exploratory behavior, or Novelty Seeking, is one of 4 temperaments according to the Cloningerâ€™s modelof personality. The other three are Harm Avoidance, Reward Dependence, and Persistence. Exploratorybehavior reflects the tendency to respond strongly to novelty and cues for reward. Explorers have thetendency to crave stimulation and thrills; they tend to be attracted by large crowds and bright colors.Interestingly, exploratory behavior is influenced by specific neurotransmitter pathways in the brain and it hasa heritable genetic component.

WHATTODO


EXPLORATORYBEHAVIOR

YOU:

90ADVANTAGED


NATUREVS.NURTURE


LEARNMORE

Learn more about Exploratory Behavior by checking out the following articles:

Some people never learn: the genetics of learning from our mistakes What's New? Exuberance for Novelty Has Benefits The Perils of Novelty Seeking

GENETICVARIATIONS



rs3120665, rs1533665, rs4680, rs4131099, rs1800955, rs10176705, rs7600563



https://www.psychologytoday.com/blog/fulfillment-any-age/201203/are-you-neophiliac

http://www.nytimes.com/2012/02/14/science/novelty-seeking-neophilia-can-be-a-predictor-of-well-being.html

https://www.psychologytoday.com/blog/the-athletes-way/201311/the-perils-novelty-seeking









SUMMARY

You have a typical genetics-based predisposition likelihood for extroversion. This means you may either bemore introverted, or have an equal balance of introversion and extroversion. There are advantages anddisadvantages to both extroversion and introversion, but if you don't feel like mingling with the crowds orneed substantial down-time after extensive socializing, give yourself the time and space you need.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Extraversion5 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 20% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISEXTRAVERSION

Most people believe that an extrovert is a person who is friendly and outgoing. While that may be true, that isnot the true meaning of extroversion. Basically, an extrovert is a person who is energized by being aroundother people. This is the opposite of an introvert who is energized by being alone. Extroversion is heritablepersonality trait associated with numerous psychosocial, lifestyle and health outcomes. It is one of the BigFive personality traits (together with openness to experience, conscientiousness, agreeableness, andneuroticism). Meta-analysis of several studies reported several genetic variations that are significantlyassociated with Extroversion.

WHATTODO

You have a typical genetics-based predisposition likelihood for extroversion. This means you may either bemore introverted, or have an equal balance of introversion and extroversion. There are advantages anddisadvantages to both extroversion and introversion, but if you don't feel like mingling with the crowds orneed substantial down-time after extensive socializing, give yourself the time and space you need.

EXTRAVERSION

YOU:

20TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Extraversion by checking out the following articles:

Extraversion What Is Extroversion? Extraversion in Personality: Definition & Overview

GENETICVARIATIONS



rs79870297, rs2712162, rs8010306, rs2024488, rs1842129



https://www.123test.com/personality-extraversion/

https://www.verywell.com/what-is-extroversion-2795994

http://study.com/academy/lesson/extraversion-in-personality-definition-lesson-quiz.html







SUMMARY

You do not seem to have genetic predispositions that would increase your impulsivity personality. Yourgenetics-based impulsivity tendencies fall within the average range of the population. This may mean thatyou are more level-headed in making your daily decisions.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Impulsivity3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically low compared to the general population.

WHATISIMPULSIVITY

Impulsivity can be defined as rapid, unplanned behavior with little forethought of the consequences. Someimpulsivity contributes to optimal decision-making and it is advantageous in certain situations. However,high levels of impulsivity are linked to risky behaviors that may result in adverse consequences. Impulsivity isrelated to novelty and excitement seeking. The behavioral consequences of impulsivity are more commonamong adolescents and young adults, who are generally more likely to be impulsive and seeking excitement.In addition, male subjects tend to score higher on measures of impulsivity and excitement-seekingcompared with female subjects, a pattern observed in countries around the world. Like other personalitytraits, impulsivity is a multidimensional construct: it is generally assessed by self-report questionnaires.

WHATTODO

You do not seem to have genetic predispositions that would increase your impulsivity personality. Yourgenetics-based impulsivity tendencies fall within the average range of the population. This may mean thatyou are more level-headed in making your daily decisions.

IMPULSIVITY

YOU:

25NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Impulsivity by checking out the following articles:

How Impulsive Are You? The Genetics of Being Daredevil

GENETICVARIATIONS



rs1611115, rs8041675, rs1800955







SUMMARY

You have a slightly advantaged predisposition likelihood for leadership. Leverage your potential to bringpeople together to create value, be it at home, at work or in society. Leadership is much more than innatecharisma, it is the ability to effectively leverage your strengths and that of others collectively, to createsomething more substantial than you could alone. As such leadership can happen at every level of life.

MYASSESMENT

Good News! You seem to have some advantageous genetic predispositions for Leadership Potential1 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 55% of the population and is consideredstatistically advantaged compared to the general population.

WHATISLEADERSHIPPOTENTIAL

Were you born to lead? Leadership, and in particular charismatic leadership, is partially influenced by ourgenetics. Genetic differences are significantly associated with the likelihood that people take on leadershippositions. While some leadership skills can definitely be learned and/or honed, there are genetic variationsthat are associated with the passing of leadership ability down through generations.

WHATTODO

You have a slightly advantaged predisposition likelihood for leadership. Leverage your potential to bringpeople together to create value, be it at home, at work or in society. Leadership is much more than innatecharisma, it is the ability to effectively leverage your strengths and that of others collectively, to createsomething more substantial than you could alone. As such leadership can happen at every level of life.

LEADERSHIPPOTENTIAL

YOU:

55SLIGHTLY

ADVANTAGED


NATUREVS.NURTURE


LEARNMORE

Learn more about Leadership Potential by checking out the following articles:

Born to lead? Leadership can be an inherited trait, study finds

GENETICVARIATIONS



rs6311



https://www.ucl.ac.uk/news/news-articles/0113/15012013-leadership-genetics



SUMMARY

You seem to have a typical likelihood for this trait. This means your own efforts will determine how well youwill do on math.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Mathematical Aptitude9 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 35% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISMATHEMATICALAPTITUDE

Were you the one in the class who was quick to grasp all the math concepts in no time, the one whopreferred the dentistâ€™s chair to doing a math problem, or somewhere in between? Your math aptitude ofcourse depends on your family environment, the quality of your schooling and many other environmentalfactors. But research suggests that some people are naturally good at math, whereas other may need to putin extra effort to become good at it. There are known genetic variations that seem to contribute to the overallmathematical aptitude of individuals. Interestingly, about half of these genetic contributions are shared byindividuals who are also good at reading comprehension.

WHATTODO

You seem to have a typical likelihood for this trait. This means your own efforts will determine how well youwill do on math.

MATHEMATICALAPTITUDE

YOU:

35TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Mathematical Aptitude by checking out the following articles:

Same genes drive maths and reading ability Are math skills genetic? Try Numerical Reasoning Tests for Free

GENETICVARIATIONS



rs12613365, rs789859, rs6588923, rs363449, rs12199332, rs2300052, rs2809115


rs6947045, rs133885

https://www.ucl.ac.uk/news/news-articles/0714/080714_Same_genes_drive_maths_and_reading_ability

https://www.cnet.com/news/are-math-skills-genetic/

http://www.practiceaptitudetests.com/numerical-reasoning-tests/











SUMMARY


MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Memory Performance1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISMEMORYPERFORMANCE

Human memory is the result of many distinct mental processes, such as memory encoding, forgetting, andmodulation of memory strength by various stimuli. Memory has large inter-individual variability andsubstantial heritability. It depends on many genetic factors (it is a polygenic trait) and only a few of them havebeen characterized so far. We test 3 genetic variations that account for episodic memory (ability to recallwords and pictures) that have recently been identified. Genetic variation in the BAIAP2 gene is related tonegative emotional modulation of human memory strength. People who carry the minor A allele of rs8067235variant performed significantly better in recalling negative images compared to neutral pictures, while carriersof the major allele did not demonstrate any difference. Carriers of KIBRA rs17070145 T allele had 25% betterfree recall performance 5 min after word presentation and 20% better free recall performance 24 hours afterword presentation than did non-carriers.

WHATTODO


MEMORYPERFORMANCE

YOU:

5TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Memory Performance by checking out the following articles:

Gene Variation Affects Memory

GENETICVARIATIONS



rs17070145



http://www.genomenewsnetwork.org/articles/08_03/memory.shtml



SUMMARY


MYASSESMENT


WHATISMISOPHONIA


WHATTODO



MISOPHONIA

YOU:

5NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY

It seems you have an advantaged predisposition likelihood for being a morning person. This means you aremore likely to be more productive early mornings. Try to sleep earlier and wake up earlier during the day totake advantage of your morning personality. If you want to see how your actual mornignness compares withyour genetic predisposition, consider taking the following quiz (opens in a new window).

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for Morning Person5 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically advantaged compared to the general population.

WHATISMORNINGPERSON

Chronotype (also referred to as morningness-eveningness or diurnal preference) is the tendency to be anearly lark (alert and preferring to be active early in the day) or a late owl (alert and preferring to be active laterin the day). Chronotype is determined by circadian rhythms that are a nearly universal feature of livingorganisms and affect almost every biological process. Numerous studies suggest that genetics significantlycontributes to chronotype that has heritability of about 40-60%. This may explain why those of us who areearly-to-bed, early-to-rise types, or late-to-bed, late-to-rise types, find it so hard to change our behavior.Owls and larks are the two extremes with most individuals having some flexibility in the timing of their sleepperiod. Those in the middle are called hummingbirds, and may be ready for action both early and late. Somehummingbirds are more larkish, and others, more owlish. A recent study of nearly 90,000 people foundgenetic variations associated with being a morning person. Around 10% of people are primarily larks.Whether you are a lark (a morning person) or an owl (an evening person) is influenced by your genetics.Knowing if you are a morning person and would be most productive during morning hours could help youorganize your life such that your most creative tasks are scheduled in the morning.

WHATTODO

It seems you have an advantaged predisposition likelihood for being a morning person. This means you aremore likely to be more productive early mornings. Try to sleep earlier and wake up earlier during the day totake advantage of your morning personality. If you want to see how your actual mornignness compares withyour genetic predisposition, consider taking the following quiz (opens in a new window).

MORNINGPERSON

YOU:

85ADVANTAGED

https://www.surrey.ac.uk/features/sleep-quiz-are-you-owl-or-lark

https://www.surrey.ac.uk/features/sleep-quiz-are-you-owl-or-lark


NATUREVS.NURTURE


LEARNMORE

Learn more about Morning Person by checking out the following articles:

Why Night Owls Are More Intelligent Than Morning Larks Are You a Lark, an Owl, or a Hummingbird? Are You a Morning or an Evening Person?

GENETICVARIATIONS



rs7153587, rs7221412, rs12927162, rs1595824, rs2072293



https://www.psychologytoday.com/blog/the-scientific-fundamentalist/201005/why-night-owls-are-more-intelligent-morning-larks

https://www.nasw.org/users/llamberg/larkowl.htm

http://www.hhmi.org/biointeractive/are-you-morning-or-evening-person







SUMMARY

Congrats! You seem to have an advantaged predisposition likelihood for higher musical performanceaptitude. This indicates that you share specific traits with individuals known to have a higher ability inmusical performance. Like most other hobbies however, your excellence depends on how much effort youput into it and how much passion you have for it.

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for MusicPerformance Aptitude7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically advantaged compared to the general population.

WHATISMUSICPERFORMANCEAPTITUDE

Were you born with an inherent talent to be a musician? Musical aptitude has been shown to be influencedby certain genetic variations. Individuals with specific genetic variations have been shown to perform higheron the Bentley Musical Aptitude Test, which is used to assess a student's aural capacity before learning aninstrument.

WHATTODO

Congrats! You seem to have an advantaged predisposition likelihood for higher musical performanceaptitude. This indicates that you share specific traits with individuals known to have a higher ability inmusical performance. Like most other hobbies however, your excellence depends on how much effort youput into it and how much passion you have for it.

MUSICPERFORMANCEAPTITUDE

YOU:

85ADVANTAGED


NATUREVS.NURTURE


GENETICVARIATIONS



rs1293430, rs13146789, rs4148254, rs2225994, rs9854612, rs13109270, rs3057











SUMMARY

You have a typical genetics-based predisposition likelihood for music creativity. As other personality traits,music creativity is a complex trait driven by genetics as well as family, environment, and our personalinterests and hobbies. Genetic predisposition is only a potential advantage rather than a determinant ofcreativity. If music is your passion, creativity could be acquired through your openness to new ideas andforms.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Musical Creativity3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISMUSICALCREATIVITY

Musical creativity is the ability to create new forms of music and is most common associated withcomposition and improvisation within music. This is a different ability than music performance, as performersoften stress accuracy, whereas composers stress novelty and out of the box creativity. From scientific pointof view, musical creativity is a complex phenotype where a common background with musicality andintelligence has been proposed. A study of nearly 500 individuals from 79 families reported on geneticsassociated with music related creativity. Individuals with music aptitude who were engaged in arranging andcomposing music were found to possess certain genetic variants more frequently than controls, where somecontrols were playing various music instruments and other were not engaged in music activities at all. Whilethis is a small study, their analysis suggested the involvement of cerebellar long-term pathway that controlsbrain plasticity and memory, facilitating the acquisition of novel information.

WHATTODO

You have a typical genetics-based predisposition likelihood for music creativity. As other personality traits,music creativity is a complex trait driven by genetics as well as family, environment, and our personalinterests and hobbies. Genetic predisposition is only a potential advantage rather than a determinant ofcreativity. If music is your passion, creativity could be acquired through your openness to new ideas andforms.

MUSICALCREATIVITY

YOU:

10TYPICAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs4972527, rs4242493, rs737401







SUMMARY

You seem to have a typical predisposition for this trait.This does not mean you cannot be optimistic, it justmeans you don't have some traits that are shared by many individuals assessed to be naturally optimistic.Optimism heavily depends on your perspectives and decisions of how to see the world. People who areoptimist, generally tend to give up less rapidly, and interpret setbacks as temporary, local, and changeable.So do make an active choice to look at the glass half-full, it may allow you to withstand substantial stressand tolerate uncertainty better, in these increasingly stressful times.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Optimism3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 15% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISOPTIMISM

Optimism is the ability to see the glass half full and to look at the present and the future through cheerfuleyes. It is an important asset for creating energy to move forward in life and is a great coping mechanism foruncertain and tumultuous times like ours. Optimism has been shown to be partly influenced by yourgenetics. Recent studies have shown that there are genetic variations that contribute to optimism, self-esteem and agency, which can help individuals cope well with stress and avoid depression.

WHATTODO

You seem to have a typical predisposition for this trait.This does not mean you cannot be optimistic, it justmeans you don't have some traits that are shared by many individuals assessed to be naturally optimistic.Optimism heavily depends on your perspectives and decisions of how to see the world. People who areoptimist, generally tend to give up less rapidly, and interpret setbacks as temporary, local, and changeable.So do make an active choice to look at the glass half-full, it may allow you to withstand substantial stressand tolerate uncertainty better, in these increasingly stressful times.

OPTIMISM

YOU:

15TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Optimism by checking out the following articles:

Learning to Think Like an Optimist

GENETICVARIATIONS



rs4958581, rs2075677


rs3756290

https://www.psychologytoday.com/blog/high-octane-women/201112/learning-think-optimist





SUMMARY

You seem to have a typical predisposition for this trait. This only means you do not share genetic variationsthat are common for individuals with higher reading ability. Like most other cognitive abilities, reading abilityis a function of your family upbringing, education, social environment and personal interest in reading. Themore you read, the more you develop the neural pathways that make reading both pleasurable and easy. Ifthe written word is not your thing, do consider audio books.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Reading Aptitude20 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISREADINGAPTITUDE

Reading ability measures the processing and comprehension capacity of written language. Often, significantsimilarities can be observed among family members with regards to reading ability. While there is definitelyan environmental and social component, research has shown that genetics and heredity plays a major role inthe ability of people to process written language. There are known genetic variations that seem to contributeto the overall reading ability of individuals. Interestingly, about half of these genetic contributions are sharedby individuals who are also good at mathematical aptitude. Another interesting finding is that geneticvariations associated with reading abilities in English and Chinese overlap.

WHATTODO


READINGAPTITUDE

YOU:

25TYPICAL


NATUREVS.NURTURE


GENETICVARIATIONS





rs2179515, rs7765678, rs2038137, rs2038139, rs4504469, rs9461045, rs3212236, rs2143340,rs9467247, rs807701, rs1555090, rs1091047






















SUMMARY

Feeling blue in Winter? It is important to be aware of the possibility of SAD and your geneticpredispositionMonitor the changes in your mood when seasons change and make note of any such changes forfuture referenceIncrease your activity levels during such times to mitigate the impact of mood changes

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Seasonality4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 75% of the population and is consideredstatistically risky compared to the general population.

WHATISSEASONALITY

Seasonality or Seasonal affective disorder (SAD) is seasonal changes in mood and behavior. SAD begins andends at about the same times every year. Study of over 4000 individuals (Australians and Amish) identifiedseveral genetic variants with small additive effects that are significantly associated with SAD.

WHATTODO

Feeling blue in Winter? It is important to be aware of the possibility of SAD and your genetic predispositionMonitor the changes in your mood when seasons change and make note of any such changes forfuture referenceIncrease your activity levels during such times to mitigate the impact of mood changes

SEASONALITY

YOU:

75SLIGHTLYELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs1808478, rs1801260, rs11825064, rs13257657








SUMMARY

You do not seem to have genetic predispositions that would increase your emotional support needs. Youremotional needs levels fall within the average range of the population.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Sociability6 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISSOCIABILITY

Sociability is a complex, multidimensional construct. As humans we all have a universal need forinterpersonal relationships. Many people maintain rich social connections, boasting high-contact relationsacross numerous family members, co-workers and friends, while others possess only a few closerelationships, and in some instances, are largely socially isolated. Ability to form and maintain these bonds iscommonly characterized along two dimensions, social integration and social support. Social integrationreflects how extensively individuals are embedded in a social context, both by quantity of social contactsand diversity of social roles, whereas social support refers to the various types of assistance (e.g. emotionaland tangible) that people may receive from others or perceive to be available from others. Individualdifferences in social integration and quality of social support have been shown to be substantially heritable.Up to 70% for pro-social behaviors, including factors such as empathy, degree of social integration,availability of confidants, friend/relative social support is heritable. This implies that as individuals we areendowed with certain traits that affect our ability to form and maintain close relationships with others.Studies (of people of European, Asian, and African descent) have demonstrated that variability in socialbehavior is at least partly determined by genetic variations in the oxytocin receptor gene (OXTR) that is alsoassociated with empathy trait. In addition, pro-social tendencies are modulated by variants in the CLOCKgene. Interestingly, genetic variations in the CLOCK gene are strongly associated with being an eveningperson as well as an emotional eater.

SOCIABILITY

YOU:

30TYPICAL


WHATTODO

You do not seem to have genetic predispositions that would increase your emotional support needs. Youremotional needs levels fall within the average range of the population.

NATUREVS.NURTURE


GENETICVARIATIONS



rs53576, rs2268494, rs28373064, rs2254298, rs1042778, rs1801260










SUMMARY

You seem to have a higher warrior personality than the average population. This means that externalchallenges may awaken a fighter spirit within you. On the positive side, you may find challenges to be astimulus to your growth. On a potentially negative side, you may have a tendency to being moreconfrontational in situations that may not require it.

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for WarriorPersonality3 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically advantaged compared to the general population.

WHATISWARRIORPERSONALITY

Warrior have better stress resiliency, and higher pain threshold. In some circumstances, the warriorpersonality is associated with aggressiveness and violence when combined with trauma, drugs, oralcoholism. On a biochemical level, worrier personality is associated with two enzymes, MAOA and COMTthat determine the levels of several neurotransmitters such as dopamine and serotonin. Neurotransmittersplay a pivotal role in our reactions, moods and emotions. The MAOA has even been nicknamed the warriorgene and drew international attention a decade ago when it was reported that a common genetic variation tooccur more common in Maori â€” the indigenous Polynesians of New Zealand â€” than in whites. A recentstudy demonstrated that Finnish criminals convicted of several violent crimes possessed this variant morefrequently than nonviolent controls. Interestingly, a smaller study reported that the warrior genes often linkedwith aggression and alpha-male behavior in men might actually be the happiness genes for women.

WHATTODO

You seem to have a higher warrior personality than the average population. This means that externalchallenges may awaken a fighter spirit within you. On the positive side, you may find challenges to be astimulus to your growth. On a potentially negative side, you may have a tendency to being moreconfrontational in situations that may not require it.

WARRIORPERSONALITY

YOU:

95ADVANTAGED


NATUREVS.NURTURE


GENETICVARIATIONS



rs4680, rs6323, rs3027399







SUMMARY

You seem to have a slightly higher worrying personality. This means that external challenges may createanxiety and potentially drive you to resign to the challenges more easily. Knowing this to be a potentialpredisposition, try not to give up easily when challenges arise and make every effort to overcome anxietywhen circumstances get tough.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Worrier Personality1 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically risky compared to the general population.

WHATISWORRIERPERSONALITY

Worriers are more exploratory, have lower pain threshold and enhanced vulnerability to stress. They oftengive up when the going gets tough. Yet they may be more efficient processing information under mostconditions. On a biochemical level, worrier personality is associated with lower COMT enzyme activity.

WHATTODO

You seem to have a slightly higher worrying personality. This means that external challenges may createanxiety and potentially drive you to resign to the challenges more easily. Knowing this to be a potentialpredisposition, try not to give up easily when challenges arise and make every effort to overcome anxietywhen circumstances get tough.

WORRIERPERSONALITY

YOU:

65SLIGHTLYELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs4680





Either you are planning to gain or lose weight, your unique biology would impact your diet, exercise benefitsand more.

WeightManagementReports28 Reports in 5 groups

WeightProfileHave you asked yourself the question of why some people have more difficulty in losingweight? What is your overweight potential? What are your predispositions for lean bodymass potential? In this section you can gain an overall view on your weight profile andinsights on your unique biology.


MuscleBuildingThe muscle system is responsible for movement of the human body, posture, movementof substances inside the body and for the generation of body heat. Your overall musclepower and how much you can increase it with exercise depends strongly on yourgenetics. Your potentials for muscle injury, muscle cramps, muscle soreness afterexercise and other muscle problems are also influenced by your genes. Explore thegenetic basis of your muscle characteristics in this section.

FatFor our bodies consuming fat has different meaning. Some of us have differentperception of fate taste, our sensitivity to Trans Fats are different and even Low-Fat DietEffectiveness can be different based on our unique biology. Understanding yourpredispositions to Fat can inform and guide your plan for weight management, either tolose weight or gain it.


SugarDo you have a sweet tooth? What are your sweet snack preference? What are yourpredispositions for Glucose Level? How about low-carb Diet effectiveness for yourbody? Those are important items to consider in any weight planning and your genesinfluence your predispositions, how your body responses to sugar in your diet. In thissection, you explore the above items and more to understand how to incorporate sugarin your diet and what to watch for.


SUMMARY

You have a slightly elevated advantage likelihood for this trait. This means your lung capacity may behigher than an average adult. As such you may be able to do more strenuous exercises than theaverage population. However before changing any part of your fitness routine, always consult with acertified personal trainer. To improve your aerobic fitness even further, exercise intensity needs to be between 70 and 85percent of your target heart rate. In order to calculate your target heart rate, you must first determineyour maximum heart rate, which is 220 minus your age in years.(Source: Livestrong)If you are new to exercise you should aim for 10 to 20 minutes of aerobic exercise per session. Overtime, gradually increase your exercise time until you can exercise continuously for 60 minutes.

MYASSESMENT

Good News! You seem to have some advantageous genetic predispositions for AerobicPerformance3 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically advantaged compared to the general population.

WHATISAEROBICPERFORMANCE

VO2 max (maximal aerobic capacity) is the maximum rate of oxygen uptake as measured during incrementalexercise, most typically on a motorized treadmill. Maximal oxygen uptake reflects the aerobic physicalfitness of the individual, and is an important determinant of their endurance capacity during prolonged,submaximal exercise. . Just a few of the benefits of aerobic fitness are lower blood pressure, lowercholesterol and less risk of obesity, Type II diabetes and heart disease. Aerobic performance measured asthe maximal rate of oxygen consumption (VO2max) is an important determinant of the endurance capacityduring prolonged exercise. VO2 max (V - volume, O2 - oxygen, max - maximum) is measured duringincremental exercise. Overall, maximal oxygen consumption reflects the aerobic physical fitness of theindividual, and it is widely accepted as the single best measure of cardiovascular fitness and maximalaerobic power. Absolute values of VO2 max are typically 40-60% higher in men than in women. Starting atabout the age of 30, our lung capacity begins to decrease. By the time we are 50 our lung capacity may behalf of what it was in our youth. Decreased lung capacity means respiratory function is impaired and less

AEROBICPERFORMANCE

YOU:

65SLIGHTLY

ADVANTAGED


oxygen is getting into our cells. This explains why shortness of breath, decreased endurance, andsusceptibility to respiratory illness commonly increases with age. We check for several genetic variants thatare associated with aerobic performance.

WHATTODO

You have a slightly elevated advantage likelihood for this trait. This means your lung capacity may be higherthan an average adult. As such you may be able to do more strenuous exercises than the averagepopulation. However before changing any part of your fitness routine, always consult with a certifiedpersonal trainer.

To improve your aerobic fitness even further, exercise intensity needs to be between 70 and 85percent of your target heart rate. In order to calculate your target heart rate, you must first determineyour maximum heart rate, which is 220 minus your age in years.(Source: Livestrong)If you are new to exercise you should aim for 10 to 20 minutes of aerobic exercise per session. Overtime, gradually increase your exercise time until you can exercise continuously for 60 minutes. This will mean allow you to do more strenuous exercises with the same amount of oxygen uptakecapacity.

NATUREVS.NURTURE


GENETICVARIATIONS



rs9922134, rs7191721


rs1572312





SUMMARY


MYASSESMENT




WHATTODO


CARBOVERCONSUMPTION

YOU:

50NORMAL


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



rs838133, rs1542608, rs4702718, rs8019546


rs2840445








SUMMARY


MYASSESMENT





YOU:

85ELEVATED



WHATTODO



NATUREVS.NURTURE


LEARNMORE







GENETICVARIATIONS



rs9939609, rs7903146, rs1440581, rs1801282, rs1800497, rs10830963










SUMMARY

Knowing that the lack of motivation is partly genetic may help you more consciously overcome thislatent tendency in order to exercise more. Also you may want to focus more on fitness exercises thatwill show results faster.List the benefits of a regular exercise program, such as increased energy, weight loss, better sleep,reduced stress, improved mood, reduced risk of conditions like diabetes and heart disease, and amore satisfying sex life (Mayo Clinic)If you don't like the gym, practice yoga, take a dance class, go roller skating, take the dog on a hikeor just dance in your living room to your favorite music for 30 minutes.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Exercise Aversion8 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 75% of the population and is consideredstatistically risky compared to the general population.

WHATISEXERCISEAVERSION

Your motivation for physical activity is partly influenced by your genetics. How your body feels during aworkout (e.g oxygen transportation and lung capacity), and how you are predispositioned to respondmentally to the challenge all come down to your genetic makeup. Studies indicate that up to 50% of your likeor dislike for exercise comes down to your DNA. There is a difference between exercise aversion and a lackof motivation, where the former is a stronger inhibition factor. If you have specific genetic variations, it mayresult in a lower biological desire to engage in physical activity making exercise your least favorite activity.

EXERCISEAVERSION

YOU:

75SLIGHTLYELEVATED


WHATTODO

Knowing that the lack of motivation is partly genetic may help you more consciously overcome this latenttendency in order to exercise more. Also you may want to focus more on fitness exercises that will showresults faster.

List the benefits of a regular exercise program, such as increased energy, weight loss, better sleep,reduced stress, improved mood, reduced risk of conditions like diabetes and heart disease, and amore satisfying sex life (Mayo Clinic)If you don't like the gym, practice yoga, take a dance class, go roller skating, take the dog on a hikeor just dance in your living room to your favorite music for 30 minutes.Find an exercise partner who will hold you accountable and make workouts more fun. Plan aworkout schedule so you know in advance when you'll be working out. Make a commitment withyour friend to adhere to the schedule and keep each other motivated.

NATUREVS.NURTURE


GENETICVARIATIONS



rs12101846, rs2762527, rs2167270, rs238404, rs9633417


rs10946904, rs12405556, rs1766581










SUMMARY


MYASSESMENT





YOU:

15TYPICAL


WHATTODO



NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY


MYASSESMENT





YOU:

90ADVANTAGED



WHATTODO



NATUREVS.NURTURE


GENETICVARIATIONS






















SUMMARY


MYASSESMENT




WHATTODO



FATOVERCONSUMPTION

YOU:

30NORMAL


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



rs13290799, rs12327666







SUMMARY

You have a typical taste perception of fat, so you are a so-called super-taster of fat.This means that you are likely to perceive fats in your foods and avoid fatty food more readily. If you do taste too much fat in food trust your senses and do not continue eating that food.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Fat Taste PerceptionNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically low compared to the general population.

WHATISFATTASTEPERCEPTION

There is growing evidence that foods we crave are at least partially determined by our genetics. Geneticvariation in taste receptors (or taste buds) may account for differences in our food choices and dietaryhabits. Research reported that people with a variant in the CD36 gene do not taste dietary fats as much.These people crave fats more than people with who detect lower amounts of fats in food. In fact, there isconsistent emerging evidence that fat is the sixth primary taste, with some people being genetic super-tasters and others low-tasters of fat. Low fat taste perception is linked with dietary consumption of fattyfoods which in combination with other factors lead to extra weight.

WHATTODO


FATTASTEPERCEPTION

YOU:

5NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Fat Taste Perception by checking out the following articles:

Are You a Supertaster? Fat might be the sixth basic taste

GENETICVARIATIONS






http://theplate.nationalgeographic.com/2014/09/30/are-you-a-supertaster/

https://www.washingtonpost.com/national/health-science/fat-might-be-the-sixth-basic-taste/2012/06/04/gJQAt218DV_story.html


SUMMARY




MYASSESMENT





JOINTINJURYRISK

YOU:

10NORMAL


WHATTODO




NATUREVS.NURTURE


GENETICVARIATIONS



rs16944, rs8044769, rs5009270







SUMMARY


MYASSESMENT





YOU:

50ADVANTAGED


WHATTODO





NATUREVS.NURTURE


GENETICVARIATIONS



rs1056513, rs2276541, rs12439003


rs6544334






SUMMARY


MYASSESMENT




WHATTODO


NATUREVS.NURTURE



YOU:

55NORMAL


LEARNMORE



GENETICVARIATIONS



rs838133, rs1350036, rs9553939


rs9939609, rs1421085








SUMMARY


MYASSESMENT




WHATTODO




YOU:

65NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs1011397, rs3811787, rs6818288, rs1549059, rs2075577









SUMMARY


MYASSESMENT





YOU:

75ADVANTAGED




WHATTODO



NATUREVS.NURTURE


LEARNMORE








GENETICVARIATIONS



rs10850219, rs1042714, rs2306179, rs2241201, rs5883, rs7957619, rs3764261











SUMMARY


MYASSESMENT





YOU:

65SLIGHTLY

ADVANTAGED


WHATTODO



NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



















SUMMARY


MYASSESMENT






YOU:

85ADVANTAGED



WHATTODO



NATUREVS.NURTURE


GENETICVARIATIONS



rs1801133, rs13702, rs17300539








SUMMARY

Follow generally recommended guidelines for monounsaturated fats intake. Consumer olive oil and nuts to meet your daily intake needs.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Monounsaturated FatsIncreased Benefits3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 55% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISMONOUNSATURATEDFATSINCREASEDBENEFITS

In addition to tremendous health benefits of omega-3 (alpha linoleic acid) and omega-6 (linoleic acid) fats,there are several other fats that are important for good health. These include monounsaturated (healthier)fatty acids such as omega-7 (palmitoleic acid found in macadamia nuts, for example), omega-9 (oleic acidfound in olive oil), as well as some saturated fats (for example, those found in coconut oil or peanuts). Thesefats are known for their anti-inflammatory properties, lowering triglycerides, reducing blood pressure. TheMediterranean Diet, known for its numerous health benefits, is heavily influenced by monounsaturated fats.They are also good for keeping heart healthy. Good quality monounsaturated fats are also beneficial for skinas they maintain water level in the epidermis and supply the ceramides and fats that keep the bricks andmortar of the skin and hair healthy and intact.

WHATTODO


MONOUNSATURATEDFATSINCREASEDBENEFITS

YOU:

55TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Monounsaturated Fats Increased Benefits by checking out the following articles:

What Are the Benefits of Polyunsaturated Fat?

GENETICVARIATIONS



rs7597155, rs102275, rs3134950



http://www.livestrong.com/article/346100-what-are-the-benefits-of-polyunsaturated-fat/





SUMMARY


MYASSESMENT




WHATTODO



YOU:

25TYPICAL


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



rs2296135, rs1805086, rs1137101


rs4634384







SUMMARY


MYASSESMENT





MUSCLESTRENGTHLOSS

YOU:

95ELEVATED


WHATTODO





NATUREVS.NURTURE


LEARNMORE





GENETICVARIATIONS



rs3213221, rs680, rs13266634, rs7924316








SUMMARY


MYASSESMENT






YOU:

5TYPICAL


WHATTODO



NATUREVS.NURTURE


GENETICVARIATIONS



rs62205366





SUMMARY


MYASSESMENT




OVERWEIGHTPOTENTIAL

YOU:

95ELEVATED


WHATTODO


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



rs9939609, rs1042714, rs1421085, rs17782313, rs1801282, rs12970134, rs10830963














SUMMARY

You have genetic variations in or near the FADS enzymes that play key roles in fatty acidmetabolism, thereby requiring additional sources of omega-3 and omega-6 in your diet.While both omega 3 and omega6 fatty acids are essential, the goal is to increase the intake ofomega-3 fats while limiting the intake of omega-6 fats (from fried and processed foods).Aim to eat fish high in DHA and EPA omega-3 fatty acids two to three times a week.

MYASSESMENT

Good News! You seem to have some advantageous genetic predispositions for PolyunsaturatedFats Increased Benefits7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 70% of the population and is consideredstatistically advantaged compared to the general population.

WHATISPOLYUNSATURATEDFATSINCREASEDBENEFITS

Polyunsaturated fats are mainly omega-3 and omega-6 fatty acids. Omega-3 fats are a key family ofpolyunsaturated fats (EPA/DHA/ALA) that humans must get from food. Omega-3s are beneficial for the heartand brain health: they lower blood pressure and heart rate, improve blood vessel function, reducetriglycerides and system inflammation. They are good for eye health and skin appearance. Scientific studiesshow that omega-3s can help fight depression and improve attention. Along with omega-3 fats, omega-6fats play a crucial role in brain function, and normal growth and development. Omega-6s help stimulate skinand hair growth, maintain bone health, regulate metabolism, and maintain the reproductive system. Severallarge-scale studies identified genetic variations in and near the FADS enzymes that interfere with metabolismof omega-3 and omega-6 fats. While both omega-3 and omega-6 fatty acids are essential for human body, ahealthy diet should contain an equal ratio of omega-6 to omega-3. The main problem with a typical Westerndiet is that it contains way too many Omega-6s relative to Omega-3s.

POLYUNSATURATEDFATSINCREASEDBENEFITS

YOU:

70SLIGHTLY

ADVANTAGED


WHATTODO

You have genetic variations in or near the FADS enzymes that play key roles in fatty acid metabolism,thereby requiring additional sources of omega-3 and omega-6 in your diet.

While both omega 3 and omega6 fatty acids are essential, the goal is to increase the intake ofomega-3 fats while limiting the intake of omega-6 fats (from fried and processed foods).Aim to eat fish high in DHA and EPA omega-3 fatty acids two to three times a week.These include anchovies, herring mackerel, salmon (wild has more omega-3s than farmed), sardines,lake trout, tuna. Walnuts and flaxseed have omega-3s and 6s too.Talk to your doctor or registered dietitian about optimizing your dietary intake of omega 3 and 6 fattyacids. Getting professional advice is particularly important if you are taking medications.

NATUREVS.NURTURE


GENETICVARIATIONS



rs174548, rs3134950, rs10761785, rs174550, rs174546, rs174547, rs174537











SUMMARY

You have risk alleles that were found to put you under slightly higher risk for increased triglycerides,cholesterol, and extra weight, if you consume saturated fats. Watch for saturated fats in your diet.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Risk From Saturated Fats1 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 70% of the population and is consideredstatistically risky compared to the general population.

WHATISRISKFROMSATURATEDFATS

It is no secret that large amounts of saturated fats are not good for anyone. People with genetic variations inthe FABP and APOA2 genes were found to be under higher risk of elevated triglycerides, elevatedcholesterol and extra weight.

WHATTODO


NATUREVS.NURTURE


RISKFROMSATURATEDFATS

YOU:

70SLIGHTLYELEVATED


GENETICVARIATIONS



rs1799883





SUMMARY


MYASSESMENT




WHATTODO


SATIETYIMPAIRMENT

YOU:

65SLIGHTLYELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs1137101, rs9939609, rs992472







SUMMARY


MYASSESMENT




WHATTODO


SLOWMUSCLEREPAIR

YOU:

90ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS















SUMMARY

You do not seem to have genetic-driven impulse for frequent snacking.Keep a healthy diet and exercise as appropriate for your age group.Try to eat healthy snacks such as baby carrots and celeries rather than chips and salsa!

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Snacking1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 50% of the population and is consideredstatistically low compared to the general population.

WHATISSNACKING

Some people feel hungry more often than others and are impulsively driven to frequent snacking, which if leftunchecked can result in extra weight. Variations in the MC4R, leptin receptor (LEPR), NMB and BDNF genes,have been linked to increased snacking. Genetic variations in the MC4R gene are also significantlyassociated with higher BMI and obesity.

WHATTODO

You do not seem to have genetic-driven impulse for frequent snacking.Keep a healthy diet and exercise as appropriate for your age group.Try to eat healthy snacks such as baby carrots and celeries rather than chips and salsa!A good goal for a between-meal snack is something with fewer than 100 calories. Generous portionsof fruits or vegetables can easily help fill you up while staying below that calorie count.

SNACKING

YOU:

50NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs17782313





SUMMARY

Your ability to metabolize starch-rich diet is typicalStarchy foods often need to be limited if you're following a low-carb diet.However, the U.S. Department of Agriculture recommends you fill one-fourth of your plate with thesefoods at each meal since they provide essential nutrients.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Starch Metabolism2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISSTARCHMETABOLISM

Starch is a complex carbohydrate. Foods high in starch include grains (oats, barley, rice), and starchyvegetables (potatoes, beans, corn, lentils). Starch is metabolized by a digestive enzyme, called amylase. Insome people, amylase can account for up to half of total protein in the saliva, while other people have barelydetectable levels of this enzyme. Large variation in levels of amylase depends on various factors, includingstress, as well as genetics. Interestingly, populations who historically relied on starch (rice, potato) for dietaryenergy have higher levels of the amylase than populations who consumed high-protein diets. People withhigh levels of amylase were found to be good metabolizers of starch-rich diet, while people with low levels ofamylase enzyme are poor metabolizers of starch, and they may be at greater risk for increased bloodglucose levels, insulin resistance and diabetes if they consume starch-rich diets.

STARCHMETABOLISM

YOU:

10NORMAL


WHATTODO

Your ability to metabolize starch-rich diet is typicalStarchy foods often need to be limited if you're following a low-carb diet.However, the U.S. Department of Agriculture recommends you fill one-fourth of your plate with thesefoods at each meal since they provide essential nutrients.Your body needs 5 to 8 ounces per day from the breads and grains group, depending on your ageand activity level, at least half of which should come from whole grains. A slice of bread, one-halfcup of oatmeal or rice, a mini bagel, a cup of dry cereal and 3 cups of popcorn are all equivalent to 1ounce.You should also consume 4 to 6 cups of starchy vegetables and 1 to 2 cups of beans each week asa part of your daily recommended intake of 2 to 3 cups of vegetables.

NATUREVS.NURTURE


GENETICVARIATIONS

There are 2 genes within your DNA that influence this trait.You have No contributing and 2 inhibiting genes that affect this trait.




rs1930212, rs6696797




SUMMARY

While you may crave sugars and sugary foods and drinks but this is more likely to be an acquiredtaste rather than genetically influenced.It is very important to monitor your sugar intake. If you are serious about controlling your sugarcravings, it may be easier for you to do than you think.Aim at getting your sugar craving naturally. Avoid processed foods, read the labels, do not gohungry, and make sure your blood sugar is stable.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Sweet Tooth1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISSWEETTOOTH

A person with a sweet tooth has a higher sugar craving than the average person. If a person has a highsweet tooth predisposition, it is likely that they will often crave sweets and snack on sugary foods. Geneticvariations in TAS1R2, GLUT2, FUT1, may be responsible for sugar cravings, and preference of sweetsnacks. This may lead to weight gain, elevated glucose levels as well as pose future threats of Type-IIdiabetes, in particular in people with predispositions to these conditions. Remember, it is recommended thathealthy adults may consume of added sugars up to to 150 calories per day (37.5 grams or 9 teaspoons) formen, and 100 calories per day (25 grams or 6 teaspoons) for women.

WHATTODO

While you may crave sugars and sugary foods and drinks but this is more likely to be an acquired tasterather than genetically influenced.

It is very important to monitor your sugar intake. If you are serious about controlling your sugarcravings, it may be easier for you to do than you think.Aim at getting your sugar craving naturally. Avoid processed foods, read the labels, do not gohungry, and make sure your blood sugar is stable.Eat more greens, fermented foods and sea vegetables.Finally. drink plenty of water, exercise, and be outdoors.

SWEETTOOTH

YOU:

30NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs3935570





SUMMARY

You need to minimize intake of trans fats, in particular those that are contained in processed food.The American Heart Associations recommends to limit the amount of trans fats to less than 1percent of your total daily calories.Look for 0 g trans fat on the Nutrition Facts label and no hydrogenated oils in the ingredients list.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Trans Fats Sensitivity11 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 60% of the population and is consideredstatistically risky compared to the general population.

WHATISTRANSFATSSENSITIVITY

Trans fatty acids (trans fats) cannot be synthesized by humans. Trans fats are considered the worst type offat you can eat. Trans fats are of two types: natural and artificial. Natural trans fats can be found in smallquantities in dairy and meat products. Artificial trans fats are created in an industrial process that addshydrogen to liquid vegetable oils, producing partially hydrogenated oils. Trans fats are linked to adversehealth outcomes: they raise bad cholesterol levels (LDL) and lower good cholesterol levels (HDL), increaserisk of developing heart diseases and type 2 diabetes. It is common knowledge that trans-fats are nothealthy. People with genetic variants in or near the fatty acid desaturase (FADS1 and 2) cluster are moresensitive to adverse effects of trans fats.

WHATTODO


TRANSFATSSENSITIVITY

YOU:

60SLIGHTLYELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs174548, rs174549, rs102275, rs174576, rs1535, rs174550, rs174556, rs174546, rs174547,rs174534, rs174537















Explore the genes that contribute to allergies from indoor to outdoor, food and more using our proprietaryAI-enhanced genomics analysis.

AllergyReports24 Reports in 5 groups

FoodAllergiesThe bodyâ€™s immune system keeps you healthy by fighting off infections and otherdangers to good health. A food allergy reaction occurs when your immune systemoverreacts to a food or a substance in a food, identifying it as a danger and triggering aprotective response. Food allergy symptoms are most common in babies and children,but they can appear at any age. You can even develop an allergy to foods you haveeaten for years with no problems. Learn more about your potential geneticpredispositions for various food allergies.

IndoorAllergiesMillions of people suffer year-round from allergy symptoms caused by indoor allergens.Although many substances in dust can trigger allergic symptoms, the most importantindoor allergens are dust mites, pet dander, cockroaches, and molds. Unlike seasonalallergies such as hay fever, indoor allergies may last all year long. Explore how yourgenetics may predispose or protect you in the face of indoor allergens in this section.

OutdoorAllergiesThe most common sources of outdoor allergens are pollen, and include: Tree pollen,which are most common in the spring. Grass pollen, which are most common in thesummer. Weed pollen, which are most common in the summer and fall. Ragweed pollenin particular is the most common cause of fall allergy symptoms. Explore yourpredisposition to and protection from common outdoor allergens in this section.

SensitivitytoChemicalsWhether or not your body is sensitive to chemicals such as solvents and volatile organiccompounds is influenced by your genetics. Chemical sensitivity can be triggered bytoxic waste sites, basements, ventilation systems, industrial emissions, mold, bacteria,golfing (pesticides), painting, plastics, dentures, hearing aids--even jewelry. Explore yourgenetic predispositions for sensitivity to chemicals in this section.


OtherSensitivitiesIn addition to food, outdoor, indoor and chemical allergies and sensitivities, your geneticmakeup can also influence other sensitivities that impact your life. Explore how yourunique genetic makeup impacts your potential predisposition for motion sickness, painsensitivity, seasonality, noise sensitivity, and noise-induced hearing loss in this section.


SUMMARY

Minimize your exposure to these unsightly pests, crawling across your kitchen floor in the middle ofthe nightFix leaky pipes under the sinks and in the basement, seal cracks in the wallsStore food in airtight containers, keep tables and floors free from crumbs, cover trash cans

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Allergy To CockroachesNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically low compared to the general population.

WHATISALLERGYTOCOCKROACHES

Cockroaches live in many locations around the world, in all types of buildings and all kinds ofneighborhoods. The National Pest Management Association reports that over 60 percent of homes in theUnited States contain cockroach allergens. This number rises to 80-90 percent in urban areas. The saliva,feces and shedding body parts of cockroaches contain a protein that can trigger allergies and even asthmain some people. A cockroach allergy is a trigger of year-round allergy and asthma. Common cockroachallergy symptoms include runny stuffy or itchy nose, itchy or red eyes, skin rash, cough, mucus. People withsome genetic variations have higher risk of developing allergies to cockroaches.

WHATTODO

Minimize your exposure to these unsightly pests, crawling across your kitchen floor in the middle of the nightFix leaky pipes under the sinks and in the basement, seal cracks in the wallsStore food in airtight containers, keep tables and floors free from crumbs, cover trash cansUse cockroach baits and trapsMinimize the use of sprays as they can irritate allergies and trigger asthma.

ALLERGYTOCOCKROACHES

YOU:

5NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Allergy To Cockroaches by checking out the following articles:

Cockroach Allergy Cockroach Allergy and Asthma Attacks

GENETICVARIATIONS






http://acaai.org/allergies/types/cockroach-allergies

http://www.aafa.org/page/cockroach-allergy.aspx


SUMMARY

If you have year round allergy-like symptoms, dust mites are likely to blameEven if you do not have these symptoms, take steps to reduce your exposure to dustIn your bedroom, encase mattresses in dust mite-proof covers; use pillows with synthetic fillings

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Allergy To Dust Mites9 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 75% of the population and is consideredstatistically risky compared to the general population.

WHATISALLERGYTODUSTMITES

Dust mites are microscopic creatures, related to ticks and spiders that live in house dust. The proteins indust mite body parts and feces cause allergic reactions in some people. Dust allergy symptoms are similar tothose of pollen allergies and include red, itchy, watery eyes, runny, itchy, stuffy nose, sneezing. Thesesymptoms persist all year round and feel like endless cold or even asthma. It is estimated that up to 20million Americans have dust mite allergy. When inhaled, dust mite allergen triggers asthma attacks and isone of the most common causes of asthma attacks worldwide. This is primarily because dust mites arefound nearly everywhere, especially indoors. All homes contain some amount of dust mites. Because dustmites feed on dead human skin, the allergen tends to be concentrated in mattresses, bedding, upholsteredfurniture, carpets. Pets contribute dander to the dust and increase the food source for mites. Several geneticvariations have been found to be associated with increased risk of allergy to dust-mites.

ALLERGYTODUSTMITES

YOU:

75SLIGHTLYELEVATED


WHATTODO

If you have year round allergy-like symptoms, dust mites are likely to blameEven if you do not have these symptoms, take steps to reduce your exposure to dustIn your bedroom, encase mattresses in dust mite-proof covers; use pillows with synthetic fillingsWash your bedding in very hot water every week; Avoid steam-cleaning bedding, upholstery andcurtains: increased humidity fosters future mite growthUse natural fiber rugs that can be cleaned easily or better have hardwood, tile or linoleum flooringUse a vacuum cleaner with HEPA (high-efficiency particulate air) filter. Invest in the HEPA air purifierto remove allergens.Keep air in your house cool and cleanPut the stuffed toys in the freezer to kill the dust mites. If you have pets, bathe them often.

NATUREVS.NURTURE


GENETICVARIATIONS





rs10174949











SUMMARY

While you do not seem to have known genetic risks for egg allergy, genetics is only part of theequation.If you experience skin inflammation, nasal congestion, runny nose, cramps, nausea, coughing,wheezing, chest tightness or shortness of breath after consuming egg products, you may want toconsult your doctor.Most people with egg allergies react to the egg whites, not the yolk. If you suspect you have areaction to egg, consider making an appointment with the doctor for diagnostic test.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Allergy To EggsNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically low compared to the general population.

WHATISALLERGYTOEGGS

The body immune system may see the egg protein as a foreign invader and attack it causing allergicreaction. Egg allergy symptoms usually occur a few minutes to a few hours after eating eggs or foodscontaining eggs, or even touching eggs for some people. Symptoms vary from mild to severe and caninclude skin rashes, hives, nasal congestion, and vomiting or other digestive problems. Eggs are one of themost common allergy-causing foods for children. Experts estimate that as many as 2 percent of children areallergic to eggs. Fortunately, studies show that about 70 percent of children with an egg allergy will outgrowthe condition by age 16. People with an allergy to chicken eggs may also be allergic to other types of eggs,such as goose, duck, turkey or quail.

Several genetic variations are associated with increased risk of egg allergy. Just like with other allergies,genetics is only part of the equation. The rates of allergy are increasing throughout the world, affecting up to30-35% of people at some stage in their lives. Factors such as general health, immune system functioning,as well as other rare and yet unknown genetic and epigenetic mechanisms, have significant contributionstoo.

ALLERGYTOEGGS

YOU:

25NORMAL


WHATTODO

While you do not seem to have known genetic risks for egg allergy, genetics is only part of the equation.If you experience skin inflammation, nasal congestion, runny nose, cramps, nausea, coughing,wheezing, chest tightness or shortness of breath after consuming egg products, you may want toconsult your doctor.Most people with egg allergies react to the egg whites, not the yolk. If you suspect you have areaction to egg, consider making an appointment with the doctor for diagnostic test.

NATUREVS.NURTURE


LEARNMORE

Learn more about Allergy To Eggs by checking out the following articles:

Egg Allergy: Definition Tips to Manage Your Egg Allergy Tips to Manage Your Egg Allergy

GENETICVARIATIONS






http://www.mayoclinic.org/diseases-conditions/egg-allergy/basics/definition/con-20032721

http://www.webmd.com/allergies/guide/egg-allergy

http://www.webmd.com/allergies/guide/egg-allergy


SUMMARY

You do not seem to have known genetic risks for milk allergy, but genetics is only part of theequation when it comes to milk allergy. Factors such as general health, immune system functioning,as well as other rare and yet unknown genetic and epigenetic mechanisms, have significantcontributions too.Check your lactose intolerance trait within this section as well. These two allergies have differentmechanisms within the body. If you only get affected by milk and not by other dairy products thatconatin lactose, you may have sensitivity to milk. If you are affected by some of the symptoms mentioned above after consuming milk products, doconsider making an appointment with your allergist for a diagnostic test.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Allergy To Milk2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISALLERGYTOMILK

Milk allergy symptoms (different from lactose intolerance) occur a few minutes to a few hours after drinkingmilk or eating milk products. Immediately after consuming milk, signs and symptoms of a milk allergy mightinclude: hives, wheezing, vomiting. Signs and symptoms that may take more time to develop include: loosestools, which may contain blood, diarrhea, abdominal cramps, coughing or wheezing, runny nose, wateryeyes, itchy skin rash, often around the mouth, and colic, in babies. Approximately 2.5 percent of childrenyounger than three years of age are allergic to milk but over 80% of them outgrow it. Milk allergy differs fromlactose intolerance. Unlike a milk allergy, lactose intolerance does not involve the immune system. However,they have common digestive symptoms, such as bloating, gas or diarrhea, after consuming milk and dairyproducts. Genetic variations associated with milk allergy have recently been identified in a large study.

ALLERGYTOMILK

YOU:

30NORMAL


WHATTODO

You do not seem to have known genetic risks for milk allergy, but genetics is only part of the equation whenit comes to milk allergy. Factors such as general health, immune system functioning, as well as other rareand yet unknown genetic and epigenetic mechanisms, have significant contributions too.

Check your lactose intolerance trait within this section as well. These two allergies have differentmechanisms within the body. If you only get affected by milk and not by other dairy products thatconatin lactose, you may have sensitivity to milk. If you are affected by some of the symptoms mentioned above after consuming milk products, doconsider making an appointment with your allergist for a diagnostic test.

NATUREVS.NURTURE


LEARNMORE

Learn more about Allergy To Milk by checking out the following articles:

Milk Allergy: Symptoms, Manahmnet and Treatment Differences between Milk Allergy and Lactose Intolerance

GENETICVARIATIONS



rs1800872, rs1800896



http://acaai.org/allergies/types-allergies/food-allergy/types-food-allergy/milk-dairy-allergy

http://www.foodallergy.org/allergens/milk-allergy




SUMMARY

Take basic steps to reduce the mold in your houseIt is important to keep your house dry: molds thrive in moist conditionsDo not use carpets in bathrooms and basement

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Allergy To MoldNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISALLERGYTOMOLD

Mold are fungi that thrive both outside (in logs, fallen leaves, compost piles, grasses) and inside (in moistplaces like bathroom, kitchen, basement). There are many different types of mold, some are visible by eye,others are not. Molds make spores that float in the air like pollen. But unlike plants that produce pollen, molddo not die with the first frost. They simply slow down or stop growing during this time and they start growingin the spring. Some people are allergic to molds: when they inhale the spores they develop typical allergysymptoms. Genetic variations associated with allergies to two types of mold fungus (Cladosporium andAlternaria) have been identified.

WHATTODO

Take basic steps to reduce the mold in your houseIt is important to keep your house dry: molds thrive in moist conditionsDo not use carpets in bathrooms and basementFix water leaksClean the garbage often and de-clutter (mold can grow in piles of old newspapers and clothing)

ALLERGYTOMOLD

YOU:

30NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Allergy To Mold by checking out the following articles:

10 Ways to Reduce Mold Allergies Mold Allergy: Overview Allergies to Cladosporium

GENETICVARIATIONS






http://www.webmd.com/allergies/ss/ways-to-reduce-mold-allergies-slideshow

http://acaai.org/allergies/types/mold-allergy

http://www.livestrong.com/article/250194-allergies-to-cladosporium/


SUMMARY

You do not seem to have a genetic risk for peanut allergies, and in fact only 2% people suffer fromactual peanut allergy.However, genetics is only part of the equation when it comes to allergies. In addition to the better known symptoms such as shortness of breath or wheezing and redness orswelling of your skin, individuals with peanut allergies may show milder symptoms such as Itching ortingling in or around the mouth and throat or digestive problems, such as diarrhea, stomach cramps,or nausea. If you experience any of these, try to minimize your contact with nut products to see if thesymptoms subside.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Allergy To Peanuts3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 75% of the population and is consideredstatistically low compared to the general population.

WHATISALLERGYTOPEANUTS

Peanut allergy is one of the most common food allergies. In the U.S., approximately three million peoplereport allergies to peanuts and tree nuts. Peanut allergies may be triggered by even the slightest exposureand they are difficult to manage because peanut is used in a variety of food products. Symptoms of peanutallergy vary from a slightly itchy mouth or tingling sensation in or around the mouth or throat after eatingpeanuts to nausea and runny or congested nose to less common anaphylaxis, which is potentially life-threatening reaction that impairs breathing and can send the body into shock.

Based on recent studies, an estimated 25-40 percent of people who have peanut allergy also are allergic totree nuts. In addition, peanuts and tree nuts often come into contact with one another during manufacturingand serving processes. For these reasons, allergists usually tell their patients with peanut allergy to avoidtree nuts as well. Research by the National Institutes of Health shows that about 20% of children with apeanut allergy outgrow it. Researchers estimated that genetics may account for up to 80% of peanutallergies.

ALLERGYTOPEANUTS

YOU:

75NORMAL


WHATTODO

You do not seem to have a genetic risk for peanut allergies, and in fact only 2% people suffer from actualpeanut allergy.

However, genetics is only part of the equation when it comes to allergies. In addition to the better known symptoms such as shortness of breath or wheezing and redness orswelling of your skin, individuals with peanut allergies may show milder symptoms such as Itching ortingling in or around the mouth and throat or digestive problems, such as diarrhea, stomach cramps,or nausea. If you experience any of these, try to minimize your contact with nut products to see if thesymptoms subside. People with impaired skin barrier function caused by mutations in the filaggrin gene have higher riskto allergies, including peanut allergy (check you skin barrier sensitivity report in the Skin Carepackage).If you suspect you have allergic reaction to peanuts (or other nuts), see an allergist for diagnosis andtreatment. Diagnosing a peanut allergy can be complicated. Symptoms can vary from person toperson, and a single individual may not always experience the same symptoms during everyreaction. Your allergist will work with you to determine the best ways to manage your symptoms.

NATUREVS.NURTURE


LEARNMORE

Learn more about Allergy To Peanuts by checking out the following articles:

Peanut Allergy: Mayo Clinic Definition Avoiding Peanuts Peanut Allergy:Symptoms, Management and Treatment

http://www.mayoclinic.org/diseases-conditions/peanut-allergy/basics/definition/con-20027898

https://www.foodallergy.org/allergens/peanut-allergy

http://acaai.org/allergies/types/food-allergies/types-food-allergy/peanut-allergy


GENETICVARIATIONS



rs10878354, rs9275596, rs4584173







SUMMARY

You do not seem to have a genetic risk for pet allergy, but remember genetics is only part of theequation when it comes to allergiesWatch out for symptoms of pet allergy: coughing and wheezing, red, itchy eyes, runny, itchy stuffynose, sneezing, and skin reactions after being in contact with a pet

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Allergy To Pets2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 70% of the population and is consideredstatistically low compared to the general population.

WHATISALLERGYTOPETS

Pet allergy is an allergic reaction to proteins found in an animals skin cells, saliva or urine. Signs of petallergy include those common to hay fever, such as sneezing and runny nose. Some people may alsoexperience signs of asthma, such as wheezing and difficulty breathing. Most often, pet allergy is triggered byexposure to the dead flakes of skin (dander) a pet sheds. Any animal with fur can be a source of pet allergy,but pet allergies are most commonly associated with cats, dogs (as well as horses and rats). For a personwith pet allergies, life in a dog-loving country is not easy. In 2012, over a third of the U.S. households had adog. Dog dander gets everywhere, including places where dogs have never set a paw. According to theNational Institutes of Health, detectable levels of pet dander are in every home in the U.S. Genetic variationsin some genes have been identified to be associated with allergy to pets.

WHATTODO

You do not seem to have a genetic risk for pet allergy, but remember genetics is only part of the equationwhen it comes to allergies

Watch out for symptoms of pet allergy: coughing and wheezing, red, itchy eyes, runny, itchy stuffynose, sneezing, and skin reactions after being in contact with a pet

ALLERGYTOPETS

YOU:

70NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Allergy To Pets by checking out the following articles:

Everything about Dog Allergies Pet Allergy Overview

GENETICVARIATIONS



rs4833095, rs2155219



http://www.webmd.com/allergies/guide/dog-allergies

http://www.aaaai.org/conditions-and-treatments/allergies/pet-allergy.aspx




SUMMARY

If you have hay fever symptoms, birch pollen may be one of the reasonsWatch out for the symptoms of allergy to birch pollen and try to avoid areas with high birch pollenconcentrationMany weather websites provide a pollen index, which you may want to consult as a safetyprecaution

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Birch Pollen AllergyResistance1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 40% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISBIRCHPOLLENALLERGYRESISTANCE

Some people have genetic variations that make them more resistant towards birch pollen allergy. In otherwords, people with this genetic variations have lower incidents of allergies to birch (Betulaceae). Birch pollenis very allergenic pollen and is one of the main triggers of hay fever. In allergic people it can also cause anasthma attack, conjunctivitis, and oral allergy syndrome that causes an itchy mouth after eating raw fruits,vegetables, or nuts. Birch pollen cross-reacts with many fruits, vegetables and nuts, with apples being themost common cross-reaction associated with birch pollen.

BIRCHPOLLENALLERGYRESISTANCE

YOU:

40TYPICAL


WHATTODO

If you have hay fever symptoms, birch pollen may be one of the reasonsWatch out for the symptoms of allergy to birch pollen and try to avoid areas with high birch pollenconcentrationMany weather websites provide a pollen index, which you may want to consult as a safetyprecautionOne of the potential issues with birch pollen allergy is that it cross-reacts with foods causing an oralallergy syndrome in people allergic to itIf you experience itchiness or swelling of the mouth, face, lip after eating raw fruits (apple, apricot,peach, plum, cherry, kiwi), vegetables (carrot, celery, fennel, coriander, parsley), nuts (almonds,hazelnut), take over the counter medicine or talk to your health-care provider

NATUREVS.NURTURE


LEARNMORE

Learn more about Birch Pollen Allergy Resistance by checking out the following articles:

Birch Pollen Allergy: List of Foods to Avoid or Limit Oral Allergy Syndrome (OAS) Birch pollen allergy, seasonal allergies

GENETICVARIATIONS



rs887864



http://www.healwithfood.org/allergicrhinitis/birch-pollen-foods-avoid-list.php

https://www.aaaai.org/conditions-and-treatments/library/allergy-library/outdoor-allergies-and-food-allergies-can-be-relate

https://avantgardemedical.ca/en/allergies-treatment/conditions/birch-pollen-allergy-treatment/



SUMMARY

You are less likely to experience bitter taste sensitivity when consuming vegetables.Continue to eat a variety of vegetables to meet your daily needs.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Bitter Taste Sensitivity1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISBITTERTASTESENSITIVITY

Taste perception plays a fundamental role in our dietary preferences and behaviors, by shaping aversions (orcravings) to foods and drinks. Adverse responses to bitterness are instinctive and drive rejection andavoidance behaviors. The perception of bitterness is due to genetic variations in several bitter tastereceptors: when food enters the mouth, the molecules, like phenylthiocarbamide (PTC) compound, interactwith saliva, and then bind to taste receptors in the mouth, giving the sensation of bitter taste. People withthese genetic variations are sensitive to bitter vegetables that are beneficial (like broccoli, Brussel sprouts,cabbage) or drinks (like coffee and dark beers). There is a growing evidence that taste genes play a muchbroader role in human health. A new study found that people who are naturally more sensitive to bitternessare more likely to add sodium to their food, often exceeding recommended daily dietary guidelines. At thesame time, these people are more likely to avoid ingredients that are beneficial for health, including darkleafy greens and broccoli.

WHATTODO

You are less likely to experience bitter taste sensitivity when consuming vegetables.Continue to eat a variety of vegetables to meet your daily needs.

BITTERTASTESENSITIVITY

YOU:

30NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Bitter Taste Sensitivity by checking out the following articles:

From Kale To Pale Ale, A Love Of Bitter May Be In Your Genes PTC The Genetics of Bitter Taste

GENETICVARIATIONS



rs978739



http://www.npr.org/sections/thesalt/2014/10/01/352771618/from-kale-to-pale-ale-a-love-of-bitter-may-be-in-your-genes

http://learn.genetics.utah.edu/content/basics/ptc/



SUMMARY

You may need to boost your body's production of glutathione by consuming the following foodsources: beef, pork, poultry, fish, cheese, tofu, legumes. These foods are high in essential aminoacids that provide building blocks for producing glutathione.Studies showed that the expression and activity of GSTT1and GSTM1 genes coding for glutathionecan be induced by the consumption of cruciferous vegetables (cauliflower, cabbage, garden cress,bok choy, broccoli, Brussels sprouts).Regular exercise boosts glutathione production, however athletic over-training may result in lowerglutathione.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Glutathione Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically risky compared to the general population.

WHATISGLUTATHIONEDEFICIENCY

Glutathione is a powerful antioxidant that is produced naturally by the liver. It is involved in tissue building,immune response, nutrient metabolism, and regulation of cellular events, including cell proliferation andapoptosis. Glutathione is often called the master antioxidant as it scavenges free radicals, peroxides, lipidperoxides and heavy metals. Glutathione is required for proper utilization and functioning of otherantioxidants such as vitamins C, E, selenium and carotenoids. Glutathione deficiency contributes tooxidative stress, which plays a key role in aging and the age-related diseases. Genetic variations (anddeletions) in genes (GPX1 GSTP1 GSTT1 GSTM1) lead to lower production and activity of glutathionecompromising its detoxification capacity. There is a growing scientific evidence that glutathione helps controlinflammation, fight infections, and boost immune system. It has been used to treat acne and as a skinlightening agent. Glutathione occurs naturally in many foods but its absorption from fruits and vegetablesmay be low. Adequate amounts of protein increases the production of glutathione in our bodies.

GLUTATHIONEDEFICIENCY

YOU:

65SLIGHTLYELEVATED


WHATTODO

You may need to boost your body's production of glutathione by consuming the following food sources:beef, pork, poultry, fish, cheese, tofu, legumes. These foods are high in essential amino acids that providebuilding blocks for producing glutathione.

Studies showed that the expression and activity of GSTT1and GSTM1 genes coding for glutathionecan be induced by the consumption of cruciferous vegetables (cauliflower, cabbage, garden cress,bok choy, broccoli, Brussels sprouts).Regular exercise boosts glutathione production, however athletic over-training may result in lowerglutathione.The use of intravenous glutathione injections is becoming popular, albeit controversial. Glutathione supplements are readily available but as always discuss it with your healthcare provider.

NATUREVS.NURTURE


LEARNMORE

Learn more about Glutathione Deficiency by checking out the following articles:

Glutathione Injection Symptoms and Side Effects Glutathione metabolism and its implications for health. Find a Vitamin or Supplement Benefits of Glutathione

GENETICVARIATIONS



rs74837985, rs7483, rs113846795



http://www.livestrong.com/article/442372-glutathione-injection-symptoms-and-side-effects/

http://www.ncbi.nlm.nih.gov/pubmed/14988435

http://www.webmd.com/vitamins-supplements/ingredientmono-717-glutathione.aspx

http://www.livestrong.com/article/93734-benefits-glutathione/





SUMMARY

You do not seem to have known genetic predispositions to gluten sensitivity, but if you see some ofthe above mentioned symptoms in your daily life, you may want to pay attention to gluten in yourfood.Take the following glutensensitivityself-assessmentquiz (third party website, opens in a newwindow) to get some more insights.Another way to explore whether you would benefit from a gluten-free diet is to try it out and see ifpotential symptoms disappear.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Gluten Sensitivity1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 55% of the population and is consideredstatistically low compared to the general population.

WHATISGLUTENSENSITIVITY

Gluten is a protein found primarily in grains (wheat, rye, barley). Gluten sensitivity may affect up to 6 percentof the population. It is sometimes called non-celiac gluten sensitivity to distinguish it from celiac disease,which is an autoimmune condition. After eating foods with gluten, people with gluten sensitivity canexperience abdominal pain, diarrhea or constipation, and bloating. People sensitive to gluten can alsoexperience other symptoms, such as fatigue, headaches, and joint pain. According to a recent survey, morethan 30% of Americans actively try to avoid eating gluten. However, it is unclear whether this is warranted. Arecent study found that among 400 individuals who thought they were gluten intolerant, only 55 people(14.5%) actually had an issue with gluten. In some cases, people who eliminate gluten may end up gainingweight because these foods often have more calories than their gluten-containing counterparts.

Symptoms of Gluten Sensitivity include:

Digestive issues such as gas, bloating, diarrhea and even constipation.Fatigue, brain fog or feeling tired after eating a meal that contains gluten. Migraine headaches.Joint inflammationAnxiety, depression, mood swings and ADD.

GLUTENSENSITIVITY

YOU:

55NORMAL

http://www.stuffed-pepper.com/am-i-gluten-sensitive-take-the-gluten-sensitivity-self-test/


Of course any of these symptoms in and of themselves are not a sufficient reason to suspect glutensensitivity or intolerance. Several genetic variations were found more frequently in people with glutensensitivity.

WHATTODO

You do not seem to have known genetic predispositions to gluten sensitivity, but if you see some of theabove mentioned symptoms in your daily life, you may want to pay attention to gluten in your food.

Take the following glutensensitivityself-assessmentquiz (third party website, opens in a newwindow) to get some more insights.Another way to explore whether you would benefit from a gluten-free diet is to try it out and see ifpotential symptoms disappear.Foods that are naturally gluten-free include:Fruits, Vegetables, Meat and poultry, Fish and seafood,Dairy, Beans, legumes, and nuts, rice, corn, soy, potato, beans, quinoaAs always check with your doctor before making any abrupt changes to your diet.

NATUREVS.NURTURE


LEARNMORE

Learn more about Gluten Sensitivity by checking out the following articles:

Celiac disease â€“ Genetic testing and clinical utility Low Gluten Diet Against the Grain


http://eurogene.blogspot.com/2010/02/celiac-disease-genetic-testing-and.html

http://www.livestrong.com/article/421992-low-gluten-diet/

http://www.newyorker.com/magazine/2014/11/03/grain


GENETICVARIATIONS



rs2305764





SUMMARY

You do not seem to have genetic resistance against grass allergy. This does not mean you are moreprone for grass allergy, it just means you are not among those individuals that have a much lowerlikelihood for contracting grass allergy. If you do experience hay fever, do watch out for allergic reactions to grass as a potential root causeif you experience hay fever. You don't always need a genetic advantage to reduce your likelihood for allergies. Research hasshown that high levels of stress can worsen existing allergies, possibly by upsetting the balance ofsubstances in your body that control immune response. Try to meditate often to keep your immunesystem strong and keep your stress levels from exacerbating potential allergies.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Grass Allergy Resistance2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 60% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISGRASSALLERGYRESISTANCE

Grass pollen is known to cause a variety of different allergic reactions. Grass pollen is most present in the airduring the late spring and early summer months, and can cause allergic rhinitis, allergic conjunctivitis, andasthma. Direct skin contact with grass, from sitting in the grass or mowing the lawn, can cause itching,urticaria (also known as hives), and atopic dermatitis (eczema). Grass allergy can also be associated withfruit pollen syndrome resulting in food allergies to tomatoes, potatoes, and peaches.

A recent study identified genetic variations associated with lower incidents of grass allergy. This implies thatthese genetic variations are protective from grass allergies, and people who have these variations are lesslikely to develop allergies to poacea. True grasses (poaceae) are a family of plants to which a large part ofthe population is allergic. These plants are characterized by long and narrow cuts. Cultivated cereals such aswheat, oats, corn, rice are among the many true grasses species.

GRASSALLERGYRESISTANCE

YOU:

60TYPICAL


WHATTODO

You do not seem to have genetic resistance against grass allergy. This does not mean you are more pronefor grass allergy, it just means you are not among those individuals that have a much lower likelihood forcontracting grass allergy.

If you do experience hay fever, do watch out for allergic reactions to grass as a potential root causeif you experience hay fever. You don't always need a genetic advantage to reduce your likelihood for allergies. Research hasshown that high levels of stress can worsen existing allergies, possibly by upsetting the balance ofsubstances in your body that control immune response. Try to meditate often to keep your immunesystem strong and keep your stress levels from exacerbating potential allergies.

NATUREVS.NURTURE


LEARNMORE

Learn more about Grass Allergy Resistance by checking out the following articles:

How to Avoid Allergy to Poaceae Grasses, the main triggers of hay fever

GENETICVARIATIONS



rs631208, rs6554809



http://health.onehowto.com/article/how-to-avoid-allergy-to-poaceae-3262.html

http://www.aha.ch/swiss-allergy-centre/info-on-allergies/-allergies-intolerances/pollen-allergy/grasses/




SUMMARY

It's very difficult to completely avoid pollen.Even if you do not experience hay fever symptoms, you may want to follow common sense steps tominimize the effect of pollen on your well-being.Pay attention to pollen counts in your area.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Hay Fever20 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISHAYFEVER

Many different substances and pollen cause the allergic symptoms commonly called hay fever. While hay isnot the only allergen that causes problems and it does not cause fever, this popular name appeared fromearly descriptions of sneezing, nasal congestion, and eye irritation while harvesting hay fields. The scientificterm for it is allergic rhinitis that originates from rhino (nose). At peak seasons hay fever affects up to 30% ofall people worldwide. Symptoms of hay fever often mimic those of chronic colds, and include nasalcongestion, a runny nose with clear mucus, sneezing, nose, eye itching, excess tears. Hay fever can makeyou feel miserable, and generally interfere with your daily life affecting your performance at work or school.Large genome-wide association studies identified multiple genetic markers associated with hay fever.

HAYFEVER

YOU:

95ELEVATED


WHATTODO

It's very difficult to completely avoid pollen.Even if you do not experience hay fever symptoms, you may want to follow common sense steps tominimize the effect of pollen on your well-being.Pay attention to pollen counts in your area.In the high pollen season, these steps include washing bed sheets weekly in hot water, always batheand wash hair before bedtime (pollen can collect on skin and hair throughout the day).Avoid cutting grass, and walking in grassy areas in the early morning, evening and at night, when thepollen count is at its highest.Keep car windows closed and get a pollen filter for the air vents in your car.Take over the counter medicine to get relief from hay fever symptoms.See a doctor if allergy medications to do provide relief or cause annoying side effects, and if youhave another condition that can worsen hay fever symptoms, such as nasal polyps, asthma orfrequent sinus infections.

NATUREVS.NURTURE


LEARNMORE

Learn more about Hay Fever by checking out the following articles:

10 Ways to Manage Your Hay Fever Symptoms Hay Fever Conditions Hay fever - Prevention

http://www.medicinenet.com/hay_fever_managing_hay_fever_symptoms/views.htm

http://www.mayoclinic.org/diseases-conditions/hay-fever/basics/definition/con-20020827

http://www.nhs.uk/conditions/Hay-fever/Pages/Prevention.aspx


GENETICVARIATIONS





rs2305480, rs8076131, rs887864






















SUMMARY

Symptoms of histamine intolerance vary from nasal congestion and headaches/dizziness toabdominal cramps, nausea, diarrhea, skin rashes, extreme tiredness. In other words, if you cannotput your finger on what triggers your symptoms but suspect it may be caused by food, talk to yourdoctor about getting tested for histamine intoleranceIn addition to genetics, histamine intolerance may be caused by hormone changes (menopause),medications, and high amounts of histamine in a mealFoods high in histamines include fermented alcoholic beverages, cured meats and smoked fish,matured cheeses, fermented and soured foods, shellfish, walnuts and cashew nuts, chocolates,most citric fruits, tomatoes, eggplants, snacks and sweets with preservatives and additives

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Histamine Intolerance2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 35% of the population and is consideredstatistically low compared to the general population.

WHATISHISTAMINEINTOLERANCE

Histamine intolerance is caused by excess of histamine because of an impaired function of the histamine-degrading enzyme diamine oxidase (DAO) and histamine N-methyl transferase (HNMT) that regulates airwayresponse to histamine. Histamine is produced as part of a local immune response to cause inflammation asa reaction to foreign particles (such as virus) or allergens (from plant pollen, dust mites, certain foods, foodadditives, alcohol). Histamine is also a neurotransmitter that conveys messages between neurons and itplays important role in regulating the permeability of the blood capillaries, and regulating levels of regulationof gastric acid. Histamine is present on our skin, lung and stomach. As a healthy reaction, histamine levelsrise as a response to allergens present in air, environment, foods, drink. Under normal physiologicalconditions, excess of histamine is quickly degraded. When the degradation process is impaired, it leads tohistamine intolerance. Genetic variants in the key degradation enzyme diamine oxidase DAO, and histamineN-methyl transferase (HMT) are associated with histamine intolerance.

HISTAMINEINTOLERANCE

YOU:

35NORMAL


WHATTODO

Symptoms of histamine intolerance vary from nasal congestion and headaches/dizziness to abdominalcramps, nausea, diarrhea, skin rashes, extreme tiredness. In other words, if you cannot put your finger onwhat triggers your symptoms but suspect it may be caused by food, talk to your doctor about getting testedfor histamine intolerance

In addition to genetics, histamine intolerance may be caused by hormone changes (menopause),medications, and high amounts of histamine in a mealFoods high in histamines include fermented alcoholic beverages, cured meats and smoked fish,matured cheeses, fermented and soured foods, shellfish, walnuts and cashew nuts, chocolates,most citric fruits, tomatoes, eggplants, snacks and sweets with preservatives and additives

NATUREVS.NURTURE


LEARNMORE

Learn more about Histamine Intolerance by checking out the following articles:

Everything You Need To Know About Histamine Intolerance Histamine Intolerance Awarness

GENETICVARIATIONS



rs10156191, rs1049793



http://www.mindbodygreen.com/0-11175/everything-you-need-to-know-about-histamine-intolerance.html

http://www.histamineintolerance.org.uk/




SUMMARY

Two well known genetic variants for lactose intolerance have been found in people of Europeandescent, and primarily from the North of Europe. Other ethnicities, including some South Europeans,are likely to have other genetic variants enabling them to digest lactose, and these have not yet beenconfirmed. So, if you are not of European descent, these results are not applicable to you.You seem to have a higher than average genetic risk of lactose intolerance, but this does not meanthat you actually express this sensitivity in your real life. If you do not experience any of the above-mentioned symptoms, there may be no reason cut backon your lactose-rich food.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Lactose Intolerance2 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 80% of the population and is consideredstatistically risky compared to the general population.

WHATISLACTOSEINTOLERANCE

Lactose intolerance means that the body cannot easily digest lactose, which is a natural sugar found in milkand dairy products. Symptoms include diarrhea, nausea, abdominal cramps, bloating and gas. For somepeople, these symptoms are very severe and their systems can not tolerate any lactose. For others, thesymptoms are milder and they just have to limit the amount of dairy products they consume.

Lactose intolerance symptoms generally show themselves after ingestion of food containing lactose. Theseinclude:

Milk, milkshakes and other milk-based beveragesWhip cream and coffee creamerIce cream, ice milk, and sherbetCheese of all kinds ButterPuddings and custards Cream soups and cream sauces.

LACTOSEINTOLERANCE

YOU:

80ELEVATED


Lactose intolerance is a consequence of a deficiency of a lactase enzyme. This deficiency may be genetic oracquired. Interestingly, up to 65% world’s population have reduced ability to digest lactose. Two geneticvariations have been frequently found in people (of European descent) who are lactose intolerant.

WHATTODO

Two well known genetic variants for lactose intolerance have been found in people of European descent, andprimarily from the North of Europe. Other ethnicities, including some South Europeans, are likely to haveother genetic variants enabling them to digest lactose, and these have not yet been confirmed. So, if you arenot of European descent, these results are not applicable to you.

You seem to have a higher than average genetic risk of lactose intolerance, but this does not meanthat you actually express this sensitivity in your real life. If you do not experience any of the above-mentioned symptoms, there may be no reason cut backon your lactose-rich food.You may also want to check if you may have predispositions for milk allergy. If you experience a few of the above-mentioned symptoms when consuming dairy products, cutback on your lactose-rich food and see if your symptoms subside. There are many alternatives to dairy products including lactose free milk, non-dairy creamers, ricemilk drinks and soymilkAlways consult with a physician before making major changes to your diet.

NATUREVS.NURTURE


LEARNMORE

Learn more about Lactose Intolerance by checking out the following articles:

Lactose Intolerance - Topic Overview

http://www.webmd.com/digestive-disorders/tc/lactose-intolerance-topic-overview


GENETICVARIATIONS



rs4988235, rs182549






SUMMARY


MYASSESMENT


WHATISMISOPHONIA


WHATTODO



MISOPHONIA

YOU:

5NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY

In addition to genetics, other factors contribute to motion sickness including travel anxiety andgeneral stress, headaches, intoxication, dehydrationIf you are traveling by car, risk factors include poor ventilation and sitting in the back seat or whereyou cannot see out the windowFor women, pregnancy or having a period are risk factors

MYASSESMENT

You seem to have elevated genetic predispositions risk for Motion Sickness17 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 90% of the population and is consideredstatistically risky compared to the general population.

WHATISMOTIONSICKNESS

Motion sickness (sometimes referred to as travel sickness) is a common condition that occurs in somepeople who travel by car, train, airplane or boat. Motion sickness is a general term, and the symptomsinclude nausea, dizziness, and fatigue. Roughly one in three individuals is susceptible to motion sickness,and almost two thirds report being sick in more sever conditions. About 7% of seagoing passengers reportvomiting during the journey. Charles Darwin once wrote to his father: "The misery I endured from sea-sickness is far far beyond what I ever guessed at. If it was not for sea-sickness, the whole world would besailors." Children, and older people are more susceptible to motion sickness, and women generally reportmore cases of motion sickness than men. Motion sickness happens when the body, the inner ear, and theeyes send conflicting signals to the brain. The first study on over 80 thousands individuals yielded geneticvariants associated with motion sickness. The study reports that several genetic variants show up to threetimes stronger effects in women. Some genetic variations increase the likelihood of motion sickness, whileother variants are protective. Interestingly, occurrences of motion sickness correlate with migraines, altitudesickness, morning sickness, postoperative nausea and vomiting, and poor sleeping.

MOTIONSICKNESS

YOU:

90ELEVATED


WHATTODO

In addition to genetics, other factors contribute to motion sickness including travel anxiety and generalstress, headaches, intoxication, dehydration

If you are traveling by car, risk factors include poor ventilation and sitting in the back seat or whereyou cannot see out the windowFor women, pregnancy or having a period are risk factorsIf you suffer from motion sickness, sit in the front in a car, keep your eyes on the horizon, or driveAvoid big fatty meals before your travel; avoid salty foods and alcoholFresh air helps: open windows in the car or move to the top deck of a shipIf you want to take medication to treat your motion sickness, take it before your journey to preventsymptoms developing. Discuss side effects with your pharmacist.

NATUREVS.NURTURE


LEARNMORE

Learn more about Motion Sickness by checking out the following articles:

The Mysterious Science of Motion Sickness Motion Sickness - Topic Overview

GENETICVARIATIONS






http://www.theatlantic.com/health/archive/2015/02/the-mysterious-science-of-motion-sickness/385469/

http://www.webmd.com/cold-and-flu/ear-infection/tc/motion-sickness-topic-overview



















SUMMARY

Do you hay fever? Mugwort pollen is a most common cause of hay fever, so it can be a triggerMugwort pollen cross-reacts with foods like honey, sunflower seeds, apple, carrot, celery, garlic,onion, peanut, pistachio, almond causing an oral allergy syndrome in people allergic to itIf you notice itchiness or swelling of the mouth, face, lip keep a food diary and monitor your intake offoods that can cross-react with mugwort pollen

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Mugwort AllergyResistance2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 20% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISMUGWORTALLERGYRESISTANCE

Mugwort is a perennial plant and a close relative of daisies, sunflowers, dandelions, and ragweed. Mugwortpollen is one of the main sources of hay fever and allergic asthma in North Europe, North America and partsof Asia. Mugwort allergy symptoms are almost identical to seasonal allergies (sneezing, coughing, redness ofeyes, itching, skin rashes). Often, allergy to mugwort is preceded by oral allergy syndrome that causesitchiness or swelling of the mouth, face, lip after eating some foods that are cross-reacted with mugwort. Insome cases, mugwort can cause severe skin rashes, eczema, asthma. Symptoms worsen during themugwort pollen season that runs from late summer to fall. Recent studies identified genetic variationsassociated with significantly decreased risk of allergy to mugwort pollen. People with these geneticvariations report significantly fewer cases of allergies mugwort pollen.

MUGWORTALLERGYRESISTANCE

YOU:

20TYPICAL


WHATTODO

Do you hay fever? Mugwort pollen is a most common cause of hay fever, so it can be a triggerMugwort pollen cross-reacts with foods like honey, sunflower seeds, apple, carrot, celery, garlic,onion, peanut, pistachio, almond causing an oral allergy syndrome in people allergic to itIf you notice itchiness or swelling of the mouth, face, lip keep a food diary and monitor your intake offoods that can cross-react with mugwort pollenIf your symptoms persist, take over the counter medicine or talk to your health-care provider abouttesting for mugwort pollen allergy

NATUREVS.NURTURE


GENETICVARIATIONS



rs631208


rs1898671




SUMMARY

There is a strong connection between noise and hearing loss. While you do not have geneticpredisposition to noise induced hearing loss, loud sounds are damaging to your hearingNoise is measured in decibels (dB): the higher the number, the louder the noise and the moredamage it can inflict on your hearing, in particular if it is prolonged. Noise levels above 105dB candamage your hearing if you listen to it for 15-20 minutes each week. A normal conversation is 60-65dB, lawn mower and heavy traffic is 85dB, while MP3 player on loud is 110dB, and rock concert is120dBTo protect your hearing, reduce the volume when listening to music, TV, radio; use earplugs at livemusic concerts; wear ear protectors when you are using lawn mowers or noisy equipment; do notlisten to music too loud and too long when driving

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Noise-induced Hearing Loss2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically low compared to the general population.

WHATISNOISE-INDUCEDHEARINGLOSS

Noise induced hearing loss is a temporary or permanent hearing impairment resulting from prolongedexposure to high levels of noise. Excessive noise exposure is the most common cause of hearing loss. Inmodern society we are constantly bombarded by noises, on our headphones, TVs, or in the cities. Whenthese sounds are at safe level they do not damage our hearing. But too loud sounds can damage inner earand cause noise-induced hearing loss (NIHL). Noise is probably the most common occupational hazardfacing people today. According to the National Institute on Deafness, "people of all ages, including children,teens, young adults, and older people, can develop NIHL. Approximately 15 percent of Americans betweenthe ages of 20 and 69—or 26 million Americans—have hearing loss that may have been caused by exposureto noise at work or in leisure activities. As many as 16 percent of teens (ages 12 to 19) have reported somehearing loss that could have been caused by loud noise". While too loud noises are not good for anyone,studies identified genetic variations associated with increased risk of NIHL.

NOISE-INDUCEDHEARINGLOSS

YOU:

5NORMAL


WHATTODO

There is a strong connection between noise and hearing loss. While you do not have genetic predispositionto noise induced hearing loss, loud sounds are damaging to your hearing

Noise is measured in decibels (dB): the higher the number, the louder the noise and the moredamage it can inflict on your hearing, in particular if it is prolonged. Noise levels above 105dB candamage your hearing if you listen to it for 15-20 minutes each week. A normal conversation is 60-65dB, lawn mower and heavy traffic is 85dB, while MP3 player on loud is 110dB, and rock concert is120dBTo protect your hearing, reduce the volume when listening to music, TV, radio; use earplugs at livemusic concerts; wear ear protectors when you are using lawn mowers or noisy equipment; do notlisten to music too loud and too long when drivingHave a hearing detox and introduce quiet periods during the day.

NATUREVS.NURTURE


LEARNMORE

Learn more about Noise-induced Hearing Loss by checking out the following articles:

Top 10 tips to help protect your hearing Noise-Induced Hearing Loss

GENETICVARIATIONS



rs7429015


rs2227578

http://www.nhs.uk/Livewell/hearing-problems/Pages/tips-to-protect-hearing.aspx

https://www.nidcd.nih.gov/health/noise-induced-hearing-loss




SUMMARY

While you may have an elevated resistance to novovirus, do follow general precautions in avoidingthe potentials of stomach fluWahs your hands! Using soap works much better than hand sanitizer, since the latter works mostlyfor bacteriaTry to avoid touching external surfaces such as in the subway or shopping carts

MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for Resistance ToStomach Flu1 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically advantaged compared to the general population.

WHATISRESISTANCETOSTOMACHFLU

Stomach Flu, or Norovirus, is not really the flu but a viral gastroenteritis, and the major cause of foodborneillness worldwide, responsible for at least 50% of all gastroenteritis outbreaks in the United States. It iscaused by a nasty bug and it is very contagious and causes unpleasant symptoms that include abdominalpain, vomiting and diarrhea. It turns out that some people may be safer than most during the flu season.About 30 percent of people of European ancestry and 20 percent of people with African ancestry carry thespecific version of the genetic variation on the FUT2 (secretor) gene that prevents the most common strain ofNovovirus bug to enter their digestive tract. These lucky people are resistant to most common strain ofstomach flu. Whether you have a typical predisposition to being infected by this bug or have genetic-basedresistance, it is always a good idea to minimize the risks by following recommended procedures.

RESISTANCETOSTOMACHFLU

YOU:

85ADVANTAGED


WHATTODO

While you may have an elevated resistance to novovirus, do follow general precautions in avoiding thepotentials of stomach flu

Wahs your hands! Using soap works much better than hand sanitizer, since the latter works mostlyfor bacteriaTry to avoid touching external surfaces such as in the subway or shopping cartsWhen there is an epidemic of stomach flu in your neighborhood, eat at home. A study published inthe PLOS ONE found that restaurant dishes and silverware may be an overlooked place wherepeople can catch stomach viruses

NATUREVS.NURTURE


GENETICVARIATIONS



rs601338





SUMMARY


MYASSESMENT


WHATISSEASONALITY


WHATTODO


SEASONALITY

YOU:

75SLIGHTLYELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs1808478, rs1801260, rs11825064, rs13257657








SUMMARY

You have a slightly elevated genetic predisposition likelihood for sensitivity to benzene. It means that youhave genetic variants associated with increased risk of toxicity caused by benzene, or higher risk of benzeneaccumulation. It is still a good idea to reduce your exposure to benzene by ensuring adequate ventilation inyour home, avoiding second hand smoke, using benzene free laundry detergents and other products. Toavoid household products that contain benzene consult https://householdproducts.nlm.nih.gov/cgi-bin/household/search. If you live in the city, keep plenty of plants in the home: they are known to clean theair from pollutants.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Sensitivity To Benzene3 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 60% of the population and is consideredstatistically risky compared to the general population.

WHATISSENSITIVITYTOBENZENE

Benzene is an industrial chemical and a ubiquitous pollutant of air largely from manufacturing and motorvehicle exhaust. Benzene may irritate the nose and throat, case coughing, wheezing, headache, dizziness,and skin allergies. It is a documented carcinogen and it may target different organs, including liver, kidney,lung, heart and the brain. Many products such as adhesives, laundry detergents, nail polishes, syntheticfabrics, dyes, still contain some levels of benzene. About 50% of the benzene exposure in the US resultsfrom smoking tobacco or from second-hand smoke. The metabolism of benzene has been extensivelyinvestigated and the cytochrome P450 enzyme (CYP2E1) plays a major role. Genetic variations in thisenzyme as well as in the EPHX1 and NQO1 genes increase susceptibility to benzene toxicity.

SENSITIVITYTOBENZENE

YOU:

60SLIGHTLYELEVATED


WHATTODO

You have a slightly elevated genetic predisposition likelihood for sensitivity to benzene. It means that youhave genetic variants associated with increased risk of toxicity caused by benzene, or higher risk of benzeneaccumulation. It is still a good idea to reduce your exposure to benzene by ensuring adequate ventilation inyour home, avoiding second hand smoke, using benzene free laundry detergents and other products. Toavoid household products that contain benzene consult https://householdproducts.nlm.nih.gov/cgi-bin/household/search. If you live in the city, keep plenty of plants in the home: they are known to clean theair from pollutants.

NATUREVS.NURTURE


GENETICVARIATIONS



rs2234922, rs2917666, rs1800566







SUMMARY

You have a slightly elevated predisposition likelihood for bioaccumulation of mercury. This means that youhave genetic variations that have been more frequently found in people with elevated levels of mercury intheir blood or hair. Follow general guidelines for eating a healthy balanced diet and eat up to 12 oz (340 g) aweek (two average meals) of a variety of fish and shellfish. Whenever possible, choose fish that are lower inmercury. When in doubt, remember smaller fish is better: anchovies, sardines, and scallops, which are lowerin mercury. FDA advises young children, and women who are or may become pregnant, and nursing mothersto avoid fish high in mercury.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Sensitivity To Mercury8 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically risky compared to the general population.

WHATISSENSITIVITYTOMERCURY

Mercury is a heavy metal found naturally in the environment. It is released into the air, water and soil byfactories and coal-burning power plants. In water, mercury changes its form and becomes methylmercurywhich is absorbed by fish. When this fish comes to your table, you absorb the mercury that may accumulatein your body and become harmful at high levels. Young children and fetuses are particularly sensitive tomercury as their nervous systems is developing. Mercury can be toxic to gastrointestinal, and renal, andnervous systems. Mercury will leave the body over time in the urine, feces (and breast milk) but studies showthat levels of mercury in human blood, hair depend on genetic variations.

WHATTODO

You have a slightly elevated predisposition likelihood for bioaccumulation of mercury. This means that youhave genetic variations that have been more frequently found in people with elevated levels of mercury intheir blood or hair. Follow general guidelines for eating a healthy balanced diet and eat up to 12 oz (340 g) aweek (two average meals) of a variety of fish and shellfish. Whenever possible, choose fish that are lower inmercury. When in doubt, remember smaller fish is better: anchovies, sardines, and scallops, which are lowerin mercury. FDA advises young children, and women who are or may become pregnant, and nursing mothersto avoid fish high in mercury.

SENSITIVITYTOMERCURY

YOU:

65SLIGHTLYELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS















SUMMARY

Make seafood choices carefully. Certain common fish high in good nutrients and omega-fats are also high inPCBs, including Atlantic and farmed salmon.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Sensitivity To PCB6 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically risky compared to the general population.

WHATISSENSITIVITYTOPCB

Polychlorinated biphenyls (PCBs) are a group of man-made chemicals. They are oily liquids or solids, clear toyellow in color, with no smell or taste. They have been long recognized as environmental pollutants thataccumulate in humans with adverse health effects. PCBs have been linked to various cancers, problems withimmune system and thyroid function, as well low birth weight, slowed growth and development in children.Manufacturing of PCBs was halted in the 70s but PCBs are still being released into the environment viahazardous waste sites, leaks, improper disposal. Since PCBs are found throughout the environment, it islikely that everyone has been exposed to them through food (fish and meats), water, and even old lightfixtures. PCBs are easily absorbed by the body, and like other lipophilic compounds they have to bemetabolized by the members of the cytochrome P450 system. People with lower activities of somecytochrome P450 enzymes may be under higher risk of PCB build-up due their slower excretion rates fromthe body.

WHATTODO

Make seafood choices carefully. Certain common fish high in good nutrients and omega-fats are also high inPCBs, including Atlantic and farmed salmon.

SENSITIVITYTOPCB

YOU:

85ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs1953884, rs7251950, rs4124633, rs4803418, rs8100458, rs7254579










An Overview of your important reports, Free with your DNA Kit or when you upload your existing DNA File.

BasicWellnessReports10 Reports in 8 groups

WeightProfileHave you asked yourself the question of why some people have more difficulty in losingweight? What is your overweight potential? What are your predispositions for lean bodymass potential? In this section you can gain an overall view on your weight profile andinsights on your unique biology.


MuscleBuildingThe muscle system is responsible for movement of the human body,posture, movement of substances inside the body and for the generation of body heat.Your overall muscle power and how much you can increase it with exercise dependsstrongly on your genetics. Your potentials for muscle injury, muscle cramps, musclesoreness after exercise and other muscle problems are also influenced by your genes.Explore the genetic basis of your muscle characteristics in this section.


SUMMARY

You seem to have a normal predisposition for caffeine metabolism. This means you can usuallyhave 200-400 mg of caffeine daily without any adverse reactions.This equates to 2-3 cups of brewed coffee (not Starbucks), two 16 fl.oz. energy drinks, or 7-8 cupsof black tea.You should not have no trouble sleeping as long as the caffeine is consumed early enough in theday.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Caffeine Metabolism ImpairmentNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 50% of the population and is consideredstatistically low compared to the general population.

WHATISCAFFEINEMETABOLISMIMPAIRMENT

Cytochrome P450 1A2 (CYP1A2) is the main responsible enzyme for the metabolism of caffeine. People withthe AA genotype at rs762551 (within the CYP1A2 gene) are fast metabolizers, while those with the AC or CCare slow metabolizers. For people with normal caffeine metabolism it only takes 45 minutes for 99% ofthe caffeine to be absorbed through these membranes. In humans, the half-life for caffeine is anywhere from4 to 6 hours on average, which explains why the average energy drink or coffee's effect lasts about 4 to 6hours. However those with genetic variations impairing their metabolism can become hypersensitive toCaffeine. These people react to very small amounts of caffeine. Even at amounts less than 100 mg, peoplewho are hypersensitive to caffeine can experience overdose symptoms such as insomnia, jitters, and anincreased heartbeat. For these people, it can take as much as twice as long for caffeine to metabolized.

CAFFEINEMETABOLISMIMPAIRMENT

YOU:

50NORMAL


WHATTODO

You seem to have a normal predisposition for caffeine metabolism. This means you can usually have 200-400 mg of caffeine daily without any adverse reactions.

This equates to 2-3 cups of brewed coffee (not Starbucks), two 16 fl.oz. energy drinks, or 7-8 cupsof black tea.You should not have no trouble sleeping as long as the caffeine is consumed early enough in theday.

NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY


MYASSESMENT


WHATISDRYNESS


WHATTODO


DRYNESS

YOU:

45NORMAL


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS










SUMMARY


MYASSESMENT

Great News! You seem to have Significant advantageous genetic predispositions for ExploratoryBehavior7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 90% of the population and is consideredstatistically advantaged compared to the general population.

WHATISEXPLORATORYBEHAVIOR

Exploratory behavior, or Novelty Seeking, is one of 4 temperaments according to the Cloningerâ€™s modelof personality. The other three are Harm Avoidance, Reward Dependence, and Persistence. Exploratorybehavior reflects the tendency to respond strongly to novelty and cues for reward. Explorers have thetendency to crave stimulation and thrills; they tend to be attracted by large crowds and bright colors.Interestingly, exploratory behavior is influenced by specific neurotransmitter pathways in the brain and it hasa heritable genetic component.

WHATTODO


EXPLORATORYBEHAVIOR

YOU:

90ADVANTAGED


NATUREVS.NURTURE


LEARNMORE

Learn more about Exploratory Behavior by checking out the following articles:

Some people never learn: the genetics of learning from our mistakes What's New? Exuberance for Novelty Has Benefits The Perils of Novelty Seeking

GENETICVARIATIONS



rs3120665, rs1533665, rs4680, rs4131099, rs1800955, rs10176705, rs7600563



https://www.psychologytoday.com/blog/fulfillment-any-age/201203/are-you-neophiliac

http://www.nytimes.com/2012/02/14/science/novelty-seeking-neophilia-can-be-a-predictor-of-well-being.html

https://www.psychologytoday.com/blog/the-athletes-way/201311/the-perils-novelty-seeking









SUMMARY

You can increase your joint flexibility by engaging in yoga exercises and other stretching exercises.Try the Hip Flexor exercise:

Assume a kneeling position and move one foot out to the front.Roll your hips forward and maintain an upright position with your upper body.You will feel this stretch in your back leg.

MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Joint Flexibility3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISJOINTFLEXIBILITY

While flexibility and range of motion can be improved with regular stretching, some people have inherentjoint flexibility that is a highly heritable trait. Genetic variants in several collagen genes alter amino acidsequence and change the amount of collagen proteins being produced affecting architecture andbiomechanical properties of some tissues, including ligaments. Therefore, people with these genetic variantsin general have higher range of motion and better joint laxity and flexibility. Interestingly, the research hasshown that violinists, flautists, and pianists with lax finger joints suffer less pain than their less flexible peers.An opposite spectrum of this is risk of non-contact soft tissue injuries while doing very active sports. Othergenetic variants in the collagen genes reduce joint flexibility and potentially protect from cruciate ligament,shoulder dislocation, and anterior cruciate ligament ruptures.

WHATTODO

You can increase your joint flexibility by engaging in yoga exercises and other stretching exercises.Try the Hip Flexor exercise:Assume a kneeling position and move one foot out to the front.

Roll your hips forward and maintain an upright position with your upper body.You will feel this stretch in your back leg.Hold the stretch for around a minute and repeat on the other side.

JOINTFLEXIBILITY

YOU:

25TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Joint Flexibility by checking out the following articles:

The Difference Between Mobility vs Flexibility, and How to Improve Them 7 ways to Improve Flexibility Flexibility, Mobility, and Stability

GENETICVARIATIONS



rs12722


rs970547, rs240736

http://vitals.lifehacker.com/mobility-vs-flexibility-the-difference-and-what-to-tra-1708380436

http://www.mensfitness.com/training/pro-tips/7-ways-improve-flexibility

https://www.fix.com/blog/flexibility-mobility-stability





SUMMARY


MYASSESMENT






YOU:

85ADVANTAGED



WHATTODO



NATUREVS.NURTURE


GENETICVARIATIONS



rs1801133, rs13702, rs17300539








SUMMARY


MYASSESMENT






YOU:

5TYPICAL


WHATTODO



NATUREVS.NURTURE


GENETICVARIATIONS



rs62205366





SUMMARY


MYASSESMENT




OVERWEIGHTPOTENTIAL

YOU:

95ELEVATED


WHATTODO


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



rs9939609, rs1042714, rs1421085, rs17782313, rs1801282, rs12970134, rs10830963














SUMMARY

Follow general recommendations to make sure your skin does not get excessive damage due to UVexposureAlways wear sunscreen with SPF40 or higher Monitor any changes in the color, size or texture of moles and other skin lesions

MYASSESMENT

You seem to have elevated genetic predispositions risk for Poor Tanning Ability7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 85% of the population and is consideredstatistically risky compared to the general population.

WHATISPOORTANNINGABILITY

Tanning is the physiologically stimulated response to ultraviolet (UV) radiation of the solar light. UV exposureincreases the production of eumelanin, a type of pigment melanin, that darkens the skin in an attempt toprotect it from the damage. Ability of skin to tan is variable and is determined by genetics. Many genes areinvolved in the production of melanin that is the substance that gives skin, hair, and eyes their color. Largestudies identified a number of genetic variants in the key pigmentation genes that are associated withtanning phenotype. Variants in the tyrosinase (TYR) gene variants encode skin color. MC1R gene is stronglyassociated with red hair, freckling and sun sensitivity: nearly all red-heads have genetic variants in the MC1Rgene, and hence diminished ability to tan. Similarly, genetic variants adjacent to OCA2 gene give lighter colorto the eyes. Another genetic variants of OCA2 is involved in the light skin tone in East Asians. People with anumber of genetic variants in the pigmentary genes tend to have lighter eye color, fair skin, and diminishedability to tan.

WHATTODO

Follow general recommendations to make sure your skin does not get excessive damage due to UVexposure

Always wear sunscreen with SPF40 or higher Monitor any changes in the color, size or texture of moles and other skin lesionsVisit dermatologist regularly to do a full-body check

POORTANNINGABILITY

YOU:

85ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs10831496, rs4785763, rs1393350, rs1015362, rs4911414, rs11648785, rs1805008











SUMMARY


MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Reading Aptitude20 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISREADINGAPTITUDE

Reading ability measures the processing and comprehension capacity of written language. Often, significantsimilarities can be observed among family members with regards to reading ability. While there is definitelyan environmental and social component, research has shown that genetics and heredity plays a major role inthe ability of people to process written language. There are known genetic variations that seem to contributeto the overall reading ability of individuals. Interestingly, about half of these genetic contributions are sharedby individuals who are also good at mathematical aptitude. Another interesting finding is that geneticvariations associated with reading abilities in English and Chinese overlap.

WHATTODO


READINGAPTITUDE

YOU:

25TYPICAL


NATUREVS.NURTURE


GENETICVARIATIONS





rs2179515, rs7765678, rs2038137, rs2038139, rs4504469, rs9461045, rs3212236, rs2143340,rs9467247, rs807701, rs1555090, rs1091047






















SUMMARY


MYASSESMENT


WHATISSEASONALITY


WHATTODO


SEASONALITY

YOU:

75SLIGHTLYELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs1808478, rs1801260, rs11825064, rs13257657








Explore your unique nutrition, metabolism and diet needs based on analysis of more than 8,000 geneticvariations. 49 Trait Reports, Risk Assessments and Recommendations.

NutritionReports49 Reports in 4 groups

NutritionalHabitsHave you wondered which diet is more effective for your unique biology? Unlike the adsin many magazines and the offers of many businesses, there is no universal best dietthat works for everyone. How you process carbs, fat and protein are unique to yourbody's enzymatic processes and your genetic makeup has a strong influence on whatworks best for sustainable weight loss. Learn more about how your genetics impactsyour diet and metabolism in this section.

VitaminBalanceVitamins allow your body to grow and develop. They also play important roles in bodilyfunctions such as metabolism, immunity and digestion. We test for 17 essentialvitamins, including vitamins A, C, D, E, and K and B vitamins such as riboflavin andfolate. Gain insights into how your genetic variations may influence how your bodyprocesses and absorbs vitamins.

MineralBalanceMinerals help your body grow, develop, and stay healthy. The body uses minerals toperform many different functions â€” from building strong bones to transmitting nerveimpulses. Some minerals are even used to make hormones or maintain a normalheartbeat. With Silverberry, you can explore how your unique genetics impacts theprocessing of more than 12 minerals and other micronutrients.

EnzymesandAntioxidantsDid you know there is a gene in your body that is responsible to metabolize caffeine?Have you been concerned about gluten? Have you experienced Lactose Intolerance? Inthis group of reports, you learn about how your body and its enzymes are wired todigest food.


SUMMARY

You seem to have a normal predisposition for caffeine metabolism. This means you can usuallyhave 200-400 mg of caffeine daily without any adverse reactions.This equates to 2-3 cups of brewed coffee (not Starbucks), two 16 fl.oz. energy drinks, or 7-8 cupsof black tea.You should not have no trouble sleeping as long as the caffeine is consumed early enough in theday.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Caffeine Metabolism ImpairmentNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 50% of the population and is consideredstatistically low compared to the general population.

WHATISCAFFEINEMETABOLISMIMPAIRMENT

Cytochrome P450 1A2 (CYP1A2) is the main responsible enzyme for the metabolism of caffeine. People withthe AA genotype at rs762551 (within the CYP1A2 gene) are fast metabolizers, while those with the AC or CCare slow metabolizers. For people with normal caffeine metabolism it only takes 45 minutes for 99% ofthe caffeine to be absorbed through these membranes. In humans, the half-life for caffeine is anywhere from4 to 6 hours on average, which explains why the average energy drink or coffee's effect lasts about 4 to 6hours. However those with genetic variations impairing their metabolism can become hypersensitive toCaffeine. These people react to very small amounts of caffeine. Even at amounts less than 100 mg, peoplewho are hypersensitive to caffeine can experience overdose symptoms such as insomnia, jitters, and anincreased heartbeat. For these people, it can take as much as twice as long for caffeine to metabolized.

CAFFEINEMETABOLISMIMPAIRMENT

YOU:

50NORMAL


WHATTODO

You seem to have a normal predisposition for caffeine metabolism. This means you can usually have 200-400 mg of caffeine daily without any adverse reactions.

This equates to 2-3 cups of brewed coffee (not Starbucks), two 16 fl.oz. energy drinks, or 7-8 cupsof black tea.You should not have no trouble sleeping as long as the caffeine is consumed early enough in theday.

NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY

Meet your daily calcium intake requirements from foods.Calcium is provided by a wide variety of foods.: fortified foods (milk, beverages, and cereals), dairyproducts (milk, kefir, Greek yogurt, hard cheeses), green leafy vegetables, sardines and salmon (withsoft bones), legumes and beans.You can assess your calcium intake by using this tool: http://www.iofbonehealth.org/calcium-calculator.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Calcium Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 55% of the population and is consideredstatistically low compared to the general population.

WHATISCALCIUMDEFICIENCY

Calcium is the most abundant mineral in the human body, and a major constituent of bones and teeth. Itplays a central role in the functions of your nervous system, muscles, controlling blood vessel and insulinsecretion. Calcium levels are tightly regulated. It is important to get enough calcium as long term calciumdeficiency can result in bone loss and osteoporosis. Calcium requirements increase after age of 50 forwomen and after age of 70 for men. Meeting your daily calcium intake long-term health benefits: fromreducing your risk of osteoporosis to regulating your blood pressure levels to decreasing chances for sometypes of cancer. Human body does not produce calcium, so you must get it through dietary sources. Toohigh calcium levels in the blood (hypercalcemia) are not good either as they may weaken the bones,contribute to kidney, heart and brain problems. It is important to consult your health care provider if you areconsidering taking calcium supplementation.

CALCIUMDEFICIENCY

YOU:

55NORMAL


WHATTODO

Meet your daily calcium intake requirements from foods.Calcium is provided by a wide variety of foods.: fortified foods (milk, beverages, and cereals), dairyproducts (milk, kefir, Greek yogurt, hard cheeses), green leafy vegetables, sardines and salmon (withsoft bones), legumes and beans.You can assess your calcium intake by using this tool: http://www.iofbonehealth.org/calcium-calculator.

NATUREVS.NURTURE


LEARNMORE

Learn more about Calcium Deficiency by checking out the following articles:

33 Vegetables High in Calcium What is calcium and what does it do?

GENETICVARIATIONS



rs7032317, rs838705


rs1801725

http://www.healthaliciousness.com/articles/high-calcium-vegetables.php

https://ods.od.nih.gov/factsheets/Calcium-Consumer/





SUMMARY


MYASSESMENT




WHATTODO


CARBOVERCONSUMPTION

YOU:

50NORMAL


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



rs838133, rs1542608, rs4702718, rs8019546


rs2840445








SUMMARY

Meet your daily choline intake requirementsThe following food sources are rich in choline: chicken and turkey liver, eggs, milk, peanuts, soybeans, legumes and enriched breakfast cereals. In addition, several fruits and vegetables, includingavocado, onions, spinach, Brussels sprouts and broccoli.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Choline Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 60% of the population and is consideredstatistically low compared to the general population.

WHATISCHOLINEDEFICIENCY

Choline is a water-soluble essential micronutrient. It is not actually considered a mineral, and it is usuallygrouped within the B-complex vitamins. Choline is a methyl donor and it is involved in many key processes,including methylation reactions, lipid transport, maintenance of the structural integrity of cell membranes,nerve signaling, and metabolism. Choline is vital for regulation of homocysteine levels, and normal brainfunctioning. As the liver and the muscles are the major organs for methyl group metabolism, cholinedeficiency causes muscle damage and abnormal deposition of fat in the liver, which may result in a conditioncalled nonalcoholic fatty liver disease. Choline can be made de novo in the body in small amounts but itmust largely be consumed in the diet for optimal health. Endurance athletes and bodybuilders may be athigher risk for choline deficiency. People who drink a lot of alcohol are prone to lower levels of choline.Studies recommend to increase choline intake during pregnancy and breastfeeding.

WHATTODO


CHOLINEDEFICIENCY

YOU:

60NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Choline Deficiency by checking out the following articles:

WebMD on Choline ALL About Choline

GENETICVARIATIONS



rs4646365, rs4646406, rs2236225



http://www.webmd.com/vitamins-supplements/ingredientmono-436-choline.aspx

http://lpi.oregonstate.edu/mic/other-nutrients/choline





SUMMARY

You may want to consider a slightly higher intake of coenzyme Q10 than the recommended average. CQ10 can be found in organ meats such as heart, liver, and kidney, as well as beef, fish, soy andcanola oils, peanuts, pistachios and sesame seeds.Research shows that CoQ10 has antioxidant benefits, it helps with heart disease, as well as skinappearance and fine wrinkles.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Coenzyme Q10 Deficiency4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISCOENZYMEQ10DEFICIENCY

Coenzyme Q10 (CoQ10) is a fat-soluble natural compound primarily synthesized by the body. It is alsoconsumed in the diet. Coenzymes generally help enzymes to ensure biochemical reactions run smoothly.CoQ10 is found in every cell of the body as it is needed for basic cellular functions. Cell mitochondriarequires CoQ10 to produce energy for cell growth and maintenance. CoQ10 is present in higherconcentrations in organs with higher energy requirements such as the kidneys, liver, and heart. CellularCoQ10 also functions as an antioxidant. Taking a combination of nutrients that include CoQ10 has beenfound to benefit patients with cardiovascular disorders, including quicker recovery from surgeries. Studiesidentified common genetic variants that are significantly associated with Q10 levels. One of the testedgenetic variations is in the NQO1 gene that helps to convert CoQ10 to a a bioavailable form, ubiquinol.People with genetic variations in the NQO1 gene may not be able to make that transformation. According tothe Mayo clinic, CoQ10 levels decline gradually with age. In addition, some prescription drugs may lowerCoQ10 levels. Rare genetic defects that cause primary CoQ10 deficiency (which is a severe disorder thatseverely compromises neuronal and muscular function), are not tested by Silverberry.

COENZYMEQ10DEFICIENCY

YOU:

95ELEVATED


WHATTODO

You may want to consider a slightly higher intake of coenzyme Q10 than the recommended average. CQ10 can be found in organ meats such as heart, liver, and kidney, as well as beef, fish, soy andcanola oils, peanuts, pistachios and sesame seeds.Research shows that CoQ10 has antioxidant benefits, it helps with heart disease, as well as skinappearance and fine wrinkles.Some medicines (statins and anticoagulants) may lower CoQ10 levels.If you consider CoQ10 supplementation, seek out the ubiquinol form that is the preferred form ofcoenzyme Q10 in the blood. This form is best transported to the mitochondria, where it plays out itscrucial role in the generation of energy from food.Because CoQ10 is fat-soluble, take with a meal containing fat.While no major side effects for CoQ10 have been reported, always tell your doctor if you are using adietary supplement.

NATUREVS.NURTURE


LEARNMORE

Learn more about Coenzyme Q10 Deficiency by checking out the following articles:

CoQ10â€™s â€œOtherâ€ Health Benefits All About Coenzyme Q10 by Micronutrient Information Center About Coenzyme Q10 By Mayo Clinic

http://www.lifeextension.com/magazine/2006/2/cover_coq10/

http://lpi.oregonstate.edu/mic/dietary-factors/coenzyme-Q10

http://www.mayoclinic.org/drugs-supplements/coenzyme-q10/evidence/hrb-20059019


GENETICVARIATIONS



rs2917666, rs1800566, rs686030, rs8500








SUMMARY

You may want to consider a higher intake of copper compared to the recommended dailyallowance. Food sources: shellfish, including oysters, organ meats (kidneys, liver), whole grains, beans, nuts,avocado, potatoes. Dark leafy greens, black pepper, and yeast are also sources of copper in thediet. In addition, dried fruits, chocolate, cocoa are also rich with copper.People who take high amounts of zinc, iron, or vitamin C may need more copper.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Copper Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 35% of the population and is consideredstatistically risky compared to the general population.

WHATISCOPPERDEFICIENCY

Copper is another essential trace mineral that has a number of important functions in the human body. It is aco-factor in many oxidation-reduction reactions and it plays important role in health of blood vessels, nerves,immune system, bones, and connective tissues (hair, skin, nails, tendons, ligaments). It is integral for energyproduction, formation of collagen, iron absorption. Copper has been used by the ancient Egyptians tosterilize drinking water and wounds, and Hippocrates used copper for variety of disorders. Copper is nowbeen added to skin-care products to reduce the appearance of fine lines, and boost skin elasticity. Severecopper deficiency is rare, and may be caused by malnutrition, disorders that impair nutrient absorption(Crohn's disease), some surgeries, and medications. Several genetic variants were associated with copperlevels and they may contribute to copper imbalances that are linked to impaired immune function, contributeto anemia, and premature skin aging.

COPPERDEFICIENCY

YOU:

35ELEVATED


WHATTODO

You may want to consider a higher intake of copper compared to the recommended daily allowance. Food sources: shellfish, including oysters, organ meats (kidneys, liver), whole grains, beans, nuts,avocado, potatoes. Dark leafy greens, black pepper, and yeast are also sources of copper in thediet. In addition, dried fruits, chocolate, cocoa are also rich with copper.People who take high amounts of zinc, iron, or vitamin C may need more copper.Copper supplements can interact with certain medications or cause copper toxicity, and even acutepoisoning. If you are considering using the latest copper-containing skin care products, be aware ofpotential metal hypersensitivity some people develop. Check Silverberry's contact sensitivity reportto see if you have an increased risk.Before you start taking copper supplementation, consult your doctor.

NATUREVS.NURTURE


LEARNMORE

Learn more about Copper Deficiency by checking out the following articles:

Copper Allergies Copper in Diet Determinants of Copper Needs Across the Life Span Copper: The New Skin Saver Copper: The New Skin Saver

http://www.livestrong.com/article/276340-copper-allergies/

https://www.nlm.nih.gov/medlineplus/ency/article/002419.htm

https://ods.od.nih.gov/News/Copper.aspx

https://ods.od.nih.gov/News/Copper.aspx

http://blog.23andme.com/23andme-research/snpwatch/snpwatch-new-genetic-insight-into-the-causes-of-eczema/


GENETICVARIATIONS



rs11204828, rs4528122


rs1175549





SUMMARY


MYASSESMENT




WHATTODO



FATOVERCONSUMPTION

YOU:

30NORMAL


NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



rs13290799, rs12327666







SUMMARY


MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Fat Taste PerceptionNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically low compared to the general population.

WHATISFATTASTEPERCEPTION

There is growing evidence that foods we crave are at least partially determined by our genetics. Geneticvariation in taste receptors (or taste buds) may account for differences in our food choices and dietaryhabits. Research reported that people with a variant in the CD36 gene do not taste dietary fats as much.These people crave fats more than people with who detect lower amounts of fats in food. In fact, there isconsistent emerging evidence that fat is the sixth primary taste, with some people being genetic super-tasters and others low-tasters of fat. Low fat taste perception is linked with dietary consumption of fattyfoods which in combination with other factors lead to extra weight.

WHATTODO


FATTASTEPERCEPTION

YOU:

5NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Fat Taste Perception by checking out the following articles:

Are You a Supertaster? Fat might be the sixth basic taste

GENETICVARIATIONS






http://theplate.nationalgeographic.com/2014/09/30/are-you-a-supertaster/

https://www.washingtonpost.com/national/health-science/fat-might-be-the-sixth-basic-taste/2012/06/04/gJQAt218DV_story.html


SUMMARY

While there are no indications of a genetic predisposition to food allergies, genetics is only part ofthe equation when it comes to allergies. Factors such as general health, immune system functioning,as well as other rare and yet unknown genetic and epigenetic mechanisms, have significantcontributions too. Do check your more specific allergies to eggs, milk, lactose and gluten within this section.Check out the 10 symptoms of food allergy above. If you experience four or more of thesesymptoms regularly after eating food, you may have a food allergy. Consult with your physician toassess whether tests are needed.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for General Food Sensitivities4 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 5% of the population and is consideredstatistically low compared to the general population.

WHATISGENERALFOODSENSITIVITIES

Over the past 20 years, food allergy has grown from a relatively uncommon condition to a major clinical andpublic health problem worldwide due to its increasing prevalence, potential fatality, as well as enormousmedical and economic impact. Up to 15 million Americans have food allergies, and up to 1 in every 13children (under 18 years of age) in the U.S may be affected by a food allergy. That is roughly two in everyclassroom. Researchers estimate that genetic factors may contribute to up to 80% of food allergies.However, genetic predisposition does not always manifest in a specific allergy. Factors such as generalhealth, immune system functioning, as well as other rare and yet unknown genetic and epigeneticmechanisms, have significant contributions too. Clinical food allergy is defined as immunoglobulin E (IgE)-mediated clinical reactivity to specific food proteins, and several genetic variations associated with foodallergies have been identified. A recent large-scale genome-wide study identified several genetic variantsassociated with at least one common food allergens.

The top 10 symptoms of food allergy, 30 minutes to 2 hours after ingesting a potential allergen include:

HeadacheLack of Attention/Focus

GENERALFOODSENSITIVITIES

YOU:

5NORMAL


Anxiety or DepressionBloatingGasConstipationDiarrheaExhaustionJoint painSkin Rash

WHATTODO

While there are no indications of a genetic predisposition to food allergies, genetics is only part of theequation when it comes to allergies. Factors such as general health, immune system functioning, as well asother rare and yet unknown genetic and epigenetic mechanisms, have significant contributions too.

Do check your more specific allergies to eggs, milk, lactose and gluten within this section.Check out the 10 symptoms of food allergy above. If you experience four or more of thesesymptoms regularly after eating food, you may have a food allergy. Consult with your physician toassess whether tests are needed. If you suspect food allergies you can modify your diet by eliminating certain foods (gluten-rich,lactose-rich, nuts, etc.) and exploring whether symptoms subside.

NATUREVS.NURTURE


GENETICVARIATIONS



rs9677476


rs4848780, rs11635085, rs2360969






SUMMARY

You do not seem to have known genetic predispositions to gluten sensitivity, but if you see some ofthe above mentioned symptoms in your daily life, you may want to pay attention to gluten in yourfood.Take the following glutensensitivityself-assessmentquiz (third party website, opens in a newwindow) to get some more insights.Another way to explore whether you would benefit from a gluten-free diet is to try it out and see ifpotential symptoms disappear.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Gluten Sensitivity1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 55% of the population and is consideredstatistically low compared to the general population.

WHATISGLUTENSENSITIVITY

Gluten is a protein found primarily in grains (wheat, rye, barley). Gluten sensitivity may affect up to 6 percentof the population. It is sometimes called non-celiac gluten sensitivity to distinguish it from celiac disease,which is an autoimmune condition. After eating foods with gluten, people with gluten sensitivity canexperience abdominal pain, diarrhea or constipation, and bloating. People sensitive to gluten can alsoexperience other symptoms, such as fatigue, headaches, and joint pain. According to a recent survey, morethan 30% of Americans actively try to avoid eating gluten. However, it is unclear whether this is warranted. Arecent study found that among 400 individuals who thought they were gluten intolerant, only 55 people(14.5%) actually had an issue with gluten. In some cases, people who eliminate gluten may end up gainingweight because these foods often have more calories than their gluten-containing counterparts.

Symptoms of Gluten Sensitivity include:

Digestive issues such as gas, bloating, diarrhea and even constipation.Fatigue, brain fog or feeling tired after eating a meal that contains gluten. Migraine headaches.Joint inflammationAnxiety, depression, mood swings and ADD.

GLUTENSENSITIVITY

YOU:

55NORMAL



Of course any of these symptoms in and of themselves are not a sufficient reason to suspect glutensensitivity or intolerance. Several genetic variations were found more frequently in people with glutensensitivity.

WHATTODO

You do not seem to have known genetic predispositions to gluten sensitivity, but if you see some of theabove mentioned symptoms in your daily life, you may want to pay attention to gluten in your food.

Take the following glutensensitivityself-assessmentquiz (third party website, opens in a newwindow) to get some more insights.Another way to explore whether you would benefit from a gluten-free diet is to try it out and see ifpotential symptoms disappear.Foods that are naturally gluten-free include:Fruits, Vegetables, Meat and poultry, Fish and seafood,Dairy, Beans, legumes, and nuts, rice, corn, soy, potato, beans, quinoaAs always check with your doctor before making any abrupt changes to your diet.

NATUREVS.NURTURE


LEARNMORE

Learn more about Gluten Sensitivity by checking out the following articles:

Celiac disease â€“ Genetic testing and clinical utility Low Gluten Diet Against the Grain


http://eurogene.blogspot.com/2010/02/celiac-disease-genetic-testing-and.html

http://www.livestrong.com/article/421992-low-gluten-diet/

http://www.newyorker.com/magazine/2014/11/03/grain


GENETICVARIATIONS



rs2305764





SUMMARY

Make sure to follow generally recommended guidelines for iron intake.There are two types of iron: heme iron from animal sources and non-heme iron from plant sources.Heme iron is absorbed more readily. Foods rich in heme iron include beef, poultry, liver, oysters,salmon, tuna. Good sources of non-heme iron include beans, fortified cereals, and dark leafy greenslike spinach.If you are into strenuous physical activity, make sure your iron levels are within the norm.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Iron Deficiency7 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISIRONDEFICIENCY

Iron is an essential mineral that our bodies need for many functions. Iron is a key element in the metabolismof almost all living organisms. It is a part many proteins, including oxygen-carrying proteins, hemoglobin(found in red blood cells) and myglobin (found in muscle cells). Iron is also an essential component ofantioxidant enzymes and metabolizing enzymes (cytochromes). Absorption, transport and storage of iron aretightly regulated, as iron is both an essential and potentially toxic. Iron deficiency is the most commonnutrient deficiency in the world. Symptoms of iron deficiency may include fatigue, rapid heart rate andpalpitations. Iron deficiency may interfere with physical and athletic performance. Young children, women ofchildbearing age, as well as vegetarians and vegans, are at higher risk of iron deficiency.

IRONDEFICIENCY

YOU:

30NORMAL


WHATTODO

Make sure to follow generally recommended guidelines for iron intake.There are two types of iron: heme iron from animal sources and non-heme iron from plant sources.Heme iron is absorbed more readily. Foods rich in heme iron include beef, poultry, liver, oysters,salmon, tuna. Good sources of non-heme iron include beans, fortified cereals, and dark leafy greenslike spinach.If you are into strenuous physical activity, make sure your iron levels are within the norm.Do not take iron supplements without supervision of a healthcare professional as too much iron isharmful to the body.

NATUREVS.NURTURE


LEARNMORE

Learn more about Iron Deficiency by checking out the following articles:

Iron What is iron and what does it do? Everything about Iron

GENETICVARIATIONS



rs9948708, rs855791, rs9990333, rs228916, rs1375515, rs651007, rs4820268



https://www.nlm.nih.gov/medlineplus/iron.html

https://ods.od.nih.gov/factsheets/Iron-Consumer/

http://lpi.oregonstate.edu/mic/minerals/iron









SUMMARY

To minimize the risk of iron build-up, monitor your red meat, animal liver and raw shellfish intakeIf you are into strenuous physical activity, make sure your iron levels are within the norm.Do not take iron supplements without supervision of a healthcare professional as too much iron isharmful to the body.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Iron Overload1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 40% of the population and is consideredstatistically low compared to the general population.

WHATISIRONOVERLOAD

While iron is an essential mineral, too much iron may damage your body. Genetic variations affect how muchiron is absorbed leading to iron overload despite normal iron intake. The excess of iron in the body can leadto fatigue, anorexia, dizziness, nausea, vomiting, headache, weight loss, and shortness of breath. Somepeople have a genetic disorder of iron metabolism, called hereditary haemochromatosis (HH) dubbed theCeltic Curse as people of Celtic ancestry are at higher risk for carrying the HH variants. As many as one in 10people have at least one genetic variation associated with iron overload. These people are carriers and theycan pass the gene on to their children but will not get the medical condition. Carriers, as well as other peoplewho have variants in genes that regulate iron absorption, can still have iron build up, in particular if theyconsume alcohol in excess, or suffer from liver inflammation.

WHATTODO

To minimize the risk of iron build-up, monitor your red meat, animal liver and raw shellfish intakeIf you are into strenuous physical activity, make sure your iron levels are within the norm.Do not take iron supplements without supervision of a healthcare professional as too much iron isharmful to the body.

IRONOVERLOAD

YOU:

40NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Iron Overload by checking out the following articles:

Hemochromatosis - Mayo Clinic Hemochromatosis, Also called: Iron Overload Disease

GENETICVARIATIONS



rs235756



http://www.mayoclinic.org/diseases-conditions/hemochromatosis/basics/definition/con-20023606

https://www.nlm.nih.gov/medlineplus/hemochromatosis.html



SUMMARY

Two well known genetic variants for lactose intolerance have been found in people of Europeandescent, and primarily from the North of Europe. Other ethnicities, including some South Europeans,are likely to have other genetic variants enabling them to digest lactose, and these have not yet beenconfirmed. So, if you are not of European descent, these results are not applicable to you.You seem to have a higher than average genetic risk of lactose intolerance, but this does not meanthat you actually express this sensitivity in your real life. If you do not experience any of the above-mentioned symptoms, there may be no reason cut backon your lactose-rich food.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Lactose Intolerance2 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 80% of the population and is consideredstatistically risky compared to the general population.

WHATISLACTOSEINTOLERANCE

Lactose intolerance means that the body cannot easily digest lactose, which is a natural sugar found in milkand dairy products. Symptoms include diarrhea, nausea, abdominal cramps, bloating and gas. For somepeople, these symptoms are very severe and their systems can not tolerate any lactose. For others, thesymptoms are milder and they just have to limit the amount of dairy products they consume.

Lactose intolerance symptoms generally show themselves after ingestion of food containing lactose. Theseinclude:

Milk, milkshakes and other milk-based beveragesWhip cream and coffee creamerIce cream, ice milk, and sherbetCheese of all kinds ButterPuddings and custards Cream soups and cream sauces.

LACTOSEINTOLERANCE

YOU:

80ELEVATED


Lactose intolerance is a consequence of a deficiency of a lactase enzyme. This deficiency may be genetic oracquired. Interestingly, up to 65% world’s population have reduced ability to digest lactose. Two geneticvariations have been frequently found in people (of European descent) who are lactose intolerant.

WHATTODO

Two well known genetic variants for lactose intolerance have been found in people of European descent, andprimarily from the North of Europe. Other ethnicities, including some South Europeans, are likely to haveother genetic variants enabling them to digest lactose, and these have not yet been confirmed. So, if you arenot of European descent, these results are not applicable to you.

You seem to have a higher than average genetic risk of lactose intolerance, but this does not meanthat you actually express this sensitivity in your real life. If you do not experience any of the above-mentioned symptoms, there may be no reason cut backon your lactose-rich food.You may also want to check if you may have predispositions for milk allergy. If you experience a few of the above-mentioned symptoms when consuming dairy products, cutback on your lactose-rich food and see if your symptoms subside. There are many alternatives to dairy products including lactose free milk, non-dairy creamers, ricemilk drinks and soymilkAlways consult with a physician before making major changes to your diet.

NATUREVS.NURTURE


LEARNMORE

Learn more about Lactose Intolerance by checking out the following articles:

Lactose Intolerance - Topic Overview

http://www.webmd.com/digestive-disorders/tc/lactose-intolerance-topic-overview


GENETICVARIATIONS



rs4988235, rs182549






SUMMARY


MYASSESMENT




WHATTODO


NATUREVS.NURTURE



YOU:

55NORMAL


LEARNMORE



GENETICVARIATIONS



rs838133, rs1350036, rs9553939


rs9939609, rs1421085








SUMMARY


MYASSESMENT




WHATTODO




YOU:

65NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs1011397, rs3811787, rs6818288, rs1549059, rs2075577









SUMMARY

You do not have any known predispositions that would indicate an impulse for lower vegetableintake.You should be fine consuming vegetables as prescribed by the FDA for the average population.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Low Vegetable IntakeNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISLOWVEGETABLEINTAKE

It is a well-known fact that consumption of fruits and vegetables adds important under-consumed nutrientsto diets. Fruits and vegetables reduce the risk of heart disease, stroke, and some cancers, and help manageweight. Most U.S. residents consume too few fruits and vegetables. It is important to ensure you haveadequate amounts of fruits and vegetables in your diet.

WHATTODO

You do not have any known predispositions that would indicate an impulse for lower vegetable intake.You should be fine consuming vegetables as prescribed by the FDA for the average population.

NATUREVS.NURTURE


LOWVEGETABLEINTAKE

YOU:

30NORMAL


LEARNMORE

Learn more about Low Vegetable Intake by checking out the following articles:

Fruits & Veggies-More Matter

GENETICVARIATIONS






http://fnic.nal.usda.gov/dietary-guidance/fruits-veggies-more-matters-resources/fruits-veggies-more-matters


SUMMARY


MYASSESMENT





YOU:

75ADVANTAGED




WHATTODO



NATUREVS.NURTURE


LEARNMORE








GENETICVARIATIONS



rs10850219, rs1042714, rs2306179, rs2241201, rs5883, rs7957619, rs3764261











SUMMARY


MYASSESMENT





YOU:

65SLIGHTLY

ADVANTAGED


WHATTODO



NATUREVS.NURTURE


LEARNMORE



GENETICVARIATIONS



















SUMMARY

Aim at intake of at least 8 milligrams of LZ. According to a study from Harvard University leads toover 40% lower risk for macular degeneration. This is needed to maintain your healthy vision.Eat the leafy and cruciferous vegetables of yellow, orange and green colors to get Lutein andzeaxanthin (LZ). Lutein is absorbed better when ingested with a small amount of fat, such as olive oilConsume all varieties of cooked summer and winter squash, peas, yellow corn, beet greens,pumpkin, Brussels sprouts, broccoli, romaine and iceberg lettuce, asparagus and carrots. These aregood food sources of LZ and contain between 1 to 4 milligrams of LZ per serving

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Lutein And Zeaxanthin Deficiency2 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 80% of the population and is consideredstatistically risky compared to the general population.

WHATISLUTEINANDZEAXANTHINDEFICIENCY

Lutein and zeaxanthin (LZ) are yellow to red xanthophylls, a type of naturally occurring carotenoids. They arefound in high concentrations in the macula of the human eye. In fact, the small yellowish area of the eyeretina near the optic disk that provides central vision, is called the "macula lutea", from the Latin macula(spot) and lutea (yellow). Lutein and zeaxanthin block blue light from reaching the underlying structures in theretina, reducing the risk of light-induced oxidative damage that could lead to macular degeneration andcataracts, which are the leading causes of visual impairment and acquired blindness. Lutein and zeaxanthinalso have important general antioxidant functions in the body. Along with other natural antioxidants,including vitamin C, beta carotene and vitamin E, they guard the body from damaging effects of free radicals.Lutein may also contribute to protection against atherosclerosis (buildup of fatty deposits in arteries), thedisease that leads to most heart attacks.

LUTEINANDZEAXANTHINDEFICIENCY

YOU:

80SLIGHTLYELEVATED


WHATTODO

Aim at intake of at least 8 milligrams of LZ. According to a study from Harvard University leads to over 40%lower risk for macular degeneration. This is needed to maintain your healthy vision.

Eat the leafy and cruciferous vegetables of yellow, orange and green colors to get Lutein andzeaxanthin (LZ). Lutein is absorbed better when ingested with a small amount of fat, such as olive oilConsume all varieties of cooked summer and winter squash, peas, yellow corn, beet greens,pumpkin, Brussels sprouts, broccoli, romaine and iceberg lettuce, asparagus and carrots. These aregood food sources of LZ and contain between 1 to 4 milligrams of LZ per servingInclude other sources of LZ: eggs, orange juice, corn, and other foods with yellow colorIf you consider LZ supplementation, discuss with your health care provider

NATUREVS.NURTURE


LEARNMORE

Learn more about Lutein And Zeaxanthin Deficiency by checking out the following articles:

Pigments in Colorful Vegetables May Ward off Macular Degeneration What is Lutein? Î±-Carotene, Î²-Carotene, Î²-Cryptoxanthin, Lycopene, Lutein, and Zeaxanthin

GENETICVARIATIONS



rs7755, rs6564851



http://www.hsph.harvard.edu/news/hsph-in-the-news/pigments-in-colorful-vegetables-may-ward-off-macular-degeneration/

https://www.nlm.nih.gov/medlineplus/druginfo/natural/754.html

http://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/carotenoids




SUMMARY

Meet your lycopene intake requirements from your diet: think cooked tomatoes (fresh tomato pastasauce, tomato juice, tomato soup, paste). Tomatoes account for more than 85% of the dietary intakeof lycopene in North American diets.Cook tomatoes with olive oil or other good fats as lycopene from cooked tomatoes is absorbed 2.5times better than from fresh tomatoes. To protect skin from sun damage, the Mayo clinicrecommends taking 55 grams of tomato paste in olive oil. This provides 16 milligrams of lycopeneInclude watermelons, guava, papaya, pink grapefruit in your diet, in particular if you happen to notlike tomatoes, or are allergic to them

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Lycopene Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 45% of the population and is consideredstatistically low compared to the general population.

WHATISLYCOPENEDEFICIENCY

Lycopene is a bright red carotene, and it gives many fruits and vegetables (tomatoes, watermelons, papayas,pink grapefruits, red carrots) their red color. Lycopene is the most powerful antioxidant that is commonlyfound in the diet: it has a high capacity to remove free radicals. It also helps to protect the skin from thedamage by sunlight. Lycopene is present at higher levels in skin, liver, lungs, prostate, colon and adrenalglands. Scientific studies have linked higher consumption of lycopene rich foods with reduced risk of variousdiseases, including cardiovascular disease, asthma, some cancers, and age-related vision problems.Lycopene has not got an official status of an essential nutrient. Nevertheless, it is widely consideredbeneficial for immune system, skin and eye health.

LYCOPENEDEFICIENCY

YOU:

45NORMAL


WHATTODO

Meet your lycopene intake requirements from your diet: think cooked tomatoes (fresh tomato pasta sauce,tomato juice, tomato soup, paste). Tomatoes account for more than 85% of the dietary intake of lycopene inNorth American diets.

Cook tomatoes with olive oil or other good fats as lycopene from cooked tomatoes is absorbed 2.5times better than from fresh tomatoes. To protect skin from sun damage, the Mayo clinicrecommends taking 55 grams of tomato paste in olive oil. This provides 16 milligrams of lycopeneInclude watermelons, guava, papaya, pink grapefruit in your diet, in particular if you happen to notlike tomatoes, or are allergic to themConsider lycopene supplementation. The lycopene from the supplements is about as easy for thebody to absorb as dietary lycopene. The Mayo clinic recommends taking lycopene supplementationfor various conditions and concerns, including heart diseases, blood pressure, infertility, and as ageneral antioxidant.

NATUREVS.NURTURE


LEARNMORE

Learn more about Lycopene Deficiency by checking out the following articles:

Intorduction to Lycopene by Mayo Clinic What is Lycopene Everything about Carotenoids

http://www.mayoclinic.org/drugs-supplements/lycopene/dosing/hrb-20059666

https://medlineplus.gov/druginfo/natural/554.html



GENETICVARIATIONS



rs6564851, rs7680948, rs12934922







SUMMARY

Follow generally recommended guidelines for magnesium intake. Foods rich in magnesium include: Nuts (brazil, almonds, cashews), seeds (pumpkin, sesame),avocados, oats and legumes are some of the best sources of magnesium. In addition, bananas anddark chocolate are rich in magnesium.If you are an athlete, and sweat a lot, or if you notice muscle cramps, weakness, or twitches, makesure your magnesium levels are adequate.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Magnesium Deficiency5 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 40% of the population and is consideredstatistically low compared to the general population.

WHATISMAGNESIUMDEFICIENCY

Magnesium is an essential mineral involved in numerous physiological pathways, including energymetabolism, nerve control, neurotransmitter release, and blood pressure regulation. Magnesium is animportant electrolyte needed for proper muscle function, strong bones and good heart health. Magnesiumimbalances have been linked to various complications such as muscle cramps, constipation, poor sleep,tension or migraine headaches, anxiety and depression, chronic fatigue and premenstrual syndrome. In along term, magnesium deficiency has been associated with higher risk of osteoporosis, hypertension,cardiovascular disease, insulin sensitivity. Several genetic variants have been associated with magnesiumlevels: some variants contribute to lower levels of magnesium, while others are associated with highermagnesium.

MAGNESIUMDEFICIENCY

YOU:

40NORMAL


WHATTODO

Follow generally recommended guidelines for magnesium intake. Foods rich in magnesium include: Nuts (brazil, almonds, cashews), seeds (pumpkin, sesame),avocados, oats and legumes are some of the best sources of magnesium. In addition, bananas anddark chocolate are rich in magnesium.If you are an athlete, and sweat a lot, or if you notice muscle cramps, weakness, or twitches, makesure your magnesium levels are adequate.Other signs of low magnesium include poor sleep, irritability, and headaches.Many diuretics, including caffeine, alcohol, as well prescription diuretic medicines, affect magnesiumlevels.If you consider taking magnesium supplementation, talk to your health care provider to discusspotential side effects, and to determine optimal dose.

NATUREVS.NURTURE


LEARNMORE

Learn more about Magnesium Deficiency by checking out the following articles:

Magnesium (Mg) What is magnesium and what does it do? Everything about Magnesium

GENETICVARIATIONS



rs11891, rs13146355, rs603894, rs448378


rs6838240

http://www.webmd.com/a-to-z-guides/magnesium-mg#1

https://ods.od.nih.gov/factsheets/Magnesium-Consumer/

http://lpi.oregonstate.edu/mic/minerals/magnesium







SUMMARY


MYASSESMENT






YOU:

85ADVANTAGED



WHATTODO



NATUREVS.NURTURE


GENETICVARIATIONS



rs1801133, rs13702, rs17300539








SUMMARY


MYASSESMENT

You no not seem to have known advantageous genetic predispositions for Monounsaturated FatsIncreased Benefits3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 55% of the population and is consideredstatistically compared to the general population. Therefore it is considered below a threshold whereit would be deemed a statistically advantageous trait.

WHATISMONOUNSATURATEDFATSINCREASEDBENEFITS

In addition to tremendous health benefits of omega-3 (alpha linoleic acid) and omega-6 (linoleic acid) fats,there are several other fats that are important for good health. These include monounsaturated (healthier)fatty acids such as omega-7 (palmitoleic acid found in macadamia nuts, for example), omega-9 (oleic acidfound in olive oil), as well as some saturated fats (for example, those found in coconut oil or peanuts). Thesefats are known for their anti-inflammatory properties, lowering triglycerides, reducing blood pressure. TheMediterranean Diet, known for its numerous health benefits, is heavily influenced by monounsaturated fats.They are also good for keeping heart healthy. Good quality monounsaturated fats are also beneficial for skinas they maintain water level in the epidermis and supply the ceramides and fats that keep the bricks andmortar of the skin and hair healthy and intact.

WHATTODO


MONOUNSATURATEDFATSINCREASEDBENEFITS

YOU:

55TYPICAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Monounsaturated Fats Increased Benefits by checking out the following articles:

What Are the Benefits of Polyunsaturated Fat?

GENETICVARIATIONS



rs7597155, rs102275, rs3134950



http://www.livestrong.com/article/346100-what-are-the-benefits-of-polyunsaturated-fat/





SUMMARY

You can follow the general guidelines for phosphorous intake. Adults are encouraged to consume atleast 1,000 mg of phosphorus per day. Beef, and chicken, and dairy products are good dietary sources of phosphorus. Fish, such as cod,tuna, sardines, halibut, whiting are all high in phosphorus. Beans, nuts and seeds are the best non-animal food source of phosphorus.Some health conditions (diabetes, Crohn disease and celiac disease) and medications (antacids anddiuretics) and heavy alcohol consumption interfere phosphorus levels in the body.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Phosphorus Deficiency2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 35% of the population and is consideredstatistically low compared to the general population.

WHATISPHOSPHORUSDEFICIENCY

Phosphorus is another essential mineral that is required by every cell in the body for normal functioning. It isthe second most abundant mineral in the body. It contributes to healthy bone mineralization and healthyteeth maintenance. In fact, about 85% of the body's phosphorus is in bones and teeth. In addition,phosphorus plays role in cell signaling, energy production, digestion, hormonal balance, proper nutrientutilization as well as muscle and nerve functioning. While serious dietary phosphorus deficiency isuncommon, low calcium-to-phosphorus intake ratio may be detrimental to bone health, especially in womenat increased risk for osteoporosis. Symptoms of phosphorus deficiency include weak bones, stiff joints,numbness, weakness, loss of appetite, anxiety. Too much phosphorus is not good either as it affects thebalance of minerals in the body.

PHOSPHORUSDEFICIENCY

YOU:

35NORMAL


WHATTODO

You can follow the general guidelines for phosphorous intake. Adults are encouraged to consume at least1,000 mg of phosphorus per day.

Beef, and chicken, and dairy products are good dietary sources of phosphorus. Fish, such as cod,tuna, sardines, halibut, whiting are all high in phosphorus. Beans, nuts and seeds are the best non-animal food source of phosphorus.Some health conditions (diabetes, Crohn disease and celiac disease) and medications (antacids anddiuretics) and heavy alcohol consumption interfere phosphorus levels in the body.

NATUREVS.NURTURE


LEARNMORE

Learn more about Phosphorus Deficiency by checking out the following articles:

Phosphorus and Your CKD Diet Everything about Phosphorus Phosphorus in Diet Calcium, Magnesium and Phosphorus Health Benefits

GENETICVARIATIONS



rs947583, rs1697421



https://www.kidney.org/atoz/content/phosphorus

http://lpi.oregonstate.edu/mic/minerals/phosphorus

https://www.nlm.nih.gov/medlineplus/ency/article/002424.htm

http://www.livestrong.com/article/368873-calcium-magnesium-and-phosphorus-health-benefits/




SUMMARY

You have genetic variations in or near the FADS enzymes that play key roles in fatty acidmetabolism, thereby requiring additional sources of omega-3 and omega-6 in your diet.While both omega 3 and omega6 fatty acids are essential, the goal is to increase the intake ofomega-3 fats while limiting the intake of omega-6 fats (from fried and processed foods).Aim to eat fish high in DHA and EPA omega-3 fatty acids two to three times a week.

MYASSESMENT

Good News! You seem to have some advantageous genetic predispositions for PolyunsaturatedFats Increased Benefits7 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 70% of the population and is consideredstatistically advantaged compared to the general population.

WHATISPOLYUNSATURATEDFATSINCREASEDBENEFITS

Polyunsaturated fats are mainly omega-3 and omega-6 fatty acids. Omega-3 fats are a key family ofpolyunsaturated fats (EPA/DHA/ALA) that humans must get from food. Omega-3s are beneficial for the heartand brain health: they lower blood pressure and heart rate, improve blood vessel function, reducetriglycerides and system inflammation. They are good for eye health and skin appearance. Scientific studiesshow that omega-3s can help fight depression and improve attention. Along with omega-3 fats, omega-6fats play a crucial role in brain function, and normal growth and development. Omega-6s help stimulate skinand hair growth, maintain bone health, regulate metabolism, and maintain the reproductive system. Severallarge-scale studies identified genetic variations in and near the FADS enzymes that interfere with metabolismof omega-3 and omega-6 fats. While both omega-3 and omega-6 fatty acids are essential for human body, ahealthy diet should contain an equal ratio of omega-6 to omega-3. The main problem with a typical Westerndiet is that it contains way too many Omega-6s relative to Omega-3s.

POLYUNSATURATEDFATSINCREASEDBENEFITS

YOU:

70SLIGHTLY

ADVANTAGED


WHATTODO

You have genetic variations in or near the FADS enzymes that play key roles in fatty acid metabolism,thereby requiring additional sources of omega-3 and omega-6 in your diet.

While both omega 3 and omega6 fatty acids are essential, the goal is to increase the intake ofomega-3 fats while limiting the intake of omega-6 fats (from fried and processed foods).Aim to eat fish high in DHA and EPA omega-3 fatty acids two to three times a week.These include anchovies, herring mackerel, salmon (wild has more omega-3s than farmed), sardines,lake trout, tuna. Walnuts and flaxseed have omega-3s and 6s too.Talk to your doctor or registered dietitian about optimizing your dietary intake of omega 3 and 6 fattyacids. Getting professional advice is particularly important if you are taking medications.

NATUREVS.NURTURE


GENETICVARIATIONS



rs174548, rs3134950, rs10761785, rs174550, rs174546, rs174547, rs174537











SUMMARY


MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Risk From Saturated Fats1 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 70% of the population and is consideredstatistically risky compared to the general population.

WHATISRISKFROMSATURATEDFATS

It is no secret that large amounts of saturated fats are not good for anyone. People with genetic variations inthe FABP and APOA2 genes were found to be under higher risk of elevated triglycerides, elevatedcholesterol and extra weight.

WHATTODO


NATUREVS.NURTURE


RISKFROMSATURATEDFATS

YOU:

70SLIGHTLYELEVATED


GENETICVARIATIONS



rs1799883





SUMMARY


MYASSESMENT




WHATTODO


SATIETYIMPAIRMENT

YOU:

65SLIGHTLYELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs1137101, rs9939609, rs992472







SUMMARY

You may want to consider a higher intake of selenium than the recommended daily allownace. The richest food sources of selenium are organ meats (calf's liver) and seafood, followed by musclemeats. Selenium is present in soil and therefore is most highly concentrated in plant-based foodsgrown in selenium-rich soil, including fruits, vegetables and breads. The selenium content of food ishighly variable because it depends so heavily on soil conditions. Highly regarded sources ofselenium include a variety of mushrooms (in particular crimini and shiitake mushrooms), and Brazilnuts.Selenium can be toxic at high levels.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Selenium Deficiency9 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISSELENIUMDEFICIENCY

Selenium (Se) is an essential trace mineral that plays important role in healthy functioning of reproductiveand immune systems, and thyroid gland. Selenium is a powerful antioxidant, and it is a part of more than twodozen selenoproteins that act in synergy with vitamin C, vitamin E and glutathione. Selenium deficiencies ingeneral population are more frequent in the areas with low levels of selenium in the soil. In the US, seleniumconcentrations in the soil are higher in Midwestern and Western States than in the South and Northeast. Inthe UK, according to several studies, many soils are deficient in selenium. Very low concentrations ofselenium in some areas of China led to government-sponsored supplementation program. Individuals withselenium imbalances are more susceptible to physiological responses to stress. Research suggests thatoptimal selenium intake contributes to lower risk of age-related chronic diseases, longevity, and boostsfertility. Several genetic variations have been found to be associated with lower levels of selenium. Life-stylefactors that contribute to selenium imbalances include smoking, excessive alcohol consumption, stress, oralcontraception, and auto-immune conditions (such as rheumatoid arthritis, lupus, celiac disease).

SELENIUMDEFICIENCY

YOU:

95ELEVATED


WHATTODO

You may want to consider a higher intake of selenium than the recommended daily allownace. The richest food sources of selenium are organ meats (calf's liver) and seafood, followed by musclemeats. Selenium is present in soil and therefore is most highly concentrated in plant-based foodsgrown in selenium-rich soil, including fruits, vegetables and breads. The selenium content of food ishighly variable because it depends so heavily on soil conditions. Highly regarded sources ofselenium include a variety of mushrooms (in particular crimini and shiitake mushrooms), and Brazilnuts.Selenium can be toxic at high levels.Consult healthcare practitioner if you consider taking selenium supplements.

NATUREVS.NURTURE


GENETICVARIATIONS



rs2163813, rs6586282, rs6859667, rs352889, rs632057, rs705415, rs234709, rs7702905, rs567754













SUMMARY

You may want to consider reducing your daily intake of sodium well below the recommended 2300mgs. Some ways to reduce salt intake include: limiting processed and prepared foods, eating fresh ratherthan packaged meats, choosing fresh fruit and vegetables.Read food labels to look for hidden salt in foods like bread, bagels, cottage cheese or pies.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Sensitivity To Salt11 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISSENSITIVITYTOSALT

Sodium, the primary element we get from salt, is essential for life. It is important for multiple body functionsfrom maintaining the proper balance of water and minerals, to conducting nerve impulses, and musclecontractions. Too much sodium in the diet can lead to fluid retention, and high blood pressure. If thisbecomes chronic, it can lead to heart disease, stroke, kidney disease and congestive heart failure.Individuals vary considerably in their response to sodium intake, and salt-sensitivity (a measure of how yourblood pressure responds to salt intake) is at least in part determined by genetics. The mechanismsunderlying salt sensitivity are complex. The kidney is critical to overall fluid and electrolyte balance and long-term regulation of blood pressure.

SENSITIVITYTOSALT

YOU:

95ELEVATED


WHATTODO

You may want to consider reducing your daily intake of sodium well below the recommended 2300 mgs. Some ways to reduce salt intake include: limiting processed and prepared foods, eating fresh ratherthan packaged meats, choosing fresh fruit and vegetables.Read food labels to look for hidden salt in foods like bread, bagels, cottage cheese or pies.Salt preference is an acquired taste that can be unlearned. It takes about 6-8 weeks to get used toeating food with much lower quantities of salt, but once it is done, its actually difficult to eat foodslike potato chips because they taste way too salty.Among people who are salt-sensitive, excess sodium intake in the long term may result in high bloodpressure, heart problems, increased calcium loss in the urine, osteoporosis, stomach cancer, orasthma.If you see these symptoms regularly, discuss your concerns with your physician.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1805152, rs7571842, rs7961152, rs1739843, rs699, rs9402571, rs2758151, rs4149601, rs2288774,rs1010069


rs11674786













SUMMARY

You do not seem to have genetic-driven impulse for frequent snacking.Keep a healthy diet and exercise as appropriate for your age group.Try to eat healthy snacks such as baby carrots and celeries rather than chips and salsa!

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Snacking1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 50% of the population and is consideredstatistically low compared to the general population.

WHATISSNACKING

Some people feel hungry more often than others and are impulsively driven to frequent snacking, which if leftunchecked can result in extra weight. Variations in the MC4R, leptin receptor (LEPR), NMB and BDNF genes,have been linked to increased snacking. Genetic variations in the MC4R gene are also significantlyassociated with higher BMI and obesity.

WHATTODO

You do not seem to have genetic-driven impulse for frequent snacking.Keep a healthy diet and exercise as appropriate for your age group.Try to eat healthy snacks such as baby carrots and celeries rather than chips and salsa!A good goal for a between-meal snack is something with fewer than 100 calories. Generous portionsof fruits or vegetables can easily help fill you up while staying below that calorie count.

SNACKING

YOU:

50NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs17782313





SUMMARY

Your ability to metabolize starch-rich diet is typicalStarchy foods often need to be limited if you're following a low-carb diet.However, the U.S. Department of Agriculture recommends you fill one-fourth of your plate with thesefoods at each meal since they provide essential nutrients.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Starch Metabolism2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.

WHATISSTARCHMETABOLISM

Starch is a complex carbohydrate. Foods high in starch include grains (oats, barley, rice), and starchyvegetables (potatoes, beans, corn, lentils). Starch is metabolized by a digestive enzyme, called amylase. Insome people, amylase can account for up to half of total protein in the saliva, while other people have barelydetectable levels of this enzyme. Large variation in levels of amylase depends on various factors, includingstress, as well as genetics. Interestingly, populations who historically relied on starch (rice, potato) for dietaryenergy have higher levels of the amylase than populations who consumed high-protein diets. People withhigh levels of amylase were found to be good metabolizers of starch-rich diet, while people with low levels ofamylase enzyme are poor metabolizers of starch, and they may be at greater risk for increased bloodglucose levels, insulin resistance and diabetes if they consume starch-rich diets.

STARCHMETABOLISM

YOU:

10NORMAL


WHATTODO

Your ability to metabolize starch-rich diet is typicalStarchy foods often need to be limited if you're following a low-carb diet.However, the U.S. Department of Agriculture recommends you fill one-fourth of your plate with thesefoods at each meal since they provide essential nutrients.Your body needs 5 to 8 ounces per day from the breads and grains group, depending on your ageand activity level, at least half of which should come from whole grains. A slice of bread, one-halfcup of oatmeal or rice, a mini bagel, a cup of dry cereal and 3 cups of popcorn are all equivalent to 1ounce.You should also consume 4 to 6 cups of starchy vegetables and 1 to 2 cups of beans each week asa part of your daily recommended intake of 2 to 3 cups of vegetables.

NATUREVS.NURTURE


GENETICVARIATIONS

There are 2 genes within your DNA that influence this trait.You have No contributing and 2 inhibiting genes that affect this trait.




rs1930212, rs6696797




SUMMARY

You have an elevated genetics-driven preference for sweet snacks over salty and savory.Healthy snacks can satisfy your hunger and keep you from eating extra helpings at your next meal,which can lower total daily calories.Snacks can also supply afternoon energy and extra nutrients.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Sweet Snack Preference2 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 90% of the population and is consideredstatistically risky compared to the general population.

WHATISSWEETSNACKPREFERENCE

Scientists from 23andme looked at taste preferences among about over 110,000 customers of Europeanancestry and identified two genetic biomarkers associated with preference of sweet snacks to salty or savoryones. The study identified variants in two genes, FGF21 and FTO. These genes are not associated withsweet tooth and taste receptors. These genes affect how people metabolize food. This is yet anotherexample that while your culture, habits and your age influence the foods you tend to like, genetics plays itimportant role too.

WHATTODO

You have an elevated genetics-driven preference for sweet snacks over salty and savory.Healthy snacks can satisfy your hunger and keep you from eating extra helpings at your next meal,which can lower total daily calories.Snacks can also supply afternoon energy and extra nutrients.If you're trying to lose weight, try these 100-calorie snacks: 1 cup sliced bananas and freshraspberries; 2 cups of carrots; 3 1/2 cups air-popped popcorn; 5 rye or pumpernickel crackers; 2tablespoons of peanuts; 2 domino-sized slices of low-fat colby or cheddar cheese.

SWEETSNACKPREFERENCE

YOU:

90ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs838133, rs1421085






SUMMARY

While you may crave sugars and sugary foods and drinks but this is more likely to be an acquiredtaste rather than genetically influenced.It is very important to monitor your sugar intake. If you are serious about controlling your sugarcravings, it may be easier for you to do than you think.Aim at getting your sugar craving naturally. Avoid processed foods, read the labels, do not gohungry, and make sure your blood sugar is stable.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Sweet Tooth1 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISSWEETTOOTH

A person with a sweet tooth has a higher sugar craving than the average person. If a person has a highsweet tooth predisposition, it is likely that they will often crave sweets and snack on sugary foods. Geneticvariations in TAS1R2, GLUT2, FUT1, may be responsible for sugar cravings, and preference of sweetsnacks. This may lead to weight gain, elevated glucose levels as well as pose future threats of Type-IIdiabetes, in particular in people with predispositions to these conditions. Remember, it is recommended thathealthy adults may consume of added sugars up to to 150 calories per day (37.5 grams or 9 teaspoons) formen, and 100 calories per day (25 grams or 6 teaspoons) for women.

WHATTODO

While you may crave sugars and sugary foods and drinks but this is more likely to be an acquired tasterather than genetically influenced.

It is very important to monitor your sugar intake. If you are serious about controlling your sugarcravings, it may be easier for you to do than you think.Aim at getting your sugar craving naturally. Avoid processed foods, read the labels, do not gohungry, and make sure your blood sugar is stable.Eat more greens, fermented foods and sea vegetables.Finally. drink plenty of water, exercise, and be outdoors.

SWEETTOOTH

YOU:

30NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs3935570





SUMMARY


MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Trans Fats Sensitivity11 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 60% of the population and is consideredstatistically risky compared to the general population.

WHATISTRANSFATSSENSITIVITY

Trans fatty acids (trans fats) cannot be synthesized by humans. Trans fats are considered the worst type offat you can eat. Trans fats are of two types: natural and artificial. Natural trans fats can be found in smallquantities in dairy and meat products. Artificial trans fats are created in an industrial process that addshydrogen to liquid vegetable oils, producing partially hydrogenated oils. Trans fats are linked to adversehealth outcomes: they raise bad cholesterol levels (LDL) and lower good cholesterol levels (HDL), increaserisk of developing heart diseases and type 2 diabetes. It is common knowledge that trans-fats are nothealthy. People with genetic variants in or near the fatty acid desaturase (FADS1 and 2) cluster are moresensitive to adverse effects of trans fats.

WHATTODO


TRANSFATSSENSITIVITY

YOU:

60SLIGHTLYELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs174548, rs174549, rs102275, rs174576, rs1535, rs174550, rs174556, rs174546, rs174547,rs174534, rs174537















SUMMARY

Meet your daily nutrient intake requirements for carotenoidsVitamin A is included in most multivitamins, and the U.S. recommended dietary allowance (RDA) foradults is as follows: 900 micrograms daily (3,000 IU) for men and 700 micrograms daily (2,300 IU) forwomen; for pregnant women 19 years old and older, 770 micrograms daily (2,600 IU); and forlactating women 19 years old and older, 1,300 micrograms daily (4,300 IU). (Source: May Clinic) Best carotenoid-rich foods are sweet potatoes, carrots, broccoli, kale, spinach, pumpkin, collardgreens, apricot, papaya, mango, peas, tomatoes, cheddar cheese and eggs

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Vitamin A (Carotene) Deficiency2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 40% of the population and is consideredstatistically low compared to the general population.

WHATISVITAMINA(CAROTENE)DEFICIENCY

Vitamin A, the group of fat-soluble vitamins, is essential for immune system functioning, reproduction,healthy vision, maintenance of strong bones and teeth, red blood cell production, tissue repair and skinhealth. Vitamin A comes in two forms: biologically active form, retinol, and pro-vitamin A carotenoids(including alpha- and beta-carotenes) that are converted into retinol. Carotenoids are important antioxidantsand anti-inflammatory agents, and have tremendous protective benefits for heart conditions, respiratoryproblems, elevated glucose levels, and various other ailments. Alpha and beta-carotenes contribute to skinand hair health. Humans cannot produce carotenoids themselves and therefore need it directly from foodsources. Carotenoids come from plant sources. Carotenoid-rich foods are often, but not always, haveorange, bright red, or yellow colors. In fact, the word carotene comes from the Latin word for carrot. Geneticvariants in CD36 and SCARB1 genes have been linked to lower levels of beta-carotene.

VITAMINA(CAROTENE)DEFICIENCY

YOU:

40NORMAL


WHATTODO

Meet your daily nutrient intake requirements for carotenoidsVitamin A is included in most multivitamins, and the U.S. recommended dietary allowance (RDA) foradults is as follows: 900 micrograms daily (3,000 IU) for men and 700 micrograms daily (2,300 IU) forwomen; for pregnant women 19 years old and older, 770 micrograms daily (2,600 IU); and forlactating women 19 years old and older, 1,300 micrograms daily (4,300 IU). (Source: May Clinic) Best carotenoid-rich foods are sweet potatoes, carrots, broccoli, kale, spinach, pumpkin, collardgreens, apricot, papaya, mango, peas, tomatoes, cheddar cheese and eggsCarotenoids need to be consumed with a fat for the body to absorb them: cook carotenoid-containing vegetables in oil

NATUREVS.NURTURE


GENETICVARIATIONS



rs17263407, rs1984112






SUMMARY

Optimize your retinol intakeBest retinol-rich foods include animal liver, egg yolks, butter and heavy creamIf you a pregnant or nursing woman; or/and vegetarian/vegan, you are under higher risk of retinoldeficiency, and you need to make sure you are meeting your daily requirements for this essentialvitamin

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Vitamin A (Retinol) Deficiency4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 70% of the population and is consideredstatistically risky compared to the general population.

WHATISVITAMINA(RETINOL)DEFICIENCY

Vitamin A, the group of fat-soluble vitamins, is essential for immune system functioning, reproduction,healthy vision, maintenance of strong bones and teeth, red blood cell production, tissue repair and skinhealth. Vitamin A comes in two forms: biologically active form, retinol, and pro-vitamin A carotenoids(including beta-carotene, lutein, lycopene) that need to be converted into retinol to be useful in the body.Carotenoids come from plant sources, while retinol comes from animal sources. Some specific immune,inflammatory, genetic, and reproductive-related benefits of vitamin A can only be obtained from the retinoidforms of the vitamin A. These retinoid forms can be especially important with respect to pregnancy andchildbirth, infancy, childhood growth, and resistance to infectious disease. Plasma retinol levels do notdecline until liver vitamin A sources are almost depleted and thus do not accurately reflect retinol imbalance.Studies show that variations in several key genes in retinol metabolism pathway impair the conversion ofcarotenoids to retinol, increase breakdown, or decrease absorption of retinoic acid, therefore affecting thelevels of retinol.

VITAMINA(RETINOL)DEFICIENCY

YOU:

70SLIGHTLYELEVATED


WHATTODO

Optimize your retinol intakeBest retinol-rich foods include animal liver, egg yolks, butter and heavy creamIf you a pregnant or nursing woman; or/and vegetarian/vegan, you are under higher risk of retinoldeficiency, and you need to make sure you are meeting your daily requirements for this essentialvitaminIf you consider retinol supplementation, consult a doctor or a registered dietitian

NATUREVS.NURTURE


GENETICVARIATIONS



rs10882272, rs6564851, rs6420424, rs12934922








SUMMARY

You may benefit from slightly extra intake of thiamine above the recommended daily allowance. Make sure you meet your daily requirement for thiamine through your diet.Adults (18 years and older) The following doses are the U.S. recommended daily allowance (RDA)of thiamine taken by mouth: in adults 19 and older, 1.2 milligrams for males and 1.1 milligrams forfemales; and in pregnant or breastfeeding women of any age, 1.4 milligrams. The best sources of thiamin include yeast extract, pork, fortified breakfast cereals, enriched grainproducts and soy products.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Vitamin B1 Deficiency1 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically risky compared to the general population.

WHATISVITAMINB1DEFICIENCY

Vitamin B1 (Thiamine), the first vitamin B that was discovered, is sometimes called anti-stress vitamin as itimproves body`s ability to withstand stress, strengthens the immune system, fights depression and assistshealthy functioning of the nervous system. Thiamine is involved in several enzyme functions associated withthe metabolism of carbohydrates, and fatty acids. Severe thiamine deficiencies are rare (except in critically illpeople and alcoholics) and they are associated with genetic diseases such as maple syrup urine disease andberiberi. Thiamine imbalances can result from poor dietary intake, reduced gastrointestinal absorption,increased metabolic requirements, or excessive loss of thiamin due to genetic variations.

VITAMINB1DEFICIENCY

YOU:

65SLIGHTLYELEVATED


WHATTODO

You may benefit from slightly extra intake of thiamine above the recommended daily allowance. Make sureyou meet your daily requirement for thiamine through your diet.

Adults (18 years and older) The following doses are the U.S. recommended daily allowance (RDA)of thiamine taken by mouth: in adults 19 and older, 1.2 milligrams for males and 1.1 milligrams forfemales; and in pregnant or breastfeeding women of any age, 1.4 milligrams. The best sources of thiamin include yeast extract, pork, fortified breakfast cereals, enriched grainproducts and soy products.Additional risk factors include gluten free and low gluten diet, depression, stress, and excessivealcohol consumption.Consult your healthcare provider if you consider thiamine supplementation.

NATUREVS.NURTURE


GENETICVARIATIONS



rs11691652





SUMMARY

There is no need to change your dietary intake beyond generally recommended guidelines.Recommended dietary amounts (RDAs) are 2.4 micrograms daily for ages 14 years and older, 2.6micrograms daily for pregnant females, and 2.8 micrograms daily for breastfeeding females. Thoseover 50 years of age should meet the RDA by eating foods reinforced with B12 or by takinga vitaminB12 supplement. Meet your daily nutrient intake requirements from the following food sources: liver, red meat, fishand shellfish, milk and dairy products, fortified soy, almond or rice beverages and products, fortifiedcereals ,nutritional yeast and eggs

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Vitamin B12 Deficiency5 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.


Vitamin B12 (cobalamin) is required for normal functioning of brain, nervous and digestive systems, redblood cell formation. It is involved in DNA synthesis, fatty acid and amino acid metabolism. Vitamin B12 canbe only manufactured by bacteria, and generally it can be found in animal food sources. Slight imbalances invitamin B-12 can lead to anemia, fatigue, stomach inflammation, and affect nervous system. No toxic oradverse effects have been associated with large intakes of vitamin B12 from food or supplements in healthypeople. Genetic variants in several genes, including FUT2, MTHFR, MTRR, TCN2, have been linked to levelsof vitamin B12.

VITAMINB12DEFICIENCY

YOU:

10NORMAL


WHATTODO


NATUREVS.NURTURE


GENETICVARIATIONS



rs1801394, rs1801198


rs10515552, rs602662, rs601338







SUMMARY

You may want to consider extra intake of this essential vitamin, compared to the averagepopulation. Dietary sources of riboflavin include: dairy products (such as milk, cheese and yogurt), eggs,enriched or fortified cereals and grains, nuts, lean meats, liver, dark green vegetables (such asasparagus, broccoli, spinach and turnip greens), fish and poultry.Additional risk factors for vitamin B2 imbalances include gluten free diet, and pregnancy.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Vitamin B2 Deficiency2 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 90% of the population and is consideredstatistically risky compared to the general population.


Vitamin B2 (riboflavin) is involved in vital metabolic processes in the body, and is necessary for energyproduction and normal cell function and growth. It is also crucial in helping other B vitamins undergo thechemical changes that make them useful and plays an important role in iron absorption. Emerging researchshows that riboflavin may play a role in cancer prevention as well as helping with migraine headaches. Toolittle riboflavin can cause weakness, throat swelling/soreness, a swollen tongue, skin cracking (includingcracked corners of the mouth), hair loss, dermatitis, and anemia. Riboflavin deficiency can also affect vision,including blurred vision and burning, itching, watering, sore, or bloodshot eyes, as well eyes becoming light-sensitive and easily fatigued. People with some genetic variations need to monitor their vitamin B2 intake.Excess riboflavin is excreted through the urine (often temporarily causing urine to turn a bright yellow colorseveral hours after taking it), and there is no common risk for an overdose.

VITAMINB2DEFICIENCY

YOU:

90ELEVATED


WHATTODO

You may want to consider extra intake of this essential vitamin, compared to the average population. Dietary sources of riboflavin include: dairy products (such as milk, cheese and yogurt), eggs,enriched or fortified cereals and grains, nuts, lean meats, liver, dark green vegetables (such asasparagus, broccoli, spinach and turnip greens), fish and poultry.Additional risk factors for vitamin B2 imbalances include gluten free diet, and pregnancy.Consult a registered dietitian or physician to make sure you are meeting your daily requirements forvitamin B2 intake.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1801394, rs1801133






SUMMARY

You may want to consider slightly higher than average intake of niacin through your diet.The best sources of niacin are beets, brewer's yeast, beef liver, beef kidney, fish such as salmon,swordfish, tuna, sunflower seeds, peanuts.New studies have shown that niacin is beneficial to the skin health, specifically for problemsinvolving pigmentation and dry skin.

MYASSESMENT



Vitamin B3 (niacin or nicotinic acid) is essential for normal functioning of digestive and nervous systems,dealing with oxidative stress, DNA repair, and skin health. It is important in metabolism of fat, carbohydrates,and alcohol. Severe niacin deficiencies are rare, and are usually found in areas of malnutrition. Consumptionof large quantities of alcohol contributes to the risk of niacin deficiencies that can cause nausea, headaches,tiredness, decreased tolerance to cold, dry and inflamed skin. Several genetic variants are associated withincreased risk of niacin imbalances.

WHATTODO

You may want to consider slightly higher than average intake of niacin through your diet.The best sources of niacin are beets, brewer's yeast, beef liver, beef kidney, fish such as salmon,swordfish, tuna, sunflower seeds, peanuts.New studies have shown that niacin is beneficial to the skin health, specifically for problemsinvolving pigmentation and dry skin.Risk factors for vitamin B3 imbalances include depression, neurological disorders, high cholesteroland triglyceride levels, cardiovascular diseases.While niacin has been used to treat several conditions such as high cholesterol, diabetes,atherosclerosis, osteoarthritis and heart disease, niacin at very high doses can be toxic.You should not take niacin supplementation except under your doctor's supervision.

VITAMINB3DEFICIENCY

YOU:

95ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs2230037, rs1050757






SUMMARY

You may want to consider a higher intake of B5 through your diet.Foods rich in vitamin B5 include animal organs (liver and kidney), fish, shellfish, milk products, eggs,avocados, legumes, mushrooms, and sweet potatoes.Higher doses have been shown to help the healing process of skin wounds and lower cholesterol.

MYASSESMENT



Vitamin B5 (Pantothenic acid) is essential to many biochemical reactions in all forms of life (including plantsand animals). Vitamin B5 is required for the breakdown of fats and carbohydrates, maintenance of healthydigestive system, production of red blood cells, sex and stress related hormones. While severe vitamin B5deficiencies are very rare, imbalances may cause fatigue, depression, irritability, nausea, and upperrespiratory infections.

WHATTODO

You may want to consider a higher intake of B5 through your diet.Foods rich in vitamin B5 include animal organs (liver and kidney), fish, shellfish, milk products, eggs,avocados, legumes, mushrooms, and sweet potatoes.Higher doses have been shown to help the healing process of skin wounds and lower cholesterol.Risk factors for vitamin B5 imbalances include depression, stress, and respiratory infections.No upper limit for vitamin B5 has been set.

VITAMINB5DEFICIENCY

YOU:

95ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs7535528, rs12898259






SUMMARY

You may want to consider slightly higher than average vitamin B6 intake from food sources.Vitamin B6 is found in fortified cereals, 100% bran, legumes, meat, poultry, fish, liver, nuts andseeds, blackstrap molasses, bananas, peanut butter, many vegetables, and non-citrus fruit. Variouscommon drugs, including non-steroid anti-inflammatory drugs such as ibuprofen and oralcontraceptives, interfere with vitamin B6 metabolism.Other risk factors for vitamin B6 imbalances include high levels of homocysteine, cardiovascularproblems, asthma, ADHD, cognitive decline.

MYASSESMENT



Vitamin B6 (and its derivative pyridoxal 5'-phosphate, PLP) are involved in numerous essential processes,including protein metabolism, normal functioning of immune and nervous systems, production ofhemoglobin, and maintenance of normal levels of homocysteine. Vitamin B6 together with vitamin B2, B9(folate) and choline, facilitates the methylation cycle which is fundamental to life. Even slight imbalances invitamin B6 levels are linked to various conditions. Symptoms of a vitamin B6 imbalance include nerveinflammation, irritability, depression, dermatitis, cracked and sore lips, inflamed tongue and mouth, andconfusion. Several studies identified genetic variants associated with lower levels of vitamin B6.

VITAMINB6DEFICIENCY

YOU:

75SLIGHTLYELEVATED


WHATTODO

You may want to consider slightly higher than average vitamin B6 intake from food sources.Vitamin B6 is found in fortified cereals, 100% bran, legumes, meat, poultry, fish, liver, nuts andseeds, blackstrap molasses, bananas, peanut butter, many vegetables, and non-citrus fruit. Variouscommon drugs, including non-steroid anti-inflammatory drugs such as ibuprofen and oralcontraceptives, interfere with vitamin B6 metabolism.Other risk factors for vitamin B6 imbalances include high levels of homocysteine, cardiovascularproblems, asthma, ADHD, cognitive decline.Consult a registered dietitian or physician if you are considering B6 supplementation.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1697421, rs1801133, rs1256335, rs4654748, rs567754









SUMMARY

Meet your daily biotin intake requirements based on the daily recommended allowance. Foods such as egg yolk, liver, and whole-grain cereal are rich in biotinRisk factors for biotin imbalances include pregnancy and smoking.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Vitamin B7 DeficiencyNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically low compared to the general population.


Vitamin B7 (or biotin) is required by all organisms. It is important for converting food into glucose, which isused to produce energy, producing fatty acids and amino acids Biotin is essential for the normal function ofthe nervous system as well as the maintenance of normal skin and mucous membranes, activatingmetabolism in the hair roots and fingernail cells. Biotin must be obtained from the diet as it can be onlysynthesized by plants, bacteria, yeast and algae. Genetic variations in biotinidase enzyme are associatedwith lower levels of biotin. Symptoms of biotin imbalance include hair loss, brittle fingernails, fatigue,insomnia, depression.

WHATTODO


VITAMINB7DEFICIENCY

YOU:

25NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY

You may want to consider a higher than average recommended intake to meet your dailyrequirements for folate from food sources.Good dietary sources of folate include: dark green vegetables like spinach, asparagus and broccoli,bananas, strawberries, oranges, tomato juice, legumes, nuts, cereals, organs meats like liver andkidneys.Some foods that are often fortified with folic acid include enriched breads, bagels, cereals, flours,cornmeal, pastas and rice.

MYASSESMENT



Vitamin B9 (folate) is essential for vital processes such as DNA synthesis, methylation, cell repair andmaintenance, protein metabolism, and the formation of blood cells. It is really important for pregnant women,and women trying to conceive. Folic acid and folate are often used interchangeably, but folic acid is the typeof folate found in vitamin supplements and fortified foods. Folate deficiencies are associated with anemia,elevated levels of homocysteine, pregnancy complications, increased risk of cardiovascular diseases.

VITAMINB9DEFICIENCY

YOU:

80ELEVATED


WHATTODO

You may want to consider a higher than average recommended intake to meet your daily requirements forfolate from food sources.

Good dietary sources of folate include: dark green vegetables like spinach, asparagus and broccoli,bananas, strawberries, oranges, tomato juice, legumes, nuts, cereals, organs meats like liver andkidneys.Some foods that are often fortified with folic acid include enriched breads, bagels, cereals, flours,cornmeal, pastas and rice.Common drugs, including nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen), oralcontraceptives, cholesterol lowering and blood pressure control medications may interfere withfolate metabolism.If you are in doubt how to best supplement your folate, consult a registered dietitian or physician. Ifyou are concerned about your MTHFR variants (rs1801133 and rs1801131), please read theprovided references.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1999594, rs1256335, rs1801394, rs1805087, rs4654748, rs2236225, rs234706, rs1801133,rs3733890













SUMMARY

You may want to step-up your intake of vitamin C.Vitamin C can be found in fruits such as oranges, grapefruits, cantaloupes, Kiwi, mango, papaya,pineapple, strawberries, raspberries, blueberries, cranberries and watermelon.Vegetables such as broccoli, Brussels sprouts, cauliflower, green and red peppers, spinach,cabbage, turnip greens, sweet and white potatoes, and tomatoes also have a high vitamin Ccontent.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Vitamin C Deficiency4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically risky compared to the general population.

WHATISVITAMINCDEFICIENCY

Vitamin C (ascorbic acid) is a water-soluble compound that is critical in numerous vital processes. Vitamin Cis essential for normal functioning of immune system, production of red blood cells, healthy connectivetissues, blood vessels, bones, teeth, and gums. It is a powerful antioxidant, and it participates in ironabsorption. While vitamin C deficiencies are rare in developed countries, higher blood levels of vitamin C hasbeen linked to vitality, longevity, lower risk of death from all causes, including cardiovascular diseases andcancer. Vitamin C is commonly taken during winter months to help fight off colds. Humans cannot producevitamin C and must get this essential vitamin on a daily basis. Scientific studies identified several geneticvariations associated with lower levels of vitamin C. If you spend lots of time in the gym, consider boostingyour vitamin C levels. People who suffer a lot from colds , as well as smokers, and heavy drinkers, wouldbenefit from higher intake of vitamin C.

VITAMINCDEFICIENCY

YOU:

65SLIGHTLYELEVATED


WHATTODO

You may want to step-up your intake of vitamin C.Vitamin C can be found in fruits such as oranges, grapefruits, cantaloupes, Kiwi, mango, papaya,pineapple, strawberries, raspberries, blueberries, cranberries and watermelon.Vegetables such as broccoli, Brussels sprouts, cauliflower, green and red peppers, spinach,cabbage, turnip greens, sweet and white potatoes, and tomatoes also have a high vitamin Ccontent.There is a variety of vitamin C supplements available.

NATUREVS.NURTURE


GENETICVARIATIONS



rs74837985, rs6133175, rs12479919, rs113846795








SUMMARY

You may want to consider a higher than average intake of vitamin D compared to the recommendeddaily allowance. Food rich in vitamin D include fatty fish such as tuna, mackerel, trout, herring, sardines, kipper,anchovies, or carp.Vitamin D can also be found in beef liver, cheese, egg yolks, and some mushrooms.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Vitamin D Deficiency13 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISVITAMINDDEFICIENCY

Vitamin D is a fat-soluble vitamin that is critical to bone and muscle health, normal functioning of immune,endocrine and cardiovascular systems. Vitamin D can be synthesized in the skin upon exposure to sunlight:it is metabolized into active form and regulates hundreds of genes by binding to vitamin D receptor (VDR).There is a steady increase in cases of severe vitamin D deficiencies in developed countries, mainly due tosun protection measures. Other factors that contribute to vitamin D deficiency include environmentalconditions (air pollution, geographical locations), as well as dark skin, being over 50, family history ofosteoporosis, excessive weight, and genetics. Large-scale studies identified genetics variants in severalgenes (including the vitamin binding receptor, VDR; vitamin binding protein GC, and NAD coenzyme) thatcontribute to vitamin D deficiencies.

VITAMINDDEFICIENCY

YOU:

95ELEVATED


WHATTODO

You may want to consider a higher than average intake of vitamin D compared to the recommended dailyallowance.

Food rich in vitamin D include fatty fish such as tuna, mackerel, trout, herring, sardines, kipper,anchovies, or carp.Vitamin D can also be found in beef liver, cheese, egg yolks, and some mushrooms.Sun exposure (using proper precautions) is very important as vitamin D gets through the skin intoours bodies. During sunny times, the body can make sufficient vitamin D with just a few minutes aday of midday sun exposure without sunscreen. It is recommended to get at least 15-30 minutes ofunprotected sun exposure 2-4 times a week. Check your skin sun sensitivity reports to assess yourpotential risks of exposure to the UV radiation.An alternative to sun exposure is vitamin D supplementation under the supervision of health careprovider. Have your vitamin D blood levels checked regularly. The correct blood test is 25-OH vitamin D or 25-hydroxy Vitamin D test.

NATUREVS.NURTURE


GENETICVARIATIONS



rs7041, rs1007392, rs1544410, rs7944926, rs3829251, rs731236, rs7975232, rs1993116,rs11234027, rs705117, rs2282679, rs2060793, rs12800438

















SUMMARY

Make sure you meet your daily requirements of vitamin E through food sources.Vitamin E can be found in vegetable oils, nuts, such as peanuts, hazelnuts, and, especially, almonds,seeds like sunflower seeds, avocados, whole grains, wheat germ, and to a lesser extent in greenvegetables, such as spinach and broccoli.Topical application can supply skin with vitamin E forms that are not available from the diet.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Vitamin E Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISVITAMINEDEFICIENCY

Vitamin E is a fat-soluble nutrient that includes eight different naturally occurring compounds (fourtocopherols and four tocotrienols). Vitamin E acts as an antioxidant, helping to protect cells from the damagecaused by free radicals. It is required for normal functioning of immune system, blood vessels and manyother organs in the body. Vitamin E reduces the risk of life-threatening blood clots. Studies showed thathigher levels of vitamin E are beneficial for healthy cardiovascular system, prevention of cataracts, age-related macular degeneration and fatty liver disease. Vitamin E is sometimes used for improving physicalendurance, increasing energy, reducing muscle damage after exercise, and improving muscle strength.Vitamin E is essential for healthy skin, as it has anti-inflammatory and photo-protective properties. Vitamin Eimbalances are relatively common, and caused by diet that does not include sufficient amount of good fats,fat malabsorption disorders, and genetic variations.

WHATTODO


VITAMINEDEFICIENCY

YOU:

30NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs3741920, rs7834588


rs2108622





SUMMARY

Make sure you eat a balanced diet, and include vitamin K-rich foods.Both plant and animal foods can provide us with significant amounts of vitamin K. Vegetable oilssuch as extra virgin olive oil, fresh green vegetables, including spinach, kale, broccoli, lettuce, Swisschard, parsley, are the best source of vitamin K.Eggs, meats and seafood contain measurable amounts of vitamin K2, as do cheeses, yogurts, andfermented soy.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Vitamin K Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 70% of the population and is consideredstatistically low compared to the general population.

WHATISVITAMINKDEFICIENCY

Vitamin K is a group of fat-soluble vitamins (including phylloquinone, or vitamin K1, phytonadione, and K2,menaquinone) that is essential for promoting healthy blood clotting, and healthy bones. Growing body ofresearch indicates that optimum intake of vitamin K contributes to longevity. Vitamin K plays protective roleagainst many modern diseases, including atherosclerosis, osteoporosis, diabetes, and some types ofcancer. Low vitamin K intake increases the risk of excessive bleeding, mineralization of blood vessels, andalso risk of bone fractures. Vitamin K is often used to treat skin to remove spider veins, bruises, scars,stretch marks, burns and it has been known to speed up healing. Genetic variations contribute to vitamin Kimbalances: in fact some variants have been linked to higher levels of circulating phylloquinone levels, whileothers contribute to lower vitamin K levels.

VITAMINKDEFICIENCY

YOU:

70NORMAL


WHATTODO

Make sure you eat a balanced diet, and include vitamin K-rich foods.Both plant and animal foods can provide us with significant amounts of vitamin K. Vegetable oilssuch as extra virgin olive oil, fresh green vegetables, including spinach, kale, broccoli, lettuce, Swisschard, parsley, are the best source of vitamin K.Eggs, meats and seafood contain measurable amounts of vitamin K2, as do cheeses, yogurts, andfermented soy.People taking prescription anticoagulants (such as warfarin) need to monitor their dietary intake ofvitamin K containing foods closely.

NATUREVS.NURTURE


GENETICVARIATIONS



rs8050894, rs7294


rs2108622





SUMMARY

You may want to consider consuming foods that are high in zinc.High-protein foods contain high amounts of zinc. Shellfish, beef, pork, and lamb contain more zincthan fish. The dark meat of a chicken has more zinc than the light meat. Other good sources of zincare seafood, nuts, seeds, whole grains, legumes, and yeast.Vegetarians and vegans are at greater risk for zinc deficiency, because the zinc from plant foods isfour times more difficult to absorb than zinc from meats.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Zinc Deficiency5 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISZINCDEFICIENCY

Zinc is an essential trace mineral that is needed for all forms of life. Zinc is required for many regulatory,catalytic, and structural processes in the body. It plays important role in healthy functioning of immunesystem, wound healing, cell division, and protein synthesis. Zinc is also needed for the senses of smell andtaste. Zinc deficiency has been linked to impaired immune system function, increased colds and infections,diarrhea, loss of appetite, delayed wound healing, hair loss, taste abnormalities, and mental lethargy.Because zinc helps repair damaged tissues and heal wound, it is used in skin care products to treat acneand skin irritations. Several genetic variants have been associated with lower levels of zinc.

ZINCDEFICIENCY

YOU:

95ELEVATED


WHATTODO

You may want to consider consuming foods that are high in zinc.High-protein foods contain high amounts of zinc. Shellfish, beef, pork, and lamb contain more zincthan fish. The dark meat of a chicken has more zinc than the light meat. Other good sources of zincare seafood, nuts, seeds, whole grains, legumes, and yeast.Vegetarians and vegans are at greater risk for zinc deficiency, because the zinc from plant foods isfour times more difficult to absorb than zinc from meats.Antibiotics as well as diuretics including caffeine and alcohol may interfere with zinc levels.If you suffer from acne, or skin irritations, look for skin care products that contain zinc.If you consider zinc supplementation, remember that too much zinc can be as dangerous as itsdeficiency. Always follow recommendations of your health practitioner.

NATUREVS.NURTURE


GENETICVARIATIONS



rs17811680, rs4886670, rs12906126, rs8040372, rs12898259









Vitamins allow your body to grow and develop. They also play important roles in bodily functions such asmetabolism, immunity and digestion. We test for 17 essential vitamins, including vitamins A, C, D, E, and Kand B vitamins such as riboflavin and folate. Gain insights into how your genetic variations may influencehow your body processes and absorbs vitamins.

VitaminReports17 Reports in 2 groups

BVitaminsB vitamins help the process your body uses to get or make energy from the food youeat. They also help form red blood cells. You can get B vitamins from proteins such asfish, poultry, meat, eggs, and dairy products. Leafy green vegetables, beans, and peasalso have B vitamins. Many cereals and some breads have added B vitamins.

In this group you find about your B Vitamin balance and predispositions to any vitamindeficiency.

OtherVitaminsThis group provide insights to your predispositions for vitamin A, C, D, E, K and more.


SUMMARY


MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Choline Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 60% of the population and is consideredstatistically low compared to the general population.

WHATISCHOLINEDEFICIENCY

Choline is a water-soluble essential micronutrient. It is not actually considered a mineral, and it is usuallygrouped within the B-complex vitamins. Choline is a methyl donor and it is involved in many key processes,including methylation reactions, lipid transport, maintenance of the structural integrity of cell membranes,nerve signaling, and metabolism. Choline is vital for regulation of homocysteine levels, and normal brainfunctioning. As the liver and the muscles are the major organs for methyl group metabolism, cholinedeficiency causes muscle damage and abnormal deposition of fat in the liver, which may result in a conditioncalled nonalcoholic fatty liver disease. Choline can be made de novo in the body in small amounts but itmust largely be consumed in the diet for optimal health. Endurance athletes and bodybuilders may be athigher risk for choline deficiency. People who drink a lot of alcohol are prone to lower levels of choline.Studies recommend to increase choline intake during pregnancy and breastfeeding.

WHATTODO


CHOLINEDEFICIENCY

YOU:

60NORMAL


NATUREVS.NURTURE


LEARNMORE

Learn more about Choline Deficiency by checking out the following articles:

WebMD on Choline ALL About Choline

GENETICVARIATIONS



rs4646365, rs4646406, rs2236225



http://www.webmd.com/vitamins-supplements/ingredientmono-436-choline.aspx

http://lpi.oregonstate.edu/mic/other-nutrients/choline





SUMMARY

Aim at intake of at least 8 milligrams of LZ. According to a study from Harvard University leads toover 40% lower risk for macular degeneration. This is needed to maintain your healthy vision.Eat the leafy and cruciferous vegetables of yellow, orange and green colors to get Lutein andzeaxanthin (LZ). Lutein is absorbed better when ingested with a small amount of fat, such as olive oilConsume all varieties of cooked summer and winter squash, peas, yellow corn, beet greens,pumpkin, Brussels sprouts, broccoli, romaine and iceberg lettuce, asparagus and carrots. These aregood food sources of LZ and contain between 1 to 4 milligrams of LZ per serving

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Lutein And Zeaxanthin Deficiency2 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 80% of the population and is consideredstatistically risky compared to the general population.

WHATISLUTEINANDZEAXANTHINDEFICIENCY

Lutein and zeaxanthin (LZ) are yellow to red xanthophylls, a type of naturally occurring carotenoids. They arefound in high concentrations in the macula of the human eye. In fact, the small yellowish area of the eyeretina near the optic disk that provides central vision, is called the "macula lutea", from the Latin macula(spot) and lutea (yellow). Lutein and zeaxanthin block blue light from reaching the underlying structures in theretina, reducing the risk of light-induced oxidative damage that could lead to macular degeneration andcataracts, which are the leading causes of visual impairment and acquired blindness. Lutein and zeaxanthinalso have important general antioxidant functions in the body. Along with other natural antioxidants,including vitamin C, beta carotene and vitamin E, they guard the body from damaging effects of free radicals.Lutein may also contribute to protection against atherosclerosis (buildup of fatty deposits in arteries), thedisease that leads to most heart attacks.

LUTEINANDZEAXANTHINDEFICIENCY

YOU:

80SLIGHTLYELEVATED


WHATTODO

Aim at intake of at least 8 milligrams of LZ. According to a study from Harvard University leads to over 40%lower risk for macular degeneration. This is needed to maintain your healthy vision.

Eat the leafy and cruciferous vegetables of yellow, orange and green colors to get Lutein andzeaxanthin (LZ). Lutein is absorbed better when ingested with a small amount of fat, such as olive oilConsume all varieties of cooked summer and winter squash, peas, yellow corn, beet greens,pumpkin, Brussels sprouts, broccoli, romaine and iceberg lettuce, asparagus and carrots. These aregood food sources of LZ and contain between 1 to 4 milligrams of LZ per servingInclude other sources of LZ: eggs, orange juice, corn, and other foods with yellow colorIf you consider LZ supplementation, discuss with your health care provider

NATUREVS.NURTURE


LEARNMORE

Learn more about Lutein And Zeaxanthin Deficiency by checking out the following articles:

Pigments in Colorful Vegetables May Ward off Macular Degeneration What is Lutein? Î±-Carotene, Î²-Carotene, Î²-Cryptoxanthin, Lycopene, Lutein, and Zeaxanthin

GENETICVARIATIONS



rs7755, rs6564851



http://www.hsph.harvard.edu/news/hsph-in-the-news/pigments-in-colorful-vegetables-may-ward-off-macular-degeneration/

https://www.nlm.nih.gov/medlineplus/druginfo/natural/754.html





SUMMARY

Meet your lycopene intake requirements from your diet: think cooked tomatoes (fresh tomato pastasauce, tomato juice, tomato soup, paste). Tomatoes account for more than 85% of the dietary intakeof lycopene in North American diets.Cook tomatoes with olive oil or other good fats as lycopene from cooked tomatoes is absorbed 2.5times better than from fresh tomatoes. To protect skin from sun damage, the Mayo clinicrecommends taking 55 grams of tomato paste in olive oil. This provides 16 milligrams of lycopeneInclude watermelons, guava, papaya, pink grapefruit in your diet, in particular if you happen to notlike tomatoes, or are allergic to them

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Lycopene Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 45% of the population and is consideredstatistically low compared to the general population.

WHATISLYCOPENEDEFICIENCY

Lycopene is a bright red carotene, and it gives many fruits and vegetables (tomatoes, watermelons, papayas,pink grapefruits, red carrots) their red color. Lycopene is the most powerful antioxidant that is commonlyfound in the diet: it has a high capacity to remove free radicals. It also helps to protect the skin from thedamage by sunlight. Lycopene is present at higher levels in skin, liver, lungs, prostate, colon and adrenalglands. Scientific studies have linked higher consumption of lycopene rich foods with reduced risk of variousdiseases, including cardiovascular disease, asthma, some cancers, and age-related vision problems.Lycopene has not got an official status of an essential nutrient. Nevertheless, it is widely consideredbeneficial for immune system, skin and eye health.

LYCOPENEDEFICIENCY

YOU:

45NORMAL


WHATTODO

Meet your lycopene intake requirements from your diet: think cooked tomatoes (fresh tomato pasta sauce,tomato juice, tomato soup, paste). Tomatoes account for more than 85% of the dietary intake of lycopene inNorth American diets.

Cook tomatoes with olive oil or other good fats as lycopene from cooked tomatoes is absorbed 2.5times better than from fresh tomatoes. To protect skin from sun damage, the Mayo clinicrecommends taking 55 grams of tomato paste in olive oil. This provides 16 milligrams of lycopeneInclude watermelons, guava, papaya, pink grapefruit in your diet, in particular if you happen to notlike tomatoes, or are allergic to themConsider lycopene supplementation. The lycopene from the supplements is about as easy for thebody to absorb as dietary lycopene. The Mayo clinic recommends taking lycopene supplementationfor various conditions and concerns, including heart diseases, blood pressure, infertility, and as ageneral antioxidant.

NATUREVS.NURTURE


LEARNMORE

Learn more about Lycopene Deficiency by checking out the following articles:

Intorduction to Lycopene by Mayo Clinic What is Lycopene Everything about Carotenoids

http://www.mayoclinic.org/drugs-supplements/lycopene/dosing/hrb-20059666

https://medlineplus.gov/druginfo/natural/554.html



GENETICVARIATIONS



rs6564851, rs7680948, rs12934922







SUMMARY

Meet your daily nutrient intake requirements for carotenoidsVitamin A is included in most multivitamins, and the U.S. recommended dietary allowance (RDA) foradults is as follows: 900 micrograms daily (3,000 IU) for men and 700 micrograms daily (2,300 IU) forwomen; for pregnant women 19 years old and older, 770 micrograms daily (2,600 IU); and forlactating women 19 years old and older, 1,300 micrograms daily (4,300 IU). (Source: May Clinic) Best carotenoid-rich foods are sweet potatoes, carrots, broccoli, kale, spinach, pumpkin, collardgreens, apricot, papaya, mango, peas, tomatoes, cheddar cheese and eggs

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Vitamin A (Carotene) Deficiency2 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 40% of the population and is consideredstatistically low compared to the general population.

WHATISVITAMINA(CAROTENE)DEFICIENCY

Vitamin A, the group of fat-soluble vitamins, is essential for immune system functioning, reproduction,healthy vision, maintenance of strong bones and teeth, red blood cell production, tissue repair and skinhealth. Vitamin A comes in two forms: biologically active form, retinol, and pro-vitamin A carotenoids(including alpha- and beta-carotenes) that are converted into retinol. Carotenoids are important antioxidantsand anti-inflammatory agents, and have tremendous protective benefits for heart conditions, respiratoryproblems, elevated glucose levels, and various other ailments. Alpha and beta-carotenes contribute to skinand hair health. Humans cannot produce carotenoids themselves and therefore need it directly from foodsources. Carotenoids come from plant sources. Carotenoid-rich foods are often, but not always, haveorange, bright red, or yellow colors. In fact, the word carotene comes from the Latin word for carrot. Geneticvariants in CD36 and SCARB1 genes have been linked to lower levels of beta-carotene.

VITAMINA(CAROTENE)DEFICIENCY

YOU:

40NORMAL


WHATTODO

Meet your daily nutrient intake requirements for carotenoidsVitamin A is included in most multivitamins, and the U.S. recommended dietary allowance (RDA) foradults is as follows: 900 micrograms daily (3,000 IU) for men and 700 micrograms daily (2,300 IU) forwomen; for pregnant women 19 years old and older, 770 micrograms daily (2,600 IU); and forlactating women 19 years old and older, 1,300 micrograms daily (4,300 IU). (Source: May Clinic) Best carotenoid-rich foods are sweet potatoes, carrots, broccoli, kale, spinach, pumpkin, collardgreens, apricot, papaya, mango, peas, tomatoes, cheddar cheese and eggsCarotenoids need to be consumed with a fat for the body to absorb them: cook carotenoid-containing vegetables in oil

NATUREVS.NURTURE


GENETICVARIATIONS



rs17263407, rs1984112






SUMMARY

Optimize your retinol intakeBest retinol-rich foods include animal liver, egg yolks, butter and heavy creamIf you a pregnant or nursing woman; or/and vegetarian/vegan, you are under higher risk of retinoldeficiency, and you need to make sure you are meeting your daily requirements for this essentialvitamin

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Vitamin A (Retinol) Deficiency4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 70% of the population and is consideredstatistically risky compared to the general population.

WHATISVITAMINA(RETINOL)DEFICIENCY

Vitamin A, the group of fat-soluble vitamins, is essential for immune system functioning, reproduction,healthy vision, maintenance of strong bones and teeth, red blood cell production, tissue repair and skinhealth. Vitamin A comes in two forms: biologically active form, retinol, and pro-vitamin A carotenoids(including beta-carotene, lutein, lycopene) that need to be converted into retinol to be useful in the body.Carotenoids come from plant sources, while retinol comes from animal sources. Some specific immune,inflammatory, genetic, and reproductive-related benefits of vitamin A can only be obtained from the retinoidforms of the vitamin A. These retinoid forms can be especially important with respect to pregnancy andchildbirth, infancy, childhood growth, and resistance to infectious disease. Plasma retinol levels do notdecline until liver vitamin A sources are almost depleted and thus do not accurately reflect retinol imbalance.Studies show that variations in several key genes in retinol metabolism pathway impair the conversion ofcarotenoids to retinol, increase breakdown, or decrease absorption of retinoic acid, therefore affecting thelevels of retinol.

VITAMINA(RETINOL)DEFICIENCY

YOU:

70SLIGHTLYELEVATED


WHATTODO

Optimize your retinol intakeBest retinol-rich foods include animal liver, egg yolks, butter and heavy creamIf you a pregnant or nursing woman; or/and vegetarian/vegan, you are under higher risk of retinoldeficiency, and you need to make sure you are meeting your daily requirements for this essentialvitaminIf you consider retinol supplementation, consult a doctor or a registered dietitian

NATUREVS.NURTURE


GENETICVARIATIONS



rs10882272, rs6564851, rs6420424, rs12934922








SUMMARY

You may benefit from slightly extra intake of thiamine above the recommended daily allowance. Make sure you meet your daily requirement for thiamine through your diet.Adults (18 years and older) The following doses are the U.S. recommended daily allowance (RDA)of thiamine taken by mouth: in adults 19 and older, 1.2 milligrams for males and 1.1 milligrams forfemales; and in pregnant or breastfeeding women of any age, 1.4 milligrams. The best sources of thiamin include yeast extract, pork, fortified breakfast cereals, enriched grainproducts and soy products.

MYASSESMENT



Vitamin B1 (Thiamine), the first vitamin B that was discovered, is sometimes called anti-stress vitamin as itimproves body`s ability to withstand stress, strengthens the immune system, fights depression and assistshealthy functioning of the nervous system. Thiamine is involved in several enzyme functions associated withthe metabolism of carbohydrates, and fatty acids. Severe thiamine deficiencies are rare (except in critically illpeople and alcoholics) and they are associated with genetic diseases such as maple syrup urine disease andberiberi. Thiamine imbalances can result from poor dietary intake, reduced gastrointestinal absorption,increased metabolic requirements, or excessive loss of thiamin due to genetic variations.

VITAMINB1DEFICIENCY

YOU:

65SLIGHTLYELEVATED


WHATTODO

You may benefit from slightly extra intake of thiamine above the recommended daily allowance. Make sureyou meet your daily requirement for thiamine through your diet.

Adults (18 years and older) The following doses are the U.S. recommended daily allowance (RDA)of thiamine taken by mouth: in adults 19 and older, 1.2 milligrams for males and 1.1 milligrams forfemales; and in pregnant or breastfeeding women of any age, 1.4 milligrams. The best sources of thiamin include yeast extract, pork, fortified breakfast cereals, enriched grainproducts and soy products.Additional risk factors include gluten free and low gluten diet, depression, stress, and excessivealcohol consumption.Consult your healthcare provider if you consider thiamine supplementation.

NATUREVS.NURTURE


GENETICVARIATIONS



rs11691652





SUMMARY


MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Vitamin B12 Deficiency5 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 10% of the population and is consideredstatistically low compared to the general population.


Vitamin B12 (cobalamin) is required for normal functioning of brain, nervous and digestive systems, redblood cell formation. It is involved in DNA synthesis, fatty acid and amino acid metabolism. Vitamin B12 canbe only manufactured by bacteria, and generally it can be found in animal food sources. Slight imbalances invitamin B-12 can lead to anemia, fatigue, stomach inflammation, and affect nervous system. No toxic oradverse effects have been associated with large intakes of vitamin B12 from food or supplements in healthypeople. Genetic variants in several genes, including FUT2, MTHFR, MTRR, TCN2, have been linked to levelsof vitamin B12.

VITAMINB12DEFICIENCY

YOU:

10NORMAL


WHATTODO


NATUREVS.NURTURE


GENETICVARIATIONS



rs1801394, rs1801198


rs10515552, rs602662, rs601338







SUMMARY

You may want to consider extra intake of this essential vitamin, compared to the averagepopulation. Dietary sources of riboflavin include: dairy products (such as milk, cheese and yogurt), eggs,enriched or fortified cereals and grains, nuts, lean meats, liver, dark green vegetables (such asasparagus, broccoli, spinach and turnip greens), fish and poultry.Additional risk factors for vitamin B2 imbalances include gluten free diet, and pregnancy.

MYASSESMENT



Vitamin B2 (riboflavin) is involved in vital metabolic processes in the body, and is necessary for energyproduction and normal cell function and growth. It is also crucial in helping other B vitamins undergo thechemical changes that make them useful and plays an important role in iron absorption. Emerging researchshows that riboflavin may play a role in cancer prevention as well as helping with migraine headaches. Toolittle riboflavin can cause weakness, throat swelling/soreness, a swollen tongue, skin cracking (includingcracked corners of the mouth), hair loss, dermatitis, and anemia. Riboflavin deficiency can also affect vision,including blurred vision and burning, itching, watering, sore, or bloodshot eyes, as well eyes becoming light-sensitive and easily fatigued. People with some genetic variations need to monitor their vitamin B2 intake.Excess riboflavin is excreted through the urine (often temporarily causing urine to turn a bright yellow colorseveral hours after taking it), and there is no common risk for an overdose.

VITAMINB2DEFICIENCY

YOU:

90ELEVATED


WHATTODO

You may want to consider extra intake of this essential vitamin, compared to the average population. Dietary sources of riboflavin include: dairy products (such as milk, cheese and yogurt), eggs,enriched or fortified cereals and grains, nuts, lean meats, liver, dark green vegetables (such asasparagus, broccoli, spinach and turnip greens), fish and poultry.Additional risk factors for vitamin B2 imbalances include gluten free diet, and pregnancy.Consult a registered dietitian or physician to make sure you are meeting your daily requirements forvitamin B2 intake.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1801394, rs1801133






SUMMARY

You may want to consider slightly higher than average intake of niacin through your diet.The best sources of niacin are beets, brewer's yeast, beef liver, beef kidney, fish such as salmon,swordfish, tuna, sunflower seeds, peanuts.New studies have shown that niacin is beneficial to the skin health, specifically for problemsinvolving pigmentation and dry skin.

MYASSESMENT



Vitamin B3 (niacin or nicotinic acid) is essential for normal functioning of digestive and nervous systems,dealing with oxidative stress, DNA repair, and skin health. It is important in metabolism of fat, carbohydrates,and alcohol. Severe niacin deficiencies are rare, and are usually found in areas of malnutrition. Consumptionof large quantities of alcohol contributes to the risk of niacin deficiencies that can cause nausea, headaches,tiredness, decreased tolerance to cold, dry and inflamed skin. Several genetic variants are associated withincreased risk of niacin imbalances.

WHATTODO

You may want to consider slightly higher than average intake of niacin through your diet.The best sources of niacin are beets, brewer's yeast, beef liver, beef kidney, fish such as salmon,swordfish, tuna, sunflower seeds, peanuts.New studies have shown that niacin is beneficial to the skin health, specifically for problemsinvolving pigmentation and dry skin.Risk factors for vitamin B3 imbalances include depression, neurological disorders, high cholesteroland triglyceride levels, cardiovascular diseases.While niacin has been used to treat several conditions such as high cholesterol, diabetes,atherosclerosis, osteoarthritis and heart disease, niacin at very high doses can be toxic.You should not take niacin supplementation except under your doctor's supervision.

VITAMINB3DEFICIENCY

YOU:

95ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs2230037, rs1050757






SUMMARY

You may want to consider a higher intake of B5 through your diet.Foods rich in vitamin B5 include animal organs (liver and kidney), fish, shellfish, milk products, eggs,avocados, legumes, mushrooms, and sweet potatoes.Higher doses have been shown to help the healing process of skin wounds and lower cholesterol.

MYASSESMENT



Vitamin B5 (Pantothenic acid) is essential to many biochemical reactions in all forms of life (including plantsand animals). Vitamin B5 is required for the breakdown of fats and carbohydrates, maintenance of healthydigestive system, production of red blood cells, sex and stress related hormones. While severe vitamin B5deficiencies are very rare, imbalances may cause fatigue, depression, irritability, nausea, and upperrespiratory infections.

WHATTODO

You may want to consider a higher intake of B5 through your diet.Foods rich in vitamin B5 include animal organs (liver and kidney), fish, shellfish, milk products, eggs,avocados, legumes, mushrooms, and sweet potatoes.Higher doses have been shown to help the healing process of skin wounds and lower cholesterol.Risk factors for vitamin B5 imbalances include depression, stress, and respiratory infections.No upper limit for vitamin B5 has been set.

VITAMINB5DEFICIENCY

YOU:

95ELEVATED


NATUREVS.NURTURE


GENETICVARIATIONS



rs7535528, rs12898259






SUMMARY

You may want to consider slightly higher than average vitamin B6 intake from food sources.Vitamin B6 is found in fortified cereals, 100% bran, legumes, meat, poultry, fish, liver, nuts andseeds, blackstrap molasses, bananas, peanut butter, many vegetables, and non-citrus fruit. Variouscommon drugs, including non-steroid anti-inflammatory drugs such as ibuprofen and oralcontraceptives, interfere with vitamin B6 metabolism.Other risk factors for vitamin B6 imbalances include high levels of homocysteine, cardiovascularproblems, asthma, ADHD, cognitive decline.

MYASSESMENT



Vitamin B6 (and its derivative pyridoxal 5'-phosphate, PLP) are involved in numerous essential processes,including protein metabolism, normal functioning of immune and nervous systems, production ofhemoglobin, and maintenance of normal levels of homocysteine. Vitamin B6 together with vitamin B2, B9(folate) and choline, facilitates the methylation cycle which is fundamental to life. Even slight imbalances invitamin B6 levels are linked to various conditions. Symptoms of a vitamin B6 imbalance include nerveinflammation, irritability, depression, dermatitis, cracked and sore lips, inflamed tongue and mouth, andconfusion. Several studies identified genetic variants associated with lower levels of vitamin B6.

VITAMINB6DEFICIENCY

YOU:

75SLIGHTLYELEVATED


WHATTODO

You may want to consider slightly higher than average vitamin B6 intake from food sources.Vitamin B6 is found in fortified cereals, 100% bran, legumes, meat, poultry, fish, liver, nuts andseeds, blackstrap molasses, bananas, peanut butter, many vegetables, and non-citrus fruit. Variouscommon drugs, including non-steroid anti-inflammatory drugs such as ibuprofen and oralcontraceptives, interfere with vitamin B6 metabolism.Other risk factors for vitamin B6 imbalances include high levels of homocysteine, cardiovascularproblems, asthma, ADHD, cognitive decline.Consult a registered dietitian or physician if you are considering B6 supplementation.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1697421, rs1801133, rs1256335, rs4654748, rs567754









SUMMARY


MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Vitamin B7 DeficiencyNo variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 25% of the population and is consideredstatistically low compared to the general population.


Vitamin B7 (or biotin) is required by all organisms. It is important for converting food into glucose, which isused to produce energy, producing fatty acids and amino acids Biotin is essential for the normal function ofthe nervous system as well as the maintenance of normal skin and mucous membranes, activatingmetabolism in the hair roots and fingernail cells. Biotin must be obtained from the diet as it can be onlysynthesized by plants, bacteria, yeast and algae. Genetic variations in biotinidase enzyme are associatedwith lower levels of biotin. Symptoms of biotin imbalance include hair loss, brittle fingernails, fatigue,insomnia, depression.

WHATTODO


VITAMINB7DEFICIENCY

YOU:

25NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS







SUMMARY

You may want to consider a higher than average recommended intake to meet your dailyrequirements for folate from food sources.Good dietary sources of folate include: dark green vegetables like spinach, asparagus and broccoli,bananas, strawberries, oranges, tomato juice, legumes, nuts, cereals, organs meats like liver andkidneys.Some foods that are often fortified with folic acid include enriched breads, bagels, cereals, flours,cornmeal, pastas and rice.

MYASSESMENT



Vitamin B9 (folate) is essential for vital processes such as DNA synthesis, methylation, cell repair andmaintenance, protein metabolism, and the formation of blood cells. It is really important for pregnant women,and women trying to conceive. Folic acid and folate are often used interchangeably, but folic acid is the typeof folate found in vitamin supplements and fortified foods. Folate deficiencies are associated with anemia,elevated levels of homocysteine, pregnancy complications, increased risk of cardiovascular diseases.

VITAMINB9DEFICIENCY

YOU:

80ELEVATED


WHATTODO

You may want to consider a higher than average recommended intake to meet your daily requirements forfolate from food sources.

Good dietary sources of folate include: dark green vegetables like spinach, asparagus and broccoli,bananas, strawberries, oranges, tomato juice, legumes, nuts, cereals, organs meats like liver andkidneys.Some foods that are often fortified with folic acid include enriched breads, bagels, cereals, flours,cornmeal, pastas and rice.Common drugs, including nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen), oralcontraceptives, cholesterol lowering and blood pressure control medications may interfere withfolate metabolism.If you are in doubt how to best supplement your folate, consult a registered dietitian or physician. Ifyou are concerned about your MTHFR variants (rs1801133 and rs1801131), please read theprovided references.

NATUREVS.NURTURE


GENETICVARIATIONS



rs1999594, rs1256335, rs1801394, rs1805087, rs4654748, rs2236225, rs234706, rs1801133,rs3733890













SUMMARY

You may want to step-up your intake of vitamin C.Vitamin C can be found in fruits such as oranges, grapefruits, cantaloupes, Kiwi, mango, papaya,pineapple, strawberries, raspberries, blueberries, cranberries and watermelon.Vegetables such as broccoli, Brussels sprouts, cauliflower, green and red peppers, spinach,cabbage, turnip greens, sweet and white potatoes, and tomatoes also have a high vitamin Ccontent.

MYASSESMENT

You seem to have slightly elevated genetic predispositions risk for Vitamin C Deficiency4 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 65% of the population and is consideredstatistically risky compared to the general population.

WHATISVITAMINCDEFICIENCY

Vitamin C (ascorbic acid) is a water-soluble compound that is critical in numerous vital processes. Vitamin Cis essential for normal functioning of immune system, production of red blood cells, healthy connectivetissues, blood vessels, bones, teeth, and gums. It is a powerful antioxidant, and it participates in ironabsorption. While vitamin C deficiencies are rare in developed countries, higher blood levels of vitamin C hasbeen linked to vitality, longevity, lower risk of death from all causes, including cardiovascular diseases andcancer. Vitamin C is commonly taken during winter months to help fight off colds. Humans cannot producevitamin C and must get this essential vitamin on a daily basis. Scientific studies identified several geneticvariations associated with lower levels of vitamin C. If you spend lots of time in the gym, consider boostingyour vitamin C levels. People who suffer a lot from colds , as well as smokers, and heavy drinkers, wouldbenefit from higher intake of vitamin C.

VITAMINCDEFICIENCY

YOU:

65SLIGHTLYELEVATED


WHATTODO

You may want to step-up your intake of vitamin C.Vitamin C can be found in fruits such as oranges, grapefruits, cantaloupes, Kiwi, mango, papaya,pineapple, strawberries, raspberries, blueberries, cranberries and watermelon.Vegetables such as broccoli, Brussels sprouts, cauliflower, green and red peppers, spinach,cabbage, turnip greens, sweet and white potatoes, and tomatoes also have a high vitamin Ccontent.There is a variety of vitamin C supplements available.

NATUREVS.NURTURE


GENETICVARIATIONS



rs74837985, rs6133175, rs12479919, rs113846795








SUMMARY

You may want to consider a higher than average intake of vitamin D compared to the recommendeddaily allowance. Food rich in vitamin D include fatty fish such as tuna, mackerel, trout, herring, sardines, kipper,anchovies, or carp.Vitamin D can also be found in beef liver, cheese, egg yolks, and some mushrooms.

MYASSESMENT

You seem to have elevated genetic predispositions risk for Vitamin D Deficiency13 variations found in your genes for this trait.Your overall predisposition score for this trait is higher than 95% of the population and is consideredstatistically risky compared to the general population.

WHATISVITAMINDDEFICIENCY

Vitamin D is a fat-soluble vitamin that is critical to bone and muscle health, normal functioning of immune,endocrine and cardiovascular systems. Vitamin D can be synthesized in the skin upon exposure to sunlight:it is metabolized into active form and regulates hundreds of genes by binding to vitamin D receptor (VDR).There is a steady increase in cases of severe vitamin D deficiencies in developed countries, mainly due tosun protection measures. Other factors that contribute to vitamin D deficiency include environmentalconditions (air pollution, geographical locations), as well as dark skin, being over 50, family history ofosteoporosis, excessive weight, and genetics. Large-scale studies identified genetics variants in severalgenes (including the vitamin binding receptor, VDR; vitamin binding protein GC, and NAD coenzyme) thatcontribute to vitamin D deficiencies.

VITAMINDDEFICIENCY

YOU:

95ELEVATED


WHATTODO

You may want to consider a higher than average intake of vitamin D compared to the recommended dailyallowance.

Food rich in vitamin D include fatty fish such as tuna, mackerel, trout, herring, sardines, kipper,anchovies, or carp.Vitamin D can also be found in beef liver, cheese, egg yolks, and some mushrooms.Sun exposure (using proper precautions) is very important as vitamin D gets through the skin intoours bodies. During sunny times, the body can make sufficient vitamin D with just a few minutes aday of midday sun exposure without sunscreen. It is recommended to get at least 15-30 minutes ofunprotected sun exposure 2-4 times a week. Check your skin sun sensitivity reports to assess yourpotential risks of exposure to the UV radiation.An alternative to sun exposure is vitamin D supplementation under the supervision of health careprovider. Have your vitamin D blood levels checked regularly. The correct blood test is 25-OH vitamin D or 25-hydroxy Vitamin D test.

NATUREVS.NURTURE


GENETICVARIATIONS



rs7041, rs1007392, rs1544410, rs7944926, rs3829251, rs731236, rs7975232, rs1993116,rs11234027, rs705117, rs2282679, rs2060793, rs12800438

















SUMMARY


MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Vitamin E Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 30% of the population and is consideredstatistically low compared to the general population.

WHATISVITAMINEDEFICIENCY

Vitamin E is a fat-soluble nutrient that includes eight different naturally occurring compounds (fourtocopherols and four tocotrienols). Vitamin E acts as an antioxidant, helping to protect cells from the damagecaused by free radicals. It is required for normal functioning of immune system, blood vessels and manyother organs in the body. Vitamin E reduces the risk of life-threatening blood clots. Studies showed thathigher levels of vitamin E are beneficial for healthy cardiovascular system, prevention of cataracts, age-related macular degeneration and fatty liver disease. Vitamin E is sometimes used for improving physicalendurance, increasing energy, reducing muscle damage after exercise, and improving muscle strength.Vitamin E is essential for healthy skin, as it has anti-inflammatory and photo-protective properties. Vitamin Eimbalances are relatively common, and caused by diet that does not include sufficient amount of good fats,fat malabsorption disorders, and genetic variations.

WHATTODO


VITAMINEDEFICIENCY

YOU:

30NORMAL


NATUREVS.NURTURE


GENETICVARIATIONS



rs3741920, rs7834588


rs2108622





SUMMARY

Make sure you eat a balanced diet, and include vitamin K-rich foods.Both plant and animal foods can provide us with significant amounts of vitamin K. Vegetable oilssuch as extra virgin olive oil, fresh green vegetables, including spinach, kale, broccoli, lettuce, Swisschard, parsley, are the best source of vitamin K.Eggs, meats and seafood contain measurable amounts of vitamin K2, as do cheeses, yogurts, andfermented soy.

MYASSESMENT

Good News! You seem to have low genetic predispositions risk for Vitamin K Deficiency3 variations found in your genes for this trait.Your overall predisposition score for this trait is lower than 70% of the population and is consideredstatistically low compared to the general population.

WHATISVITAMINKDEFICIENCY

Vitamin K is a group of fat-soluble vitamins (including phylloquinone, or vitamin K1, phytonadione, and K2,menaquinone) that is essential for promoting healthy blood clotting, and healthy bones. Growing body ofresearch indicates that optimum intake of vitamin K contributes to longevity. Vitamin K plays protective roleagainst many modern diseases, including atherosclerosis, osteoporosis, diabetes, and some types ofcancer. Low vitamin K intake increases the risk of excessive bleeding, mineralization of blood vessels, andalso risk of bone fractures. Vitamin K is often used to treat skin to remove spider veins, bruises, scars,stretch marks, burns and it has been known to speed up healing. Genetic variations contribute to vitamin Kimbalances: in fact some variants have been linked to higher levels of circulating phylloquinone levels, whileothers contribute to lower vitamin K levels.

VITAMINKDEFICIENCY

YOU:

70NORMAL


WHATTODO

Make sure you eat a balanced diet, and include vitamin K-rich foods.Both plant and animal foods can provide us with significant amounts of vitamin K. Vegetable oilssuch as extra virgin olive oil, fresh green vegetables, including spinach, kale, broccoli, lettuce, Swisschard, parsley, are the best source of vitamin K.Eggs, meats and seafood contain measurable amounts of vitamin K2, as do cheeses, yogurts, andfermented soy.People taking prescription anticoagulants (such as warfarin) need to monitor their dietary intake ofvitamin K containing foods closely.

NATUREVS.NURTURE


GENETICVARIATIONS



rs8050894, rs7294


rs2108622




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