do you have bacteria and viruses covered

8/10/2019 Do You Have Bacteria and Viruses Covered

1/4

Do you have both viruses & bacteria

COVERED?Titanium5+ PH-MSingle-vaccine solution protects against

BRD-causing viruses & bacteria at every stage of production

Bacteria Viruses

M. haemolyticaP. multocida BVD (1 & 2) IBR PI3BRSV


2/4

Managing the BRD complex enhance immunity;reduce exposure to disease

The many factors affecting a calfs ability to contract BRD can be grouped intothree categories that interact with one another: the infectious pathogens, theenvironment and the status of the calf. While some of these factors are withinour control, many are not.

Thats why your veterinarian uses best management practices and preventivemeasures, including vaccinations, to enhance the animals immune system.

Disease prevention can best be described as a two-pronged approach: Increase the animals ability to overcome disease challenges throughvaccination, which builds a stronger immune system

Lower the level of exposure to disease through best management practices this is especially critical during stressful events (e.g., weaning,transporting, commingling)

Titanium 5 + PH-M delivers a broad immune response against the bacteria and viruses most associated

with bovine respiratory disease (BRD) in a single vaccine for cattle as young as 2 months of age.1-4

Calfstatus

Environment

Pathogen

immune system nutrition stress

climate air management

bacteria viruses toxins

BRD is still your No. 1 profit robber BRD accounts for 75 percent of feedlot morbidity, and

50 to 75 percent of mortality, costing the industry anestimated $800 to $900 million annually5-8

BRD-related factors also contribute to a reduction inaverage daily gain by as much as 0.3 to 0.5 lbs9,10

Viruses and bacteria a powerful one-two punch on the immune system

While respiratory viruses can cause BRD on their own, they also can compromise the immunesystem that normally protects cattle against bacteria, allowing bacteria to attack their host and

cause severe cases of BRD. When cattle are exposed to respiratory viruses such as bovine viral diarrhea (BVD),parainfluenza3(PI3), infectious bovine rhinotracheitis (IBR) and bovine respiratory syncytialvirus (BRSV) their immune system can be weakened

Once the immune system is compromised, bacteria including Mannheimia haemolytica andPasteurella multocidacan more easily go deeper into the respiratory tract where theycause disease

When bacterial pathogens reach the lungs, they are a major cause of severe BRD, causingincreased morbidity, mortality, and labor and treatment costs

And what about subclinical cases? One studyshowed that 68 percent of untreated calves hadpulmonary lesions at slaughter, demonstrating tha significant number of animals never diagnosedwith BRD do, in fact, suffer from some degree ofrespiratory disease11

The BRD Complex


3/4

Titanium 5 + PH-M the convenience and flexibility of a singlevaccine that protects against BRD-causing viruses and bacteria

Protects against the two bacteria most associated with BRD:1

Mannheimia haemolytica the bacterium most frequently isolated from lungsof cattle with BRD

Pasteurella multocida an important cause of bacterial pneumonia

Also protects against five important virus strains:2,3

BVD, types 1 and 2 PI3 IBR BRSV

Approved for use in cattle 2 months of age and older, Titanium 5 + PH-M is flexibleenough to be incorporated into virtually any vaccine protocol. Producers should workwith their veterinarian to determine the best way to incorporate Titanium 5 + PH-M. As ageneral guide, it fits well in branding and/or preconditioning vaccine protocols, as well asin arrival programs for stocker and feedyard operations.

Helping your cattle overcome the one-two punch of

viruses and bacteria requires a vaccine solution

that provides a broad immune response against the

bacteria and viruses most associated with BRD.

Do you haveviruses &bacteriacovered?

Titanium 5 + PH-

Protects against therespiratory viruses anbacteria most associawith BRD

Offers the convenienca single vaccine at evstage of production

Contains a research-proven M. haemolytic

leukotoxoid and otheantigens to stimulatean immune responseBRD-causing virusesand bacteria

Includes a low-reactivwater-soluble adjuvanand is proven safe focattle as young as2 months of age

Its low-volume,subcutaneousadministration meetsBeef Quality Assuranc(BQA) guidelines


4/4

Titanium 5 + PH-M proven effective andsafe at every stage of production

valuated under U.S. Department of Agriculture requirements,itanium 5 + PH-M was proven safe and effective for cattle at alltages of production, with no interference between the viral andacterial components of the vaccine. Research comparingaccinated calves to controls after infection with M. haemolytica

howed Titanium 5 + PH-M:

1

Reduced lung lesions* by 82 percent (P< 0.01) Reduced clinical signs of infection significantly (P< 0.01)

Mitigated fraction: the effect of a vaccine in reducing severity of disease.

tudies also showed Titanium 5 + PH-M: Provided the same viral protection (BVD, types 1 and 2, IBR,

PI3, BRSV) as Titanium 52,3

Protected against severe clinical signs of BRD1-3 Resulted in no adverse events beyond minimal injection-site

swelling4

100%

80%

60%

40%

20%

0%

Day 1 Day 2 Day 3 Day 4

Figure 1. M. Haemolytica Challenge Study Survival Rate1

Su

rvivalRate

Group 1: PH-M

Group 2: Titanium 5 + PH-M

Control

Elanco, Titaniumand the diagonal bar are trademarks owned or

licensed by Eli Lilly and Company, its subsidiaries or affiliates. 2014 Elanco Animal Health.VAC 31892-2

The label contains complete use information, includingcautions and warnings. Always read, understand and follo

the label and use directions. Do not vaccinate within 21 dof slaughter.

1Milliken, G. A. 2013. Mannheimia haemolytica efficacy studies demonstrating the absof excessive interference of Titanium products with the Mannheimia haemolytica-Pasmultocida bacterin-toxoid.

2Demonstration of the compatibility of components between APHIS product codes 11(Establishment 213) and G935.04 (Establishment 315) APHIS product code 45B9.20No. 2010-01 Rev. 1.

3Efficacy study for BRSV fraction to demonstrate compatibility of the BRSV componenAPHIS product code: 45B9.20 (unlicensed). Study No. 2011-05 Rev. 1.

4Porter, M. 2011. Field safety evaluation of bovine rhinotracheitis-virus diarrhea-parainfluenza3-respiratory syncytial virus vaccine, modified live virus, APHIS product1181.20 (establishment 213) in combination with Mannheimia haemolytica-Pasteuremultocida bacterin-toxoid, APHIS product code: G935.04 (establishment 315). Proto2011-01, Rev. 02.

5Edwards, A. J. 1996. Respiratory Diseases of Feedlot Cattle in the Central USA. BovinPractitioner. 30:5-7.

6Galyean, M. L., L. J. Perino and G. C. Duff. 1999. Interaction of Cattle Health/Immuni

Nutrition. J. Anim. Sci. 77:1120-1134.7Loneragan, G. H., D. A. Dargatz, P. S. Morley, and M. A. Smith. 2001. Trends in MortRatios Among Cattle in US Feedlots. J. Am. Vet. Med. Assoc. 219:1122-1127.

8Chirase, N. K. and L. W. Greene. 2001. Dietary zinc and manganese sources administfrom the fetal stage onwards affect immune response of transit stressed and virus infoffspring steer calves. Animal Feed Science and Technology. 93:217-228.

9Smith, R. A. 1998. Impact of Disease on Feedlot Performance: A Review. J. Anim. Sc76:272274.

10Bateman K. G., S. W. Martin, P. E. Shewen and P. I. Menzies. 1990. An evaluation ofantimicrobial therapy for undifferentiated bovine respiratory disease. Can. Vet. J. 31:6

11Wittum T. E., N. E. Woollen, L. J. Perino and E. T. Littledike. 1996. Relationships amtreatment for respiratory tract disease, pulmonary lesions evident at slaughter, and raweight gain in feedlot cattle. J. Am. Vet. Med. Assoc. Aug 15;209(4):814-8.

USBBUTIT0

Elanco.us

Learn more aboutTitanium 5 +PH-M

the new single-vaccine solutionthats approved for cattle asyoung as 2 months of age.

The Titaniumline of vaccines is a brandyouve come to trust the brand thatbrought you the first type 2 BVDmodified-live virus (MLV) vaccine.

Figure 2. Titanium 5 + PH-M Safety Study Injection-Site Evaluation4

Calves vaccinated on Day 1 and revaccinated on Day 21.

Percentofanimals

Day 4-6 Day 21 Day 25-27 Day 42

100%

80%

60%

40%

20%

0%

Injection-site swelling measurements

0 5 cm1.5 - 5 cm

do you have bacteria and viruses covered

Documents