do you think this is just a normal pig? you are wrong!
TRANSCRIPT
Do you think this is just a normal pig?
You are wrong!
This pig is responsible for
This pig is responsible for
Haemagglutinin 1
This pig is responsible for
Haemagglutinin 1
Haemagglutinin 2
This pig is responsible for
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
AND
This pig is responsible for
Neuraminidase 1
This pig is responsible for
Neuraminidase 1
Neuraminidase 2
IT’S NOT JUST A NORMAL PIG IS IT?
The pig is one of the key contributors to Influenza A virus.
THESE ANIMALS ARE RESPONSIBLE AS WELL
The Horse
The Horse
Haemagglutinin 3
The Horse
Haemagglutinin 3
Haemagglutinin 7
AND
Birds are responsible
For……..
Birds
Haemagglutinin 1
Birds
Haemagglutinin 1
Haemagglutinin 2
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Haemagglutinin 6
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Haemagglutinin 6
Haemagglutinin 7
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Haemagglutinin 6
Haemagglutinin 7
Haemagglutinin 8
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Haemagglutinin 6
Haemagglutinin 7
Haemagglutinin 8
Haemagglutinin 9
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Haemagglutinin 6
Haemagglutinin 7
Haemagglutinin 8
Haemagglutinin 9
Haemagglutinin 10
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Haemagglutinin 6
Haemagglutinin 7
Haemagglutinin 8
Haemagglutinin 9
Haemagglutinin 10
Haemagglutinin 11
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Haemagglutinin 6
Haemagglutinin 7
Haemagglutinin 8
Haemagglutinin 9
Haemagglutinin 10
Haemagglutinin 11
Haemagglutinin 12
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Haemagglutinin 6
Haemagglutinin 7
Haemagglutinin 8
Haemagglutinin 9
Haemagglutinin 10
Haemagglutinin 11
Haemagglutinin 12
Haemagglutinin 13
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Haemagglutinin 6
Haemagglutinin 7
Haemagglutinin 8
Haemagglutinin 9
Haemagglutinin 10
Haemagglutinin 11
Haemagglutinin 12
Haemagglutinin 13
Haemagglutinin 14
Birds
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 4
Haemagglutinin 5
Haemagglutinin 6
Haemagglutinin 7
Haemagglutinin 8
Haemagglutinin 9
Haemagglutinin 10
Haemagglutinin 11
Haemagglutinin 12
Haemagglutinin 13
Haemagglutinin 14
Haemagglutinin 15
As well as…
Birds
Neuraminidase 1
Birds
Neuraminidase 1
Neuraminidase 2
Birds
Neuraminidase 1
Neuraminidase 2
Neuraminidase 3
Birds
Neuraminidase 1
Neuraminidase 2
Neuraminidase 3
Neuraminidase 4
Birds
Neuraminidase 1
Neuraminidase 2
Neuraminidase 3
Neuraminidase 4
Neuraminidase 5
Birds
Neuraminidase 1
Neuraminidase 2
Neuraminidase 3
Neuraminidase 4
Neuraminidase 5
Neuraminidase 6
Birds
Neuraminidase 1
Neuraminidase 2
Neuraminidase 3
Neuraminidase 4
Neuraminidase 5
Neuraminidase 6
Neuraminidase 7
So the bird is the host to most of Influenza A virus
Humans are also a key factor to the virus by being the predominant host to…………
Haemagglutinin 1
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 5
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3Haemagglutinin 5
Haemagglutinin 7
Haemagglutinin 1
Haemagglutinin 2
Haemagglutinin 3
Haemagglutinin 5
Haemagglutinin 7
Haemagglutinin 9
And………
Neuraminidase 1
Neuraminidase 1
Neuraminidase 2
• Haemagglutinin and Neuraminidase are glycoprotein's of the virus.
• The virus subtypes depends on the nature of these glycoproteins on the virus’ surface.
• There are 15 different types of Haemagglutinin and 9 different types of Neuraminidase.
Now we are going to tell you the story of ….
Deadly disease strikes farm
This is Devin the pig.
I live here in my mud puddle, here at
Millsberry farm.
This is Chirpy the bird.
I live in this tree just opposite Millsberry farm.
This is Jeffery the horse
I live in my luscious green paddock at Millsberry farm.
This is Bill the farmer
I live in my little English style cottage
on Millsberry farm
Awwww I feel so sick.
I’m not feeling very well either. I think I’ve got influenza.
It seems like you have the Influenza C. But don’t panic, it is not
anything serious. Just stay in bed for a few
days and you should feel better.
Even though I’m still sick, I need to feed
the animals.
Maybe if I go for a fly over the farm I might feel better.
I feel so much better today.
I know longer feel sick. I must be
back to normal.
But on the other hand Devin was feeling awful. He had caught the virus. Jeffery was okay because he was naturally immune to the virus.
I feel really sick. I have
caught Chirpy’s virus and
Farmer Bill’s virus.
Farmer Bill cared for Devin all night long.
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I feel so
sick…..
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Click in random order!
The term Influenza, was derived from the Italian word ‘influentia’
in mid 1300s
It was believed that you caught the disease from astrological influences.
It is 1718 and an Influenza
pandemic has occurred
It is very bad as you can see..
It has been called the Spanish Flu
and H1N1 is responsible.
We have been trying to do absolutely
everything, but it is very difficult.
The reason why I’m not sick is because I
have immunity to the disease, so I
won’t catch it for a long time.
24 million people have died already in
the Western.
Spanish Flu and Bubonic Plague
have decreased the world’s population
the most.
Hopefully, isolating these people will over come this terrible event.
Click in random order!
From that pandemic, others have occurred as well due to Influenza A virus.
In 1957, it was the Asian flu or H2N2…..Then in 1968 the influenza pandemic aka The Hong Kong flu or H3N2 occurred.
In 1975, the H1N1 disease started to circulate again, but was not as deadly as the first time but did not kill old people as they had immunity to it.
Since then, doctors and scientist have been researching for many years.
From our research, we are able to tell
you….
Influenza is a very powerful disease. The
disease is spread simply by coming in
contact with someone with the disease.
Your immune system causes you to feel sick. Without the
immune system you will die of the disease. The virus is very, very small. It is not a living
being.
The influenza disease that is most worried about at the moment
is H5N1, aka the avian flu.
80% of the people whom have been infected with the avian flu have died. The flu works differently in different people.
The glycoprotein's of the virus are Haemagglutinin (HA) and Neuraminidase (NA). HA is responsible for infectious entry of virus into cells. HA is rod shaped. NA is mushroom shape.
Influenza A is responsible for all pandemic and epidemic
outbreaks.
Influenza B can also also causes human disease of influenza. Influenza C has little clinical
importance. There are quite a lot of different types of influenza. There are approximately 20
different categories of influenza.
Each year (for an example) the H1N1 disease will change by little bits which are known as drifts. But when the H1N1 disease changes completely to something like H2N2, it is
called a shift.
How the disease mutates each year
Human flu
Avian flu
How the disease mutates each year
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People at high riskPregnant people
Children under 2 yearsAdults 65 years and older
People with chronic disease and
Immunocompromised people
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So we have a sustainable futureWe have to recognise that influenza viruses are responsible for seasonal
epidemics/pandemicsWe are 10 years overdue for our next
pandemicBut it can come at anytime due to our
low immunity
If you have….
Fever (>37.8 degrees) and/or feverish
PLUSTwo of
Cough, sore throat, nasal symptoms, Myalgia, headache or Malaise
GO TO THE DOCTOR A.S.A.Pwho could prescribe you…
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now!
Relenza
Designed to plug the hole in Neuraminidase which would stop the virus
Puffer which delivers straight to the lungs
$50 each and hard to manufacture
Stops spread but doesn’t cure it
Have it once a week
It would take two weeks for you immune to response
Or Tammy flu/vaccinationTammy flu is like
Relenza, just in tablet form
The vaccine may look big and painful, but it is
better than ending up…….
Hmmm…. I wish I got that vaccination. I surely
paid for it! Get yours when you can get it!
So lets have a sustainable future by following the
previous steps……because Influenza A virus as well as
the other types can be
DEADLY
Click both
sounds now!
Thankyou• Professor Robin Anders
• Dr Andy Coley
Without the interviews with these generous academics, it would have been difficult to understand our topic.
Bibliography• Book - Influenza
Wilschut and McElhaney
• Wikipedia
Hope you enjoyed the movie!
Project
By
Courtney Remington
Simone Karafilis
Joel Galea
Max Rowlands
Ollie Xue
Tom
YR 9 – IVANHOE GRAMMAR SCHOOL, LA TROBE