doenÇa de newcastle. newcastle disease family paramyxoviridae –genus avulavirus 9 serotypes...
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DOENÇA DE NEWCASTLE
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Newcastle Disease
• Family Paramyxoviridae– Genus Avulavirus
• 9 serotypes APMV-1 to APMV-9
• Newcastle disease is APMV-1
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Influenza Aviar Enfermedad de Newcastle
Patógeno respiratorio inicial inicial
Acido nucleico RNA RNA
Simetría helicoidal Helicoidal
Envoltura lipídica lipídica
Receptor celular ácido sialico ácido sialico
Antigenicamente estable estable
Semelhanças entre Newcastle e influenza
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Influenza Aviar Enfermedad de Newcastle
Organización del genoma segmentado No segmentado
Localización de la síntesis del RNA Núcleo Citoplasma
Inhibición con Actinomicina D Sensible Resistente
Reasociación o recombinación genética Alta No detectada
Sitio de fusión Endosomal Membrana plasmática
Diferenças entre newcastle e influenza
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Newcastle Disease• Quatro patotipos:
– Sub- clínico entérico assintomático
– Lentogênico• Subclinico e
leve/respiratório
– Mesogênico• Respiratório ou neurológico
– Velogênico• Neurotrópico: Respiratório
ou neurológico• Viscerotrópico: lesões
intestinais hemorrágicas
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Atualmente se prefere a classificação por:
• Índice de patogenicidade intra-cerebral• Índice de patogenicidade intra-venosa
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PATOGENIA
• Replicação no trato respiratório - nervoso
• Replicação no trato digestivo
• Difusão rápida• Período de incubação
variável ( 5 a 6 dias) mas até 15 dias eventualmente
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Históricos
• 2002-2003: California
– 4 milhões de aves destruidas
– $160 milhões de dólares de prejuízo
• Julho e agosto de 2006 - Brasil
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Morbidade/Mortalidade• Morbidade: até 100%• Mortalidade: 90%• Variação depende
principalmente de:– Virulência e cepa viral– Espécie aviária e
susceptibilidade do hospedeiro– Condições ambientais– Infecções secundárias/
desencadeantes– Histórico de vacinação
• Algumas espécies mostram pouco ou nenhum sinal– Pode existir o estado de
portador
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Transmissão animal
• Contato direto com fezes ou descargas respiratórias
• Contaminação do ambiente– comida, água– Equipamentos– Vestimentas humanas– Vacinas contaminadas
ou mal inativadas
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Transmissão animal
• Sobrevive por “longo” período no ambiente
• Período de incubação: 2-15 dias– 5-6 dias em média
• Aves migratórias ou sinantrópicas
Cama de frango contaminada
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Transmissão humana• Conjuntivite leve
– Virus nas secreções oculares por 4-7 dias
– Contato íntimo com espécies aviárias durante este tempo
• Trabalhadores de laboratório e vacinadores
• Improvável por manipulação ou consumo de frango
• Sem disseminação humano-humano
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Sinais clínicos
• Queda da produção de ovos
Excesso de mortalidade dentro de 24-48 horas
• Mortes continuam por 7-10 dias
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Sinais clínicos
• Edema do olho, especialmente ao redor dos olhos
• Diarréia aquosa esverdeada ou negra
• Sinais respiratórios e/ou neurológicos
• Sinais variam com a espécie e virulência
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Ações recomendadas
• Diagnóstico confirmatório
• Despopulação talvez– Na propriedade
destruição de:• Cadaveres• fômites• Produtos animais
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POSSIBILIDADES EM NOSSA REALIDADE
• Crematório• Compostagem• Enterrar• Queimar
• ???
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Desinfecção
• Vírus morre por:
– Extremos de pH• Menor que 2 ou maior
que 12
– calor• Fervura por 1 min.
– Detergentes– Baixa umidade– Luz do sol e
ultravioleta
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Prevenção
• Vacinação• biosseguridade
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Quando vacinar??
• Que tipo e recomendação o país deve determinar e qual a autonomia dos produtores na avaliação da necessidade do uso desta ferramenta.
• A Implementação da DIVA e a regionalização devem ser estratégias viáveis a médio prazo.
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Reconhecimento precoce das enfermidades
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Outros pontos a se considerar
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Não visite seu vizinho se você tem um problema!
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Programas de biosseguridade exigem flexibilidade
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Fique atento aos sinais de problema( perigo)
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Se antecipe ao inesperado