Supporting Information

Mesoporous Manganese Silicate Coated Silica Nanoparticles as Multi-Stimuli-Responsive T1-MRI Contrast Agents and Drug Delivery Carriers

Xiaowei Li, Wenru Zhao*, Xiaohang Liu, Kaiqiang Chen, Shaojia Zhu, Ping Shi, Yu Chen, Jianlin Shi*

Supplementary figures

Fig. S1. N2 adsorption/desorption isotherms and pore size distribution (inset) of MMSSNs.

Fig. S2. XRD patterns of SiO2 (black line) and MMSSNs (red line).

1

Fig. S3. Mn 2p XPS of MMSSNs.

Fig. S4. UV spectra of a) FITC, b) MMSSNs and c) FITC-labeled MMSSNs.

Fig. S5. UV spectra of DOX solution a) before and b) after incubation with MMSSNs.

2

Fig. S6. Zeta potential of MMSSNs, DOX-loaded MMSSNs and the MMSSNs after DOX released.

Fig. S7. a) N2 adsorption/desorption isotherms and b) pore size distribution of MMSSNs and DOX-loaded MMSSNs.

Fig. S8. CLSM images of MCF-7 cancer cells after 2 h incubation with DOX-loaded MMSSNs ([DOX] = 10 µg mL−1). a) the nuclei stained by DAPI, b) DOX, c) merged image.

3

Fig. S9. Effect of MMSSNs on the viability of PC-12 cells for 24 h, measured by MTT assay.

Fig. S10. Effect of MMSSNs on the viability of PC-12 cells for 48 h, measured by MTT assay.

Fig. S11. The Mn degradation percentages of MMSSNs at different concentrations: 0.1 mg mL−1 (MMSSNs-1); 0.3 mg mL−1 (MMSSNs-2) and 0.5 mg mL−1 (MMSSNs-3).

4

Fig. S12. The Si degradation percentages of MMSSNs at 0.1 mg mL−1.

5