Inpharma 1390 - 7 Jun 2003

■ Donor T cells have graft-versus-tumour activity inpatients with metastatic breast cancer, according toresults from a phase I study presented at the AnnualMeeting of the American Society of Clinical Oncologyheld recently in Chicago, US. Thirteen patients withmetastatic breast cancer received conventionalchemotherapy followed by stem cell transplants fromHLA*-matched siblings. T cells were removed from thedonor pools before transplantation. At 42 days post-transplantation, the T cells were administered in 3infusions over 2 months. T-cell administration shrunktumours by ≥ 50% in four of the patients. Minorresponses were observed in a further three patients.* human lymphocyte antigen

National Cancer Institute. Donor immune cells attack metastatic breast cancer.Media Release : 2 Jun 2003. Available from: URL: http://www.nci.nih.gov 809021586

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Inpharma 7 Jun 2003 No. 13901173-8324/10/1390-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved