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  • 7/31/2019 Dose Levels

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    Expectedhealtheffectsforanadultassumingthecumulativetotalradiationexposurewasallreceivedwithinawee stime.Forchildren,theeffectscanbeexpectedathalfthesedoselevels.

    TOTALEXPOSURE ONSET&DURATIONOFINITIALSYMPTOMS&DISPOSITION

    30to70R From6-12hours:nonetoslightincidenceoftransientheadacheandnausea;

    vomitinginupto5percentofpersonnelinupperpartofdoserange.Mild

    lymphocytedepressionwithin24hours.Fullrecoveryexpected.(Fetusdamage

    possiblefrom50Randabove.)

    70to150R From2-20hours:transientmildnauseaandvomitingin5to30percentof

    personnel.Potentialfordelayedtraumaticandsurgicalwoundhealing,

    minimalclinicaleffect.Moderatedropinlymphocycte,platelet,and

    granulocytecounts.Increasedsusceptibilitytoopportunisticpathogens.

    Fullrecoveryexpected.

    150to300R From2hourstothreedays:transienttomoderatenauseaandvomitingin

    20to70percent;mildtomoderatefatigabilityandwea nessin25to60

    percentofpersonnel.At3to5wee s:medicalcarerequiredfor10to50%.

    Athighendofrange,deathmayoccurtomaximum10%.Anticipatedmedical

    problemsincludeinfection,bleeding,andfever.Woundingorburnswill

    geometricallyincreasemorbidityandmortality.

    300to530R From2hourstothreedays:transienttomoderatenauseaandvomitingin50

    to90percent;mildtomoderatefatigabilityin50to90percentofpersonnel.

    At2to5wee s:medicalcarerequiredfor10to80%.Atlowendofrange,

    lessthan10%deaths;athighend,deathmayoccurformorethan50%.

    Anticipatedmedicalproblemsincludefrequentdiarrhealstools,anorexia,

    increasedfluidloss,ulceration.Increasedinfectionsusceptibilityduring

    immunocompromisedtime-frame.Moderatetoseverelossoflymphocytes.

    Hairlossafter14days.

    530to830R From2hourstotwodays:moderatetoseverenauseaandvomitingin80to

    100percentofpersonnel;From2hourstosixwee s:moderatetosevere

    fatigabilityandwea nessin90to100percentofpersonnel.At10daysto

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    5wee s:medicalcarerequiredfor50to100%.Atlowendofrange,death

    mayoccurformorethan50%atsixwee s.Athighend,deathmayoccur

    for99%ofpersonnel.Anticipatedmedicalproblemsincludedeveloping

    pathogenicandopportunisticinfections,bleeding,fever,lossofappetite,

    GIulcerations,bloodydiarrhea,severefluidandelectrolyteshifts,capillary

    lea ,hypotension.Combinedwithanysignificantphysicaltrauma,survival

    rateswillapproachzero.

    830RPlus From30minutesto2days:severenausea,vomiting,fatigability,wea ness,

    dizziness,anddisorientation;moderatetoseverefluidimbalanceandheadache.

    Bonemarrowtotaldepletionwithindays.CNSsymptomsarepredominantat

    higherradiationlevels.Few,ifany,survivorsevenwithaggressiveand

    immediatemedicalattention.