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A Neuroendocrine Model for Healthy Aging
Speaker: Sharon Norling, MD, MBADecember 13, 2013
Booth - 3046
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Surgery Medicine
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Prevalence of Mood Disorders
26.2% 18 and older – about 1 in 4 adults.
57.7 million people
45% meet criteria for 2 or more disorders
Comorbidity
1. Kessler RC, Archives of General Psychiatry, 62(6) (January 2005): 617-27.2. U.S. Census Bureau Population Estimates by Demographic Characteristics.
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CLIA High Complexity Clinical Testing Laboratory
CLIA: 34D1054007
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NeuroLab™
Laboratory results include integrative clinical commentary personalized to the patient health data and current laboratory values.
Personalized medicine
Treating the average is OVERATED!
Neuroendocrine systems analysis of chronic and acute conditions from depression to metabolic syndrome
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Inhibitory Neurotransmitters
Serotonin
GABA
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Excitatory Neurotransmitters
Dopamine
Nor-epinephrine
Epinephrine
Glutamate
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Adrenal Hormones
DHEA-s – (2-point)
Cortisol – (4-point)
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Neurotransmitters
Anxious?
Depressed?
Mood swings?
Difficulty sleeping?
Experiencing pain?
Lacking motivation?
Low libido?
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Pharmaceutical Drugs
Mood-altering drugs are considered affective if it reduces depression 50%
SSRI’s help 30-50 % of the time but have side effects 86% of the time
Turner looked at 74 clinical trials and found the drug worked 51% and the placebo 49%
Erick H Turner MD, et al. “Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy,” NEJM (January 17, 2008); 358: 252-60.
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Evolution of Model Mood Disorders
Middle Ages: Demons within-exorcism is therapy of choice
1917: Freud explains that those demons are really our mothers
1988: Eli Lilly releases our mothers from 80 years of victimization, explaining that depression is really a Prozac deficiency
Dr. Hedaya, Clinical Professor of Psychiatry Georgetown University.
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Disease Management & the Organization of Physician Practice
“There is a large gap between what physicians do for
patients with chronic diseases and what should be done.”
Disease Management and the Organization of Physician PracticeLawrence P. Casalino, MD, PhDJAMA. 2005;293(4):485-488.
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Causes of Neurotransmitter
Imbalance
Life Gluten Lack of nutrition and
blood sugar Hormone imbalance
Low thyroid Adrenal fatigue Toxins Infections Lack of sleep
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LIFE
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Causes of Neurotransmitter
Imbalance
Life
Gluten Lack of nutrition and
blood sugar Hormone imbalance
Low thyroid Adrenal fatigue Toxins Infections Lack of sleep
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Gluten Sensitivity
Depression in 52%
Injured GI lining decreases the effectiveness of absorbing essential nutrients to keep the brain healthy.
Zinc, tryptophan, and B Vitamins
“second brain” produces 80-90 percent of serotonin
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Causes of Neurotransmitter
Imbalance
Life Gluten Lack of nutrition
and blood sugar Hormone imbalance
Low thyroid Adrenal fatigue Toxins Infections Lack of sleep
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Vitamin D
Low levels contribute to depression and chronic fatigue
Adequate Vitamin D needed by the adrenal gland for the production of dopamine, epinephrine, and norepinephrine
Several months of supplementation
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High Blood Sugar
“when your blood sugar rises there is an immediate depletion of the
neurotransmitters serotonin, epinephrine, norepinephrine, GABA, and dopamine. B-complex, which is needed to make neurotransmitters, gets used
up.”
David Perlmutter, MD, Grain Brain (New York, Boston, London: Little, Brown and Company, 2013).
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REAL EASY
REAL LIFE
REAL IMPORTANT
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High Blood Sugar
“ The most powerful tool you have to change your body and your health is
your fork.”
Mark Hyman, MD
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Causes of Neurotransmitter
Imbalance
Life Gluten Lack of nutrition and
blood sugar
Hormone imbalance
Low thyroid Adrenal fatigue Toxins Infections Lack of sleep
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Hormone Imbalance: Statins
“If you deprive the brain of cholesterol, then you directly affect the machinery that
triggers the release of neurotransmitters.
Cholesterol changes the shape of the proteins to stimulate thinking and memory.”
David Perlmutter, MD, Grain Brain (New York, Boston, London: Little, Brown and Company, 2013).
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Hormones & Neurotransmitters
Strong interaction E2 and serotonin
Progesterone and GABA
Testosterone and DHEA
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Causes of Neurotransmitter
Imbalance
Life Gluten Lack of nutrition and
blood sugar Hormone imbalance
Low thyroid Adrenal fatigue Toxins Infections Lack of sleep
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Symptoms of Low Thyroid Production
Depression
Anxiety
Decreased memory
Inability to concentrate
Migraine headaches
Muscle and joint pain
Menopausal symptoms and PMS
Insomnia
Fatigue
Low libido
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Causes of Neurotransmitter
Imbalance
Life Gluten Lack of nutrition and
blood sugar Hormone imbalance
Low thyroid
Adrenal fatigue
Toxins Infections Lack of sleep
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Adrenal Hormones
DHEA-s
Cortisol
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Dancing Hormones
AdrenalineGABA
CortisolThyroid
InsulinSerotonin
Estrogen Glutamate
Progesterone DHEA
DopamineTestosterone
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NeuroLab™
Leading specialist in the technology, analysis, and research of the biomarkers relating to HPA-T axis function.
Leaders in the clinical application of urinary HPLC/MS testing.
Certified by CLIA as High Complexity Clinical Laboratory
Participates in College of American Pathology & BIORAD proficiency testing for salivary samples.
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Amino acids
“We have found that if a drug can be found to do the job of medical healing, a nutrient can be found
to do the same job. We now know that if we give the amino acids the body will synthesize
neurotransmitters, thereby achieving the same effect as drugs.
The challenge of the future is to replace drugs with these natural healers.”
Dr. Carl Pfeiffer, a pioneer amino-acid researcher.
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Step 1: Assessment
• Assess the patients’ neurotransmitter and adrenal hormone biomarkers with a non-invasive laboratory test
• Establishes a baseline on first test, looking for imbalances affecting HPA-T axis function.
• Important tool for monitoring and adjusting therapy to meet the patient’s individual biochemical needs
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Step 2: Correlation
• Personalized laboratory results to patient specific symptoms and, current treatments, and lifestyle factors
• Comprehensive review of patient’s neuroendocrine system
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Step 3: Correction
Sanesco’s exclusive line of TNT products are natural, non-drug formulas balanced with specific low dose amino acid precursors and nutrient cofactors designed to support neurotransmitter and hormone pathways showing imbalances affecting HPA-T axis function.
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Targeted Nutritional Therapy- safe & clinically effective
Prolent™ (inhibitory support)
Lentra™ (GABA receptor support)
Procite-D™ (dopamine support)
Contegra™ (catecholamine formula)
MethyMax™ (methylation support)
Adaptacin™ (adrenal support)
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Effective Clinical Tool
1. Symptomatic patient does a test
2. Test reveals a number
3. Intervention is made
4. Test is repeated
5. Number improves
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Neurotransmitters
Gluten Sensitivity
Hormones
•Anxiety•Depression•Insomnia•Fatigue•Joint Pain•Memory Loss•Poor Concentration•Low Libido•Carb Cravings•Muscle stiffness
•Anxiety•Depression•Insomnia•Fatigue•Joint Pain•Memory Loss•Poor Concentration•Low Libido•Carb Cravings•Muscle stiffness
•Anxiety•Depression•Insomnia•Fatigue•Joint Pain•Memory Loss•Poor Concentration•Low Libido•Carb Cravings•Muscle stiffness
Neurotransmitters
Hormones
•Anxiety•Depression•Insomnia•Fatigue•Joint Pain
•Memory Loss•Poor Concentration•Low Libido•Carb Cravings•Muscle stiffness
Gluten Sensitivity
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Summary
Assess patients for mood disorders
Remove known causes of imbalances
Test using NeuroLab, leading specialty laboratory in the technology, analysis, and research of HPA-T axis function
Balance neurotransmitters with Sanesco’s specific amino acid targeted nutrient therapy for safe effective clinical results
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Neurotransmitters
Anxious?
Depressed?
Mood swings?
Difficulty sleeping?
Experiencing pain?
Lacking motivation?
Low libido?
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Question
Is thereSEX
before or after menopause ?
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Sexual Frequency Across the Life Cycle
Age Frequency
30-40 Tri - weekly
40-50 Try weekly
50-60 Try weakly
60-70 Try
70-80 Try something else
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Remember
Laughter is the BEST Medicine
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A Neuroendocrine Model for Healthy Aging
Dr. Sharon Norling5655 Lindero Canyon Rd
Westlake Village, CA
Your Doctor is Wrongwww.drsharonnorling.com
Come by booth 3046 for an opportunity to meet Sharon Norling MD, MBA and receive a signed copy
of the her book.
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Continue the Conversation with Us
Booth - 3046