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IV MOTILITY OF THE SMALL INTESTINE
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Function of Intestinal Motility
(1)To mix chyme with digestive secretion
(2)To bring fresh chyme into contact with the absorptive surface of the microvili
(3)To propel chyme toward the colon
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1. Tonic contraction: the base of the other contractions
2. Segmentation contractions
(1) def.
When a portion of the small intestine becomes distended with chyme,
the stretch of the intestinal wall elicits a rhythmical contraction and relaxation of localized circular muscles
spaced at intervals along the intestine,
(2) function:
mix the chyme with the digestive juice
increase its exposure to the mucosal surface
Types of small intestinal movement
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3. Peristalsis: propels the small intestinal contents towards the large intestines
peristaltic rush : initiated by the harmful stimulation
4. MMC:
Occurs during fasting state
moves any undigested material still remaining in the small intestine into the large intestine
prevents bacteria from remaining in the small intestine long enough to grow and multiply excessively
Types of small intestinal movement
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Segmentation: mix contents to promote digestion & absorption
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Peristalsis• Distinctive pattern of smooth muscle contractions that prop
els foodstuffs distally through the esophagus and intestines
• Mediated by….
• Local, intrinsic nervous system
• Ex: peristalsis is not affect to any significant degree by v
agotomy or sympathectomy
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Small Intestinal Motility Peristalsis: movement along the tract
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Peristalsis
Figure 24.4
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peristalsis
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Peristalsis of the small intestine
http://medweb.bham.ac.uk/research/toescu/Teaching/OverviewGITY2.html
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11Berne et al., 2004
Peristalsis – law of intestine
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12Berne et al., 2004
Peristalsis – law of intestine
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13Berne et al., 2004
Peristalsis – law of intestine
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14Berne et al., 2004
Peristalsis – law of intestine
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Peristalsis – law of intestine
Berne et al., 2004
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Peristalsis – law of intestine
• Bolus of food →Mechanical distension and mucosal irritation → stimulates afferent enteric neurons → 2 effects
1.Excitatory motor neurons above the bolus activated → contraction of smooth muscle above the bolus
• Via Ach, substance P
2. Inhibitory motor neurons → stimulate relaxation of smooth muscle below the bolus• Via nitric oxide, vasoactive intestinal peptide and AT
P
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Control of Intestinal Motility – Neuronal
Mixing – segmentation
Frequency set by slow waves (12/minute duodunum)
additional control: myenteric plexus
Propulsion – peristalsis
Local reflex – stretch causes relaxation distal and contraction proximal (Bayliss – Starling law of the intestines)
Moves bolus through intestines
Intestino-intestinal reflex – extrinsic nerves
Local stretch in one area inhibits contraction in rest of bowel
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Movement in Small IntestinePeristalsis (ou propulsivos) e Segmentation (mixing)
http://medweb.bham.ac.uk/research/toescu/Teaching/OverviewGITY2.html
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Luminal stimuli elicit vago-vagal reflexes which activate integrating and program circuits of the enteric nervous system. These activate specific motorneurones responsible for specific contractile patterns.
Central and peripheral control of contractile patterns
Intestinalwall
Vagalcentre
Intestinallumenl
Peptide (CCK) ReceptorsGlucose - OsmolalityLong chain fatty acidsAmino acids
Sensory neurons
Vago-vagal reflexes
InterneuronsIntegrating circuits
Program circuits
Enteric nervous system
Motorneurons Contractilepatterns
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Gastrin Secretin
CCK + motility -- Glucagon
5-HT VIP
Motilin GIP
Control of Intestinal Motility – Hormonal
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Ileocecal Valve
• What it is• Opening to large intestines
• Function: (1) prevent the repulsion (2) control the emptying• normally closed. Short-range peristalsis in terminal ileum an
d distension relaxes IC sphincter --> small amount of chyme is squirted into the cecum.
• Distension of cecum contracts IC sphincter.• Gastro-ileal reflex: enhances ileal emptying after eating. • The hormone gastrin relaxes ileocecal sphincter.
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V. GASTROINTESTINAL MOTILITY DURING FASTING STATE
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Gastric motility on fasting“Migrating Motor Complex, MMC”
Occurs during fasting
To clear undigested food particles
Peristaltic contractions sweep down stomach and
duodenum – pylorus relaxes
Pattern of contraction approx every 90 min
Slow peristaltic waves sweeping whole of GI tract
Thought to be controlled by motilin ( 胃动素)
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MMC(migrating motor complex)
• Phase : Almost have no contractions 40-60 minⅠ• Phase : have contractions, only have few 30-45 minⅡ• Phase : have continuous contractions 5-10 minⅢ
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The phase III of the migrating motor complex (of dog)
Originates simultaneously at the stomach and duodenum
Migrates within 90 to 120 minutes along the small intestine
Interdigestive CyclesPhases
Sporadicperistaltic waves
Segmenting contractionsand single
peristaltic waves
Motorquiescence of stomach
and duodenum
Contractionof reservoir
Pylorus
Aboral migration
Accumulation of residues
of chyme
Phase IIPhase I
Stomach
Duodenum
Jejunum
Ileum
Phase III
Phase III
III I II III
Phase III
Phase II
Phase I
Forcefulperistaltic
waves
Motorquiescence
The interdigestive motility consists of three phases
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Importance of MMC
1.Sweep the contents of the small intestine
towards the colon
Housekeeper of the small intestine
2.Inhibit the migration of colonic bacteria into
the terminal ileum
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VI MOTILITY OF THE COLON
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Large intestine
• Functions• Absorption of water and electrolytes• Storage of feces• In non-ruminant herbivores, fermentative digestion
and absorption of nutrients
• Motility patterns• mixing (form haustrations)• propulsive (mass movements)
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Segmentation in large intestine
• Haustration: (结肠袋)modified form of segmentation in which intense, local contraction of circular muscle causes large intestine to appear to bulge into sacs
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Mass movement
• Occurs in colon; also known to occur in equine cecum
• Period of intense propulsive activity that moves entire contents of colon distally toward rectum• Contractions progress for long distance such that long len
gth of colon contracts as a unit
• Entry of fecal matter into recturn triggers defecation reflex
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Mass Movement
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Defecation
Defecation Reflexinitiated when rectal walls stretch
parasympathetic reflex
walls of the sigmoid colon and the rectum to contract & relaxation of
the anal sphincter
External sphincter control is voluntary control
If defecation is delayed: the reflex
stops until the next mass movement