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KYPHON® Balloon Kyphoplasty
Minimally Invasive Treatment of Tumor-Related Vertebral Compression Fractures
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Regulation of Bone Metabolism
1. Roodman GD, NEJM, 350;16,2004
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Metastatic Bone DiseaseEpidemiology
Definition: Tumors in bone arising from distant, non-bone source.
Vast majority of skeletal cancers are metastatic rather than primary.
30-70% of the roughly 563,700 people who die annually of cancer have bone metastasis.1
1. Coleman. Cancer Treatment Reviews. 2001;27:165-176.
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VCFs in Metastatic Cancer and Multiple Myeloma An estimated 75K-100K
cancer induced VCF occur annually in the U.S. Stage IV Breast1 and
Lung All Stages of Multiple
Myeloma2,3,4,5,6
Stage III and IV of Prostate7,8
1. Hortobagy et al, NEJM, Vol. 335, No. 24, ppg. 1785-17912. Berenson et al, NEJM, Vol. 334, No. 8, ppg. 488-4933. Brincker et al, British Journal of Haematology, 1998, V.101, ppg 280-2864. McCloskey et al, 1998, V.100, ppg 317-3255. Melton et al, V.20, No. 3, 2005, ppg 487-4936. Djulbegovic et al, The Cochrane Database of Systematic Reviews, 2002, Issue 4. Art. No.: CD003188, pg.1-327. Berruti et al, The Journal of Urology, Vol. 164, 0ct. 2000, ppg. 1248-12538. Diamond et al, Journal of Urology, Volume 172, pg. 529-532, August 2004
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Metastatic Bone DiseaseFractures
Patients with cancer are at elevated risk for osteoporosis and fractures both because of their disease and its treatment1
Metastatic cancer in the bone causes skeletal complications every 3 to 4 months.2
17 – 50% of patients with metastatic breast cancer will develop VCFs annually.3
Annual incidence of vertebral fracture is elevated 5-fold among women with newly diagnosed breast cancer1
36-fold among those with a soft-tissue recurrence of breast cancer, relative to women without breast cancer
Median time to first fracture among breast cancer patients (not on bisphosphonate) with at least one lytic lesion is 12.8 months.4
1. Theriault RL, The Oncology Report, 20062. Coleman RE. Ann Oncol. 2000;11:179-184. 3. Body. Cancer. 2003;97:859-865.4. Hortobagyi GN, Theriault RL, Lipton A, et al. J Clin Oncol. 1998;16:2038-2044.
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Metastatic Bone DiseaseLesion Types
Osteoblastic Increased bone density Does not change bone strength but
decreases bone stiffness Common in prostate cancer patients
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Metastatic Bone DiseaseLesion Types
Osteolytic Decreases both bone strength and
density Common in patients with metastatic
cancer and multiple myeloma 70% of multiple myeloma patients present
with osteolytic involvement of the spine1
Higher risk for fracture than blastic lesions2
1. Lieberman, et al. Clinical Orthopaedics and Related Research. 2003;415S:S176-186.2. Patel, B. and DeGroot, H. Orthopedics Journal. 2001;24:612-7.
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Metastatic Bone DiseaseRadiographic Appearance of Skeletal Metastases1
1. Malawer, MM and Delaney, TF. Treatment of Metastatic Cancer to the Bone. Cancer: Principles and Practice of Oncology. 4th ed. Philadelphia: JB Lippincott; 1993:2225-2245
Breast Usually Usually Usually
Prostate Occasionally Usually
Urinary Bladder Usually Infrequently
Lung Usually Usually Occasionally
Thyroid Usually
Lytic Mixed Blastic
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Metastatic Bone DiseasePrognosis
Once bone metastasis occurs, prognosis is generally poor
Patients with longer median survival will require treatment for skeletal complications
1. Attal, et al. NEJM. 1996;335:91-97.2. Andre, et al. J of Clinical Oncology. 2004;22:3302-3308.3. Ryo, et al. Nihon Kokyuki Gakkai Zasshi. 1998;36:317-22.
Disease TypeMedian Survival (months)
Multiple Myeloma1 36 – 60
Breast2
(Years: 1994-2000)29*
Lung3 5*
* After disease metastasizes to bone
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Metastatic Bone DiseaseMetastasis Sites
Most common sites of metastasis1
Vertebra (69%) Pelvis (41%)
Femur/Hip (25%)
Skull (14%)
Median time from cancer
diagnosis to bone metastasis
is 30 months2
1. Malawer, MM and Delaney, TF. Treatment of Metastatic Cancer to the Bone. In: Devita VT, Hellman S, Rosenberg SA (eds). Cancer: Principles and Practice of Oncology. 4th ed. Philadelphia: JB Lippincott; 1993:2225-2245.
2. Paterson AGH, et al. J Clinical Oncology. 1993;11:59-65.
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Metastatic Bone DiseaseDiagnostic Tools1
Imaging X-ray
Will only show bone metastasis if the cancer has destroyed a majority of the bone1
Computed Tomography (CT) Scan Bone Scan Magnetic Resonance Imaging (MRI)
T1, T2 and STIR images are the most useful images to define the extent of spine involvement
Blood Tests Calcium level
Needle Biopsy
1. University of Washington School of Medicine, May 2007
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Metastatic Bone DiseaseClinical Sequelae
Tumor established in bone Bone pain Pathologic fracture
Vertebral compression fractures (VCFs) Long bones
Spinal cord compression Hypercalcemia
1. Roodman GD, NEJM, 350;16,2004
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Reduce pain Eradicate or reduce tumor when primary
tumors are involved Prevent neurologic complications Treat pathologic fractures and prevent
recurrent fracture
Metastatic Bone DiseaseTreatment Goals
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Surgery Open and minimally invasive
Radiation Therapy Chemotherapy Bisphosphonates Hormone Therapy Immunotherapy (Active and Passive)
Metastatic Bone DiseaseAvailable Treatments1
1. American Cancer Society, 2007
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Consequences of Untreated VCF
1. Gold DT, Silverman SL. The Downward Spiral of Vertebral Osteoporosis: Consequences. Designated by Cedar Sinai Medical Center Press, 20032. Podichetty, et al. Journal of Musculoskeletal Medicine. 2004;21:372-378.
Radiculopathy Spinal cord
compression
Neurological Consequences1,2
Compression of the abdominal contents
Early satiety, weight loss Kyphosis Decreased lung function Increased risk of death
from lung disease Spinal instability Risk of more fractures
Biomechanical Consequences1,2
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Consequences …
Chronic pain Increased
dependence Decreased ability for
activities of daily living
Partial to complete immobility
Functional Consequences1,2
Depression or clinical anxiety or both
Sleep disorder
Psychological Consequences1,2
1. Gold DT, Silverman SL. The Downward Spiral of Vertebral Osteoporosis: Consequences. Designated by Cedar Sinai Medical Center Press, 20032. Podichetty, et al. Journal of Musculoskeletal Medicine. 2004;21:372-378.
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Pain Assessment
Establish time course Constant Intermittent Both
Type of intermittent pain Breakthrough Incident End of dose failure
1. LeGrand, S. B., (2007, June). Developing an Index of Suspicion, Presentation at the International Multiple Myeloma meeting, Kos, Greece.
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Incident Pain
The most difficult to control Doses required may be significantly more
than the breakthrough/sustained release dose
May require PCA Often needs an intervention
Disease specific radiation therapy, chemotherapy Surgical stabilization
1. LeGrand, S. B., (2007, June). Developing an Index of Suspicion, Presentation at the International Multiple Myeloma meeting, Kos, Greece.
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Tumor-Related VCFsNon-Surgical Management1
Bisphosphonates Radiation Therapy Analgesics Bracing Bed rest
1. Yeh & Berenson, Clin Cancer Res. 2006, 10: 6279-6284.
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Tumor-Related VCFsEffects of Bisphosphonates
Metastatic bone cancer with lytic lesions Clodronate reduces the risk of VCFs by about 30%1
Multiple Myeloma Clodronate and pamidronate reduce the risk of VCFs by
25 – 45%2
Monthly IV infusions of either pamidronate or zoledronic acid have reduced the skeletal complications among patients with multiple myeloma3
Orally administered bisphosphonates have shown little ability to slow the development of skeletal complications in multiple myeloma3
1. Paterson, et al. J Clin Oncology. 1993;11:59-65.
2. Body, J. Supplement to Cancer. 2003;97:859-865. McCloskey EV, et al. British J of Haematology. 1998;100:317-325.
3. Yeh & Berenson, Clin Cancer Res. 2006, 10: 6279-6284.
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Chemotherapy Some regimens include prednisone, which can lead to
secondary osteoporosis and increase the risk for VCFs Radiation therapy
Conflicting evidence of the link between radiation and incidence of VCFs
Does not prevent fracture progression1
Does not correct the anatomic abnormality from fracture2
1. Tong et al. Cancer. 1982;50:893-899. 2. Janjan, N. Seminars in Oncology. 2001;28:28-34.
Tumor-Related VCFsEffects of Chemotherapy and Radiation Therapy
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Open Surgical Procedures Vertebral column reconstruction Anterior or Posterior decompression with internal
fixation Oncology patients are generally poor candidates for
open surgery due to soft bone/tumor mass and co-morbidities
Minimally Invasive Procedures1
Balloon Kyphoplasty Vertebroplasty
Tumor-Related VCFsSurgical Management
1. Yeh & Berenson, Clin Cancer Res. 2006, 10: 6279-6284.
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Multiple MyelomaEpidemiology Estimated 19,970+ new
cases in 2007 – about 1% of all new cancer cases1
Estimated 75,000 – 100,000 living with multiple myeloma in US2
Typically afflicts the elderly, males, and more African-Americans than Whites by 2:13
Estimated 11,000 deaths from multiple myeloma in 2007 – about 2% of all deaths from cancer1
0
10
20
30
40
50
60
Age
Inci
denc
e (C
ases
/ 10
0,00
0)
Men
Women
1. American Cancer Society, Cancer Facts and Figures 20072. Durie B, International Myeloma Foundation, 2006. 3. Sirohi, et al. The Lancet. 2004;363:875-887.
Source: SEER 1975-2001, National Cancer Institute
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Multiple MyelomaPathology1,2
Abnormal plasma cells proliferate in bone marrow Compromises immune function Disrupts bone marrow function Hypergammaglobulinemia end-organ damage (primarily
renal failure) Activation of osteoclasts Decline in osteoblast activity
1. Roodman GD, NEJM, 350;16,20042. Yeh & Berenson, Clin Cancer Res. 2006, 10: 6279-6284.
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Multiple MyelomaFractures
Over 70% of patients have bone pain at diagnosis and half have back pain1
55 - 70% have VCFs or history of vertebral body abnormalities2
15 - 30% develop new VCFs annually3 About half of patients with at least one osteolytic
lesion develop pathologic fractures within nine months4
1. McClosekey, et al. Br J Hematol. 1998;100:317-325.2. Ray et al. J Bone Mineral Research. 1997;12:24-35.3. McCloskey, et al. Drugs. 2001;61:1253-1274.4. Berenson, et al. NEJM. 1996;334:488-493.
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Multiple MyelomaExample of VCF
T-10 Fracture Due to Multiple Myeloma
Courtesy of Steve James, M.D.
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Tumor-Related VCFsVertebroplasty vs. Balloon Kyphoplasty
Vertebroplasty Balloon Kyphoplasty
Fracture Reduction
Postural Reduction Inflatable Bone Tamp
Cavity Creation -- Inflatable Bone Tamp
Cement Injection
High pressure injection into interstices
Low pressure fill into cavity created by IBT
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Aimed at stabilizing the FractureAimed at stabilizing the Fracture and Correcting Correcting Spinal DeformitySpinal Deformity caused by VCFs
Tumor-Related VCFsBalloon Kyphoplasty
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Aimed at restoring height and stability in fractured
vertebral body
Treating pain related to vertebral collapse
Tumor-Related VCFsBalloon Kyphoplasty Treatment Goals
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Minimally invasive Bilateral, 1 cm incisions
Typically one hour per treated fracture General or local anesthesia (supplemented by
conscious sedation) May require an overnight hospital stay
Tumor-Related VCFsBalloon Kyphoplasty Procedure
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The Inflatable Bone Tamp is inserted into the fractured vertebral body
Fracture Reduction & Void CreationOverview of Treatment Steps for VCFs
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The balloon is inflated, elevating the endplates and restoring vertebral body height
Fracture Reduction & Void CreationOverview of Treatment Steps for VCFs
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The balloon is deflated and withdrawn, leaving a cavity within the vertebral body
Fracture Reduction & Void CreationOverview of Treatment Steps for VCFs
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The void is filled with the surgeon’s choice of material, creating an “internal cast”
Fracture Reduction & Void CreationOverview of Treatment Steps for VCFs
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KYPHON® Balloon Kyphoplasty:
Clinical Outcomes for Oncology Patients
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Percutaneous Vertebroplasty and Balloon Kyphoplasty for Painful Vertebral Body Fractures
in Cancer Patients
Authors: Fourney et al J. Neurosurg (Spine 1). 2003;98:21-30.
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Fourney Study Parameters
56 patients 21 with multiple myeloma 35 with bone metastases
97 levels treated 32 with balloon kyphoplasty 65 with vertebroplasty
All patients had intractable pain due to VCFs Median duration of symptoms 3.2 months
Mean follow-up 4.5 months
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Fourney StudyOutcomes (15 Patients treated with balloon kyphoplasty alone)
Balloon Kyphoplasty provides sustained pain reduction.
0
1
2
3
4
5
6
7
8
9
Preop Postop 1 month 3 month 6 month 1 year
Time of Assessment
Me
dia
n S
elf
-Ra
ted
VA
S P
ain
Sc
ore
Results for all time intervals were statistically significant vs baseline. P<0.05
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Fourney StudyOutcomes
Marked or complete pain relief in 49/58 procedures (84%) 2 patients underwent repeat procedures for new
fractures No change in 5 procedures
Cement extravasation 9.2% in vertebroplasty (asymptomatic) 0% in balloon kyphoplasty
42% mean height restoration after balloon kyphoplasty
Reduced analgesic use in follow-up
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Balloon Kyphoplasty Enhances Function and Structural Alignment in Multiple Myeloma
Authors: Lane et al Clinical Orthopaedics and Related Research.
2004;426:49-53.
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Lane StudyParameters
19 patients with multiple myeloma Total of 46 levels treated with balloon
kyphoplasty
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Lane StudyOutcomes
16 of 19 patients showed improvement in Oswestry Disability Index (ODI) scores Mean score improved from 49 to 33 (p <
0.001) Partial restoration of anterior vertebral
body height in 76% of vertebral bodies No complications Results were similar to a comparison
group of patients with osteoporotic VCFs
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Vertebroplasty and Balloon Kyphoplasty for Osteolytic Vertebral Collapse
Authors: Lieberman and Reinhardt Clinical Orthopaedics and Related Research.
2003;415(S):176-186.
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Lieberman and Reinhardt StudyParameters
63 patients with osteolytic collapse 52 with multiple myeloma 11 with osteolytic metastases
264 vertebral bodies treated with balloon kyphoplasty
Mean follow-up 18 weeks in multiple myeloma patients 3 weeks in patients with metastases
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Lieberman and Reinhardt StudyMyeloma Patient Outcomes
Visual Analog Scale
6.18
2.84
0
1
2
3
4
5
6
7
pre-op post-op
Mea
n S
elf-
Rat
ed P
ain
(0
to 1
0)
0 = no pain
p<0.0001
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Oswestry Disability Index
46.7
30.33
0
5
10
15
20
25
30
35
40
45
50
pre-op post-op
Mea
n S
core
Lower score = better physical functionP=0.0001
Lieberman and Reinhardt StudyMyeloma Patient Outcomes
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SF-36 Scores
0102030405060708090
PF RP BP V SF RE MH GH
Pre-op
Post-op
*Balloon Kyphoplasty provides statistically significant improvement in Bodily Pain and Physical Function as measured in SF-36 scores.
P<0.0001* P=0.043 P=0.0003* P=0.683 P=0.043 P=0.016 P=0.806 P=0.008
Lieberman and Reinhardt StudyMyeloma Patient Outcomes
Physical Mental General Health
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“Less than 5%” asymptomatic leaks in 264 vertebral bodies treated
No symptomatic cement leaks
Lieberman and Reinhardt StudyMyeloma Patient Outcomes
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Balloon Kyphoplasty has statistically significant lower overall procedure-related and cement-related complication rates compared to vertebroplasty!
Total Procedure-related
Complications
Cement-Related Complications
Access-Related Complications
Non-device Related
Complications
Balloon KyphoplastyN = 1947 patients
14(0.7%)
3(0.2%)
4(0.2%)
7(0.4%)
VertebroplastyN = 6808 patients
199(2.9%)
132(1.9%)
28(0.4%)
39(0.6%)
p-value of difference 0.0002 <0.0001 0.3791 0.8781
Kyphon’s Meta-analysis: Results
1. Kyphon’s meta-analysis: Quantitative Analysis of Perioperative Complication Rates in Balloon Kyphoplasty and Vertebroplasty, completed December 2006 (PN 95000047)
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0.8%
0%
2.8%
3.4%
0%
1%
2%
3%
4%
Osteoporotic Cancer
Ove
rall
Proc
edur
e-Re
late
dCo
mpl
icat
ion
Rate
Balloon Kyphoplasty
Vertebroplasty
Kyphon’s Meta-analysis:Osteoporosis & Cancer Sub-analysis of
VCFs due to osteoporosis or cancer
Procedure-related complications are statistically significantly lower for Balloon Kyphoplasty than Vertebroplasty in both indications
p = 0.0042 p = 0.0072
5581patients
1770patients
1227patients
177patients
1. Kyphon’s meta-analysis: Quantitative Analysis of Perioperative Complication Rates in Balloon Kyphoplasty and Vertebroplasty, completed December 2006 (PN 95000047)
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Balloon Kyphoplasty and Vertebroplasty for Vertebral Compression Fractures: A Comparative Systematic Review of
Efficacy and Safety
Authors: Taylor RS, Taylor RJ, Fritzell P Spine 2006;31:2747–2755
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Cement Leakages per Vertebra(data from Table 6, Taylor - Spine 2006)
8%
0%
40.0%
3%
0%
10%
20%
30%
40%
50%
Overall Symptomatic
Balloon Kyphoplasty
Vertebroplasty
Taylor Study*: Systematic Literature Review Cement Leakage ResultsCase series comparison:Balloon Kyphoplasty has a lower rate of cement extravasation than Vertebroplasty
p < 0.0001BK: 90/1111 = 8%VP: 614/1551 = 40%
(p-value not reported)BK: 0/1094 = 0%VP: 8/275 = 3%
*Includes fracture of all etiologies
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Adverse Events per Patient(data from Table 6, Taylor - Spine 2006)
0.3%0%
0.3%
1.8%
0.5%
2.5%
0.0%
1.0%
2.0%
3.0%
4.0%
Pulmonary embolism Spinal cordcompression
Nerve root pain/radiculopathy
Balloon Kyphoplasty
Vertebroplasty
Taylor Study: Systematic Literature Review Adverse EventsCase series comparison:Balloon Kyphoplasty has a lower complication rate than Vertebroplasty
BK: 1/291 = 0.3%VP: 15/803 = 1.8%
BK: 0/195 = 0%VP: 3/631 = 0.5%
BK: 1/322 = 0.3%VP: 32/1100 = 2.5%
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Vertebroplasty and Balloon Kyphoplasty: A Systematic Review of 69 Clinical Studies
Authors: Hulme PA, Krebs J, Ferguson SJ, Berlemann U
Spine. 2006;31:1983-2001
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Balloon Kyphoplasty has a lower rate of overall complications and total cement leakages than Vertebroplasty
Total Cement Leakage
(per vertebra)
Clinical Complications(per vertebra)
ClinicalComplications
(per patient)
Pulmonary Embolism
(per vertebra)
Neurologic(per vertebra)
BalloonKyphoplasty
(n = 1288)9% 1.3% 2.2% 0.01% 0.03%
Vertebroplasty(n = 2958) 41% 2.6% 3.9% 0.6% 0.6%
Hulme Study: Systematic Literature Review
(Data from Figure 4, Hulme – Spine 2006)
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Percutaneous vertebroplasty and balloon kyphoplasty for the treatment of osteoporotic vertebral
compression fractures and osteolytic tumours
Authors: Hadjipavlou AG, Tzermiadianos MN, Katonis PG, Szpalski M
J. Bone Joint Surg Br. 2005;87:1595-1604
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Hadjipavlou Study*: Systematic Literature Review
Location of Cement Extravasation
8.4%
1.2%4.0% 4.6%
29.0%
10.7%8.4%
5.0%
0%0%
6.0%
0.6%
0%
5%
10%
15%
20%
25%
30%
35%
TOTAL
Epidur
al
Foram
inal
Intra
disca
l
Paras
pinal
Intra
veno
us
Pe
rce
nta
ge
Balloon Kyphoplasty (n = 1279 vertebral bodies)
Vertebroplasty (n = 2729 vertebral bodies)
Systematic review of studies published between 1983 and September 2004 BK has lower cement leakage rates than VP
*Includes fracture of all etiologies
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Summary of LiteratureAdverse Events
No reported complications related to balloon kyphoplasty for tumor-related VCFs
Complications during balloon kyphoplasty for osteoporotic VCFs have been reported
Complication rate < vertebroplasty
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Kyphon CAFE Study
Cancer Fracture Evaluation Objective: Determine benefit of
balloon kyphoplasty vs. non-surgical treatment in tumor-related VCFs with respect to function and pain
Multicenter randomized clinical trial N=200 Primary endpoint: Roland Morris
Disability Questionnaire score @ 30 days
1-year follow-up
Note: Post Marketing Study Following Cleared Indications for Use
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Indications for UseNot Investigational – Indicated for Cancer-Related Fractures KYPHON® HV-R™ Bone Cement was originally cleared for
marketing in the United States in 2004 for treatment of pathologic VCFs using a balloon kyphoplasty procedure Indicated for the treatment of pathological fractures of the
vertebral body due to osteoporosis, cancer, or benign lesions using a balloon kyphoplasty procedure. Cancer includes multiple myeloma and metastatic lesions, including those arising from breast or lung cancer, or lymphoma. Benign lesions include hemangioma and giant cell tumor.
KYPHON® Inflatable Bone Tamps were originally cleared for marketing in the United States in 1998 Intended to be used as conventional bone tamps for the
reduction of fractures and/or creation of a void in cancellous bone in the spine (including use during balloon kyphoplasty with KYPHON® HV-R™ Bone Cement), hand, tibia, radius and calcaneus.
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Adverse Events
Any type of surgery involves risk. Although the complication rate for balloon kyphoplasty is low, serious adverse events, some of which can be fatal, can occur, including myocardial infarction (heart attack), cerebrovascular accident (stroke), pulmonary embolism (blood, fat or cement clot that migrates to the lungs), and cardiac arrest (heart stops beating).
Other risks (relevant to the anatomy being treated) include deep or superficial wound infection, leakage of bone cement into the muscle and tissue surrounding the spinal cord and nerve injury that can, in rare instances, cause paralysis. Patients are encouraged to discuss these and other risks with their physician.
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Disclosure
• The physicians referenced may be paid consultants of, and research cited may have been funded partially or in whole by, Kyphon Inc.
• Although the complication rate with Balloon Kyphoplasty has been demonstrated to be low, as with most surgical procedures, there are risks associated with Balloon Kyphoplasty, including serious complications. For complete information regarding indications for use, warnings, precautions, adverse events and methods of use, please reference the devices’ Instructions for Use.
• Kyphon and KyphX are registered trademarks, and HV-R and Ahead of the Curve are trademarks of Kyphon Inc.
• © 2007 Kyphon Inc. All rights reserved.
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References1. American Cancer Society, Cancer Facts and Figures, 20072. American Cancer Society, Types of Treatment, 20073. Andre F, et al. (2004) Breast Cancer with Synchronous Metastases: Trends in Survival during a 14-Year Period. J of Clin Oncology 22:3302-33084. Attal M, et al. (1996) A Prospective, Randomized Trial of Autologous Bone Marrow Transplantation and Chemotherapy in Multiple Myeloma.
NEJM 335:91-975. Berenson, et al. (1996) Efficacy of Pamidronate in Reducing Skeletal Events in Patients with Advanced Multiple Myeloma. NEJM 334:488-4936. Berruti et al, "Incidence of Skeletal Complications in Patients with Bone Metastatic Prostate Cancer and Hormone Refractory Disease", The
Journal of Urology, Vol. 164, 0ct. 2000, ppg. 1248-12537. Brincker et al, "Failure of oral pamidronate to reduce skeletal morbidity in multiple myeloma: a double-blind placebo controlled trial", British
Journal of Haematology, 1998, V.101, ppg 280-2868. Body, Jean-Jacques (2003) Effectiveness and Cost of Bisphosphonate Therapy in Tumor Bone Disease. Cancer Supplement 97:859-8659. Coleman, R.E. (2001) Metastatic Bone Disease: Clinical Features, Pathophysiology and Treatment Strategies. Cancer Treatment Reviews
27:165-17610. Coleman, R.E. (2000) Uses and Abuses of Bisphosphonates. Ann Oncol. 11:179-184. 11. Diamond et al, "Osteoporosis and Spinal Fractures in Men with Prostate Cancer: Risk Factors and Effects of Androgen Deprivation Therapy",
Journal of Urology, Volume 172, pg. 529-532, August 200412. Djulbegovic et al, "Bisphosphonates in multiple myeloma (Review)", The Cochrane Database of Systematic Reviews, 2002, Issue 4. Art. No.:
CD003188, pg.1-3213. Durie B, “Understanding Balloon Kyphoplasty and Myeloma-Induced Vertebral Compression Fractures”, International Myeloma Foundation, June
2006, P 1614. Fourney D., et al. (2003) Percutaneous Vertebroplasty and Kyphoplasty for Painful Vertebral Body Fractures in Cancer Patients. J Neurosurg
(Spine 1) 98:21-3015. Gold DT, Silverman SL. The Downward Spiral of Vertebral Osteoporosis: Consequences. Designated by Cedar Sinai Medical Center Press, 200316. Hadjipavlou et al, “Percutaneous vertebroplasty and balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures and
osteolytic tumours, J. Bone Joint Surg Br. 2005;87:1595-160417. Hortobagyi GH, et al. (1996) Efficacy of Pamidronate in Reducing Skeletal Complications in Patients wit Breast Cancer and Lytic Bone
Metastases. NEJM 335:1785-179118. Hortobagyi GN, Theriault RL, Lipton A, et al. (1998) Long-term Prevention of Skeletal Complications of Metastatic Breast Cancer with
Pamidronate. J Clin Oncol.16:2038-204419. Hulme et al, “Vertebroplasty and Kyphoplasty: A Systematic Review of 69 Clinical Studies”, Spine. 2006;31:1983-200120. Janjan N. (2001) Bone Metastases: Approaches to Management. Seminars in Oncology 28:28-3421. Kyphon Data on File. Literature review conducted as of July, 2004, Kyphon Prospective Study.
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References Continued22. Lane J, et al. (2004) Kyphoplasty Enhances Function and Structural Alignment in Multiple Myeloma. Clinical Orthopaedics and Related
Research Sep(426):49-5323. LeGrand, S. B., (2007, June). Developing an Index of Suspicion. Presentation presented at the meeting of the International Multiple
Myeloma, Kos, Greece.24. Lieberman I. and Reinhardt M.K. (2003) Vertebroplasty and Kyphoplasty for Osteolytic Vertebral Collapse. Clinical Orthopaedics and
Related Research (415S):S176-S18625. Malawer, MM and Delaney, TF. Treatment of Metastatic Cancer to the Bone. In: Devita VT, Hellman S, Rosenberg SA (eds). Cancer:
Principles and Practice of Oncology. 4th ed. Philadelphia: JB Lippincott; 1993:2225-224526. McCloskey, et al. (2001) The Clinical and Cost Considerations of Bisphosphonates in Preventing Bone Complications in Patients with
Metastatic Breast Cancer or Multiple Myeloma. 61:1253-127427. McCloskey, et al. (1998) A Randomized Trial of the Effect of Clodronate on Skeletal Morbidity in Multiple Myeloma. British J. Hemtaol.
100:317-325.28. Melton et al, "Fracture Risk with Multiple Myeloma: A Population-based Study", V.20, No. 3, 2005, ppg 487-49329. Patel, B. and DeGroot, H.(2001) Evaluation of the Risk of Pathologic Fractures Secondary to Metastatic Bone Disease.Orthopedics Journal.
24:612-7.30. Paterson AGH, et al. (1993) Double-Blind Controlled Trial of Oral Clodronate in Patients with Bone Metastases from Breast Cancer. J
Clinical Oncology;11:59-6531. Podichetty V., et al. (2004) Managing Vertebral Compression Fractures and Multiple Myeloma in Older Patients. J of Musculoskeletal
Medicine 21:372-37832. Ray et al. (1997) Medical Expenditures for the Treatment of Osteoporotic Fractures in the U.S. in 1995: Report from the National
Osteoporosis Foundation. J Bone Mineral Research;12:24-3533. Roodman et al, “Mechanisms of Bone Metastases”, NEMJ, 2004;350:1655-64.34. Ryo, et al. (1998) Bone Metastasis of Primary Lung Cancer. Nihon Kokyuki Gakkai Zasshi 36:317-2235. Sirohi, B. and Powles, R. (2004) Seminar: Multiple Myeloma. The Lancet 363:875-8736. Taylor et al, “Balloon Kyphoplasty and Vertebroplasty for Vertebral Compression Fractures: A Comparative Systematic Review of Efficacy
and Safety”, Spine 2006;31:2747–275537. Theriault et al, “Task Force Reports on Bone Health in Patients with Cancer”, The Oncology Report, 200638. Tong D., et al. (1982) The Palliation of Symptomatic Osseous Metastases: Final Results of the Study by the Radiation Therapy Oncology
Group. Cancer 50:893-89939. University of Washington School of Medicine, “When Cancer Spreads to the Bone: Surgery for Metastatic Bone Disease”, 2007, 40. Yeh & Berenson. Treatment of Myeloma Bone Disease. Clinical Cancer Res (2006). 10: 6279-6284