Transcript
2003 Fused pyridine derivatives
Fused pyridine derivativesR 0450 2-Aryl-3-arylaminoisoxazol-5(2H)-ones as Sources of Indoles and Imid-
azo[1,2-a]pyridines. — Intramolecular cyclization of isoxazolones (II) in the presence of a base gives fused pyridines exclusively, whereas under the same conditions isox-azolones (IV) afford additionally indoles. The mode of cyclization is controlled by the electronegativity of the aryl substituent. Compounds (Vb) and (VIb) exhibit significant cytotoxicity toward mammalian cells. — (JEFFERY, D.; PRAGER*, R. H.; TURNER, D.; DREIMANIS, M.; Tetrahedron 58 (2002) 50, 9965-9972; Sch. Chem., Phys. Earth Sci., Flinders Univ., Adelaide, South Aust. 5001, Australia; Eng.) — Klein
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