2
High Resolution T2 ImagingRat versus Mouse
T1 MP-RAGE
Dark CSF
Resolution Rat: 156 x 156 x 700 µm3
Mouse: 138 x 117 x 400 µm3
Coil setup:Transmit: Integrated body coilReceive: Dedicated brain 2x2 array
3
T2 Imaging
Rat brain
TSE, magnetization restoreTR: 2000 msTE: 38 msTot. scan time: 3 min 10 sFoV: 35 x 35 mm² Slice thickness: 0.8 mmMatrix: 240 x 320Resolution: 146 x 109 µm2
Coil setup:Transmit: Integrated body coil Receive: Rat brain
quadrature coil
T2 imaging
Bright CSF
BGA12S
T2 Map T2
1.2 x 0.182 x 0.182 mm3
Traumatic Brain Injury
T2 image of injured Rat spine
Spine Injury
Rat Thoracic Spine
Fiber tracking rat spine – T2 backgroundpost injury
Diffusion Tensor Imaging
Fiber tracking mouse brain
Pre injury
Post injury
Gadolinium-tagged drug in Nasal Passage fMRI
segmentationMouse spine
angiography
Rat knee
9
Mouse Spine with the MRI CryoProbe™
Turbo-RARE-T2TR: 1000 ms Slice thickness: 0.5TE: 12.6 ms Res.: 46 x 46 µm²Matrix: 384 x 384 NA: 2Total time 6 min. 24 sec.
10
• Specific animal beds:rat, mouse, rabbit
• Integrated animal warming
• Stereotactic fixation
Animal handling
Cryocoil bed
Mouse Cardiac Coil Rat Body/Cardiac Coil
Mouse and Rat Beds
Attached to bed
Dr Edward Hall
ADC
DWIRATSingleCoronalSlice117um x 238um x 1500um
“Qualitative” Analysis - T2 map, T1 map, ADC (DTI)
Rat Body/Cardiac CoilMouse Body Coil
Cryo-probe images – mouse brain• FLASH T2 * weighted• TE/TR: 22/350ms• Res.: 30x30x500µm• Scantime 6min• 9.4 T
2Cb
3Cb
5&4Cb6Cb
7Cb
8Cb
10Cb
9Cb
Gray matter:molecular layer
White matter
Gray matter:granular layer
Purkinje cell layer