Health Valley meets Health~Holland
10 September 2015
Personalized health(care) the Radboud approach
Alain van Gool Professor Personalized Healthcare Coordinator Radboudumc Technology Centers E: [email protected]
Radboud university medical center
• Nijmegen, The Netherlands
• Mission: “To have a significant impact on healthcare”
• Strategic focus on Personalized Healthcare through “the patient as partner”
• Core activities:
• Patient care
• Research
• Education
• 11.000 colleagues
• 52 departments
• 3.300 students
• 1.000 beds
• First academic centre outside US to fully implement EPIC
Strategy Radboudumc – our focus areas
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www.radboudumc.nl
Patient
Radboud Personalized Healthcare
A significant impact
on healthcare
Molecule
Population
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Personalized Healthcare @ Radboudumc
People are different Stratification by multilevel diagnosis
+ Patient’s preference of treatment
Exchange experiences in care communities Select personalized therapy
Population
Man
Molecule
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Example: Personalized healthcare in sepsis
• Sepsis (systemic inflammatory response to infection) • Major cause of death in hospitals in EU and US, with mortality up to 20-40% • No specific treatment is available • Focus on immune-based mechanisms as solution towards therapy
Molecule • Molecular function of inflammatory mediators (cytokines) • Role in host defense and organ damage
Man • Diagnose capacity blood cells to produce cytokines • Individualized sepsis therapy optimally targeting patient’s immune system
Population • Cross-patient analysis of cytokine production and severity of sepsis • Design/evaluate personalized immunotherapies
prof Mihai Netea
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Example: Personalized healthcare in Parkinson’s
Patient
Caregiver
Insurer
Self-monitoring
Patient
Caregiver
Insurer
Participatory
research
prof Bas Bloem dr Marten Munneke
Research themes and institutes
www.radboudumc.nl/Research/Themes/Pages/default.aspx
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Orientation across the spectrum from molecule to man to population
Ori
enta
tio
n a
cro
ss
the
spec
tru
m o
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isea
ses
PI
Research theme
Te
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olo
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C
ente
rs
Research support by Technology Centers
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www.radboudumc.nl/research/technologycenters
Genomics
Bioinformatics
Animal studies
Stem cells
Translational neuroscience
Image-guided treatment
Imaging
Microscopy
Biobank
Health economics
Mass Spectrometry
Radboudumc Technology
Centers Investigational
products
Clinical studies
EHR-based research
Statistics
Human performance
Data stewardship
Molecule
Flow cytometry
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About 250 dedicated people working in 18 Technology Centers, ~1600 users (internal, external), ~140 consortia www.radboudumc.nl/research/technologycenters/
• Proteins • Metabolites • Drugs • PK-PD
• Preclinical • Clinical
• Behavioural • Preclinical
• Animal facility • Systematic review
• Cell analysis • Sorting
• Pediatric • Adult • Phase 1, 2, 3, 4
• Vaccines • Pharmaceutics • Radio-isotopes • Malaria parasites
• Management • Analysis • Sharing • Cloud computing
• DNA • RNA
• Internal • External
• Early HTA • Evidence-based
surgery • Field lab
• Statistics • Biological • Structural
• Preclinical • Clinical • Economic
viability • Decision
analysis
• Experimental design • Biostatistical advice
• Electronic Health Records • Big Data • Best practice
• In vivo • Functional
diagnostics
• iPSC • Organoids
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Working together on the Radboud campus
(Spin-out) companies
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Radboud Research Facilities Shared facilities network across Radboud campus, also made part of Gelderland facilities Funding: 6.2M Eur provincie Gelderland + 6.2M Eur Radboud University/Radboudumc)
www.ru.nl/radboudresearchfacilities/ 13
Working with other Technology Networks Region, nation, Europe, world
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Working through multi-partner projects
Standardisation, harmonisation, knowledge sharing needed in:
1. Assay development
2. Clinical validation
Example: Biomarker Development Center
Roadmap Molecular Diagnostics (2012) Grant 4.3M Eur (2014)
Move towards EU funding (2016)
Prof Alain van Gool Prof Ron Wevers Prof Cees Tack
Working through spin-off companies (LS&H portefeuille Radboud Holding BV)
Pansynt B.V.
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Working through spin-off companies Example: MITeC
www.mitec.nl
Field lab environment for innovations in image-guided surgery. Joined enterprise of several departments of Radboudumc. Applied scientific collaboration with companies for joined product evaluation and development.
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A self-sustaining technology platform to manufacture radiopharmaceuticals for translational imaging. Cyclotron, laboratories and GMP-compliant production facility, also accessible for external users. 14M Eur investment, including 8M Eur European Fund for Regional Development (EFRO) subsidy.
www.radboudtranslationalmedicine.nl/
Example: Radboud Translational Medicine
Working through spin-off companies
Contract Manufacture: A reliable supplier of radiopharmaceuticals for nuclear diagnostic patient care at Radboudumc and other hospitals
Research: Develop new radiotracers for molecular imaging in preclinical and clinical research Part of Radboudumc Technology Centers
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Working through global innovators
Exponential technologies
Digital medicine
Integrated care
Artifical intelligence
Robotics Patients included
Lifestyle
Self quantification
Global health
Watson Artifical intelligence
Regenerative medicine
23andme
Robotics
Example: Singularity University’s Faculty
Lucien Engelen, REshape Innovation Center 19
Takehome message
• Strategic focus on implementing Personalized Healthcare
• Strong technological and methodological infrastructure
• Continuous exploration of functional networks
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