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40 anni di CRRT dal passato al futuro
Department of Nephrology Dialysis and Transplantation
International Renal Research Institute
St. Bortolo Hospital
Vicenza - Italy
Claudio Ronco
Vicenza, 9 aprile 2018
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First CAVH Treatment in Vicenza, 1977
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Severity of illness
Critical Care Nephrology
Ultra Specialistic
Common but low interaction
Interaction
Ultra Specialistic
Clinically
Specific
Clinically
Specific
I C U RENAL
I C U RENAL
Specialistic Specialistic
Interaction High
Interaction Moderate
Interaction Moderate
FROM SPECIALITY-ORIENTED TO PATIENT-ORIENTED
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40 years of CRRT
1977 First CAVH
In Gottingen and
First CAVH in Vicenza
Fourth generation
CRRT machines
2017
Third generation
CRRT machines,
Tr. of Sepsis HVHF &
HCO Membr.
2002
1995 Second
generation CRRT
machines CVVH
CVVHD CVVHDF
and studies on Dose & Adequacy
35 ml/Kg/h
1990
First generation
CRRT machines
CVVH CVVHD
CVVHDF
Lung support ECCO2R Citrate
anticoagulation Sorbents
2010
2005 Liver support MOST, CPFA
CVVH CVVHD
and Adoptive
Technology
1986
1983
CAVHD CAVHDF
Fluid Balance systems
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Techniques
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MOST
and
ECOS
Sepsis
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First Adult CAVH in Vicenza 1977 First Neonate CAVH in Vicenza 1982
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40 years of Pediatric CRRT
1977 Search fo minifilters
And visit to Amicon
Pediatric circuits in
adult machines
2002
First circuit for CAVH in
neonate
1981
1979
In Vitro Studies on minifilters and new
fiber
1988 CAVH + ECMO Uf control S. Mini Filter plus and
First CAVHD
2008 Prototypes
and drawing of a neonatal
machine
New project CARPEDIEM
2010
CVVH-D PE - BE
2017 1982
First world treatment of neonate with CAVH In Vicenza
2013
First world treatment
with CE-Marked CARPEDIEM licensed for human use
Vicenza 2013
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From a sketch and project to the Final Machine
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Filter Life
Treatment Downtime
Prescribed & Delivered Dose
Fluid Removal Parameters
Alarm Management
Summary
Machine Data Only
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Timing of CRRT Initiation
Fluid Overload and Management, Ventilator and Vasopressor Duration
CRRT Initiation versus KDIGO AKI Stage
Frequency of RRT After CRRT
Summary
Machine & EMR Data
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Teamwork & Technology in CRRT