5656
5757
Faculty Research
Highlights
2006
11
CORE FACULTY MEMBERSAssoc Professor Ang
Siau
GekAsst Professor Ryan PA BettensInstructor Dr Chanbasha
BasheerProfessor Chan Sze
On HardyAsst Professor Chen Ping
(joint with Physics)Assoc Professor Chin Wee ShongAssoc Professor Chuah
Gaik
KhuanAsst Professor Fan Wai
YipSnr
Research Fellow Dr Goh
Lai YoongProfessor Goh
Suat
HongAssoc Professor Leslie J Harrison Professor Hor
Tzi
Sum Andy (Head)Research Fellow Dr Huynh Han VinhAsst Professor Huang DejianAssoc Professor Stephan JaenickeAssoc Professor Kang Hway
ChuanAssoc Professor Stephan KasapisAssoc Professor Khoo
Soo
BengAssoc Professor Khor
EugeneAssoc Professor Lai Yee HingAsst Professor Lam YulinAsst Professor Martin J LearLecturer Dr Adrian M LeeProfessor Lee Hian
Kee
(Dy
Head)Lecturer Dr Leong
Lai PengAssoc Professor Leong
Weng
KeeProfessor Li Fong Yau
SamAssoc Professor Li TianhuAsst Professor Liu XiaogangAssoc Professor Loh Kian Ping (Dy
Head)Asst Professor Lu YixinLecturer Dr Mak
Ka Wai
KarenResearch Fellow Dr Maung
Maung
Saw
(joint with Diagnostic Radiology, Medicine)Asst Professor David G PopovichLecturer Dr Ship Chee
PingAsst Professor Sim
Wee Sun
Asst Professor Tan Choon
HongAsst Professor Toh
Chee
SengAssoc Professor Valiyaveettil
SureshAssoc Professor Jagadese
J VittalResearch Fellow Dr Weng
ZhiqiangAsst Professor Thorsten
WohlandAssoc Professor Wong Ming Wah
Richard
(Dy
Head)Professor
Xu
Guo
QinAsst Professor Xu
Qing‐HuaAsst Professor Xue
FengAssoc Professor Yao Shao Qin (Asst Head)
(joint with Biological Sciences) Assoc Professor Yip Hon Kay John
(Asst Head)Asst Professor Zeng
HuaqiangResearch Fellow Dr Zhao JinAssoc Professor Zhou Weibiao
22
Emeritus Professor Ang
How GheeEmeritus Professor Huang Hsing
HuaEmeritus Professor Kiang Ai Kim
Adjunct Professor Bosco
Bloodworth
(Health Sciences Authority)Adjunct Assoc Professor Anthony D Buss (Merlion
Pharmaceuticals)Adjunct Asst Professor Mark S Butler (Merlion
Pharmaceuticals)Adjunct Asst Professor Chan Ping Kwong
Peter (Polymer Coating Technologies)Adjunct Asst Professor Thomas Keller (Novartis
Institute of Tropical Diseases)Adjunct Research Fellow Dr Koh
Lip LinAdjunct Assoc Professor Lan
Weiguang
(Sinomem Technology Ltd) Adjunct Assoc Professor Joseph I Rasiah
(PerkinElmer Singapore)Adjunct Assoc Professor Sun Tak
On Eric (S*Bio)Adjunct Asst Professor Andrew Wan (Institute of Bioengineering and Nanotechnology)
Visiting
Professor Bahruddin
bin Saad
(Universiti
Sain
Malaysia)Visiting
Professor Chang Young Tae (New York University) Visiting
Professor Stuart Edelstein (University of Geneva) Visiting
Professor Franz Ekkehardt
Hahn (Westfalische
Wilhelms‐Universitat
Munster)Visiting Professor Robert Huber (Max‐Planck‐Institut
fh
r Biochemie) Visiting
Professor Lang Jianping
(Suzhou
University)Visiting
Professor Liu Ru‐Shi (National Taiwan University)Visiting
Professor Yoshio Ono (Tokyo Institute of Technology)Visiting
Fellow Dr Taewee
Tongdang
(Songkhla
University) Visiting
Professor Teoh
Siang
Guan (Universiti
Sains
Malaysia)Visiting
Senior Fellow Dr Christofora
Hanny
Wijaya
(Bogor
Agriculture University)Visiting
Fellow Dr Yu Long (Nanjing
University of Technology)
EMERITUS FACULTY
ADJUNCT FACULTY
VISITING FACULTY
33
Assoc Professor ANG Siau
GekPh.D., Cambridge Univ., 1987; M.Sc., National Univ. of Singapore, 1984;
B.Sc., National Univ. of Singapore, 1981
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/angsg.htm
Email: [email protected]
MAJOR RECOGNITION•
Chevalier in the Order of the Palmes
Academiques, French Ministry of Youth, Education and
Research, 2004
RESEARCH INTERESTSWe
study
structures
of
organic
and
organometallic
compounds
using
a
variety
of
spectroscopic
techniques
and
other
physical
techniques
including
X‐ray
diffraction
methods.
Specific
focuses
are:• Osmium and ruthenium cluster compounds containing Group 15 ligands• Fabrication of Organometallic
Nanostructures
RECENT HIGHLIGHTReference: Acta
Crystallographica, E62, m1329‐m1331 (2006)
The
title
compound,
[Os(C12
F10
N3
)2
(CO)3
has
been
synthesized
by
the
reaction
of
C6
F5
N=NNHC6
F5
with
H2
(Os)3
(CO)10
. The
OsC3
N3
coordination
is
octahedral
around the
Os
center. Two
bonding
modes,
chelating and
monodentate, are observed for the triazenyl
groups.
PREMIUM PUBLICATIONS•
B‐W Sun, M‐S Zhang, G‐Y Yang, SG Ang
and HG Ang, Decacarbonyl‐1κ3C,2κ3C,3κ4
C‐(μ‐pentafluorophenylhydrazine‐
1κN:2κN’)‐triangulo‐triosmium: a hydrazine‐edge‐bridged triangular triosmium
cluster, Acta
Crystallographica,
E61,
m2419‐m2420 (2005) •
HG
Huang,
CL
Xiang,
YS
Ning,
JY
Huang,
SG
Ang
and
GQ
Xu,
Dry
Synthesis
of
Triple
Cumulative
Double
Bonds
(C=C=C=N) on Si(111)‐7x7 Surfaces, Journal of Physical Chemistry B, 109(41), 19296‐19300 (2005) •
SG
Ang
and
B‐W
Sun,
Crystal
Structure
and
Characterization
of
Organic‐Inorganic
Hybridized
Molecules
with
Molecular Zipper Structures and Two‐Dimensional Grid Networks, Crystal Growth & Design, 5, 383‐386 (2005) •
SG
Ang,
B‐W
Sun
and
S
Gao, Synthesis,
crystal
structures
and
magnetic
properties
of
one‐
and
two‐dimensional
copper (II) complexes bridged by succinate, Inorganica
Chemistry Communications, 7, 795‐798 (2004) •
G‐Y Yang, S‐G Ang, LL Chng, YW Lee, EW‐P Lau, KS Lai and H‐G Ang, Synthesis and Nonlinear Optical Absorption
of Novel Porphyrin‐Osmium‐Cluster Complexes, Chem. Eur. J., 9(4), 900‐904 (2003)
44
Dr CHANBASHA BasheerPh.D., National Univ. of Singapore, 2005; B.Sc., Madras Univ. (India)
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/cb.htm
Email: [email protected]
RESEARCH INTERESTSMy
research
area
is
in
analytical
chemistry,
novel
materials
and
Lab‐on‐a‐Chip‐based
reaction
engineering.
Developing
simple
and
more
efficient
micro
analytical
procedures
for
environmental and biomedical applications. Specific focuses are:• Analytical Chemistry/Environmental Chemistry • Novel materials/Reaction Engineering in Microfluidics
PREMIUM PUBLICATIONS•
C Basheer,
AA Alnedhary, BSM Rao, S Valiyaveettil
and HK Lee, Development and application of porous membrane‐
protected
carbon
nanotube
micro‐solid‐phase
extraction
(μ‐SPE)
combined
with
gas
chromatography/mass
spectrometry, Anal. Chem., 78, 2853‐2858 (2006)•
C Basheer,
M Vetrichelvan,
S Valiyaveettil
and HK Lee,
Ionic‐liquid supported oxidation reactions
in a silicon‐based
microreactor, Tetrahderon. Lett., 47, 957‐961 (2006) •
C Basheer, H Wang, A Jayaraman, S Valiyaveettil
and HK Lee, Polymer‐coated hollow fiber microextraction
combined
with on‐column stacking in capillary electrophoresis, J Chromatogr. A., 1128, 267‐272 (2006) •
HSN Lee, C
Basheer
and HK Lee,
Determination of
trace
level
chemical
warfare
agents
in
water
and
slurry
samples
using
hollow
fibre‐protected
liquid‐phase
microextraction
followed
by
gas
chromatography–mass
spectrometry,
J.
Chromatogr. A. 1124, 91‐96 (2006) •
C
Basheer,
S
Sindhu,
S
Valiyaveettil
and
HK
Lee,
Development
and
application
of
simple
capillary‐microreactor
for
the heterogonous catalysis of glucose using porous gold (0) catalyst, Chem. Commun., 3, 409‐410 (2005)
55
Asst Professor Ryan P A BETTENSPostdoc., Australian National Univ., 1999; Postdoc., Ohio State Univ., 1996;
Postdoc., ETH, Zurich, 1994; Ph.D., Monash
Univ., 1992; B.Sc., Univ. of
Queensland, 1986
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/bettens.htm
Email: [email protected]
RESEARCH INTERESTSMy research area is in the understanding and describing accurately via computational chemistry
inter‐
and
intra‐molecular
interactions. Ultimately
the
understanding
and
description
will
be
applied to the dynamics of large systems like proteins and nucleic acids. Specific focuses are:• Accurately describe and predict enzyme‐substrate interactions• Reproduce and predict accurate nmr
spectra of proteins and other large molecules
PREMIUM PUBLICATIONS•
Y Fan, J Ho and RPA Bettens, Approximating coupled cluster level vibrational
frequencies with composite methods, J.
Phys. Chem. A, 110, 2796‐2800 (2006) •
RPA
Bettens,
Comparison
of
fundamental
and
harmonic
frequencies
of
first‐row
closed‐shell
diatomics,
J. Phys. Chem. A, 108, 1826‐1829 (2004) •
RPA
Bettens,
Bound
state
potential
energy
surface
construction:
Ab
initio
zero‐point
energies
and
vibrationally
averaged rotational constants, J. Am. Chem. Soc., 125, 584‐587 (2003) •
I
Medvedev,
M
Winnewisser,
FC
De
lucia,
E
Herbst,
E
Yi,
LP
Leong,
RPA
Bettens,
E
Biankowska‐jaworska,
O
Desyatnyk,
L
Pszczonkowski
and
Z
Kisiel,
The
millimeter‐
and
submillimeter‐wave
spectrum
of
the
trans‐trans
conformer of diethyl ether, Astrophysical J. Supp., 148, 593‐597 (2003) •
FL Bettens, RPA Bettens, RD Brown and PD Godfrey, The microwave spectrum, structure, and ring‐puckering of
the
cyclic dipeptide
diketopiperazine, J. Am. Chem. Soc., 122, 5856‐5860 (2000)
RECENT HIGHLIGHTReference: J. Phys. Chem. A, 110, 8777‐8785 (2006)
A
“black‐box”
method
for
fragmenting
molecules
as
large
as
proteins
into
a
significant
number
of
smaller
fragment
molecules
that
are
more
amenable
to
high‐
level
quantum
chemical
calculations
was
presented.
By
taking
an
appropriate
linear
combination
of
the
fragment energies, it is shown that it is possible in many
cases
to
obtain
highly
accurate
total
energies
when
compared to the total energy of the full molecule.
66
Professor CHAN Sze
On HardyPh.D., Univ. of Manchester Institute of Science & Technology, 1975; B.Sc.,
Southbank
Polytechnic, 1972
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chanhardy.htm
Email: [email protected]
RESEARCH INTERESTSMy
specific focuses are:• Functional polymers• Nanomaterials
RECENT HIGHLIGHTReference: J. Materials Chemistry, 15, 4161‐4166 (2005)
Y‐junction
polyaniline
(PANI)
nanorods
and
nanotubes
(40‐100
nm
in
diameter
and
a
few
micrometers
in
length)
were
prepared,
for
the
first
time,
using
self‐assembled
magnetic
nanoparticles
as
templates
and
pH
control
in
an
aqueous
medium.
The
morphologies
of
PANI
nanostructures (rods and tubes) were confirmed by TEM and the effect of reaction conditions on
the morphologies of PANI nanostructures was also studied.
PREMIUM PUBLICATIONS•
PKH Ho, BGT Tan, KL Tan, SC Ng and HSO Chan, Journal of the American Chemical Society, 117, 8517‐8523 (1995)•
HSO Chan and SC Ng, Progress in Polymer Science, 23, 1167‐1231 (1998)•
SC Ng, HF Lu and Chan HSO, Advanced Materials, 12, 1311‐1315 (2000)•
DM Cheng, HB Xia
and HSO Chan, Journal of Nanoscience
and Nanotechnology, 5, 466‐472 (2005)•
HB Xia, C Xiao and HSO Chan, Nanotechnology, 15, 1807‐1811 (2004)
77
Asst Professor CHEN PingPh.D., Xiamen
Univ., 1997; M.Sc., Xiamen
Univ., 1994; B.Sc., Xiamen
Univ.,
1991
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chenp.htm
Email: [email protected]
RESEARCH INTERESTSMy
specific focuses are:• Solid‐state Hydrogen Storage Materials • Synthesis and Characterization of ternary and multinary
nitrides, imides and amides • Heterogeneous catalysis
RECENT HIGHLIGHTOn‐board
hydrogen
storage
is
one
of
the
biggest
technical
challenges
in
the
global
energy
transition from fossil fuel to hydrogen energy. Novel Metal‐N‐H system has been developed for
hydrogen storage in the team since 2001. Reversible H2
storage over Li‐N‐H, Li‐Mg‐N‐H and Li‐
Ca‐N‐H systems has been demonstrated.
PREMIUM PUBLICATIONS•
P
Chen,
ZT
Xiong,
LF
Yang,
GT
Wu
and
WF
Luo,
Mechanistic
Investigations
on
the
Heterogeneous
Solid‐State
Reaction of Magnesium Amides and Lithium Hydrides, J. Phys. Chem. B, published online (2006)•
JJ Hu, GT Wu, YF Liu, ZT Xinog, P Chen, K Murata, K Sakata and G Wolf, Hydrogen
Release from
Mg(NH2
)2
‐MgH2
through Mechanochemical
Reaction. J. Phys. Chem. B, published online (2006)•
ZT
Xiong,
GT
Wu,
JJ
Hu
and
P
Chen,
Thermodynamic
and
kinetic
investigations
of
the
hydrogen
storage
in
the
Li‐
Mg‐N‐H system, J. Alloys Compd, 398, 235‐239 (2005)•
ZT Xiong, GT Wu, JJ Hu
and P Chen, Ternary imides for hydrogen storage. Adv. Mater., 16, 1522‐1524 (2004)•
P
Chen,
ZT
Xiong,
JZ
Luo,
JY
Lin
and
KL
Tan,
Interaction
between
Lithium
Amide
and
Lithium
Hydride.
J.
Phys.
Chem. Â B,
107, 10967‐10970 (2003)
88
Assoc Professor CHIN Wee ShongPostdoc., Univ. of Bristol, 1994; Ph.D., National Univ. of Singapore, 1993;
B.Sc., National Univ. of Singapore, 1987
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chinws.htm
Email: [email protected]
RESEARCH INTERESTSOur
research
focus
on
the
field
of
nanostructures
and
their
assemblies.
The
targets
include
finding
new
ways
to
synthesize
size‐
and
shape‐controllable
nanocrystals,
understanding
their
interactions and properties, and developing methods to assemble them into novel nanostructures.
Specific focuses are:• Nanostructural
materials and their assembly • Surface and spectroscopy
RECENT HIGHLIGHTReference: Angew. Chem. Int. Edn, 43, 5685 (2004)
An
unprecedented
preparation
of
Ag2
S
nanocrystals,
with
predictable
sizes
and
shapes,
using
chemical
method
starting
from
an
easily
prepared
silver
precursor
is
reported.
Through
a
careful
tuning
of
several
critical
thermodynamic
and
kinetic
parameters,
well‐defined
shapes
of
Ag2
S
nanocrystals,
from
nanocubes,
faceted
or
spherical nanocrystals,
to nanorods,
can
be
readily
produced.
PREMIUM PUBLICATIONS•
WP
Lim,
Z
Zhang,
HY
Low and
WS
Chin, A
Neat
Preparation
of
Ag2S
nanocrystals
with
Predictable
Shapes
and
Sizes, Angew. Chem. Int. Edn, 43, 5685 (2004) •
WP Lim, HY Low and WS Chin, IR‐luminescent PbS‐polystyrene Nanocomposites
Prepared from
Random
Ionomers
in Solution, J. Phys. Chem. B,
108, 13093 (2004) •
TP Ang, TSA Wee and WS Chin, Three‐dimensional self‐assembled monolayer (3D SAM) of n‐alkanethiols
on copper
nanoclusters,
J. Phys. Chem. B,
108, 11001 (2004) •
TP Ang
and WS Chin, Dodecanethiol‐protected Copper/Silver Bimetallic Nanoclusters
and Their Surface Properties, J.
Phys. Chem. B,
109, 22228
(2005) •
Z
Zhang,
SH
Lee,
JJ
Vittal
and
WS
Chin,
A
Simple
Way
To
Prepare
PbS
Nanocrystals
with
Morphology
Tuning
at
Room Temperature,
J. Phys. Chem. B, 110, 6649‐6654 (2006)
99
Assoc Professor CHUAH Gaik
KhuanPostdoc., Fritz‐Haber‐Instituet, Berlin , 1987; Ph.D., Texas A&M Univ., 1987;
B.Sc., Univ. of Singapore, 1984
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chuahgk.htm
Email: [email protected]
RESEARCH INTERESTSWe
study
the
synthesis
of
useful
materials
for
catalysis
including
modification
of
textural
properties
such
as
surface
area,
porosity,
thermal
stability
and
introduction
of
dopants
for
specific functionalities . Specific focuses are:• Synthesis of micro‐mesoporous
materials for catalysis • Catalysis in fine chemicals synthesis and renewables
RECENT HIGHLIGHTReference: Curr. Org. Chem., 10(13), 1639‐1654 (2006)
The
Meerwein‐Ponndorf‐Verley
(MPV)
transfer
hydrogenation
of
aldehydes
and
ketones
to
the
corresponding alcohols is distinguished by its exceptional chemoselectivity.
The
article
provides
a critical review of the recent literature on heterogeneous catalysts for the MPV reaction.
PREMIUM PUBLICATIONS•
GK
Chuah,
S
Jaenicke,
YZ
Zhu
and
SH
Liu,
Meerwein‐Ponndorf‐Verley
Reduction
over
Heterogeneous
Catalysts,
Curr. Org. Chem., 10(13), 1639‐1654 (2006)•
YT Nie, GK Chuah, and S Jaenicke, Domino‐cyclisation
and hydrogenation of citronellal to menthol over bifunctional
Ni/Zr‐Beta and Zr‐beta/Ni‐MCM‐41 catalysts, Chem. Commun., 790 –
792 (2006)•
SA Bagshaw, NI Baxter, DRM Brew, CF Hosie, YT Nie, S Jaenicke
and GK Chuah, Highly ordered mesoporous
MSU‐
SBEA
/zeolite
Beta composite material, J. Mater. Chem.
16, 2235 – 2244 (2006) •
YZ Zhu, GK Chuah
and S Jaenicke, Selective Meerwein‐Ponndorf‐Verley, Reduction of α,β‐Unsaturated Aldehydes
over Zr‐Zeolite
Beta, J. Catal., 241, 25‐33 (2006) •
YZ Zhu, KL Foo, GK Chuah
and S Jaenicke, Dynamic Kinetic Resolution of Secondary Alcohols Combining Enyzme‐
Catalyzed Transesterification
and Zeolite‐Catalyzed Racemization, Chem. Eur. J., in press
M
O
CH
R2
R1
R3 R4
C
M
O O
C
R4R3
C
HR2
R1
M
O O
C
R4R3
C
R2
R1H
1010
Asst Professor FAN Wai
YipPostdoc., Univ. of California Berkeley, 2000; Ph.D., Univ. of Cambridge, 1998;
M.Sc., Univ. of Toronto, 1996; B.Sc., Univ. of London, 1994
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/fanwy.htm
Email: [email protected]
RESEARCH INTERESTSMy
research
area
is
in
the
spectroscopy
and
photochemistry
of
reactive
intermediates
are
explored in systems ranging from atmospheric chemistry, organometallic
homogeneous catalysis
to nanomaterial
formation mechanism . Specific focuses are:• Reactive intermediate chemistry in homogeneous catalysis and gas phase systems • Light‐induced nanochemistry
PREMIUM PUBLICATIONS•
H Tan, SP Li and WY Fan, Core-shell and hollow nanocrystal
formation via small molecule surface photodissociation;
Ag@Ag2
Se as an example, J Phys Chem B, 110, 15812-15816 (2006) •
TS Chong,, S T Tan and W Y Fan, FTIR Studies of Iron Carbonyl Intermediates in Allylic
Alcohol Photoisomerization,
Chem. Eur
J, 12, 5128-5133 (2006) •
Tan, H, E YE and W Y Fan, Alumina-template synthesis of fluorescent RuO2
nanotubes
derived from Ru3
(CO)12
cluster.
Adv Materials, 18, 619-623 (2006) •
YE, E, H Tan, S P Li and W Y Fan, Self-Organization of Core-shell Palladium Spherical Aggregates induced by Laser
and Thermal Decomposition of Pd(PPh3
)4
, Angew Chemie, 45, 1120-1123 (2006) •
CH
Ng
and
W
Y
Fan,
Shape
evolution
of
Cu2
O
nanostructures
via
kinetic
and
thermodynamic
controlled
growth,
J
Phys Chem B ASAP article
(2006)
RECENT HIGHLIGHTReference: Chem. Eur
J, 12, 5128-5133 (2006)
Key
intermediates
especially
the
p‐allyl
HFe(CO)3
(C3
H4
OH)
species
in
the
laser‐induced
photoisomerization
of
allylic
alcohols
to
aldehydes
catalyzed
by
Fe3
(CO)12
or
Fe(CO)4
PPh3
have been detected using FTIR absorption spectroscopy. p-allyl
Fe intermediate
1111
Dr GOH Lai YoongD.Sc., Univ. of London, 1997; Ph.D., Univ. of London, 1967; B.Sc., Univ. of
Hong Kong, 1963
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/gohlyg.htm
Email: [email protected]
MAJOR RECOGNITION•
Royal Society Commonwealth Developing Countries Fellowship, Royal Society, UK, 1991 •
Grant award from Australian Department of Industry and Technology, Bilateral Science and
Technology Collaboration programme
for work on Manganese Chemistry, Tenable at Monash
University, 1993‐1994
RESEARCH INTERESTSOrganochromium
and organoruthenium
chemistry are among the interests. Specific focuses are:•
Organochromium
chemistry, with special reference to the homolytic
reactivity of CpCr(CO)3
. to a variety of substrates
•
Organoruthenium
chemistry, with special reference to species containing hexamethylbenzene,
Cp/Cp*, indenyl, trispyrazolylborate‐type, and thiolato
ligands
RECENT HIGHLIGHTReference: Chem. Commun.
WEB
(2006)
Reaction
of
1,2,4,6‐thiatriazinyls
(4
and
9)
with [CpCr(CO)3
]2
(3) yielded new complexes
with
either η1, 5,
or η2,
6,
coordination
across
S=N
bonds.
(Scheme
1)
The
novelty
in
these
reactions
is
the
suppression
of
oxidative
addition
by
employment
of
radical
coupling
under mild conditions. This strategy provides
an
alternative
to
the
recently
reported
use
of
β‐pyridyl
groups in the building of multi‐spin
magnetic
complexes
incorporating
C,N,S
radicals.
PREMIUM PUBLICATIONS•
RYC
Shin,
LY
Goh,
Pentamethylcyclopentadienyl
Ruthenium(III)
vs
Hexamethylbenzene
Ruthenium(II)
in
Sulfur‐
Centered Reactivity of Their Thioether‐Thiolate
and Allied Complexes,
Acc. Chem. Res., 39, 301‐313 (2006)•
LY
Goh, W
Chen
and
RCS
Wong,
Unprecedented
Cage‐Opening
of P4S3
Initiated
by
an
Organometallic
Radical:
Synthesis and Structure of [Cp4
Cr4
(CO)9
(P4
S3
)], Angew Chem., Int. Ed. Engl.,
32, 1728‐1729 (1993) •
LY Goh, Z Weng, WK Leong
and JJ Vittal, Organometallic‐initiated cleavage of the metal chelate
and thiazole
rings in
a cyclopentadienylchromium
Complex, J. Am. Chem. Soc., 124, 8804‐8805 (2002) •
SL
Kuan,
WK
Leong,
LY
Goh
and
RW
Webster,
Redox
Dependent
Isomerization
of
Organometallic
RuII/RuIII
Compounds Containing the Hydrotris(Methimazolyl)Borate
Ligand.
An
Electrochemical
Square
Scheme
Mechanism.
Organometallics,
24, 4639‐4648 (2005) •
HF
Lau,
VWL
Ng,
LL
Koh,
GK
Tan,
LY
Goh,
TL
Roemmele,
SD
Sonja
and
RT
Boeré,
Cyclopentadienylchromium
complexes of 1,2,3,5‐dithiadiazolyls: η2π
complexes of cyclic sulfur‐nitrogen compounds, Angew. Chem. Int. Ed.,
45,
4498‐4501 (2006)
CrOCCOCO
SN
N
NPh
Ph5
CrOC
OC
N
SN
N
CF3
6
CrOC COCO
23
R = Ph (4)
+
R = CF3 (9)
SN
NN
R
Ph2
1212
Professor GOH Suat
HongD.Sc., National Univ. of Singapore, 1993; Ph.D., Univ. of Akron,
1971; M.Sc.,
Univ. of Akron, 1966; B.Sc., Nanyang
Univ., 1964
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/gohsh.htm
Email: [email protected]
MAJOR RECOGNITION•
National Science Award, National Science and Technology Board, Singapore, 1997 •
Staff Achievement Award, National University of Singapore, 1998 •
Achievement Award, ASEAN Committee of Science and Technology, 1998 •
FACS Citation Award, Federation of Asian Chemical Societies, 2003
RESEARCH INTERESTSMy
interests
lie
on
polymer/materials
science
–
recent
research
focuses
on
the
development
of
high‐performance
polymer‐grafted
carbon
nanotube/polymer
nanocomposites
.
Specific
focuses
are:• Polymer/carbon nanotube
nanocomposites• Double‐C60
‐end‐capped polymeric materials
RECENT HIGHLIGHTReference: Macromolecules, 39, 4932‐4934 (2006)
The
tensile
strength
and
the
toughness
of
poly(n‐
butyl
methacrylate)
are
increased
by
240%
and
190%,
respectively,
upon
end‐capping
with
C60
.
Poly(vinyl
chloride)
is
strengthened
and
toughened by the incorporation of double‐C60
‐end‐
capped poly(n‐butyl methacrylate).
PREMIUM PUBLICATIONS•
M Wang, KP Pramoda
and SH Goh, Reinforcing and toughening of poly(vinyl
chloride) with double‐C60‐end‐capped
poly(n‐butyl methacrylate), Macromolecules, 39, 4932‐4934 (2006)•
M
Wang,
KP
Pramoda
and
SH
Goh,
Enhancement
of
interfacial
adhesion
and
dynamic
mechanical
properties
of
poly(methyl
methacrylate)/multiwalled
carbon
nanotube
composites
with
amine‐terminated
poly(ethylene
oxide),
Carbon, 44, 613‐617 (2006)•
X
Li,
KL
Liu,
J
Li,
PS
Tan,
LM
Chan,
CT
Lim
and
SH
Goh,
Synthesis,
characterization,
and
morphology
studies
of
biodegradable
amphiphilic
poly[(R)‐3‐hydroxybutyrate]‐alt‐poly(ethylene
glycol)
multiblock
copolymers,
Biomacromolecules, in press•
Y Liu, DC Wu, WD Zhang, X Jiang, CB He, TS Chung, SH Goh
and KW Leong, Polyethylenimine‐grafted multiwalled
carbon
nanotubes
for
secure
noncovalent
immobilization
and
efficient
delivery
of
DNA,
Angewandte
Chemie
International Edition, 44, 4782‐4785 (2005)•
DC Wu, Y Liu, CB He and SH Goh, Blue photoluminescence from hyperbranched
poly(amino
ester)s, Macromolecules
38, 9906‐9909 (2005)
0.0 0.6 1.2 1.80
4
8
12
16
Stre
ss (M
Pa)
Strain (mm/mm)
Stress-strain curves of PBMA (lower curve) and C60
-PBMA-C60
(upper curve)
1313
Assoc Professor Leslie J HARRISONPh.D., Univ. of Glasgow, 1983; B.Sc., Univ. of Glasgow, 1980
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/harrison.htm
Email: [email protected]
RESEARCH INTERESTSMy specific focuses are:• Organic chemistry• Natural products
RECENT HIGHLIGHTWe are interested in the isolation of natural products and determination of their structures using
mainly
1D
and
2D
nuclear
magnetic
resonance
techniques.
At
present,
we
are
concentrating
on
the
constituents
of
three
plant
families,
the
Guttiferae,
the
Hepaticae
and
the
Orchidaceae.
The
compounds obtained are subjected to biological testing.
PREMIUM PUBLICATIONS•
LHD Nguyen and LJ Harrison, Xanthones
and Triterpenoids
from the Bark of Garcinia
Vilersiana, Phytochemistry, 53,
111‐114 (2000)•
LHD Nguyen and LJ Harrison, Xanthones
and Triterpenoids
from the Bark of Garcinia
Vilersiana,
Phytochemistry, 53,
111‐114 (1999)•
R
Huang,
LJ
Harrison
and
KY
Sim,
A
Triterpenoid
with
a
Novel
Abeo‐dammarane
Skeleton
from
Dysoxylum
cauliflorum, Tetrahedron Lett., 40, 1607‐1610 (1999)•
YW Leong, LJ Harrison and AD Powell, Phenanthrene
and Other Aromatic Compounds from Bulbophyllum
vaginatum,
Phytochemistry,
50, 1237‐1241 (1999)•
YW Leong
and LJ Harrison, (20R,23E)‐Eupha‐8,23‐diene‐3,25‐diol from Tripetalum
cymosum,
Phytochemistry,
50, 849‐
857 (1999)
1414
Professor HOR Tzi
Sum AndyPostdoc., Yale Univ. , 1984; D.Phil., Univ. of Oxford, 1983; B.Sc.(Hons),
Imperial College of Science and Technology, 1979
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/hor.htm
Email: [email protected]
MAJOR RECOGNITION•
D.Sc., University of London, 1999•
ASEAN Achievement Award (Sciences), ASEAN Business Forum, 1994•
Member, International Advisory Board,
Chemistry: An Asian Journal, VCH/Wiley, 2006‐present•
Member, International Advisory Board, Inorganica
Chimica
Acta
(Elsevier), 2003‐present•
Wilsmour
Fellow, University of Melbourne, 2004•
Inorganic Foundation Professor & Frances Lion Memorial Lecturer,
University of Sydney, 2003•
Anthony Mason Fellow, University of New South Wales, 1999 •
Chair, 9th International Symposium for Chinese Organic Chemists & 6th International
Symposium for Chinese Inorganic Chemists, 2006
RESEARCH INTERESTSWe
use
our
synthetic
organometallic
chemistry
capabilities
to
design
new
catalysts,
functional
materials
and
molecular
imaging
systems.
In
catalysis,
we
focus
on
ethylene
oligomerization,
Suzuki
and
other
C‐C
cross‐coupling
reactions.
Our
materials
research
encompasses
supramolecular
assembly and heteromultinuclear
syntheses. Specific focuses are:• Homogeneous & Environmental Catalysis • Heterometallic
Syntheses & Applications
RECENT HIGHLIGHTReference: Organometallics
, 25, 1199‐1205 (2006)
Under
solventless
conditions,
benzothiazole
reacts
with
benzyl
bromide
to
give
near‐quantitative
yield
of
N‐
benzylbenzothiazolium
bromide
(A),
which
is
a
convenient
air‐stable heterocyclic carbene
precursor. Treatment of A
with
Pd(OAc)2
in
DMSO
gives
an
unprecedented
dinuclear
N,S‐
heterocyclic
carbene
complex,
[PdBr2
(NHC)]2
(illustration)
which is active towards Mizoroki‐Heck coupling reactions.
PREMIUM PUBLICATIONS•
SH
Chong,
LL
Koh,
W
Henderson
and
TSA
Hor,
Methylation
of
[Pt2
(μ‐SRμ‐SPPh3
)4
]:En
route
to
mixed
thiolato
bridged complexes, Chemistry: An Asian Journal, 1264‐272 (2006) •
Z
Weng,
S
Teo
and
TSA
Hor,
Isolation
and
structural
elucidation
of
a
Ni(0)‐Al(CH3
)3
bimetallic
complex
with
an
agostic
alpha‐C–H in a Bridging Methyl, Chem. Commun., 12,
1319‐1321 (2006)•
SK
Yen,
LL
Koh,
FE
Hahn,
HV
Huynh
and
TSA
Hor,
Convenient
entry
to
mono‐
and
dinuclear
palladium(II)benzothiazolin‐2‐ylidene
complexes
and
their
activities
towards
heck‐coupling,
Organometallics,
25,
5105-5112 (2006) •
Z
Weng,
S
Teo,
LL
Koh
and
TSA
Hor,
Ethylene
oligomerization
of
coordinatively
&
electronically
unsaturated
low‐
valent
nickel,
Angew. Chem. Int. Ed., 44, 7560‐7564 (2005) •
Z
Weng,
S
Teo
and
TSA
Hor,
Singapore
Patent
Application
200604713‐8,
Thermally
stable
chromium(III)
catalysts
supported by tridentate ligands
for ethylene tetramerization
to 1‐octene (2006)
1515
Asst Professor HUANG DejianPostdoc., Massachusetts Inst. Techn.o, 2001; Ph.D., Indiana Univ. Bloomington,
1999; M.Sc., Chinese Acad. of Sciences, 1990; B.Sc., Fujian
Teachers Univ., 1987
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/huangdj.htm
Email: [email protected]
RESEARCH INTERESTSMy
research
area
is
in
Naturally
occurring
flavonoids
and
their
metal
complexes
as
enzymatic
antioxidant
(SOD)
mimetics,
sensing
of
reactive
oxygen
species
in
food
and
biological
systems
using
fluorescent
quantum
dots,
antioxidants
in
traditional
Chinese
medicine
(TCM).
Specific
focuses are:• Reactive oxygen species and antioxidants in foods and TCM • Transition metal chemistry and catalysis
PREMIUM PUBLICATIONS•
KX Hay, VY Waisundara, M Timmins, B Ou, K Papalado, N McHale and D Huang, High-Throughput Quantitation
of
Peroxyl
Radical Scavenging Capacity in Bulk Oils. J.Agri. Food Chem., 54, 5299-5305 (2006)•
D Huang, B Ou
and L Ronald, Prior the Chemistry behind antioxidant assays, J. Agri. Food Chem., 53, 1841‐1856 (2005) •
B
Ou,
D
Huang,
M
Hampsch‐Woodill
and
JA
Flanagan, When
East
Meets
West:
the
relationship
between
yin/yang
and antioxidation/oxidation, FASEB J.
, 7(2), 127‐129 (2003)•
D Huang, KB Renkema
and KG Caulton, Cleavage of F-C(sp2) bonds by MHR(CO) (PtBu2
Me)2
(M = Os and Ru; R = H,
CH3
or Aryl): Product dependence on M and R, Polyhedron, 25, 459-468 (2006)•
D
Huang,
PR
Koren,
K
Folting,
ER
Davidson
and
KG
Caulton,
Facile
and
Reversible
Cleavage
of
C‐F
Bonds.
Contrasting Thermodynamic Selectivity for Ru‐CF2H vs
F‐Os=CFH, J. Am. Chem. Soc., 122(37), 8916‐8931 (2000)
RECENT HIGHLIGHTReference: Analytical Chemistry, 78, 3097-3103 (2006)
A
novel
approach
to
monitoring
of
mainstream
smoke
reactive
oxygen
species
(ROS)
has
been
developed and applied to the quantitation
of
smoke oxidants.
Dihydrorhodamine
6G
(DHR‐6G)
was selected as the molecular probe and the reaction is monitoring in real time using a fiber optic
reflective fluorescent spectrometer.
1616
Dr HUYNH Hanh
VinhPh.D., Univ. Münster
(WWU), Germany, 2002; B.Sc., Univ. Münster
(WWU), Germany, 1999
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/huynh.htm
Email: [email protected]
MAJOR RECOGNITION•
Feodor
Lynen
Research Fellowship, Alexander von Humboldt Foundation, 2003‐2004
RESEARCH INTERESTSWe study organometallic
chemistry and catalysis. Specific focuses are:•
Synthesis of novel N‐heterocyclic Carbene
(NHC) complexes and their application as catalysts
for organic transformations •
Bioactivities of organometallic
compounds
RECENT HIGHLIGHTReference: Chem. Commun., 3833‐3835 (2006)
The truely
hemilabile
nature of a novel thioether‐functionalized N‐heterocyclic carbene
ligand
is
demonstrated in a range of Pd(II) complexes.
PREMIUM PUBLICATIONS•
HV Huynh, C Holtgrewe, T Pape, LL Koh
and E Hahn, Organometallics, 25, 245‐249 (2006) •
HV Huynh, TC Neo and GK Tan, Organometallics, 25, 1298‐1302 (2006)•
HV Huynh, N Meier, T Pape and FE Hahn, Organometallics, 25, 3012‐3018 (2006)•
HV Huynh, Y Han, J H H Ho and GK Tan, Organometallics,
25, 3267‐3274 (2006) •
SK Yen, LL Koh, FE Hahn, HV Huynh and TSA Hor, Organometallics, 25, 5105‐5112 (2006)
1717
Assoc Professor Stephan JAENICKEPostdoc., Max Planck Society, 1988; Postdoc., Michigan State University, 1983;
Ph.D., Dr. rer. nat., 1981; B.Sc., Diplomchemiker, 1976
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/jaenicke.htm
Email: [email protected]
RESEARCH INTERESTSWe study the heterogeneous catalysis with special emphasis on chiral
synthesis: hydrogenations
on
chirally
modified
solid
surfaces,
homogeneous
catalysts
immobilized
in
supported
ionic
liquids,
immobilized
enzymes,
whole
cell
fermentation
(white
biotechnology).
Specific
focuses
are:• Catalytic hydrogenation and hydroformylation; selective oxidations with molecular oxygen • Micro‐reactor applications in three‐phase flow: mass transport enhancement in Taylor flow
conditions
RECENT HIGHLIGHTReference: Chem. Eur. J. (to be cited as DOI: 10.1002/chem.200600723)
Kinetic
resolution
of
racemic
alcohols
by
enzymatic
transesterification
is
combined
with
racemization
of the off‐enantiomer
over a modified zeolite
catalyst. The bulky esters (octanoates
or
laurates)
formed
in
the
enzymatic
reaction
cannot
access
the
active
site
in
the
zeolite,
where
they could undergo undesired racemization, and are obtained with excellent enantiomeric
excess.
PREMIUM PUBLICATIONS•
YZ
Zhu,
GK
Chuah
and
S
Jaenicke,
Selective
Meerwein–Ponndorf–Verley
reduction
of α,β‐unsaturated
aldehydes
over Zr‐zeolite
beta, J. Catalysis, 241, 25‐33 (2006)•
S Jaenicke, Characterization of Heterogeneous Catalysts by
Use of
Model
Reactions,
Catalysis
Surveys
from
Asia,
9,
173‐185 (2005)•
N
Qafisheh,
S
Mukhopahdyay,
AV
Joshi,
Y
Sasson,
GK
Chuah
and
S
Jaenicke,
Potassium
Phosphate
as
a
High
Performance Solid Base in Phase Transfer Catalyzed Alkylation
Reactions, Ind. Eng. Chem Res., in press (2006) •
X Wang, JLC Lee, Y Nie
and S Jaenicke, Evaluation of multiphase microreactors
for the direct formation of hydrogen
peroxide,
Applied Catalysis A: General, in press (2006)•
YZ Zhu, KL Foo, GK Chuah
and S Jaenicke, Dynamic Kinetic Resolution of Secondary Alcohols Combining Enyzme‐
Catalyzed Transesterification
and Zeolite‐Catalyzed Racemization, Chem. Eur. J.,
in press (2006)
OH
OO
O
O(R )-1 -phenyle thanol
(S )-1 -phenyle thanol(inside m icrochannels o f zeo lite beta )
Acyl donor
racem iza tion ca talyst
L ipase
1818
Assoc Professor KANG Hway
ChuanPh.D., Caltech, 1989; B.Sc., Yale Univ., 1983
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/kanghc.htm
Email: [email protected]
RESEARCH INTERESTSMy specific
focuses include:• Computational chemistry
RECENT HIGHLIGHTMy research focuses upon the use of simulations grounded in statistical and quantum mechanics
to
provide
molecular
scale ʺpicturesʺ
of
physical
and
chemical
processes
in
molecules,
clusters,
surfaces and bulk materials. We are interested in modelling
the kinetics of catalytic reactions, the
structure
and
properties
of
solid
and
cluster
surfaces,
reaction
energetics,
the
interactions
and
reactions of molecules adsorbed on surfaces, and the energetics
of defects on surfaces and in the
bulk.
PREMIUM PUBLICATIONS•
HC Kang, Lateral Interactions Between Adsorbed Hydrogen Atoms on the Si(100)‐(2 x 1) Surface, Surf. Sci., 445, 167‐
176 (2000)•
ZH
Loh
and
HC
Kang,
Chemisorption
of
NH3
on
Si(100)‐(2x1):
A
Study
by
First‐Principles
Ab
Initio
and
Density
Functional Theory, J. Chem. Phys., 112, 2444‐2451 (2000)•
C Yang and HC Kang, Geometry of Dimer
Reconstruction on the C(100), Si(100), and Ge(100) Surfaces, J. Chem. Phys.,
110, 11029‐11037 (1999)•
C Yang and HC Kang, Cluster Study of the Dimer
Geometry on the C(100) Surface, Surf. Science,
409, 521 (1998)•
HC
Kang,
Spin
Polarization
and
the
Energetics
of
Chlorine
Adsorption
on
the
GaAs(110),
J.
Chem.
Phys.,
109,
6911‐
6915 (1998)
1919
Assoc Professor Stefan KASAPISPostdoc., Cranfield
Univ., 1993; Ph.D., Cranfield
Univ., 1991; M.Sc., Univ. of
London, 1988; B.Sc., Aristotle Univ., 1986
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/sk.htm
Email: [email protected]
MAJOR RECOGNITION•
Editor, Food Hydrocolloids, 2006‐present •
Member of the Editorial Board, Carbohydrate Polymerism, 2005‐present •
Organizer, 9th International Hydrocolloids Conference, 2008
RESEARCH INTERESTSGeneral
research
interest
lies
on
Structure‐function
relationships
in
hydrocolloids.
Specific
focuses are:• Gelatin, fat, sugar replacing in food products for improved sensory perception and health • Glass transitions and the kinetics of active compound release in foods and pharmaceuticals
RECENT HIGHLIGHTReference: Biomacromolecules, 7, 1671‐1678 (2006)
The
prevalent
analytical
framework
traditionally
employed
to
follow
the
transition
from
the
rubbery
to
glasslike
consistency
in
biomaterials
is
that
of
the
free
volume
theory
in
conjunction
with the WLF equation. Increasingly, the combined WLF/free volume approach is challenged by
the coupling model which is able to provide additional insights into the physics of intermolecular
interactions in synthetic materials at the vicinity of Tg. The model in the form of the Kohlrausch‐
Williams‐Watts
function
described
well
the
spectral
shape
of
the
local
segmental
motions
of
gelatin/co‐solute
at
Tg.
The
analysis
provided
the
intermolecular
interaction
constant
and
apparent
relaxation
time, parameters which
depend
on
chemical
structure.
Results
appear
to
be
encouraging for further explorations of the dynamics of densely packed biomaterials at the glass
transition region.
PREMIUM PUBLICATIONS•
S
Kasapis,
Building
on
the
WLF
/
free
volume
framework:
Utilisation
of
the
coupling
model
in
the
relaxation
dynamics of the gelatin / co‐solute system, Biomacromolecules, 7, 1671‐1678 (2006) •
SL Tay, S Kasapis, CO Perera
and PJ Barlow, Functional and structural properties of 2S soy protein in relation to other
molecular protein fractions, Journal of Agricultural and Food Chemistry, 54, 6046‐6053 (2006) •
IM
Al‐Marhoobi
and
S
Kasapis,
Further
evidence
of
the
changing
nature
of
biopolymer
networks
in
the
presence
of
sugar, Carbohydrate Research, 340, 771‐774 (2005) •
S
Kasapis
and
IM
Al‐Marhoobi,
Bridging
the
divide
between
the
high‐
and
low‐solid
analyses
in
the
gelatin
/
k‐
carrageenan
mixture, Biomacromolecules,
6, 14‐23 (2005) •
S Kasapis, Definition of a
mechanical
glass
transition
temperature for dehydrated foods, Journal
of
Agricultural
and
Food Chemistry, 52, 2262‐2268 (2004)
2020
Assoc Professor KHOO Soo
BengPostdoc., University of Utah, 1984; Ph.D., University of Alberta, 1984;
B.Sc.
(Hons), Universiti Sains Malaysia, 1978
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/khoosb.htm
Email: [email protected]
RESEARCH INTERESTSMy
specific focuses are:• Electrochemistry and electroanalytical
chemistry • Chemically modified electrodes
RECENT HIGHLIGHTReference: Chem. Commun., 640‐642 (2005)
Super‐hydrophilicity
was
first
generated
purely
by
electrochemical
means
(in
the
absence
of
uv
illumination source) at the surface of a In2
O3
‐SnO2
electrode. This is achieved by the application
of high anodic potentials for a prolonged period. Such
surfaces
are
reversibly
converted back
to
their original hydrophobic state on storage (in air or in water).
PREMIUM PUBLICATIONS•
J Premkumar, SB Khoo, Chemical Communications, 640‐642 (2005)•
B Yu, SB Khoo, Electrochemistry Communications, 4, 737‐742 (2002)•
SB Khoo, F Chen, Analytical Chemistry, 74, 5734‐5741 (2002)•
MR Khan, S. Khoo, Analytical Chemistry,
68, 3290‐3294 (1996)•
Q Cai, SB Khoo, Analytical Chemistry, 66, 4543‐4550 (1994)
2121
Assoc Professor KHOR EugenePh.D., Virginia Tech, 1983; B.Sc., Lakehead
Univ., 1979
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/khore.htm
Email: [email protected]
MAJOR RECOGNITION•
Associate Editor, Biomaterials, 2005•
International Committee, 7th Asia Pacific Chitin Chitosan
Symposium, 2006
RESEARCH INTERESTSGeneral research interest lies on chitin and chitosan
for biomedical applications. Specific focuses
are:• Developing bone cement • Developing anticoagulant
RECENT HIGHLIGHTReference: Biomacromolecules, 6, 80‐87 (2005)
A
methodology
was
developed
to
produce
chitin
derivatives
under
homogeneous
conditions.
This
has
widespread
implications
for
producing
a
myriad
of
chitin
derivatives
for
various
applications.
PREMIUM PUBLICATIONS•
Y
Zou
and
E
Khor,
Preparation
of
C‐6
Substituted
Chitin
Derivatives
under
Homogeneous
Conditions,
Biomacromolecules, 6, 80‐87 (2005)•
Z
Ge,
A‐S
Baguenard,
LY
Lim,
A
Wee
and
E
Khor,
Hydroxyapatite‐Chitin
Materials
as
Potential
Tissue
Engineered
Bone Substitutes,
Biomaterials, Britain, 25, 1049‐1058 (2004)•
E Khor
and LY Lim, Implantable Applications of Chitin and Chitosan, Biomaterials, Britain, 24 (13), 2339‐2349 (2003)
{Invited review}
2222
Assoc Professor LAI Yee HingPostdoc., Univ. of California at Berkeley and Lawrence Berkeley Laboratory,
1982; Ph.D., Univ. of Victoria, 1980; B.Sc., Nanyang
Univ. , 1978
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/laiyh.htm
Email: [email protected]
RESEARCH INTERESTSMy
specific focuses include:• Organic chemistry
RECENT HIGHLIGHTOur
research
interests
are
centred
mainly
on
the
studies
of
conjugated
aromatic
systems
going
from theoretically interesting molecules to organic materials for specific applications. A separate
effort focuses on the investigation of selected Chinese medicinal plants.
PREMIUM PUBLICATIONS•
Y Cao, KS Yong, ZQ Wang, WS Chin, YH Lai, JF Deng and GQ Xu, Dry Thienylation
of the Silicon (111)‐(7 X 7) Surface,
J. Am. Chem. Soc., 122, 1812‐1813 (2000)•
W Huang, H Meng, W‐L Yu, J Pei, ZK Chen and Y‐H Lai, A Novel Series Of p‐n
Diblock
Light‐Emitting Copolymers
Based On Oligothiophenes
And 1,4‐Bis(Oxadiazolyl)‐2,5‐Dialkyloxybenzene, Macromolecules, 32, 118‐126 (1999)•
Y Cao, XM Wei, WS Chin, Y‐H Lai, JF Deng, SL Bernasek
and GQ Xu, of Di‐Sigma
Bond in Benzene Chemisorption
on
Si(111)‐7x7
, J. Phys. Chem. B, 103, 5698‐5702 (1999)•
HK
Yap,
XJ
Zuo,
M
Toyoda,
Y
Okada,
SG
Ang,
Y‐H
Lai,
JM
Matloff,
A
Marchevsky,
VS
Ramgolam
and
SC
Jordan,
Immunosuppressive Effect of the Hydrophobic Extract of a Chinese
Herb On Rat Lung Allograft Rejection, Transplant.
Proc., 30, 980‐981 (1998)
2323
Asst Professor LAM YulinB.Sc.(Hons), National Univ. of Singapore, 1987; Ph.D., National Univ. of
Singapore, 1992; Research Fellow, The Scripps Research Inst., 1992‐1994;
Research Fellow, Inst. of Molecular and Cell Biology,
1994‐1996
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lamyl.htm
Email: [email protected]
RESEARCH INTERESTSMy
interests
are
as
follows
(i)
Devising
new
synthetic
strategies
for
traceless
combinatorial
synthesis; (ii) synthesizing and screening libraries of compounds to search for biological activities;
and (iii) developing polymer‐bound reagents and catalysts. My
specific focuses include:• Traceless Solid‐phase Synthesis of Heterocycles
and Their Biological Evaluations as Anticonvulsants, DHFR Inhibitors, Human Multidrug
Resistance Protein 4 Inhibitors and Anti‐Hepatitis B Agents
• Polymer‐supported Reagents and Catalysts
RECENT HIGHLIGHTReference: Org. Lett., 8, 3283‐3285 (2006)
A
methodology
was
developed
to
produce
chitin
derivatives.
An
efficient
and
regioselective
procedure
for
the
synthesis
of
1,2,3‐triazoles
via
a
[3+2]
cycloaddition
of
polymer‐bound
vinyl
sulfone
and
sodium
azide
is
described.
Microwave
irradiation
provided
significant
rate
enhancement
in
all
steps
of
the
3‐steps
protocol.
A
representative
set
of
23
compounds
was
prepared.
PREMIUM PUBLICATIONS•
T M C Tan, Y Chen, K H Kong, J Bai, Y Li, S G Lim, T H Ang and Y L Lam, Synthesis and the Biological Evaluation of
2‐Benzenesulfonylmethyl‐5‐Substituted‐Sulfanyl‐[1,3,4]‐Oxadiazoles
as
Potential
Anti‐Hepatitis
B
Virus
Agents,
Antiviral Res., 71, 7‐14 (2006)•
Y Gao
and Y L Lam, [3+2] Cycloaddition
Reactions in the Solid‐phase Synthesis of 1,2,3‐Triazoles, Org. Lett., 8, 3283‐
3285 (2006) •
C
H
Soh, W
K
Chui,
Y
L
Lam,
Efficient
Synthesis
of
2,4‐Disubsituted‐5‐Aminoimidazoles
Using
Microwave
Irradiation, J. Comb. Chem., 8, 464‐468 (2006) •
H Fu and Y L Lam, Traceless Solid‐Phase Synthesis of N1, N7‐Disubstituted Purines, J. Comb. Chem., 7, 734‐738 (2005) •
K
H
Kong,
Y
Chen,
X
Ma,
W
K
Chui
and
Y
L
Lam,
Traceless
Solid‐phase
Synthesis
of
Nitrogen‐containing
Heterocycles
and Their Biological Evaluations as Inhibitors of Neuronal Sodium Channels, J. Comb. Chem., 6, 928‐933
(2004)
Na+
SO
O- R1CH2X, 60oC or 100oC, DMF
R2CHO, piperidine orpiperidium acetate, THF or DMF, MW, 82oC or 111oC, 20min
NN
NNaN3, R3X, DIEA
SO O
R1
SO O
R1
R2R1 R2
MW,120oC, 20min
MW, 20min
R3
2424
Asst Professor Martin J LEARPostdoc., Tohoku Univ., 2000; Postdoc., Parke‐Davis & CNRS, 1997; Ph.D.,
Univ. of Glasgow, 1995; B.Sc., Univ. of Glasgow, 1991
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lear.htm
Email: [email protected]
RESEARCH INTERESTSMy
research
area
is
in
the
total
and
analogue
synthesis
of
natural
products
of
high
biological
relevance and structural complexity . Specific focuses are:• Total synthesis of natural antimalarial
(e.g.
bielschowskysin) and antibiotic (e.g.
platensimycin) leads
• Development of radiopharmaceuticals and peptide‐conjugate probes for disease detection and treatment
PREMIUM PUBLICATIONS•
Y
Koyama,
MJ
Lear,
F
Yoshimura,
I
Ohashi,
T
Mashimo
and
M
Hirama,
Efficient
Construction
of
the
Kedarcidin
Chromophore
Ansamacrolide, Org. Lett., 7, 267‐270 (2005)•
T Usuki, T Mita, MJ Lear, P Das, K Akiyama, F Yoshimura, M Inoue, S Tero‐Kubota and M. Hirama, Spin‐Trapping of
13C‐Labeled
p‐Benzynes,
Generated
by
Masamune‐Bergman
Cyclization
of
Bicyclic
Nine‐Membered
Enediynes,
Angew. Chem., Int. Ed., 43 (6), 5249‐5253 (2004)•
P
Das,
T
Mita,
MJ
Lear
and
M
Hirama,
Synthesis
of
13C‐labelled,
Bicyclic
Mimetics
of
Natural
Enediynes,
Chem.
Commun., 2624‐2625 (2002)•
S Kobayashi, S
Ashizawa, Y Takahashi,
Y
Suigura,
M Nagaoka,
MJ Lear and
M
Hirama, The
First Total
Synthesis of
N1999‐A2: Absolute Stereochemistry and Stereochemical
Implications into DNA Cleavage, J. Am. Chem. Soc., 123 (45),
11294‐11295 (2001) •
MJ
Lear,
F
Yoshimura
and
M
Hirama,
A
Direct
and
Efficient
a‐Selective
Glycosylation
Protocol
for
the
Kedarcidin
Sugar, L‐Mycarose: AgPF6
as a Remarkable Activator of 2‐deoxythioglycosides, Angew. Chem., Int. Ed., 40
(5), 946‐949
(2001)
RECENT HIGHLIGHTReference: Ongoing work
@ http://staff.science.nus.edu.sg/~chmlmj/
Total
synthesis,
methodological
and
bioimaging
programmes
are
being
combined
in
order
to
develop new antimalarial, antibiotic, immunogenic, and biomedical agents and strategies.
2525
Dr Adrian M LEESingapore Millennium Found‐ation
Fellow, National Univ.. of Singapore, 2002‐
2004; Postdoc., Univ. of Cambridge, 2002; Ph.D., Univ. of Cambridge, 1997;
M.A., Univ. of Cambridge, 1996; B.A., Univ. of Cambridge, 1992
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/aml.htm
Email: [email protected]
MAJOR RECOGNITION•
NASA Achievement Award, NASA, 1996
RESEARCH INTERESTSSpecific focuses are:• Assessment of the environmental impact and economic cost of the present behaviour
and the future evolution of tropospheric
ozone and other greenhouse gases• Development and application of fragment‐based methods to accurately describe the properties
and interactions of very large molecules, such as nucleic acids and proteins
RECENT HIGHLIGHTReference: J. Phys. Chem. A,
110, 8777–8785, (2006)
This
study
describes
an
algorithm
for
fragmenting
a
molecule
with
a
well‐defined
Kekulé
or
valence‐bond
structure
into
a
significant
number
of
smaller
fragment
molecules
that
are
more
amenable
to
high
level
quantum
chemical
calculations.
By
taking
an
appropriate
linear
combination of the fragment energies the study shows that it is possible in many cases to obtain
highly accurate total energies when compared to the total energy
of the full molecule. Using the
method described in this work it is in principle possible to obtain very accurate total energies of
systems
containing
hundreds,
if
not,
thousands
of
atoms
as
the
approach
is
subject
to
massive
parallelization
.
PREMIUM PUBLICATIONS•
RPA Bettens and
AM Lee,
A new algorithm
for
molecular
fragmentation
in
quantum
chemical
calculations,
J.
Phys.
Chem. A, 110, 8777–8785 (2006)•
AM
Lee,
RL
Jones,
I
Kilbane‐Dawe
and
JA
Pyle,
Diagnosing
ozone
loss
in
the
extratropical
lower
stratosphere,
J.
Geophys. Res., 107,
doi:10.1029/2001JD000538 (2002)•
AM
Lee,
HK
Roscoe,
AE
Jones,
PH
Haynes,
EF
Shuckburgh,
MW
Morrey
and
HC
Pumphrey,
The
impact
of
the
mixing properties within the Antarctic stratospheric vortex on springtime ozone loss, J. Geophys. Res., 106,
3203–3211
(2001)•
HK
Roscoe,
AE
Jones
and
AM
Lee,
Midwinter
start
to
Antarctic
ozone
depletion:
Evidence
from
observations
and
models, Science, 278,
93–96 (1997)•
DJ
Wales and AM Lee, Structure and rearrangements of small trapped‐ion clusters, Phys. Rev. A, 47,
380–393 (1993)
Level-3 fragmentation of cis-3-hexanal presented in the form of an isodesmic
reaction, highlighting the underlying assumption of the method that ∆r
E = 0.
2626
Professor LEE Hian KeePh.D., Univ. of Canterbury, New Zealand, 1982; B.Sc., Univ. of Canterbury,
New Zealand, 1978
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/leehk.htm
Email: [email protected]
MAJOR RECOGNITION•
Editor, Analytica
Chimica
Acta, 2005 •
Member, Editorial Board, Journal of Chromatography A, 2004 •
Member, International Advisory Board, The Analyst, 1997 •
Member, Advisory Board, Analytical Sciences, 2004•
Member, Editorial Advisory Board, LCGC Asia Pacific, 2006•
Outstanding Researcher Award, NUS, 2006
RESEARCH INTERESTSMy
major
interest
is
focused
on
the
development
and
applications
of
solvent‐minimized,
miniaturized
extraction
techniques,
particularly,
but
not
limited
to,
aqueous
environmental
matrixes. Specific focuses are:• Separation science; microextraction• Environmental analysis
RECENT HIGHLIGHTReference: Anal. Chem., 78, 2853‐2858 (2006)
In
this
work, multiwalled
carbon
nanotubes
were
held
within
a
polypropylene
membrane
envelope
(2
cm
x
1.5
cm)
and
used
as
adsorbent
for
the
extraction
organophosphorus
pesticides
from
sewage
sludge.
PREMIUM PUBLICATIONS•
G Shen and HK Lee, Hollow fiber‐protected liquid‐phase microextraction
of triazine
herbicides, Anal. Chem.,
74, 648‐
654 (2002) •
Y He and HK Lee, Large‐volume sample stacking in acidic buffer for analysis of small organic and inorganic anions by
capillary electrophoresis, Anal. Chem., 71, 995‐1001 (1999) •
Y
Wang,
YC
Kwok,
Y
He
and
HK
Lee,
Application
of
dynamic
liquid‐phase
microextraction
to
the
analysis
of
chlorobenzenes
in water using a conventional microsyringe, Anal. Chem.,
70, 4610‐4614 (1998) •
W
Li
and
HK
Lee,
Use
of
triethylenetetraminehexaacetic
acid
combined
with
field‐amplified
sample
injection
in
speciation analysis by capillary electrophoresis, Anal. Chem., 70, 2666‐2675 (1998) •
Y He and HK Lee, Liquid‐phase microextraction
in a single drop of organic solvent using a conventional syringe, Anal.
Chem.,
69, 4634‐4640 (1997)
(b)
(a) Sample vial µ-SPE
Stir bar
C18 enclosed within HFM sheet (heat-sealed at open edges after folding)
Magnetic Stirrer
2727
Dr LEONG Lai PengPh.D., Univ. of Leeds, 2000; M.Sc., Univ. of Leeds, 1996; B.Sc., Universiti
Kebangsaan
Malaysia, 1995
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/leonglp.htm
Email: [email protected]
RESEARCH INTERESTSMain
interest
is
in
the
kinetics
of
chemical
reactions
especially
with
respect
to
bioactive
compounds
such
as
antioxidants
found
in
plants,
as
well
as
the
Maillard
reaction
in
foods
and
model systems. Specific focuses are:• Kinetics of antioxidant and free radical• Kinetic of Maillard
reaction
RECENT HIGHLIGHTReference: Food Chemistry, 99 (4), 775‐783 (2006)
The
paper
look
into
the
antioxidant
properties
of
aqueous
extracts
of
selected
plants
found
in
Singapore
market
and
their
potential
for
use
as
functional
food
ingredients. Antioxidants
from
these extracts can act synergistically to protect biomolecules
from being harmed
PREMIUM PUBLICATIONS•
G
Shui
and
LP
Leong,
Residue
from
start
fruit
as
valuable
source
for
functional
food
ingredients
and
antioxidant
nutraceuticals, Food Chemistry
, 97(2), 277‐284 (2006) •
Wong SP, LP Leong and JHW Koh, Antioxidant activities of aqueous
extracts of selected
plants, Food Chemistry, 99(4),
775‐783 (2006)•
V
Thavasi,
LP
Leong
and
RPA
Bettens,
Investigation
of
the
influence
of
hydroxy
groups
on
the
radical
scavenging
ability of polyphenols, J. Physical Chemistry A, 110, 4918‐4923 (2006)•
G
Shui
and
LP
Leong,
Rapid
screening
and
characterisation
of
antioxidants
of
Cosmos
caudatus
using
liquid
chromatography
coupled
with
mass
spectrometry,
J.
Chromatography
B‐analytical
Technologies
In
The
Biomedical
And Life Sciences, 827(1), 127‐138 (2005)•
G Shui, and LP Leong, Screening of identification of antioxidants in biological samples using high‐performance liquid
chromatogtaphy‐mass spectrometry and its application on Salacca
edulis
Reinw, J. Agricultural and Food Chemistry, 53,
880‐886 (2005)
A2H
A2 A1
A1H
R
RH
Regeneration of an antioxidant (A1H) by a second antioxidant (A2H) after scavenging radical R•:
2828
Assoc Professor LEONG Weng KeePh.D., Simon Fraser Univ., 1995; M.Sc., National Univ. of Singapore, 1992;
M.A., Cambridge Univ., 1986; Dip. Ed., National Inst. of Education, 1985;
B.A., Cambridge, 1982
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/leongwk.htm
Email: [email protected]
MAJOR RECOGNITION•
Visiting Professor, Kyoto University, 2006 •
Visiting Scientist, Cambridge University, 2005•
Visiting Scientist, ENSCP, 2002 and 2005•
Visiting Fellow, Tohoku University/JSPS, 2000
RESEARCH INTERESTSWe are interested in all aspects of organometallic
chemistry, ranging from synthesis to structure,
bonding,
reactivity
and
mechanistic
studies,
and
their
applications
in
catalysis
(homogeneous
and
heterogeneous),
nanomaterials
and
bioorganometallics.
We
are
interested
in
mononuclear,
dinuclear
as well as cluster compounds.
Specific focuses are:• Organometallic
chemistry ‐
synthesis, structure, bonding, reactivity, mechanisms, catalysis, materials
• Bioorganometallic
chemistry ‐
biopharmaceuticals, bioimaging, in vivo reactivity studies
RECENT HIGHLIGHTReference: J. Cluster Sci., 17, 111‐8 (2006)
The
synthesis
and
structural
characterization
of
two
novel
clusters,
Os6
(μ5
‐Sb)(μ‐H)2
(μ‐SbPh2
)(μ3
,η2‐
C6
H4
)(CO)17
and
Ru6
(μ5
‐Sb)(μ‐H)3
(CO)18
(SbPh3
)
are
presented. They are the first examples of osmium and
ruthenium clusters containing a naked μ5
‐Sb atom.
PREMIUM PUBLICATIONS•
VS Sridevi, WK Leong and Y Zhu, Catalytic Reductive Coupling of 9‐Bromofluorene, Organometallics, 25, 283‐8 (2006) •
PK
Chan,
WK
Leong,
KI
Krummel
and
MV
Garland,
Aminoethyl‐Functionalised
Cyclopentadienyl
Iridium
Complexes: Photochemical C‐H Activation and Carbonylation
of Cycloalkanes, Eur. J. Inorg. Chem., 1568‐72 (2006) •
SY
Ng,
GK
Tan,
LL
Koh,
LY
Goh,
WK
Leong,
S
Ye
and
Y
Zhu,
Heterobimetallic
Ruthenium‐Cobalt
Complexes
Containing the Pentamethylcyclopentadienyl
or Indenyl
Ligand, Eur. J. Inorg. Chem., 663‐70 (2006) •
KH
Chan,
WK
Leong
and
KHG
Mak,
Thermolysis
of
the
Osmium‐Antimony
Clusters
Os3
(CO)11
(SbMe2
Ar):
Higher
Nuclearity
Clusters and Arrested Orthometallation, Organometallics,
25, 250‐9 (2006) •
P
Srinivasan
and
WK
Leong,
Reaction
of
the
Heteronuclear
Cluster
Cp*IrRu3
(μ‐H)2
(CO)10
with
Alkynes:
Stereoselective
Binding, Eur. J. Inorg. Chem., 464‐72 (2006)
2929
Professor LI Fong Yau SamD.Sc., Imperial College, 1998; Ph.D., Imperial College, 1984; B.Sc., Imperial
College, 1981
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lifys.htm
Email: [email protected]
MAJOR RECOGNITION•
Outstanding Researcher Award, National University of Singapore/IMRE, 1999•
Dupont
Accomplishment Award, DuPont Company, 1993
RESEARCH INTERESTSAreas
of
research
interest
include
capillary
electrophoresis,
lab‐on‐chip
devices,
environmental
analysis,
biomedical
analysis,
bioimaging,
sensor
technologies,
lab‐on‐chip
devices,
nanomaterials
analysis,
chromatographic
techniques,
scanning
probe
microscopy,
supercritical
fluid extraction and chromatography. Specific focuses are:• Capillary electrophoresis• Environmental and biomedical analysis
RECENT HIGHLIGHTReference: Langmuir 18 (16): 6324‐6329 (2002)
We
developed
an
effective
generic
immobilization
platform
to
achieve
one‐step
direct
covalent
attachment
of
arrayed
proteins
with
good
reproducibility
and
uniformity.
We
also
show
that
the
approach
can
be
adapted
via
photolithography
to
produce
high‐density
protein
microarrays
for
simultaneous
parallel
biological assays.
PREMIUM PUBLICATIONS•
WS
Law,
P
Kuban,
LL
Yuan,
JH
Zhao,
SFY
Li,
and
PC
Hauser,
Determination
of
tobramycin
in
human
serum
by
capillary electrophoresis with contactless
conductivity detection, Electrophoresis, 27(10), 1932‐1938 (2006)•
LJ
Yu
and
SFY
Li,
Dynamic
pH
junction‐sweeping
capillary
electrophoresis
for
online
preconcentration
of
toxic
pyrrolizidine
alkaloids in Chinese herbal medicine, Electrophoresis, 26(22), 4360‐4367 (2005) •
WS
Law,
JH
Zhao
and
SFY
Li,
On‐line
sample
enrichment
for
the
determination
of
proteins
by
capillary
zone
electrophoresis with poly(vinyl
alcohol)‐coated bubble cell capillaries, Electrophoresis, 26(18), 3486‐3494 (2005)•
Y
Xu,
WD
Qin,
YH
Lau
and
SFY
Li,
Combination
of
cationic
surfactant‐assisted
solid‐phase
extraction
with
field‐
amplified sample stacking for highly sensitive analysis of chlorinated acid herbicides by capillary zone electrophoresis,
Electrophoresis, 26 (18), 3507‐3517 (2005)•
LJ Yu, Y Xu, HT Feng and SFY Li, Separation and determination of
toxic pyrrolizidine
alkaloids in traditional Chinese
herbal medicines by micellar
electrokinetic
chromatography with organic modifier, Electrophoresis, 26(17), 3397‐3404
(2005)
Scanning tunneling microscopy of surface morphology of human IgG
molecules on protein arrays produced by direct covalent attachment.
3030
Assoc Professor LI TianhuPostdoc., Scripps Research Institute, 1994; Ph.D., State Univ. of New York,
1992; M.Sc., Beijing Inst. of Chemical Technology, 1982; B.Sc., Jilin Univ.,
1980
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lth.htm
Email: [email protected]
RESEARCH INTERESTSMy specific focuses include:• Nuclear acid chemistry
RECENT HIGHLIGHTThe primary focus of my group in recent years has been directed toward the exploration of new
properties
of
G‐quadruplex
and
i‐motif
as
well
as
their
diagnostic
and
therapeutic
applications.
Several
circularly
unimolecular
and
bimolecular
G‐quadruplex
and
i‐motif
have
accordingly
been
made
in
our
lab
in
the
past
years
while
preparation
of
fluorescence‐tagged
circular
G‐
quadruplex
and
i‐motif
are
currently
in
progress.
We
hope
that
circular
G‐quadruplex
and
i‐
motif
could
be
useful
molecular
tools
for
interfering
certain
biological
functions
of
tetraplex‐
binding
proteins
and
for
examining
the
winding
and
resolving
mechanisms
of
G‐quadruplex
catalyzed by G‐quadruplex‐promoting and disintegrating proteins.
PREMIUM PUBLICATIONS•
D
Liu,
J
Chen,
AHF
Lee,
LMC
Chow,
ASC
Chan
and
TH
Li,
Small
Circular
Oligodeoxynucleotides
Achieved
from
Self‐Assembling Entities, Angew. Chem., Int. Ed. Engl., 42(7), 797‐799, (2003)•
AHF
Lee,
ASC
Chan and TH Li,
Synthesis
of
5‐(7‐hydroxyheptyl)‐1,2‐dithiolan‐3‐one
1‐oxide,
a
core
functionality
of
antibiotic leinamycin, Tetrahedron, 59, 833‐839, (2003)•
J
Qi,
T.
Li
and
ASC
Chan,
Fungicide
chinomethionate
as
a
new
family
of
photoinducible
DNA‐cleaving
agens,
Bioorganic & Medicinal Chemistry Letters, 13(20), 3561‐3563, (2003)•
AHF
Lee,
J
Chen,
D
Liu,
TYC
Leung,
ASC
Chan
and
TH
Li,
Acid‐Promoted
DNA‐Cleaving
Activities
and
Total
Synthesis of Varacin
C, Journal of the American Chemical Society, 124(47), 13972‐13973, (2002)•
AHF
Lee,
ASC
Chan
and
TH
Li,
Acid‐accelerated
DNA‐cleaving
activities
of
antitumor
antibiotic
varacin,
Chemical
Communications, 18,
2112‐2113, (2002)
3131
Asst Professor LIU XiaogangPostdoc., Massachusetts Inst of Tech, 2006; Ph.D., Northwestern Univ, 2004;
M.Sc., East Carolina Univ, 1999; B.Sc., Beijing Tech and Business Univ, 1996
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/liuxg.htm
Email: [email protected]
RESEARCH INTERESTSMy general interests are supramolecular
chemistry, materials science, and bioinorganic chemistry.
Specific focuses are:• Controlling assemblies of dynamically interacting biological molecules • Understanding of relations between structure and physical properties
PREMIUM PUBLICATIONS•
JM
Soon,
CW
Lim,
KP
Loh,
et
al,
Initial‐stage
oxidation
mechanism
of
Ge(100)2x1
dimers,
Phys. Rev. B.,
72, 115343 (2005) •
Liu,
S
Guo
and
CA
Mirkin,
Surface
and
Site‐Specific
Ring‐Opening
Metathesis
Polymerization
Initiated
by
Dip‐Pen
Nanolithography, Angew. Chem. Int. Ed. Engl., 42, 4785 (2003)•
J‐M Nam, MA Ratner, X Liu and CA Mirkin, Single‐Walled Carbon Nanotubes
and C60
Encapsulated by a
Molecular
Macrocycle, J. Phys. Chem. B., 107, 4705 (2003)•
X Liu, CL Stern and Mirkin, Chemical Origami: Formation of Flexible 52‐Membered Tetranuclear
Metallacycles
via a
Molecular Square Formed from a Hemilabile
Ligand, Organometallics, 21, 1017 (2002)•
M Su, X Liu, S‐Y Li, VP
Dravid
and CA
Mirkin,
Moving
Beyond
Molecules:
Patterning Solid‐State
Features via
Dip‐
Pen Nanolithograpy
with Sol‐Based Inks, J. Am. Chem. Soc., 124, 1560 (2002)
3232
Assoc Professor LOH Kian PingPostdoc., National Inst. for Material Science, Tsukuba, Japan, 1998; Ph.D.,
Oxford Univ., 1996; B.Sc., National Univ. of Singapore, 1994
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lohkp.htm
Email: [email protected]
MAJOR RECOGNITION•
Co‐chair of Engineering Conference International (ECI), ECI conference series, 2007•
Advisory Panel of Nanodiamond
and Nanocarbon
Conference, First Conference, Osaka, 2006•
Senior Adjunct scientist, Institute of Materials Research and Engineering, 2006‐07
RESEARCH INTERESTSSpecific focuses are:• Diamond Surface Science and Diamond Biosensors• Nanomaterials
and Self‐assembly of Molecular Films
RECENT HIGHLIGHTReference: J. Applied Physics, 99, 104309 (2006)
Chemisorption
of
atoms
on
the
single
walled
Boron
Nitride
nanotube
with
a
particular
chiral
pattern
can
produce
perturbations
which
are
coupled
to
the
band
gap
and
affect
the
electronic
polarization. The largest perturbation to electronic Hamiltonian
is produced by pairwise
H‐H or
H‐F chemisorption
on B‐N chains along the wrapping axis. This causes most significant lowering
of
tip
work
function,
and
induces
negative
electron
affinity
on
Boron‐tipped
end
of
the
Boron
Nitride Nanotube.
PREMIUM PUBLICATIONS•
JM
Soon,
CW
Lim,
KP
Loh,
et
al,
Initial‐stage
oxidation
mechanism
of
Ge(100)2x1
dimers,
Phys. Rev. B.,
72, 115343 (2005) •
HR
Gu, Su
X
and
KP
Loh,
Electrochemical
impedance
sensing
of
DNA
hybridization
on
conducting
polymer
film‐
modified diamond, J. Phys. Chem. B, 109, 13611‐13618 (2005 )•
W Chen, L Wang, C Huang, KP Loh and ATS Wee, Effect of functional group (fluorine) of aromatic thiols
on electron
transfer at the molecule‐metal interface
,
Journal of the American Chemical Society., 128, 935‐939 (2006)•
M
Lin,
JPY
Tan,
C
Boothroyd,
KP
Loh,
ES
Tok
and
YL
Foo,
Direct
observation
of
single‐walled
carbon
nanotube
growth at the atomistic scale, Nano
Letters,
6, 449‐452 (2006) •
T
Ouyang,
XY
Gao,
DC
Qi,
KP
Loh
et.
al.,
Cycloadditions
on
diamond(100)
2x1:
Observation
of
lowered
electron
affinity due to hydrocarbon adsorption, J. Phys. Chem. B, 110, 5611‐5620 (2006)
3333
Asst Professor LU YixinPostdoc., Nagoya Univ., 2001; Postdoc., Clinical Research Inst. of Montreal,
2000; Ph.D., McGill Univ., 2000; B.Sc., Fudan
Univ., 1991
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/luyx.htm
Email: [email protected]
RESEARCH INTERESTSWe
study
Asymmetric
organocatalysis/Green
Chemistry/Medicinal
Chemistry.
Specific
focuses
are:• Hydrophobic organocatalyst‐promoted asymmetric reactions in water• Development of analgesics, anti‐cancer agents and antibiotics
RECENT HIGHLIGHTReference: Chem. Commun., 2801 (2006)
The
natural
tryptophan
was
shown
to
be
able
to
catalyze
the
direct
aldol
reactions
between
various cyclic ketones
and aromatic aldehydes
in water with high enantioselectivity.
PREMIUM PUBLICATIONS•
Y Lu, TK Lum, YWA Leow, G Weltrowsak, TM‐D Nguyen, C Lemieux, NN Chung and PW Schiller, Replacement of
the N‐terminal Tyrosine
Residue
in Opioid
Peptides with 3‐(2,6‐
Dimethyl‐4‐carbamoylphenyl)propanoic Acid (Dcp)
Results in Novel Opioid
Antagonists,
J. Med. Chem.,
49, 5382 (2006)•
Z Jiang, Z Liang, X Wu and Y Lu, Asymmetric Aldol
Reactions Catalyzed by Tryptophan
in Water,
Chem. Commun.
2801 (2006)•
Y
Lu,
TM‐D
Nguyen,
G
Weltrowska,
I
Berezowska,
C
Lemieux,
NN
Chung
and
PW
Schiller,
[2ʹ,6ʹ‐
Dimethyltyrosine]Dynorphin
A(1‐11)‐NH2
Analogues
Lacking
an
N‐Terminal
Amino
Group:
Potent
and
Selective
Opioid
Antagonists, J. Med. Chem., 44, 3048 (2001)•
Y
Lu
and
G
Just,
Stereoselective
Synthesis
of
RP
‐
and
SP
‐
Dithymidine
Phosphorothioates
Using
Chiral
Indolo‐
oxazaphosphorine
Intermediates Derived from Tryptophan, Angew. Chem. Int. Ed., 39, 4521 (2000)•
M
Manoharan,
Y
Lu,
MD
Casper
and
G
Just,
Allyl
Group
as
a
Protecting
Group
for
Internucleotide
Phosphate
and
Thiophosphate
Linkages
in
Oligonucleotide
Synthesis:
Facile
Oxidation
and
Deprotection
Conditions,
Org.
Lett.,
2,
243‐246 (2000)
R2
O
R1 H
O
R
OH
R1
O
R2 R+ L-Tryptophan
H2O, RT
up to 96% ee
3434
Dr MAK Ka Wai KarenPostdoc., Hong Kong Univ. of Science and Tech., 2004; Ph.D., Hong Kong Univ.
of Science and Tech., 2003; B.Sc., Hong Kong Univ. of Science and Tech., 1999
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/mak.htm
Email: [email protected]
RESEARCH INTERESTSSpecific focuses are:• Enzyme sensors for environmental analysis • Substrate recycling in multienzyme
system
PREMIUM PUBLICATIONS•
KKW Mak, AWC Law, S Tokuda, H Yanase
and R Renneberg, Application of cyanide hydrolase
from Klebsiella
sp. in
biosensor system for detection of low‐level cyanide, Appl
Microbiol
Biotechnol
, 67, 631‐636 (2005) •
KKW Mak, H Yanase
and R Renneberg, Novel optical biotest
for determination of cyanide traces in marine fish using
microbial cyanide hydratase
and formate
dehydrogenase, Microchimica
Acta, 149, 131‐135 (2005) •
RCH
Kwan,
PYT
Hon,
KKW
Mak
and
R
Renneberg,
Amperometric
Determination
of
Lactate
with
Novel
Trienzyme/Poly(carbamyol) Sulfonate
Hydrogel‐based Sensor, Biosensors and Bioelectronics, 19, 1745‐1752 (2004) •
KKW
Mak,
U
Wollenberger,
F
Scheller
and
R
Renneberg,
An
amperometric
bi‐enzyme
sensor
for
determination
of
formate
using cofactor regeneration, Biosensors and Bioelectronics, 18, 1095‐1100 (2003) •
SCK Lau, KKW Mak, F Chen and P Qian, Bioactivity of bacterial strains isolated from marine biofilms
in Hong Kong
Waters for the induction of larval settlement in the marine polychaete
Hydroides
elegans, Mar Ecol Prog
Ser, 226: 301‐
310
(2002)
3535
Dr MAUNG MAUNG SawPh.D., National Univ. of Singapore, 2006; M.B.B.S., Inst, of Medicine (1),
Yangon, 1992
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/maung.htm
Email: [email protected]
MAJOR RECOGNITION•
National Consultant, Nuclear Medicine Section, Division of Human
Health, International
Atomic Energy Agency (IAEA), 2005‐06 •
Expert on Radiopharmacy, Nuclear Medicine Section, Division of Human Health,
International Atomic Energy Agency (IAEA), 2002‐06
RESEARCH INTERESTSMajor
interest
is
on
“Bioorganometallic
Chemistry”
with
emphasis
on
the
development
of
radiopharmaceuticals
and
probes
for
“molecular
imaging
and
therapy”
(from
bench‐top,
translational
medicine
to
clinical
trial).
There
is
minor
focus
on
organometallic‐based
drugs,
biosensors and nano‐devices for diagnosis and therapy.
Specific focuses are:• Bioorganometallic
Chemistry• Molecular Imaging and Therapy
RECENT HIGHLIGHTReference: doi:10.1016/j.ica.2006.04.023
The synthesis
and
characterization
of
new
fac‐{M(CO)3}+
(M
=
Tc, Re)
based
complexes
with
bi‐
and
tridentate
ligands
and
a
pendant
C18
chain
is
described.
Due
to
the
lipophilicity
of
the
complexes they are potential surrogates for Lipiodol, a liver cancer therapy agent. The complexes
are very stable which makes them suitable for application in radioimaging
and –therapy.
PREMIUM PUBLICATIONS•
MM S, P Kurz, N Agorastos, TSA Hor, FX Sundram, YK Yan and
R
Alberto, Complexes with
the
fac‐{M(CO)3
}+ (M = 99mTc, Re) moiety and long alkyl chain ligands
as Lipiodol
surrogates, Inorg. Chim. Acta, 359(12), 4087‐4094 (2006) •
FX Sundram,
TCM Chau,
P Onkhuudai, P Bernal
and AK Padhy, Eur. J. of Nucl. Med. & Mol. Imaging, 2(31), 250‐257
(2004) •
FX
Sundram,
SW
Yu,
JM
Jeong,
S
Somanesan,
J
Premaraj,
MM
Saw
and
B.S.
Tan,
Ann.
Acad.
Med.
Singapore,
30(5),
542‐5 (2001)
3636
Asst Professor David G POPOVICHPostdoc., NSERC, Vancouver 2005; Postdoc., Univ. of British Columbia, 2004;
Ph.D., Univ. of British Columbia, 2004; M.Sc., Univ. of Toronto, 1996; B.Sc.,
Univ. of Toronto, 1991
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/popovich.htm
Email: [email protected]
RESEARCH INTERESTSMy
specific focuses are:• Bioactive plant foods and extracts derived from natural health products and traditional food sources
• Dietary saponins
from ginseng (ginsenosides), bitter melon and soy)
RECENT HIGHLIGHTReference: Phytochemistry, 65, 337‐344 (2004)
Ginsenosides
Rh2 and Rg3 are rare bioactive
ginsenosides
and were effectively shown to be a
breakdown product of thermal extraction of
ginseng plant material, an underutilized resource,
and is potential source for natural health products
or pharmaceutical development
PREMIUM PUBLICATIONS•
DG Popovich and DD Kitts, Phytochemistry, 65, 337‐344 (2004)•
DG Popovich and DD Kitts, Arch.Biochem Biophys, 406, 1‐8 (2002)•
DG Popovich and DD Kitts, J. Biochem. Mol. Toxicol, 18(3), 143‐149, (2004)•
DG Popovich and DD Kitts, Can. J. Physiol. Pharmacol,
82, 183–190 (2004)•
DJ Jenkins,
DG
Popovich, CW Kendall, E Vidgen, N Tariq, TPP
Ransom,
TMS
Wolever,
V
Vuksan,
CC
Mehling,
DL
Boctor, C Bolognesi, J Huang and R Patten, Metabolism,
46(6), 1‐4 (1997)
3737
Dr SHIP Chee PingPostdoc., Ghent Univ., 2003; Ph.D, Univ. of Southampton, 2002; B.Sc.(Hons),
Univ. of Malaya, 1997
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/shipcp.htm
Email: [email protected]
RESEARCH INTERESTSGeneral interests include Heterogeneous Catalysis, Small Peptide Synthesis.
Specific focuses are:• Replacement of homogeneous liquid acids such as HF and H2
SO4
by heterogeneous solid acids• Cyclic dipeptides
PREMIUM PUBLICATIONS•
CP
Ship,
A
Zainudin
and YY Lim, Effects
of
aminocarboxylate
ligands
of
surface
active
copper(II)
complexes
on
the
hydrolysis of p‐Nitrophenyldiphenylphosphate,
J.Colloid
and
Interface Science, 217, 211 (1999)•
T
Campbell,
JM
Corker,
AD
Dent,
SA
EL‐Safty,
J
Evans,
SG
Fiddy,
MA
Newton,
CP
Ship
and
S
Turin,
Synthesis,
characterization and chemistry of transition metals in mesoporous
silica, Stud. Surf. Sci. Catal., 132, 667 (2001)
3838
Asst Professor SIM Wee SunPostdoc., Univ. of Cambridge, 1997; Ph.D., Univ. of Cambridge, 1996; B.Sc.
(Honours), National Univ. of Singapore, 1992
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/simws.htm
Email: [email protected]
MAJOR RECOGNITION•
DuPont Young Faculty Award, DuPont, 2001 •
SNAS Young Scientist Award, Singapore National Academy of Science/A*STAR, 2002
RESEARCH INTERESTSWe
aim
to
establish
viable
methods
of
functionalizing
surfaces
and
gaining
molecular‐level
understanding
and
control
of
chemical
transformations
occurring
at
the
interfaces
of
solid
materials used in catalysis, microelectronics and nanotechnology. Specific focuses are:• Surface Science and Catalysis• Thin Films and Nanomaterials
RECENT HIGHLIGHTReference: Langmuir, 22, 7861 (2006)
A
two‐step
surface
functionalization
approach
has
been
used
to
encase
Au
nanoparticles
in
monolayer
organometallic
Ru‐complex
shells
by
the
reaction
of
an
intermediate
surface‐bound
mercaptopropanoic
acid capping species with Ru
dodecacarbonyl
(Ru3
(CO)12
) clusters.
PREMIUM PUBLICATIONS•
WS
Sim
and
DA
King,
Surface‐Bound
Ketenylidene
(CCO)
from
Acetone
Decomposition
on
Ag{111}‐p(4
x
4)‐O,
Journal of the American Chemical Society, 117, 10583 (1995) •
WS
Sim,
P
Gardner
and
DA
King,
Surface‐Bound
Helical
Polyacetaldehyde
Chains
and
Bidentate
Acetate
Intermediates on Ag{111}, Journal of the American Chemical Society, 118, 9953 (1996) •
F Tao, WS Sim, GQ Xu and MH Qiao, Selective Binding of the Cyano
Group in Acrylonitrile
Adsorption on Si(100)‐2x1,
Journal of the American Chemical Society, 123, 9397 (2001) •
WS
Sim,
TC
Li,
PX
Yang
and
BS
Yeo,
Isolation
and
Identification
of
Surface‐Bound
Acetone
Enolate
on
Ni(111),
Journal of the American Chemical Society, 124, 4970 (2002) •
BS
Yeo,
ZH
Chen
and
WS
Sim,
Surface
Functionalization
of
Ni(111)
with
Acrylate
Monolayers,
Langmuir,
19,
2787
(2003)
Ru
Ru
Ru
CO
COCO
CO
CO
COOC
OC
CO
CO
OC CO
+Au
S
CO
O
S
C
OO
S
C
OO
SC
O
O
S CO
O
SC
O
O
S
COO
S
C O
O
S
COO
S
CO
SC
O
O S
COO Ru
Ru
COCO
CO
CO
Ru
Ru
CO
CO
COCO
Ru
Ru
COOC
OC
OC
Ru
Ru
OC
OC
OCCO H
OH
H
H
AuAu
S
C
OO
S
CO
O
S
CO O
SC
O
O
SC
O
O
SC
OO
S
CO
S
C OO
S
COO
S
CO
SC
O
OS
COO
O
O
H
H
H
HH
H
H
H
H
HH
H
3939
Asst Professor TAN Choon HongPostdoc., Harvard Univ., 2002; Ph.D., Univ. of Cambridge, 1999; B.Sc.
(Honours), National Univ. of Singapore, 1996
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/tanch.htm
Email: [email protected]
RESEARCH INTERESTSWe
are
interested
in
Bronsted
base
catalyzed
enantioselective
reactions.
We
are
particularly
interested
in
the
chiral
bicyclic
guanidines.
We
have
shown
that
they
can
catalyze
Michael
and
Diels‐Alder reactions with high enantioselectivities. Specific focuses are:• Chiral
bicyclic
guanidine catalyzed Michael and Diels‐Alder reactions• Enantioselective
Baylis‐Hilman
reaction
PREMIUM PUBLICATIONS•
W Ye, J Xu, CT Tan and C‐H Tan, 1,5,7‐Triazabicyclo[4.4.0]dec‐5‐ene (TBD) catalyzed
Michael reactions, Tetrahedron
Letters, 46, 6875‐6878 (2005)•
W
Ye,
D
Leow,
SLM
Goh,
CT
Tan,
CH
Chian
and
C‐H
Tan,
Chiral
bicyclic
guanidines:
a
concise
and
efficient
aziridine‐based synthesis, Tetrahedron Letters, 47, 1007‐1010 (2006)•
J
Xu,
Y
Guan,
S
Yang,
Y
Ng,
G
Peh,
C‐H
Tan,
Chiral
Imidazoline
Promoted
Asymmetric
Baylis‐Hillman
Reaction.
Chemistry ‐
An Asian Journal, In press•
J
Shen,
TT
Nguyen,
Y‐P
Goh,
W
Ye,
X
Fu,
J
Xu,
C‐H
Tan,
Chiral
Bicyclic
Guanidine
Catalyzed
Enantioselective
Reactions of Anthrones. Journal of the American Chemical Society, In press
RECENT HIGHLIGHTChiral
bicyclic
guanidine
was
found
to
be
an
excellent
catalyst
for
reactions
between
anthrones
and
various
dienophiles.
The
catalyst
can
tolerate
a
range
of
substituents
and
substitution
patterns on the anthrone. This is the first case of highly enantioselective
base catalyzed anthrone
Diels‐Alder reaction.
NO
OPh
Cl
OH
ClS
SNH
N
NBn BnO
Cl Cl
N
O
O
Ph
3iCH2Cl2, -20 oC, 4 hrs92% yield, 99% ee
(10 mol%)1
2c
+
4040
Asst Professor TOH Chee SengPostdoc., California Inst. of Technology, 2004; Ph.D., Univ. of Southampton,
2002; M.Sc., National Univ. of Singapore, 1995; B.Sc. (Hons), National Univ.
of Singapore, 1993
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/tohcs.htm
Email: [email protected]
RESEARCH INTERESTSOur
current
research
interests
are
in
nano‐scale
and
molecular
level
analyses
using
electrochemical methods whereby interfacing materials which interact directly with analytes
play
significant
roles. At
these
levels,
the
physico‐chemical
nature
of
elements
at
the
interface
functioning
as
signal
transducers
in
the
case
of
sensors
or
facilitating
selective
partition
in
the
case
of
chromatography
stationary
phases
will
become
increasingly
crucial
to
overall
performance of analytical techniques. Specific focuses are:• Using nanoporous
alumina as our ‘backbone’
for integrating biological molecules onto this physically nanostructured
and chemically inert system• Transport behaviours
of proteins and extend the same understanding to nanoscale
level separations of biomolecules
with the aim of achieving molecular level analysis
PREMIUM PUBLICATIONS•
GW Koh, S Agarwal and CS Toh, Development of a membrane‐based electrochemical immunosensor, submitted•
GW
Koh,
S
Agarwal,
PS
Cheow
and
CS
Toh,
Characterization
of
the
barrier
layer
of
nanoporous
alumina
films
prepared using two different contact configurations, Electrochim. Acta, in print•
CS
Toh,
An
Experiential
Research
Focused
Approach:
Implementation
in
a
Non‐Laboratory
Based
Graduate‐Level
Analytical Chemistry Course, J. Chem. Ed., in print•
L He and CS Toh, Recent Advances in Analytical Chemistry – A Material Approach, Anal. Chim. Acta, 556, 1–15 (2006) •
LY Liu and CS Toh, Chemical modification of nanoporous
alumina membranes, US patent pending, International PCT
Application No. PCT/SG2006/000183
RECENT HIGHLIGHTReference: Anal. Chim. Acta, 556, 1–15 (2006)
Advancements of materials research have profound direct impacts on developments in analytical
chemistry and may hold the key to improvement
of existing
or
new
techniques at
present
times
and
near
future.
This
work
reviews applications
of
materials in
analytical
chemistry,
with
focus
on
sensors,
separations
and
extraction
techniques.
A
broad
spectrum
of
materials
classified
as
hybrids,
nanomaterials
and
biomolecular
materials
were
surveyed
as
examples
of
interesting
works carried out in the last five years.
4141
Assoc Professor VALIYAVEETTIL SureshPostdoc., Max‐Planck Inst. for Polymer Research, 1997; Postdoc., Univ. of
Twente, 1992; Ph.D., Univ. of Victoria, 1992; M.Tech., Indian Inst. of
Technology, 1987; M.Sc., Calicut Univ., 1985; B.Sc., Calicut Univ., 1983
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/suresh.htm
Email: [email protected]
RESEARCH INTERESTSMy specific focuses are:• Organic/Polymer materials • Bio(nano)materials
and nanotechnology
RECENT HIGHLIGHTReference: Angewandte
Chem., 44, 5476‐5479 (2005)
Structure‐property
relationship
of
a
series
of
designer
peptides
towards
the
biomineralization
process is investigated using various experimental techniques.
PREMIUM PUBLICATIONS•
M Vetrichelvan
and S Valiyaveettil, Chem. Eur. J., 11, 5889‐5898 (2005)•
PK
Ajikumar,
S
Vivekanandan,
R
Laxminarayanan,
SDS
Jois,
RM
Kini
and
S
Valiyaveettil,
Angewandte
Chem.,
44,
5476‐5479 (2005)•
S Jegadesan, RC Advincula
and S Valiyaveettil, Nanolithographic, Advanced Materials, 17, 1282‐1285 (2005)•
R Lakshminarayanan
, EC Ooi, XJ Loh, RM Kini
and S Valiyaveettil, Biomacromolecules,
6(3),
1429‐1437 (2005)•
R Lakshminarayanan, RM Kini
and S Valiyaveettil, PNAS,
99(8), 5155‐5159 (2002)
4242
Assoc Professor Jagadese
J VITTALPostdoc., Univ. of Western Ontario, 1987; Ph.D., Indian Inst. of Science, 1982;
M.Sc., Madurai Univ., 1977; B.Sc., Univ. of Madras, 1975
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/jjvittal.htm
Email: [email protected]
MAJOR RECOGNITION•
Associate Editor, Journal of Synthesis and Reactivity in Inorganic, Metal‐Organic and Nano‐Metal
Compounds, (A Taylor and Francis Journal), 2006‐present•
Member, Editorial Boards of Main Group Metal Chemistry
(from 2003), Molecular and
Supramolecular
Chemistry (from 2007), and Current Chemical Biology
(from 2007) •
ISCAS Bronze Medal 2001 of the Indian Association of Solid State
Chemists and Allied
Scientists, India for contributions in the field of Solid State Chemistry, 2001•
DAAD‐NUS Exchange Visit Fellowship to Göttingen, Germany, June‐July, 2002 •
Royal Society of Chemistry Journal Grant Award for International
Authors, 2002
RESEARCH INTERESTSCrystal
engineering
of
hydrogen‐bonded
and
coordination
polymeric
architectures,
photochemistry
and
solid‐state
structural
transformations
involving
coordination
polymers,
chemistry
of
metal
chalcogenocarboxylates
as
molecular
precursors
for
metal
chalcogenide
materials, thin films and nanocrystals. Specific focuses are:• Inorganic chemistry & Inorganic materials• Supramolecular
chemistry & Crystal Engineering
RECENT HIGHLIGHTReference: Angew. Chem. Int. Ed.,
45, 4337‐4341 (2006)
A
solvated
linear
1D
coordination
polymer
containing
4,4’‐bipyridylethylene
has
no
parallel
dispositions
of
C=C
bonds
in
the
crystal
structure
but
undergoes
photodimerization
due
to
the
lateral
movements
of
adjacent
linear
strands
on
desolvation
forming
a
ladder‐like structure.
PREMIUM PUBLICATIONS•
M
Nagarathinam
and
JJ
Vittal,
Anisotropic
Movements
of
Coordination
Polymers
upon
Desolvation:
Solid‐state
Transformation
of
Linear
1D
Coordination
Polymer
to
Ladder‐like
Structure,
Angew.
Chem.
Int.
Ed.,
45,
4337‐4341
(2006) •
NL Toh, M Nagarathinam and JJ Vittal, Topochemical
photodimerization
in the molecular ladder metal coordination
polymer
[{(CF3
CO2
)(μ‐O2
CCH3
)Zn}2
(μ‐bpe)2
]n
(where
bpe
=
4,4’‐bipyridylethelene)
via
single‐crystal
to
single‐crystal
transformation, Angew. Chem. Int. Ed.,
44, 2237‐2241 (2005) •
B
Sreenivasulu
and
JJ
Vittal,
Helix
inside
a
Helix:
Encapsulation
of
Hydrogen‐bonded
Water
Molecules
inside
a
Staircase Coordination Polymer, Angew. Chem. Int. Ed., 43, 5769‐5772 (2004) •
MT Ng, CB Boothroyd
and JJ Vittal, One Pot Synthesis of New Phase AgInSe2
Nanorods, J. Am. Chem. Soc.
, 128, 1178‐
1179 (2006) •
MT
Ng,
C.
Boothroyd
and
JJ
Vittal,
Shape
and
size
control
of
Ag2
Se
nanocrystals
from
single
precursor
[(Ph3
P)3
Ag2
(SeC{O}Ph)2
], Chem. Commun., 3820‐3822 (2005)
4343
Dr WENG ZhiqiangPh.D., National Univ. of Singapore, 2003; B.Sc., Fuzhou Univ., 1994
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/wengzq.htm
Email: [email protected]
RESEARCH INTERESTSMy
specific focuses are:• Transition metal catalysts for olefin oligomerization/ polymerization • Transition metal catalysts for organic synthesis
RECENT HIGHLIGHTReference: Organometallics, 23, 4342 (2004)
A mixture of Pd2
(dba)3
and hemilabile
ferrocenyl
ligand
[η‐C5
H4
CH=N(C6
H5
)]Fe[η‐C5
H4
P(t‐Bu)2
],
efficiently catalyzes the Suzuki
cross‐couplings of a range of arylboronic
acids and aryl chlorides,
affording the desired biaryl
products in high isolated yields. One of catalytically active 14‐e linear
Pd(0)
intermediate,
Pd{[η‐C5
H4
CH=N(C6
H5
)]Fe[η‐C5
H4
P(t‐Bu)2
]}2
,
has
been
isolated
and
crystallographically
established.
PREMIUM PUBLICATIONS•
Z Weng, S Teo, LL Koh, TSA Hor, Angew. Chem. Int. Ed.,
44, 7560 (2005)•
Z Weng, S Teo, LL Koh, TSA. Hor, Organometallics, 23, 4342 (2004)•
Z Weng, S Teo, LL Koh, TSA. Hor, Organometallics
,
23, 3603 (2004)•
Z Weng, LY Goh, Acc. Chem. Res., 37, 187 (2004)•
LY. Goh, Z Weng, WK Leong and JJ Vittal, J. Am. Chem. Soc., 124, 8804 (2002)
4444
Asst Professor Thorsten WOHLANDPostdoc., Stanford Univ.; Ph.D., Swiss Federel
Inst. of Technology at Lausanne;
Dipl. Phys., Univ. of Heidelberg
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/tw.htm
Email: [email protected]
RESEARCH INTERESTSMy
group
works
on
the
development
of
new
fluorescence
spectroscopy
techniques
for
the
measurement of biomolecular
interactions in cells, tissues, and organisms. Specific focuses are:• Techniques: Single wavelength excitation fluorescence cross‐correlation spectroscopy (SW‐FCCS)
and EMCCD based fluorescence correlation spectroscopy• Biological systems: Transmembrane
protein receptors and peptides and their interaction with membranes (e.g. epidermal growth factor receptor, antimicrobial peptides)
PREMIUM PUBLICATIONS•
L
Yu,
JL
Ding,
B
Ho
and
T
Wohland,
Investigation
of
a
Novel
Artificial
Antimicrobial
Peptide
by
Fluorescence
Correlation
Spectroscopy:
An
Amphipathic
Cationic
Pattern
is
Sufficient
for
Selective
Binding
to
Bacterial
Type
Membranes and Antimicrobial Activity, BBA Biomembranes, 1716, 29‐39 (2005)•
L
Yu,
M
Tan,
B
Ho,
JL
Ding
and
T.
Wohland,
Determination
of
critical
micelle
concentrations
and
aggregation
numbers by fluorescence correlation spectroscopy: Aggregation of
a lipopolysaccharide, Analytica
Chimica
Acta, 556
(1), 216‐225 (2006) •
LC
Hwang,
M
Leutenegger,
M
Gösch,
T
Lasser,
P
Rigler,
W
Meier
and
T
Wohland,
Prism‐based
multicolor
fluorescence correlation Spectrometer, Optics Letters, 31(9), 1310‐1312 (2006) •
LC Hwang, M Gösch, T Lasser
andT
Wohland, Simultaneous multicolor fluorescence cross‐correlation spectroscopy to
detect higher order molecular interactions using single wavelength laser excitation, Biophys. J., 91, 715‐727 (2006) •
B
Kannan,
JY
Har,
P
Liu,
I
Maruyama,
JL
Ding
and
T
Wohland,
EMCCD‐camera
based
fluorescence
correlation
spectroscopy, Anal. Chem., 78(10), 3444‐51 (2006)
RECENT HIGHLIGHTReference: Biophys. J., 91, 715‐727 (2006)
Single
wavelength
fluorescence
cross‐correlation
spectroscopy
(SW‐FCCS)
can
determine
interaction
patterns
between
multiple
binding
partners.
The
effectiveness
of
SW‐FCCS
to
detect
binding of three interacting partners is experimentally verified
in this publication.
4545
Assoc Professor WONG M W RichardPostdoc., Yale Univ., 1991; Postdoc., IBM Kingston, 1990; Ph.D., Australian
National Univ.y, 1989; B.Sc. & B.Math, Univ. of Newcastle, 1985
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/wongmw.htm
Email: [email protected]
MAJOR RECOGNITION•
International Board member, Asian Pacific Association on Theoretical and Computational
Chemistry, 2005•
Outstanding Researcher Award, National University of Singapore, 2002•
Australian Research Fellow, Australian Research Council, 1992‐1997
RESEARCH INTERESTSComputational
quantum
chemistry,
weak
intermolecular
interactions,
organocatalysis,
free
radical
chemistry,
sulfur
chemistry,
molecular
sensors,
reaction
mechanism,
reactive
intermediates, gas‐phase ion chemistry, computational vibrational
spectroscopy, solvation
theory.
Specific focuses are:• Mechanistic study of catalyzed asymmetric organic reactions and design of novel organocatalysts
• Study of weak intermolecular interactions (CH…O, CH… π, π‐π, π*‐π*) in chemistry and biology; molecular recognition; and design of novel chemical
sensors
RECENT HIGHLIGHTReference: Chem. Eur. J., 12 (2006) in print
The
omnipresent
π*‐π*
bonding
interaction
plays
a
crucial
role
in
understanding
the
structures
and conformations of all binary sulfur‐rich oxides.
PREMIUM PUBLICATIONS•
MW Wong, Prediction of a Metastable
Helium Compound: HHeF, J. Am. Chem. Soc.,
122, 6289‐6290 (2000) •
MW Wong, Quantum‐Chemical Calculations of Sulfur‐Rich Compounds, Top. Curr. Chem., 231, 1‐30 (2003) •
MW
Wong,
On
the
Roles
of
C‐H….O=S
and
p‐stacking
Interactions
in
2‐Bromoacrolein
Complex
with
N‐tosyl‐(S)‐
tryptophan
Derived Oxazaborolidinone
Catalyst, J. Org. Chem., 70, 5487‐5493 (2005) •
J
Ran
and
MW
Wong,
Saturated
Hydrocarbon‐Benzene
Complexes:
A
Theoretical
Study
of
Cooperative
CH/π
Interaction, J. Phys. Chem. A, 110, 9702‐9709 (2006) •
MW Wong, Y Steudel
and R Steudel, Structures and Vibrational
Spectra of the Sulfur‐Rich Oxides SnO (n
= 4‐9). The
Importance of π*‐π* Interaction, Chem. Eur. J.,
12 in print (2006)
4646
Professor XU Guo QinPostdoc., Univ. of Toronto, 1991; Postdoc., Brookhaven National Lab, 1989;
Ph.D., Princeton Univ., 1987; B.Sc., Fudan
Univ., 1982
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/xugq.htm
Email: [email protected]
RESEARCH INTERESTSMy
specific focuses are:• Surface chemistry• Nano‐materials and molecular conductivity
RECENT HIGHLIGHTReference: Accounts of Chemical Research, 37(11), 882‐893 (2004)
Molecular attachment chemistry is emerging as an important approach to tailor the chemical,
physical and mechanical properties of silicon surfaces as well as for incorporating organic
functions into silicon‐based devices for various technological needs. This article reviews the
recent progress and current understanding of reactivity, selectivity and mechanisms of organic
molecules on Si(111)‐7×7.
PREMIUM PUBLICATIONS•
F Tao, ZH Wang, YH Lai and GQ Xu, Journal of The American Chemical Society, 125(22), 6687‐6696, (2003)•
F Tao, XF Chen, ZH Wang and GQ Xu, Journal of The American Chemical Society, 124(24), 7170‐7180 (2002)•
F Tao, WS Sim, GQ Xu GQ and MH Qiao, Journal of The American Chemical Society, 123(38), 9397‐9403 (2001)•
Y Cao, ZH Wang, DF Deng and GQ Xu, Angewandte Chemie‐International Edition, 39(15), 2740‐2743 (2000)•
Y
Cao,
KS
Yong,
ZQ
Wang,
WS
Chin,
YH
Lai,
JF
Deng,
GQ
Xu,
Journal
of
The
American
Chemical
Society,
122(8),
1812‐1813 (2000)
4747
Asst Professor XU Qing‐HuaPostdoc., UC Santa Barbara, 2005; Postdoc., Stanford Univ., 2002; Ph.D., UC
Berkeley, 2001; B.Sc., Zhejiang
Univ., 1993
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/xuqh.htm
Email: [email protected]
RESEARCH INTERESTSWe are interested in the development and application of novel temporally and spatially resolved
optical
spectroscopic
methods
to
study
low‐dimensional
materials,
biomacromolecules
and
fundamental
chemical
processes,
to
understand
their
structure‐dynamics‐function
relationship.
Specific focuses are:• Nonlinear optics and laser spectroscopy• Materials physics and biophysics
PREMIUM PUBLICATIONS•
Q‐H Xu, S Wang, D Korystov, A Mikhailovsky, GC Bazan,
D
Moses and
AJ Heeger, Fluorescence
Resonance Energy
Transfer Gate in DNA Sequence Detection: a Time‐Resolved Study, PNAS, 102, 530‐535 (2005) •
Q‐H Xu, BS Gaylord,
S Wang, GC Bazan,
D
Moses
and
AJ
Heeger,
Time‐resolved
energy
transfer
in
DNA
sequence
detection using water‐soluble conjugated polymers: the role of electrostatic and hydrophobic interactions, PNAS, 101
11634‐11639 (2004) •
KA Merchant, Q‐H Xu, DE Thompson, and MD Fayer, Frequency Selected Ultrafast
Infrared Vibrational
Echo Studies
of Liquids, Glasses and Proteins, J. Phys. Chem. A, 106, 8839‐8849 (2002) •
Q‐H Xu, Y‐Z Ma and GR Fleming, Different Real and Imaginary Components of Third‐Order Polarization Revealed by
Optical Heterodyne Detected Tranient
Grating Spectroscopic Studies in Crystal Violet: Model and Experiments, J.Phys.
Chem. A., 106, 10755‐10763 (2002) •
Q‐H
Xu,
Y‐Z
Ma
and
GR
Fleming,
Heterodyne
Detected
Transient
Grating
Spectroscopy
in
Resonant
and
Non‐
resonant Systems Using a Simplified Diffractive Optics Method, Chem. Phys. Lett., 338, 254‐262 (2001)
RECENT HIGHLIGHTReference: Chem. Comm, submitted
Nanocomposites
consisting of a
metal
core,
a
silica‐spacer
shell
with
controlled
thickness,
and
a
dye‐labelled
shell
were
synthesized
and
separation
distance
dependent
fluorescence
enhancement of fluorescein
isothiocyanate
by silver nanoparticles
was studied.
4848
Asst Professor XUE FengPostdoc., The Wistar
Institute, 2005; Ph.D., The Chinese Univ. of Hong Kong,
2000; B.Sc., Tsinghua
Univ., 1993
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/xf.htm
Email: [email protected]
RESEARCH INTERESTSMy specific focuses are:• Crystal engineering, supramolecular
chemistry• Protein crystallography, structural biology
RECENT HIGHLIGHTReference: J. Am. Chem. Soc., 122, 9860‐9861 (2000)
The design and construction of hydrogen‐bonded ʺsupramolecular
rosettesʺ from guanidinium
/
organic
sulfonate,
trimesic
acid,
or
cyanuric
acid
/
melamine
depend
on
utilization
of
their
topological
equivalence,
i.e.,
equal
numbers
of
donor
and
acceptor
hydrogen‐bonding
sites
and
C3 symmetry of the component moieties .
PREMIUM PUBLICATIONS•
C‐K Lam, F Xue, J‐P Zhang, X‐M Chen and TCW Mak, J. Am. Chem. Soc., 127, 11536‐11537 (2005)•
R Thaimattam, F Xue, JARP Sarma
and TCW Mak, G.R. Desiraju, J. Am. Chem. Soc., 123, 4432‐4445 (2001)•
TCW Mak
and F Xue, J. Am. Chem. Soc., 122, 9860‐9861 (2000)•
F Xue and TCW Mak, Acta Crystallogr.
B, 56, 142‐154 (2000)•
F Xue
and TCW Mak, J. Phys. Org. Chem., 13, 405‐414 (2000)
4949
Assoc Professor YAO Shao
QinPostdoc., Scripps Research Institute, 2001; Postdoc., Univ. of California
Berkeley, 1999; Ph.D., Purdue Univ., 1998; B.Sc., Ohio State Univ., 1993
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/yaosq.htm
Email: [email protected]
MAJOR RECOGNITION•
Scientific Advisory Board,
Molecular BioSystems,
2005 •
Young Research Award, National University of Singapore, 2005 •
Young Investigator Award, A*STAR Singapore, 2002
RESEARCH INTERESTS“Catalomics”
‐
We
are
interested
in
developing
powerful
strategies
in
Chemical
Biology
and
Chemical
Proteomics
that
enable
organism‐wide,
high‐throughput
studies
of
enzymes.
Specific
focuses are:• Chemical Biology• Medicinal Chemistry
RECENT HIGHLIGHTReference: Chem. Commun., 3783‐3785 (2006)
By using “Click Chemistry”, we report the facile synthesis of various affinity‐based hydroxamate
probes
that
enable
generation
of
activity‐based
fingerprints
of
a
variety
of
metalloproteases,
including matrix metalloproteases
(MMPs), in proteomics experiments.
PREMIUM PUBLICATIONS•
R
Srinivasan,
M
Uttamchandani
and
SQ Yao, Rapid assembly and
in situ
screening of bidentate
inhibitors of
protein
tyrosine phosphatases
(PTPs), Org. Lett., 8, 713‐716 (2006) •
Y
Hu,
GYJ
Chen,
SQ
Yao,
Activity‐based
high‐throughput
screening
of
enzymes
using
DNA
microarray,
Angew.
Chem. Intl. Ed., 44, 1048‐1053 (2005) •
EWS Chan, S Chattopadhaya, RC Panicker, X Huang, SQ Yao, Developing photo‐active affinity probes for proteomic
profiling: hydroxamate‐based probes for metalloproteases, J. Am. Chem. Soc., 126, 14435‐14446 (2004) •
GYJ
Chen,
M
Uttamchandani,
Q
Zhu,
G
Wang
and
SQ
Yao,
Developing
a
strategy
for
activity‐based
detection
of
enzymes in a protein microarray, ChemBiochem, 4, 336‐339 (2003) •
ML Lesaicherre, RYP Lue, GYJ Chen, Q Zhu and SQ Yao, Intein‐mediated biotinylation
of proteins and its application
in a protein microarray, J. Am. Chem. Soc., 124, 8768‐8769 (2002)
5050
Assoc Professor YIP Hon Kay JohnPostdoc., Caltech, 1997; Postdoc., Technical Univ. of Munich, 1995; Ph.D.,
Univ. of Hong Kong, 1993; B.Sc., Univ. of Hong Kong, 1989
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/yipjohn.htm
Email: [email protected]
RESEARCH INTERESTSMy general interests lie on
supramolecular
chemistry and
physical inorganic
chemistry.
Specific
focuses are:• Self‐assembly and dynamics of metallosupramolecular
systems • Design and Synthesis of Luminescent Metal Complexes and molecular wires
RECENT HIGHLIGHTReference: Inorganic Chemistry (2006) In press
This work shows the presence of
a
dynamic
equilibrium
between
silver‐metallacyles
and
helical
polymers in solution. A ring opening mechanism is proposed for the exchange in acetonitrile.
PREMIUM PUBLICATIONS•
JHK
Yip,
J
Wu,
K‐Y
Wong,
KP
Ho,
CS‐N
Pun
and
JJ
Vittal,
Electronic
Communication
Mediated
by
Pt‐Pt
s‐bond,
Organometallics, 21, 5292‐5233 (2002)•
R Lin, JHK Yip, K Zhang, LL Koh, KY Wong, KP Ho, Self‐assembly and Molecular Recognition of a Luminescent Gold
Rectangle, J. American Chemical Society, 126, 15852‐15869 (2004)•
K Zhang, J Prabhavathy, JHK Yip, LL Koh, GK Tan, JJ Vittal, First Examples of AuI‐X‐AgI
Halonium
Cations
(X = Cl‐
and Br‐), J. American Chemical Society, 125, 8452‐8453 (2004)•
S.
Muthu, JHK Yip and JJ Vittal,
Coordination
Networks
of
Ag(I)
and
N,N’‐
Bis(3‐Pyridinecarboxamide)‐1,6‐Hexane:
Structures and Anion Exchange, J. Chem. Soc., Dalton Trans, 4561‐4568 (2002)•
JHK
Yip
and
J
Prabhavathy,
A
Luminescent
Gold
Ring
That
Flips
Like
Cyclohexane,
Angewandte
Chemie
International Edition
, 40, 2159 –
2162 (2001)
Ag3 ring Ag4 ring helical polymer
5151
Asst Professor ZENG HuaqiangPostdoc., UC Santa Barbara, 2005; Postdoc., Stanford Univ., 2002; Ph.D., UC
Berkeley, 2001; B.Sc., Zhejiang
Univ., 1993
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/zenghq.htm
Email: [email protected]
RESEARCH INTERESTSThe
central
theme
in
our
research
group
is
focused
on
the
applications
of
broadly
defined,
bioinspired
Supramolecular
Chemistry
to
address
many
challenging
issues
at
the
interface
of
chemistry and biology. Specific focuses are:• Synthetic ion channels• High‐throughput screening systems widely suitable for discovering highly efficient, stereoselective
catalysts of varying kinds for catalyzing wide‐ranging chemical transformations• Catalytic drugs that can catalytically cleave any chosen disease‐causing proteins
PREMIUM PUBLICATIONS•
H Zeng, J
Xie
and
PG
Schultz,
Genetic
introduction
of
a
diketone‐containing
amino
acid
into
proteins,
Bioorg.
Med.
Chem. Lett., 16, 5356‐5359 (2006) •
H Zeng, X Yang, B Gong, etc, An extremely stable, self‐complementary hydrogen‐bonded duplex. Chem. Commun., 13,
1556–1557 (2003) •
B
Gong,
H
Zeng,
J
Zhu,
etc,
Creating
nanocavities
of
tunable
sizes:
Hollow
helices.
Proc.
Natl.
Acad.
Sci.
USA,
99,
11583‐11588 (2002) •
H Zeng,
X Yang, RA
Flowers,
II
and B Gong,
A
Non‐Covalent
Approach to
Anti‐Parallel β‐Sheet
Formation, J. Am.
Chem. Soc., 124, 2903‐2910 (2002) •
H
Zeng,
RS
Miller,
RA
Flowers,
II
and
B
Gong,
A
Highly
Stable,
Six‐Hydrogen‐Bonded
Molecular
Duplex,
J.
Am.
Chem. Soc., 122, 2635‐2644 (2000)
RECENT HIGHLIGHTReference: Proc. Natl. Acad. Sci. USA, 99, 11583‐11588 (2002)
To
capture
Nature’s
astonishing
ability
in
creating
sophisticated
folding
biopolymers
with
nanosized
cavities,
we
have
developed
a
general
strategy
for
designing
folded
structures
with
modifiable
outer
surfaces
and
easily
tunable
interior
cavities,
which
may
find
important
applications in catalysis, separation & molecular recognition, etc.
5252
Dr ZHAO JinPh.D., Technological Univ. of Munich, 2005; M.Sc., Chinese Academy of
Science, 1995; B.Sc., Liaoning
Univ., 1992
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/zhaoj.htm
Email: [email protected]
RESEARCH INTERESTSGeneral interest falls on Organometallic
chemistry and catalysis. Specific focuses are:• Organometallic
chemistry of metals with high oxidation state and their application in oxidation catalysis
• Nickel and chromium complexes and their application in selective catalytic oligomerisation
of ethylene
PREMIUM PUBLICATIONS•
M Zhou, J
Zhao, J
Li,
S Yue, C Bao, J
Mink,
S Zang
and
FE Kühn,
MTO
Schiff
Base
Complexes:
Synthesis,Structures
and Catalytic Application in Olefin Epoxidation, Chem. Eur. J., accepted (2006) •
J
Zhao,
E
Herdtweck
and
FE
Kühn,
Chiral
ansa‐bridged η5‐
Cyclopentadienyl
Molybdenum
Complexes:
Synthesis,
Structure and Application in Asymmetric Olefin Epoxidation, , J. Organomet. Chem., 691,
2199‐2206 (2006) •
J Zhao, A Sakthivel, AM Santos and FE Kühn, Cyclopentadienyl‐Molybdenum Complexes with a Siloxane
Functional
Group as Models for Efficient Hetrogeneous
Epoxidation
Catalysts, Inorg. Chim. Acta,
358, 4201‐4207 (2005) •
A
Sakthivel,
J
Zhao,
M
Hanzlik,
AST
Chiang,
WA
Herrmann
and
FE
Kühn,
Heterogenization
of
organometallic
molybdenum complexes with siloxane
functional groups and their catalytic application, Adv. Synth. Catal., 347,
473‐
483 (2005) •
J
Zhao,
AM
Santos,
E
Herdtweck
and
FE
Kühn,
Molybdenum
and
Tungsten
Complexes
of
Composition
(η5‐
C5
R5
)MR’(CO)3
and Their Use as Olefin Epoxidation
Catalyst Precursors, J. Mol. Catal. A. Chem., 222, 265‐271 (2004)
RECENT HIGHLIGHTReference: Chem. Eur. J., (2006) accepted
Several
Schiff
base
ligands
form
readily
complexes
with
methyltrioxorhenium(VII)
(MTO),
undergoing
a
H‐transfer
from
a
ligand
bound
OH‐group
to
a
ligand
N
atom.
The
catalytic
behavior
of
epoxidation
of
olefins
is
influenced
significantly
by
the
Schiff
bases
coordinated
to
the MTO moiety.
OH
NHC
R' ReO
OOH3C
ROH
NHC
R'
RRe
CH3
O OO
+Diethyl ether
r.t.
R'= H,R= H (1); R'= H, R= p-CH3 (2); R'= H, R= p-Cl (3); R'= H, R= p-OCH3 (4); R'= -OCH3;R= p-CH3 (5)
5353
Assoc Professor ZHOU WeibiaoPostdoc., Univ. of Waterloo, 1991; Ph.D., Univ. of Queensland, 1991; M.Eng,
Chinese Academy of Sciences, 1985; B.Sc., Beijing Univ. of Chemical
Technology, 1982
http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/zhouwb.htm
Email: [email protected]
MAJOR RECOGNITION•
Member, International Editorial Board, International Journal of Food Engineering (USA), 2004
onwards •
Member, International Editorial Board, Food Manufacturing Efficiency (UK), 2006 onwards •
Appointed Member of the Nominations Advisory Committee, International Union of Food
Science & Technology (IUFoST), 2001‐2003, 2003 ‐2006 •
Member‐at‐large, Executive Committee, International Society of Food Engineering (ISFE), 2006
onwards
RESEARCH INTERESTSMy
interests
lie
on
food
processing
and
food
engineering;
particularly
baking
processes,
dairy
processes, food process modelling
and optimisation,
advanced
process
control,
and
the effect
of
food
processing
on
some
functional
components
such
as
isoflavones
and
antioxidants.
Specific
focuses are:• Modeling, optimisation, and advanced control of food processes• Effect of processing on functional components of food
RECENT HIGHLIGHTReference: J. Food Engineering, 77(4), 784‐791 (2006)
The
robustness
of
a
Computational
Fluid
Dynamics
(CFD) model for bread baking to some uncertainties
in
the
physical
properties
of
dough/bread
is
addressed
in
this
paper.
Temperature
profiles
at
eight
different
locations
in
bread
and
oven
were
analyzed.
Analysis
of
the
experimental
results
showed
that
density
and
heat
capacity
were
the
more influential factors.
PREMIUM PUBLICATIONS•
MK Mya, W Zhou and CO Perera, A study of the mass transfer in osmotic dehydration of coated potato cubes, Journal
of Food Engineering, 77(1), 84‐95 (2006)•
R
Wang,
and
W
Zhou,
Stability
of
tea
catechins
in
the
breadmaking
process,
Journal
of
Agricultural
and
Food
Chemistry, 52(26), 8224‐8229 (2004) •
W
Zhou,
Application
of
FDM
and
FEM
to
solving
the
simultaneous
heat
and
moisture
transfer
inside
bread
during
baking, International Journal of Computational Fluid Dynamics, 19(1), 73‐77 (2005) •
W
Zhou,
S
Dong,
and
PL
Lee,
Exponential
Tracking
with
Disturbance
Attenuation
(ETDA)
by
Output
Feedback,
Computers & Chemical Engineering, 26(9), 1231‐1239 (2002) •
N Therdthai
and W Zhou, Artificial Neural Network Modelling
of the Electrical Conductivity Property of Recombined
Milk, Journal of Food Engineering, 50(2), 107‐111 (2001)
Velocity profile in the oven by CFD
5454
HONOURS STUDENT COHORT 2006
5555
GRADUATE STUDENT COHORT 2006
5858