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American Academy of Pediatrics Guidelines, 2007
Colleen A. Kraft, M.D., FAAP
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The Basics of AutismOnset during first 3 years of lifeChronic lifelong courseMale:female ratio = 4:1Underlying neurological dysfunctionGenetic factors in etiologySpectrum of severity
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Autism BasicsKanner’s Description
Leo Kanner (1943) classic paper Description of 11 children with previously undescribed syndrome
Characteristics Inability to relate to others Failure to use language to convey meaning Obsessive desire for the maintenance of sameness Anxiety Congenital onset Co-morbidity
Observations to empirical support
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Clinical FeaturesFive specific spectrum diagnoses used by
DSM-IV:Autistic disorderAsperger disorderRett disorderChildhood disintegrative disorderPervasive developmental disorder-NOS
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The Autism SpectrumMilder disorders
Asperger syndrome Fewer symptoms, no language delay
Pervasive Developmental Disorder-NOS
Sub-clinical manifestations The broader autism phenotype in family members
Language delay Shyness, social reticence Rigidity, focused interests
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DSM-IV Core Characteristics: Criteria for Autistic DisorderDeficits in reciprocal social interaction
Impairments in verbal and nonverbal communication
Restricted, repetitive or stereotyped behaviors and interests
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Meeting Criteria For AutismIndividual must demonstrate at least 6 of
the 12 symptoms
At least 2 symptoms from the social domainAt least 1 symptom from communication
domainAt least 1 symptom from the restricted
behaviors/interest domainAt least 1 symptom must have been present
before 36 months of age
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Since Kanner: What Do We Know?Autism is a Spectrum DisorderAutism Spectrum Disorders are Not RareAutism is a Developmental DisorderAutism is a Neurodevelopmental Disorder with
a Biological BasisAutism Can be Identified Early
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Autism Spectrum Disorders Are CommonIncrease in prevalence
3-4 times higher than suggested in 1970s1.5 times higher than thought in 1980s and
1990sProposed explanations:
Better identification Sensitive diagnostic tools Broader classification systems Environmental factors
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Autism is a Developmental DisorderAccurate diagnosis of autism required
significant knowledge of typical development in the following areas: social, communication, cognitive skills, and play skills.
Understanding developmental profiles: must know what is typical for development and atypical for development at any age.
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Autism is a Neurodevelopmental Disorder with a Biological BasisGenetic factors
Recurrence risk for autism after the birth of one child with disorder is 3-6%
Concordance rate for autism in monozygotic twins is 60% (and up to 90% when social and communication abnormalities included)
Genome projects and molecular genetic studies
Broader Phenotype factorsOrganic Brain Disorder
fMRI, MRI studies demonstrate: increased head circumference, brain volume, brain region deficits
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Autism Can Be Identified Early
Most common initial symptom reported by parents is delayed (or abnormal) speech development
Social-communicative abnormalities in the first and second year of life:
Eye contact Social referencing Imitation Orientation to name Shared attention and affect
Early recognition and identification of autism-->early behavioral markers of autism
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Autism…What We KnowBetween 60,000 and 115,000 children under 15
years of age in the US meet diagnostic criteria for autism.
The diagnosis of autism often is not made until 2-to-3 years after symptoms are recognized, primarily due to concerns about labeling or incorrectly diagnosing the child.
Identifying children with autism and initiating intensive, early intervention during the preschool years results in improved outcomes for most young children. Early diagnosis of autism and early intervention facilitates earlier educational planning.
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Family ExperiencesOut of 1,300 families surveyed:
The average age of diagnosis of autism was 6 years of age, despite the fact that most parents felt something was wrong by 18 months of age
Less than 10% of children were diagnosed at initial presentation
10% were either told to return if their worries persisted, or that their child "would grow out of it"
The rest were referred to another professional (at a mean age of 40 months); of which: 40% were given a formal diagnosis 25% were told "not to worry" 25% were referred to a third or fourth professional
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AAP GuidelinesIdentification requires two levels of investigation.
Screening and SurveillanceDiagnosis/Referral and Coordination of Care
For these two areas of investigation, specific clinical questions were defined, clinical evidence was summarized, and diagnostic recommendations were developed.
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Developmental Surveillance and Screening
• Should be performed on all children. • Involves first identifying those at risk for any type of
atypical development, followed by identifying those specifically at risk for autism.
• Mental retardation or other medical or neurodevelopmental conditions require separate evaluations and are not within the scope of this document.
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Developmental ScreeningApproximately 25% of children in any primary care
practice show developmental issues. Fewer than 30% of primary care providers conduct
standardized screening tests at well-child appointments.
The American Academy of Pediatrics (AAP) stresses the importance of a flexible, continual developmental surveillance process at each well-child visit, and recommends eliciting and valuing parental concerns, probing regarding age-appropriate skills in each developmental domain, and observing each child.
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Developmental Screening ToolsDevelopmental screening tools are formulated
based on screening of large populations of children with standardized test items.
Sensitive and specific screening instruments include: the Ages and Stages Questionnaire, the BRIGANCE® Screens, the Child Development Inventories, and the Parents’ Evaluations of Developmental Status.
The Denver-II has been the traditional tool used for developmental screening, research has found that it is insensitive and lacks specificity.
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How Are Norms Defined?Conventional language milestones are based on normative data from
standardized language instruments for infants. Failure to meet these milestones is associated with a high probability of a developmental disability.
Lack of acquisition of the following milestones within known accepted and established ranges is considered abnormal:
no babbling by 12 monthsno gesturing (e.g., pointing, waving bye-bye) by 12 months no single words by 16 months no 2-word spontaneous (not just echolalic) phrases by 24
months any loss of any language or social skills at any age
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Parental ConcernIn several studies (n=737 children), parental
concerns about speech and language development, behavior, or other developmental issues were highly sensitive (i.e., 75% to 83%) and specific (79% to 81%) in detecting global developmental deficits.
The absence of such concerns had modest specificity in detecting normal development (47%).
In a study that combined parental concern with a standardized parental report found this to be effective for early behavioral and developmental screening in the primary care setting.
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How Early?There are no biological markers for autism, so
screening must focus on behavior. Studies comparing autistic and typically
developing children show problems with eye contact, orienting to one’s name, joint attention, pretend play, imitation, nonverbal communication, and language development are measurable by 18 months of age.
Current screening methods may not identify children with milder variants of autism, those without mental retardation or language delay
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Autism in Siblings?The incidence of autism in the general
population is 0.2%, but the risk of having a second (or additional) autistic child increases almost 50-fold to approximately 10 to 20%.
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Best Practice for Screening for ASDAutism can be identified in very young
children.
Screening for ASD should be conducted in conjunction with routine developmental surveillance.
Because parents are the experts regarding their children, eliciting and valuing parental concerns is imperative.
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Screening Instruments for ASDScreening tools specific to ASD:
The Checklist for Autism in Toddlers (CHAT)The Modified Checklist for Autism in Toddlers
(M-CHAT)The Screening Tool for Autism in Two-Year-Olds
(STAT)The Stage 2-Pervasive Developmental Disorders
Screening Test (PDDST-II)
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Screening Tool: M-CHATM-CHAT (Robins et al., 2001) is 23-item checklist
designed as a screen fro ASD at 24 months of age.
Form consists of yes/no format that parents fill out.
Spanish translation available.
Demonstrated validity in identifying the majority of children with ASD and developmental delay at 24 months
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Screening Tool: M-CHATSample items from M-CHAT
Does your child look at your face to check your reaction when faced with something unfamiliar?
Does your child ever use his/her index finger to point, to indicate interest in something?
Does your child ever bring objects over to you (parent) to show you something?
Does your child respond to his/her name when you call?
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ASD Screening in Conjunction with Routine Developmental Surveillance Best practices recommend that all children be screened specifically
for ASD at ages 18 and 24 months.
Clinical signs or “red flags” exist that can help identify children at risk for delay and/or ASD. Indicators include: No babbling by 12 months of age No back and forth gestures such as pointing, showing, reaching, waving
by 12 months No words by 16 months No two-word meaningful phrases (does not include imitation or
repetition) by 24 months ANY loss of speech, babbling or social social skills at ANY age.
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Elicit and Value Parental ConcernsAll professional encounters with young children should be
viewed as an opportunity to elicit developmental information.
Advantages (Glascoe, 1999):
Concerns are easy to elicit Inquiry is brief Does not involve challenge of eliciting skills from young children Provides family-centered approach to addressing problems Can facilitate a wide range of options including parenting
education, reassurance, referral, or further screening or developmental testing
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Recommendations1. Developmental surveillance should be performed
at all well-child visits from infancy through school-age, and at any age thereafter if concerns are raised about social acceptance, learning, or behavior (Guideline).
2. Recommended developmental screening tools include the Ages and Stages Questionnaire, the BRIGANCE® Screens, the Child Development Inventories, and the Parents’ Evaluations of Developmental Status (Guideline).
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Recommendations3. Because of the lack of sensitivity and specificity, the
Denver-II (DDST-II) and the Revised Denver Pre-Screening Developmental Questionnaire (R-DPDQ) are not recommended for appropriate primary-care developmental surveillance (Guideline).
4. Further developmental evaluation is required whenever a child fails to meet any of the following milestones (Guideline): babbling by 12 months; gesturing (e.g., pointing, waving bye-bye) by 12 months; single words by 16 months; two-word spontaneous (not just echolalic) phrases by 24 months; loss of any language or social skills at any age.
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Recommendations5. Siblings of children with autism should be carefully
monitored for acquisition of social, communication, and play skills, and the occurrence of maladaptive behaviors. Screening should be performed not only for autism-related symptoms but also for language delays, learning difficulties, social problems, and anxiety or depressive symptoms (Guideline).
6. Screening specifically for autism should be performed on all children failing routine developmental surveillance procedures using one of the validated instruments—the CHAT or the Autism Screening Questionnaire (Guideline).
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Screening ResultsScreening results are
consistent with typical development. No signs of developmental delays or risk factors identified.
Screening results are consistent with typical development; however, presence of risk factors.
Screening results indicate a possible delay or disorder. Risk factors may be identified.
Routine monitoring
Referral for services and supports & heightened monitoring
Assessment, referral for services and supports as needed, & heightened monitoring
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Referral of Child with Possible ASDConfusion surrounding referral process--major
barrier to screening: Need resource directory, contacts for individuals and teams,
referral process explanation, etc.
Next Steps: Conveying information to families Supporting Documentation for referral
Where to Refer: Developmental Pediatrician Part C School System
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Diagnosis1. Who should diagnose autism?
2. What are the medical and neurologic concerns in evaluating children with autism?
3. What are the specific deficits of the autistic child’s developmental profile?
4. When and what laboratory investigations are indicated for the diagnosis of autism?
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DiagnosisAlthough educators, parents, and other health care
professionals identify signs and symptoms characteristic of autism, a clinician experienced in the diagnosis and treatment of autism is usually necessary for accurate and appropriate diagnosis.
Clinicians must rely on their clinical judgment, aided by guides to diagnosis, such as DSM-IV as well as by the results of various assessment instruments, rating scales, and checklists.
These instruments and criteria should be used by practitioners not as experienced in the diagnosis of autism.
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Core Concepts that Guide Screening, Diagnosis and Assessment in AutismDSM-IV is current classification standard for
establishing diagnosis of ASD.
Early identification is essential for early therapeutic intervention and leads to a higher quality of life for family and child.
Informed clinical judgment is a required element of a screening, diagnostic and assessment process.
Accurate screening and assessment requires collaboration and problem solving among professionals, service agencies and families
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Core Concepts that Guide Screening, Diagnosis and Assessment in AutismAn interdisciplinary process is the recommended
means for developing a coherent and inclusive profile for an individual at risk for or diagnosed with ASD.
From screening through intervention planning, the evaluation process must be family-centered and culturally sensitive.
From time of screening--timely referral and coordination of evaluation and ongoing assessment enhances outcome.
Rapid developments in the field require regular review of current best practice procedures and up-to-date training
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Medical ConcernsFamilial prevalence Family studies have shown that
there is a 50-to-100-fold increase in the rate of autism in first-degree relatives of autistic children.
Large head circumference without frank neuropathology Children with autism have a larger head circumference; only a small proportion have frank macrocephaly.
Association with tuberous sclerosis complex (TSC) and less often with Fragile X (FraX) syndrome Seventeen to over 60% of mentally retarded individuals with TSC are also autistic, and these patients commonly have epilepsy. Clinical studies report that 3% to 25% of patients with FraX have autism.
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Laboratory TestingGenetic testing A chromosomal abnormality
reported in possibly more than 1% of autistic individuals involves the proximal long arm of chromosome 15 (15q11-q13), which is a greater frequency than other currently identifiable chromosomal disorders.
Metabolic testing Inborn errors in amino acid, carbohydrate, purine, peptide, and mitochondrial metabolism, as well as toxicologic studies have been studied, but the percentage of children with autism who have a metabolic disorder is probably less than 5%.
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Imaging and EEGElectrophysiologic testing The prevalence of
epilepsy in autistic children has been estimated at 7% to 14%, A higher incidence of epileptiform EEG abnormalities in autistic children with a history of regression has been reported when compared to autistic children with clinical epilepsy.
Neuroimaging CT and MRI studies of autistic children screened to exclude those with disorders other than autism confirmed the absence of significant structural brain abnormalities
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Other Tests?Formal audiologic evaluation All children with
developmental delays, particularly those with delays in social and language development, should have a formal audiologic hearing evaluation (American Speech–Language–Hearing Association).
Lead screening The National Center for Environmental Health of the Centers for Disease Control and Prevention recommends that children with developmental delays, even without frank pica,
should be screened for lead poisoning.
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Insufficient Evidencehair analysis for trace
elements celiac antibodies allergy testing
(particularly food allergies for gluten, casein, candida, and other molds)
immunologic or neurochemical abnormalities
micronutrients such as vitamin levels
intestinal permeability studies
stool analysis urinary peptides mitochondrial disorders
(including lactate and pyruvate)
thyroid function tests erythrocyte glutathione
peroxidase studies
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Autism GuidelinesScreening with SurveillanceParent ConcernsHow to handle “at risk”Medical testingReferral for further diagnosisCoordinated care and Medical Home
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