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DRUGS USE TO TREAT ANEMIAPrepared by:Dr Touseef (BUMDC)
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Hematopoiesis
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Usual Criteria of Hb in ANEMIA
> 11.5 G/dl in women
> 14 G/dl in men
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Signs and Symptoms:Patients with a Hb less than 7G/dl will have appear following symptoms ;
Tissue hypoxia
Fatigue
Headache
Dyspnea
Pallor
Angina
Tachycardia
Visual impairment
Syncope
Lymphadenopathy
Hepatic and or splenic enlargement
Bone tenderness
Blood loss in feces
Neurologic symptoms.
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Classification of anemia:
1. Anemia associated with decrease RBC production Iron deficiency anemia, Megaloblastic anemia Thalassemia Anemia due to chronic disease and renal failure.2. Anemia due to increased RBC destruction: Haemolytic anemia sickle cell anemia
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Iron:
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IRON REQUIREMENT
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CAUSES OF IRON DEFECIENCY ANEMIA
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Treatment of iron deficiency Anemia
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Indication for the use of iron
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Iron Toxicity
Deferasirox– an oral iron chelator approved for treatment of iron
overload
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2- Coblamine vit B12
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Pharmacokinetics:
• Source: Meat (liver), eggs, & dairy products.• coblamine is absorbed from the GIT in the presence of intrinsic
factor, a product of the parietal cells of the stomach. • Plasma transport is accomplished by binding to transcobalamin II. • Coblamine is stored in the liver in large amounts; a normal
individual has enough to last 5 years.
It is available in 2 forms
1. cyanocobalamine
2. hydroxy cobalamine has a longer circulating half life.
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•Deficiency leads to anemia, gastrointestinal symptoms, andneurologic abnormalities.•Deoxyadenosyl cobalamin•methylcobalamin•Cyanocobalamin•hydroxocobalamin•Source of vitamin BI2
• meat (especially liver), eggs, and dairyproducts.•Vitamin B12 is sometimes called extrinsic factor
active forms of the vitamin in humans
found in food sources are converted to the active forms
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PHHARMACOKINETIC
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25
Uses:1- Pernicious Anemia :
(defective secretion of intrinsic factor by the
gastric mucosal cells)
2- Neurologic abnormalities:
3- Gastrectomy
4- Cyanide poisoning.
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26
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Why folic acid give with vitB12
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Folic acid
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Erythropoietin
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