Conference Proceedings
rth26 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
EMBC
2004
LINKAGES FOR INNOVATION
IN BIOMEPICINE
SAN FRANCISCO, USA
l~5September2004San Francisco, California
Volume IV
Conference Chair
Donna Hudson, Ph.D.Program Chair
Zhi-Pei Liang, Ph.D.
Publications Chair
GuyDumont, Ph.D.
Iwant pi Inmbluiin
EMBCO"
TIB/UB Hannover
126 450 374
89
Five-Band Microwave Radiometer Systemfor
Non-Invasive Measurement ofBrain
Temperature in New-Born Infants: SystemCalibration and its FeasibilitySugiura, T.; Kouno, Y.; Hashizume, A.; Hirata, H.;
Hand,J.W.;Okita,Y.;Mizushina,S. 2292
Images Reproducibility ofan Electrical
Impedance Tomography (EIT) Prototype.
Analysis ofthe EITSensibility in Rats in
Pathological in vivo Conditions
Gaona, Andres G.; Aguillon, Miguel A. P.;
Mendoza, A. Jesus; L6pez, Leonor M.; Gonzalez,
EvaT. 2296
Digital Phonocardiography: A PDA-based
ApproachNazeran, Homayoun; Brusco, Matias 2299
ExperimentalStudy of3D Contactless
Conductivity Detection using Microwave
Radiometry: aPossible MethodforInvestigation
ofBrain Conductivity Fluctuations
Karanasiou, Irene S.; Uzunoglu, Nikolaos K. 2303
Therapy Guidedby GastricImpedanceSpectroscopy in a Septic Shock Model in PigsGonzalez, Cesar A.; Villanueva, Cleva; Othman,
Salah; Sacristan, Emilio 2307
Session 3.7.5: PhysiologicalMeasurements II
4 Respiration Monitor Based on
Electrocardiographic and
Photoplethysmographic Sensor Fusion
Ahlstrom, Christer; Johansson, Anders; Lanne,Toste; Ask, Per 2311
Laser Doppler Method in Evaluation of
Vasovagal SyncopeInduced by Tilt Table Test
Maniewski, Roman; Szufladowicz, Ewa; Nosek,
Angelika; Walczak, Franciszek 2315
Direct Coextensive Plethysmographyfor Non-Invasive Measurement ofSystemic Pressuresand Volumes
Davis, Charles L.; Thong, Iran; Belzberg,Howard; Phillips, Charles;Holden, William E.; Thornburg, Kent L. 2318
Brain Electrical Impedance at Various
Frequencies: The Effect ofHypoxiaSeoane, Fernando; Lindecrantz, Kaj; Olsson,Torsten; Kjellmer, Ingemar;Flisberg, Anders; Bagenhokn, Ralph 2322
Continuous Blood Pressure Monitoring Utilizinga CMOS Tactile Sensor
Salo, Tomi; Kirstein, Kay-Uwe; Sedivy, Jan;Grunenfelder, Jurg; Vancura, Tobias;Zund, Gregor; Baltes, Henry 2326
A Low-Cost Optical Pachymeterfor the
Diagnosis ofGlaucoma and Ocular HypertensionShaver, Jesse H.; Shen, Jin H.; Walker, Aaron L. 2330
Measurement ofAirflow through a MeteredDose
Inhaler during MRI
Delanvar, Soheil; Schmalfiiss, Ilona; Melker,Richard J.; van Oostrom, Johannes H. 2334
Session 3.7.6: PhysiologicalMeasurements III
Visualization ofLumbar Muscle Contraction
Synergy using Surface Electrography(sEMG)Streaming TopographyHu, Yong; Mak, Joseph N. F.; Lu, W. W.; Luk, K.
D.K.
A Low Cost Doppler Systemfor Vascular DialysisAccess Surveillance
Molina, Paulo S. C.
Evanescent Cavity Ring-Down Spectroscopy (e-
CRDS) ofHemoglobin Absorption at the
Silica-Water InterfaceMartin, W. Blake; Mirov, Sergey; Marryshkin,Dmitri; Venugopalan, Ramakrishna
Autofluorescence Lifetime Measurement on Oral
CarcinogenesisChang, Chia-Lin; You, Chun; Chen, Hsin-Ming;Chiang, Chun-Pin; Chen, Chin-Tin; Wang, Chih-
Yu
Continuous Wave Doppler Methods to DialysisAccess MonitoringMolina, Paulo S. C.
Water Vapour Partial Pressure Control in
Neonatal Incubator Using Prevision by MultipleModels
Amorim, Mardson F.; Oliveira, Gustavo H. C;Silva, D.; Kiapuchinski, L.
Characteristic Properties ofImplantableAg/AgCI- and Pt-electrodes
Riistama, Jarno; Lekkala, Jukka
Development Stress Monitoring System Based on
Personal Digital Assistant (PDA)Lee, Mi-hee
2337
2341
2345
2349
2352
2356
2360
2364
Session 3.7.7: Data Acquisition Systems
Measuring Bioimpedance in the Human Uterine
Cervix: Towards Early Detection ofPreterm Labor
Hoe, Yen Shi Gillian; Gurewilsch, Edith D.;Shaahinfar, Ashkon; Hu, Elbert S.;
Sampattavanich, Somponnat; Ruffner, Melanie;
Ching, Kenny H. S.; Allen, Robert H. 2368
XXX
An ECGElectrode-Mounted Heart Rate,Respiratory Rhythm, Posture and Behavior
Recording SystemYoshimura, Takahiro; Yonezawa, Yoshiharu;Maki, Hiromichi; Ogawa, Hidekuni;Ninomiya, Ishio; Caldwell, W. Morton 2373
The Electrically Non-contacting ECGMeasurement on the Toilet Seat Using the
Capacitively-coupled Insulated ElectrodesKim, Ko Keun; Lim, Yong Kyu; Park, KwangSuk 2375
Ambulatory Instrumentation Suitablefor Long-Term Monitoring ofCattle Health
Schoenig, Scott A.; Hildreth, Tammi S.; Nagl,Luke.; Erickson, Howard; Spire, Mark;Andresen, Daniel; Warren, Steve 2379
The ECG Measurement in the Bathtub Using the
Insulated Electrodes
Lim, Yong Kyu; Kim, Ko Keun; Park, KwangSuk 2383
Variable Frequency BioimpedanceInstrumentation
Tsunami, Daniel T.; McNames, James; Colbert,Agatha; Pearson, Sean; Hammerschlag, Richard 2386
Effect of UltrasoundExposure on SurfactantMicrobubbles
Soetanto, Kawan 2390
Track 3.8: Sensor Applications and
Uses
Session 3.8.1: Presence and
Cybersickness
Human Behavior and Egocentric SpatialPerception Contingent with Gravity Cue
Koga, Kazuo 2395
Effects of Virtual Body Motion on Visually-Induced Motion Sickness
Ujike, Hiroyasu; Yokoi, Takashi; Saida, Shinya 2399
Time-Varying Behavior ofMotion Vectors in
Vection-Induced Images InRelation to
Autonomic RegulationKiryu, Tohru; Yamada, Hiroshi; Jimbo, Masahiro;Bando, Takehiko 2403
Quantitative Evaluation ofthe Effect of Visually-InducedMotion Sickness Using Causal
Coherence Function between BloodPressure and
Heart Rate
Sugita, Norihiro; Yoshizawa, Makoto; Tanaka,Akira; Abe, Ken-ichi; Shigeru, Chiba;Yambe, Tomoyuki; Nitta, Sin-ichi 2407
Assessment ofEmotionalReaction Induced byVisualStimulation Based on Cross-Correlation
between Pulse Wave Transmission Time and
Heart Rate in the Mayer Wave-Band
Yoshizawa, Makoto 2411
Influence ofAttention andPredictive Visual Cueon Motion Perception andSickness in Immersive
Virtual Environment
Fujita, Kinya 2415
Session 3.8.2: New Sensor Development
Biomechanics ofCranialDynamicsDuring DailyLiving Activities
Long, Jason T.; Jannetto, Nicholas; Bakker, Sara;Smith, Stephen; Harris, Gerald F.
MEMSShear Stress Sensorfor Cardiovascular
DiagnosticsSoundararajan, Gopikrishnan; Hsiai, Tzung K.;DeMaio, Lucas
Analysis ofSurface Plasmon Resonance Data
Using a PartialLeast Square Regression Methodfor Glucose Concentration Estimation
Chu, L. H.; Zhang, Y. T.; Zhang, C.
The Design and Fabrication ofTwo-DimensionMulti-Electrodes Array Chip and SystemChen, Jian-Ming; Huang, Jhen-Gang; Lin, Chii-
Wann
Pressure Sensorsfor In Vivo Measurements on
Spinal Growth Plates
Sauser, FrankE.; Glos, D.; Bylski-Austrow, D.;Papautsky, Ian
2417
2420
2424
2426
2430
Session 3.8.3: Advances in Design and
Application of Sensor Technology!
Importance ofSkin Resistance in the Reverse
Iontophoresis-basedKim, Dong Woo; Kim, Hong Seok; Lee, DongHoon; Kim, Hee Chan
A New Position Measurement Systemfor Micro-Measurements in OrthopaedicsDiSilvestro, Mark R; Sherman, Jason C; Dietz,Terry L.
Validation ofFour MajorAlgorithmsforEstimating the Instantaneous Helical Axis with
Miniature Triaxial GyroscopeRachid, Aissaoui
Quantification ofPre-parturition Restlessness in
CratedSows Using Ultrasonic Measurement
Huang, Y. S.; Huang, Y. P.; Wang, J. S.; Wu, M.
C; Young, M. S.
A sEMG-based MethodforAssessing the DesignofComputer Mice
Agarabi, Mina; Bonato, Paolo; De Luca, C, J.
2434
2438
2442
2446
2450
xxxi
Diamond-Like Carbon Coating on MicropipettesKakuta, Naoto; Okuyama, Naoki; Watanabe,
Mayu; Imai, Yuka; Mabuchi, Kunihiko; Yamada,Yukio 2454
A New Semiconductor Lithotripsy Sensor
Singh, V.R. 2458
Material Identification Using Real andSimulatedThermal Cues
Ho, Hsin-Ni; Jones, L. A. 2462
Session 3.8.4: Advances in Design and
Application of Sensor Technology II
VibrationAbsorbing Bracefor Study of Work-Related Upper Extremity Musculoskeletal
Disorders
Pottenger, Michael; Benhaim, Prosper
SystemDesignfor a Pediatric Physical TherapyStrength Testing Glove
Hooker, Josh; Barhorst, Craig; Brausen, Joe;Devlin, Jamie; Ford, Ethan; Bailey-Van Kuren,Michael
PhysiologicalInvestigation ofAutomobileDriver's Activation Index Using SimulatedMonotonousDrivingYamakoshi, Takehiro; Yamakoshi, Ken-ichi;Tanaka, Shinobu; Nogawa, Masamichi;Kusakabe, Masahiro; Kusumi, Masashi; Tanida,Kouji
in Unobtrusive In-home Monitoring Systemfordetection ofKey Motor Changes PrecedingCognitive Decline
Hayes, Tamara L.; Pavel, Misha; Kaye, Jeffrey A,
Postural Balance Indicator andAssociated
Feedback Compensation SystemIngerson, Paul G.
A Real-Time Blood Cross-Matching SensorforIntelligentManagement ofTransfusion SafetyRamasubramanian, M. K.; Anthony, Steven R.
Track 3.9: Thermal Therapy
Session 3.9.1: Advances in Thermal
Therapy I
Evaluation ofEndorectal and Urethral CoolingDevices during MR-Guided Ultrasound Thermal
Ablation in Canine Prostate
Nau, W. E; Diederich, C. J.; Ross, A. B.; Rieke,V.; Butts, K.; Sommers, G.
2466
2470
2476
2480
2484
2488
2492
Interstitial UltrasoundApplicators with DynamicAngular Controlfor ThermalAblation ofTumorsUnder MR-Guidance
Kinsey, Adam M.; Tyreus, Per Daniel; Rieke,Viola; Butts, Kim; Nau, William H.;Sommer, Graham; Diederich, Chris J. 2496
MRI-Temperature Mapping during UltrasoundProstate Ablation Using FatforPhaseEstimation
Rieke, Viola; Ross, Anthony B.; Nau, William H.;Diederich, Chris J.; Sommer, Graham; Butts, Kim 2500
A Devicefor Radiofrequency Assisted HepaticResection
Haemmerich, Dieter; Schutt, David J.; Will, James
A.; Striegel, Roberta M.;Webster, John G.; Mahvi, David M. 2503
Investigation ofMedical Thermal Treatment
Using a Hybrid Bio-Heat ModelWren, Joakim; Loyd, Dan; Karlsson, Marts 2507
Comparison Between a Detailed and a SimplifiedFinite ElementModel ofRadio-FrequencyLesioning in the Brain
Johansson, Johannes D.; Wren, Joakim; Loyd,Dan; Wardell, Karin 2510
Session 3.9.2: Advances in Thermal
Therapy II
Combination Applicatorfor Simultaneous HeatandRadiation
Stauffer, P. R.; Schlorff, J. L.; Taschereau, R.;Juang, T.; Neuman, D. G.; Maccarini, P. F.;Pouliot, J.; Hsu, I. C. 2514
Optimization ofa Dual Concentric ConductorAntennafor Superficial HyperthermiaApplicationsMaccarini, Paolo F.; Rolfsnes, Hans-Olav;Neuman, Daniel; Stauffer, Paul 2518
Design ofSpiralAntennasforRadiometricTemperature MeasurementRolfsnes, Hans Olav; Maccarini, Paolo; Jacobsen,Svein; Stauffer, Paul 2522
Coaxial-SlotAntennafor Interstitial MicrowaveThermal Therapy and ItsApplication to
Clinical Trial
Ito, Koichi; Saito, Kazuyuki; Yoshimura,Hiroyuki; Aoyagi, Yulaka; Horita, Hirotoshi 2526
IncreasedAcoustic and Electromagnetic EnergyDeposition in a Layered Tissue Model
Razansky, Daniel; Einziger, Pinchas D.; Adam,Dan R. 2530
rt'vVvV i'f'
Theme 4. Micro and Nano
Biotechnology
Track 4.1: Micro and Nano-Sensors for
Integrated Biotechnology: Electrical
Detection and Manipulation of SingleCells and Biomolecules
Session 4.1.1: Electrical and OpticalInterrogation Devices
Cell-Lab on a Chip: a CMOS-BasedMicrosystemfor Culturing and Monitoring Cells
Liu, Yingkai; Smela, Elisabeth; Nelson, Nicole
M.; Abshire, Pamela 2534
Optical Measurement ofTorsionalSpringModulus ofa Double-Stranded DNA Using
Half-CoatedNanoparticlesChoi, Jaehyuck; Zhao, Kai; Heller, Michael; Lo,Y.-H. 2538
Development ofBiocompatible NeurocagesTooker, Angela C; Meng, Ellis; Erickson, Jon;
Tai, Yu-Chong; Pine, Jerry 2542
Development ofa Multifunctional PlatformforExtra- and Intracellular IonicActivities
RecordingGuenat, Olivier T.; Boulard, Gaetan; Dufour, Jean-
Francois; de Rooij, Nico; Koudelka-Hep, Mlena 2546
Effects ofScaling on theSNR and Speed ofBiosensors
Hassibi, Arjang; Lee, Thomas H.; Navid, Reza;Dutton, Robert W.; Zahedi, Sina 2549
Surface Plasmon Resonance BiochipsforTuberculosis Bacillus
Huang, Jhen-Gang; Hung, Chi-Chan K.; Lai, Hsin-
Chih; Lee, Chih-Kung; Lin, Shi-Ming;Feng, Ping; Lin, Chii-Wann 2553
Electrical Detection ofthe Contact between a
Microinjection Pipette and Cells
Lukkari, Mikko J.; Karjalainen, Mikko I.;Sarkanen, Riina; Linne, Marja-Leena;Jalonen, Tuula O.; Kallio, Pasi J. 2557
Track 4.2: Micro/Nano Cytometry:Sorting of Cells/Biomolecules
Session 4.2.1: Manipulation of Cells on
Chips I
Hybrid Polymer/Thin Film Impedance SystemforLabelFree Monitoring ofCells
Mohanty, Swomitra K.; Sohn, Lydia L.; Beebe,David J. 2561
Biochemical, Biomolecular and Cellular Sensingin Microfluidics Using Flow InducedAdmittanceSpectraCollins, J.; Flanagan, L.; Jeon, N.; Monuki, E.;Lee, A. P. 2565
BiologicalSensing with an On-Chip Resistive
Pulse AnalyzerSaleh, Omar A.; Sohn, Lydia L. 2568
High-Throughput CellManipulation UsingUltrasound Fields
Kim, Deok-Ho; Haake, Albrecht; Sun, Yu;Neild,Adrian P.; Dim, Jong-Eun; Dual, Jurg;Hubbell, Jeffrey A.; Ju, Byeong-kwon; Nelson,Bradley J. 2571
Droplet-basedMagnetically Activated Cell
SeparationKim, Young Ho; Hong, Su; Kim, Byung Kyu;Yun, Seok; Kang, Yu Ri; Paek, Kyeong Kap;Lee, Jin Woo; Lee, Sang Ho; Ju, Byeong Kwon 2575
Session 4.2.2: Manipulation of Cells on
Chips II
MEMS-BasedFlow Cytometry: Microfluidics-Based CellIdentification System byFluorescentImagingWu, W.K.; Liang, C.K.; Huang, J. Z. 2579
Nanomanipulatlon and Characterization ofStructuralProteins
Layton, Bradley E.; Gupta, Rishi; Jackson, NykiaL.; Shah, Aditya J.; Stallcup, HI, Richard E.;
Sullivan, Stephanie M. 2582
Cytometry Microchip UsingPolymer-basedSaltbridge Electrodes
Chun, Honggu; Chung, Taek Dong; Kim, Hee
Chan 2584
Finite ElementModelling ofa 3 Dimensional
Dielectrophoretic Flow SeparatorDeviceforOptimal Bioprocessing Conditions
Fatoyinbo, Henry 0.; Hughes, Michael P. 2587
Track 4.3: Hybrid Devices IntegratingCell Machinery and Micro/Nano
Sensors
Session 4.3.1: Molecular Motors and
Biomolecules Hybrid to Chips
Novel Micro Gripping, Probing, andSensingDevicesfor Single CellSurgeryLi,WenJ.;Xi,Ning 2591
Flagellar Motor BasedMicro HybridDevices
Tung, Steve; Kim, Jin-Woo 2595
xxxiii
RETNanobiosensors using Affinity ofan Apo-Enzyme Toward its Substrate
Chinnayelka, Swetha; McShane, Michael J. 2599
Shape Recovering ofLive Endothelial Cell under
Atomic Force Microscopy Imaging
Shen, Yi; Sun, Jielin; Zhang, Aili; Hu, Jun; Xu,
LisaX. 2603
Development ofa MEMSMicrosystem to Studythe Effect ofMechanical Tension on Cerebral
Cortex NeurogenesisLin, Gisela; Wu, Vincent I.; Hainley, Ryan E.;
Flanagan, LisaA.; Monuki, Edwin S.; Tang,William C. 2607
Track 4.5: Lab-On-A-Chip for Sample
Preparation
Session 4.5.1: Micro and Nano Separation
Techniques I
Biomolecule Separation by Steric Hindrance
usingNanofluidic Filters
Han, Jongyoon; Fu, Jianping 2611
Microfluidic System Integration in Sample
Preparation Chip-Sets - a SummaryGrodzinski, Piotr; Liu, R.; Yang, J.; Ward, M. D. 2615
Microfabricated Templatesfor the
Electrodeposition ofMetallic Barcodesfor Use in
Multiplexed BioassaysTrue, Randall J. 2619
Control ofConcentration and Volume Gradients
in Microfluidic DropletArraysforProtein
Crystallization ScreeningChao, Wen-Chi; Collins, John; Wang, Szu-Wen;
Li, G. P.; Bachman, Mark; Lee, Abraham P. 2623
Separation ofBlood in MicroChannel Bends
Blattert, Christoph; Jurischka, Reinhold; Tahhan,
Isam; Schoth, Andreas; Kerth, Paul; Menz,
Wolfgang 2627
High SpeedParticles Separation UsingUltrasoundfor Micro-TAS and Lab-On-A-Chip
ApplicationLi,HoIden 2631
Session 4.5.2: Micro and Nano SeparationTechniques II
An Examination ofthe Effect of an AC Pulsed
Electric Fieldon Cell Mortality in
SWLA-2 HybridomasGross, Brooks A.; Kandlikar, Sachin S.; Oakley,Barbara A.; Hanna, Darrin M.;Rusek, Andrew; Stryker, Gabrielle A. 2635
2647
2650
A Magnetically Driven PDMS Peristaltic
MicropumpPan, Tingrui; Kai, Eleanor; Stay, Matthew;Barocas, Victor; Ziaie, Babak 2639
An Examination ofthe Effect ofDecaying
ExponentialPulse Electric Fields on Cell
Mortality in Murine Spleenocytes, Hybridomas,andHuman Natural Killer Cells
Kandlikar, Sachin S.; Oakley, Barbara A.; Hanna,Darrin M.; Stryker, Gabrielle A. 2643
Quantitative and Qualitative Analyses ofDNAFragments Based on Electrical ChargeDetection
on a Portable Electrophoresis Device
Chen, Gin Shin, Chen, Sheng Fu, Lu, Chih Cheng
A Magnetically Driven PDMS Micropump with
Micro-Ball Valves
McDonald, Scott J.; Pan, Tingrui; Ziaie, Babak
Track 4.6: Drug Delivery by Micro &
Nano Technology
Session 4.6.1: Drug Delivery Chips
BiodegradablePolymerMicroneedles:
Fabrication, Mechanics and TransdermalDrugDeliveryPark, Jung-Hwan; Allen, M. G.; Prausnitz, M, R. 2654
Remotely Adjustable Check-Valves with an
Electrochemical Release Mechanismfor
Implantable Biomedical MicrosystemPan, Tingrui; Balti, Antonio; Ziaie, Babak 2658
Real Time 3D Detection ofNanoparticleLiposomes Extravasation Using Laser
Confocal MicroscopyLiu, Ping; Zhang, Aili; Zhou, Mingjie; Xu,
Yuhong; Xu, Lisa X. 2662
In Vivo Transfection MicrosystemsRivera, Florence; Berthier, Jean; Cochet, Marline;Caillat, Patrice; Berger, Francois 2666
Implantable Microchipsfor ControlledDrug
DeliverySantini, Jr., John T.; Maloney, John M. 2668
Hydrogel-Based BioMEMS Platformsfor Smart
Drug DeliveryZiaie, Babak; Siegel, Ronald A. 2670
jorjriv
Track 4.7: Micro/Nanotechnology for
Tissue Engineering Applications
Session 4.7.1: Tissue Engineering on
Chips
CellAdhesion Testing using Novel Testbeds
Containing Micropatterns ofComplexNanoengineeredMultilayer FilmsShaikh-Mohammed, J.; DeCoster, M. A.;
McShane, Michael J. 2671
Long-term Micropatterned Cell Cultures in
Heterogeneous Microfluidic Environments
Tourovskaia, Anna; Folch, Albert; Figueroa-Masot, Xavier 2675
Real Three-Dimensional MicrofabricationforBiodegradable Polymers -Demonstration ofHigh-Resolution and BiocompatibilityforImplantable MicrodevicesBcuta, Koji; Yamada, Akira; Niikura, Fuminori 2679
Electrolytically Generated Oxygen
Microgradientsfor Cell Culture
Park, Jaehyun; Bansal, Tushar; Maharbiz, Michel
M. 2683
Theme 5. Biorobotics and
Biomechatronics
Track 5.1: Bio-Sensors for Robotic
Applications
Session 5.1.1: Rehabilitative Robotics I
Robotic Assessment ofLocomotor Recovery in
Spinal Contused Rats
Nessler, J. A.; Reinkensmeyer, D. J.; Sharp, K.;Kwak,E.;Minakata,K.;DeLeon,R. D, 2687
Passive Derivation ofBasic Walker-Assisted Gait
Characteristicsfrom Measured Forces
andMoments
Alwan, M.; Wasson, G.; Sheth, P.; Ledoux, A.;Huang, C. 2691
Gravity Balancing Rehabilitative Robotfor the
Human LegsFattah, Abbas; Agrawal, Sunil K. 2695
Virtual Walkway System and Prediction ofGaitMode Transitionfor the Control oftheGait Simulator
Shiozawa, Naruhiro; Arima, Syuichi; Makikawa,Masaaki 2699
Safety Conceptfor Robotic Gait Trainers
Schmidt, Henning; Hesse, Stefan; Bernhardt, Rolf
2703
ExperimentalDemonstration ofanActuatedExercise Machine
Zhang, X. T.; Dawson, D. M.; Dixon, W. E.; Xian,B. 2707
Session 5.1.2: Rehabilitative Robotics II
A Pneumatic MuscleHand Therapy DeviceKoeneman, E. J.; Schultz, R, S.; Wolf, S. L.;Herring, D. E.; Koeneman, J. B. 2711
Exoskeletonfor Forearm Pronation/SuppinationRehabilitation
Andreasen, D. S.; Allen, S. K; Aviles, A. A.;Jennings, B. R; Guthrie, K.B; Sprigle, S. H. 2714
Utilization ofBiomechanical Modeling in DesignofRoboticArmfor Rehabilitation of
StrokePatients
Huang, He; He, Jiping 2718
Adaptive Assistancefor Guided Force Trainingin Chronic Stroke
Kahn, Leonard E.; Rymer, W. Zev;Reinkensmeyer, David J. 2722
Spring Over Muscle (SOM) ActuatorforRehabilitation Devices
Bharadwaj, Kartik; Hollander, Kevin W.; Mathis,Christian A.; Sugar, Thomas G. 2726
Track 5.2: Intelligent Robotic Control
Session 5.2.1: Surgical Robotics
Trajectory GenerationforRoboticNeedleInsertion in Soft TissueAbolhassani, Niki; Patel, Rajni; Moallem,Mehrdad
Static and Dynamic Accuracy ofVitreoretinalSurgeonsPeral-Gutierrez, F.; Liao, A. L.; Riviere, C. N.
2730
2734
Active Tremor Compensation in MicrosurgeryAng, Wei Tech; Khosla, Pradeep; Riviere,Cameron 2738
Robotic Controlin Hand-AssistedLaparoscopicNephrectomy in Humans - a PilotStudyChatzilias, Peter; Kamarianakis, Zaxarias;Golemati, Spyretta; Christodoulou, Manolis 2742
A Haptic Guidance Toolfor CT-Directed
Percutaneous Interventions
Hagmann, Emmanuel; Rouiller, Patrice; Helmer,Patrick; Grange, Sebastien; Baur, Charles 2746
An Er: YAG Laser Bone Cutting ManipulatorforPrecise Rotational Acetabular OsteotomyKim, Daeyoung; Owada, Hideaki; Hata,Nobuhiko; Dohi, Takeyoshi 2750
XXXV
Track 5.3: Micro and Nano Robots
Session 5.3.1: Robotics in Biomedical
Applications
Determining Deformation Resistance in CuttingSoft Tissue with Non-Uniform Thickness
Chanthasopeephan, Teeranoot; Desai, Jaydev P.;Lau,AlanC.W. 2754
Soft-Tissue Material Properties under LargeDeformation: Strain Rate EffectHu, Tie; Desai, Jaydev P. 2758
Simulating ComplicatedHuman BirthforResearch and TrainingKim, Esther J.; Allen, Robert H.; Yang, Jason H.;McDonald, Mary K.;Tarn, William; Gurewitsch, Edith D. 2762
Locomotion ofaLegged Capsule in the
Gastrointestinal Tract: Theoretical Study and
Preliminary Technological Results
Menciassi, Arianna; Stefanini, Cesare; Gorini,Samuele; Pernorio, Giuseppe; Kim, Byungkyu;Park, Jong-Oh; Dario, Paolo 2767
AppliedForce during Vitreoretinal Microsurgerywith HandheldInstruments
Jagtap, Anirudha D.; Riviere, Cameron N. 2771
A Study on Implantable Urination Assist Systems-Development ofa Bladder Compression SystemKiguchi, Kazuo 2774
Theme 6. Bioinformatics and
Computational Biology
Track 6.1: Algorithm and Software
System for Bioinformatics
Session 6.1.1: Algorithm & Software
System for Bioinformatics
The BlastNP: A Novel, Sensitive SequenceSimilarity Searching Method usingOverlappingly Translated SequencesBiro, Jan C; Biro, Josephine M.K. 2777
Order Independent StructuralAlignment ofCircularly PermutedProteinsBinkowski, T. Andrew; DasGupta, Bhaskar;Liang, Jie 2781
Corpus Based Learning ofStochastic Context-Free Grammar Combined with Hidden MarkovModelsfor TRNA ModellingGarcia-Gomez, Juan M.; Benedi, Jose M. 2785
Globally Optimal Classification and Pairing ofHuman Chromosomes
Wu, Xiaolin; Biyani, Pravesh; Dumitrescu, Sorina;Wu, Qiang 2789
Finding the Best Ridge Regression Subset ByGenetic Algorithms:Applications to Multi-Locus
Quantitative Trait MappingZhang, Bin; Horvath, Steve 2793
A Software Systemfor Gene Sequence Database
Construction
Liu, Zheng; Borneman, James; Jiang, Tao 2797
Session 6.1.2: Bioinformatics for
Understanding Genes, Transcripts andProteins
An InterpolatedMarkov Model Polishes Gibbs
Sampling's Ability in DetectingRegulatory Elements
Ying, Xie X.; Sun, Xiao; Ming, Xie J.; Hong, LuZu 2801
A Three-Layer Multi-Database SystemforFunctional StatisticalAnalyses ofMicroarrayExperiment Results
Masseroli, Marco; Martucci, Dario; Pinciroli,Francesco 2805
EGOMiner: A Comprehensive Genomics and
Proteomics Data Analysis and BiologicalFunction Interpretation SystemFeng, Weimin; Henning, Peter; Wang, May D. 2809
A General Probabilistic Model ofthe PCRProcess
Saha, Nilanjan; Watson, Layne T.; Kafader,Karen; Onufriev, Alexy; Ramakrishnan, Naren;Vasquez-Robinet, Cecilia; Watkinson, Jonathan 2813
A Parallel Implementation of the Smith-Waterman Algorithmfor Massive SequencesSearchingLiao, Hsien-Yu; Yin, Meng-Lai; Cheng, Yi 2817
Identifying Gene Ontology Concepts in Natural-
Language Text
Crangle, Colleen E.; Zbyslaw, A. 2821
Track 6.2: Computational Genomics
and Proteomics
Session 6.2.1: Computational Genomicsand Proteomics I
The Search for the Optimal Ribosome 3' Tail
EndinEcoli
Ponnala, L.; Barnes, T. M.; Bitzer, D. L.; Vouk,M. A. 2824
xxxvi
OptimalNonlinear Scoring Functionfor Global
Fitness Landscape ofProtein DesignHu, Changyu; Li, Xiang; Liang, Jie 2828
Representability ofGenomic SignalsCristea,PaulDanA. 2832
Splice Site Detection using PrunedMaximumLikelihood Model
Lai, Anuradha; Radhakrishnan, Srirekha; Srinivas,Shiva S.;Najarian, Kayvan; Mays, Larry E. 2836
Linear Reduction Methodsfor Tag SNP
Selection
He, Jingwu; Zelikovsky, Alex 2840
Building Phylogenetic Treesfrom BinaryOligonucleotide Fingerprint Vectors
Figueroa, Andres; Liu, Z.; Mancini-Jones, R;Borneman, J.; Jiang, T. 2844
Session 6.2.2: Computational Genomicsand Proteomics II
Free Energy Periodicity InProkaryotic Codingand its Role in Identification of+1 Ribosomal
Frameshifting in the Escherichia ColiK-12 Gene
prfBMishra, M.; Vu, S. K.; Bitzer, D. L.; Vouk, M. A.
Automatic Segmentation ofDNA Bands in One
Dimensional GelImages Produced byHybridizing TechniquesAkbari, Akbar; Albregtsen, Fritz
Improvement ofTRANSFACMatrices UsingMultiple LocalAlignment ofTranscriptionFactor Binding Site SequencesFu, Yutao; Weng, Zhiping
Codes in the Codons: Construction ofaCodon/Amino AcidPeriodic Table and a Study ofthe Nature ofSpecific Nucleic Acid - Protein
Interactions
Benyo, Balazs; Biro, Jan C; Benyo, Zoltan
Accelerating Phylogenetics Computing on the
Desktop: Experiments with UPGMA
Davis, James P.; Akella, Sreesa; Waddell, Peter J.
RNAMAT:An Efficient Method to Detect Classes
ofRNA Molecules
Horesh, Yair; Amir, Amihood; Michaeli,
Shulamit; Unger, Ron
2848
2852
2856
2860
2864
2869
Track 6.3: Regulatory Elements, GeneNetworks and Simulation of Cell
Session 6.3.1: Regulatory Elements,Regulatory Networks and Protein
Structures I
Consequences ofDeterministic andStochastic
Modeling ofa Promoter
Zhou, Zhan Huan; Davies, Stephen W. 2873
Synthetic Gene Oscillators by Negative FeedbackNetworks
Wang, Ruiqi; Zhou, Tianshou; Chen, Luonan 2877
Cellular Function Prediction andBiologicalPathway Discovery in Arabidopsis thaliana UsingMicroarray Data
Joshi, Trupti; Chen, Yu; Alexandrov, Nickolai;Xu, Dong 2881
Kernel BasedApproachforProtein FoldPredictionfrom SequenceLanglois, Robert E.; Diec, Alice; Dai, Yang; Lu,Hui 2885
Prediction ofProtein SolventProfile Using SVR
Yuan, Zheng; Bailey, Timothy L. 2889
Estimation ofProtein Secondary StructurefromSynchrotron Radiation Circular
Dichroism SpectraProcopiou, Andreas; Allinson, Nigel; Jones,Gareth; Clarke, David 2893
Session 6.3.2: Regulatory Elements,Regulatory Networks and Protein
Structures II
Modeling of The Suprachiasmatic Nucleus Basedon ReducedMolecular Clock Mechanisms
Nakao, Mitsuyuki; Nishimura, Yoshinari; Aoki,Kazufumi; Katayama, Norihiro 2897
Analysis ofthe Transforming Growth Factor-
Betal Pathway and Extracellular Matrix
Formation as a Hybrid SystemMusters, Mark W. J. M.; van Riel, Natal A. W. 2901
Inference ofGenetic Regulatory Networks with
Recurrent Neural NetworkModels
Xu, Rui; Hu, Xiao; Wunsch, Donald C. 2905
Parameter Optimization Technique Using The
Response Surface MethodologyKoyamada, Koji; Sakai, Koji; Itoh, Takayuki 2909
Dynamic Pathway Modeling ofSphingolipidMetabolism
Henning, Peter; Merrill, Alfred; Wang, May D. 2913
xxxvii
Automated Characterization ofGene Expression
Patterns with anAtlas oftheMouse Brain
Carson, James P.; Ju, Tao; Thaller, Christina;
Warren, Joe; Bello, Musodiq;Kakadiaris, Ioannis; Chiu, Wah; Eichele, Gregor 2917
Track 6.4: Gene Expression and
Micorarray Analysis
Session 6.4.1: Gene Expression and
Microarray Analysis I
A NovelStepwise Normalization MethodforTwo-Channel cDNA MicroarraysXiao, Yuanyuan; Hunt, C. Anthony; Segal, Mark
R.;Yang,YeeH. 2921
An Application ofZero-suppressed BinaryDecision Diagrams to ClusteringAnalysis ofDNA Microarray Data
Yoon, Sungroh; De Micheli, Giovanni 2925
A New Distance Measurementfor ClusteringTime-Course Gene Expression Data
Chen, Guanrao; Dai, Yang 2929
A Bayesian Approach to Expression Network
ComponentAnalysisSabatti, Chiara; Rohlin, Lars 2933
Network Component Analysis ofSaccharamycescerevisiae Stress ResponseLiao, James C; Yang, Young-Lyeol 2937
Discovering Dynamic Regulatory Pathway by
Applying an Auto Regressive Model to Time
Series DNA Microarray Data
Darvish, Alireza; Hakimzadeh, R.; Najarian,Kayvan 2941
Session 6.4.2: Gene Expression and
Microarray Analysis II
Genetic Data Acquirement, Construction and
Analysis Based on Microarray TechnologyHong, Lu Zu 2945
Association ofBeta-Adrenoceptor SingleNucleotide Polymorphisms with Resting HeartRate
Xie, Zheng Xiang; Niu,Yong Hong; Ma, Hou Xun;Yin, Yue Hui; Liu, Zeng Zhang; Li, Zhang Yong 2948
Using Multi-Agent Systemfor Gene ExpressionClassificationStiglic, Gregor; Kokol, Peter 2952
A DNA-basedPattern Recognition TechniqueforCancerDetection
Peterson, David J.; Lee, Charles H. 2956
Comparative Study ofMicroarray DataforCancer Research
Phan, John H.; Quo, Chang F.; Wang, May D. 2960
Track 6.5: Structural and Functional
Bioinformatics
Session 6.5.1: Structural and Functional
Bioinformatics I
Protein Secondary Structure Prediction with
Semi Markov HMMs
Aydin, Zafer; Altunbasak, Yucel; Borodovsky,Mark
Parallel Protein Secondary Structure Prediction
Based on NeuralNetwork
Zhong, Wei; Altun, Gulsah; Tian, Xinmin;
Harrison, Robert; Tai, Phang C; Pan, Yi
A Bipartite Graph Matching FrameworkforFinding Correspondences between Structural
Elements in Two Proteins
Wang, Yuhang; Makedon, Fillia; Ford, James;
Huang, Heng
Potential Function ofSimplified Protein Models
for Discriminating Native Proteinsfrom Decoys:Combining Contact Interaction and Local
Sequence-Dependent GeometryZhang, Jinfeng; Chen, Rong; Liang, Jie
Computational Prediction ofBinding HotspotsTong, Weiwei; Li, L.; Weng, Zhiping
2964
2968
2972
2976
2980
Session 6.5.2: Structural and Functional
Bioinformatics II
Linking Molecular Function and BiologicalProcess Terms in the Gene Ontologyfor Gene
Expression Data AnalysisDeJongh, Matthew; Van Dort, Pamela; Ramsay,Benjamin 2984
Protein Secondary Structure Prediction usingNeuralNetwork andSimulatedAnnealing
AlgorithmAkkaladevi, Somasheker; Katangur, Ajay K.;Belkasim, Saeid; Pan, Yi
PRISM: Protein Integration ofSequence Metrics
Addison, Edwin R.
Comparison ofSkin Resistance between
Biological Active Points ofLeft and Right handswith various Contact Pressures
Fang, Qiang; Bedi, Raji; Ahmed, Becna; Cosic,Irena
Clustering Protein-Protein Docking Predictions
Tong, Weiwei; Weng, Zhiping
2987
2991
2995
2999
xxxviii
Binding Modes of Two Highly Potent andNon¬
toxic Inhibitors ofHIV-1 IntegraseZhu, Hai Mei; Chen, Wei Zu; Wang, Cun Xin 3003
A CentralPartition ofMolecular Conformational
Space. II. Embedding 3D Structures
Gabarro-Arpa, Jacques 3007
Knowledge-BasedAlgorithmsfor Chemical
Structure andProperty AnalysisVolarath, Patra; Wang, Hao; Fu, Haihua; Harrison,Robert 3011
Track 6.6: Novel Technologies for
Computational Biology andBioinformatics
Session 6.6.1: Novel Technologies for
Computational Biology andBioinformatics I
Maximum a Posteriori (MAP) Estimatorfor
Polymerase Chain Reaction (PCR) Processes
Kakavand, Hossein 3015
Domain Specific Languagesfor Cellular
Interactions
Harrison, William; Harrison, Robert 3019
Biodynamic Modeling andSimulation ofMulti¬
stage CarcinogenesisAhangar, Reza; Iqbal, Kamran 3023
Computationally Efficient Cardiac BioelectricityModels Toward Whole-Heart Simulation
Wedge, Nathan A.; Branicky, Michael S.;
Cavusoglu, M. Cenk 3027
Bayesian Networks ofBI-RADSDescriptors ofBreast Lesions
Fischer, Ernest; Lo, Joseph; Markey, Mia K. 3031
The Genetic Profile ofa Tumor as aDeterminant
ofIts Response to Radiotherapy: A ComputerSimulation ofTwo DifferentRadiotherapeuticSchemes
Dionysiou, Dimitra D.; Peristeris, T.; Stamatakos,
Georgios S.;Nikita, Konstantina S.; Uzunoglu, Nikolaos K. 3035
Session 6.6.2: Novel Technologies for
Computational Biology andBioinformatics II
Stochastic Modeling and Validation ofGrowth
Saturation and Radiotherapeutic Response of
Multicellular Tumor SpheroidsZacharaki, E. I.; Stamatakos, G. S.; Nikita, K. S.;Uzunoglu, N.K. 3039
DNA SequenceMatchingProcessor Using FPGAand JAVA InterfaceBrown, Ben; Yin, Meng-Lai; Cheng, Yi 3043
A Software Environmentfor Simulators Suitable
for Complex Biological AnalysisShimayoshi, Takao; Hori, Kenta; Lu, JianYin;Amano, Akira; Matsuda, Tetsuya 3047
Track 6.7: Computational Methods
Session 6.7.1: Computational Methods for
Proteomics
StatisticalAssessmentfor Mass-spec Protein
Identification Using Peptide FingerprintingApproachGanapathy, Ashwin; Wan,Xiu-Feng; Wan,Jinrong; Thelen, Jay; Emerich, David W.;
Stacey, Gary; Xu, Dong 3051
Modeling Protein Tandem Mass SpectrometryData withAn ExtendedLinearRegression
StrategyLiu, Han; Bonner, Anthony; Emili, Andrew 3055
Reducing the Cost ofProtein IdentificationsfromMass Spectrometry Databases
Logan, Beth T.; Kontothanassis, Leonidas;Goddeau, David; Moreno, Pedro;Hookway, Ray; Sarracmo, David 3060
Protein Seer: A Web ServerforProtein
Homology Detection
Logan, Beth T.; Karaoz, Ulas; Moreno, Pedro;
Weng, Zhiping; Kasif, Simon 3064
Analysis andRobot PipelinedAutomationforSELDI-TOFMass SpectrometryAlterovitz, Gil; Aivado, Manuel; Spentzos,Dimitrios; Libermann, Towia A.;Ramoni, Marco; Kohane, Isaac S. 3068
Theme 7. Healthcare Information
Technology
Track 7,1: Telemedicine Technology
Session 7.1.1: Telemedicine TechnologyandDeployment I
Modeling Telehealth and Telemedicine:A Global
GeosociopoliticalPerspectiveStamm, B. Hudnall 3072
Improving Heart Failure Care by Using a
Telemedicine SystemSantamore, William P.; Homko, Carol; Marble,
Judith; Wald, Joyce; Bove, Alfred A. 3076
xxxix
3093
A Novel Mobile Telemedicine SystemforAmbulance Transport. Design and Evaluation
Mandellos, G. J.; Lymberopoulos, D. K.; Koukias,M. N.; Tzes, A.; Lazarou, N.; Vagianos, C. 3080
Using Telehealth Technology to Improve the
Delivery ofHealth Services to People who are
DeafHughes, Glen; Hudgins, Bernard; MacDougall,James 3084
Networking Technology and Health Care in
Eastern North Carolina
Brinn,JackE. 3088
Establishing a Rural Telehealth Project: the
WyomingNetworkfor Telehealth
Gantenbein, Rex E.; Cadez, Fran; Stamm, Beth
Hudnall 3089
Session 7.1.2: Telemedicine Technologyand Deployment II
Design ofan Interoperability Framework in a
Regional Healthcare SystemBerler, Alexander A.; Pavlopoulos, Sotiris;Koutsouris, Dimitris
Integration ofMonitoringDevices in the e-Vital
Service
Sakka, Eleni; Prentza, Andriana; Lamprinos, Ilias
E.; Leondaridis, Lefteris; Koutsouris, Dimitris
Bio-Stream: A System Architecturefor Real-
TimeProcessing ofPhysiological SignalsBar-Or, Amir; Goddeau, David M.; Healey,Jennifer A.; Kontothanassis, Leonidas; Logan,Beth;Nelson, Alex; Van Thong, Jean-Manuel
Using Handheld Devicesfor Real-Time Wireless
Teleconsultation
Banitsas, Konstantinos A.; Georgiadis, P.;
Tachakra, S.; Cavouras, D.
Design ofMultimedia Telemedicine SystemforInter-hospital ConsultationSun K. Yoo, Kwang M. Kim, Suck M. Jung,Kyung Joung Lee, Nam H. Kim
TM-Provider: a New Communicatory ModelforTelemedicine Services SupportKolovou, Lamprini T.; Triantafyllou, George N.;Chassomeris, Constantine A.;Karavatselou, Evy I.; Lymberopoulos, Dimitris K,
A Front-end Platform ofthe Network-based
Intelligent Home Healthcare Embedded SystemTang, Shuo; Chan, Weng Chi; Vai, Mang I.; Mak,Peng Un
3097
3101
3105
3109
3112
3116
Track 7.2: Virtual and AugmentedReality Technology in Healthcare
Session 7.2.1: Telesurgery and Virtual
Reality Technology in Healthcare I
Modeling Liver Physiology: Combining Fractals,Imaging andAnimation
Lin, Debbie 3120
Virtual Planning ofMulticatheter BrachytherapyImplantsfor Accelerated Partial
BreastIrradiation
Schmidt-Ullrich, P. N.; Todor, D. A.; Cuttino, L.
W.; Arthur, D. W. 3124
Linking Ontologies with Three-Dimensional
Models ofAnatomy to Predict the Effects ofPenetrating InjuriesRubin, Daniel L.; Bashir, Yasser; Grossman,David; Dev, Parvati; Musen, Mark A. 3128
A Novel Navigation Principle in Computer-AssistedSurgery
Buzug, Thorsten M.; Hering, Peter; Bongartz,Jens; Ivanenko, Michael 3132
Session 7.2.2: Telesurgery and Virtual
Reality Technology in Healthcare II
Content-Based Video Codingfor Remote
Monitoring ofNeurosurgeryXu, Jian; Ilgin, Hakki; Liu, Qiang; Kassam, Amin;Sclabassi, Robert J.; Chaparro, Luis F.; Sun,
Mingui 3136
Networked Interaction Therapy: Relieving Stress
in Memory-ImpairedPeople and Their
Family MembersKuwahara, Noriaki; Kuwabara, Kazuhiro; Utsumi,Akira; Yasuda, Kiyoshi; Tetsutani, Nobuji 3140
Identification ofLenke Spine DeformityClassification By Simplified 3D Spine ModelLin, Hong; Sucato, Dan 3144
Track 7.4: Electronic Health Records
and Medical Databases
Session 7.4.1: Electronic Health Records
and Medical Databases I
Personal Recognition using Head-Top ImageforHealth-Monitoring System in the Home
Nakajima, Kazuki; Sasaki, Kazuo 3147
A Home Health Monitoring System IncludingIntelligent Reporting and Alerts
Garsden, Hugh; Basilakis, Jim; Celler, Branko G.;
Huynh, Khang; Lovell, Nigel H. 3151
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