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Bolile autoimune.
Аутоиммунные болезни.
Autoimmune diseases.
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Tema:Bolile autoimune.
I. Micropreparate:
№ 125. Periarterită nodoasă (coloraţie H-E.). Indicaţii:
1. Peretele arterial îngroşat.
2. Infiltraţia limfo-macrofagală difuză localizată preponderent în adventiţie.
3. Lumenul stenozat al arterei.
№ 148. Tiroidita Hashimoto. (Coloraţie H-E.). Indicaţii:
1. Infiltraţia limfocitară a ţesutului glandei tiroide.
2. Foliculi limfatici.
3. Foliculi tiroidieni atrofiaţi cu coloid palid.
4. Foliculi tiroidieni nemodificaţi.
№ 21. Amiloidoza nodulară a splinei (splină sago). (coloraţie roşu de Congo şi hematoxilină). Indicaţii:
1. Depozite focale de amiloid în centrul foliculilor limfoizi.
2. Pulpa roșie adiacentă intactă
№ 19. Amiloidoza rinichiului. (coloraţie roşu de Congo şi hematoxilină). Indicaţii:
1. Depozite de amiloid:
a. în capilarele glomerulare;
b. în peretele arterelor;
c. pe membrana bazală a tubilor renali.
2. Cilindri proteici în lumenul tubilor.
II. Macropreparate:
№ 82. Amiloidoza rinichiului.
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Тема: Аутоиммунные болезни.
I. Микропрепараты:
№ 125. Узелковый периатрериит. (Oкраска Г-Э.). Обозначения:
1. Диффузное утолщение стенки артерии.
2. Лимфо-плазмоцитарная инфильтрация, локализованная преимущественно.
в наружной оболочке сосуда.
3. Суженный просвет сосуда.
№ 148. Тиреоидит Хашимото. (Окраска Г-Э.). Обозначения:
1. Лимфоидная инфильтрация ткани щитовидной железы.
2. Лимфоидные фолликулы.
3. Атрофированные железистые фолликулы с бледным коллоидом.
4. Нормальные железистые фолликулы.
№ 21. Нодулярный амилоидоз селезенки (саговая селезенка). (Oкраска конго-красным
и гематоксилином). Обозначения:
1. Очаговые отложения амилоидa в центре лимфоидных фолликулов.
2. Неизмененная красная пульпа.
№ 19. Амилоидоз почки. (Oкраска конго-красным и гематоксилином). Обозначения:
1. Отложения амилоида:
а. в капиллярах клубочка;
б. в стенках артерий;
в. в базальной мембране канальцев.
2. Белковые цилиндры в просвете канальцев
II. Мaкропрепараты:
№ 82. Амилоидоз почки.
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Autoimmune diseases.
I. Microspecimens:
№ 125. Periarteritis nodosa. (H-E. stain). Indications:
1. Thickened arterial wall.
2. Diffuse lymphocytic and macrophage infiltration located predominantly in adventitia.
3. Narrowed artery lumen.
№ 148 Hashimoto's thyroiditis. (H-E. stain). Indications:
1. Lymphocyte infiltration of the thyroid gland.
2. Lymphatic follicles.
3. Atrophied thyroid follicles with pale colloid.
4. Unchanged thyroid follicles.
№ 21. Focal spleen amyloidosis (sago spleen). (Congo-red and hematoxylin stain.). Indications:
1. Focal deposits of amyloid in the center of lymphoid follicles.
2. Unchanged red pulp.
№ 19. Renal amyloidosis. (Congo-red and hematoxylin stain.) Indications:
1. Amyloid deposits:
a. in glomerular capillaries;
b. in the artery wall;
c. on the basement membrane of the renal tubules.
2. Protein cylinders in tubule lumen.
II. Macrospecimens:
№ 82. Renal amyloidosis.
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Lupus eritematos sistemic (“figură de fluture”)
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Lupus eritematos discoid.
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Autoanticorpi antinucleari și
corpi hematoxilinici.
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Celulă lupică(leucocit neutrofil, care a fagocitat
un nucleu denaturat).
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Glomerulonefrită lupică.
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Glomerulonefrită lupică(capilare glomerulare cu aspect de ansă de sârmă).
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Glomerulonefrită lupică, microscopie fluorescentă cu
anticorpi contra IgG (aspect liniar al depozitelor de complexe imune).
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Scleroză “bulbară” periarterială în splină în LES.
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LES: endocardită Libman-
Sacks, vasculită.
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Artrită reumatoidă.
Mecanismul apariției panusului (țesutului de
granulație) pe membrana sinovială.
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Artrită reumatoidă.
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Nodul reumatoid. (H-E).
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Sclerodermie sistemică (îngroşarea pielii, reducerea
elasticităţii şi mobilităţii, faţă amimică).
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Sclerodermie sistemică (hialinoza ţesutului conjunctiv al dermului). (H-E).
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№ 125. Periarterită nodoasă. (Coloraţie H-E.).
31
2
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Tiroidita Hashimoto.
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№ 148. Tiroidita Hashimoto. (Coloraţie H-E.).
2
3
4
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Amiloidoza miocardului
Identificarea
macroscopică.
Reacţia macroscopică Virchow: la aplicarea succesivă pe suprafaţa de secţiune a
iodului sau a sol. Lugol şi a acidului sulfuric (10%) amiloidul se colorează în albastru-
violet sau verde-închis .
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Amiloidoza nodulară a splinei (splină sago).
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№ 21. Amiloidoza nodulară a splinei (splină sago). (Coloraţie roşu de Congo şi hematoxilină).
1
2
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Amiloidoza difuză a splinei (splină “slăninoasă”).
Imaginea de jos norma.
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Amiloidoza
renală
Rinichiul este mărit,
limita cortico-medulară
ştearsă, piramidele
palide.
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1b
1a
2
№ 19. Amiloidoza rinichiului. (Coloraţie roşu de Congo şi hematoxilină).
1c