E Antiviral medication

N D O V I R A Z A

Endoviraza®

Trade name of the product

Bacterial endonuclease

International non-proprietary name

ENDOVIRAZA®

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Registration certificate

Declaration of conformity

License for implementation of pharmaceutical activity

ENDOVIRAZA® official documents

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ENDOVIRAZA® Competitive advantages

It is the only enzyme medication in the world having a direct virusocidal effect. It is non-toxic, non-aggressive, and nonreactive towards mucosal surfaces and skin. It does not contain iodine, chlorine and other substances toxic for animal organisms.

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Beekeeping

Poultry breeding

Livestock breeding

ENDOVIRAZA® animal groups and modes of its application

Horse breeding

In the form of fine aerosol

Intranasal with fine aerosol

Treatment with “cold fog”

Intranasal with fine aerosol

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= + ENDONUCLEASE Activity 50 000 units An excipient is polysaccharide dextran – 45 mg

ENDOVIRAZA® Presentation and content of bottles

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Activator – MAGNESIUM SULPHATE 0.62 g

ENDOVIRAZA® against diseases of cattle

parainfluenza of cattle

adenoviral bronchial pneumonia of cattle

adenovirosis of cattle

infectious bovine rhinotracheitis

herpes of upper respiratory airway of cattle

shipping fever of cattle

viral respiratory infection of cattle

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ENDOVIRAZA® against diseases of horses

viral respiratory infection

infectious rhinotracheitis of colts

pneumovirus of colts

equine rhinopneumonia

parainfluenza of horses

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viral respiratory infection

avian metapneumovirus

pneumovirus of chickens

infectious laryngotracheitis of chickens

avian bronchial pneumonia

influenza, avian parainfluenza

avian infectious laryngotracheitis

avian bronchitis

Newcastle disease

ENDOVIRAZA® against poultry diseases

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acute and chronic paralysis filamentovirosis

sacbrood disease

egyptovirosis

deformed wing disease

viral diseases of bees

disease of forest honey flow

black disease

May sickness

viral paralysis

ENDOVIRAZA® against diseases of bees

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ENDOVIRAZA® Spring-and-summer stimulation of development

of bee families

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The mechanism of stimulation and development of bee families:

Elimination of latent (persistent) viruses inhibiting development of bee families.

Acceleration of decomposition of organic substances forming the basis of bee food.

Stimulating effect of the enzyme on larval bees and a queen (increase in egg laying).

Increase in the amount of brood – up to 25%

Increase in the amount of honeyflow – up to 50%

ENDOVIRAZA® Molecular structure of endonuclease

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ENDOVIRAZA® Mode of action

Animals

Intranasal,

fine aerosol,

“cold fog”

Adhesion and deep

penetration

Hydrolysis till nucleotides

Active ingredient – Bacterial endonuclease Activator – magnesium sulphate

Mucosa of respiratory passages

RNA or DNA of the virus

Prophylactic action and treatment of viral diseases of upper respiratory airway

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ENDOVIRAZA® Mode of action

Bees

Fine-divided spraying within a bee family

Penetration into bee hemolymph

Wellness of a bee family

Active ingredient – Bacterial endonuclease Activator – magnesium sulphate

Protection of a bee family against viral diseases

Stimulation of development of a bee family

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Intranasal with fine aerosol for 30 heads

Curative treatment

Preventive care

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Endonu-clease

Magne-sium sulphate + +

50 000 activity units

62 mg

2.5 ml into each nostril, once a day

Periodicity of treatment - 4-5 times at the interval of 1-3 days

2.5 ml into each nostril, once a day

Periodicity of treatment - 2 times at the interval of 7-10 days

150 ml

The working solution retains its properties for 24 hours

Water

ENDOVIRAZA® Scheme of application

Horses and cattle

Treatment with “Cold fog”

Curative treatment and preventive care

Recommendations

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Endonu-clease

Magne-sium sulphate + +

50 000 activity units

62 mg

15 ml of the solution for 1 m2 if floor-managed

15 ml of the solution for 1 m2 or 0.5 m3 if cage-managed

Periodicity of treatment of chickens (broilers) - 3 times at the interval of 3 days, beginning at 21 days-old

Periodicity of treatment of poultry (without vaccination) - 5 times at the interval of 2 days, since their first days of life

Length of a blow-off body is 5 -10 meters

Height of a sprayable layer is at least 40 sm above the ground

Size of sprayable particles is from 5 to 15 microns

500 ml

The working solution retains its properties for 24 hours

Water

ENDOVIRAZA® Scheme of application

Poultry

Treatment of 10 bee families in the form of fine aerosol

Curative treatment

Recommendations

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Endonu-clease

Magne-sium sulphate + +

50 000 activity units

62 mg

Each beeway should be sprayed with a dose of 4-5 ml for 2-3 seconds

for one bee family (10-12 standard frames) is 40-50 ml

Periodicity of treatment - up to 7 times according to indications at the interval of 7-10 days

In a spring-summer period at an air temperature above 14оС

In the morning (before bee flight) or in the evening (after bee flight)

500 ml

The working solution retains its properties for 24 hours

Water

ENDOVIRAZA® Scheme of application

Bees. Curative treatment

Treatment of 10 bee families with a solution in the form of

fine aerosol

Preventive care

Recommendations

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Endonu-clease

Magne-sium sulphate + +

50 000 activity units

62 mg

Each beeway should be sprayed with a dose of 4-5 ml for 2-3 seconds

for one bee family (10-12 standard frames) is 40-50 ml

Periodicity of treatment - at least 3 times at the interval of 7-10 days

In a spring-summer period at an air temperature above 14оС

In the morning (before bee flight) or in the evening (after bee flight)

For better over-wintering of diseased families, they are treated once at the end of the summer season before family gathering

500 ml

The working solution retains its properties for 24 hours

Water

ENDOVIRAZA® Scheme of application. Bees

Stimulation of development and preventive care

ENDOVIRAZA® Safety of application

Side effects and complications are absent

Peculiarities of action of this medication at the time of its first application or cessation are absent

When applying of this medication, symptoms of its overdose are absent

This medication is compatible with other drugs and feed supplements

Products obtained from animals that have been treated with this medication can be used without any restrictions

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Thanks for your time!

Contact details – OOO “Severniy stil” Location: 109202, Moscow Postal address: 630049, Novosibirsk, Krasniy prospekt, 153B, office 32; Phone: +7 916 656 5050 (English)

Manufacturer – JSC “Pokrov Biological Plant” Volginskiy, Petushinskiy Region, Vladimir Oblast., 601125, Novosemenkovskaya street