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+BENIGN VOCAL CHORD LESIONS
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+Introduction
n Normal voice requires
laryngeal function to be
coordinated, efficient, and physiologically stable
n Benign lesions of the vocal folds can cause imbalances in this system
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+HISTOLOGY
n The Cover
n The transition
n The body
- Epithelium (mucosa) - Basal lamina - Superficial layer of lamina propria
- Intermediate layer of lamina propria - Deep layer of lamina propria
- Vocalis muscle (thyroarytenoid muscle)
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+
COVER
n Epithelium
-Anterior glottis à stratified squamous
- Posterior glottis à pseudostratified ciliated
n Basal lamina à physical suport
- Lamina lucida
- Lamina densa
n Superficial layer of lamina propria - Reinke’s space (potential space)à Reinke’s edema
- Fibrous components + extracellular matrix
HISTOLOGY
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+
TRANSITION n Intermediate layer of the lamina propria
- Elastic fibers
n Deep layer of the lamina propria
- Collagenous fibers
BODY
- The vocalis muscle
(medial portion of the thyroarytenoid musle)
HISTOLOGY
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+Anatomy
n Mucosa and vocal ligament extend over the vocal process n Cartilaginous (aphonatory)
n Posterior one-third
n Membranous (phonatory)
n Anterior two-thirds
n Important anatomical feature n Most benign lesions affect the membranous portion
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+ BENIGN VOCAL CHORD LESIONS n NON-NEOPLASTIC
n Vocal nodules
n Vocal Polyp
n Vocal Cyst
n Reinke’s edema
n Granuloma
n Leukoplakia
n Intracordal scars
n NEOPLASTIC n Papilloma
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+Benign Non-neoplastic vocal chord lesions
n Majority of vocal fold lesions
n Causes
n Vibratory injury
n Multifactorial
n Extroverts, talkativeness
n Occupation
n Smoking, acid reflux, allergy and infection
![Page 9: BENIGN VOCAL CHORD LESIONS - SBORL€¦ · Fig.3.6.4 (a) Right vocal cord polyp a few millimeters behind the anterior commissure. (b) After excision. Mucosa was preserved as much](https://reader034.vdocuments.net/reader034/viewer/2022051807/60080fae77f20a13867105c7/html5/thumbnails/9.jpg)
+VOCAL CHORD NODULES
n Most common benign lesion of the v.c.
n Children and adult females
n Clinical presentation: hoarseness of variable duration, can have different degrees of breathiness and vocal breaks
n Risk factors: Voice misuse or abuse (professional singers, teachers, other occupations with high voice demands)
![Page 10: BENIGN VOCAL CHORD LESIONS - SBORL€¦ · Fig.3.6.4 (a) Right vocal cord polyp a few millimeters behind the anterior commissure. (b) After excision. Mucosa was preserved as much](https://reader034.vdocuments.net/reader034/viewer/2022051807/60080fae77f20a13867105c7/html5/thumbnails/10.jpg)
+VOCAL CHORD NODULES
n BILATERAL n Junction of the anterior to middle
membranous portion of vocal fold (point of the maximal shearing and collision forces)
n Vary in size, symmetry, contour, and color.
n Pathological sequence n Forceful or prolonged vibration at the membranous portion
n Edema and congestion n Long-term vocal abuse leads to hyalinization of the SLP
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+VOCAL CHORD NODULES
n Videostroboscopy n Hourglass appearance n Relatively symmetrical
mucosal wave
n Management n Voice therapy (6 months )
n Primary treatment n Optimize laryngeal environment n Phonotraumatic behaviors, guidelines for voice use, optimizing
hydration n Medical
n Reflux, smoking n Surgical (infrequent)
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+VOCAL POLYPS n Unilateral lesions
n Broad based or pedunculated
n Often in males
n Red, white, or translucent lesions at anterior/middle third along the free edge
n Causes: Vocal abuse or anticoagulant use
n Two types n Hemorrhagic – abrupt onset – extreme vocal effort n Nonhemorrhagic (pseudocyst) – outpouchings of inflamed SLP
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+VOCAL POLYPS
n Pathophysiology n Shearing forces n Capillary rupture and focal accumulation of blood or hematoma n Inflammatory cells infiltrate n New matrix
n Videostroboscopy n Usually have intact mucosal waves n Phase asymmetry with impaired glottic closure
n Fatigue, voice breaks, decreased vocal power.
![Page 14: BENIGN VOCAL CHORD LESIONS - SBORL€¦ · Fig.3.6.4 (a) Right vocal cord polyp a few millimeters behind the anterior commissure. (b) After excision. Mucosa was preserved as much](https://reader034.vdocuments.net/reader034/viewer/2022051807/60080fae77f20a13867105c7/html5/thumbnails/14.jpg)
+VOCAL POLYPS
n Management based on polyp size n Conservative management for small polyps
n Management n Medical
n Discontinue anticoagulants
n Reflux treatment
n Voice therapy
n Small polyps
n Surgical
138 Chapter 3 Throat & Neck
a bFig. 3.6.3 Vocal polyps move in and out during respiration. (a) Inspiration, (b) expiration (cour-tesy of Dr. Yılmaz)
a
b
Fig. 3.6.4 (a) Right vocal cord polyp a few millimeters behind the anterior commissure. (b) After excision. Mucosa was preserved as much as possible and anterior commissure was not touched
a
b
c
Fig. 3.6.5 (a–c) Vocal cord polyps are usually single lesions which can occur anywhere on the vocal cord. The treatment is microlar-yngoscopic removal of the polyps
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+VOCAL CHORD CYST
n Unilateral but can be bilateral
n Women > men.
n Sac like structure within the lamina propria, yellow or white in color, distinct and defined border
n Two subtypes n Epidermoid +++
n Stratified squamous epithelium
n Mucous retention n Cylindrical epithelium
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+VOCAL CHORD CYST
n PATHOGENESIS
n Epidermoid vocal chord cyst
n Epithelial cells buried congenitally
n Healing mucosa – vocal abuse
n Mucous retention cyst
n Obstruction of a glandular duct ----˃ Upper respiratory infection, voice overuse and acid reflux.
Symptoms: vocal strain, diplophonia
![Page 17: BENIGN VOCAL CHORD LESIONS - SBORL€¦ · Fig.3.6.4 (a) Right vocal cord polyp a few millimeters behind the anterior commissure. (b) After excision. Mucosa was preserved as much](https://reader034.vdocuments.net/reader034/viewer/2022051807/60080fae77f20a13867105c7/html5/thumbnails/17.jpg)
+VOCAL CHORD CYST
n Videostroboscopy n Asymmetrical mucosal wave
n Decreased on side of lesion
n Glottic closure depends
on the size of the cyst
n Management n Surgical – mainstay of treatment
n Supportive measures (hydration, reflux)
n Voice therapy
n Limited role
n Epidermoid type
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+REACTIVE LESIONS
n Response to unilateral
vocal chord lesion
n Reactive callus with vocal chord hyperplasia
n Can be confused with vocal nodules
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+REACTIVE LESIONS
n Videostroboscopy n Hourglass appearance
n Wave asymmetry unlike
vocal nodules
n Management n Treat primary lesion
n Conservative management
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+REINKE’S EDEMA n Polypoid corditis, Reinke’s edema or smoker’s polyps
n Bilateral diffuse polyposis
n Causes: Chronic irritant exposure
n RF: middle aged, talkative women with a long-term history of smoking
n Clinical presentation: n Lower pitch (masculine range)
n Fibroscopy: Outpouchings of
the membranous vocal chord n Water balloon appearance
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+REINKE’S EDEMA
n Excessive accumulation of edema
n Alterations in the walls of blood vessels
n Thickening of the epithelial basement membrane
n Connective tissue
proliferation---˃irreversible lesion
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+REINKE’S EDEMA
n Videostroboscopy n Decreased mucosal wave
n Phase asymmetry due to ball-valving and asymmetric edema
![Page 23: BENIGN VOCAL CHORD LESIONS - SBORL€¦ · Fig.3.6.4 (a) Right vocal cord polyp a few millimeters behind the anterior commissure. (b) After excision. Mucosa was preserved as much](https://reader034.vdocuments.net/reader034/viewer/2022051807/60080fae77f20a13867105c7/html5/thumbnails/23.jpg)
+REINKE’S EDEMA
n Management
n Medical - SMOKING CESSATION n Voice therapy
n May help introduce optimal vocal behavior
n Reduce size of the polyp and improve vocal functioning
n Surgery necessary when the voice remains unacceptable to the patient
n Risk of malignance: 1.7% patients with potentially malignant lesions (atypical hyperplasia, and IEN I and II)
![Page 24: BENIGN VOCAL CHORD LESIONS - SBORL€¦ · Fig.3.6.4 (a) Right vocal cord polyp a few millimeters behind the anterior commissure. (b) After excision. Mucosa was preserved as much](https://reader034.vdocuments.net/reader034/viewer/2022051807/60080fae77f20a13867105c7/html5/thumbnails/24.jpg)
+VOCAL GRANULOMA n Primarily in men
n Posterior one-third or cartilaginous glottis
n Clinical presentation: Speech may be
normal
n Causes: Vocal chord trauma n Associated with acid reflux, chronic cough, throat clearing and intubation
n Pathophysiology n Traumatic areasà ulcerationà granuloma.
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+VOCAL GRANULOMA
n Videostroboscopy n Mucosal wave present n Location in cartilaginous posterior vocal chord n Large lesions can affect closure
n Management n Treat underlying cause of irritation n Medical
n Anti-reflux regimen n Spontaneously resolve over 3-6 months
n Voice therapy n Surgical
n Recurrence is common n Reserved for lesions
n Enlarging n Affecting the voice n Suspicion for malignancy
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+CAPILLARY ECTASIA
n RF: Female singers n Clinical presentation: Hoarseness after short periods of singing
n NSF: Abnormal dilation of capillaries, can also present as clusters
n Pathophysiology n Vibratory microtrauma lead to capillary angiogenesis in the superficial
lamina propria.
Predisposes to:
• Increased vulnerability to mucosal swelling
• Vocal fold hemorrhage • Hemorrhagic polyp formation
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+CAPILLARY ECTASIA
n Management n Medical
n Discontinue anticoagulants n Acid reflux
n Voice therapy – behavioral changes for voice abusers
n Surgical n Patients who fail conservative management n Spot coagulation is an excellent option
n CO2 laser - scarring n KTP (532nm) laser
n Angiolytic n Selectively ablate vessels
![Page 28: BENIGN VOCAL CHORD LESIONS - SBORL€¦ · Fig.3.6.4 (a) Right vocal cord polyp a few millimeters behind the anterior commissure. (b) After excision. Mucosa was preserved as much](https://reader034.vdocuments.net/reader034/viewer/2022051807/60080fae77f20a13867105c7/html5/thumbnails/28.jpg)
+INTRACORDAL SCARRING
n CP: Aphonia to relatively normal speaking voice
n NSF: Scarred, stiff vocal fold cover
n Causes: n Inflammation, vocal trauma, vocal chord hemorrhage
n Scarring of the SLP or Reinke’s space n Surgery involving lamina propria and repeated epithelial procedure
n Pathophysiology n Scaring adheres the mucosa to the underlying vocal ligament, disrupting the ability
of the mucosa to oscillate freely
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+INTRACORDAL SCARRING
n Videostroboscopy n Markedly reduced or absent mucosal wave usually asymmetric n Often effects closure phase
n Management n Medical
n General medical issues that affect voice should be optimized
n Voice therapy n Voice building approach
n Strengthen the muscles involved in phonation
n Surgical n Incision with elevation of mucosa above scar with early voice therapy
n Prevention n Precise surgical technique n Early treatment of vocal trauma
![Page 30: BENIGN VOCAL CHORD LESIONS - SBORL€¦ · Fig.3.6.4 (a) Right vocal cord polyp a few millimeters behind the anterior commissure. (b) After excision. Mucosa was preserved as much](https://reader034.vdocuments.net/reader034/viewer/2022051807/60080fae77f20a13867105c7/html5/thumbnails/30.jpg)
+LEUKOPLAKIA
n White hyperkeratotic plaque which represents a change in the epithelium
n 10.2 per 100,000 (Males) n 2.1 per 100,000 (Females)
n Pathophysiology unknown n Chronic irritation – smoking
n 3 stages n No dysplasia -> mild to moderate dysplasia -> severe dysplasia
n 8-14% chance of malignant transformation
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+LEUKOPLAKIA
n Videostroboscopy n Normal to sluggish
mucosal wave n Can vary in severity but a
mucosal wave should be present
n Management n Surgical n Tissue diagnosis is necessary to rule out malignancy n Excision or laser
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+VOCAL CHORD PAPILLOMA – Neoplastic lesion
n Most common benign neoplasm (84%)
n Prevalence Rate n 4.3 per 100,000 children
n 1.8 per 100,000 adults
n HPV (strains 6 and 11 most common) n Type 11 associated with more aggressive disease
n HPV types 16 and 18 higher risk of malignant transformation
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+VOCAL CHORD PAPILLOMA
n Two types
n Juvenile: More aggressive and
bulky, exuberant tissues
resembling “clusters of grapes”. Recurrent
n Adult-onset: More localized, usually less
aggressive, less exophytic with a velvety
appearance and little projection
from the surface of the vocal chord.
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+VOCAL CHORD PAPILLOMA
n Videostroboscopy n Mass effect with decreased mucosal wave
n Management n Surgery
n CO2 laser n Most widely accepted n Risk – scarring
n Pulse Dye and KTP n Microdebrider
n Bulky lesions n Adjuvant treatment
n Interferon n Cidofovir (antiviral) n Bevacizumab
n Vaccine (Gardasil) n Incidence of RRP n Herd immunity
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+REFERENCES
n Altman, Kenneth W. "Vocal Fold Masses." Otolaryngologic Clinics of North America 40.5 (2007): 1091-108.
n Cohen, Seth M., et al. "Prevalence and causes of dysphonia in a large treatment‐seeking population." The Laryngoscope 122.2 (2012): 343-348.
n Cummings, Charles W., and Paul W. Flint. "Benign Vocal Fold Mucosal Disorders." Cummings Otolaryngology - Head and Neck Surgery. Philadelphia, PA: Mosby Elsevier, 2010.
n Gi, REA Tjon Pian, et al. "Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis: an international retrospective study on 635 RRP patients." European Archives of Oto-Rhino-Laryngology (2013): 1-9.
n Karkos, Petros D., and Maxwell McCormick. "The etiology of vocal fold nodules in adults." Current Opinion in Otolaryngology & Head and Neck Surgery 17.6 (2009): 420-423.
n Martins, Regina Helena Garcia, et al. "Vocal Polyps: Clinical, Morphological, and Immunohistochemical Aspects." Journal of Voice 25.1 (2011): 98-106.
n Simpson, Blake, and Clark Rosen. Operative Techniques in Laryngology. Berlin: Springer Bln, 2008.
n Venkatesan, Naren N., Harold S. Pine, and Michael P. Underbrink. "Recurrent respiratory papillomatosis." Otolaryngologic Clinics of North America 45.3 (2012): 671.
n Zeitels, Steven M., et al. "Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study." The Annals of otology, rhinology, and laryngology 120.10 (2011): 627-634.