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Biotechnological Research under Horizon 2020
Deutsche Biotechnologietage 2014
Hamburg, 09 April 2014
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1) Enhance competitiveness of EU industries and create additional highly-skilled jobs
• building competitive bio-based industries and value chains in the EU
2) Moving to a low carbon economy
• Reducing GHG emissions
• 'Cascading principle' and 'Closing the loops'
3) Re-instate economic growth in rural areas
• Sustainable valorisation of all resources (edible/non-edible) from agriculture and forestry
4) Increase independence from fossil resources
• Utilising alternative resources
5) Raising the contribution of industry to EU GDP to 20% by 2020
Main EU policy goals reflected in Horizon 2020
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EU 2030 emission reduction targets (as of February 2014)
CO2 emission reduction: 40%
Share of renewable energy in the EU: 27%
Rough estimate for EU industry: - 300 mio t CO2 by 2030
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• The potential contribution of IB to Gross Value Added to date is in the 50-60 billion € range globally; it is estimated to total 300 billion € by 2030
• Europe is the world leading producer of enzymes (75%)
• Europe is heading the implementation of Industrial Biotechnology (IB) for fine chemicals
• Nearly 70% of the IB's R&D expenditure by leading companies worldwide spent by European firms
• Worldwide, industrial biotechnology is in the focus!
• Pike Research: almost 1800 biorefineries to be commissioned globally until 2022 (e.g. US, Brazil, China, Malaysia, India, Thailand)
• $ 1.4 billion of public funding was allocated to the development of advanced biofuels in the US in 2011;
The EU: Industrial leadership in biotechnology
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Biotechnology today: opportunities for jobs and growth
• ● The example of the EU Chemical Industry
• - in 2020 combined sales of € 491 billion, € 50 billion or 10% thereof bio-based;
• - bio-based chemicals share expected to rise until 2030 to 30% of sales (thus € 150 billion annual sales, affecting up to 400.000 jobs)
• - Technology leadership in support of competitiveness will be instrumental for securing a high market share of EU industries and EU jobs.
• ● And EU Agriculture and Forestry?
• - Feedstock costs in biorefineries typically 25-40% of final product value;
• - Estimated additional € 100 billion bio-based products in the chemical industry would represent an additional market value of € 25 billion for biomass production and logistics in the EU
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Potential for EU regions in bio-based industries
© Dalberg Study 2011
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Source: Prof Dr.-Ing Christian Paulik, Johannes Kepler University Linz
The biomass issue: an example from an agricultural perspective
/1.74
World market prices per mt as of Feb 2014: Crude oil € 550; Sugar € 350 – 400; Straw € 50 - 100
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Positive effects realised due to biotechnology/ biochemistry replacing conventional processes
• Vitamin B2 production: 1 fermentation process replaced an 8-step combined chemical-biotechnological synthesis route; 7 solvents made redundant, waste reduction 75%, cost reduction 20%.
• Cephalexin antibiotic: 13 chemical steps replaced by 1 fermentative and 2 enzymatic steps; 65% less energy and materials, 50% lower costs.
• Captopril: ACE inhibitor to treat high-blood pressure. Building blocks D-b-hydroxy-isobutyric acid and L-proline synthesized by fermentation, and linked by conventional chemistry.
• PLA: One-step fermentation replaces chemical/catalytic polymerisation of other plastics, such as HDPE, LDPE etc. Depending on which plastic is replaced, PLA can reduce emissions by up to 80%, water consumption by up to 90%, and eliminates the use of solvents in the process. In comparison to conventional polymers, PLA is biodegradable!
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Source: NREL 2004 The value added chemicals from biomass volume 1
Overview biochemical synthesis, non-exhaustive
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Main current challenges
• Improving overall process sustainability
• Alternative inputs (e.g. food waste), increasing energy efficiency, reducing required process steps
• Product yields
• Genetic engineering for strain optimization
• Cultivation inputs and conditions
• Product recovery
• More energy efficient processes
• Contineous batch production
• Product quality
• Aim for 100% product purity
And
• Expanding the portfolio: new technologies, products and product functionalities
• New microbes, metabolic pathways and new enzymes
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FP7 KBBE ~ € 650 mio
Novel sources of biomass and bioproducts
Marine and fresh-water biotechnology
Biorefinery
Societal challenge 2
Food security, sustainable agriculture, marine and maritime research and the bioeconomy
•JTI
•Marine biotechnology research
Environmental biotechnology
Emerging trends in biotechnology
Industrial biotechnology
LEIT Biotechnology
• Biotechnology-based industrial processes, including environmental biotechnology
• Boosting cutting-edge biotechnologies as future innovation drivers
• Innovative and competitive platform technologies
NEW
Horizon 2020 > € 1500 mio
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• Biotechnology-based industrial processes driving competitiveness and sustainability
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Aim: Maintain European leadership in industrial and environmental biotechnology.
Biocatalysts and bio-processing: bioprospecting, optimization of biocatalysts and biocatalytic process design
Novel and improved microorganisms: understanding gene expression in the light of stress conditions; understanding mixed cultures and the dynamics of microbial communities
Bioreactors and downstream processing: address possible bottlenecks in downstream processing and facilitate the transfer of new developments into operational environments
Environmental biotechnology: focussing on the development and practical use of know-how in terms of bioprospecting; biodetection of environmental pollution; bioremediation
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• Cutting-edge biotechnologies as future innovation drivers
Aim: Assuring that the European industry stays at the forefront of
innovation, also in the medium and long term
Synthetic biology: creation of minimal cells, design of robust and sustainable bio-molecular circuits and pathways, biosafety and bioethics
Systems biology: investigating the operations of biological systems in order to optimize industrial applications of biotechnology
Bioinformatics: provision of powerful tools to store, retrieve and analyse biological data, in support of modelling and process design
Nano-biotechnology: combining both fields of research for application development in a wide range of sectors, biosafety and bioethics
Biotechnology in ICT: provision of ICT-devices incorporating biological materials
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• Innovative and competitive platform technologies
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Aim: Develop platform biotechnologies for a wide range of sectors in support of industrial leadership.
Platform technologies: Development of platform technologies and their integration across applications in support of the commercial use of biotechnology
Industrial applications of 'omics': Bringing closer to the market 'omics'-derived industrial applications, including prototyping and demonstration
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PPPs in Horizon 2020
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Joint Technology Initiatives Contractual PPPs
• Innovative Medicines (IMI)
• Clean Sky
• Single European Sky ATM Research (SESAR)
• Fuel Cells and Hydrogen (FCH)
• Electronic Components and Systems (ECSEL - old ARTEMIS + ENIAC)
New:
• Bio-based Industries (BBI)
• Factory of the Future (FoF)
• Energy-efficient Buildings (EeB)
• Green Vehicles (EGVI)
• Future internet (5G)
New:
• Sustainable Process Industry (SPIRE)
• Robotics
• Photonics
• High Performance Computing
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• Value Chain 1: From lignocellulosic feedstock to advanced biofuels, bio-based
chemicals and biomaterials: realising the feedstock and technology base for the
next generation of fuels, chemicals and materials
• Value Chain 2: The next generation forest-based value chains: utilisation of the
full potential of forestry biomass by improved mobilisation and realisation of new
added value products and markets
• Value Chain 3: The next generation agro-based value chains: realising the
highest sustainability and added value by improved agricultural production, and new
added value products and markets
• Value Chain 4: Emergence of new value chains from (organic) waste: from waste
problems to economic opportunities by realising sustainable technologies to convert
waste into valuable products
• Value Chain 5: The integrated energy, pulp and chemicals biorefineries:
realising sustainable bio-energy production, by backwards integration with biorefinery
operations isolating higher added value components
The strategic research agenda of the BBI JTI
http://biconsortium.eu/sites/default/files/downloads/BIC_SIRA_web.pdf
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LEIT and SPIRE support the full value chain of the PROCESS industry
From Base Chemicals and Fuels over new Carbon
Nanotubes, Nano-structured Catalysts, new Chemical Pathways to Hybrid Materials for
Membranes, Electronics and Lighting as well as New Process Technologies, Structural
Materials for Manufacturing and Construction and Business Models.
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Thank you for your attention!
Horizon2020: ec.europa.eu/research/horizon2020 Participant Portal (calls, experts, projects): ec.europa.eu/research/participants/portal/page/home Public-Private Partnership on bio-based industries: http://biconsortium.eu/