Download - Blood transfusion 2
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Noha M. El Husseiny, MD Clinical Haematology Unit
Cairo University
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Red blood cell transfusionWhole blood450ml contains adequate coagulation
factors but less platelets.Rarely used nowadays.
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Fresh Frozen PlasmaPreparation from whole blood separated and
frozen within 8 hours can be kept up to one year.
Volume 200 ml bloodTo increase factor by 20%need 10-20 ml/kgProperties Expire in 24h after thawing
however thawed plasma can be relabelled and used within five days in TTP.
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Cryoprecipitate
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CryoprecipitateThe insoluble part of plasma when thawed
to 4 C10-20 mlProperties rich in factor VIII, fibrinogen,
factor XIII and VWF (variable concentrate)Correction of hypofibrinogenemia (need 8-
10 units) if fibrinogen 50-100mg/ L
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Factor concentratesRecombinant factor VIIIRecombinant factor VIIFactor IX concentratesVWF concentrate
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Packed red blood cellPreparation are separated from whole
blood by centrifugation. Unit is 200ml. Increase HB 1-2 g/ml
Indications: transfusion if HB less than 6g/dl
Stored up to 6 weeks.
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Warming of blood components
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Leuko-reduced packed RBCs Contain less than 107 leukocytes per
unit.Used to reduce CMV infection, HLA
immunization, Febrile reaction and platelet transfusion refractoriness.
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Leukoreduced gamma irradiated PRBCs For patients in transplants
Washed RBCs using saline to reduce allergic reaction.
Frozen RBCs: Add glycerol and freeze RBCs within 6 days of collection used in preserving rare groups for long time than 42 days.
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Platelet preparation
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Platelet transfusionPreparation may be separated from
whole blood or collected by apharesis. Stable for 72 HIndications: Thrombocytopenia.Contraindications TTP, HIT
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ImmunoglobulinsPreparation by cold ethanol fractionation
of large pool of plasma followed by viral inactivation.
Uses treatment of ITP, Guillian Barre syndrome, chronic inflammatory demyelinating polyneuropathy, replacement in immunodeficiency syndrome.
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Blood Group
Antigens Antibodies
Can give blood to
Can receive blood from
AB
A
B
O
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Blood Group
Antigens Antibodies
Can give blood to
Can receive blood from
AB A and B None AB AB, A, B, O
A A B A and AB A and O
B B A B and AB B and O
O None A and B AB, A, B, O
O
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Plasma pharesisMethodsIndications1- TTP2-Cryoglobulinemia3- Cutaneous T cell lymphoma4-Guillian Barre syndrome5-Hyperviscosity syndrome in monoclonal gammopathy6-leukostasis7-Myasthenia gravis8- familial hypercholestrolemia9-Goodpasture syndrome
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Thank You