Can Less Frequent Deep Can Less Frequent Deep Breaths Be Protective in Breaths Be Protective in
Asthma?Asthma?
Amir H. Golnabi, R. Scott Harris, Jose G. Venegas,
and Tilo WinklerPulmonary Imaging and Bioengineering Lab
Massachusetts General Hospital, Harvard Medical School
Boston, MABiomedical Engineering Society Annual Meeting
Seattle, WASeptember 25-28, 2013
Airway constriction in asthma
http://www.webmd.com/asthma/ss/slideshowasthma-overview
Deep breaths (DBs) and their bronchodilatory effects
* Venegas and Winkler et al, Nature 434: 777–782, 2005.
Integrative computational model of bronchoconstriction*
Effects of DBs on bronchoconstriction*
* Golnabi et al, ATS 2013 Annual International Conference.
Effects of DBs on bronchoconstriction*
* Golnabi et al, ATS 2013 Annual International Conference.
Synergistic effect of frequency and volume of DBs on bronchoconstriction*
Tim
e in
terv
als
with
one
DB
and
no
rma
l tid
al b
rea
ths
in b
etw
een
Relative tidal volume of DBs (VTDB / mean VT)
Average Fc over the last complete DB cycle
* Golnabi et al, ATS 2013 Annual International Conference.
Synergistic effect of frequency and volume of DBs on bronchoconstriction*
Fc vs. time (800 breaths)
* Golnabi et al, ATS 2013 Annual International Conference.
* Golnabi et al, ATS 2013 Annual International Conference.
Synergistic effect of frequency and volume of DBs on bronchoconstriction*
Normalized Airway Radius vs. time (last 100
breaths)
Effect of lower frequency (extended time gap in between) and higher volume of DBs on the emergence of ventilation defects
Relative tidal volume of DBs (VTDB / mean VT)
Tim
e in
terv
als
with
one
D
B a
nd n
orm
al ti
dal
brea
ths
in b
etw
een
Relative tidal volume of DBs (VTDB / mean VT)
Fc vs. time (800 breaths)Average Fc over the last complete DB cycle
Effect of lower frequency (extended time gap in between) and higher volume of DBs on the emergence of ventilation defects
Relative tidal volume of DBs (VTDB / mean VT)
Tim
e in
terv
als
with
one
DB
and
no
rmal
tid
al b
reat
hs in
bet
wee
n Normalized Airway Radius vs. time (800
breaths)
Thank you!Thank you!
