1
研究業績リスト
論文 1. Kohsuke Aikawa, Hiroki Serizawa, Koki Ishii, Koichi Mikami
“Palladium-Catalyzed Negishi Cross-Coupling Reaction of Aryl Halides with
(Difluoromethyl)zinc Reagent”
Org. Lett. 2016, ASAP DOI: 10.1021/acs.orglett.6b01734
2. Hiroki Serizawa, Koki Ishii, Kohsuke Aikawa, Koichi Mikami
“Copper-Catalyzed Difluoromethylation of Aryl Iodides with (Difluoromethyl)zinc Reagent”
Org. Lett. 2016, ASAP DOI: 10.1021/acs.orglett.6b01733
3. Kazuyuki Negishi, Kohsuke Aikawa, Koichi Mikami
“Hexafluoroacetone as Air-Stable, Liquid Reagent for Trifluoromethylations”
Eur. J. Org. Chem. 2016, DOI: 10.1002/ejoc.201600711
4. Kohsuke Aikawa, Kenichi Maruyama, Junki Nitta, Ryota Hashimoto, Koichi Mikami
“Siladifluoromethylation and Difluoromethylation onto C(sp3), C(sp
2), and C(sp) Centers
Using Ruppert-Prakash Reagent and Fluoroform”
Org. Lett. 2016, 18 (14), 3354-3357. DOI: 10.1021/acs.orglett.6b01476
5. Shingo Kawashima, Kohsuke Aikawa, Koichi Mikami
“Rhodium-Catalyzed Hydrocarboxylation of Olefins with Carbon Dioxide”
Eur. J. Org. Chem. 2016, (19), 3166-3170. DOI: 10.1002/ejoc.201600338
One of most accessed articles in May 2016
6. Kohsuke Aikawa, Koichi Mikami
“Catalytic Asymmetric Synthesis of Fluoroalkylated Compounds using Chiral Dicationic
Palladium Complexes”
J. Synth. Org. Chem., Jpn. (Yuki Gosei Kagaku Kyokaishi) 2016, 74 (3), 219-232.
7. Shigekazu Ito, Masaki Nanko, Tomokazu Shinozaki, Masafumi Kojima, Kohsuke Aikawa,
Koichi Mikami
“Dynamic Chirality Control of tropos DPCB-digold Skeleton by Chiral Binaphthyl-
dicarboxylate”
Chem. Asian J. 2016, 11 (6), 823-827. DOI: 10.1002/asia.201501326
8. Tsuyuka Sugiishi, Hideki Amii, Kohsuke Aikawa, Koichi Mikami
“Carbon-carbon bond cleavage for Cu-mediated aromatic trifluoromethylations and
pentafluoroethylations”
Beilstein J. Org. Chem. 2015, 11, 2661-2670. DOI: 10.3762/bjoc.11.286
9. Kohsuke Aikawa, Seiya Yoshida, Daisuke Kondo, Yuya Asai, and Koichi Mikami
“Catalytic Asymmetric Synthesis of Tertiary Alcohols and Oxetenes Bearing a
Difluoromethyl Group”
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Org. Lett. 2015, 17 (20), 5108-5111. DOI: 10.1021/acs.orglett.5b02617
Highlighted in Synfacts, 2015, 11 (12), 1293. DOI: 10.1055/s-0035-1560937
Highlighted in ChemInform, 2016, 47 (9), 09-085. DOI: 10.1002/chin.201609085
10. Kohsuke Aikawa, Wataru Toya, Yuzo Nakamura, and Koichi Mikami
“Development of (Trifluoromethyl)zinc Reagent as Trifluoromethyl Anion and
Difluorocarbene Sources”
Org. Lett. 2015, 17 (20), 4996-4999. DOI: 10.1021/acs.orglett.5b02439
One of the journal’s top 20 most downloaded articles for October 2015
Highlighted in Synfacts, 2015, 11 (12), 1315. DOI: 10.1055/s-0035-1560863
11. Kohsuke Aikawa, Kenichi Maruyama, Kazuya Honda, and Koichi Mikami
“-Difluoromethylation on sp3 Carbon of Nitriles Using Fluoroform and Ruppert–Prakash
Reagent”
Org. Lett. 2015, 17 (19), 4882-4885. DOI: 10.1021/acs.orglett.5b02438
Highlighted in J. Synth. Org. Chem., Jpn. 2016, 74 (3), 279.
12. Kohsuke Aikawa, Daisuke Kondo, Kazuya Honda, and Koichi Mikami
“Lewis Acid-Catalyzed Asymmetric Three-Component Coupling Reaction: Facile Synthesis
of α-Fluoromethylated Tertiary Alcohols”
Chem. Eur. J. 2015, 21 (49), 17565-17569. DOI: 10.1002/chem.201503631
日刊工業新聞 27 面,掲載日 2015.7.14「炭素-炭素結合 2 種立体異性 一度の反応で作製
東工大」
Highlighted in Synfacts, 2016, 12 (3), 0285. DOI: 10.1055/s-0035-1561731
13. Kohsuke Aikawa, Yuzo Nakamura, Yuki Yokota, Wataru Toya, and Koichi Mikami
“Stable but Reactive Perfluoroalkylzinc Reagents: Application to Ligand-Free Copper-
Catalyzed Perfluoroalkylation of Aryl Iodides”
Chem. Eur. J. 2015, 21 (1), 96-100. DOI: 10.1002/chem.201405677
Highlighted in Synfacts, 2015, 11 (2), 0185. DOI: 10.1055/s-0034-1379800
14. Kohsuke Aikawa, Yuya Asai, Yūta Hioki, Koichi Mikami
“Catalytic and highly enantioselective Friedel-Crafts type reactions of heteroaromatic
compounds with trifluoropyruvate and glyoxylate by a dicationic palladium complex”
Tetrahedron: Asymmetry 2014, 25 (15), 1104-1115. DOI: 10.1016/j.tetasy.2014.06.013
15. Hiroki Serizawa, Kohsuke Aikawa, Koichi Mikami
“Direct Synthesis of Pentafluoroethyl Copper from Pentafluoropropionate as an Economical
C2F5 Source: Application to Pentafluoroethylation of Arylboronic Acids and Aryl Bromides”
Org. Lett. 2014, 16 (13), 3456-3459. DOI: 10.1021/ol501332g
One of the journal’s top 20 most downloaded articles for June 2014
Highlighted in Synfacts, 2014, 10 (10), 1069. DOI: 10.1055/s-0034-1379116
Highlighted in J. Synth. Org. Chem., Jpn. 2015, 73 (2), 187.
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16. Ryota Hashimoto, Toshiaki Iida, Kohsuke Aikawa, Shigekazu Ito, Koichi Mikami
“Direct -Siladifluoromethylation of Lithium Enolates with Ruppert-Prakash Reagent via C-
F Bond Activation”
Chem. Eur. J. 2014, 20 (10), 2750-2754. DOI: 10.1002/chem.201304473
One of most accessed articles in February 2014
Highlighted in Synfacts, 2014, 10 (5), 0518. DOI: 10.1055/s-0033-1341209
17. Motohiro Fujiu, Ryota Hashimoto, Yuzo Nakamura, Kohsuke Aikawa, Shigekazu Ito, Koichi
Mikami
“Paradigm Shift from Alkaline (Earth) Metals to Early Transition Metals in
Fluoroorganometal Chemistry: Perfluoroalkyl Titanocene(III) Reagents Prepared via Not
Titanocene(II) but Titanocene(III) Species”
Chem. Eur. J. 2014, 20 (8), 2382-2386. DOI: 10.1002/chem.201303089
18. Kohsuke Aikawa, Natsumi Shimizu, Kazuya Honda, Yūta Hioki, Koichi Mikami
“Effect of the trifluoromethyl group on torquoselectivity in the 4π ring-opening reaction of
oxetenes: stereoselective synthesis of tetrasubstituted olefins”
Chem. Sci. 2014, 5 (1), 410-415. DOI: 10.1039/C3SC52548A
19. Hiroki Serizawa, Kohsuke Aikawa, Koichi Mikami
“Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones:
Application to Trifluoromethylation”
Chem. Eur. J. 2013, 19 (52), 17692-17697. DOI: 10.1002/chem.201303828
One of most accessed articles in November 2013
Highlighted in Synfacts, 2014, 10 (3), 0310.
20. Yuzo Nakamura, Motohiro Fujiu, Tatsuya Murase, Yoshimitsu Itoh, Hiroki Serizawa,
Kohsuke Aikawa, Koichi Mikami
“Cu-catalyzed trifluoromethylation of aryl iodides with trifluoromethylzinc reagent prepared
in situ from trifluoromethyl iodide”
Beilstein J. Org. Chem. 2013, 9, 2404-2409. DOI: 10.3762/bjoc.9.277
21. Kohsuke Aikawa, Koichi Mikami
“Development of Catalytic Asymmetric Reactions Based on Chirally Flexible (Tropos)
Ligands”
J. Synth. Org. Chem., Jpn. (Yuki Gosei Kagaku Kyokaishi) 2012, 70 (12), 45-58.
22. (Feature Article)
Kohsuke Aikawa, Koichi Mikami
“Asymmetric Catalysis based on Tropos Ligands”
Chem. Commun. 2012, 48 (90), 11050-11069. DOI: 10.1039/C2CC34320G
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23. Motohiro Fujiu, Yuzo Nakamura, Hiroki Serizawa, Kohsuke Aikawa, Shigekazu Ito, Koichi
Mikami
“Direct Preparation of Trifluoromethylindium Reagents from Trifluoromethyl Iodide:
Effective Trifluoromethylation and Perfluoroalkylation Reagents”
Eur. J. Org. Chem. 2012, (36), 7043-7047.
24. Toshiaki Iida, Ryota Hashimoto, Kohsuke Aikawa, Shigekazu Ito, Koichi Mikami
“Umpolung of Fluoroform by C-F Bond Activation: Direct Difluoromethylation of Lithium
Enolates”
Angew. Chem. Int. Ed. 2012, 51 (38), 9535-9538.
Highlighted in Synfacts, 2012, 8 (12), 1356.
25. Kohsuke Aikawa, Tatsuya Okamoto, Koichi Mikami
“Copper(I)-Catalyzed Asymmetric Desymmetrization: Synthesis of Five-Membered-Ring
Compounds Containing All-Carbon Quaternary Stereocenters”
J. Am. Chem. Soc. 2012, 134 (25), 10329-10332.
Highlighted in Synfacts, 2012, 8 (9), 1000.
Highlighted in ChemInform, 2012, 43 (49), December 4.
One of the journal’s top 20 most downloaded articles for June 2012.
26. Kohsuke Aikawa, Yoshitaka Miyazaki, Koichi Mikami
“Stable Axial Chirality in Metal Complexes Bearing 4,4’-Substituted BIPHEPs: Application
to Catalytic Asymmetric Carbon-Carbon Bond-Forming Reactions”
Bull. Chem. Soc. Jpn. 2012, 85 (2), 201-208.
Selected Papers
Highlighted in J. Synth. Org. Chem., Jpn. 2012, 70 (8), 865.
27. Kohsuke Aikawa, Yūta Hioki, Natsumi Shimizu, Koichi Mikami
“Catalytic Asymmetric Synthesis of Stable Oxetenes via Lewis Acid-promoted [2 + 2]
Cycloaddition”
J. Am. Chem. Soc. 2011, 133 (50), 20092-20095.
Highlighted in Synfacts, 2012, 8 (3), 0279.
Highlighted in Industrial Catalyst News (触媒学会工業触媒研究会), No. 57 April 1, 2011.
日刊工業新聞 1面,掲載日 2011.3.21「東工大、触媒反応でオキセテンの不斉合成に成功」
28. Koichi Mikami, Kohsuke Aikawa, Junpei Aida
“Fragment-Based Reaction Discovery of Non-Ene-Type Carbon-Carbon Bond-Forming
Reactions: Catalytic Asymmetric Oxetane Synthesis by Screening Olefinic Reactants without
Allylic Hydrogen”
Synlett 2011, (18), 2719-2724. DOI: 10.1055/s-0031-1289540
Highlighted in Synfacts, 2012, 8 (2), 0192.
29. Kohsuke Aikawa, Kazuya Honda, Shunsuke Mimura, Koichi Mikami
“Highly enantioselective Friedel-Crafts alkylation of indole and pyrrole with ,-unsaturated
-ketoester catalyzed by chiral dicationic palladium complex”
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Tetrahedron Lett. 2011, 52 (50), 6682-6686.
30. Kohsuke Aikawa, Shunsuke Mimura, Yukinobu Numata, Koichi Mikami
“Palladium-Catalyzed Enantioselective Ene and Aldol Reactions with Isatins, Keto Esters,
and Diketones: Reliable Approach to Chiral Tertiary Alcohols”
Eur. J. Org. Chem. 2011, (1), 62-65.
Highlighted in Synfacts, 2011, (4), 0417.
31. Kohsuke Aikawa, Yūta Hioki, Koichi Mikami
“Highly Enantioselective Alkynylation of Trifluoropyruvate with Alkynylsilanes Catalyzed
by the BINAP-Pd Complex: Access to -Trifluoromethyl-Substituted Tertiary Alcohols”
Org. Lett. 2010, 12 (24), 5716-5719.
Highlighted in Synfacts, 2011, (3), 0280.
32. Kohsuke Aikawa, Masafumi Kojima, Koichi Mikami
“Synergistic Effect: Hydroalkoxylation of Allenes through Combination of Enantiopure
BIPHEP-Gold Complexes and Chiral Anions”
Adv. Synth. Catal. 2010, 352 (18), 3131-3135.
Highlighted in Synfacts, 2011, (3), 0295.
One of the most accessed articles in February 2011
33. Kohsuke Aikawa, Yūta Hioki, Koichi Mikami
“Catalytic Enantioselective Arylation of Glyoxylate with Arylsilanes: Practical Synthesis of
Optically Active Mandelic Acid Derivatives”
Chem. Asian J. 2010, 5 (11), 2346-2350.
One of the most accessed articles in March 2011
34. Kohsuke Aikawa, Yūta Hioki, Koichi Mikami
“Highly Enantioselective Alkenylation of Glyoxylate with Vinylsilane Catalyzed by Chiral
Dicationic Palladium(II) Complexes”
J. Am. Chem. Soc. 2009, 131 (39), 13922-13923.
Highlighted in Synfacts, 2010, (1), 0082.
35. Kohsuke Aikawa, Masafumi Kojima, Koichi Mikami
“Axial Chirality Control of Gold(biphep) Complexes by Chiral Anions: Application to
Asymmetric Catalysis”
Angew. Chem. Int. Ed. 2009, 48 (33), 6073-6077.
Highlighted in Synfacts, 2009, (11), 1241.
36. Kazuki Wakabayashi, Kohsuke Aikawa, Koichi Mikami
“CHIRALITY CONTROL OF TROPOS DIPHENYLMETHANE-DERIVED
PHOSPHORAMIDITES BY CHIRAL DIENES: ITS APPLICATION TO ASYMMETRIC
MICHAEL ADDITION”
Heterocycles 2009, 77 (2), 927-943.
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37. Kohsuke Aikawa, Yuki Takabayashi, Susumu Kawauchi, Koichi Mikami
“Axial chirality control of tropos BIPHEP-Rh complexes by chiral dienes: synergy effect in
catalytic asymmetric hydrogenation”
Chem. Comm. 2008, (41), 5095-5097. DOI: 10.1039/B809683J
38. Kazuki Wakabayashi, Kohsuke Aikawa, Koichi Mikami
“BENZOPHENONE-DERIVED CATALYST WITH SELF-ADAPTATION: HIGHLY
ENANTIOSELECTIVE HYDROGENATION IRRESPECTIVE OF SUBSTRATES”
Heterocycles 2008, 76 (2), 1525-1535.
39. Kazuki Wakabayashi, Kohsuke Aikawa, Susumu Kawauchi, Koichi Mikami
“Catalyst Self-Adaptation in Conjugate Addition to Nitroalkenes and Nitroacrylates: Instant
Chirality Control in Diphenylmethane-Based Phosphoramidite Ligands”
J. Am. Chem. Soc. 2008, 130 (15), 5012-5013.
Highlighted in Synfacts, 2008, (7), 0729.
40. Kohsuke Aikawa, Isao Kaito, Koichi Mikami
“Enantiofacial Control of Planar Chiral Arene Ru Complexes Bearing Tropos Biphenyl
Ligands”
Chem. Lett. 2007, 36 (12), 1482-1483.
41. Koichi Mikami, Yuji Kawakami, Katsuhiro Akiyama, Kohsuke Aikawa
“Enantioselective Catalysis of Ketoester-Ene Reaction of Silyl Enol Ether to Construct
Quaternary Carbons by Chiral Dicationic Palladium(II) Complexes”
J. Am. Chem. Soc. 2007, 129 (43), 12950-12951.
Selected “SynStory” in SYNFORM
Highlighted in Synfacts, 2008, (1), 0045.
科学新聞 4面,掲載日 2007.9.28「不斉合成で4級炭素構築 医薬品産業などへ展開期待」
日刊工業新聞 24 面,掲載日 2007.8.22「独自触媒プロセス開発 医薬中間体 高品質・低
コスト製造へ」
42. Fumihiko Saitoh, Hidemitsu Nishida, Takafumi Mukaihira, Kohsuke Aikawa, Koichi
Mikami
“Dynamic Kinetic Resolution for the Catalytic Asymmetric Total Synthesis of
Antithrombotic Agents M58163 and M58169”
Adv. Synth. Catal. 2007, 349 (4-5), 617-628.
43. Kohsuke Aikawa, Susumu Akutagawa, Koichi Mikami
“Asymmetric Synergy between Chiral Dienes and Diphosphines in Cationic Rh(I)-Catalyzed
Intramolecular [4+2] Cycloaddition”
J. Am. Chem. Soc. 2006, 128 (39), 12648-12649.
Highlighted in Synfacts, 2007, (1), 0064.
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44. Koichi Mikami, Shohei Kataoka, Kazuki Wakabayashi, Kohsuke Aikawa
“Chiral Aminoalcohol NOBIN for Instantaneous Chirality Control of Racemic but Tropos
BIPHEP-Rh(I)-Complexes: Highly Enantioselective Ene-Type Cyclization of 1,6-Enynes
Catalyzed by the Rh(I)-Complexes without Use of Acid”
Tetrahedron Lett. 2006, 47 (36), 6361-6364.
45. Fumihiko Saitoh, Hidemitsu Nishida, Takafumi Mukaihira, Kohsuke Aikawa, Koichi
Mikami
“Asymmetric Synthesis of Antithrombotic Agents M58163 and M58169: Dynamic Kinetic
Resduction in Amide Formation Catalyzed by La-Linked BINOL Complex”
Eur. J. Org. Chem. 2006, (24), 5454-5457.
46. Koichi Mikami, Kazuki Wakabayashi, Yukinori Yusa, Kohsuke Aikawa
“Achiral benzophenone ligand-rhodium complex with chiral diamine activator for high
enantiocontrol in asymmetric transfer hydrogenation”
Chem. Commun. 2006, (22), 2365-2367. DOI: 10.1039/B517585B
Selected as a Hot Paper
47. Fumihiko Saitoh, Hidemitsu Nishida, Takafumi Mukaihira, Kohsuke Aikawa, Koichi
Mikami
“Asymmetric Synthesis of Antithrombotic Agent M55529: The First Enantioselective Cyclic
N,O-Acetal Formation”
Eur. J. Org. Chem. 2006, (10), 2269-2272.
48. Koichi Mikami, Kazuki Wakabayashi, Kohsuke Aikawa
““Achiral” Benzophenone Ligand for Highly Enantioselective Ru Catalysts in Ketone
Hydrogenation”
Org. Lett. 2006, 8 (8), 1517-1519.
49. Koichi Mikami, Hitomi Kakuno, Kohsuke Aikawa
“Enantiodiscrimination and Enantioontrol of Neutral and Cationic PtII Complexes Bearing
the Tropos Biphep Ligand: Application to Asymmetric Lewis Acid Catalysis”
Angew. Chem. Int. Ed. 2005, 44 (44), 7257-7260.
50. Kohsuke Aikawa, Koichi Mikami
“Dual Chirality Control of Palladium(II) Complexes Bearing Tropos Biphenyl Diamine
Ligands”
Chem. Commun. 2005, (46), 5799-5801.
51. Yuko Matsuoka, Kohsuke Aikawa, Ryo Irie, Tsutomu Katsuki
“Asymmetric synthesis of cryptofolione and determination of its absolute configuration”
Heterocycles 2005, 66 (1), 187-194.
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52. Koichi Mikami, Shohei Kataoka, Kohsuke Aikawa
“Tropos or Atropos Nature of Rhodium Complexes Bearing a Tetrakis(phosphanyl)terphenyl
Ligand: Highly Enantioselective Catalysis of Ene-Type Cyclization”
Org. Lett. 2005, 7 (26), 5777-5780.
53. Koichi Mikami, Shohei Kataoka, Yukinori Yusa, Kohsuke Aikawa
“Racemic but Tropos (Chirally Flexible) BIPHEP Ligands for Rh(I)-Complexes: Highly
Enantioselective Ene-Type Cyclization of 1,6-Enynes”
Org. Lett. 2004, 6 (21), 3699-3701.
54. Koichi Mikami, Kohsuke Aikawa, Yamanaka Masahiro
“Negative Nonlinear Effect in Aqua Palladium Catalysis Depending on Tropos
Biphenylphosphine Ligand Chirality Controlled by Chiral Diaminobinaphthyl Activator”
Pure Appl. Chem. 2004, 76 (3), 537-540.
55. Koichi Mikami, Yukinori Yusa, Manabu Hatano, Kazuki Wakabayashi, Kohsuke Aikawa
“Highly enantioselective spiro cyclization of 1,6-enynes catalyzed by cationic skewphos
rhodium(I) complex”
Chem. Commun. 2004, (1), 98-99.
56. Kohsuke Aikawa, Satoshi Kainuma, Manabu Hatano, Koichi Mikami
“Asymmetric Catalysis of Ene Reactions with Trifluoropyruvate Catalyzed by Dicationic
Palladium(II) Complexes”
Tetrahedron Lett. 2004, 45 (1), 183-185.
57. Kohsuke Aikawa, Koichi Mikami
“Atropos but Achiral Tris(phosphanyl)biphenyl Ligands for Ru-Catalyzed Asymmetric
Hydrogenation”
Angew. Chem. Int. Ed. 2003, 42 (44), 5455-5258.
58. Kohsuke Aikawa, Koichi Mikami
“Helical Chirality Control of Palladium Complexes That Bear a Tetrakis(phosphanyl)-
terphenyl Ligand: Application as Asymmetric Lewis Acid Catalysts”
Angew. Chem. Int. Ed. 2003, 42 (44), 5458-5461.
59. Koichi Mikami, Yukinori Yusa, Kohsuke Aikawa, Manabu Hatano
“Molecular design of DABNTf as a highly efficient resolving reagent for racemic Pd
complex with tropos biphenylphosphine (BIPHEP) ligand: circular dichroism (CD) spectra
of enantiopure BIPHEP-Pd complex”
Chirality 2003, 15 (1), 105-107.
60. (Review)
Koichi Mikami, Kohsuke Aikawa, Yukinori Yusa, Jonathan J. Jodry, Masahiro Yamanaka
“Tropos or Atropos ? That is the Question !”
Synlett 2002, (10), 1561-1578.
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61. Koichi Mikami, Kohsuke Aikawa
“Dynamic Asymmetric Catalysis by Diphenylphosphinoferrocene (DPPF)-Nickel Complexes
through Control of Axial Chirality by Chiral Diamines”
Org. Lett. 2002, 4 (1), 99-101.
62. Koichi Mikami, Kohsuke Aikawa, Yukinori Yusa
“Asymmetric Activation of the Pd Catalyst Bearing the Tropos Biphenylphosphine (BIPHEP)
Ligand with the Chiral Diaminobinaphthyl (DABN) Activator”
Org. Lett. 2002, 4 (1), 95-97.
63. Koichi Mikami, Kohsuke Aikawa, Yukinori Yusa, Manabu Hatano
“Resolution of Pd Catalyst with tropos Biphenylphosphine (BIPHEP) Ligand by DM-DABN:
Asymmetric Catalysis by an Enantiopure BIPHEP-Pd Complex”
Org. Lett. 2002, 4 (1), 91-94.
64. Toshinobu Korenaga, Kohsuke Aikawa, Masahiro Terada, Susumu Kawauchi, Koichi
Mikami
“Dynamic Chirality Control of (Xyl-)BIPHEP Ligands Leading to their Diastereo- merically
Pure Ru Complexes with a Chiral N-Substituted DPEN”
Adv. Synth. Catal. 2001, 343 (3), 284-288.
65. Koichi Mikami, Kohsuke Aikawa, Toshinobu Korenaga
“General Synthetic Route to Chiral Flexible Biphenylphosphine Ligands: The use of a Chiral
Additive Enables the Preparation and Observation of Metal Complexes Incorporating the
Enantiopure Form”
Org. Lett. 2001, 3 (2), 243-245.
66. Jian Hao, Sonia Taktak, Kohsuke Aikawa, Yukinori Yusa, Manabu Hatano, Koichi Mikami
“Biphenylphosphine-Palladium(II) Complexes-Catalyzed Friedel-Crafts Reaction for the
Synthesis of -Amino and -Hydroxy Indolylacetates and Diindolylacetates”
Synlett 2001, (9), 1443-1444. DOI: 10.1055/s-2001-16802
67. Jun Mihara, Kohsuke Aikawa, Tatsuya Uchida, Ryo Irie, Tsutomu Katsuki
“Lewis acid catalysis of second-generation metallosalen complexes: an explanation for
stereochemistry of asymmetric hetero Diels-Alder reaction”
Heterocycles 2001, 54 (1), 395-404.
68. Kohsuke Aikawa, Ryo Irie, Tsutomu Katsuki
“Asymmetric hetero Diels-Alder reaction using chiral cationic metallosalen complexes as
catalysts”
Tetrahedron 2001, 57 (5), 845-851.
10
著書
1. 相川光介,三上幸一
“フルオロアルキルアルコール”
有機合成化学協会誌“十字路”2016, 74 (3), 271.
2. 相川光介,三上幸一
“ジカチオン性パラジウム錯体を用いたフルオロアルキル化合物の触媒的不斉合成”
有機合成化学協会誌, 2016, , 74 (3), 219-232.
3. 相川光介
“ハロゲン結合を利用した試薬開発:有機フッ素化学における新反応開発の迅速化” 化学 注目論文の欄 2015, Vol.70, No. 12, pp 64-65.
4. 相川光介
“含トリフルオロメチル化合物の実用的合成法の開発”
化学と工業 “飛翔する若手科学者”2013, 66 (7), 565-567.
5. 相川光介,三上幸一
“歯車効果(gear or cogwheel effect)”
有機合成化学協会誌“十字路”2012, 70 (12), 71.
6. 相川光介,三上幸一
“動的キラルな配位子を活用した不斉触媒反応の開発”
有機合成化学協会誌, 2012, 70 (12), 45-58.
7. Koichi Mikami, Masahiro Yamanaka, Manabu Hatano, Kohsuke Aikawa
“Asymmetric Catalysis of Ene Reactions”
Organic Reactions; Scott D. Rychnovsky, Ed.; ACS: Washington D.C., in press
8. 三上幸一,小島雅史,相川光介
“Chirality資源としてのラセミ体”
化学工業,2010, 11月号(61巻), 855-860.
9. Koichi Mikami, Kohsuke Aikawa
“Asymmetric Ene-Reactions and Cycloadditions”
Catalytic Asymmetric Synthesis, Third Edition; Ojima, I., Ed.; WILEY: Hoboken, New Jersey,
2010; Chapter 8D, pp 683-737.
10. Koichi Mikami, Kohsuke Aikawa
“Asymmetric Activation and Deactivation of Racemic Catalysts”
New Frontier in Asymmetric Catalsis; Mikami, K., Lautens, M., Eds.; WILEY: Hoboken,
New Jersey, 2007; Chapter 8, pp 221-257.
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特許
(1) 「光学活性含フッ素カルボニル-エン生成物の製造方法」
特許登録第 5090773 号(登録日 2012.9.21)
発明者 三上幸一、相川光介、石井章央、茂木香織、大塚隆史
出願人 国立大学法人東京工業大学、セントラル硝子株式会社
① 特願 2006−350616, 2006.12.26
② 特願 2007−047530, 2007.2.27 (①を基礎とする国内優先権主張出願)
③ 特願 2007−108681, 2007.4.17 (①、②を基礎とする国内優先権主張出願)
特開 2008−239593, 2008.10.9
“Method for producing optically active fluorine-containing carbonyl-ene product”
Koichi Mikami, Kohsuke Aikawa, Akihiro Ishii, Kaori Mogi, Takashi Ootsuka
国際出願番号 PCT/JP2007/74290, 国際出願日 2007.12.18
国際公開番号WO/2008/078601 A1, 国際公開日 2008.7.3
Japanese Patent No. 5090773, Sep 21 (2012)
Pub. No. WO2008078601 A1, Jul 3 (2008)
United States Patent No. US8278479 B2, Oct 2 (2012)
European Patent No. EP2402328 B1, Oct 2 (2013)
Chinese Patent No. ZL200780047082.3, May 29 (2013)
Indian Patent No. 262693, Sep 5 (2014)
(2) 「光学活性芳香族複素5員環置換ヒドロキシ酢酸エステルの製造方法」
特許登録第 5570840 号(登録日 2014.7.4)
発明者 三上幸一、相川光介、日置優太
出願人 国立大学法人東京工業大学、セントラル硝子株式会社
特願 2010-030659, 2010.2.15
特開 2011-162526, 2011.8.25
(3) 「光学活性含フッ素アルキニル化生成物の製造方法」
特許登録第 5303311 号(登録日 2013.6.28)
発明者 三上幸一、相川光介、日置優太
出願人 国立大学法人東京工業大学、セントラル硝子株式会社
特願 2009-044683 (09K01621, 2/26)
特開 2010-195736, 2010.9.9
(4) 「光学活性含フッ素オキセタンの製造方法」
特許登録第 5507285号(登録日 2014.3.28)
発明者 三上幸一、相川光介、会田淳平、石井章夫、加藤美杉、増田隆司
出願人 国立大学法人東京工業大学、セントラル硝子株式会社
① 特願 2009-044684 (09K01622, 2/26)
② 特願 2010-034169, 2010.2.19 (①の国内優先出願)
12
特開 2010−222345, 2010.10.7
“Method for producing optically active fluorinated oxetane”
Koichi Mikami, Kohsuke Aikawa, Junpei Aida, Akihiro Ishii, Misugi Kato, Takashi Masuda
国際出願番号 PCT/JP2010/052638, 国際出願日 2010.2.22
国際公開番号WO/2010/098288 A1, 国際公開日 2010.9.2
Japanese Patent No. 5507285, Mar 28 (2014)
Pub. No. WO2010098288 A1, Sep 2 (2010)
Chinese Patent No. ZL201080009615.0, Jul 22 (2015)
(5) 「光学活性コンボルタミジン誘導体の製造方法」
発明者 三上幸一、相川光介、三村俊介
出願人 国立大学法人東京工業大学、セントラル硝子株式会社
特願 2009-044685 (09K01623, 2/26)
特開 2010-195737, 2010.9.9
(6) 「不斉カルボニル-エン反応による光学活性コンボルタミジン誘導体の製造方法」
発明者 三上幸一、相川光介、三村俊介
出願人 国立大学法人東京工業大学、セントラル硝子株式会社
特願 2009-055361 (09K01633, 3/9)
特開 2010-208975, 2010.9.24
(7) 「BIPHEP誘導体を配位子とする光学活性遷移金属錯体」
特許登録第 5501636号(登録日 2014.3.20)
発明者 三上幸一、相川光介、宮崎仁孝
出願人 国立大学法人東京工業大学、セントラル硝子株式会社
特願 2009-058064 (09K01635, 3/11)
特開 2010-209013, 2010.9.24
(8) 「光学活性含フッ素オキセテンの製造方法」
特許登録第 5669534号(登録日 2014.12.26)
発明者 三上幸一、相川光介、日置優太
出願人 国立大学法人東京工業大学、セントラル硝子株式会社
特願 2010-263128, 2010.11.26
特開 2012-111721, 2012. 6.14
“Method for producing optically active fluorine-containing oxetene”
Koichi Mikami, Kohsuke Aikawa, Yūta Hioki
国際出願番号 PCT/JP2011/076359, 国際出願日 2011.11.16
国際公開番号 WO/2012/070437 A1, 国際公開日 2012.5.31
13
Japanese Patent No. 5669534, Dec 26 (2014)
Pub. No. WO2012070437 A1, May 31 (2012)
Chinese Patent No. ZL201180056741.6, Jul 29 (2015)
United States Patent No. US8859789 B2, Oct 14 (2014)
European Patent No. EP2644605 B1, Apr 6 (2016)
(9) 「トリフルオロメチル化剤、その製造方法並びにそれを用いたトリフルオロメチル
基含有化合物の製造方法」
特許登録第 5941338号(登録日 2016.5.27)
発明者 三上幸一、中村雄三、相川光介
出願人 国立大学法人東京工業大学、東ソー・エフテック株式会社
特願 2012-113898, 2012.5.18
特開 2013-241345, 2013.12.5
(10) 「トリフルオロメチル化剤粉末、その製造方法並びにそれを用いたトリフルオロメ
チル基含有化合物の製造方法」
特許登録第 5889817号(登録日 2016.2.26)
発明者 三上幸一、中村雄三、根岸千幸、相川光介
出願人 国立大学法人東京工業大学、東ソー・エフテック株式会社
特願 2013-032699, 2013.2.22
特開 2014-162732, 2014.9.8
(11) 「トリフルオロメチル銅の製造方法」
発明者 三上幸一、芹澤宏希、張媛、根岸千幸、相川光介
出願人 国立大学法人東京工業大学、セントラル硝子株式会社
特願 2013-044939, 2013.3.7
特開 2014-172831, 2014.9.22
(12) 「ビス(トリフルオロメチル)亜鉛・DMPU錯体、その製造方法並びにそれを用
いたトリフルオロメチル基含有化合物の製造方法」
発明者 三上幸一、中村雄三、根岸千幸、相川光介
出願人 国立大学法人東京工業大学、東ソー・エフテック株式会社
特願 2013-180007, 2013.8.30
特開 2015-048322, 2015.3.16
(13) 「ジフルオロシクロプロパン化合物類の製造方法」
発明者 三上幸一、中村雄三、根岸千幸、相川光介
出願人 国立大学法人東京工業大学、東ソー・エフテック株式会社
特願 2013-199096, 2013.9.26
特開 2015-063491, 2015.4.9
14
(14) 「ジフルオロメチル亜鉛化合物」
発明者 三上幸一、石井洸毅、相川光介
出願人 国立大学法人東京工業大学、東ソー・エフテック株式会社
特願 2015-059500, 2015.3.23
受賞歴
2007年 有機合成化学協会 研究企画賞「味の素」
2008年 東工大工系若手奨励賞
2010年 東工大挑戦的研究賞
2012年 文部科学大臣表彰 若手科学者賞
2012年 みずほ学術振興財団第 55回工学研究助成
2013年 日本化学会 第 27回若い世代の特別講演会表彰
2014年 野口研究所 野口遵研究助成金
2015年 有機合成化学奨励賞